Journal articles: 'Plant cytotoxicity'

1

Brown, Eric G., and Muhsin Konuk. "Plant cytotoxicity of nebularine (purine riboside)." Phytochemistry 37, no. 6 (December 1994): 1589–92. http://dx.doi.org/10.1016/s0031-9422(00)89572-2.

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Capua, Christopher J., Nick P. Hopson, C. Malcolm M. Stewart, G. Robert Johnston, Kim L. O'Neill, G. Bruce Schaalje, Christopher M. Lee, and Gary M. Booth. "Cytotoxicity ofAtriplex confertifolia." Journal of Toxicology 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/976548.

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The search for cancer treatment continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, mostly from tropically located plants. This study reports that extracts ofAtriplex confertifolia(Torr. and Frem.) S. Watson (Chenopodiaceae), a native North American plant (also known as shadscale or saltbush), has significant bioactivity against human breast cancer cell lines MCF-7, MDA-MB 435, MDA-MB 231, and HeLa cells (cervical cancer cells). The bioactivity ofA. confertifoliaextracts on these cells lines was compared to an FDA-approved cancer drug (Onxol®) and an industry-standard leukocyte control cell line. Active portions of the extracts were found primarily in the polar fractions of the plant. A dose-response curve of the extracts displayed significant cell death similar to Onxol®. The plant extracts did not significantly inhibit the viability of the leukocyte cell line. In a timed study, over 90% of cell lines MDA-MB 435 and HeLa died after 24 hours. Cell death appears to result from apoptosis.

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Debnath, Subal, SanthoshC Kumar, AtulN Chandu, and Chiranjib Bhattacharjee. "Cytotoxicity study of plant Aloe vera (Linn)." Chronicles of Young Scientists 3, no. 3 (2012): 233. http://dx.doi.org/10.4103/2229-5186.99595.

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Mori, Akihisa, Chikao Nishino, Nobuyasu Enoki, and Shinkichi Tawata. "Cytotoxicity of plant flavonoids against HeLa cells." Phytochemistry 27, no. 4 (1988): 1017–20. http://dx.doi.org/10.1016/0031-9422(88)80264-4.

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Matoušek, Jaroslav, Tomás Podzimek, Pavla Poučková, Jan Stehlík, Jiří Škvor, Josef Souček, and Josef Matoušek. "Antitumor Effects and Cytotoxicity of Recombinant Plant Nucleases." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 18, no. 4 (April 1, 2009): 163–71. http://dx.doi.org/10.3727/096504009790217425.

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Cornara, Laura, Gian Luigi Mariottini, Paolo Giordani, Antonella Smeriglio, Domenico Trombetta, Lucrezia Guida, Silvia Lavorano, and Bruno Burlando. "Modulatory Activities of Plant Extracts on Jellyfish Cytotoxicity." Wilderness & Environmental Medicine 31, no. 3 (September 2020): 266–72. http://dx.doi.org/10.1016/j.wem.2020.03.004.

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Volpato, Luiz Evaristo Ricci, Paula Gabrielle de Castro Trigueiro, Andreza Maria Fabio Aranha, Ivana Maria Povoa Violante, Rafaela Alves da Silva, and Rodrigo Cardoso de Oliveira. "Antimicrobial potential of plant extracts from the Brazilian Cerrado." Brazilian Dental Journal 33, no. 1 (February 2022): 96–104. http://dx.doi.org/10.1590/0103-6440202204705.

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Abstract Bacteria are related do different oral diseases, such as dental caries and periodontal disease. Therefore, the control or/and eradication of microorganisms and their by-products is primordial for the success of their treatment. An alternative for decrease bacterial load is the use of plant extracts used in popular medicine. The cytotoxicity and antimicrobial action of extracts of Cariniana rubra Gardiner ex Miers, Senna martiniana, Anadenanthera colubrina (Vell.) Brenan and Spiranthera odoratissima St. Hil. against strains of Streptococcus mutans, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Aggregatibacter actinomyces- tencomitans and Candida albicans were investigated. Cytotoxicity was assessed at concentrations of 1, 10, 40, 80, 100 and 1000 μg/mL by means of the MTT test and compared to a control group with untreated cells. Those with acceptable cytotoxicity had the antimicrobial action measured by the XTT test. As a positive control, sodium hypochlorite was used. Cariniana rubra Gardiner ex Miers had the highest citototoxicity results while Spiranthera odoratissima St. Hil. had the best results, but all extracts showed acceptable cytotoxicity at different concentrations. The plant extracts showed higher activity against A. actinomycetencomitans: Anadenanthera columbrina (Vell.) Brenan (80.52%) at 40 μg/mL, Spiranthera odoratissima St. Hil (78.48%) in 1 μg/mL, Senna martiniana (73.28%) in the concentration of 40 μg/mL and Cariniana rubra Gardiner ex Miers (70.50%) in 10 μg/mL. All extracts analyzed showed acceptable cytotoxicity at different concentrations and were promising for inhibition of the pathogenic microorganisms studied.

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Chon, Heeson, Gyeomheon Kim, and Sungkwon Kim. "Comparison of Aqueous Plant Extracts before and after Fermentation with Lactobacillus Paracasei LS-2 on Cytokine Induction and Antioxidant Activity." Natural Product Communications 5, no. 8 (August 2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500827.

