Relevant bibliographies by topics / Plasma HbA1C

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Plasma HbA1C'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Plasma HbA1C"

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Kapil, Deb Lahiri, Kundu Arunava, Baruah Mriganka, and Ghosh Joya. "A STUDY ON CORRELATIONS OF FASTING PLASMA GLUCOSE WITH AQUEOUS HUMOR GLUCOSE AND HBA1C IN CATARACT PATIENTS." International Journal of Basic and Applied Physiology 8, no. 1 (2019): 47–51. https://doi.org/10.5281/zenodo.4483322.

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<strong>Background &amp; objectives</strong>: Indian guideline approved the cataract surgery with fasting plasma glucose of &lt;140 mg/dl and random plasma glucose of less than 180mg/dl but no data on the relationship of fasting plasma glucose with aqueous glucose level and HbA1c in cataract patients was available in India. Hence our study will try to explore the relationship of fasting plasma glucose with aqueous glucose level and HbA1c in cataract patients. <strong>Methods</strong>: Thirty-six (Group A) &amp; 40 (Group B) cataract patients with fasting plasma glucose in between 100 &ndash; 1
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Bhatti, Saeed Akram, Abdul Haseeb Khan, and Naeem Yaqoob. "GLYCATED HEMOGLOBIN (HbA1c)." Professional Medical Journal 22, no. 02 (2015): 208–14. http://dx.doi.org/10.29309/tpmj/2015.22.02.1376.

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HbA1c gives an integrated index of glycemia over the entire 120 days lifespan of red blood cells. Therefore, measuring HbA1c would be appropriate in diagnosing adisease characterized by chronic hyperglycemia and a gradual progression to complications.Objectives: our primary objective was to evaluate the use of HbA1c as screening test forundiagnosed diabetes (WHO criteria of Fasting plasma glucose (FPG) of ≥ 7mmol/l (126mg/dl))in healthy asymptomatic individuals in Pakistani population. Study Design and Methodology:A cross sectional population survey was carried on asymptomatic, healthy individ
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Hossain, Tanjina, Zafar Ahmed Latif, and Abdullah Al-mamun Sarkar. "Relationship of HbA1c with Fasting and Plasma Glucose 2 Hours after Oral Glucose Load in Non Diabetic and Newly Diagnosed Pre Diabetic and Diabetic Patients." BIRDEM Medical Journal 2, no. 2 (2012): 81–83. http://dx.doi.org/10.3329/birdem.v2i2.12307.

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Objectives: This study was conducted to assess the relationship of Fasting Plasma Glucose and Plasma Glucose 2 hours after 75 gram glucose load with HbA1c in subjects who were not detected before as diabetic, pre diabetic or non diabetic. Methods: Total eight hundred and seventy eight subjects of both sexes coming to do for an Oral Glucose Tolerance Test (OGTT) were included in the study. Fasting and plasma glucose 2 hours after 75 gram glucose load were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography (HPLC) method. Results: According to OGTT among t
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Kumar, Binay, Nidhi Prasad, and Ravi Shekhar. "Post prandial glucose can be a substitute for HbA1c in low resource setting: answering the diagnostic dilemma." International Journal of Research in Medical Sciences 9, no. 2 (2021): 645. http://dx.doi.org/10.18203/2320-6012.ijrms20210460.

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Achieving a strict glycaemic control is the key factor in diabetes management and associated complications. Although A1C is the best indicator of overall glycaemic control during the previous 2-3 months and remains the gold standard for assessing glycaemic control in patients with diabetes. But in low resource setting areas where HbA1c is a costlier affair, postprandial plasma glucose estimation can be a good alternative in estimating glycaemic control. By analyzing the results from many previous papers on glycaemic profiles, we conclude that contribution of postprandial plasma glucose was rel
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Md., Abdul Malek. "Correlation of Glycated Hemoglobin with Plasma Glucose in Type 2 Diabetic Patients." International Journal of Medical and Pharmaceutical Research 4, no. 1 (2023): 171–76. https://doi.org/10.5281/zenodo.7639634.

