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Dissertations / Theses on the topic 'Plasma therapy'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Leese, Trevor. "Fresh frozen plasma therapy in acute pancreatitis." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/34130.

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Despite improvements in general supportative measures, the mortality from acute pancreatitis in the United Kingdom, still approaches 10%. Although many specific therapies have been proposed, none has consistently been shown to improve outcome in controlled clinical trials. Intravenous fresh frozen plasma has been advocated as a therapy for acute pancreatitis. It may supplement declining natural antiprotease capacity, particularly alpha2 macroglobulin which appears to have a central role in the elimination of disseminated pancreatic enzymes in man. Initially, the effect of fresh frozen plasma t

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2

JAFER, RASHIDA. "Laser plasma protons and applications in cancer therapy and proton radiography." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7457.

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Recent developments in high power, ultrashort pulse laser systems enable laser intensities beyond 10^21 W/cm^2 to be achieved. When focused onto thin foil targets, plasmas with extremely high electrostatic fields (>10^12V/m) are produced, resulting in the acceleration of protons/ions to very high energies (~60MeV). During my PhD, I have worked on experimental investigations into proton acceleration driven by high power laser pulses. Key to successful deployment of laser proton sources one one side is getting higher proton energies through to achieve the ultimate goal of realising table top mac

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3

Isolan, Lorenzo <1989&gt. "Development and Implementation of the Plasma Focus Technology for Radiation Therapy Applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10207/1/Isolan_Lorenzo_tesi.pdf.

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A Plasma Focus device can confine in a small region a plasma generated during the pinch phase. When the plasma is in the pinch condition it creates an environment that produces several kinds of radiations. When the filling gas is nitrogen, a self-collimated backwardly emitted electron beam, slightly spread by the coulomb repulsion, can be considered one of the most interesting outputs. That beam can be converted into X-ray pulses able to transfer energy at an Ultra-High Dose-Rate (UH-DR), up to 1 Gy pulse-1, for clinical applications, research, or industrial purposes. The radiation fields have

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4

Davies, Philip Andrew. "Physical and engineering aspects of protein separation processes." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253017.

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5

Hirst, Adam. "Development of low temperature plasma as a novel focal therapy for prostate cancer." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/13969/.

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Cancer of the prostate is the most common male malignancy. Despite continual refinement, the treatment of localised prostate cancer remains unsatisfactory. Patients are often faced with the choice between invasive radical surgery and the risk of impotence, or radiological techniques with associated off-target toxicity and incomplete tumour ablation. Low temperature plasma (LTP) may present a completely new approach for the focal treatment of localised prostate cancer. LTPs create a rich source of reactive oxygen and nitrogen species, plus energetic photons, charged particles, and localised ele

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6

Frank, Johanna R. "Interleukin-11 therapy in dogs, mechanisms of plasma volume expansion and cardiovascular effects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0001/NQ43257.pdf.

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7

Hamouda, Inés. "Synthesis and characterization of plasma-treated liquid and hydrogels for bone cancer therapy." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/673066.

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This PhD Thesis tallies with the Starting Grant project funded by the European Research Council (ERC) entitled “Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEaling” (APACHE) and has been carried out within the Biomaterials, Biomechanics and Tissue Engineering group (BBT) at the Barcelona East School of Engineering (EEBE) of the Universitat Politècnica de Catalunya (UPC). This project falls within in the area of Plasma Medicine, a new branch of medical technology encompassing physics, biology, medicine and chemistry. One of the main fields of interest in Plasma Medicine is ca

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8

Chaworth-Musters, Tessa. "Plasma concentrations of nelfinavir and viral suppression in HIV-1 infected pregnant women." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/965.

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BACKGROUND: Highly active antiretroviral therapy(HAART) is used in pregnancy to suppress viral load(pVL) before delivery, reducing risk of vertical HIV-transmission. Nelfinavir(NFV) containing HAART has been highly used in pregnancy, but dosages may be inadequate due to the physiologic changes that occur. Given concerns regarding optimal viral suppression in pregnancy, drug toxicity and resistance development, NFV levels need to be evaluated in this population to guide dosing recommendations. METHODS: As part of a prospective cohort study maternal blood was collected at 18-28wks, 32-37wks and

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9

Connolly, Richard J. "Plasma Mediated Molecular Delivery." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3450.