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This study was conducted to investigate the antioxidant properties and inhibitory effects on the inflammation-related cytokines of plant extracts fermented with Lactobacillus paracasei LS-2 in comparison with the unfermented aqueous plant extract. Attempted have also been made to identify fermented plant extracts that display no cytotoxicity against murine macrophage cells, while still maintaining their biological characteristics. Most of the fermented plant extracts showed reduced cytotoxicity. Among the fourteen plant extracts tested, the fermented plant extract of Scutellaria baicalensis Georgi increased the induction of antiinflammatory mediators; however, they were still cytotoxic. Interestingly, the plant extract of Artemisia capillaris Thunb. induced a dramatic increase in the induction of antiinflammatory mediators with no cytotoxicity through fermentation. Our findings suggest that fermented A. capillaris holds promise for use as a valuable natural non-cytotoxic antioxidant and immuno-modulating agent.

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Uddin, Shaikh J., I. Darren Grice, and Evelin Tiralongo. "Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–7. http://dx.doi.org/10.1093/ecam/nep111.

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To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted withn-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer-cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculataandHibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC501.1–1.6 mg mL−1). Seven methanolic extracts fromL. indica,Clerodendron inerme,Cynometra ramiflora,Xylocarpus moluccensis,Argemone mexicana,Ammannia bacciferaandAcrostichum aureumand four aqueous extracts fromHygrophila auriculata,Bruguiera gymnorrhiza,X. moluccensisandAegiceras corniculatumshowed low toxicity (IC50> 2.5 mg mL−1) against mouse fibroblasts but selective cytotoxicity (IC500.2–2.3 mg mL−1) against different cancer cell lines. The methanolic extract ofBlumea lacerashowed the highest cytotoxicity (IC500.01–0.08 mg mL−1) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.

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Al-Mezaine, Hani S., Mohammed A. Al-Amry, Abdullah Al-Assiri, Talal S. Fadel, Khalid F. Tabbara, and Ali A. Al-Rajhi. "Corneal Endothelial Cytotoxicity of the Calotropis procera (Ushaar) Plant." Cornea 27, no. 4 (May 2008): 504–6. http://dx.doi.org/10.1097/ico.0b013e3181611c34.

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Spiridonov, Nikolay A., Dmitrii A. Konovalov, and Vladimir V. Arkhipov. "Cytotoxicity of some Russian ethnomedicinal plants and plant compounds." Phytotherapy Research 19, no. 5 (2005): 428–32. http://dx.doi.org/10.1002/ptr.1616.

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Smirnova, I. E., A. V. Petrova, and O. B. Kazakova. "Synthesis and Cytotoxicity of A-Azepanodammaradiene." Chemistry of Natural Compounds 55, no. 5 (September 2019): 883–89. http://dx.doi.org/10.1007/s10600-019-02838-w.

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Nadaraia, N. Sh, N. N. Barbakadze, V. D. Mshvildadze, B. Sylla, J. Legault, and A. Pichette. "Synthesis and Cytotoxicity of Epiandrosterone Hydrazones." Chemistry of Natural Compounds 56, no. 2 (March 2020): 274–77. http://dx.doi.org/10.1007/s10600-020-03005-2.

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14

Li, Ruxin, Shubin Niu, Liangdong Guo, and Yang Zhang. "Two New Pyrone Derivatives from the Plant Endophytic Fungus Exserohilum sp." Natural Product Communications 9, no. 10 (October 2014): 1934578X1400901. http://dx.doi.org/10.1177/1934578x1400901023.

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Two new α-pyrones, Exserolide G–H (1–2), together with one known metabolite, stemphypyrone (3), were isolated from the solid-substrate fermentation cultures of the plant endophytic fungus Exserohilum sp. The structures of the new compounds were elucidated primarily by analysis of NMR data. Compounds 1–3 were tested for cytotoxicity against a small panel of human carcinoma cell lines. Compound 1 showed cytotoxicity against HeLa, A549 and HCT116 cells.

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Booth, Gary M., Robert D. Malmstrom, Erica Kipp, and Alexandra Paul. "Cytotoxicity of Selected Medicinal and Nonmedicinal Plant Extracts to Microbial and Cervical Cancer Cells." Journal of Biomedicine and Biotechnology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/106746.

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This study investigated the cytotoxicity of 55 species of plants. Each plant was rated as medicinal, or nonmedicinal based on the existing literature. About 79% of the medicinal plants showed some cytotoxicity, while 75% of the nonmedicinal plants showed bioactivity. It appears that Asteraceae, Labiatae, Pinaceae, and Chenopodiaceae were particularly active against human cervical cancer cells. Based on the literature, only three of the 55 plants have been significantly investigated for cytotoxicity. It is clear that there is much toxicological work yet to be done with both medicinal and nonmedicinal plants.

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Tagge, E., J. Chandler, B. L. Tang, W. Hong, M. C. Willingham, and A. Frankel. "Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi." Journal of Histochemistry & Cytochemistry 44, no. 2 (February 1996): 159–65. http://dx.doi.org/10.1177/44.2.8609372.

