Relevant bibliographies by topics / Plant lignan

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Plant lignan'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Plant lignan"

1

Bolvig, Anne Katrine, Herman Adlercreutz, Peter Kappel Theil, Henry Jørgensen, and Knud Erik Bach Knudsen. "Absorption of plant lignans from cereals in an experimental pig model." British Journal of Nutrition 115, no. 10 (March 22, 2016): 1711–20. http://dx.doi.org/10.1017/s0007114516000829.

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AbstractPlant lignans are diphenolic compounds ingested with whole grains and seeds and converted to enterolignans by the colonic microbiota. In the present study, we investigated absorption and metabolism of plant lignans and enterolignansin vivoafter consumption of cereal-based diets. Six pigs fitted with catheters in the mesenteric artery and portal vein and with a flow probe attached to the portal vein along with twenty pigs for quantitative collection of urine were used for this study. The animals were fed bread based on wheat flour low in plant lignans and three lignan-rich breads based on whole-wheat grain, wheat aleurone flour or rye aleurone flour. Plant lignans and enterolignans in plasma were monitored daily at fast after 0–3 d of lignan-rich intake, and on the 4th day of lignan-rich intake a 10-h profile was completed. Urine samples were collected after 11 d of lignan-rich diet consumption. The concentrations of plant lignans were low at fast, and was 1·2–2·6 nmol/l after switching from the low-lignan diet to the lignan-rich diets. However, on the profile day, the concentration and quantitative absorption of plant lignans increased significantly from 33 nmol/h at fast to 310 nmol/h 0–2·5 h after ingestion with a gradual increase in the following periods. Quantitatively, the absorption of plant lignans across diets amounted to 7 % of ingested plant lignans, whereas the urinary excretion of plant lignans was 3 % across diets. In conclusion, there is a substantial postprandial uptake of plant lignans from cereals, suggesting that plant lignans are absorbed from the small intestine.
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Hamade, Kamar, Ophélie Fliniaux, Jean-Xavier Fontaine, Roland Molinié, Elvis Otogo Nnang, Solène Bassard, Stéphanie Guénin, et al. "NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax." Molecules 26, no. 3 (February 2, 2021): 767. http://dx.doi.org/10.3390/molecules26030767.

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Lignans, phenolic plant secondary metabolites, are derived from the phenylpropanoid biosynthetic pathway. Although, being investigated for their health benefits in terms of antioxidant, antitumor, anti-inflammatory and antiviral properties, the role of these molecules in plants remains incompletely elucidated; a potential role in stress response mechanisms has been, however, proposed. In this study, a non-targeted metabolomic analysis of the roots, stems, and leaves of wild-type and PLR1-RNAi transgenic flax, devoid of (+) secoisolariciresinol diglucoside ((+) SDG)—the main flaxseed lignan, was performed using 1H-NMR and LC-MS, in order to obtain further insight into the involvement of lignan in the response of plant to osmotic stress. Results showed that wild-type and lignan-deficient flax plants have different metabolic responses after being exposed to osmotic stress conditions, but they both showed the capacity to induce an adaptive response to osmotic stress. These findings suggest the indirect involvement of lignans in osmotic stress response.
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Milder, Ivon E. J., Ilja C. W. Arts, Betty van de Putte, Dini P. Venema, and Peter C. H. Hollman. "Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol." British Journal of Nutrition 93, no. 3 (March 2005): 393–402. http://dx.doi.org/10.1079/bjn20051371.