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Non-viral delivery of plasmid DNA has traditionally relied upon physical forces applied directly to target tissues. These physical methods typically involve contact between an applicator and the target tissue and often cause transient patient discomfort. To overcome the contact-dependent limitations of such delivery methodologies, an atmospheric direct current plasma source was developed to deposit ionized gas molecules onto localized treatment sites. The deposition of charged species onto a treatment site can lead to the establishment of an electric field with strengths similar to those used

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10

Duncan, Kaylia Mekelda. "Dynamics of tumor progression and therapy response in Il-6 and Myc driven plasma cell malignancy." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4619.

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Emerging evidence indicates that 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) are useful imaging modalities for evaluating tumor progression in transgenic mouse models of solid human cancers, but the potential of integrated FDG-PET/CT for assessing tumor development in genetically engineered mouse models of liquid human cancers - including neoplasms of immunoglobulin (Ig)-producing plasma cells - has not been established. Here we use a double-transgenic strain of laboratory mice, designated C.IL6Myc, that recapitulates key features of human plasma

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11

Ceccolini, Elisa <1983&gt. "Development and performance assessment of a Plasma Focus electron beam generator for Intra-Operative Radiation Therapy." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4736/1/Ceccolini_Elisa_tesi.pdf.

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The Plasma Focus is a device designed to generate a plasma sheet between two coaxial electrodes by means of a high voltage difference. The plasma is then driven to collapse into a “pinch”, where thermonuclear conditions prevail. During the “pinch phase” charged particles are emitted, with two main components: an ion beam peaked forward and an electron beam directed backward. The electron beam emitted backward by Plasma Focus devices is being investigated as a radiation source for medical applications, using it to produce x-rays by interaction with appropriate targets (through bremsstrahlung an

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12

Ceccolini, Elisa <1983&gt. "Development and performance assessment of a Plasma Focus electron beam generator for Intra-Operative Radiation Therapy." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4736/.

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The Plasma Focus is a device designed to generate a plasma sheet between two coaxial electrodes by means of a high voltage difference. The plasma is then driven to collapse into a “pinch”, where thermonuclear conditions prevail. During the “pinch phase” charged particles are emitted, with two main components: an ion beam peaked forward and an electron beam directed backward. The electron beam emitted backward by Plasma Focus devices is being investigated as a radiation source for medical applications, using it to produce x-rays by interaction with appropriate targets (through bremsstrahlung an

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13

Bhardwaj, Gourav [Verfasser]. "Proteomic analysis of endomyocardial biopsies and plasma of dilated cardiomyopathy patients treated by immunoadsorption therapy / Gourav Bhardwaj." Greifswald : Universitätsbibliothek Greifswald, 2016. http://d-nb.info/1119751233/34.

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14

Cohen, Karen. "Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3277.

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Includes bibliographical references.<br>Sub-Saharan Africa is overwhelmed by dual epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB) infection. Non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based antiretroviral therapy (ART) is recommended for first-line treatment in adult HIV treatment programmes in resource-limited settings [1]. Many South African HIV-infected patients initiate ART while on TB treatment, 38 percent in one local study [2]. In addition, although ART reduces the incidence of TB, incidence in patients on ART is higher than in the HIV uninfected popula

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15

MANCINI, GIULIA. "GANGLIOSIDE GM1 AS ADJUVANT FOR ORKAMBI® THERAPY TO RESTORE PLASMA MEMBRANE STABILITY AND FUNCTION OF F508DEL-CFTR." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/604127.

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Cystic fibrosis (CF) is the most common, fatal genetic disease in the Caucasian population caused by loss of function mutations in gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is expressed at the apical surface of epithelial cells of different organs, such as: lungs, pancreas, gut, and testes. For this reason even if in CF the pulmonary manifestations are the most severe, CF is considered a multi-system disease, which affects several bodily districts. The new challenge for the CF therapy is based on the development of small molecules able to rescue t

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16

Garcez, Tuane Nerissa Alves. "Células-tronco mesenquimais e plasma rico em plaquetas como adjuvantes da cicatrização de lesões cutâneas experimentais em coelhos Nova Zelândia." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/60993.

