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Journal articles on the topic 'Plasma lyophilisé'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Cauet, A., S. Ausset, and A. Sailliol. "Plasma lyophilisé : données de deux années d’hémovigilance active." Annales Françaises d'Anesthésie et de Réanimation 33 (September 2014): A125—A126. http://dx.doi.org/10.1016/j.annfar.2014.07.208.

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Christophe, M., C. Vauthier, C. Civadier, A. Sailliol, and V. Foissaud. "Évaluation des qualités hémostatiques du plasma lyophilisé par mesure de la génération de thrombine." Transfusion Clinique et Biologique 20, no. 3 (2013): 331–32. http://dx.doi.org/10.1016/j.tracli.2013.03.143.

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Jost, Daniel. "Administration préhospitalière de plasma lyophilisé « PLYO » au cours d’un choc hémorragique post-traumatique : étude « PREHO-PLYO »." Transfusion Clinique et Biologique 25, no. 4 (2018): 303. http://dx.doi.org/10.1016/j.tracli.2018.08.090.

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Beaume, S., B. Prunet, J. Cotte, et al. "Utilisation du plasma lyophilisé (PLYO) en salle d’accueil des urgences vitales (SAUV) pour l’accueil des traumatisés graves." Annales Françaises d'Anesthésie et de Réanimation 33 (September 2014): A125. http://dx.doi.org/10.1016/j.annfar.2014.07.207.

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Nabil, GHEDADBA, HAMBABA Leila, C. ABERKANE M., Oueld-Mokhtar M., FERCHA Nassima, and BOUSSELSELA Houas. "Évaluation de l'activité hémostatique in vitro de l'extrait aqueux des feuilles de Marrubium vulgare L." Algerian Journal of Natural Products 2, no. 2 (2014): 64–74. https://doi.org/10.5281/zenodo.556745.

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L'objectif de cette étude est d’évaluer <em>in vitro</em> l’activité hémostatique des métabolites secondaires des feuilles de <em>Marrubium vulgare</em>. L’analyse qualitative de l’extrait aqueux (EAQ) par la chromatographie sur couche mince a révélé la présence de la quercétine, la rutine et le kaempférol. La quantification des phénols totaux par la méthode de Folin Ciocalteu et des flavonoïdes par la méthode AlCl<sub>3</sub> a donné des valeurs élevées avec l’EAQ : 175 ± 0,80 mg EAG/100g de MS, 23,86 ± 0,36 mg EQ/100g de MS. De plus, le dosage des tanins condensés par la méthode de la vanill

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ESNAULT, P., P. J. CUNGI, P. ROMANAT, et al. "Transfusion sanguine en opération extérieure. Expérience à l’hôpital médico-chirurgical de Kaboul." Médecine et Armées Vol. 41 No. 5, Volume 41, Numéro 5 (December 1, 2013): 441–45. http://dx.doi.org/10.17184/eac.6709.

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Objectifs. - La transfusion sanguine est un des éléments majeurs du soutien médico-chirurgical des militaires en opération extérieure. Les moyens français comportent : des concentrés de globules rouges (CGR), du plasma lyophilisé (PLYO), le sang total (ST) mais ni plaquettes, ni plasma frais congelé. La stratégie transfusionnelle française en opérations militaires extérieures suit l’évolution des savoirs et des moyens. Nous décrivons ici les caractéristiques de la transfusion sanguine à l’hôpital militaire de Kaboul. Matériels et méthodes. - Étude rétrospective des dossiers des patients transf

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Ginot, Jean. "Suggestion for an easy storage and fast opening freeze dried (lyophilised) Plasma pack." Hematology & Transfusion International Journal 12, no. 4 (2024): 97–98. https://doi.org/10.15406/htij.2024.12.00341.

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Hemorrhagic shock is an emergency situation. As plasma is highly indicated in hemorrhagic shock in addition to red cell concentrates and platelets concentrates, lyophilised plasma has been developed in order to skip time of thawing Fresh frozen plasma, and to be transported easily in prehospital. The aim of our suggestion is not to compare of lyophilised plasma vs fresh frozen plasma. Lyophilised plasma is stored in glass bottle. Plastics bags may be much easier to transport than glass bottle particularly in emergency ambulance. We suggest fast opening pack for plasma as multi-chambers bag. Fa

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8

Jennings, I., T. A. L. Woods, F. E. Preston, and S. Kitchen. "Local Calibration of International Normalised Ratio Improves between Laboratory Agreement: Results from the UK National External Quality Assessment Scheme." Thrombosis and Haemostasis 81, no. 01 (1999): 60–65. http://dx.doi.org/10.1055/s-0037-1614419.