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Enterolignans (enterodiol and enterolactone) can potentially reduce the risk of certain cancers and cardiovascular diseases. Enterolignans are formed by the intestinal microflora after the consumption of plant lignans. Until recently, only secoisolariciresinol and matairesinol were considered enterolignan precursors, but now several new precursors have been identified, of which lariciresinol and pinoresinol have a high degree of conversion. Quantitative data on the contents in foods of these new enterolignan precursors are not available. Thus, the aim of this study was to compile a lignan database including all four major enterolignan precursors. Liquid chromatography–tandem mass spectrometry was used to quantify lariciresinol, pinoresinol, secoisolariciresinol and matairesinol in eighty-three solid foods and twenty-six beverages commonly consumed in The Netherlands. The richest source of lignans was flaxseed (301 129 μg/100 g), which contained mainly secoisolariciresinol. Also, lignan concentrations in sesame seeds (29 331 μg/100 g, mainly pinoresinol and lariciresinol) were relatively high. For grain products, which are known to be important sources of lignan, lignan concentrations ranged from 7 to 764 μg/100 g. However, many vegetables and fruits had similar concentrations, because of the contribution of lariciresinol and pinoresinol.Brassicavegetables contained unexpectedly high levels of lignans (185–2321 μg/100 g), mainly pinoresinol and lariciresinol. Lignan levels in beverages varied from 0 (cola) to 91 μg/100 ml (red wine). Only four of the 109 foods did not contain a measurable amount of lignans, and in most cases the amount of lariciresinol and pinoresinol was larger than that of secoisolariciresinol and matairesinol. Thus, available databases largely underestimate the amount of enterolignan precursors in foods.
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Park, Woo Sung, Kyung Ah Koo, Ji-Yeong Bae, Hye-Jin Kim, Dong-Min Kang, Ji-Min Kwon, Seung-Mann Paek, Mi Kyeong Lee, Chul Young Kim, and Mi-Jeong Ahn. "Dibenzocyclooctadiene Lignans in Plant Parts and Fermented Beverages of Schisandra chinensis." Plants 10, no. 2 (February 13, 2021): 361. http://dx.doi.org/10.3390/plants10020361.

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The fruit of Schisandra chinensis, Omija, is a well-known traditional medicine used as an anti-tussive and anti-diarrhea agent, with various biological activities derived from the dibenzocyclooctadiene-type lignans. A high-pressure liquid chromatography-diode array detector (HPLC-DAD) method was used to determine seven lignans (schisandrol A and B, tigloylgomisin H, angeloylgomisin H, schisandrin A, B, and C) in the different plant parts and beverages of the fruit of S. chinensis grown in Korea. The contents of these lignans in the plant parts descended in the following order: seeds, flowers, leaves, pulp, and stems. The total lignan content in Omija beverages fermented with white sugar for 12 months increased by 2.6-fold. Omija was fermented for 12 months with white sugar, brown sugar, and oligosaccharide/white sugar (1:1, w/w). The total lignan content in Omija fermented with oligosaccharide/white sugar was approximately 1.2- and 1.7-fold higher than those fermented with white sugar and brown sugar, respectively. A drink prepared by immersion of the fruit in alcohol had a higher total lignan content than these fermented beverages. This is the first report documenting the quantitative changes in dibenzocyclooctadiene-type lignans over a fermentation period and the effects of the fermentable sugars on this eco-friendly fermentation process.
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Szopa, Agnieszka, Michał Dziurka, Angelika Warzecha, Paweł Kubica, Marta Klimek-Szczykutowicz, and Halina Ekiert. "Targeted Lignan Profiling and Anti-Inflammatory Properties of Schisandra rubriflora and Schisandra chinensis Extracts." Molecules 23, no. 12 (November 27, 2018): 3103. http://dx.doi.org/10.3390/molecules23123103.

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Schisandra rubriflora is a dioecious plant of increasing importance due to its lignan composition, and therefore, possible therapeutic properties. The aim of the work was lignan profiling of fruits, leaves and shoots of female (F) and male (M) plants using UHPLC-MS/MS. Additionally, the anti-inflammatory activity of plant extracts and individual lignans was tested in vitro for the inhibition of 15-lipooxygenase (15-LOX), phospholipases A2 (sPLA2), cyclooxygenase 1 and 2 (COX-1; COX-2) enzyme activities. The extracts of fruits, leaves and shoots of the pharmacopoeial species, S. chinensis, were tested for comparison. Twenty-four lignans were monitored. Lignan contents in S. rubriflora fruit extracts amounted to 1055.65 mg/100 g DW and the dominant compounds included schisanhenol, aneloylgomisin H, schisantherin B, schisandrin A, gomisin O, angeloylgomisin O and gomisin G. The content of lignan in leaf extracts was 853.33 (F) and 1106.80 (M) mg/100 g DW. Shoot extracts were poorer in lignans—559.97 (F) and 384.80 (M) mg/100 g DW. Schisantherin B, schisantherin A, 6-O-benzoylgomisin O and angeloylgomisin H were the dominant compounds in leaf and shoot extracts. The total content of detected lignans in S. chinensis fruit, leaf and shoot extracts was: 1686.95, 433.59 and 313.83 mg/100 g DW, respectively. Gomisin N, schisandrin A, schisandrin, gomisin D, schisantherin B, gomisin A, angeloylgomisin H and gomisin J were the dominant lignans in S. chinensis fruit extracts were. The results of anti-inflammatory assays revealed higher activity of S. rubriflora extracts. Individual lignans showed significant inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes.
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Rodríguez-García, Carmen, Cristina Sánchez-Quesada, Estefanía Toledo, Miguel Delgado-Rodríguez, and José Gaforio. "Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?" Molecules 24, no. 5 (March 6, 2019): 917. http://dx.doi.org/10.3390/molecules24050917.

