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Dissertations / Theses on the topic 'Plants, Medicinal – chemistry'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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1

Chen, Dianne Tzu-Hsiu. "Phytochemical studies on traditional medicinal plants with antimalarial activities." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/21853.

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The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51
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2

Habtemariam, Solomon. "Phytochemical and pharmacological investigation of some medicinal plants." Thesis, University of Strathclyde, 1992. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21299.

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This thesis describes phytochemical and biological/pharmacological studies on six medicinal plants. Plant materials were extracted by ethanol, tested for their biological activity and then subjected to "bioassay-guided fractionation" to yield active and inactive compounds. The compounds were identified by standard physico-chemical techniques including UV, IR, NMR and ElMS. The crude ethanol extract of the leaves of Premna shcimperi was found to be antibacterial against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). An antibacterial bioassay-guided fractionation of the ex
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3

Waheed, Abdul. "Isolation and characterisation of potential anticancer compounds from medicinal plants." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22906/.

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The research work presented in this thesis deals with the anticancer activity of four medicinal plants: 'Caralluma tuberculata' (Asclepiadaceae), 'Fagonia indica' (Zygophyllaceae), 'Solanum surattense' (Solanaceae) and 'Arisaema utile' (Araceae) that originate from the North West and Himalayan regions of Pakistan. Through a bioactivity-guided fractionation approach, the crude and resultant organic fractions were tested on cultured breast cancer cells (MCF-7 and MDA MB-468) and colorectal carcinoma cells (Caco-2) in vitro. Five new compounds out of seven in total were isolated from potent fract
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4

Techatanawat, Isariya. "Chemistry and cytotoxic activity of some Thai medicinal plants used to treat cancer." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427990.

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5

Souza, Leonardo Perez de [UNESP]. "Padronização de extratos vegetais: Astronium urundeuva (Anacardiaceae)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/97976.

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Made available in DSpace on 2014-06-11T19:29:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-03-14Bitstream added on 2014-06-13T18:58:42Z : No. of bitstreams: 1 souza_lp_me_araiq.pdf: 965130 bytes, checksum: dbb3a6d9ec846ccdcb7e27caa43c9b5b (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O uso de fitoterápicos padronizados com eficácia e segurança garantidas tem mostrado resultados surpreendes em diversos países. Contudo, o Brasil ainda possui deficiências na correta caracterização dos
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6

Mokgadi, Janes. "Pressurized hot water extraction of nutraceuticals and organic pollutants from medicinal plants." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004999.

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This thesis explores the robustness and the versatility of pressurized hot water extraction (PHWE) for a variety of analytes and matrices. Applications discussed include: selective extraction of alkaloids in goldenseal followed by their degradation studies; in-cell clean-up of pesticides in medicinal plants employing custom made molecularly imprinted polymers (MIPs) sorbents; in-cell pre-concentration followed by desorption of aflatoxins in plants with MIPs; desorption of pesticides from electrospun nanofiber sorbents; and removal of templates from MIPs sorbents. It was demonstrated that selec
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7

Tsui, Wing-yan Pamela. "Phytochemical investigation of plants used in traditional medicine in Hong Kong /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17594303.

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8

Souza, Leonardo Perez de. "Padronização de extratos vegetais : Astronium urundeuva (Anacardiaceae) /." Araraquara : [s.n.], 2012. http://hdl.handle.net/11449/97976.

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Resumo: O uso de fitoterápicos padronizados com eficácia e segurança garantidas tem mostrado resultados surpreendes em diversos países. Contudo, o Brasil ainda possui deficiências na correta caracterização dos produtos brutos e falta de um controle de qualidade mais rigoroso para esses materiais. As etapas necessárias para utilização de uma planta como fitoterápico são, primeiramente, a comprovação da sua eficácia e segurança através de ensaios farmacológicos seguidas da correta caracterização química do extrato e quantificação de alguns marcadores escolhidos para representarem a sua identidad
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9

Swartz, Vuyiswa Gladys. "Phytochemical studies of Helichrysum patulum." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3651_1189147447.