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SummaryIn the present study we have performed local calibration of International Normalised Ratio (INR) measurement systems in a large series of laboratories. We assigned INRs to five lyophilised plasma calibrants, one prepared from normal plasma and four using plasma from war-farinised patients, using different International Reference Preparations for Thromboplastin. These five calibrants, and two lyophilised test plasmas were analysed by 349 centres using 60 different thromboplastin instrument combinations.Plasma calibrants were assigned INRs using the WHO reference thromboplastin RBT-90 or

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9

Roche, Céline, Stéphane Bouzard, Véronique Cellarier, Thomas Pouget, Benoît Clavier, and Anne Sailliol. "Formation des médecins et infirmiers à la transfusion en situation de crise – Expérience du centre de transfusion sanguine des armées dans la formation à la collecte et transfusion de sang total et de plasma lyophilisé en situation d’exception." Transfusion Clinique et Biologique 23, no. 4 (2016): 274–75. http://dx.doi.org/10.1016/j.tracli.2016.08.017.

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10

Langley, Katy, Andrew Chitolie, Ri Liesner, et al. "Discrepancies between ADAMTS13 activity assays in patients with thrombotic microangiopathies." Thrombosis and Haemostasis 109, no. 03 (2013): 488–96. http://dx.doi.org/10.1160/th12-08-0565.

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SummaryADAMTS13 activity assays are sometimes useful in confirming the clinical diagnosis or to distinguish different thrombotic microangiopathies (TMA). We investigated the commonly used clinical assays for ADAMTS13 activity. 159 samples from normal subjects or acquired TMA patients were studied in collagen binding (CBA), Fret and chromogenic peptide substrate assays. Frozen aliquots of pooled normal plasma gave similar values by CBA, Fret-VWF73 peptide, Fret-VWF86 and chromogenic VWF73 ELISA (chr-VWF73). Two lyophilised commercial calibrants gave lower ADAMTS13 activity by CBA than peptide s

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11

Schoenfeld, Helge, Axel Pruss, Mareike Keller, et al. "Lyophilised plasma: evaluation of clotting factor activity over 6 days after reconstitution for transfusion." Journal of Clinical Pathology 63, no. 8 (2010): 726–30. http://dx.doi.org/10.1136/jcp.2010.079293.

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AimsLittle is known about long-term stability of clotting factors in dissolved human lyophilised plasma. This study evaluated clotting factor and inhibitor activity in reconstituted lyophilised plasma after storage for up to 6 days at 4°C.MethodsFive samples from different lots of pooled lyophilised plasma (LyoPlas; German Red Cross Blood Transfusion Service West) were reconstituted. The activity of fibrinogen, factor II (FII), FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII, antithrombin, plasmin inhibitor, von Willebrand factor antigen, free protein S and protein C were determined immediately and

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12

Kitchen, S., I. Jennings, T. A. L. Woods, I. D. Walker, and F. E. Preston. "Two Recombinant Tissue Factor Reagents Compared to Conventional Thromboplastins for Determination of International Normalised Ratio: A Thirty-three-laboratory Collaborative Study." Thrombosis and Haemostasis 76, no. 03 (1996): 372–76. http://dx.doi.org/10.1055/s-0038-1650586.

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SummaryRecent advances in recombinant technology have led to the development of prothrombin time (PT) reagents containing recombinant tissue factor which has been lipidated to allow expression of procoagulant activity. In this study we have compared International Normalised Ratios (INRs) determined using two such reagents and conventional thromboplastins in widespread use in the UK.Lyophilised plasma samples from eight different warfarinised patients were distributed to 33 laboratories in the UK. Each participant determined prothrombin times on 20 local fresh normal plasmas (used to derive mea

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Gaffney, Patrick J., and M. Y. Wong. "Collaborative Study of a Proposed International Standard for Plasma Fibrinogen Measurement." Thrombosis and Haemostasis 68, no. 04 (1992): 428–32. http://dx.doi.org/10.1055/s-0038-1646291.