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Dietary guidelines universally advise adherence to plant-based diets. Plant-based foods confer considerable health benefits, partly attributable to their abundant micronutrient (e.g., polyphenol) content. Interest in polyphenols is largely focused on the contribution of their antioxidant activity to the prevention of various disorders, including cardiovascular disease and cancer. Polyphenols are classified into groups, such as stilbenes, flavonoids, phenolic acids, lignans and others. Lignans, which possess a steroid-like chemical structure and are defined as phytoestrogens, are of particular interest to researchers. Traditionally, health benefits attributed to lignans have included a lowered risk of heart disease, menopausal symptoms, osteoporosis and breast cancer. However, the intake of naturally lignan-rich foods varies with the type of diet. Consequently, based on the latest humans’ findings and gathered information on lignan-rich foods collected from Phenol Explorer database this review focuses on the potential health benefits attributable to the consumption of different diets containing naturally lignan-rich foods. Current evidence highlight the bioactive properties of lignans as human health-promoting molecules. Thus, dietary intake of lignan-rich foods could be a useful way to bolster the prevention of chronic illness, such as certain types of cancers and cardiovascular disease.
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Petit, Hélène V. "Antioxidants and dairy production: the example of flax." Revista Brasileira de Zootecnia 38, spe (July 2009): 352–61. http://dx.doi.org/10.1590/s1516-35982009001300035.

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This manuscript reports on the main problems decreasing productivity of dairy cows (e.g. fatty liver syndrome and poor fertility) and how antioxidants could enhance it. High producing dairy cows are prone to oxidative stress, and the situation can be exacerbated under certain environmental, physiological, and dietary conditions. Antioxidants have important effects on the expression of genes involved in the antioxidant status, which may enhance animal health and reproduction. Moreover, antioxidants may contribute to decrease the incidence of spontaneous oxidized flavour in milk enriched in polyunsaturated fatty acids. Plant lignans are strong antioxidants and flax is the richest source of plant lignans. Flax lignans are converted in the mammalian lignans enterolactone and enterodiol. The main mammalian lignan in milk is enterolactone and flax lignans are converted in enterolactone mainly under the action of ruminal microbiota. Therefore, ruminal microbiota may be the most important flora to target for plant lignan metabolism in order to increase concentration of mammalian lignan antioxidants in milk of dairy cows. However, more research is required to improve our knowledge on metabolism of other antioxidants in dairy cows and how they can contribute in decreasing milk oxidation.
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Xu, Xuan, Cédric Guignard, Jenny Renaut, Jean-Francois Hausman, Edoardo Gatti, Stefano Predieri, and Gea Guerriero. "Insights into Lignan Composition and Biosynthesis in Stinging Nettle (Urtica dioica L.)." Molecules 24, no. 21 (October 26, 2019): 3863. http://dx.doi.org/10.3390/molecules24213863.

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Stinging nettle (Urtica dioica L.) has been used as herbal medicine to treat various ailments since ancient times. The biological activity of nettle is chiefly attributed to a large group of phenylpropanoid dimers, namely lignans. Despite the pharmacological importance of nettle lignans, there are no studies addressing lignan biosynthesis in this plant. We herein identified 14 genes encoding dirigent proteins (UdDIRs) and 3 pinoresinol-lariciresinol reductase genes (UdPLRs) in nettle, which are two gene families known to be associated with lignan biosynthesis. Expression profiling of these genes on different organs/tissues revealed a specific expression pattern. Particularly, UdDIR7, 12 and 13 displayed a remarkable high expression in the top internode, fibre tissues of bottom internodes and roots, respectively. The relatively high expression of UdPLR1 and UdPLR2 in the young internodes, core tissue of bottom internode and roots is consistent with the high accumulation of lariciresinol and secoisolariciresinol in these tissues. Lignan quantification showed a high abundance of pinoresinol in roots and pinoresinol diglucosides in young internodes and leaves. This study sheds light on lignan composition and biosynthesis in nettle, providing a good basis for further functional analysis of DIRs and PLRs and, ultimately, engineering lignan metabolism in planta and in cell cultures.
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Kim, A.-Young, Choong-In Yun, Joon-Goo Lee, and Young-Jun Kim. "Determination and Daily Intake Estimation of Lignans in Sesame Seeds and Sesame Oil Products in Korea." Foods 9, no. 4 (March 30, 2020): 394. http://dx.doi.org/10.3390/foods9040394.