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Muito se tem investido em pesquisa na compreensão dos processos e fenômenos envolvidos nas diversas fases da reparação tissular e, principalmente, no desenvolvimento de recursos e tecnologias com o objetivo de favorecer os avanços no tratamento de feridas. Este trabalho foi realizado com o objetivo de avaliar os efeitos biológicos da associação células-tronco mesenquimais (CTMs) e plasma rico em plaquetas (PRP) como adjuvantes da cicatrização cutânea de feridas padronizadas em coelhos. Foram utilizados 37 coelhos Nova Zelândia, dentre os quais, 36 foram distribuídos em seis grupos: grupo contr

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17

Perez, Amanda Gomes Marcelino 1979. "Preparation, modulation, encapsulation and controlled release of platelet-rich plasma for application in regenerative therapy = Preparação, modulação, encapsulação e liberação controlada de plasma rico em plaquetas para aplicação em terapia regenerativa." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266597.

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Orientadores: Maria Helena Andrade Santana, William Dias Belangero<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química<br>Made available in DSpace on 2018-08-23T23:34:26Z (GMT). No. of bitstreams: 1 Perez_AmandaGomesMarcelino_D.pdf: 5504365 bytes, checksum: dfd77169a41938bfecc5af20b2eddd27 (MD5) Previous issue date: 2013<br>Resumo: O plasma rico em plaquetas (PRP) é um tratamento autólogo, portanto não imunogênico, capaz de estimular e acelerar a regeneração tecidual. A qualidade do PRP preparado é fundamental para o sucesso da sua aplicação clínica. Apes

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18

Le, Quellec Sandra. "When engineering new recombinant factor IX molecules meets gene therapy : improvement of factor IX plasma level in patients with haemophilia B?" Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1011/document.

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Introduction : L’hémophilie B (HB) est une maladie hémorragique héréditaire caractérisée par un déficit en facteur IX (FIX) de la coagulation. La thérapie génique de l’HB par injection de virus adéno-associés (AAV) montre des résultats prometteurs, mais entraine une toxicité hépatique à forte dose. La création de nouveau transgène de FIX permettant d’injecter de moindres doses d’AAV est un réel enjeu. Matériel et Méthodes : Des transgènes thérapeutiques exprimant une protéine humaine de FIX à demi-vie prolongée par fusion à l’albumine (hFIX-Alb) ou exprimant un FIX une activité spécifique augm

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19

Eisenhofer, Graeme, Sebastian Brown, Mirko Peitzsch, et al. "Levodopa therapy in Parkinson’s disease: Influence on liquid chromatographic tandem mass spectrometricbased measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine." Sage, 2014. https://tud.qucosa.de/id/qucosa%3A35427.

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Background: Medication-related interferences with measurements of catecholamines and their metabolites represent important causes of false-positive results during diagnosis of phaeochromocytomas and paragangliomas (PPGLs). Such interferences are less troublesome with measurements by liquid chromatography with tandem mass-spectrometry (LC-MS/MS) than by other methods, but can still present problems for some drugs. Levodopa, the precursor for dopamine used in the treatment of Parkinson’s disease, represents one potentially interfering medication. Methods: Plasma and urine samples, obtained from

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20

Ewaldsson, Carl-Arne. "The effect of anaesthesia and adrenergic therapy on the distribution and elimination of a crystalloid solution studied by volume kinetic analysis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-914-9/.

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21

Rabello, Ariele Patricia. "Efeito da laserterapia e do plasma rico em plaquetas em dentes reimplantados tardiamente : análise histológica, histoquímica e por microtomografia computadorizada /." Araraquara, 2017. http://hdl.handle.net/11449/151499.

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Orientador: Fabio Luiz Camargo Villela Berbert<br>Resumo: O melhor tratamento para dentes permanentes avulsionados é o reimplante imediato, porém, quando o dente permanece fora do alvéolo por longo período, o prognóstico pode ser prejudicado. Condutas têm sido buscadas na tentativa de melhorar os problemas decorrentes de reimplantes tardios. A laserterapia, devido à sua propriedade anti-inflamatória, e o plasma rico em plaquetas (PRP), devido à liberação de fatores de crescimento, são boas alternativas visando atenuar o processo inflamatório e auxiliar o processo de reparo. Avaliou-se os efeit

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22

Ramos, Paula Andrea Ramirez. "Efeito do plasma rico em plaquetas associado ao uso do LASER terapêutico em desmite proximal do ligamento suspensor do boleto." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-03092014-160828/.