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<strong>Background: </strong>Diabetes is a common disease in both developed and developing countries. Increasing prevalence of the disease sets the goal to aim for control of the disease process which is aimed mainly as therapy. Monitoring tool for the complications of this common disease is Glycated Hemoglobin (HbA1C). <strong>Objective: </strong>In the present retrospective study HbA1C level is correlated with both fasting and post meal plasma glucose level in type-2 diabetes mellitus patients. <strong>Methods: </strong>The retrospective study was done in Department of Biochemistry &amp; Mol
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Batista, Raíssa A. B., Flávia M. S. de Branco, Rafaela Nehme, Erick P. de Oliveira, and Geórgia das G. Pena. "Association between Plasma Omega-3 and Handgrip Strength According to Glycohemoglobin Levels in Older Adults: Results from NHANES 2011–2012." Nutrients 14, no. 19 (2022): 4060. http://dx.doi.org/10.3390/nu14194060.

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Background: Low muscle strength is a predictor of mortality in older adults. Although the evidence concerning hyperglycemia is limited, evidence shows that omega-3 (ω-3) intake may be positively associated with muscle strength. However, the association between plasma ω-3 and muscle strength in older adults according to glycohemoglobin (HbA1c) levels has not yet been investigated. Objective: To evaluate whether plasma ω-3 levels are associated with handgrip strength in individuals over 50 years according to HbA1c levels. Methods: This cross-sectional study included 950 older adults (50–85 years
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Inada, Shinya, and Masafumi Koga. "Alcohol consumption reduces HbA1c and glycated albumin concentrations but not 1,5-anhydroglucitol." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 54, no. 6 (2016): 631–35. http://dx.doi.org/10.1177/0004563216675646.

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Background The effect of alcohol consumption on glycaemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycaemic control indicators in non-diabetic men. Methods The study enrolled 300 non-diabetic men who received a complete medical checkup (age: 52.8 ± 6.5 years, body mass index: 24.4 ± 2.8 kg/m2). The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) concentrations of the groups were compared. Results As t
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Ansari, Shiba, Jayeeta Bhadra, Ashok Kumar Ahirwar, and Jasmeen Gupta. "Correlation analysis of HbA1c versus random, fasting, and postprandial glucose levels as predictors of glycemic control in type 2 diabetes patients." Asian Journal of Medical Sciences 14, no. 4 (2023): 37–43. https://doi.org/10.71152/ajms.v14i4.3740.

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Background: Glycated Hemoglobin (HbA1c) is used for assessing glycemic control over the past 8–12 weeks. This is critical for determining the efficacy of diabetes treatment and predicting the progression of microvascular complications. However, in health-care situations where tests for HbA1c are either unavailable or unfeasible for any reason, clinicians rely only on plasma glucose values for assessing the glycemic control of the patient. Aims and Objectives: The purpose of this study was to determine the relationship between HbA1c and fasting, postprandial, and random plasma glucose levels. M
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Ansari, Shiba, Jayeeta Bhadra, Ashok Kumar Ahirwar, and Jasmeen Gupta. "Correlation analysis of HbA1c versus random, fasting, and postprandial glucose levels as predictors of glycemic control in type 2 diabetes patients." Asian Journal of Medical Sciences 14, no. 4 (2023): 37–43. http://dx.doi.org/10.3126/ajms.v14i4.53072.

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Background: Glycated Hemoglobin (HbA1c) is used for assessing glycemic control over the past 8–12 weeks. This is critical for determining the efficacy of diabetes treatment and predicting the progression of microvascular complications. However, in health-care situations where tests for HbA1c are either unavailable or unfeasible for any reason, clinicians rely only on plasma glucose values for assessing the glycemic control of the patient. Aims and Objectives: The purpose of this study was to determine the relationship between HbA1c and fasting, postprandial, and random plasma glucose levels. M
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TUCKER, MIRIAM E. "Formula Links HbA1c to Average Plasma Glucose." Family Practice News 37, no. 21 (2007): 17. http://dx.doi.org/10.1016/s0300-7073(07)71301-4.