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SummaryThere is increased interest in the relationship between plasma fibrinogen levels and the incidence of coronary artery disease. The National Institute for Biological Standards and Control (UK) has completed a study to establish an International Standard for plasma fibrinogen. This study was conducted using a recommended assay procedure to measure the clottable material present in the proposed lyophilised Standard (coded 89/644). Twenty-two laboratories from nine countries took part in the study and analysis of the data allowed the calibration of 89/644 at 2.4 mg/ml clottable protein. Agr

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14

Egberg, Nils, Andreas Hillarp, Ole Ødegaard, et al. "INR calibration of Owren-type prothrombin time based on the relationship between PT% and INR utilizing normal plasma samples." Thrombosis and Haemostasis 91, no. 06 (2004): 1223–31. http://dx.doi.org/10.1160/th03-07-0456.

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SummaryProthrombin time (PT) is clinically important and is used to monitor oral anticoagulant therapy. To obtain PT results in international normalized ratio (INR), the current standardization procedure is complex and involves reference reagents.The PT of diluted plasma samples can be determined with a combined thromboplastin (the Owren-type procedure), but not necessarily with a plain thromboplastin (the Quick-type procedure). Owren-type PT procedures can therefore, as an alternative to the INR calibration, be calibrated with diluted normal plasma to give PT results in percent of normal PT a

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15

Goggs, Robert, Signe Cremer, and Marjory B. Brooks. "Evaluation of cytokine concentrations in a trehalose-stabilised lyophilised canine platelet product: a preliminary study." Veterinary Record Open 7, no. 1 (2020): e000366. http://dx.doi.org/10.1136/vetreco-2019-000366.

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BackgroundPlatelet transfusion is indicated for haemorrhage due to severe thrombocytopenia and for trauma associated coagulopathy. Febrile non-haemolytic transfusion reactions are a common complication of platelet transfusions in people and may be due to accumulated inflammatory cytokines. The present study aimed to determine the cytokine profile of a novel canine lyophilised platelet product following reconstitution, to assess the lyophilised platelets’ activation response to physiological platelet agonists and to compare the cytokine profiles of basal and stimulated canine lyophilised platel

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16

Stadler, Monika, Gerhard Gruber, Christoph Kannicht, et al. "Characterisation of the Novel, High Purity, Double Virus Inactivated Von Willebrand Factor and Factor VIII Concentrate Wilate®." Blood 106, no. 11 (2005): 4067. http://dx.doi.org/10.1182/blood.v106.11.4067.4067.

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Abstract Purpose: This study summarizes the characteristics and virus safety profile of Wilate®, a new human plasma-derived, high purity, double virus inactivated VWF/FVIII concentrate. The manufacturing process comprises two chromatographic steps, ensuring high purity and preserving the integrity and functionality of the VWF/FVIII complex. The optimised solvent/detergent treatment (S/D) and terminal dry-heat treatment (PermaHeat) of the lyophilised product provide two effective and robust virus inactivation steps for enveloped (EV) and one step for non-enveloped viruses (NEV). Methods: Functi

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17

Kannicht, Christoph, Monika Stadler, Andrea Neisser-Svae, and Gerhard Gruber. "Protein-Biochemical Characterisation of Wilate®: Determination of the Upper Residual Moisture Limit during Terminal Dry-Heat Treatment (PermaHeat)." Blood 106, no. 11 (2005): 4066. http://dx.doi.org/10.1182/blood.v106.11.4066.4066.

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Abstract Purpose: Wilate® is a novel, human plasma-derived, high purity, double virus inactivated coagulation factor concentrate. The safe and effective treatment of von Willebrand disease patients and haemophilia A has been demonstrated in clinical trials. The very high virus safety is achieved by an optimised solvent/detergent (S/D) method and terminal dry-heat treatment (PermaHeat) of the lyophilised product, not affecting the integrity of the proteins, which was investigated in this study. Methods: Analyses of PermaHeat treated (+100°C for 120 min) Wilate® samples with different residual m

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18

Gokhale, S. G., Thomas Scorer, and H. Doughty. "Freedom from frozen: the first British military use of lyophilised plasma in forward resuscitation." Journal of the Royal Army Medical Corps 162, no. 1 (2014): 63–65. http://dx.doi.org/10.1136/jramc-2014-000361.

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19

Hirst, C. F., and L. Poller. "The cause of turbidity in lyophilised plasmas and its effects on coagulation tests." Journal of Clinical Pathology 45, no. 8 (1992): 701–3. http://dx.doi.org/10.1136/jcp.45.8.701.

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20

van den Besselaar, A. M. "Field study of lyophilised plasmas for local prothrombin time calibration in The Netherlands." Journal of Clinical Pathology 50, no. 5 (1997): 371–74. http://dx.doi.org/10.1136/jcp.50.5.371.

