Relevant bibliographies by topics / Plasmalogene

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  4. Conference papers

Academic literature on the topic 'Plasmalogene'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Plasmalogene"

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Rothhaar, Tatjana L., Sven Grösgen, Viola J. Haupenthal та ін. "Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease". Scientific World Journal 2012 (2012): 1–15. http://dx.doi.org/10.1100/2012/141240.

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Lipids play an important role as risk or protective factors in Alzheimer’s disease (AD). Previously it has been shown that plasmalogens, the major brain phospholipids, are altered in AD. However, it remained unclear whether plasmalogens themselves are able to modulate amyloid precursor protein (APP) processing or if the reduced plasmalogen level is a consequence of AD. Here we identify the plasmalogens which are altered in human ADpostmortembrains and investigate their impact on APP processing resulting in Aβ production. All tested plasmalogen species showed a reduction in γ-secretase activity
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Engelmann, B. "Plasmalogens: targets for oxidants and major lipophilic antioxidants." Biochemical Society Transactions 32, no. 1 (2004): 147–50. http://dx.doi.org/10.1042/bst0320147.

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Cellular membranes and plasma lipoproteins are less efficiently protected against oxidative stress than the various aqueous compartments of mammalian organisms. Here, previous results on the role of plasmalogens in lipid oxidation are evaluated on the basis of criteria required for an antioxidant. The plasmalogen-specific enol ether double bond is targeted by a vast variety of oxidants, including peroxyl radicals, metal ions, singlet oxygen and halogenating species. Oxidation of the vinyl ether markedly prevents the oxidation of highly polyunsaturated fatty acids, and products of plasmalogen d
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Paul, Sudip, Aliki A. Rasmiena, Kevin Huynh, et al. "Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice." Metabolites 11, no. 5 (2021): 299. http://dx.doi.org/10.3390/metabo11050299.

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Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however effective modulation of different molecular plasmalogen species has not yet been demonstrated. In this study, the effects of an orally-administered AKG mix (a mixture of chimyl, batyl and selachyl alcohol at a 1:1:1 ratio) on plasma and tissue lipids, including plasmalogens, was evaluated. Mice on a
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Wu, Yue, Zhen Chen, Jiaping Jia, Hitoshi Chiba, and Shu-Ping Hui. "Quantitative and Comparative Investigation of Plasmalogen Species in Daily Foodstuffs." Foods 10, no. 1 (2021): 124. http://dx.doi.org/10.3390/foods10010124.

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Plasmalogens are an animal-derived functional phospholipid increasingly known as a safe and effective nutritional ingredient, however, the quantitation and comparison of plasmalogen species in foods is limited. In the present work, determination methods for dietary plasmalogens using liquid chromatography-tandem mass spectroscopy under positive and negative ionization modes were compared. The negative-mode method, which showed better selectivity, sensitivity, and accuracy, was then applied in 14 kinds of livestock, poultry, and seafood samples. Livestock and poultry showed abundant total plasm
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Wu, Yue, Zhen Chen, Jiaping Jia, Hitoshi Chiba, and Shu-Ping Hui. "Quantitative and Comparative Investigation of Plasmalogen Species in Daily Foodstuffs." Foods 10, no. 1 (2021): 124. http://dx.doi.org/10.3390/foods10010124.

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Plasmalogens are an animal-derived functional phospholipid increasingly known as a safe and effective nutritional ingredient, however, the quantitation and comparison of plasmalogen species in foods is limited. In the present work, determination methods for dietary plasmalogens using liquid chromatography-tandem mass spectroscopy under positive and negative ionization modes were compared. The negative-mode method, which showed better selectivity, sensitivity, and accuracy, was then applied in 14 kinds of livestock, poultry, and seafood samples. Livestock and poultry showed abundant total plasm
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Rüstow, B., I. Kolleck, F. Guthmann, R. Haupt, D. Kunze, and P. Stevens. "Synthesis and secretion of plasmalogens by type-II pneumocytes." Biochemical Journal 302, no. 3 (1994): 665–68. http://dx.doi.org/10.1042/bj3020665.