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Sesame (Sesamum indicum L.) is a plant that belongs to the Pedaliaceae family which was first classified as a food source around 4000 years ago. Lignans (sesamin, sesamolin, sesamol, and sesaminol) present in sesame are the primary functional compounds that impart important health benefits. However, very little information is available on the lignan intake from sesame seeds and sesame oil products. Sesame oil is frequently and highly consumed in Korea and therefore is one of the important lignan intake sources due to the food eating habits of Koreans. Herein, we studied the distribution of lignans in sesame seeds (n = 21) and oil (n = 34) to estimate the daily lignan intake by the Korean population. High-performance liquid chromatography, in conjunction with statistical analysis, was used to determine the lignan content of seeds and oil. The estimated daily intake of total lignans from sesame seeds and oil, as estimated from the available domestic consumption data (Korea Nutrition and Health Examination Survey), is 18.39 mg/person/day for males and 13.26 mg/person/day for females. The contributions of lignan intake from sesame seeds and oil are 23.0% and 77.0%, respectively. This study provides preliminary information on lignan intake from sesame seeds and oil in the Korean population.
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Lampe, Johanna W., Charlotte Atkinson, and Meredith A. J. Hullar. "Assessing Exposure to Lignans and Their Metabolites in Humans." Journal of AOAC INTERNATIONAL 89, no. 4 (July 1, 2006): 1174–81. http://dx.doi.org/10.1093/jaoac/89.4.1174.

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Abstract Phytoestrogens occur naturally in plants and are structurally similar to mammalian estrogens. The lignans are a class of phytoestrogen and can be metabolized to the biologically active enterolignans, enterodiol, and enterolactone by a consortium of intestinal bacteria. Secoisolariciresinol diglucoside (SDG), a plant lignan, is metabolized to enterodiol and, subsequently, enterolactone. Matairesinol, another plant lignan, is metabolized to enterolactone. Other dietary enterolignan precursors include lariciresinol, pinoresinol, syringaresinol, arctigenin, and sesamin. Enterolignan exposure is determined in part by intake of these precursors, gut bacterial activity, and host conjugating enzyme activity. A single SDG dose results in enterolignan appearance in plasma 810 h latera timeframe associated with colonic bacterial metabolism and absorption. Conjugation of enterolignans with sulfate and glucuronic acid occurs in the intestinal wall and liver, with the predominant conjugates wall and liver, with the predominant conjugates have demonstrated dose-dependent urinary lignan excretion in response to flaxseed consumption (a source of SDG); however, even in the context of controlled studies, there is substantial interindividual variation in plasma concentrations and urinary excretion of enterolignans. The complex interaction between colonic environment and external and internal factors that modulate it likely contribute to this variation. Knowledge of this field, to date, indicates that understanding the sources of variation and measuring the relevant panel of compounds are important in order to use these measures effectively in evaluating the impact of lignans on human health.
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Dissertations / Theses on the topic "Plant lignan"

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Mabrok, Hoda Hussein Bakr. "Protective role of lignan-converting bacteria on chemically-induced breast cancer in gnotobiotic rats." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6493/.