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<p>Since Helichrysum is known by the indigenous people of Africa for therapeutic properties, such as against colds, flu and wounds, the aim of this study was to focus on the patulum species found predominantly in the Western Cape region of South Africa and by means of isolation and identification of the plant constituents, be able to relate the therapeutic activity on the basis of literature precedents, to the compounds extracted.</p>
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10

Liang, Li. "Pharmacognostical studies on Heshouwu (Polygoni Multiflori Radix): textual research, quality evaluation and processing chemistry investigation." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/524.

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Heshouwu, derived from the tuberous root of Polygonum multiflorum Thunb., has been widely used in Traditional Chinese Medicine for centuries. It has a purgative effect when unprocessed, while used as a tonic after processing, and according to historical records, heshouwu should be steamed and sun-dried nine times to generate processed materials. Up until recently, three aspects of heshouwu have not been sufficiently studied. First, it is necessary to understand the history of heshouwu, including the emergence in the literature, the descriptions of its appearance, its effects and controversies,
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11

劉榮光. "龜苓膏與涼粉的指紋圖譜比較". HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1136.

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12

Muhizi, Theoneste. "The extraction, purification and evaluation of compounds from the leaves of Leonotis Leonorus for anticonvulsant activity." Thesis, University of the Western Cape, 2002. http://hdl.handle.net/11394/1609.

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Magister Scientiae - MSc<br>The aim of this study is to isolate and evaluate the anticonvulsant components from the leaves of Leonotis leonorus (L) R.aR. and to see if there is any change in activity with the origin of the plant material and I or the season in which plant material is collected. Therefore, in this study, two sites were chosen for collection of plant material and the collection was made in summer and in winter. Chemical, physical and pharmacological methods were used to isolate, identify and to evaluate compounds isolated from the leaves of Leonotis leonorus for anticonvulsant a
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13

Amaral, Fabiano Pereira do [UNESP]. "Compostos fenólicos de Paepalanthus geniculatus (Eriocaulaceae)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/105826.

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Made available in DSpace on 2014-06-11T19:35:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-06-18Bitstream added on 2014-06-13T21:07:21Z : No. of bitstreams: 1 amaral_fp_dr_araiq.pdf: 4513783 bytes, checksum: e99f12bcbcd5a5642dd150965f5e0fd8 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>No Brasil, 31 espécies vegetais de Paepalanthus foram registradas no Estado de Minas Gerais, no topo da Serra do Espinhaço, o principal centro de diversidade de Eriocaulaceae do Brasil e mais de 400 espécies de Paepalanthus e estão distribuídas geograficamente do
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14

Ali, Marina. "Antimicrobial metabolites from Australian Acacia : thesis /." View thesis, 1998. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030825.144902/index.html.

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15

Reis, Amália Soares dos. "Bioatividade da Quassia amara L. e estabilidade oxidativa sobre o óleo de soja." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2276.

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CAPES<br>A procura cada vez maior por produtos naturais pelos consumidores, leva a uma busca intensificada por antioxidantes naturais, visando a substituição dos antioxidantes sintéticos utilizados pela indústria de alimentos. Essa substituição faz-se necessária devido aos efeitos danosos que essas substâncias causam a saúde. A Quassia amara é uma planta nativa do norte do Brasil, pertencente a família Simaroubaceae e utilizada para combater a malária e problemas gastrointestinais. Este trabalho teve como objetivo otimizar o método de extração de compostos com atividade antioxidante presentes
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16

Diedrich, Camila. "Otimização multivariada de extração de compostos bioativos em folhas, casca e resíduos de seiva de Croton lechleri." Universidade Tecnológica Federal do Paraná, 2018. http://repositorio.utfpr.edu.br/jspui/handle/1/3226.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>As plantas naturais da Amazônia vêm instigando o interesse de pesquisadores a extrair os produtos desta região. O intuito destas pesquisas foca no desenvolvimento de novos fármacos a partir dos compostos bioativos de plantas visando o combate de inúmeras doenças associadas ao aumento na produção de espécies reativas de oxigênio. A seiva, folhas e cascas de plantas do gênero Croton são utilizadas pelos povos nativos amazônicos para fins medicinais com ação cicatrizante, anti-inflamatória e antibacteriana. Este estudo teve co
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17

Okoh, Omobola Oluranti. "Chemical transformations and phytochemical studies of bioactive components from extracts of Rosmarinus officinalis L." Thesis, University of Fort Hare, 2010. http://hdl.handle.net/10353/354.