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21

Sicard, Bruno, Frédéric Marouzé, Céline Roche, Mathieu Carron, Sylvain Ausset, and Anne Sailliol. "Bleeding management in remote environment: the use of fresh whole blood transfusion and lyophilised plasma." International Maritime Health 67, no. 2 (2016): 79–82. http://dx.doi.org/10.5603/imh.2016.0016.

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22

Cespedes, B., Y. S. Wong, P. Poblete, et al. "249 Lyophilised platelet-rich plasma stimulates migration of equine endometrial mesenchymal stem and epithelial cells." Reproduction, Fertility and Development 35, no. 2 (2022): 254. http://dx.doi.org/10.1071/rdv35n2ab249.

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23

Gray, Elaine, William M. Pickering, Alison H. Goodall, and Trevor W. Barrowcliffe. "Comparison of the Procoagulant Activity of Freeze-Dried and Fresh Platelets with Phospholipid in Three Phospholipid Dependent Assays." Blood 104, no. 11 (2004): 3990. http://dx.doi.org/10.1182/blood.v104.11.3990.3990.

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Abstract Background and Objective: Platelet activation and coagulation together determine the haemostatic activity of plasma. When activated, platelets expose phosphatidylserine (PS) at their outer surface, on which the tenase and prothrombinase complexes assemble, forming FXa and thrombin, respectively. In in-vitro tests phospholipid vesicles are normally used as a platelet substitute. However it is not clear if PL vesicles behave in the same way as platelets. The objective of the study was to compare and contrast the procoagulant activity (PCA) of lyophilized platelets, a bovine brain phosph

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Kuhn, Antonia I., Marc Müller, Sara Knigge, and Birgit Glasmacher. "Novel blood protein based scaffolds for cardiovascular tissue engineering." Current Directions in Biomedical Engineering 2, no. 1 (2016): 5–9. http://dx.doi.org/10.1515/cdbme-2016-0005.

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AbstractA major challenge in cardiovascular tissue engineering is the fabrication of scaffolds, which provide appropriate morphological and mechanical properties while avoiding undesirable immune reactions. In this study electrospinning was used to fabricate scaffolds out of blood proteins for cardiovascular tissue engineering. Lyophilised porcine plasma was dissolved in deionised water at a final concentration of 7.5% m/v and blended with 3.7% m/v PEO. Electrospinning resulted in homogeneous fibre morphologies with a mean fibre diameter of 151 nm, which could be adapted to create macroscopic

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Raftis, Jennifer, Andrew Lucking, Amanda Hunter, et al. "Lyophilised reconstituted human platelets increase thrombus formation in a clinical ex vivo model of deep arterial injury." Thrombosis and Haemostasis 108, no. 07 (2012): 176–82. http://dx.doi.org/10.1160/th12-02-0059.

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SummaryPlatelets are the principal component of the innate haemostatic system that protect from traumatic bleeding. We investigated whether lyophilised human platelets (LHPs) could enhance clot formation within platelet-free and whole blood environments using an ex vivo model of deep arterial injury. Lyophilised human platelets were produced from stored human platelets and characterised using conventional, fluorescent and electron microscopic techniques. LHPs were resuspended in platelet-free plasma (PFP) obtained from citrated whole human blood to form final concentrations of 0,20 and 200 × 1

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Clarke, K., D. A. Taberner, J. M. Thomson, J. A. Morris, and L. Poller. "Assessment of value of calibrated lyophilised plasmas to determine International Sensitivity Index for coagulometers." Journal of Clinical Pathology 45, no. 1 (1992): 58–60. http://dx.doi.org/10.1136/jcp.45.1.58.

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Rengarajoo, Jonathan, Wei Cheong Ngeow, and Norliza Binti Ibrahim. "The effects of lyophilised platelet-rich plasma in third molar extraction sockets and its surrounding tissues." Journal of Taibah University Medical Sciences 17, no. 2 (2022): 289–96. http://dx.doi.org/10.1016/j.jtumed.2021.10.015.

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28

Gaffney, Patrick J., and Tracey A. Edgell. "The International Standard for Plasminogen Activator Inhibitor-1 (PAI-1) Activity." Thrombosis and Haemostasis 76, no. 01 (1996): 080–83. http://dx.doi.org/10.1055/s-0038-1650526.