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Dissertations / Theses on the topic "Plasma HbA1C"

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Shao, Jing. "Glycated haemoglobin A1c compared to fasting plasma glucose and oral glucose tolerance testing for diagnosing type 2 diabetes and pre-diabetes : a meta-analysis." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/43240.

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BACKGROUND In 2010, glycated haemoglobin A1c (HbA1c) was officially recommended as a screening tool to diagnose type 2 diabetes mellitus (T2DM) and pre-diabetes, with cut-off points 6.5% and 5.7% to 6.4% respectively. The implications of using the HbA1c criterion, compared to the general diagnostic criteria: fasting glucose test (FPG) and oral glucose tolerance test (OGTT), is however still being debated. OBJECTIVES The objectives of this study were to evaluate and compare the pooled prevalence of type 2 diabetes mellitus (T2DM) and pre-diabetes, as measured by the Haemoglobin A1c (HbA1c) t
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Heath, Ashleigh E. "Comparison of Screening Methods for Pre-diabetes and Type 2 Diabetes Mellitus by Race/Ethnicity and Gender." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/iph_theses/202.

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INTRODUCTION/OBJECTIVES: Current screening guidelines for pre-diabetes and type 2 diabetes mellitus note that there are discrepancies in diagnosing the disease using the fasting plasma glucose test, oral glucose tolerance test, and HbA1c in high-risk populations. The objective of this study is to compare the effectiveness of screening methods for type 2 diabetes mellitus (T2DM) and pre-diabetes by race/ethnicity and gender. METHODS: Secondary analyses of the National Health and Nutrition Examination Survey (NHANES, 2005-2008) were performed using SPSS 19.0. Screening outcomes were assessed and
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Soulimane, Soraya. "Les caractéristiques de l’HbA1c, nouveau critère diagnostique du diabète." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T020.

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La prévalence du diabète ne cesse d’augmenter et la détection de sujets à risque de développer cette maladie reste une préoccupation importante afin qu’un programme de prévention leur soit proposé. Le dosage de l’HbA1c est utilisé pour l’évaluation de l’efficacité du traitement pris par les diabétiques. Il n’était pas utilisé pour le diagnostic des dysglycémies car les méthodes de ce dosage n’étaient pas standardisées. Actuellement l’IFCC (International Federation of Clinical Chemistry) propose une nouvelle méthode de référence pour cette mesure, et l’OMS (Organisation Mondiale de la Santé) a
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Elhatab, Nesrin M. "The community pharmacist's role enhancing medicines management for type II diabetes in Tripoli, Libya : a randomised controlled trial in community pharmacy to investigate knowledge and practice in relation to type II diabetes and glycaemic control." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/15903.

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Aim/Objectives: There were two aims; improving type II diabetes glycaemic control; and enhancing the role of community pharmacists by engaging them in type II diabetes medicine management. Methods: This quantitative study collected data from both community pharmacists and patients. In a premises survey, 426 self-administered questionnaires were distributed to community pharmacies. In a knowledge survey, 125 questionnaires were distributed to community pharmacists. In a clinical trial, 40 community pharmacies were randomly assigned to be control (18) and intervention (22) premises. Each pharmac
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Elhatab, Nesrin M. "The Community Pharmacists’ Role Enhancing Medicines Management for Type II Diabetes in Tripoli, Libya. A Randomised Controlled Trial in Community Pharmacy to Investigate Knowledge and Practice in Relation To Type II Diabetes and Glycaemic Control." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/15903.

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Aim/Objectives: There were two aims; improving type II diabetes glycaemic control; and enhancing the role of community pharmacists by engaging them in type II diabetes medicine management. Methods: This quantitative study collected data from both community pharmacists and patients. In a premises survey, 426 self-administered questionnaires were distributed to community pharmacies. In a knowledge survey, 125 questionnaires were distributed to community pharmacists. In a clinical trial, 40 community pharmacies were randomly assigned to be control (18) and intervention (22) premises. Each pha
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Eriksson, Louise. "Validation of a colorimetric method for determination of fructosamine in plasma usingMindray BS-380." Thesis, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349084.