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Variations in the yield, chemical composition, antibacterial, and antioxidant properties of the essential oils of Rosmarinus officinalis L. cultivated in Alice, Eastern Cape of South Africa over a period of 12 months using the solvent-free microwave extraction and traditional hydrodistillation methods were evaluated. The GC-MS analyses of the essential oils revealed the presence of 33 compounds with 1,8-cineole, a-pinene, camphor, verbenone, bornyl acetate and camphene constituting about 80 percent of the oils throughout the period of investigation, with the solvent-free microwave extraction m
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18

Kabatende, Joseph. "Pharmacological evaluation of some central nervous system effects of Cotyledon Orbiculata." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The use of traditional medicine through the use of medicinal plants in Africa and especially in South Africa has long been considered an important characteristic of people's daily lives and socio-cultural heritage. Cotyledon Orbiculata is among the medicinal plants that are used by South African traditional practitioners for the treatment of epilepsy and painful conditions such as corns, warts, toothache, earache, boils and various other ailments. However, the claim of therapeutic successes of medicinal plants by traditional medicine practitioners are hardly subjected to scientific scrutiny. T
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19

Arruda, Frommenwiler Débora. "Comprehensive high performance thin layer chromatography (HPTLC) fingerprinting in quality control of herbal drugs, preparations and products." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671745.

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Quality control of herbals has its roots in the study of morphoanatomic and organoleptic characters. Nevertheless, in the last century, with the evolution of analytical chemistry, the quality control rapidly evolved from elementary tests to the use of sophisticated instruments combined with software for data management. In the current days, many authorities and organizations recommend a suite of tests, featuring many of these instruments, to evaluate quality of herbal products. HPTLC offers a comprehensive set of data that can be used not only for identification but also to evaluate the purity
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20

Figaro, Anajara Kaczmareck. "O ensino de química e seminário integrado: valorizando a pesquisa do estudante a respeito dos saberes populares das plantas medicinais." Universidade Federal do Pampa, 2015. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1245.

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Submitted by Andrea Pereira (andrea.pereira@unipampa.edu.br) on 2017-03-10T17:19:52Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) ANAJARA FIGARO_DISSERTAÇÃO.pdf: 3785663 bytes, checksum: 7468f9d07bffbaec477dbf71f28acda2 (MD5)<br>Approved for entry into archive by Andrea Pereira (andrea.pereira@unipampa.edu.br) on 2017-03-10T17:20:16Z (GMT) No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) ANAJARA FIGARO_DISSERTAÇÃO.pdf: 3785663 bytes, checksum: 7468f9d07bffbaec477dbf71f28acda2 (MD5)<br>Made avai
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21

Ferreira, Edgard Antonio. "2-Acil-cicloexano-1,3-dionas de Peperomia trineura (Miq.)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-06102009-132951/.

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O extrato bruto da planta inteira (Peperomia trineura) foi submetido à cromatografia de adsorção em sílica gel, cromatografia em camada delgada preparativa (CCDP) e CLAE semipreparativa, resultando no isolamento de cinco policetídeos inéditos em função do comprimento ou presença da insaturação na cadeia alquílica. A elucidação estrutural destes policetídeos foi realizada com base nas analises espectroscópicas de RMN 1D e 2D, infravermelho e espectrometria de massas de baixa e alta resolução. As frações provenientes do extrato bruto foram testadas frente a duas linhagens de células leucêmicas (
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22

Adams, Zanele. "Comparative phytochemical analyses of Aloe Ferox Mill. found in Eastern and Western Cape provinces in South Africa." Thesis, University of Fort Hare, 2013. http://hdl.handle.net/10353/d1013114.

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23

任黛. "篦子三尖杉的化學成分研究". Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952202.

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24

Emilia, Gligorić. "Biološki potencijal i hemijska analiza vrsta roda Salix L. (Salicaceae) sa teritorije Republike Srbije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=107862&source=NDLTD&language=en.