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SummarySince the finding that plasminogen activator inhibitor-1 (PAI-1) may influence the initiation and progression of acute myocardial infarction, the assay of PAI-1 in plasma using a variety of commercial kits has become commonplace. The need for a standard to define the activity of PAI-1 prompted an international collaborative study (ICS) to calibrate the functional potency of a lyophilised plasma PAI-1 preparation (92/654). Since PAI-1 inhibits the 2 major plasminogen activators, tissue-type plasminogen activator (t-PA) and urinary-type plasminogen activator (u-PA) in an equimolar manner

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29

Thomson, Jean M., K. V. Darby, and L. Poller. "Calibration of BCT/441, the ICSH Reference Preparation for Thromboplastin." Thrombosis and Haemostasis 55, no. 03 (1986): 379–82. http://dx.doi.org/10.1055/s-0038-1661568.

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SummaryAn international collaborative exercise has been undertaken to calibrate a secondary international reference preparation (IRP) of thromboplastin on behalf of the International Committee for Standardization in Haematology (ICSH). This preparation of British Comparative Thromboplastin (BCT/441) is required because supplies of the WHO primary IRP (BCT/253) are necessarily limited.The calibration was performed at seven centres with only a small degree of interlaboratory variation. As a result of this study an ISI value of 1.04 has been assigned to the preparation.Opportunity was also taken

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30

Yeung, Chi-Yung, Pai-Shan Hsieh, Lin-Gwei Wei, et al. "Efficacy of Lyophilised Platelet-Rich Plasma Powder on Healing Rate in Patients With Deep Second Degree Burn Injury." Annals of Plastic Surgery 80 (February 2018): S66—S69. http://dx.doi.org/10.1097/sap.0000000000001328.

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31

Jennings, I., S. Kitchen, T. A. L. Woods, F. E. Preston, and M. Greaves. "Potentially Clinically Important Inaccuracies in Testing for the Lupus Anticoagulant: an Analysis of Results from three Surveys of the UK National External Quality Assessment Scheme (NEQAS) for Blood Coagulation." Thrombosis and Haemostasis 77, no. 05 (1997): 0934–37. http://dx.doi.org/10.1055/s-0038-1656080.

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SummaryThe identification of the presence of antiphospholipid in plasma is recognised to be of diagnostic and prognostic importance in subjects with thrombotic disease, recurrent miscarriage or collagen vascular disorders. A number of coagulation assays are currently employed for the detection of lupus anticoagulant (LA), many of which are influenced by reagent dependent and methodological variables.In the present study lyophilised plasma samples from three subjects with “strong”, “weak” and “absent” LA were tested in 220 centres. The most commonly used tests for LA were Activated Partial Thro

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Rohde, Gabriele, Gertrud Stratmann, Christian Hesse, et al. "Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin." Thrombosis and Haemostasis 108, no. 07 (2012): 191–98. http://dx.doi.org/10.1160/th11-12-0832.

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SummaryRivaroxaban is a direct factor Xa inhibitor, which can be monitored by anti-factor Xa chromogenic assays. This ex vivo study evaluated different assays for accurate determination of rivaroxaban levels. Eighty plasma samples from patients receiving rivaroxaban (Xarelto®) 10 mg once daily and 20 plasma samples from healthy volunteers were investigated using one anti-factor Xa assay with the addition of exogenous antithrombin and two assays without the addition of antithrombin. Two different lyophilised rivaroxaban calibration sets were used for each assay (low concentration set: 0, 14.5,

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33

Egberg, Nils, Gunnar Nordin, Lennart Stigendal, Inger Fagerberg, Tomas Lindahl, and Andreas Hillarp. "Local INR calibration of the Owren type prothrombin assay greatly improves the intra- and interlaboratory variation." Thrombosis and Haemostasis 91, no. 02 (2004): 300–307. http://dx.doi.org/10.1160/th03-07-0419.

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SummaryIn 1999, a simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced by a working group of the organisation for national quality assurance in laboratory medicine in Sweden. The new protocol allowed local calibration by means of only two lyophilised national plasma calibrators and expression of results as an international normalized ratio (INR). This is our report of a three-year follow-up involving the analysis of data from all laboratories, in hospitals (n=88 in 2002) and primary health care units (n=246 in 2002) that perform the Owren PT assay

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Raby, Anne, Karen Moffat, Greg Flynn, Mark Crowther, and Adam Cuker. "Interlaboratory variation in heparin monitoring: Lessons from the Quality Management Program of Ontario coagulation surveys." Thrombosis and Haemostasis 104, no. 10 (2010): 837–44. http://dx.doi.org/10.1160/th10-02-0099.