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Enterolignans (enterodiol and enterolactone) exhibit structural similarity to estradiol and have therefore been hypothesized to modulate hormone related cancers such as breast cancer. The bioactivation of the plant lignan secoisolariciresinol diglucoside (SDG) requires the transformation by intestinal bacteria including the deglycosylation of SDG to secoisolariciresinol (SECO) followed by demethylation and dehydroxylation of SECO to enterodiol (ED). Finally, ED is dehydrogenated to enterolactone (EL). It is unclear whether the bacterial activation of SDG to ED and EL is crucial for the cancer preventing effects of dietary lignans. The possible protective effect of bacterial lignan transformation on a 7,12 dimethylbenz(a)anthracene (DMBA)-induced breast cancer in gnotobiotic rats was investigated. Germ-free rats were associated with a defined lignan-converting consortium (Clostridium saccharogumia, Blautia producta, Eggerthella lenta, and Lactonifactor longoviformis). The rats colonized with lignan-converting bacteria consortium (LCC) were fed a lignan-rich flaxseed diet and breast cancer was chemical induced. Identically treated germ-free rats served as control. All bacteria of the consortium successfully colonized the intestine of the LCC rats. The plant lignan SDG was converted into the enterolignans ED and EL in the LCC rats but not in the germ-free rats. This transformation did not influence cancer incidence but significantly decreased tumor numbers per tumor-bearing rat, and tumor size. Cell proliferation was significantly inhibited and apoptosis was significantly induced in LCC rats. No differences between LCC and control rats were observed in the expression of the genes encoding the estrogen receptors (ERα and ERβ) and G-coupled protein receptor 30 (GPR30). Similar findings were observed for both insulin-like growth factor 1 (IGF-1) and epidermal growth factor receptor (EGFR) genes involved in tumor growth. Proteome analysis revealed that 24 proteins were differentially expressed in tumor tissue from LCC and germ-free. RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) and poly(rC)-binding protein 1 (PBCP1) were down-regulated by 3.2- and 2.0-fold, respectively. These proteins are associated with cell proliferation. The activity of selected enzymes involved in the degradation of oxidants in plasma and liver was significantly increased in the LCC rats. However, plasma and liver concentrations of reduced glutathione (non-enzymatic antioxidant) and malondialdehyde (oxidative stress marker) did not differ between the groups. In conclusion, the bacterial conversion of plant lignan to enterolignans beneficially influences their anti-cancer effect. However, the mechanisms involved in these effects remain elusive.
Enterolignanen (Enterodiol ED und Enterolacton EL) wird aufgrund ihrer strukturellen Ähnlichkeit zu Estradiol ein modulierender Einfluss auf hormonell bedingte Krebserkrankungen wie Brustkrebs nachgesagt. Das pflanzliche Lignan Secoisolariciresinoldiglucosid (SDG) wird durch Darmbakterien zum Enterolignan aktiviert. Dies erfolgt über dessen Deglykosylierung zu Secoisolariciresinol (SECO) gefolgt durch die Demethylierung und die Dehydroxylierung zu Enterodiol (ED). Schließlich wird ED zu Enterolacton (EL) dehydrogeniert. Es ist allerdings noch nicht bewiesen, dass die bakterielle Aktivierung von SDG zu ED und EL für die antikanzerogenen Wirkungen verantwortlich ist, die für dieses in der menschlichen Ernährung vorkommende Lignan beschrieben wurden. Um dies zu klären, wurde der Einfluss der bakteriellen Lignan-Transformation auf die Protektion gegenüber einem durch 7,12-Dimethylbenz(a)anthracen (DMBA)-induzierten Brustkrebs im gnotobiotischen Rattenmodell untersucht. Keimfreie Ratten wurden hierfür mit einem Konsortium aus vier Bakterienstämmen (Clostridium saccharogumia, Blautia producta, Eggerthella lenta, und Lactonifactor longoviformis) besiedelt, das die Umsetzung von SDG zu ED und EL katalysiert (LCC-Ratten). Ratten, die über den gesamten Versuchszeitraum keimfrei blieben, dienten als Kontrolle. Die Tiere wurden über 16 Wochen mit einer Leinsamen-Diät gefüttert, die reich an pflanzlichen Lignanen war. Während der Fütterung wurde bei allen Tieren Brustkrebs chemisch induziert. Das pflanzliche Lignan SDG wurde nur in den LCC Ratten zu den Enterolignanen ED und EL umgewandelt. Keimfreie Ratten zeigten keine Transformation von SDG. Die bakterielle Transformation von SDG hatte zwar keinen Einfluss auf die Inzidenz von Brustkrebs, jedoch verringerten sich durch die Besiedlung der Ratten mit SDG-transformierenden Bakterien die Anzahl von Tumoren pro tumortragender Ratte und die Tumorgröße deutlich. Zudem wurde die Zellproliferation in den LCC-Ratten deutlich gehemmt und die Apoptose induziert. Unterschiede in der Genexpression der Östrogenrezeptoren (ERα und ERß) und G-Protein-gekoppelte Rezeptoren (GPR30) wurden zwischen den LCC-Ratten und den Kontrolltieren nicht beobachtet. Ebenso verhielt es sich für die Gene des Insulinähnliche Wachstumsfaktoren 1 (IGF-1) und Epidermale Wachstumsfaktor rezeptoren (EGFR), welche in das Tumorwachstum involviert sind. Die Analyse des Proteoms des Tumorgewebes ergab 24 differentiell exprimierte Proteine zwischen keimfreien und LCC-Ratten. So wurden zum Beispiel die Proteine RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) und poly(rC)-binding protein 1 (PBCP1), die mit der Zellproliferation assoziiert sind, in LCC-Ratten um das 3,2 bzw. 2,0-fache herunterreguliert. Die Aktivität ausgewählter antioxidativer Enzyme in Plasma und Leber war in den LCC-Ratten im Vergleich zu den keimfreien Tieren deutlich erhöht. Allerdings unterschieden sich die Konzentrationen von reduziertem Glutathion (nichtenzymatisches Antioxidans) und Malondialdehyd (oxidativer Stress-Marker) in Plasma und Leber nicht zwischen den beiden Besiedlungs-Gruppen. Zusammenfassend zeigen die Ergebnisse, dass die bakterielle Umwandlung von pflanzlichen Lignanen zu Enterolignanen deren antikanzerogene Wirkung entscheidend beeinflusst. Allerdings bleiben die zugrunde liegenden Mechanismen weiterhin ungeklärt.
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Okunishi, Tomoya. "Stereochemistry of Lignan Biosynthesis in Thymelaeaceae Plants." Kyoto University, 2003. http://hdl.handle.net/2433/149001.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第10276号
農博第1348号
新制||農||869(附属図書館)
学位論文||H15||N3797(農学部図書室)
UT51-2003-H697
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 島田 幹夫, 教授 桑原 保正, 教授 坂田 完三
学位規則第4条第1項該当
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Dodson, A. P. J. "The use of lignin peroxidases to degrade lignin in plant cell walls." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46747.