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Rod Salix pripada porodici Salicaceae i obuhvata oko 450 vrsta &scaron;irom sveta, od kojih u Republici Srbiji raste oko 18. Kora vrbe ispoljava antiinflamatorno, antireumatsko, analgetičko i antipiretičko delovanje sinergističkim efektom njenih glavnih aktivnih supstanci &ndash; glikozida salicina, fenolnih i flavonoidnih jedinjenja. Ciljevi ovog rada bili su ispitivanje uticaja klasične i savremenih metoda ekstrakcije na hemijski sastav i biolo&scaron;ke aktivnosti ekstrakata različitih vrsta vrba, utvrđivanje razlika u sadržaju aktivnih komponenti i biolo&scaron;kom potencijalu između ekstr
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25

Chau, Yasmin-Pei(Yasmin-Pei Kamal). "Biosynthesis and medicinal chemistry of therapeutically promising plant natural products." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122839.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Modern molecular biology, biochemical, and chemical techniques have made it possible to identify individual natural products that possess pharmacological activity from medicinal plants. While approximately 50% of all new FDA-approved small molecule therapeutics in the past 40 years were natural products or natural product analogs, challenges including limited natural resources and the difficulty of solving the tota
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26

Lima, Rafaely Nascimento. "Caracterização química dos óleos essenciais e extratos supercríticos de três espécies de Piper de Sergipe." Pós-Graduação em Química, 2014. https://ri.ufs.br/handle/riufs/6097.

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To contribute to the knowledge of the chemical species P. klotzschianum, P. hispidum and P. arboreum, analyzes of volatile obtained by hydrodistillation-(HD), extracts obtained by supercritical fluid extraction-(SFE) and identification of isolated compounds were performed using techniques such as GC/MS/FID, NMR (1D, 2D) and IV. Sesquiterpenes present in P. klotzschianum, P. hispidum and P. arboreum as the (E)-caryophyllene, bicyclogermacrene and germacrene D observed only in P.hispidum and P. klotzschianum were the main substances responsible for the high values obtained sesquiterpenes identif
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27

Yee, Melinda Chua Fui. "An investigation of the biology and chemistry of the Chinese medicinal plant, Amorphophallus konjac." Thesis, University of Wolverhampton, 2011. http://hdl.handle.net/2436/237603.

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Konjac glucomannan (KGM), the main biologically active constituent of konjac flour extracted from corms of Amorphophallus konjac (konjac), can be used to prepare functional foods and may also have potential as a pharmaceutical product to combat obesity. The current study employed three experimental approaches to study the biology and chemistry of konjac, namely (1) glasshouse experiments to study the morphogenesis, growth and productivity of konjac plants, (2) a histological and immunocytochemical investigation of the localisation and developmental regulation of the deposition and metabolism o
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28

Omar, Maizatul Hasyima. "Analysis of phytochemical in a Malaysian medicinal plant and the bioavailability of dietary hydroxycinnamates." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4439/.

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The first study was looking into the phytochemical analysis of herbal medicinal plant from Malaysia. Phenolic compounds in an aqueous infusion from leaves of Ficus deltoidea (Moraceae), a well-known herbal tea in Malaysia, were analysed by HPLC coupled to photodiode-array and fluorescence detectors and an electrospray ionization tandem mass spectrometer. Following chromatography of extracts on a reverse phase C12 column 25 flavonoids were characterized and/or tentatively identified, with the main constituents being flavan-3-ol monomers, proanthocyanidins and C-linked flavone glycosides. The pr
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29

徐永欣 and Wing-yan Pamela Tsui. "Phytochemical investigation of plants used in traditional medicine in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31213704.

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The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,1995-1997<br>published_or_final_version<br>Chemistry<br>Master<br>Master of Philosophy
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30

Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat
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31

Wijeweera, Priyantha. "Phytochemical basis for the anxiolytic activity of the ayurvedic medicinal plant Centella asiatica (L) Urb (gotukola)." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26349.