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HbA1c and glucose are the most widely used indicators for glucose control, but they havesome disadvantages. Improving the diagnosis of diabetes is always ongoing, other markersare needed as a complement when standard measurements are not sufficient. One alternativeis analysis of fructosamine, which is commercially available and inexpensive.The main aim with this study was to validate a colorimetric method for analyzingfructosamine including investigation of precision, linearity and stability. Fructosamine valueswas compared with HbA1c values with and without genetic variations in the hemoglobi
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Chou, Huan-Ting, and 周煥庭. "On-Chip HbA1c Detection Utilizing a Compact Surface Plasmon Grating Sensor Integrated on a Microfluidic System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/45228640158938543186.

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碩士<br>國立清華大學<br>光電工程研究所<br>103<br>Surface plasmon utilized for biosensing applications has been demonstrated with high sensitivity. There are many types of surface plasmon biosensors today. In this research, we focus on a grating-based surface plasmon biosensor. The grating-based SP biosensor detects the biomolecule through interrogating the shift of the reflection spectrum. According to the simulation result by Finite Difference Time Domain (FTDT) method, we found that the bandwidth is generally related to the profile of the grating. In addition, we integrate microfluidic systems into the SPR
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Book chapters on the topic "Plasma HbA1C"

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Kilpatrick, Eric S. "Uncertainty Around the Estimate of Average Plasma Glucose from HbA1c." In HbA1cin Diabetes. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9781444320343.ch30.

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Ecesoy, Volkan, and Hasan Arici. "Evaluation of Diabetes and Biochemical Markers." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.4.

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The evaluation of diabetes through biochemical markers involves a comprehensive approach to assess metabolic disturbances and monitor disease progression. Key biochemical markers include blood glucose levels, glycosylated hemoglobin (HbA1c), and insulin sensitivity indices such as the homeostatic model assessment of insulin resistance (HOMA-IR). Blood glucose levels are fundamental for diagnosing and managing diabetes, with fasting plasma glucose and oral glucose tolerance tests providing insights into glycemic control. HbA1c, reflecting average blood glucose levels over the preceding 2-3 mont
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Arici, Hasan, and Volkan Ecesoy. "Role of Oral Glucose Tolerance Tests in Diabetes Mellitus." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.6.

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The oral glucose tolerance test (OGTT) serves as a pivotal diagnostic tool and a measure of glucose metabolism dynamics in diabetes mellitus (DM). In clinical settings, the OGTT involves administering a standardized glucose solution to the patient after an overnight fast, followed by periodic measurements of blood glucose levels over several hours. This test is instrumental in diagnosing impaired glucose tolerance (IGT) and diabetes mellitus by evaluating how effectively the body processes glucose. Diagnostic thresholds are established based on plasma glucose levels measured at specific time p
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Adegoke Azeez, Taoreed. "Present State and Perspectives of Type 2 Diabetes Management." In Type 2 Diabetes in 2024 - From Early Suspicion to Effective Management. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1002447.

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Diabetes mellitus is a common metabolic disorder characterised by chronic hyperglycaemia that results from a defect in insulin secretion, action, or both. There are different types of diabetes mellitus, but type 2 diabetes mellitus is the most common type globally. Type 2 diabetes mellitus results from a complex interaction between predisposing genes and unhealthy lifestyle choices. The risk factors for type 2 diabetes include obesity, prediabetes, sedentary lifestyle, unhealthy diets, and hypertension. Poorly controlled diabetes causes microvascular and macrovascular complications. The goals
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Cui, Ran, Elena Daskalaki, Md Zakir Hossain, Artem Lenskiy, Christopher J. Nolan, and Hanna Suominen. "A Significance Assessment of Diabetes Diagnostic Biomarkers Using Machine Learning." In Studies in Health Technology and Informatics. IOS Press, 2021. http://dx.doi.org/10.3233/shti210657.