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SummaryUnfractionated heparin (UFH) monitoring is subject to substantial inter-laboratory variation. We analysed results of annual coagulation surveys administered by the Quality Management Program – Laboratory Services (Toronto, ON, Canada) from 2003 to 2007 to evaluate variation in UFH monitoring across Ontario. Participating laboratories performed an activated partial thromboplastin time (APTT) utilising their local methodology on lyophilised human plasma spiked with UFH. In the 2006 and 2007 surveys, laboratories licensed to perform anti-Xa assays also reported anti-Xa activity results. Th

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Bader, R., P. M. M. Mannucci, A. Tripodi, et al. "Multicentric Evaluation of a New PT Reagent Based on Recombinant Human Tissue Factor and Synthetic Phospholipids." Thrombosis and Haemostasis 71, no. 03 (1994): 292–99. http://dx.doi.org/10.1055/s-0038-1642433.

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SummaryA new PT reagent based on recombinant human tissue factor and synthetic phospholipids (phosphatidyl choline and phosphatidyl serine) with defined fatty acid side chains was calibrated against BCT/253 and CRM 149R. A small but consistent bias in the International Sensitivity Index (ISI) value was obtained using either the human or rabbit brain reference material. ISI values were around 1.0 or slightly lower depending on the respective instrument. Mixing studies with factor deficient plasmas showed a high factor sensitivity especially for factor VII as compared to commercial rabbit brain

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U, Vyas Pooja, Khobragade Deepak S, Mundhada Dharmendra R, Shrivastava Sandeep P, MundhadaVyas Ujwal B, and Pethe Anil M. "Preclinical Evaluation of Effi cacy of Processed PRP and Fresh PRP in Diabetic Wound Healing." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 01 (2023): 133–38. http://dx.doi.org/10.25258/ijpqa.14.1.23.

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Background: One in four people with diabetes will experience diabetic wounds at some point in their lifespan, which is among the diabetes complications that have the worst eff ects on quality of life. The study’s objective was a comparative preclinical study of the effi cacy of fresh platelet-rich plasma (PRP) Vs L-PRP in diabetic wound. Methods: Twenty four rabbits were used to study the effi cacy. Diabetes was generated in the rabbits, and the diabetic wound’s perilesional region received PRP treatment. The comparative evaluation by done by counting the wound area and rate of healing. Result

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Flaujac, Claire, Xavier Delavenne, Sara Quenet, et al. "Assessment of apixaban plasma levels by laboratory tests: suitability of three anti-Xa assays." Thrombosis and Haemostasis 111, no. 02 (2014): 240–48. http://dx.doi.org/10.1160/th13-06-0470.

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SummaryWhile laboratory monitoring is not required in patients treated with apixaban, a direct factor-Xa inhibitor, assessment of its concentration is useful in some critical situations. However, few data are available on its effect on coagulation tests and on the suitability of anti-Xa assays for its quantification. It was the objective of this study to identify laboratory tests suitable for apixaban concentration assessment. Coagulation tests – PT and aPTT- and anti-Xa assays were performed in apixaban-spiked plasma samples. To evaluate the sensitivity of PT and aPTT to apixaban, we conducte

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Weng, Hsin-Pei, Yuan-Yang Cheng, Hsin-Lun Lee, Tai-Yi Hsu, Yu-Tang Chang, and Yao-An Shen. "Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts." International Journal of Molecular Sciences 22, no. 23 (2021): 12623. http://dx.doi.org/10.3390/ijms222312623.

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As a source of growth factors for expediting wound healing and tissue regeneration, plasma-rich plasma (PRP) has been extensively applied in diverse fields including orthopaedics, ophthalmology, oral and maxillofacial surgery, dentistry, and gynaecology. However, the function of PRP in metabolic regulations remains enigmatic. A standardized method was devised herein to enrich growth factors and to lyophilize it as enhanced PRP (ePRP) powder, which could become ubiquitously available without mechanical centrifugation in clinical practice. To identify metabolic reprogramming in human dermal fibr

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Morris, Jonathan, and Simon Hughes. "UK Helicopter Emergency Medical Services’ use of circulatory access devices, blood product transfusion and fluid warmers – a cross-sectional survey." Trauma 22, no. 1 (2018): 45–50. http://dx.doi.org/10.1177/1460408618819642.