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A cicatrização das lesões ligamentares é lenta e muitas vezes ineficiente. Uma vez lesado, o ligamento suspensor do boleto (LSB) dificilmente recupera suas propriedades biomecânicas originais. A desmite do LSB proximal dos membros torácicos ocorre em cavalos de todas as raças e todas as disciplinas esportivas. O objetivo deste trabalho foi avaliar clinicamente e por ultrassonografia, a influência do plasma rico em plaquetas (PRP), e do PRP associado ao LASER terapêutico, na cicatrização da região proximal do LSB, em cavalos com desmite induzida por colagenase. Para isto foram utilizados 18 ani

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23

Chandrasekaran, Badrinathan. "The effect of cardiac resynchronisation therapy on left ventricular remodelling, plasma apelin and cytokine levels in patients with heart failure with systolic dysfunction." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10726.

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Aims: To investigate the human production of the vasodilating, inotropic peptide apelin in heart failure (HF) and the effect of cardiac resynchronisation therapy (CRT) on left ventricular remodelling (LVR), venous apelin, serum cytokines and their soluble receptors in humans. Methods: Plasma apelin and B-type natriuretic peptide (BNP) were measured in coronary sinus (CS), Aorta (Ao) and renal vein (RV) of patients with HF and healthy controls. In a population of patients who were eligible for CRT clinical parameters apelin, soluble ST2 (sST2), and an array of cytokines: Interferon (IFN)-γ, Int

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24

Ren, Yuan. "The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3297.

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Background: Tuberculosis (TB) is the most common opportunistic infection in children with human immunodeficiency virus (HIV) infection in developing countries, and co-treatment for HIV infection and TB is frequently indicated. Efavirenz and lopinavir/ritonavir (ratio 1:1) as part of antiretroviral therapy are used in combination with rifampicin-based antitubercular treatment in South African TB/HIV co-infected children. Adult studies show that concomitant rifampicin significantly reduces efavirenz and lopinavir plasma concentrations. However, the pharmacokinetics (PK) of efavirenz and lopinavi

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VIDAL, JUNIOR Andr? William Masseaux. "Compara??o entre protocolos para obten??o de plasma rico em plaquetas em c?es: estudo celular." Universidade Federal Rural do Rio de Janeiro, 2017. https://tede.ufrrj.br/jspui/handle/jspui/2444.

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Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-09-13T21:42:04Z No. of bitstreams: 1 2017 - Andr? William Masseaux Vidal J?nior.pdf: 1275550 bytes, checksum: d2d211215832b8ab2e53ab8d6da5ae4b (MD5)<br>Made available in DSpace on 2018-09-13T21:42:04Z (GMT). No. of bitstreams: 1 2017 - Andr? William Masseaux Vidal J?nior.pdf: 1275550 bytes, checksum: d2d211215832b8ab2e53ab8d6da5ae4b (MD5) Previous issue date: 2017-02-15<br>It was proposed by this study to evaluate two protocols (PA and PB) to obtain autologous canine PRP, which is easy to perform in an ambulatory (semiautomatic method)

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Mörschbächer, Priscilla Domingues. "Células-tronco mesenquimais e plasma rico em plaquetas em cardiomiopatia dilatada não isquêmica induzida com doxorrubicina em coelhos Nova Zelândia." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/49948.

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A insuficiência cardíaca é a doença crônica com maior impacto na sobrevida e qualidade de vida dos pacientes. Apesar do constante desenvolvimento de novas estratégias de tratamento, esta doença continua atingindo altos índices de mortalidade. O coração adulto tem capacidade de regeneração limitada e há grande evidência experimental de que os transplantes de células-tronco poderiam ser uma abordagem eficiente na recuperação do miocárdio lesado. Contudo, a maioria dos estudos são realizados em cardiomiopatias isquêmicas, existindo poucos estudos na cardiomiopatia dilatada (CMD). Em função disto,

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Stessuk, Talita. "Terapia celular em úlceras crônicas com implante de células tronco mesenquimais associadas a plasma rico em plaquetas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-29082016-101221/.