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DNAs encoding ricin toxin A chain (RTA), with or without a C-terminal endoplasmic reticulum retention signal KDEL, were subcloned into pGEX2T bacterial expression plasmid. After transformation of JM105 E. coli cells and induction with isopropylthio-beta-galactoside (IPTG), fusion proteins were bound to an immobilized glutathione matrix and recombinant ricin A chains released with thrombin. Both recombinant wild-type RTA and RTA with KDEL had immunological reactivity and catalytic activity indistinguishable from plant RTA. The bacterial RTA products reassociated with plant ricin B chain (RTB) similarly to plant RTA. Cell cytotoxicities were measured on seven cell lines for each A-chain and heterodimer. Although KDEL sequences enhanced cytotoxicity in most cases, significant variability was observed. In each case, addition of KDEL enhanced A-chain cytotoxicity more than holotoxin cytotoxicity. Three cell lines showed reduced KDEL enhancement of both RTA and ricin cytotoxicity. The concentration of KDEL receptor was examined on each cell line by immunofluorescence microscopy with an antireceptor monoclonal antibody. Differences in sensitivity to KDEL-containing toxins correlated with altered distribution of KDEL receptor between endoplasmic reticulum (ER) and Golgi compartments.

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Haghighat, Mojtaba, Hajar Q. Alijani, Masoomeh Ghasemi, Sajad Khosravi, Fariba Borhani, Fatemeh Sharifi, Siavash Iravani, Kazem Najafi, and Mehrdad Khatami. "Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures." Bioprocess and Biosystems Engineering 45, no. 1 (September 28, 2021): 97–105. http://dx.doi.org/10.1007/s00449-021-02643-2.

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Najmus-Saqib, Qazi, Fiaz Alam, and Mansoor Ahmad. "Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla." Journal of Enzyme Inhibition and Medicinal Chemistry 24, no. 3 (October 20, 2008): 697–701. http://dx.doi.org/10.1080/14756360802333406.

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Adler-Flindt, Sarah, and Sabine Martin. "Comparative cytotoxicity of plant protection products and their active ingredients." Toxicology in Vitro 54 (February 2019): 354–66. http://dx.doi.org/10.1016/j.tiv.2018.10.020.

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Kluza, Jérôme, Brigitte Baldeyrou, Pierre Colson, Philippe Rasoanaivo, Lengo Mambu, François Frappier, and Christian Bailly. "Cytotoxicity and DNA binding properties of the plant alkaloid burasaine." European Journal of Pharmaceutical Sciences 20, no. 4-5 (December 2003): 383–91. http://dx.doi.org/10.1016/j.ejps.2003.08.007.

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Kuete, Victor, Benjamin Krusche, Mahmoud Youns, Igor Voukeng, Aimé G. Fankam, Simplice Tankeo, Stephen Lacmata, and Thomas Efferth. "Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts." Journal of Ethnopharmacology 134, no. 3 (April 2011): 803–12. http://dx.doi.org/10.1016/j.jep.2011.01.035.

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Gurunathan, Sangiliyandi. "Cytotoxicity of graphene oxide nanoparticles on plant growth promoting rhizobacteria." Journal of Industrial and Engineering Chemistry 32 (December 2015): 282–91. http://dx.doi.org/10.1016/j.jiec.2015.08.027.

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Nguyen, Sinh Truong, Le Van Manh Hung, Nguyen Thi Thanh Mai, Nguyen Trung Nhan, Nguyen Xuan Hai, Ngoc Kim Phan, Kiet Truong Dinh, and Phuc Van Pham. "In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells." Biomedical Research and Therapy 6, no. 8 (August 20, 2019): 3325–32. http://dx.doi.org/10.15419/bmrat.v6i8.559.

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Objective: Cancer has been considered as one of the world's leading causes of death. Recently, the Paramignya trimera plant, locally called ``Xao Tam Phan'', has become a popular Vietnamese medicinal herb that is used as alternative medicine for cancer treatment support with minimal side effects. In this study, we aimed to demonstrate the cytotoxicity of methanolic extract of Paramignya trimera on a Vietnamese breast cancer stem cell line (VNBRCA1) in vitro. Methods: We used the MTT assay to determine the cytotoxicity of the extract on VNBRCA1 cells and human fibroblast (HF) cell line was used as a control for the plant extract treatment. Clinically used anticancer drug, doxorubicin, was used as a control drug (for relative comparison to the plant extract) to evaluate the selective cytotoxicity of the plant extract on VNBRCA1 and HF cells. We examined the apoptosis induction by the plant extract on VNBRCA1by Annexin V/7AAD staining and flow cytometry analysis. In addition, the morphology of apoptotic nuclei of treated cells was observed by fluorescent microscopy using double fluorescent staining: Hoechst 33342 and propidium iodide (PI). Results: In comparison between the cytotoxicity of the plant extract and Doxorubicin on both cell lines (VBRCA1 and HF), we observed that plant extract was selectively cytotoxic against VNBRCA1 with an IC50 value of 10610 μg/mL, while Doxorubicin was discriminatorily cytotoxic against HF with an IC50 value of 0.135+/-0.09 μg/mL. We also found that the plant extract induced apoptosis VNBRCA1 in a dose-dependent manner. In addition, fluorescent microscopy revealed disintegrated nuclei of plant extract-treated cells, representing a hallmark of apoptosis. Conclusions: These results showed that Paramignya trimera methanolic extract selectively killed VNBRCA1 cell lines, indicating that Paramignya trimera methanolic extract may represent a potential agent for cancer treatment.