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Diabetes can be diagnosed by either Fasting Plasma Glucose or Hemoglobin A1c. The aim of our study was to explore the differences between the two criteria through the development of a machine learning based diabetes diagnostic algorithm and analysing the predictive contribution of each input biomarker. Our study concludes that fasting insulin is predictive of diabetes defined by FPG, but not by HbA1c. Besides, 28 other fasting blood biomarkers were not significant predictors of diabetes.
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Soboleva, Alena, Natalia Vashurina, and Andrej Frolov. "Individual Glycation Sites as Biomarkers of Type 2 Diabetes Mellitus." In Type 2 Diabetes [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95532.

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Type 2 diabetes mellitus (T2DM) is a widely spread metabolic disease, the initial stages of which are asymptomatic and have no clinically recognizable manifestation. At the molecular level, T2DM is manifested with essential non-enzymatic structural changes of intra- and extracellular proteins, mostly represented with oxidation and glycation of multiple residues. Protein glycation is one of the most universal markers of T2DM, and is recognized as an indirect, but adequate indicator of plasma glucose levels over prolonged periods of time. Unfortunately, glycated hemoglobin (HbA1c) – the universa
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Nováková, Noemi, Martin Nezval, and Viktória Molnárová. "Pathophysiology-Oriented Treatment of Type 2 Diabetes: 10 Case Reports." In Type 2 Diabetes - From Diagnosis to Effective Management [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.1002857.

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The effects of pathophysiology-oriented treatment using metformin and/or insulin analogs and/or incretin GLP-1 receptor agonists and/or dapagliflozin and/or pioglitazone were individually evaluated in ten people with type 2 diabetes (T2D) at an urban diabetes center. Some of them had microangiopathy and/or neuropathy and/or nephropathy. The observation period ranged from 2 to 12 years. Treatment efficiency was estimated according to changes in HbA1c, body mass, insulin dose per day, blood pressure, lipoproteins, albuminuria, estimated glomerular filtration rate (eGFR), and general clinical con
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A. Adeghate, Ernest, Sahar Mohsin, Ahmed Bin Amar, et al. "Diabetes-Induced Cardiomyopathy: Updates in Epidemiology, Prevention, and Management." In Etiology, Prevention and Management of Cardiomyopathy [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1006679.

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Diabetes mellitus (DM) is a condition of abnormal carbohydrate metabolism, leading to persistent hyperglycemia. It is defined as a fasting blood glucose over 7.0 mmol/L, a 2-hour plasma post-meal of 11.1 mmol/L, or HbA1C values over 6.5% (48 mmol/L). DM affects almost 600 million people globally with an annual cost of around three trillion US dollars. These data indicate that DM is a global health burden that warrants attention. Complications of DM include nephropathy, retinopathy, neuropathy, and cardiomyopathy. DM-induced hyperglycemia causes oxidative stress, inflammation, endothelial and m
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"Association of plasma free fatty acids and C-reactive protein levels as marker of inflammation in patients with Type 2 diabetes." In Book of Abstracts - RAD 2025 Conference. RAD Centre, Niš, Serbia, 2025. https://doi.org/10.21175/rad.abstr.book.2025.3.1.

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Type 2 diabetes (T2D), as a common type of diabetes mellitus, is influenced by various factors such as genetics and environment. One of the most important risk factors for the development of T2D is insulin resistance (IR), the underlying mechanisms of which include impaired free fatty acid (FFA) metabolism and inflammation. Chronically elevated levels of plasma free fatty acids appear to disrupt normal glucose homeostasis, while increased levels of a key inflammatory marker, C-reactive protein (CRP), lead to endothelial dysfunction and other T2D complications. The aim of this study was to exam
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Chlup, Rudolf, Richard Kaňa, Lada Hanáčková, Hana Zálešáková, and Blanka Doubravová. "Pathophysiologic Approach to Type 2 Diabetes Management: One Centre Experience 1980–2020." In Type 2 Diabetes [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96237.