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Doenças crônicas sistêmicas, em especial o diabetes mellitus, favorecem o aparecimento e a continuidade de lesões dermo-epidérmicas, sendo o impacto econômico e social significativo. No âmbito da medicina regenerativa para o tratamento de lesões cutâneas crônicas, o emprego clínico da bioengenharia de tecidos associada à terapia celular tem sido considerado uma promissora alternativa terapêutica. Neste contexto, o estudo tem como objetivo avaliar a eficácia terapêutica no tratamento de úlceras cutâneas de pacientes diabéticos, empregando células-tronco mesenquimais do tecido adiposo (CT-TA) as

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Campos, Natália de [UNESP]. "Avaliação da influência do plasma rico em plaquetas e do laser de baixa intensidade na cicatrização de defeitos de fenestração periodontal em ratos: estudo histológico e histométrico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/96156.

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Made available in DSpace on 2014-06-11T19:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-23Bitstream added on 2014-06-13T19:57:14Z : No. of bitstreams: 1 campos_n_me_araca_parcial.pdf: 374524 bytes, checksum: 0e80098f70073718b0c1a9511ce69881 (MD5) Bitstreams deleted on 2015-07-02T12:36:04Z: campos_n_me_araca_parcial.pdf,. Added 1 bitstream(s) on 2015-07-02T12:37:29Z : No. of bitstreams: 1 000674476_20250723.pdf: 374303 bytes, checksum: e8c36bf585abbff4e58e95157dbe1d90 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Este estudo avaliou, histomorfome

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Ozaki, Guilherme Akio Tamura [UNESP]. "Efeitos da terapia a laser associada ou não ao plasma rico em plaquetas na reparação do tecido muscular de ratos." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/128107.

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Made available in DSpace on 2015-10-06T13:03:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-14. Added 1 bitstream(s) on 2015-10-06T13:18:38Z : No. of bitstreams: 1 000848921.pdf: 574953 bytes, checksum: a70399b9991013344e70c1ffa225f94a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes)<br>O tratamento de lesões musculares geralmente resulta na interrupção da atividade esportiva, por isso estudos que visam antecipar o retorno à atividade, com o adequado reparo tecidual se tornam importantes. Sendo assim, o presente estudo objetivou avaliar o efeito da t

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Ozaki, Guilherme Akio Tamura. "Efeitos da terapia a laser associada ou não ao plasma rico em plaquetas na reparação do tecido muscular de ratos /." Presidente Prudente, 2015. http://hdl.handle.net/11449/128107.

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Orientador: José Carlos Silva Camargo Filho<br>Banca: Luiz Carlos Marques Vanderlei<br>Banca: Mário Jefferson Quirino Louzada<br>Resumo: O tratamento de lesões musculares geralmente resulta na interrupção da atividade esportiva, por isso estudos que visam antecipar o retorno à atividade, com o adequado reparo tecidual se tornam importantes. Sendo assim, o presente estudo objetivou avaliar o efeito da terapia a laser de baixa intensidade (LLLT) associada ou não ao plasma rico em plaquetas (PRP) no tratamento de lesão muscular. Foram utilizados 42 animais separados em seis grupos (n=7): Controle

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Roynette, Catherine E. "Effects of a functional oil rich in medium chain triglycerides and phytosterols on plasma lipid profiles and body composition in hypercholesterolemic, overweight men." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84069.

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Localised accumulation of body fat significantly influences the development of obesity related co-morbidities and cardiovascular disease (CVD) risk. Medium chain triglycerides (MCT) have been suggested to modulate body fat distribution. Phytosterols (PS) have demonstrated unequivocal cholesterol-lowering effects. A healthy dietary solution combining MCT and PS could thus become first-line obesity and CVD prevention. The aim of this study was therefore to investigate the effects of a functional oil (FctO) rich in MCT and PS on blood lipid levels and body adiposity, compared to olive oil.

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Bertrand, Baptiste. "Traitement des altérations de la peau par la fraction vasculaire stromale et les produits autologues dérivés du tissu adipeux." Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/190417_BERTRAND_242uf54uog131hnsdbu686cwseau_TH.pdf.

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Certaines altérations de la cicatrisation ou du volume sous cutané sont difficiles à traiter. L’objectif de notre travail de thèse était d’évaluer l’efficacité et la tolérance de produits autologues innovants de thérapie cellulaire dérivés du tissu adipeux. Nous avons étudié l’action de la fraction vasculaire stromale (FVS), obtenue par digestion enzymatique du tissu adipeux, de la Nanofat ou « graisse émulsifiée » et du plasma riche en plaquette (PRP), dans des modèles murins de radiodermite chronique, de plaie diabétique ou chez l’homme pour les ridules péribuccales. L’injection locale de FV

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Rubina, Filipa Ascensão Alves. "A Prospective Double-Blind Placebo Controlled Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/403440.