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Banfalvi, Gaspar. "Janus-Faced Molecules against Plant Pathogenic Fungi." International Journal of Molecular Sciences 22, no. 22 (November 15, 2021): 12323. http://dx.doi.org/10.3390/ijms222212323.

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The high cytotoxicity of the secondary metabolites of mycotoxins is capable of killing microbes and tumour cells alike, similarly to the genotoxic effect characteristic of Janus-faced molecules. The “double-edged sword” effect of several cytotoxins is known, and these agents have, therefore, been utilized only reluctantly against fungal infections. In this review, consideration was given to (a) toxins that could be used against plant and human pathogens, (b) animal models that measure the effect of antifungal agents, (c) known antifungal agents that have been described and efficiently prevent the growth of fungal cells, and (d) the chemical interactions that are characteristic of antifungal agents. The utilization of apoptotic effects against tumour growth by agents that, at the same time, induce mutations may raise ethical issues. Nevertheless, it deserves consideration despite the mutagenic impact of Janus-faced molecules for those patients who suffer from plant pathogenic fungal infections and are older than their fertility age, in the same way that the short-term cytotoxicity of cancer treatment is favoured over the long-term mutagenic effect.

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Figueiró, Luciana Rizzieri, Luana Christine Comerlato, Marcia Vignoli Da Silva, José Ângelo Silveira Zuanazzi, Gilsane Lino Von Poser, and Ana Luiza Ziulkoski. "Original Article. Toxicity of Glandularia selloi (Spreng.) Tronc. leave extract by MTT and neutral red assays: influence of the test medium procedure." Interdisciplinary Toxicology 9, no. 1 (March 1, 2016): 25–29. http://dx.doi.org/10.1515/intox-2016-0004.

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Abstract Cytotoxicity assays using cell cultures may be an alternative to assess biological toxicity of plant extracts with potential phytotherapeutic properties. This study compared three methods to prepare culture media for the exposure of Vero cells to plant extracts. Leaves of Glandularia selloi (Spreng.) Tronc. were used to prepare culture medium with aqueous extract, extract in culture medium and methanol extract. Toxicity was assessed using the MTT and neutral red (NR) assays. In general, alterations in the cellular functions were found in all extracts and assays. Cytotoxic effect occurred at lower doses in aqueous extract and the range of effect of the methanol extract was small. The procedure of preparing the test medium has an effect on the outcome of the assay. Cytotoxicity of plant extract can be assessed by MTT and NR assays. Aqueous extract added to the culture medium presented the best profile to assess cytotoxicity.

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Hägg, Maria, Maria Berndtsson, Aleksandra Mandic, Rong Zhou, Maria C. Shoshan, and Stig Linder. "Induction of endoplasmic reticulum stress by ellipticine plant alkaloids." Molecular Cancer Therapeutics 3, no. 4 (April 1, 2004): 489–97. http://dx.doi.org/10.1158/1535-7163.489.3.4.

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Abstract Anticancer drugs often show complex mechanisms of action, including effects on multiple cellular targets. Detailed understanding of these intricate effects is important for the understanding of cytotoxicity. In this study, we examined apoptosis induction by ellipticines, a class of cytotoxic plant alkaloids known to inhibit topoisomerase II. The potent ellipticine derivative 6-propanamine ellipticine (6-PA-ELL) induced rapid apoptosis in MDA-MB-231 breast cancer cells, preceded by a conformational change in Bak and cytochrome c release. Experiments using knock-out mouse embryo fibroblasts established that Bak was of particular importance for cytotoxicity. 6-PA-ELL increased the expression of the endoplasmic reticulum chaperones GRP78/BiP and GRP94, suggesting induction of endoplasmic reticulum stress. Induction of GRP78 expression was dependent on the endoplasmic reticulum stress response element (ERSE) of the GRP78 promoter. Examination of different ellipticine derivatives revealed a correlation between pro-apoptotic activity and the ability to induce GRP78 expression. Furthermore, 6-PA-ELL was found to induce splicing of the mRNA encoding the XBP1 transcription factor, characteristic of endoplasmic reticulum stress, and to induce activation of the endoplasmic reticulum-specific caspase-12 in mouse colon cancer cells. We finally demonstrate that 6-PA-ELL induces apoptotic signaling also in enucleated cells, consistent with the existence of a cytoplasmic target for this compound. Our data suggest that induction of endoplasmic reticulum stress may contribute to the cytotoxicity of ellipticines.

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Rahman, Mohammad S., Bilkis Begum, Rasheduzzaman Chowdhury, Khondaker M. Rahman, and Mohammad A. Rashid. "Preliminary Cytotoxicity Screening of Some Medicinal Plants of Bangladesh." Dhaka University Journal of Pharmaceutical Sciences 7, no. 1 (October 7, 2008): 47–52. http://dx.doi.org/10.3329/dujps.v7i1.1217.