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Lamp, Shane B. "Equipment specification, process control, and plant simulation for a lignin-fueled fluidized bed combustor plant." Morgantown, W. Va. : [West Virginia University Libraries], 1998. http://etd.wvu.edu/templates/showETD.cfm?recnum=224.

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Thesis (M.S.)--West Virginia University, 1998.
Title from document title page. Document formatted into pages; contains xv, 98 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 84).
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Vassão, Daniel Giddings. "Biosynthesis of plant allyl/propenyl-phenols and 9,9'-deoxygenated lignans." Pullman, Wash. : Washington State University, 2008. http://www.dissertations.wsu.edu/Dissertations/Fall2008/d_vassao_120908.pdf.

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Lalaleo, Córdova Liliana Paulina. "New biotechnological systems for the research on aryltetralin lignans in Linum album." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/401647.

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Linum album is an herbaceous plant with medical interest due to its content of podophyllotoxin (PTOX), an aryltetralin lignan with cytotoxic activity. The study of biotechnological alternatives has generated big interest. Organ and cell in vitro cultures offer the possibility of suppling aryltetralin lignans in accordance with a sustainable and rational utilization of biodiversity, however they need to be improved. Thus, in this work we analyzed the lignan accumulation patterns in four biotechnological systems of L.album in order to find alternatives of bioproduction. The four biotechnological platforms were established with wild type and transformed cell suspension cultures, adventitious roots isolated from in vitro plants, and hairy roots. The predominant lignan produced by wild type and transformed cells was PTOX. The main lignan produced by adventitious and hairy roots was 6- MPTOX, adventitious roots showed to be more productive, and we can infer that the transformation did not change the lignan patterns. In addition, we have studied the response to the elicitor coronatine in these systems. Transformed cells were the most sensitive after elicitation and showed an arrest of biomass growth in relation to other systems. In general, the elicitation increased the lignan content, but the more elicited route in each system resulted to be the less productive. Transcript profiling changed in elicited conditions, specially for the PLR gene in transformed cells. The analysis of morphogenesis development in the production of podophyllotoxin derivatives in callus cultures of Linum album showed that, the absence of plant growth regulators are a predominant factor, to induce the organogenic and the bioproduction as well. Finally, approaches aiming at increasing podophyllotoxin content require multiple enzymatic steps that facilitate the metabolic flow to the final products, most of them forming multiprotein complexes. Based on this, the Yeast two hibrid system allowed to identify CTB5 as a potential interactor of the PLR protein of Linum album, and evidences in other species indicate that CTB5 participates in the phenylpropanoid pathway.
Linum album es una planta herbácea con interés farmacológico debido a su alto contenido de podofilotoxina (PTOX), el cual es un lignano de característica ariltetralin con actividad citotóxica. El estudio de las alternativas biotecnológicas ha generado gran interés. Los cultivos in vitro de órganos y células ofrecen la posibilidad de suministrar aryltetralin lignanos en acuerdo con una utilización sostenible y racional de la biodiversidad, sin embargo necesitan ser mejorados. Por tanto, en este trabajo se analizaron los patrones de acumulación de lignanos en cuatro sistemas biotecnológicos de L.album con el fin de encontrar alternativas en la bioproducción. Se establecieron cuatro plataformas biotecnológicas con cultivos en suspensión celular de tipo salvaje y transformados, raíces adventicias aisladas de plantas in vitro y raíces en cabellera. La PTOX fue el lignano predominante producido por células de tipo salvaje y transformadas. El principal lignano producido por las raíces adventicias y raíces transgénicas fue la metoxipodofilotoxina (MPTOX), en general las raíces adventicias fueron las más productivas, por lo cual podemos inferir que la transformación no afecto los patrones de bioproducción. Además, hemos estudiado la respuesta a