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Gotukola (Centella asiatica L. Urban) (Apiaceae), its extracts and the pure compound asiaticoside were studied for anxiolytic activity in thirteen standardized rat trials. High performance liquid chromatography (HPLC) was used to conduct the phytochemical analysis. Among different models tested, the most promising positive response for anxiolytic activity was observed in the elevated plus maze test conducted with: (a) whole plant materials, (b) ethyl acetate and methanol fractions and (c) asiaticoside. The results show for the first time that asiaticoside and triterpene enriched fractions of g
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Alfaro, Inocente Edna Ariel. "Insecticidal and antifeedant activities of Malagasy medicinal plant (Cinnamosma sp.) extracts and drimane-type sesquiterpenes against Aedes aegypti mosquitoes." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586449408494604.

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33

Naman, Charles Benjamin. "Phytochemical Investigation of the Medicinal Plant Taxodium distichum and Library Screening of Thalictrum Alkaloids for New Antileishmanial Drug Leads." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429283826.

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34

Nguyen, Phuc Dam. "Etude phytochimique de plantes de la médecine traditionnelle du Vietnam et du Laos. Evaluation biologique dans le domaine de la santé." Thesis, Reims, 2015. http://www.theses.fr/2015REIMP204/document.

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L’objectif de ce travail est de contribuer à l'amélioration des connaissances phytochimiques et biologiques des plantes medicinales, afin d’en valoriser et d’en promouvoir l'usage en médicine traditionnelle au Vietnam. Dans ce travail de thèse, nous avons mené une étude phytochimique sur trois espèces végétales: Cleome chelidonii (Cleomaceae), Dolichandrone spathacea (Bignoniaceae) et Flacourtia rukam (Salicaceae). 90 composés ont été isolés et leurs structures ont été déterminées à l’aide des techniques spectroscopiques de RMN 1D et 2D, par la spectrométrie de masse ESI-MS, des données spectr
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35

Santos, Dayane Graziella Pereira de Oliveira dos 1988. "Produção de biomassa e teor de cumarina em folhas de guaco (Mikania laevigata Sch. Bip. ex Baker) em diferentes idades da planta /." Botucatu, 2016. http://hdl.handle.net/11449/138871.

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Orientador: Lin Chau Ming<br>Banca: Alexandra Christine Helena F. Sawaya<br>Banca: Marcos Roberto Furlan<br>Resumo: A espécie Mikania laevigata Sch. Bip. ex Baker, popularmente conhecida como guaco, pertence à família Asteraceae, é originária da região sul do Brasil e está entre as plantas medicinais adotadas pelo Sistema Único de Saúde do Brasil. M. laevigata é uma opção agrícola promissora no cultivo das medicinais, estando acessível ao pequeno produtor, tendo em vista a crescente demanda do mercado consumidor brasileiro por fitoterápicos. Uma vez que as plantas medicinais são classificadas
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Silva, Paulo Roberto Arbex [UNESP]. "Caracterização da composição química dos óleos essenciais de Lychnophora pinaster Mart. em função da sazonalidade." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/93527.

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Made available in DSpace on 2014-06-11T19:26:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-25Bitstream added on 2014-06-13T18:54:57Z : No. of bitstreams: 1 silva_pss_me_botfca.pdf: 1572244 bytes, checksum: cb40193cc7c83afdae5bc11bdedce824 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Avaliou-se a influência da sazonalidade no rendimento e composição química dos óleos essenciais de Lychnophora pinaster. O material vegetal foi coletado em Carrancas e Ingaí, Minas Gerais, no verão, outono, inverno e primavera de 2012. Foram utilizadas três populações n
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Silva, Paulo Sérgio Siberti da 1988. "Caracterização da composição química dos óleos essenciais de Lychnophora pinaster Mart. em função da sazonalidade /." Botucatu, 2013. http://hdl.handle.net/11449/93527.

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Orientador: Marcia Ortiz Mayo Marques<br>Banca: Elizabeth Orika Ono<br>Banca: Paulo Roberto Hrihorowitsch Moreno<br>Resumo: Avaliou-se a influência da sazonalidade no rendimento e composição química dos óleos essenciais de Lychnophora pinaster. O material vegetal foi coletado em Carrancas e Ingaí, Minas Gerais, no verão, outono, inverno e primavera de 2012. Foram utilizadas três populações nativas, denominadas Serra Branca, Serra do Salto (provenientes de Carrancas) e Serra da Arnica (Ingaí). Foram amostrados 25 acessos por população e os óleos essenciais das folhas extraídos por hidrodestilaç
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38

Viscardi, Ariel. "Avaliação da atividade antiproliferativa de extratos hidroalcoólicos de plantas em linhagens celulares humanas de câncer de mama, fígado e próstata." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-29082018-140818/.