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Alveolar surfactant (exposed to air and therefore a prime target of air oxidants) is supplied with antioxidants during its intracellular formation on type-II pneumocytes [Rüstow, Haupt, Stevens and Kunze (1993) Am. J. Physiol. 265, L133-L139]. Plasmalogens can protect animal cells against lipid peroxidation caused by u.v. radiation. It has been suggested that plasmalogens play a direct role in protecting animal cell membranes against oxidative stress [Zoeller, Morand and Raetz (1988) J. Biol. Chem. 263, 11590-11596]. We investigated biosynthesis and secretion of plasmalogens and phospholipids
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Cook, Harold W., Susan E. Thomas, and Zhaolin Xu. "Essential fatty acids and serine as plasmalogen precursors in relation to competing metabolic pathways." Biochemistry and Cell Biology 69, no. 7 (1991): 475–84. http://dx.doi.org/10.1139/o91-071.

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Interest in altered ether-lipid metabolism, associated with peroxisomal disorders including adrenoleukodystrophy and Zellweger's syndrome, has highlighted present limitations in our understanding of the biosynthesis and turnover of plasmalogens. These 1-alkenyl ethanolamine phosphoglycerides are major phospholipids in brain, vascular tissue, neutrophils, and most tumors, and they constitute 15–20% of total phospholipids in cultured glioma cells. In glioma, turnover of polyunsaturated acyl chains in the sn-2 position of plasmalogens was examined in relation to selectivity for the (n–3) and (n–6
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Rüdiger, M., I. Kolleck, G. Putz, R. R. Wauer, P. Stevens, and B. Rüstow. "Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures." American Journal of Physiology-Lung Cellular and Molecular Physiology 274, no. 1 (1998): L143—L148. http://dx.doi.org/10.1152/ajplung.1998.274.1.l143.

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The alkenyl-acyl subclass of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (plasmalogens) are minor components of alveolar surfactant. Plasmalogens promote and stabilize hexagonal structures of phospholipids. In another study (W. R. Perkins, R. B. Dause, R. A. Parente, S. R. Michey, K. C. Neuman, S. M. Gruner, T. F. Taraschi, and A. S. Janoff. Science 273: 330–332, 1996), it was shown that polymorphic phase behavior may have an important role in the effective functioning of pulmonary surfactant. Therefore, we hypothesized that surface properties of phospholipid mixtures that contai
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Gallego-García, Aránzazu, Antonio J. Monera-Girona, Elena Pajares-Martínez, et al. "A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis." Science 366, no. 6461 (2019): 128–32. http://dx.doi.org/10.1126/science.aay1436.

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Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered the plasmanylethanolamine desaturase activity that is essential for vinyl ether bond formation in a bacterial enzyme, CarF, which is a homolog of the human enzyme TMEM189. CarF mediates light-induced carotenogenesis in Myxococcus xanthus, and plasmalogens participate in sensing photooxidative stress through singlet oxygen. TMEM189 and other animal homologs could functionally repl
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Werner, Ernst R., Markus A. Keller, Sabrina Sailer, et al. "TheTMEM189gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 7792–98. http://dx.doi.org/10.1073/pnas.1917461117.

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A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer’s and chronic obstructive pulmonary disease. Plasmalogens contain a characteristic 1-O-alk-1′-enyl ether (vinyl ether) double bond that confers special biophysical, biochemical, and chemical properties to these lipids. However, the genetics of their biosynthesis is not fully understood, since no gene has been identified that encodes plasmanylethanolamine desatura
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Dissertations / Theses on the topic "Plasmalogene"

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Mazzocco, Julie. "Métabolisme des plasmalogènes dans les cellules gliales rétiniennes : interactions cellule-cellule au cours du développement vasculaire rétinien normal ou pathologique." Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCI003/document.

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Dans les pays industrialisés, les pathologies oculaires à composante vasculaires, que ce soit la rétinopathie du prématuré (ROP), la rétinopathie du diabétique ou la dégénérescence lié à l’âge, représentent la première cause de cécité respectivement chez l’enfant, l’adulte et la personne âgée. Plusieurs études sur l’homme ou sur des modèles animaux ont souligné le rôle crucial joué des acides gras polyinsaturés (AGPI) au cours de ces rétinopathies et notamment l’action préventive des acides gras polyinsaturés oméga 3 (AGPI n-3) sur l’angiogenèse pathologique. Ces AGPI sont estérifiés dans les
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Schmitt, Iris Maria. "The role of plasmalogen ether lipids in the metabolic syndrome." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648371.