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Background: Androgenetic Alopecia (AGA) is a nonscarring alopecia that affects both men and women. It is characterized by a progressive miniaturization of hair follicles with a characteristic pattern distribution in genetically predisposed men and women. The currently available treatments for AGA are sometimes perceived as having limited effectiveness, therefore, Platelet-rich plasma (PRP) has been postulated as a new therapy for AGA. Objective: To assess the efficacy of PRP on the evolution of AGA, between 6 months of treatment and baseline. Methods: This was a prospective, randomized, plac

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Sampaio, Thiago Pacheco de Almeida. "Relação entre a concentração de serotonina no plasma rico em plaquetas e a resposta à terapia comportamental baseada em exposição com prevenção de resposta no transtorno obsessivo-compulsivo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-20022009-141000/.

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INTRODUÇÃO: Entre os tratamentos existentes para o transtorno obsessivocompulsivo (TOC) os mais eficazes são o farmacológico, com inibidores de recaptura de serotonina (IRS; inibidores seletivos de recaptura de serotonina [ISRS] e clomipramina), e o comportamental, baseado na técnica de exposição com prevenção de resposta (EPR). Ambas apresentam eficácia semelhante para os sintomas obsessivo-compulsivos e estudos demonstram que a EPR produz modificações neurobiológicas semelhantes às provocadas pelo tratamento com ISRS. Essas evidências sugerem que a resposta clínica à EPR está diretamente rel

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Ettey, Thywill. "An Investigation of Collagen, Platelet-Rich Plasma and Bone Marrow Derived Mesenchymal Stem Cells on Achilles Tendon Repair in a Rat Model." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1559127777520856.

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Pallotta, Rodney Capp. "Avaliação do efeito da radiação laser de baixa potência e do plasma rico em fibrina na reparação óssea em ratos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-25112014-143302/.

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O reparo ósseo é regulado por fases: inflamatória, proliferativa e remodelação, sendo importante para a qualidade do osso. Terapias têm sido estudadas para ajudar neste processo, como Plasma Rico em Fibrina (PRF) e terapia a laser (LBP). No entanto os estudos são controversos. O objetivo deste estudo foi analisar o impacto da LBP com ou sem PRF no reparo após o defeito ósseo crítico em tíbia de ratos. Os animais foram divididos em grupos: hígido, defeito sem tratamento, defeito tratado com 3 doses de LBP, PRF sozinho e associado com LBP. A fim de analisar o processo de reparo, a tíbia foi remo

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Quasso, Fabio. "Elemental profiling as a chemical investigation approach: application to health studies and food authentication." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/97204.

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Oliveira, Clayton Zambeli. "Caracterização funcional e estrutural de inibidores de fosfolipases A2 isolados do plasma de serpente Bothrops jararacussu." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-18052009-210336/.

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As fosfolipases A2 (PLA2s) de peçonhas de serpentes compreendem um grupo de enzimas de massas moleculares variáveis entre 14.000 e 18.000, e são responsáveis por vários efeitos tóxicos induzidos pela peçonha destes animais, tornando-se necessária a busca por inibidores naturais de PLA2¬s. O presente trabalho propôs a caracterização bioquímica, farmacológica e estrutural de duas proteínas inibitórias isoladas do plasma da serpente Bothrops jararacussu (BjussuMIPs), que neutralizam as atividades enzimáticas, tóxicas e farmacológicas de diferentes PLA2s. Estes inibidores foram isolados por cromat

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Sasnouski, Siarhei. "Etude des interactions du photosensibilisant méta-tétra(hydroxyphényl)chlorine avec les protéines de plasma et les cellules." Phd thesis, Université Henri Poincaré - Nancy I, 2006. http://tel.archives-ouvertes.fr/tel-00119552.

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L'étude de l'influence des pharmacocinétiques de la mTHPC dans la tumeur, le plasma et les leucocytes sur la réponse à la PDT a montré que l'accumulation du photosensibilisant dans les leucocytes exhibaient une bonne corrélation avec l'efficacité de la PDT. Ces résultats suggèrent que les leucocytes pourraient jouer un rôle important dans le mécanisme de la PDT induisant des dommages vasculaires. L'étude de la monomérisation de la mTHPC au cours des interactions avec des protéines plasmatiques démontrent un taux lent de cinétique de désagrégation. La fraction de mTHPC agrégée à l'équilibre et

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Brasil, Horus Antony. "Avaliação da aplicação clínica da coagulação com plasma de argônio na ablação do esôfago de Barrett." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-08072008-145428/.