la coronatina como elicitor en estos sistemas, donde las células transformadas fueron las más suceptibles a la elicitación mostrando una disminución en la biomasa en relación con los otros sistemas. En general, la elicitación aumentó el contenido de lignanos, aunque la ruta principal fue las menos favorecida en cada sistema. El perfil de expresión genética elicitadas, especialmente para el gen PLR en las células transformadas. El análisis del desarrollo de la morfogénesis en la producción de derivados de podofilotoxina en cultivos de callos del Linum álbum mostró que la ausencia de reguladores del crecimiento es un factor predominante para inducir la respuesta organogénica y la bioproducción. Finalmente, las aproximaciones que apuntan a aumentar el contenido de podofilotoxina requieren múltiples pasos enzimáticos que faciliten el flujo metabólico hacia los productos finales, la mayoría de ellos formando complejos multiproteicos. Basado en lo anterior, la técnica del doble hibrido en levadura nos permitió identificar la CTB5 como un potencial interactor de la proteína PLR del Linum álbum, hallada en otras especies como interactor en la ruta metabolica de los fenilpropanoides.
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Hoffman, Sister Angela. "Hormonal regulation of cell development and polyphenol biosynthesis in cultured Populus trichocarpa cells /." Full text open access at:, 1989. http://content.ohsu.edu/u?/etd,220.

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Muir, Shelagh R. "Ligand-gated calcium channels in higher plant membranes." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319717.

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Lease, Kevin A. "Erecta and erecta-like mutants of Arabidopsis thaliana /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974650.

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Uden, Wilhelmus van. "The production of podophyllotoxin and related cytotoxic lignans by plant cell cultures." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1992. http://irs.ub.rug.nl/ppn/293040230.

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Books on the topic "Plant lignan"

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Calvo-Flores, Francisco G. Lignin and lignans as renewable raw materials: Chemistry, technology and applications. Chichester, West Sussex: John Wiley and Sons, Inc., 2015.

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Le architetture lignee dei cori: Il settecentesco coro ligneo della Chiesa Madre di Linguaglossa. Roma: Aracne, 2005.

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D, Loike J., ed. Lignans: Chemical, biological, and clinical properties. Cambridge [England]: Cambridge University Press, 1990.

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Koshijima, T. Association between lignin and carbohydrates in wood and other plant tissues. Berlin: Springer, 2003.

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Koshijima, Tetsuo. Association Between Lignin and Carbohydrates in Wood and Other Plant Tissues. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003.

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Koshijima, Tetsuo, and Takashi Watanabe. Association Between Lignin and Carbohydrates in Wood and Other Plant Tissues. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05191-7.

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author, Yin Jun, and Qin Chuixin author, eds. Schisandra chinensis: An herb of north eastern China origin. New Jersey: World Scientific, 2015.

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Tax, Frans. Receptor-like Kinases in Plants: From Development to Defense. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.

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Northern Electric & Mfg. Co. Comment construire les lignes téléphoniques rurales. Montréal: La Compagnie, 1995.

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Ngwiri, Kathleen Webb. Lignes directrices pour la definition des plans d'actions pour 1991-1994. Antananarivo: UNICEF, 1991.

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Book chapters on the topic "Plant lignan"

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Kwon, Mi, Vincent Burlat, Laurence B. Davin, and Norman G. Lewis. "Localization of Dirigent Protein Involved in Lignan Biosynthesis: Implications for Lignification at the Tissue and Subcellular Level." In Plant Polyphenols 2, 393–411. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4139-4_21.