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O câncer é uma das doenças que mais acometem a população no mundo. Dessa forma, estudar suas terapêuticas é importante para o entendimento dos mecanismos e alvos biológicos por detrás da doença. Apesar dos tratamentos convencionais apresentarem uma boa eficácia, eles também provocam respostas indesejadas, como danos moleculares, resistência de células neoplásicas e efeitos colaterais fortes, colaborando para uma maior taxa de reincidência de neoplasias e mortalidade de pacientes. Sendo assim, a busca por alternativas é um importante desafio da Ciência Moderna para aprimorar e/ou substituir ess
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Miller, Erin Suzanne. "Increasing Expression of Hepatitis B Surface Antigen in Maize through Breeding." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1359.

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The hepatitis B virus (HBV) is a common virus, with two billion people infected worldwide. It causes approximately 600,000 deaths each year, despite the availability of an effective vaccine since 1982. Maize as a platform for oral vaccination can supply a heat stable vaccine, which does not require syringes or trained personnel to administer. The Hepatitis B Surface antigen was transformed into maize and this seed was used to evaluate expression levels through the breeding process. The transgene was transferred into two elite maize inbreds by backcrossing. Highest expressing ears were selected
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40

Gianella-Borradori, Matteo Luca. "The identification & optimisation of endogenous signalling pathway modulators." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:4c87de5d-24a7-4998-8edb-917c3922aae1.

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<strong>Chapter 1</strong> Provides an overview of drug discovery with particular emphasis on library selection and hit identification methods using virtual based approaches. <strong>Chapter 2</strong> Gives an outline of the bone morphogenetic protein (BMP) signalling pathway and literature BMP pathway modulators. The association between the regulation of BMP pathway and cardiomyogenesis is also described. <strong>Chapter 3</strong> Describes the use of ligand based virtual screening to discover small molecule activators of the BMP signalling pathway. A robust cell based BMP responsive gene a
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Putter, Phillipus Johannes. "The development of functional hyaluronan hydrogels for neural tissue engineering." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:cd043ef4-a7bd-44f4-a9bf-4055e3d5ac13.

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Tissue engineers – in order to develop therapies for the treatment of complex neurological injuries and diseases – attempt to recreate elaborate developmental mechanisms in vitro. Neuronal precursor cells are excellent candidates for the study of developmental operations such as cell adhesion, differentiation, and axonal pathfinding. Hyaluronan (HA) is a common polysaccharide that is found extensively throughout the neuronal extracellular matrix (ECM), and can be functionalised and crosslinked to form stable hydrogels that support growing neuronal cells. Hyaluronan hydrogels can be modified ch
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42

Oyedeji, Opeoluwa Oyehan. "Chemical prospecting of medicinal plants for drug discovery." Thesis, 2010. http://hdl.handle.net/10413/8082.

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African traditional medicine relies largely on the abundant African flora estimated at several tens of thousands of species. These plants, like other living organisms, produce natural products which are organic molecules exhibiting a remarkable wide range of chemical diversity and a multiplicity of biological properties. Over the past 20 years, interest in drugs of plants origin has been reviving and growing steadily. Among the broad spectrum of natural products that are showing promise as possible leads to useful therapeutic agents are the terpenoids. In the present study, selected African me
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Welch, Cara Renae. "Chemistry and pharmacology of Kinkéliba (Combretum micranthum), a west African medicinal plant." 2010. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052288.

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Langlois, Angela. "The chemical investigation of four medicinal plants." Thesis, 2000. http://hdl.handle.net/10413/4625.

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This thesis describes a phytochemical investigation of four medicinal plants, namely, Agave attenuata (Agavaceae), Balanites maughamii (Balanitaceae), Astrotrichilia parvifolia (Meliaceae) and Combretum fragrans (Combretaceae). Investigations of A. attenuata and B. maughamii were undertaken as biological studies have shown that these plants possess anti-bilharzial properties. Schistosomiasis is an important public health issue in South Africa and attempts to deal with infected rural communities have forced scientists to focus their attention on snail control using plant molluscicides. A. atten
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45

"The ethnobotany and chemistry of South African traditional tonic plants." Thesis, 2012. http://hdl.handle.net/10210/8094.

