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1

Jegalian, Armin G., Fabio Facchetti, and Elaine S. Jaffe. "Plasmacytoid Dendritic Cells." Advances in Anatomic Pathology 16, no. 6 (2009): 392–404. http://dx.doi.org/10.1097/pap.0b013e3181bb6bc2.

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2

Waller, Edmund K. "Mobilizing plasmacytoid dendritic cells." Blood 129, no. 19 (2017): 2600–2602. http://dx.doi.org/10.1182/blood-2017-03-774703.

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3

Maroso, Mattia. "Depleting plasmacytoid dendritic cells." Science 372, no. 6545 (2021): 929.17–929. http://dx.doi.org/10.1126/science.372.6545.929-q.

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4

Smit, Joost J., Brian D. Rudd, and Nicholas W. Lukacs. "Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus." Journal of Experimental Medicine 203, no. 5 (2006): 1153–59. http://dx.doi.org/10.1084/jem.20052359.

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Respiratory syncytial virus (RSV) infection is widely spread and is a major cause of bronchiolitis in infants and high-risk adults, often leading to hospitalization. RSV infection leads to obstruction and inflammation of the airways and induction of innate and acquired immune responses. Because dendritic cells (DCs) are essential in the elicitation of these immune responses, we investigated the presence and the role of dendritic cell subtypes upon RSV infection in the lung. Here, we report that RSV infection increased the number of both conventional and plasmacytoid dendritic cells in the lung
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5

Weslow-Schmidt, Janet L., Nancy A. Jewell, Sara E. Mertz, J. Pedro Simas, Joan E. Durbin, and Emilio Flaño. "Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection." Journal of Virology 81, no. 18 (2007): 9778–89. http://dx.doi.org/10.1128/jvi.00360-07.

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ABSTRACT The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (γHV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to γHV68. Following γHV68 intranasal inoculation, t
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6

Bardawil, Tara, Samar Khalil, Mazen Kurban, and Ossama Abbas. "Diagnostic utility of plasmacytoid dendritic cells in dermatopathology." Indian Journal of Dermatology, Venereology and Leprology 87 (February 5, 2021): 3–13. http://dx.doi.org/10.25259/ijdvl_638_19.

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Differentiating cutaneous diseases that mimic each other clinically and histopathologically can at times be a challenging task for the dermatopathologist. At the same time, differentiation of entities with overlapping features may be crucial for patient management. Although not seen in normal skin, plasmacytoid dendritic cells usually infiltrate the skin in several infectious, inflammatory/autoimmune and neoplastic entities. Plasmacytoid dendritic cells can be identified in tissue using specific markers such as CD123 and/or blood-derived dendritic cell antigen-2. Plasmacytoid dendritic cells a
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7

Tassone, Laura, Daniele Moratto, William Vermi, et al. "Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients." Blood 116, no. 23 (2010): 4870–73. http://dx.doi.org/10.1182/blood-2010-03-272096.

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Abstract Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a genetic disease that is caused by heterozygous mutations of the CXCR4 gene. These mutations confer an increased leukocyte response to the CXCR4-ligand CXCL12, resulting in abnormal homeostasis of many leukocyte types, including neutrophils and lymphocytes. Analysis of the myeloid and plasmacytoid dendritic cell blood counts in WHIM patients revealed a striking defect in the number of plasmacytoid dendritic cells as well as a partial reduction of the number of myeloid dendritic cells, compared with healthy sub
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8

Fuchsberger, Martina, Hubertus Hochrein, and Meredith O'Keeffe. "Activation of plasmacytoid dendritic cells." Immunology & Cell Biology 83, no. 5 (2005): 571–77. http://dx.doi.org/10.1111/j.1440-1711.2005.01392.x.

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9

Colonna, Marco, Giorgio Trinchieri, and Yong-Jun Liu. "Plasmacytoid dendritic cells in immunity." Nature Immunology 5, no. 12 (2004): 1219–26. http://dx.doi.org/10.1038/ni1141.

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10

Biessen, Erik A. L., and Anette Christ. "Plasmacytoid Dendritic Cells in Atherosclerosis." Circulation 130, no. 16 (2014): 1340–42. http://dx.doi.org/10.1161/circulationaha.114.012641.

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11

Okada, Tomoyuki, Zhe-Xiong Lian, Mitsuru Naiki, Aftab A Ansari, Susumu Ikehara, and M. Eric Gershwin. "Murine thymic plasmacytoid dendritic cells." European Journal of Immunology 33, no. 4 (2003): 1012–19. http://dx.doi.org/10.1002/eji.200323616.

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12

Manz, Markus G. "Plasmacytoid dendritic cells: origin matters." Nature Immunology 19, no. 7 (2018): 652–54. http://dx.doi.org/10.1038/s41590-018-0143-x.