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The cytotoxic activity of the methanolic extracts of 35 plant species, including 28 traditionally used plants of Bangladesh was evaluated by the brine shrimp lethality bioassay technique. Among these, 19 plant extracts exhibited significant toxicity to brine shrimps with LC50 less than 10 Î¼g/ml.Key words: Cytotoxic activity, Brine shrimp lethality bioassay.DOI = 10.3329/dujps.v7i1.1217Dhaka Univ. J. Pharm. Sci. 7(1): 47-52, 2008 (June)

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Saroyo, Haryoto, and Nur Fajariyah Maulidah Saputri. "Cytotoxicity of Mangrove Leaves (Rhizophora) Ethanolic Extract on Cancer Cells." Journal of Nutraceuticals and Herbal Medicine 4, no. 1 (November 25, 2021): 43–52. http://dx.doi.org/10.23917/jnhm.v4i1.15657.

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Cancer is a disease that can attack any part of the body when the abnormal cells begin to grow uncontrollably beyond the limit, then attack the connected parts of the body and spread to other organs. The mangrove (Rhizophora) is a herbal plant that can be used as a treatment for various diseases, one of which is cancer. The mangrove (Rhizophora) plant contains phytochemicals ranging from fruit, seeds, leaves and roots. This review article aims to examine the cytotoxicity effects of mangrove (Rhizophora) plants on cancer cells. The library sources in this article review use the Google Scholar and PubMed databases. The inclusion criteria used were articles containing the cytotoxic test of mangrove (Rhizophora) with the last 10 years of publication (2011-2020), original research, there were results of anticancer activity in the form of IC50 and research using mangrove (Rhizophora). plant extracts. The exclusion criteria used were articles that did not contain a full text, used plants with different genus, did not have an IC50 value and were not original research. From the journals that have been analyzed, it can be said that the extract of the mangrove (Rhizophora) plant can be developed for cancer treatment. The mangrove (Rhizophora) plant has cytotoxic activity because it contains active compounds in the form of phenolic, flavonoids and terpenoids. Based on the results of the cytotoxic test of mangrove (Rhizophora) extract, the plant parts that have the strongest cytotoxic effect are fruit.

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Pukhov, S. A., S. V. Afanas’eva, L. V. Anikina, V. I. Kozlovskii, M. E. Neganova, and S. G. Klochkov. "Cytotoxicity of Natural Alantolactones Conjugated to Substituted Piperazines." Chemistry of Natural Compounds 55, no. 1 (January 2019): 41–46. http://dx.doi.org/10.1007/s10600-019-02611-z.

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Zeng, Ting, Jin Liu, Ming-rong Yang, Tai Yang, and Li-mei Li. "Chemical Constituents of Amalocalyx yunnanesis and Their Cytotoxicity." Chemistry of Natural Compounds 56, no. 1 (January 2020): 127–29. http://dx.doi.org/10.1007/s10600-020-02961-z.

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Khusnutdinova, E. F., I. E. Smirnova, and O. B. Kazakova. "Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives." Chemistry of Natural Compounds 56, no. 3 (May 2020): 465–71. http://dx.doi.org/10.1007/s10600-020-03064-5.

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Zahirnia, Amirhossein, Mitra Boroomand, Hassan Nasirian, Aref Salehzadeh, and Sara Soleimani-Asl. "Comparing cytotoxicity of propoxur and Nepeta crispa (Lamiales: Lamiaceae) essential oil against invertebrate (Sf9) and vertebrate (L929) cell lines." November-2019 12, no. 11 (November 2019): 1698–706. http://dx.doi.org/10.14202/vetworld.2019.1698-1706.

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Background and Aim: Attempts to use the plant products are to be an appropriate option due to substantial concerns about human health and environmental problems of using synthetic pesticides. Therefore, the cytotoxicity of Nepeta crispa essential oil was compared with propoxur against invertebrate (Sf9) and vertebrate (L929) cell lines. Materials and Methods: The cell lines of Sf9 and L929 which were derived from the ovary glands of fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) and mouse fibroblast cells, respectively, were obtained from the National Cell Bank of Pasteur Institute of Iran. About a number of 2 × 103 cells were placed into the wells of 96-well plate experiments. Then, appropriate concentrations of essential oil of N. crispa plant and propoxur added to the wells. The cells were allowed to grow for 3-5 days and estimated the numbers of cells. The cells of control experiment wells contained only cells with dimethyl sulfoxide. All control and treatment experiments repeated at least four replicates. Results: Propoxur had negative effects on the viability of both invertebrate (Sf9) and vertebrate (L929) cell lines. The cytotoxicity of propoxur against invertebrate (Sf9) and vertebrate (L929) cell lines was gradually increased in accordance with propoxur concentrations. The cytotoxicity of N. crispa essential oil against vertebrate (L929) cell line was gradually decreased in accordance with plant concentrations, while the cytotoxicity of N. crispa essential oil against invertebrate (Sf9) cell line was strongly increased in accordance with plant concentrations. Conclusion: Plant essential oil not only had no negative effects but also had boosting effects on vertebrate cell viability. Essential oil of N. crispa plant had negative effects on invertebrate cell viability with the differences that the products derived from plants possessing of biodegradable and environmentally friendly derivatives, hydrolyzing rapidly in nature, and nearly having no destructive effects on environment, humans, or the mammals.