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Abou-Zaid, Anas Mamdouh. "On the Prevalence and Role of Addition Reactions in Lipid Peroxidation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42411.

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Plasmalogens have been reported to possess antioxidant activity; a paradoxical finding given that plasmalogens often comprise highly oxidizable polyunsaturated fatty acids esterified to the central position of the glycerol backbone. However a reasonable mechanism accounting for plasmenyl lipid activity has yet to be advanced, despite the fact that other monounsaturated lipids including cholesterol and oleate have been extensively studied. Plasmenylcholine was synthesized de novo to resolve its antioxidant activity as well as to carry out mechanistic studies to understand its basis. Autoxidatio
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Saab, Sara. "Métabolisme des plasmalogènes dans les tissus nerveux : implication dans le développement vasculaire rétinien par l'intermédiaire de la phospholipase A2 indépendante du calcium (iPLA2)." Thesis, Dijon, 2013. http://www.theses.fr/2013DIJOS028.

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Les complications vasculaires rétiniennes constituent des évènements qui peuvent être observés au cours de rétinopathies pouvant être à l’origine d’une cécité à tous les stades de la vie. Ces complications concernent particulièrement la rétinopathie du prématuré, la rétinopathie diabétique et la dégénérescence maculaire liée à l’âge. Les lipides offrent de nombreuses possibilités pour prévenir et éventuellement freiner le développement de ces rétinopathies. Parmi eux, la classe des plasmalogènes est particulièrement riche en acides gras poly-insaturés (AGPI), qui sont libérés par une phospholi
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He, Xuefei. "Pathophysiological study of the effects of plasmalogen deficiency on ATII cell surfactant protein secretion." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110507.

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Past studies suggest that the primary cause of death in patients with the peroxisome disease, rhizomelic chondrodysplasia punctata (RCDP), may be due to lung dysfunction. In our laboratory, we have evaluated the RCDP equivalent mouse model, the Pex7 hypomorphic mouse, and found that it shows abnormal lung morphology, which coincides with the cause of death. However, the pathophysiology of this pulmonary dysfunction still remains unknown. RCDP is an autosomal recessive disease that involves PEX7 gene mutations. The PEX7 gene encodes a transporter protein that is essential for plasmalogen synth
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Luoma, Adrienne M. "The Effects of Reactive Oxygen Species on Internodal Myelin Structure, and Role of Plasmalogen Phospholipids as Endogenous Antioxidants." Thesis, Boston College, 2009. http://hdl.handle.net/2345/1943.

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Thesis advisor: Daniel A. Kirschner<br>Reactive oxygen species (ROS) are implicated in a range of degenerative conditions, including aging, neurodegenerative diseases, and neurological disorders such as multiple sclerosis. Myelin is a lipid-rich multilamellar assembly that facilitates rapid nerve conduction in higher animals, and may be intrinsically vulnerable to oxidative damage given the high energetic demands and low antioxidant capacity of myelinating cells. To determine whether ROS can cause structural damage to internodal myelin, whole mouse sciatic and optic nerves were incubated ex vi
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Nadeau, Jordan. "Les plasmalogènes comme traitement prophylactique dans la maladie de Parkinson au niveau intestinal." Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/30258.

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La phase avancée de la maladie de Parkinson (MP) caractérisée par des symptômes moteurs est souvent précédée par des troubles gastro-intestinaux qui proviendraient d'une altération des neurones dopaminergiques (DAergiques) de l’intestin. Des études suggèrent que la maladie se propagerait au cerveau via le nerf vague. Notre laboratoire a démontré le rôle majeur de l’inflammation dans l’intestin chez des souris parkinsoniennes. Récemment, une baisse des niveaux de plasmalogènes, des glycérophospholipides, dans le cerveau et le sang de patients parkinsoniens a été rapportée. Les plasmalogènes ave
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Calhoon, Elisabeth Ann. "Lipids of mitochondria in fibroblasts and their nexus to life history in temperate and tropical birds." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306866847.