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Moinuddin, Syed G. A., John R. Cort, Clyde A. Smith, Christophe Hano, Laurence B. Davin, and Norman G. Lewis. "Linum Lignan and Associated Biochemical Pathways in Human Health and Plant Defense." In Genetics and Genomics of Linum, 167–93. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23964-0_11.

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Satake, Honoo, Tomotsugu Koyama, Erika Matsumoto, Kinuyo Morimoto, Eiichiro Ono, and Jun Murata. "Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods." In Reference Series in Phytochemistry, 373–98. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28669-3_11.

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Satake, Honoo, Tomotsugu Koyama, Erika Matsumoto, Kinuyo Morimoto, Eiichiro Ono, and Jun Murata. "Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods." In Transgenesis and Secondary Metabolism, 1–26. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27490-4_11-1.

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Kuwahara, M. "Measuring Lignin Degradation." In Plant Fibers, 186–202. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83349-6_10.

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Gottlieb, O. R., and M. Yoshida. "Lignans." In Natural Products of Woody Plants, 439–511. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74075-6_14.

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Davin, Laurence B., and Norman G. Lewis. "Phenylpropanoid Metabolism: Biosynthesis of Monolignols, Lignans and Neolignans, Lignins and Suberins." In Phenolic Metabolism in Plants, 325–75. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3430-3_11.

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Umezawa, T., and T. Higuchi. "Methods Used in the Chemistry of Lignin Biodegradation." In Plant Fibers, 161–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83349-6_9.

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Azuma, Jun-Ichi. "Analysis of Lignin-Carbohydrate Complexes of Plant Cell Walls." In Plant Fibers, 100–126. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83349-6_6.

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Ford, Joshua D., Laurence B. Davin, and Norman G. Lewis. "Plant Lignans and Health: Cancer Chemoprevention and Biotechnological Opportunities." In Plant Polyphenols 2, 675–94. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4139-4_38.

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Conference papers on the topic "Plant lignan"

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Tan Yuen, P., A. Savchenko, N. Broit, G. Boyle, P. Parsons, and C. Williams. "The First Plant Seco-Steroid and a New lignan from the Australian Arid Zone." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608084.

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Lineberger, Claire G., Laura W. Bowers, Nikki A. Ford, Emily L. Rossi, Bruce K. Kimler, Carol J. Fabian, and Stephen D. Hursting. "Abstract 231: The polyphenolic plant lignan secoisolariciresinol diglycoside reduces mammary tumor growth, possibly via inhibition of local inflammatory signaling." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-231.

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Jhu, Min-Yao. "Blocking entry: lignin-based resistance to dodder parasitism." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.365250.

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Liu, Chang. "Identifying receptors for defense signaling in Arabidopsis stems with reduced lignin content." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1052913.

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Kim, Min-Ha. "A Populus MYB transcription factor coordinately regulates both anthocyanin and lignin biosynthesis pathway." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.388597.

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Sulis, Daniel. "Multiplex CRISPR-Based Editing in Lignin Biosynthesis to Improve Poplar for Bioenergy and Bioproducts." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1372284.

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Zhuo, Chunliu. "Moligl biosynthesis and utilization during the switch from G- to C-lignin accumulation in Cleome hassleriana." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.213472.

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Smirnova, E. V., E. V. Ozhimkova, E. M. Korotkova, and I. V. Uschapovsky. "USING OF LIGNIN AS AN ENVIRONMENTALLY GROWTH STIMULANT FOR AGRICULTURAL PLANTS." In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS. DSTU-PRINT, 2020. http://dx.doi.org/10.23947/interagro.2020.1.265-267.

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Abstract:
The effectiveness of using lignin solutions as plant growth stimulants has been studied. As test objects for the study of growth-stimulating activity of lignin solutions, the seeds of cultural flax, an important agricultural crop in the Tver region, were used.
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Belovezhets, L. A., M. S. Tretyakova, and Yu A. Markova. "An integrated approach to design of new biotechnological products to reduce man-induced load on environment." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.040.

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"Role of genes involved in lignin biosynthesis in flax response to Fusarium oxysporum." In Current Challenges in Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Novosibirsk State University, 2019. http://dx.doi.org/10.18699/icg-plantgen2019-26.

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Reports on the topic "Plant lignan"

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Chiang, Vincent L. Modeling of cellulose, hemicellulose and lignin-carbohydrate complex formation and regulation to understand plant cell wall structure. Office of Scientific and Technical Information (OSTI), February 2018. http://dx.doi.org/10.2172/1420055.

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