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13

Vermi, William, Matias Soncini, Laura Melocchi, Silvano Sozzani, and Fabio Facchetti. "Plasmacytoid dendritic cells and cancer." Journal of Leukocyte Biology 90, no. 4 (2011): 681–90. http://dx.doi.org/10.1189/jlb.0411190.

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14

Bell, Elaine. "Plasmacytoid dendritic cells in psoriasis." Nature Reviews Immunology 7, no. 11 (2007): 839. http://dx.doi.org/10.1038/nri2198.

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15

Panda, Santosh K., Roland Kolbeck, and Miguel A. Sanjuan. "Plasmacytoid dendritic cells in autoimmunity." Current Opinion in Immunology 44 (February 2017): 20–25. http://dx.doi.org/10.1016/j.coi.2016.10.006.

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16

Dzionek, Andrzej, Yoshiaki Sohma, Jun Nagafune та ін. "BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction". Journal of Experimental Medicine 194, № 12 (2001): 1823–34. http://dx.doi.org/10.1084/jem.194.12.1823.

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Plasmacytoid dendritic cells are present in lymphoid and nonlymphoid tissue and contribute substantially to both innate and adaptive immunity. Recently, we have described several monoclonal antibodies that recognize a plasmacytoid dendritic cell-specific antigen, which we have termed BDCA-2. Molecular cloning of BDCA-2 revealed that BDCA-2 is a novel type II C-type lectin, which shows 50.7% sequence identity at the amino acid level to its putative murine ortholog, the murine dendritic cell–associated C-type lectin 2. Anti–BDCA-2 monoclonal antibodies are rapidly internalized and efficiently pr
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17

Baldwin, Tracey, Sandrine Henri, Joan Curtis, et al. "Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes." Infection and Immunity 72, no. 4 (2004): 1991–2001. http://dx.doi.org/10.1128/iai.72.4.1991-2001.2004.

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ABSTRACT Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger num
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18

Kaur, Varinder, Arjun Swami, Atrash Shebli, et al. "A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre-treatment with alkylating chemotherapy." Journal of Oncology Pharmacy Practice 23, no. 7 (2016): 552–56. http://dx.doi.org/10.1177/1078155216665245.

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Blastic plasmacytoid dendritic cell neoplasm is rare myeloid malignancy clinically characterized by non-pruritic, violaceous and papulo-nodular skin lesions, together with bone marrow and lymph node involvement. Histologically, there is infiltration of dermis by neoplastic mono-nuclear CD4, CD56, CD123 co-expressing cells with epidermal sparing. Most commonly blastic plasmacytoid dendritic cell neoplasm presents as a de-novo condition, and treatment-related blastic plasmacytoid dendritic cell neoplasm is a rare phenomenon. Due to rarity of the disease, there is no established standard of care
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19

Facchetti, Fabio, Marta Cigognetti, Simona Fisogni, Giuseppe Rossi, Silvia Lonardi, and William Vermi. "Neoplasms derived from plasmacytoid dendritic cells." Modern Pathology 29, no. 2 (2016): 98–111. http://dx.doi.org/10.1038/modpathol.2015.145.

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20

Hochrein, Hubertus, Meredith O’Keeffe, and Hermann Wagner. "Human and mouse plasmacytoid dendritic cells." Human Immunology 63, no. 12 (2002): 1103–10. http://dx.doi.org/10.1016/s0198-8859(02)00748-6.

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21

Galicia, Georgina, and Jennifer L. Gommerman. "Plasmacytoid dendritic cells and autoimmune inflammation." Biological Chemistry 395, no. 3 (2014): 335–46. http://dx.doi.org/10.1515/hsz-2013-0213.

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Abstract Plasmacytoid dendritic cells (pDC) are a sub-population of dendritic cells (DC) that produce large amounts of type I interferon (IFN) in response to nucleic acids that bind and activate toll-like-receptor (TLR)9 and TLR7. Type I IFN can regulate the function of B, T, DC, and natural killer (NK) cells and can also alter the residence time of leukocytes within lymph nodes. Activated pDC can also function as antigen presenting cells (APC) and have the potential to prime and differentiate T cells into regulatory or inflammatory effector cells, depending on the context. In this review we d
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22

Lande, Roberto, Valérie Gafa, Barbara Serafini, et al. "Plasmacytoid Dendritic Cells in Multiple Sclerosis." Journal of Neuropathology & Experimental Neurology 67, no. 5 (2008): 388–401. http://dx.doi.org/10.1097/nen.0b013e31816fc975.

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23

Bell, Elaine. "Terminal differentiation of plasmacytoid dendritic cells." Nature Reviews Immunology 7, no. 1 (2007): 4–5. http://dx.doi.org/10.1038/nri2009.