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Introduction The pre-hospital environment provides significant challenges to clinicians who wish to rapidly administer warmed blood products and fluids to patients with haemorrhagic shock. Large-bore circulatory access is required with the use of devices that will successfully warm cold blood with minimal impact on flow rates. Until now, no information has been available that defines UK Helicopter Emergency Medical Services’ (HEMS) use of circulatory access and fluid warming devices, nor the recent adoption of pre-hospital blood product transfusion. Methods A survey was sent to all 22 UK HEMS

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Tapas Pramanik and Tapas Kumar Sur. "Presence of antioxidants and nitric-oxide precursors in Mimosa pudica extract." GSC Advanced Research and Reviews 7, no. 3 (2021): 104–8. http://dx.doi.org/10.30574/gscarr.2021.7.3.0124.

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Blood pressure lowering effect of Mimosa pudica induced by dieresis was reported earlier. As a diuretic it enhances urine outflow, decreases plasma volume, venous return; and thereby, reduce blood pressure. Besides the diuretic agent, some other blood pressure lowering substance may also be present in Mimosa pudica. Present study was undertaken to reveal the presence of antioxidants and nitrite in Mimosa pudica extract, which may help to reduce blood pressure. Methanolic extract of Mimosa pudica (using 80% methanol) was lyophilised to obtain dried Mimosa pudica Extract (MPE). For Total phenoli

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Javaudin, Olivier, A. Baillon, N. Varin, et al. "Air-drop blood supply in the French Army." Journal of the Royal Army Medical Corps 164, no. 4 (2018): 240–44. http://dx.doi.org/10.1136/jramc-2017-000886.

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BackgroundHaemorrhagic shock remains the leading cause of preventable death in overseas and austere settings. Transfusion of blood components is critical in the management of this kind of injury. For French naval and ground military units, this supply often takes too long considering the short shelf-life of red blood cell concentrates (RBCs) and the limited duration of transport in cooling containers (five to six days). Air-drop supply could be an alternative to overcome these difficulties on the condition that air-drop does not cause damage to blood units.MethodsAfter a period of study and te

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Bailleul, Els, Bernard Chatelain, Anne Demulder, et al. "Influence of dabigatran and rivaroxaban on routine coagulation assays." Thrombosis and Haemostasis 113, no. 01 (2015): 154–64. http://dx.doi.org/10.1160/th14-02-0161.

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SummaryThe Belgian national External Quality Assessment Scheme performed a nationwide survey using lyophilised plasma samples spiked with dabigatran or rivaroxaban to demonstrate to the Belgian clinical laboratories how these drugs affect their routine coagulation assays prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and antithrombin. Virtually all Belgian laboratories performing routine coagulation testing (189/192) participated in the survey. Both, dabigatran and rivaroxaban significantly prolonged the PT and aPTT in a concentration- and reagent-dependent man

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Poller, L. "European Concerted Action on Anticoagulation (ECAA). An assessment of lyophilised plasmas for ISI calibration of CoaguChek and TAS whole blood prothrombin time monitors." Journal of Clinical Pathology 56, no. 2 (2003): 114–19. http://dx.doi.org/10.1136/jcp.56.2.114.

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Slobodan, Petrović, Maletić Milan, Lakić Nada, et al. "The Effects of Antioxidants Provided with Feed on Certain Quality Parameters of Bull Semen Under Heat Stress Conditions." Acta Veterinaria 70, no. 4 (2020): 453–70. http://dx.doi.org/10.2478/acve-2020-0034.

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Abstract The aim of the current research was to assess the effects of the feed additive made of lyophilised melon juice (source of superoxide dismutase, SOD) and inactivated live Saccharomyces cerevisiae (strain R397) cells added to the feed via the product containing high levels of organically bound selenium (source of selenium-dependant glutathione peroxidase, Se-GPx) on the semen quality of bulls in heat stress conditions. The 15 bulls chosen for the experiment were assigned to three equal groups (control –group C; treated group M, given the source of SOD; and group A, treated with the sour

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Pollard, Debra, Kate Khair, Cléa Percier, Yen Wong, and Robyn Shoemark. "Evaluation of MixPro® among users and nurses." Journal of Haemophilia Practice 5, no. 1 (2018): 12–23. http://dx.doi.org/10.17225/jhp00106.