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Ph.D. (Botany)<br>The most well-known tonic plants in South Africa have been used traditionally for the treatment of a great variety of ailments but aspects of their ethnobotany and chemistry remain poorly studied. Possible relationships between their ethnobotany and pharmacology are mostly speculative. In this study, literature reviews of the ethnobotany of these plants were combined with phytochemical screening studies and bitterness taste testing results in order to establish constituent patterns which may contribute to a scientific rationale for the claimed tonic (stimulating) properties o
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Steenkamp, P. A. "Chemical analysis of medicinal and poisonous plants of forensic importance in South Africa." Thesis, 2005. http://hdl.handle.net/10210/425.

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The Forensic Chemistry Laboratory of Johannesburg (FCL JHB) is tasked with the chemical analysis of a variety of samples to assist in determining the cause of death where unnatural cause is suspected. Some of the samples submitted to the laboratory have a herbal or muti connotation, but a large portion of these cases turn out to have no herbal components present as only pharmaceutical or agricultural products are detected in these samples. This study combined, for the first time, forensic investigation, chemistry and botany to create a unique platform needed for the identification of poisonous
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Page, Bronwen Ann. "Extractives of three southern African medicinal plants." Thesis, 1998. http://hdl.handle.net/10413/4417.

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In this investigation the chemistry of three southern African plants used for medicinal purposes was investigated. The plants were Dioscorea dregeana, Avonia rhodesica and Equisetum ramossisimum. Extracts of all three of these plants have been found to be active on the central nervous system. The structures of the compounds isolated were determined by using 1H and 13C n.m.r., i.f., UV-VIS, - mass spectroscopy and chemical methods. D. dregeana yielded two alkaloids and three aromatic compounds. A. rhodesica contained a large amount of wax which was analysed by GC-MS and its distribution and phy
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Komolafe, Naomi Tope. "Antimicrobial activity of some medicinal plant extracts against bacteria causing diarrhoea." Diss., 2014. http://hdl.handle.net/10500/18907.

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Infectious diarrhoea is the second largest single cause of mortality in children under the age of five globally. Bacteria are responsible for most diarrhoeal episodes especially in developing countries, and progressive increase in antimicrobial resistance has given rise to the need to investigate other sources of therapy such as medicinal plants. Ten plant extracts were analysed for their antimicrobial activities using the agar well diffusion and broth microdilution method. Their phytochemical contents were screened, and their effect on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) was used to assess
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Sewram, Vikash. "A chemical investigation of a KwaZulu-Natal medicinal plant, Momordica foetida Schum. & Sond." Thesis, 1994. http://hdl.handle.net/10413/5075.

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Momordica foetida Schum. & Sond. (Cucurbitaceae), locally known as iNtshungu, is widely used by the Zulu people of Natal-KwaZulu for the treatment of a variety of ailments. The dried leaves leaves and stems of this plant was subjected to soxhlet extraction by refluxing with hexane, chloroform and methanol successively. Thin layer chromatography of the chloroform extract of the leaves revealed a multiplicity of compounds. The chloroform extract was further partitioned with sodium hydroxide resulting in an organic and aqueous phase. The organic phase, containing extract A, afforded two compounds
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Steyn, Trevor. "The chemical constituents of Ehretia rigida, Apodytes dimidiata and Ocotea kenyensis." Thesis, 1998. http://hdl.handle.net/10413/4400.

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Three species have been investigated in this project: Iso-ocobullenone (p 23) and its probable precursor (p 27) have been isolated from the leaves and bark of Ocotea kenyensis. This is only the second time that these compounds have been isolated and the first time from this species. The isolation of these two compounds in the leaves establishes a commercially important chemical link with the bark. The bark of the closely related Ocotea bullata is the most sought after source of "muthi" in the Kwa-Zulu Natal region and it is becoming a very scarce commodity. The leaves of Ocotea kenyensis have
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