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Fouda, Farhat. "Cytotoxicity Assessments of Portulaca Oleracea Plant Extracts on Some Cancer Cells." Annals of Agricultural Science, Moshtohor 60, no. 3 (September 1, 2022): 835–44. http://dx.doi.org/10.21608/assjm.2022.263828.

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Hanan, Nurul, Hock Chiu, Muggundha Ramachandran, Wai Tung, Nur Mohamad Zain, Noorfatimah Yahaya, and Vuanghao Lim. "Cytotoxicity of Plant-Mediated Synthesis of Metallic Nanoparticles: A Systematic Review." International Journal of Molecular Sciences 19, no. 6 (June 11, 2018): 1725. http://dx.doi.org/10.3390/ijms19061725.

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El-Din, Mariam. "Cytotoxicity of Enterolobium timbouva Plant Extract and Its Isolated Pure Compounds." British Journal of Pharmaceutical Research 4, no. 7 (January 10, 2014): 826–36. http://dx.doi.org/10.9734/bjpr/2014/5020.

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Lindholm, Petra, Joachim Gullbo, Per Claeson, Ulf Goransson, Senia Johansson, Anders Backlund, Rolf Larsson, and Lars Bohlin. "Selective Cytotoxicity Evaluation in Anticancer Drug Screening of Fractionated Plant Extracts." Journal of Biomolecular Screening 7, no. 4 (August 2002): 333–40. http://dx.doi.org/10.1177/108705710200700405.

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Chosen to reflect biodiversity in a phylogenetic sense, 100 fractionated plant extracts were screened in vitro for cytotoxicity following extraction and fractionation (polypeptide isolation). Of these 100 extracts, 30 were selected and then characterized preliminarily for antitumor potency and mode of action by testing them on two cell lines and primary cultures of human tumor cells. On the basis of cytotoxicity potency, 10 of the extracts were further characterized for anticancer activity in 10 human tumor cell lines. This final testing resulted in seven potential lead plants with superior evidence of antitumor potential: Colchicum autumnale L. (Colchicaceae), Digitalis lanata Ehrh. and Digitalis purpurea L. (Plantaginaceae), Helleborus cyclophyllus Boiss. (Ranunculaceae), Menyanthes trifoliata L. (Menyanthaceae), and Viola arvensis Murr. and Viola patrinii Ging. (Violaceae). Within a database of antitumor compounds, the activity profiles of the extracts from these seven plants were compared, by correlation analysis, with those of more than 100 other compounds, including 39 standard drugs from different classes of cytotoxic mechanisms. The activity profiles of six of these candidates were uncorrelated with those of the standard drugs, possibly indicating new pathways of drug-mediated cell death.

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Riaz, Muhammad, Nasir Rasool, Shahid Rasool, Umer Rashid, Iftikhar Hussain Bukhari, Muhammad Zubair, Mnaza Noreen, and Mazhar Abbas. "Chemical Analysis, Cytotoxicity and Antimicrobial Studies by Snapdragon: A Medicinal Plant." Asian Journal of Chemistry 25, no. 10 (2013): 5479–82. http://dx.doi.org/10.14233/ajchem.2013.14854.

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THABREW, M. IRA, ROBIN D. HUGHES, and IAN G. MCFARLANE. "Screening of Hepatoprotective Plant Components using a HepG2 Cell Cytotoxicity Assay." Journal of Pharmacy and Pharmacology 49, no. 11 (November 1997): 1132–35. http://dx.doi.org/10.1111/j.2042-7158.1997.tb06055.x.

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Kamuhabwa, Appolinary, Charles Nshimo, and Peter de Witte. "Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine." Journal of Ethnopharmacology 70, no. 2 (May 2000): 143–49. http://dx.doi.org/10.1016/s0378-8741(99)00161-0.

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Seifert, Georg, Holger N. Lode, Stephan Lobitz, Karl Seeger, Alfred Laengler, and Guenter Henze. "Enhancement of Lymphokine-Activated Killer Cell Cytotoxicity by Mistletoe Plant Extracts." Blood 106, no. 11 (November 16, 2005): 3919. http://dx.doi.org/10.1182/blood.v106.11.3919.3919.

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Abstract Anthroposophical cancer therapies focus on the use of mistletoe (MT) preparations and extracts from European mistletoe (Viscum album l.) belong to the complementary therapeutic regimens. Although widely used in Europe as an additional therapy in the treatment of patients suffering from different malignancies, these cancer therapies have remained relatively unknown in North America. To date, mistletoe is the most commonly used complementary cancer drug in Germany, applied as monotherapy or in combination with conventional therapies. ABNOBAviscum fraxini is a standardized extract from all parts of fresh mistle, obtained from the ash tree. This study aims to investigate the effects of MT on the activity of lymphokine-activated killer (LAK) cell cytotoxicity in vivo. Here, we demonstrate that in vivo treatment of mice with a standardized MT plant extract results in activation and function of LAK cells. We show an enhanced cytotoxicity against the NK-sensitive target cell line YAC-1 by flow cytometry. Our data show that in vivo application of MT can double the cytotoxic activity against malignant disease and suggest that one mechasim of action of MT is the induction of LAK-cell mediated immune response.