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Abstract Management of haemophilia involves on-demand or prophylactic intravenous administration of recombinant or plasma-derived replacement clotting factors or bypassing agents. These products are provided as lyophilised powder and diluent, which need to be mixed to produce a solution for infusion. While this process has previously involved multiple time-consuming steps, several reconstitution systems are now available to make mixing easier and more convenient. This study aimed to investigate experience of use and perceptions of the Novo Nordisk MixPro® mixing device among patients and carer

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Tapas, Pramanik, and Kumar Sur Tapas. "Presence of antioxidants and nitric-oxide precursors in Mimosa pudica extract." GSC Advanced Research and Reviews 7, no. 3 (2021): 104–8. https://doi.org/10.5281/zenodo.5074689.

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Blood pressure lowering effect of <em>Mimosa pudica</em> induced by dieresis was reported earlier. As a diuretic it enhances urine outflow, decreases plasma volume, venous return; and thereby, reduce blood pressure. Besides the diuretic agent, some other blood pressure lowering substance may also be present in <em>Mimosa pudica</em><em>. </em>Present study was undertaken to reveal the presence of antioxidants and nitrite in <em>Mimosa pudica</em> extract, which may help to reduce blood pressure. Methanolic extract of <em>Mimosa pudica</em> (using 80% met

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Favaloro, Emmanuel. "Collagen Binding Assay for von Willebrand Factor (VWF:CBA): Detection of von Willebrands Disease (VWD), and Discrimination of VWD Subtypes, Depends on Collagen Source." Thrombosis and Haemostasis 83, no. 01 (2000): 127–35. http://dx.doi.org/10.1055/s-0037-1613768.

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SummaryA large number of different collagen preparations [n = 21] have been assessed for their ability to both detect von Willebrands Disease (VWD), and discriminate different VWD subtypes. Collagen preparations were tested at a range of concentrations and included: Type I, III and IV, and various mixtures of these, as aqueous supplied preparations and/or reconstituted from bulk lyophilised stock. Tissue sources for collagens ranged from human placenta to calf skin to equine tendon. Three of the collagen preparations tested did not support von Willebrand factor (VWF) binding in an ELISA proces

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Lammasak, Kanokporn, Suwanna Kijpakorn, and Kris Angkanaporn. "Porcine bile powder supplementation of a high fat broiler diet in relation to growth performance and nutrient digestion." Animal Production Science 59, no. 7 (2019): 1310. http://dx.doi.org/10.1071/an18190.

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The aim of the study was to examine the effect of pig bile powder supplementation on the digestibility of nutrients, fat digestion and growth performance of starter broilers fed on a high fat diet. A total of 1110, day-old, male broiler chicks (Arbor Acres) were randomly allocated into six treatment groups with five replicates per treatment. The chicks were fed on a corn-soybean meal basal diet with a starter formulation until Day 14, followed by a grower formulation until Day 21. In group 1 (T1), the basal diet contained 30 g/kg crude palm oil whereas the diet used in group 2 (T2) had 60 g/kg

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Lammasak, Kanokporn, Suwanna Kijpakorn, and Kris Angkanaporn. "Corrigendum to: Porcine bile powder supplementation of a high fat broiler diet in relation to growth performance and nutrient digestion." Animal Production Science 59, no. 7 (2019): 1399. http://dx.doi.org/10.1071/an18190_co.

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The aim of the study was to examine the effect of pig bile powder supplementation on the digestibility of nutrients, fat digestion and growth performance of starter broilers fed on a high fat diet. A total of 1110, day-old, male broiler chicks (Arbor Acres) were randomly allocated into six treatment groups with five replicates per treatment. The chicks were fed on a corn-soybean meal basal diet with a starter formulation until Day 14, followed by a grower formulation until Day 21. In group 1 (T1), the basal diet contained 30 g/kg crude palm oil whereas the diet used in group 2 (T2) had 60 g/kg

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Meijer, Piet, Richard A. Marlar, John M. Teare, and Dorothy Adcock. "Inter-Laboratory Evaluation of the Recovery of Bay 94-9027 [Jivi®] with One-Stage Clotting and Chromogenic Assays." Blood 134, Supplement_1 (2019): 1124. http://dx.doi.org/10.1182/blood-2019-125491.

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Introduction Hemophila A patients treated with replacement products are routinely monitored for Factor VIII (FVIII) activity during therapy using either one-stage clotting assays (OSA) or chromogenic assays (CA). It is well known that laboratory assay results can be affected by extended half-life FVIII products. BAY 94-9027 (damoctocog alfa pegol; Jivi®) is a site-specific pegylated FVIII in which a 60-kDA PEG is conjugated to an introduced cysteine residue substitution on the light chain of B-domain deleted FVIII. The purpose of this study was to investigate the characteristics of BAY 94-9027

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