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This overview summarizes the evolution of pathophysiologic treatment of diabetes type 2 (T2D) in the period of the last 40 years. Randomized Controlled Trials (RCT) and Real World Evidence (RWE) studies resulted in recent Statements of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) in the year 2020. Case reports and studies of a single-centre in Czech Republic are reported. The authors demonstrate the impact of (1) multiple doses of rapid insulin, (2) multiple doses of rapid or ultrarapid insulin analogs (3) continuous subcutaneous insulin
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Conference papers on the topic "Plasma HbA1C"

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Plywaczewski, Robert, Barbara Kazanecka, Dorota Gorecka, and Pawel Sliwinski. "Plasma Haemoglobin A1c (HbA1c) Concentration And Cardiovascular Complications In Obstructive Sleep Apnoea (OSA) Patients With And Without Diabetes." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3696.

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Sandbjerg Hansen, M., and B. Milner Jørgensen. "FUNCTIONAL CHANGES IN ANTITHROMBIN III IN INSULIN-DEPENDENT DIABETES MELLITUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643104.

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The thrombin neutralizing activity of Antithrombin III (AT) was measured in a group of patients with insulin-dependent diabetes mellitus. All patients evaluated had diabetes of several years duration. Their blood glucose control was unsatisfactory as evidenced by relative concentrations of glycated hemoglobin (HbA1c) of 9.6-14.0% determined by polyacrylamide gel electrophoresis. The plasma AT-activity was estimated as thrombin neutralizing activity using the chromogenic substrate Th-1.The group of diabetic patients had a higher AT-activity than a reference group, but normal AT-concentrations b
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"ASSOCIATION OF FREE FATTY ACID CONCENTRATIONS WITH GLUCOSE LEVELS IN BOSNIAN SUBJECTS." In RAD Conference. RAD Centre, Niš, Serbia, 2023. http://dx.doi.org/10.21175/radproc.2023.09.

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Although there is considerable evidence suggesting a strong association of glucose, glycated hemoglobin and fatty acid levels with Type 2 diabetes mellitus (T2D), a limited number of studies have examined the association of individual fatty acids with disease progression. Acutely elevated plasma fatty acids stimulate insulin secretion while chronically elevated plasma fatty acids alter and disrupt insulin secretion. Furthermore, free fatty acids (FFA) are known to interfere with normal glucose homeostasis and affect pancreatic β-cell dysfunction. The study included 24 patients with newly diagn
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"FATTY ACID ENZYME ACTIVITIES AND RISK OF DIABETES MELLITUS." In RAD Conference. RAD Centre, Niš, Serbia, 2024. https://doi.org/10.21175/radproc.2024.14.

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The prevalence of diabetes mellitus, especially type 2 diabetes (T2D), is high worldwide and there is an ongoing challenge to find potential biomarkers that could predict the onset of diabetes and provide insight into possible mechanisms for its development. Previously published data have shown that the composition and concentrations of free fatty acids (FFA) in plasma/serum are associated with the occurrence and risk of developing diabetes. Recent evidence suggests that the composition and content of free fatty acids are influenced by many factors, such as age, sex, ethnicity, dietary habits
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Boschetti, C., A. Vicari, E. Cofrancesco, et al. "HEPARIN-RELEASED PLATELET FACTOR 4 (HR-PF4) IN DIABETIC MICR0VAS-CULAR DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643498.

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When heparin is injected i.v. as a bolus, PF4 but not (β-throm boglobulin ((βTG) is released immediately. HR-PF4 is not liberated from platelets but from the endothelial cells of vessels which serve as storage sites. The role of platelet activation in diabetic microvascular disease is still controversial, however there is experimental evidence of vascular injury and hemostatic activation preceding the appearance of microvascular disease. The contradictory results so far obtained in man may be partly attributed to the heterogeneity of the diabetic patients studied. We studied 20 insulin-depende
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