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24

Dargent, Jean-Louis, Pascal Vannuffel, Jean-Marie Saint-Remy, Simona Fisogni, and Fabio Facchetti. "Plasmacytoid Dendritic Cells in Kimura Disease." American Journal of Dermatopathology 31, no. 8 (2009): 854–56. http://dx.doi.org/10.1097/dad.0b013e3181a772c6.

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25

Shortman, Ken, and Priyanka Sathe. "Another Heritage for Plasmacytoid Dendritic Cells." Immunity 38, no. 5 (2013): 845–46. http://dx.doi.org/10.1016/j.immuni.2013.05.002.

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26

Goubier, Anne, Bertrand Dubois, Hanane Gheit, et al. "Plasmacytoid Dendritic Cells Mediate Oral Tolerance." Immunity 29, no. 3 (2008): 464–75. http://dx.doi.org/10.1016/j.immuni.2008.06.017.

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27

Vermi, William, Raffaella Vescovi, and Fabio Facchetti. "Plasmacytoid Dendritic Cells in Cutaneous Disorders." Current Dermatology Reports 2, no. 1 (2012): 1–10. http://dx.doi.org/10.1007/s13671-012-0033-7.

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28

Béné, Marie C., Jean Feuillard, and Marie C. Jacob. "Plasmacytoid dendritic cells: From the plasmacytoid T-cell to type 2 dendritic cells CD4+CD56+ malignancies." Seminars in Hematology 40, no. 3 (2003): 257–66. http://dx.doi.org/10.1016/s0037-1963(03)00139-2.

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29

Vermi, William, Raffaella Bonecchi, Fabio Facchetti, et al. "Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas." Journal of Pathology 200, no. 2 (2003): 255–68. http://dx.doi.org/10.1002/path.1344.

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30

Shi, Yang, and Endi Wang. "Blastic Plasmacytoid Dendritic Cell Neoplasm: A Clinicopathologic Review." Archives of Pathology & Laboratory Medicine 138, no. 4 (2014): 564–69. http://dx.doi.org/10.5858/arpa.2013-0101-rs.

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Blastic plasmacytoid dendritic cell neoplasm is a rare entity grouped with the acute myeloid leukemia–related precursor neoplasms in the 2008 World Health Organization classification. It was previously postulated to originate from natural killer cells, T cells, or monocytes but is now believed to arise from the plasmacytoid dendritic cell. The pathogenesis of blastic plasmacytoid dendritic cell neoplasm is not well understood, although the neoplasm demonstrates frequent deletion of tumor suppressor genes, including RB1, CDKN1B, CDKN2A, and TP53. Blastic plasmacytoid dendritic cell neoplasm is
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31

Crawford, Colin L., and Peter MD Hardwicke. "Plasma cells or plasmacytoid dendritic cells in sarcoidosis?" Journal of Cutaneous Pathology 42, no. 10 (2012): 789. http://dx.doi.org/10.1111/cup.12050.

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32

Pietrzak, Aldona, Konrad Janowski, Grażyna Chodorowska, et al. "Plasma Interleukin-18 and Dendritic Cells in Males with Psoriasis Vulgaris." Mediators of Inflammation 2007 (2007): 1–7. http://dx.doi.org/10.1155/2007/61254.

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Peripheral blood dendritic cells seem to play a crucial role in psoriatic inflammatory processes. The aim of our study is to investigate the relationship between plasma interleukin-18 (IL-18) levels and blood dendritic cells in psoriatic patients. IL-18 plasma levels were measured by ELISA. Phenotypes of dendritic cell subsets were analyzed by double-colour flow cytometry. Plasma IL-18 level in psoriatic males was significantly higher, whereas counts of BDCA-2+ cells were lower than in the control group. The myeloid/plasmacytoid ratio was significantly higher in the patient group compared to t
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33

SHIRASE, Haruna, Sayaka YAMAGUCHI, Kiyohito TAIRA, et al. "Two Cases of Blastic Plasmacytoid Dendritic Cell Neoplasm." Nishi Nihon Hifuka 76, no. 6 (2014): 577–82. http://dx.doi.org/10.2336/nishinihonhifu.76.577.

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34

Monti, Matilde, Francesca Consoli, Raffaella Vescovi, Mattia Bugatti, and William Vermi. "Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma." Cells 9, no. 2 (2020): 417. http://dx.doi.org/10.3390/cells9020417.

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The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has significantly improved the survival of MM patients. Notably, all these responses are highly dependent on the fitness of the host immune system, including the innate compartment. Among immune cells involved in cancer immunity, properly activated plasmacytoid dendritic cells (pDCs) exert an important role, bridging the innate and adaptive immune res
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35

Fallarino, Francesca, S. Gizzi, P. Mosci, U. Grohmann, and P. Puccetti. "Tryptophan Catabolism in IDO+ Plasmacytoid Dendritic Cells." Current Drug Metabolism 8, no. 3 (2007): 209–16. http://dx.doi.org/10.2174/138920007780362581.