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Sibomana, Isaie. "Evidence That Myo-Inositol Plus Ethanolamine Elevates Plasmalogen Levels And Lends Protection Against Oxidative Stress In Neuro-2A Cells." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484661880801698.

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André, Agnès. "Approche du métabolisme des plasmalogènes cérébraux : influences du vieillissement et des acides gras alimentaires n-3." Dijon, 2005. http://www.theses.fr/2005DIJOMU10.

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Le cerveau, riche en plasmalogènes, est particulièrement affecté par le vieillissement. Ces phospholipides, réservoirs d'acides gras polyinsaturés et antioxydants potentiels, subissent des modifications avec l'âge. Nos travaux ont montré une augmentation de leurs teneurs dans le cerveau de rat en début de vie corrélée à une forte activité à 3 mois de la DHAP-AT. La diminution des teneurs en plasmalogènes avec l'âge est associée à une augmentation de l'activité de la PLA2 spécifique des plasmalogènes (Pls-PLA2). Les teneurs en aldéhydes et α-hydroxyaldéhydes, produits de dégradation oxydative d
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Book chapters on the topic "Plasmalogene"

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Hoffmann, G. F., C. D. Langhans, and A. Schulze. "Plasmalogene." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2456.

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Hoffmann, G. F., C. D. Langhans, and A. Schulze. "Plasmalogene." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2456-1.

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Schomburg, Dietmar, and Dörte Stephan. "Plasmalogen synthase." In Enzyme Handbook 11. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61030-1_157.

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Hossain, Md Shamim, Shiro Mawatari, and Takehiko Fujino. "Biological Functions of Plasmalogens." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-60204-8_13.

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Hossain, Md Shamim, Shiro Mawatari, and Takehiko Fujino. "Biological Functions of Plasmalogens." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-60204-8_13.

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Farooqui, Akhlaq A., Wei-Yi Ong, and Lloyd A. Horrocks. "Plasmalogens, Docosahexaenoic Acid and Neurological Disorders." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9072-3_45.

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Honsho, Masanori, and Yukio Fujiki. "Analysis of Plasmalogen Synthesis in Cultured Cells." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6937-1_6.

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Anderson, Valerie C., and David H. Thompson. "Photoinduced Morphological Changes in Plasmalogen Liposomes Using Visible Light." In ACS Symposium Series. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0493.ch014.

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Yang, Hsiu-Chiung, Akhlaq A. Farooqui, and Lloyd A. Horrocks. "Characterization of Plasmalogen-Selective Phospholipase A2 from Bovine Brain." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0179-8_49.

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Scherrer, Linda A., and Richard W. Gross. "Subcellular distribution, molecular dynamics and catabolism of plasmalogens in myocardium." In Lipid Metabolism in Normoxic and Ischemic Heart. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1611-4_15.

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Conference papers on the topic "Plasmalogene"

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Sordillo, J., S. M. Lutz, R. S. Kelly, et al. "Plasmalogens Mediate Age-Related Changes in Bronchodilator Response for Individuals with Asthma." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1267.

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Denisenko, Y., T. Novgorodtseva, E. Ermolenko, et al. "Blood Plasma Molecular Species of Ethanolamine Plasmalogens in Asthma Complicated with Obesity." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4320.

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Sturk, A., M. C. L. Schaap, A. Prins Heymans, et al. "SEVERELY IMPAIRED SYNTHESIS OF PLATELET ACTIVATING FACTOR IN CHONDRO DYSPLASIA PUNCTATA RHIZOMELIA PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642883.

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The first steps of the de novo synthesis of alkoxyether lipids, like plasmalogens and platelet activating factor (PAF) are localized in the peroxisome. We have previously reported the severely impaired PAF synthesis in Zellweger patients. These patients lack cytochemically detectable peroxisomes, and have a severely impaired alkoxyether lipid synthesis. However, chondro dysplasia punctata (CDP) patients have also been shown to have an impaired alkoxyether lipid synthesis. We therefore investigated PAF synthesis in CDP patients.Platelets and leucocytes were isolated from 3 CDP patients. Leucocy
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