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O objetivo deste trabalho foi avaliar a aplicação clínica e a efetividade da coagulação com plasma de argônio(CPA) usada para realizar a ablação do esôfago de Barrett. A presença desta moléstia é considerada uma condição pré maligna com potencial para o desenvolvimento do adenocarcinoma de esôfago. Um estudo clínico prospectivo foi realizado com um grupo de 30 pacientes portadores de esôfago de Barrett, diagnosticado por meio de endoscopia digestiva alta e histologia. 25 pacientes eram do sexo masculino com idade variando entre 12 e 72 anos (média = 47,1) e 5 pacientes eram do sexo feminino cu

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Esteoulle, Lucie. "Développement de conjugués peptidiques fluorocarbonés pour augmenter la stabilité plasmatique de peptides visant des récepteurs couplés aux protéines G." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF058.

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Afin d’améliorer la stabilité plasmatique de peptides, nous avons développé une nouvelle stratégie basée sur l’introduction d’une chaîne fluorocarbonée dans la séquence d’un peptide natif. En appliquant le concept à l’apeline-17, un peptide présentant un intérêt potentiel pour le traitement de maladies cardiovasculaires, nous avons amélioré sa stabilité plasmatique de 4 min à plus de 24 h ainsi que son efficacité in vivo. L’étude du mécanisme de stabilisation a permis de mettre en évidence la liaison de la fluoroapeline à l’albumine, conduisant à la protection du peptide vis-à-vis de la protéo

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Belem, Eduarda de Lima Graciano [UNESP]. "Aspirado de medula óssea e plasma rico em plaquetas, associados ou não à terapia com laser em baixa intensidade no reparo ósseo: estudo histomorfométrico e imunoistoquímico." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143933.

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Submitted by EDUARDA DE LIMA GRACIANO BELEM null (eduarda.belem@hotmail.com) on 2016-09-19T17:45:24Z No. of bitstreams: 1 Dissertação - Eduarda de Lima Graciano Belem (19-09-16).pdf: 1696256 bytes, checksum: 5d66d1f4ebfc8533efcd6e4b3df8a441 (MD5)<br>Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-09-22T14:58:30Z (GMT) No. of bitstreams: 1 belem_elg_me_araca_par.pdf: 642200 bytes, checksum: cfac5618a8e05e501e2a63bd42199005 (MD5)<br>Made available in DSpace on 2016-09-22T14:58:30Z (GMT). No. of bitstreams: 1 belem_elg_me_araca_par.pdf: 642200 byt

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Häusler, Darius [Verfasser], Imke [Akademischer Betreuer] Metz, Wolfgang [Akademischer Betreuer] Brück, and Alexander [Akademischer Betreuer] Flügel. "Impact of natalizumab therapy on human pathology and an animal model of multiple sclerosis (EAE) with special focus on B cell / plasma cell inflammation / Darius Häusler. Gutachter: Wolfgang Brück ; Alexander Flügel. Betreuer: Imke Metz." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1064147984/34.

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Kasten, Philip, Mirjam Beverungen, Helga Lorenz, Julia Wieland, Michael Fehr, and Florian Geiger. "Comparison of Platelet-Rich Plasma and VEGF-Transfected Mesenchymal Stem Cells on Vascularization and Bone Formation in a Critical-Size Bone Defect." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135985.

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Both platelet-rich plasma (PRP) and vascular endothelial growth factor (VEGF) can promote regeneration. The aim of this study was to compare the effects of these two elements on bone formation and vascularization in combination with bone marrow stromal cells (BMSC) in a critical-size bone defect in rabbits. The critical-size defects of the radius were filled with: (1) a calcium-deficient hydroxyapatite (CDHA) scaffold + phVEGF165-transfected BMSC (VEGF group), (2) CDHA and PRP, or (3) CDHA, autogenous BMSC, and PRP. As controls served: (4) the CDHA scaffold alone and (5) the CDHA scaffold and

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Kasten, Philip, Mirjam Beverungen, Helga Lorenz, Julia Wieland, Michael Fehr, and Florian Geiger. "Comparison of Platelet-Rich Plasma and VEGF-Transfected Mesenchymal Stem Cells on Vascularization and Bone Formation in a Critical-Size Bone Defect." Karger, 2012. https://tud.qucosa.de/id/qucosa%3A27694.