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36

Hyrcza, Martin, Mario Ostrowski, and Sandy Der. "PLASMACYTOID DENDRITIC CELLS FUNCTION IN HIV INFECTION." Clinical & Investigative Medicine 31, no. 4 (2008): 13. http://dx.doi.org/10.25011/cim.v31i4.4808.

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Plasmacytoid dendritic cells (pDCs) are innate immune cells able to produce large quantities of type I interferons (IFN) when activated. Human immunodeficiency virus (HIV)-infected patients show generalized immune dysfunction characterized in part by chronic interferon response. In this study we investigated the role of dendritic cells inactivating and maintaining this response. Specifically we compared the IFN geneactivity in pDCs in response to several viruses and TLR agonists. We hypothesized that 1) the pattern of IFN gene transcription would differ in pDCs treated with HIV than with other
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37

Chairakaki, Aikaterini-Dimitra, Maria-Ioanna Saridaki, Katerina Pyrillou, et al. "Plasmacytoid dendritic cells drive acute asthma exacerbations." Journal of Allergy and Clinical Immunology 142, no. 2 (2018): 542–56. http://dx.doi.org/10.1016/j.jaci.2017.08.032.

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38

Rothenfusser, Simon, Evelyn Tuma, Stefan Endres, and Gunther Hartmann. "Plasmacytoid dendritic cells: the key to CpG." Human Immunology 63, no. 12 (2002): 1111–19. http://dx.doi.org/10.1016/s0198-8859(02)00749-8.

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39

Buckland, Jenny. "Plasmacytoid dendritic cells—perpetrators in SLE pathogenesis?" Nature Reviews Rheumatology 6, no. 10 (2010): 553. http://dx.doi.org/10.1038/nrrheum.2010.144.

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40

Al-Hage, Jana, Randa Akel, Mazen Kurban, and Ossama Abbas. "Plasmacytoid Dendritic Cells in Pityriasis Rubra Pilaris." Annals of Dermatology 31, no. 1 (2019): 87. http://dx.doi.org/10.5021/ad.2019.31.1.87.

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41

Ji, Peng, and LoAnn C. Peterson. "Plasmacytoid dendritic cells in chronic myelomonocytic leukemia." Blood 123, no. 21 (2014): 3220. http://dx.doi.org/10.1182/blood-2014-03-557587.

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42

Swiecki, Melissa, and Marco Colonna. "The multifaceted biology of plasmacytoid dendritic cells." Nature Reviews Immunology 15, no. 8 (2015): 471–85. http://dx.doi.org/10.1038/nri3865.

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43

Sorrentino, Rosalinda, Silvana Morello, and Aldo Pinto. "Plasmacytoid Dendritic Cells: From Heart to Vessels." International Journal of Vascular Medicine 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/430318.

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Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a bet
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44

Omatsu, Yoshiki, Tomonori Iyoda, Akiko Maki, et al. "Maturation and function of plasmacytoid dendritic cells." International Congress Series 1285 (November 2005): 28–33. http://dx.doi.org/10.1016/j.ics.2005.08.004.

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45

Cao, Wei, and Yong-Jun Liu. "Innate immune functions of plasmacytoid dendritic cells." Current Opinion in Immunology 19, no. 1 (2007): 24–30. http://dx.doi.org/10.1016/j.coi.2006.11.004.

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46

Hoeffel, Guillaume, Anne-Claire Ripoche, Diana Matheoud, et al. "Antigen Crosspresentation by Human Plasmacytoid Dendritic Cells." Immunity 27, no. 3 (2007): 481–92. http://dx.doi.org/10.1016/j.immuni.2007.07.021.

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47

Villadangos, José A., and Louise Young. "Antigen-Presentation Properties of Plasmacytoid Dendritic Cells." Immunity 29, no. 3 (2008): 352–61. http://dx.doi.org/10.1016/j.immuni.2008.09.002.

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48

Cao, Wei. "Molecular Characterization of Human Plasmacytoid Dendritic Cells." Journal of Clinical Immunology 29, no. 3 (2009): 257–64. http://dx.doi.org/10.1007/s10875-009-9284-x.

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49

Wang, Rui, Ju-Liang Zhang, Bo Wei, et al. "Upregulation of plasmacytoid dendritic cells in glioma." Tumor Biology 35, no. 10 (2014): 9661–66. http://dx.doi.org/10.1007/s13277-014-2211-7.

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50

Reizis, Boris. "Plasmacytoid Dendritic Cells: Development, Regulation, and Function." Immunity 50, no. 1 (2019): 37–50. http://dx.doi.org/10.1016/j.immuni.2018.12.027.

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