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Dang, Song, Qiaoling Liu, Xuejie Zhang, Kangmin He, Chunru Wang, and Xiaohong Fang. "Comparative Cytotoxicity Study of Water-Soluble Carbon Nanoparticles on Plant Cells." Journal of Nanoscience and Nanotechnology 12, no. 6 (June 1, 2012): 4478–84. http://dx.doi.org/10.1166/jnn.2012.6216.

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Asare, G. A., K. Bugyei, A. Sittie, E. S. Yahaya, B. Gyan, S. Adjei, P. Addo, E. K. Wiredu, D. N. Adjei, and A. K. Nyarko. "Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae)." Genetics and Molecular Research 11, no. 1 (2012): 100–111. http://dx.doi.org/10.4238/2012.january.13.3.

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Tian, Dan-li, Hong Chen, Gang Luo, and Chun-po Liang. "Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin." Chemistry of Natural Compounds 56, no. 6 (November 2020): 994–99. http://dx.doi.org/10.1007/s10600-020-03265-y.

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Riche, Kade, and Natalie R. Lenard. "Quercetin’s Effects on Glutamate Cytotoxicity." Molecules 27, no. 21 (November 7, 2022): 7620. http://dx.doi.org/10.3390/molecules27217620.

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The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown to be preventative against many forms of neuronal cell death resulting from glutamate excitotoxicity, such as oncosis, intrinsic apoptosis, mitochondrial permeability transition, ferroptosis, phagoptosis, lysosomal cell death, parthanatos, and death by reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation. The clinical importance for the attenuation of glutamate excitotoxicity arises from the need to deter the continuous formation of tissue infarction caused by various neurological diseases, such as ischemic stroke, seizures, neurodegenerative diseases, and trauma. This review aims to summarize what is known concerning glutamate physiology and glutamate excitotoxic pathophysiology and provide further insight into quercetin’s potential to hinder neuronal death caused by cell death pathways activated by glutamate excitotoxicity. Quercetin’s bioavailability may limit its use clinically, however. Thus, future research into ways to increase its bioavailability are warranted.

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Vasanth M P, Purushotham KG, Sathish M, Vimal Raj D, and Venkatesh M. "In-vitro Anti-inflammatory activity of Liquorice (Glycyrrhiza glabra) using Aqueous Extract." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (January 21, 2020): 657–62. http://dx.doi.org/10.26452/ijrps.v11i1.1872.

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The G.glabra is otherwise called liquorice is a medicinal plant is used for various diseases like cold, cough, hypokalemia and muscle weakness, etc. The liquorice family belongs to the Fabaceae family of the G.glabra. Hence this study tells about the anti-inflammatory and antioxidants. The quantitative study of phytochemical analysis, antioxidant and Anti-inflammatory, cytotoxicity assay using a response from the root extract of G.glabra The results are showed above preliminary activity phytochemicals were present Alkaloids, Flavonoids, Coumarin, Saponins, Terpenoids, Steroids, Cardiac Glycosides. The antioxidant activity of aqueous extract of G. glabra were evaluated with the 2,2-diphenyl-1-picryl hydrazyl (DPPH), nitric oxide radical (NO), superoxide radical (SO), hydrogen peroxide radical (H2O2), and hydroxyl radical (HO) scavenging activity. This study shows about the activity of Glycyrrhiza glabra herbal medicinal plant aqueous extract using antioxidant assays, Anti-inflammatory assays. The in vitro MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Cytotoxicity assay were studied GG(G.glabra) extract using the macrophages Raw 246.7 Cell line. The cell line assay were studied in two different activity. One is anti-inflammation studies, and another is cytotoxicty of GG aqueous extract. The anti-inflammation IC50 value is 143.65, and GG extract dry sample were against the IC50 value is 326.27. From above, the results were a potential activity of GG extract R-value 0f 0.991.

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Dusan, Vukmirovic, Rollo Dave, Seymour Colin, and Mothersill Carmel. "Cytotoxic Profiling of Plant Secondary Metabolites on P53 Variant Human Colon Carcinoma Cell Lines." Dose-Response 15, no. 4 (October 1, 2017): 155932581774812. http://dx.doi.org/10.1177/1559325817748121.

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Chemoprevention strategies employ the use of compounds to inhibit the initiation, promotion, and progression phases of carcinogenesis. The successful chemopreventative candidate must therefore (1) selectively inhibit growth of transformed cells and (2) be administered on a frequent basis to confer maximal protection. Phytochemicals are a subclass of bioactive plant secondary metabolites that exhibit antioxidative, anticarcinogenic, and anti-inflammatory properties contributing to proper cell function. To assess the effectiveness of these compounds warrants an understanding of their cytotoxic mode of action. In this study, p53 variant human colon carcinoma cell lines were chronically exposed to varying concentrations of the phytochemicals—curcumin, andrographolide, and d-limonene—to determine the role of p53-induced cytotoxicity, with p53-mutant and p53-deficient cell lines representing precancerous lesions. Cytotoxicity was assessed using clonogenic assays and macroscopic colony counts were used to quantify cell survival. The results demonstrate that each phytochemical exhibits selective cytotoxicity toward nonfunctional p53 cell lines, suggesting a p53-mediated role in inhibition of cell clonogenicity and potential chemopreventative properties. Although each compound displays this described effect, only the d-limonene demonstrates considerable chemoprotection, suggesting it might have practical implications in vivo.