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Both platelet-rich plasma (PRP) and vascular endothelial growth factor (VEGF) can promote regeneration. The aim of this study was to compare the effects of these two elements on bone formation and vascularization in combination with bone marrow stromal cells (BMSC) in a critical-size bone defect in rabbits. The critical-size defects of the radius were filled with: (1) a calcium-deficient hydroxyapatite (CDHA) scaffold + phVEGF165-transfected BMSC (VEGF group), (2) CDHA and PRP, or (3) CDHA, autogenous BMSC, and PRP. As controls served: (4) the CDHA scaffold alone and (5) the CDHA scaffold and

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Харченко, Т. О., Оксана Костянтинівна Мелеховець, Оксана Константиновна Мелеховец, Oksana Kostiantynivna Melekhovets та А. С. Радько. "Оценка качества жизни пациентов с синдромом диабетической стопы при комбинированом лечении с применением плазмотерапии". Thesis, Сумский государственный университет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/63681.

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The aim of our work is to assess the quality of life (LQ) of patients with diabetic foot syndrome with the use of plasmatherapy in combination therapy. Combined treatment of trophic ulcers with the use of plasmatherapy allows to improve the LQ of patients by 79.3%, in comparison with patients on traditional therapy, in whose LQ improved by 29.3%.<br>Celem pracy jest ocena jakości życia (LQ) pacjentów z zespołem stóp na cukrzycę z zastosowaniem plazmabrazji w leczeniu skojarzonym. Łączne leczenie wrzodów troficznych z użyciem plazmaterapii pozwala poprawić LQ przez pacjentów o 79,3%, w p

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PEIRETTI, PARADISI BENEDETTA. "Study on Coulomb explosion induced by laser-matter interaction and application to ion acceleration." Doctoral thesis, Politecnico di Torino, 2019. http://hdl.handle.net/11583/2739923.

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Lordon, de bonniol du tremont Blandine. "Etude de la perméabilisation de la membrane plasmique par spectroscopie térahertz : thérapie photodynamique et protéolyse de la trypsine." Electronic Thesis or Diss., Institut polytechnique de Paris, 2024. http://www.theses.fr/2024IPPAX073.

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Le térahertz désigne la zone de fréquence entre 0.1 et 10 THz, entre les domaines de l’infrarouge et des ondes radios. Les ondes térahertz présentent une forte sensibilité à l’eau et à ses changements de configurations, induits notamment par la présence de solutés. Bénéficiant des récents développements technologiques, la région térahertz du spectre électromagnétique offre un potentiel important dans le domaine de la biologie, et dans notre cas, du domaine biomédical.Les méthodes permettant de suivre en temps réel les échanges moléculaires à travers la membrane des cellules vivantes sont encor

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Sandri, Ana Maria. "Farmacocinetica da polimixina B intravenosa em pacientes em Unidade de Terapia Intensiva." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/88427.

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Foi realizado um estudo de farmacocinética da polimixina B em pacientes críticos com desenvolvimento de um modelo populacional. Os critérios de inclusão foram pacientes internados em Unidade de Terapia Intensiva, com idade igual ou superior a 18 anos e em uso de polimixina B intravenosa por um período mínimo de 48 horas. Amostras de sangue, urina e dialisato foram coletadas durante um intervalo de doses no estado de equilíbrio. A concentração de polimixina B no plasma foi medida por meio de cromatografia líquida de alta performance associada à espectrometria de massas acoplada à espectrometria

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Kay, Alison. "Plasmid fermentation for gene therapy and vaccination." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446856/.

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Plasmid-based gene therapy and vaccination require the production of purified plasmid DNA. There is a current understanding that supercoiled plasmid DNA is the best form for administration and FDA guidelines state that a specification for the minimum level of supercoiled plasmid DNA, in the final product, should be made. Currently, plasmids of 10 kb or smaller are being used in gene therapy trials, but if plasmid-based vaccination is to become a reality then much larger plasmids, with the ability to carry multi-variant genes, will be required, this raises questions of feasibility of production

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