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Neerugatti, Dora Babu, Ganga Rao Battu, and Raviteja Bandla. "CYTOTOXICITY ACTIVITY OF SOME INDIAN MEDICINAL PLANTS." International Journal of Current Pharmaceutical Research 8, no. 4 (October 18, 2016): 57. http://dx.doi.org/10.22159/ijcpr.2016v8i4.15279.

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Objective: The current study is carried out to evaluate cytotoxicity activity of the methanolic extracts of some medicinal (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz).Methods: Cytotoxicity activity was evaluated on human cancer cell lines such as lung cancer (A549) and skin cancer (A431) using MTT assay method.Results: The selected plant extracts showed the dose-dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for tested plants extracts. The cytotoxicity of the extracts was increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines. Conclusion: The results of the present study supported the folkloric usage of the studied plants and confirmed that the plant's extracts have the bioactive constituents with cytotoxic properties and their isolation can be useful for developing new anticancer drugs.

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Neerugatti, Dora Babu, Ganga Rao Battu, and Raviteja Bandla. "CYTOTOXICITY ACTIVITY OF SOME INDIAN MEDICINAL PLANTS." International Journal of Current Pharmaceutical Research 8, no. 4 (October 18, 2016): 86. http://dx.doi.org/10.22159/ijcpr.2016v8i4.15687.

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Objective: The current study is carried out to evaluate cytotoxicity activity of the methanolic extracts of some medicinal plants (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz).Methods: Cytotoxicity activity was evaluated on human cancer cell lines such as lung cancer (A549) and skin cancer (A431) using MTT assay method.Results: The selected plant extracts showed the dose-dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for tested plants extracts. The cytotoxicity of the extracts was increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines.Conclusion: The results of the present study supported the folkloric usage of the studied plants and confirmed that the plant's extracts have the bioactive constituents with cytotoxic properties and their isolation can be useful for developing new anticancer drugs.

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Jin, Jian, Yiyi Shan, Liangliang Zhang, Zhengchang Wu, Shenglong Wu, Mingan Sun, and Wenbin Bao. "Pterostilbene Ameliorates Fumonisin B1-Induced Cytotoxic Effect by Interfering in the Activation of JAK/STAT Pathway." Antioxidants 11, no. 12 (November 28, 2022): 2360. http://dx.doi.org/10.3390/antiox11122360.

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Fumonisin B1 (FB1) is a mycotoxin that poses a great threat to agricultural production and the health of humans and animals. Pterostilbene (PTE) is a natural plant polyphenolic compound with good anti-inflammatory, antioxidant and cell regeneration effects, yet its effectiveness in treating FB1-induced cytotoxicity remains to be explored. In this study, we used porcine alveolar macrophages (3D4/21) as a model to characterize the cytotoxicity induced by FB1, and to investigate the potential alleviating effect of PTE on FB1-induced cytotoxicity. We demonstrate that FB1 induces cytotoxicity, apoptosis, pro-inflammatory cytokine production and mitochondrial damage, which can be largely recovered by PTE treatment, suggesting the promising application of PTE to treat FB1-induced damage. Mechanistically, FB1 activates the JAK/STAT signaling pathway, while PTE attenuates FB1-induced cytotoxicity through the inhibition of key JAK/STAT genes such as JAK2 and STAT3. Overall, our study characterized the molecular mechanism for FB1-induced cytotoxicity and found PTE to be a promising component which can alleviate FB1-induced cytotoxicity by interfering in the activation of JAK/STAT pathway.

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Sheela, S. Margrat, and J. Rosaline Vimala. "Proximate Analysis, Antoxidant Property and Cytotoxicity Assessment for Pseuderanthemum Reticulatum Leaves." Oriental Journal Of Chemistry 37, no. 4 (August 30, 2021): 984–90. http://dx.doi.org/10.13005/ojc/370428.

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The bioactive constituents derived from plants attract the attention of researchers due to their potential applications in the medicinal field. In this regard, the proximate analysis and the cytotoxicity study of the plant materials play an important role in the phytochemical research. In the present work, estimation of total ash, moisture content, fiber content, crude protein, and carbohydrate were carried out under proximate analysis and the antioxidant activity of the anthocyanin present in the plant material was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The separation of anthocyanin pigment from the plant material was done by paper chromatography (PC) technique and they are characterized by UV spectrum, chemical test and the Rf values obtained from paper chromatography. This study also investigated the in vitro cytotoxicity of Pseuderanthemum reticulatum leaves by means of MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)) assay PBMC (Peripheral Blood Mononuclear Cell). The results of the proximate analysis showed that the plant material contains 7.6% of moisture content, 16.6 % of total ash, 5.6% of crude protein, 23.0% of crude fiber, 3.82% of crude fat and 23.64 % of carbohydrate. The free radical scavenging ability of the separated anthocyanin was found to be 72.58% at 10 µg/mL. The cytotoxicity investigation showed that the aqueous extract possess the IC50 value of 161.5μg/mL. The High percentage of radical scavenging activity and low toxicity of the plant suggest that it can be extensively used for the investigation of the bioactive constituents and its applications.

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Journal articles on the topic 'Plant cytotoxicity'

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