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Dissertations / Theses on the topic 'Plasminogen activator inhibitor type-1'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Sancho, Elena. "Conformation and activity of plasminogen activator inhibitor type 1 (PAI-1)." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU552562.

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Plasminogen activator inhibitor type 1 (PAI-1) is a unique member of the serpins in that it can adopt various conformations. It is synthesized as an active inhibitor which rapidly converts to a latent form that is not inhibitory. Conformational studies on this protein have been made difficult by this property. The production of recombinant PAI-1 was studied. The expression of r-PAI-1 by the bacterial strain MSD 1005 accounted for some 15-20% of the total cell protein, although some was produced in the form of inclusion bodies. As an attempt to improve the yields of PAI-1 antigen and activity,

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2

Alotaibi, Fahad T. "Plasminogen activator inhibitor-1 in endometriosis." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59961.

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Endometriosis is a disease that affects almost 10% of reproductive-age women, where 50 % of these women have pelvic pain with sexual intercourse. Deep endometriosis is defined as an endometriotic lesion penetrating to a depth of 5 mm or more, and is characterized by both fibrosis (forming nodules) and invasion (into structures such as the colon). Other groups have found that increased plasminogen activator inhibitor-1 (PAI-1) or (SERPINE1) expression was associated with fibrosis and tumor invasion. In addition, a previous study found that the SERPINE1 4G allele (and thus increased gene express

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3

Dawson, Sally. "Genetic variation at the plasminogen activator inhibitor-1 locus and its effect on plasminogen activator inhibitor-1 expression." Thesis, Imperial College London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298676.

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4

Panahloo, Archia. "Plasminogen activator inhibitor-1 and cardiovascular risk." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286442.

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5

Sui, Guang-Chao. "Structure-function studies of plasminogen activator inhibitor-1 /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3255-7/.

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6

Tierney, Marcus John 1973. "Post-transcriptional regulation of plasminogen activator inhibitor type 2." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8496.

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7

Miyazaki, Hiroshi. "Studies on Inhibitors of Plasminogen Activator Inhibitor-1(PAI-1) and Inhibitors of PAI-1 Production as Antithrombotic Agents." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/126818.

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8

Byberg, Liisa. "Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5307-4/.

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9

Dickinson, Joanne L. "The regulation and function of plasminogen activator inhibitor type 2 /." [St Lucia, Qld.], 1995. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18712.pdf.

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10

Kendziora, Elena Stephanie [Verfasser], Viktor [Akademischer Betreuer] Magdolen, Wilko [Gutachter] Weichert, and Viktor [Gutachter] Magdolen. "Analysis of Urokinase-type Plasminogen Activator (uPA), Plasminogen Activator Inhibitor Type-1 (PAI-1), and Urokinase Plasminogen Activator Receptor (uPAR) Protein Expression by Immunohistochemistry in Triple-Negative Breast Cancer (TNBC) / Elena Stephanie Kendziora ; Gutachter: Wilko Weichert, Viktor Magdolen ; Betreuer: Viktor Magdolen." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1208325000/34.

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11

Lobov, Sergei. "Plasminogen activator inhibitor type 2 : a unique serpin with two mobile loops." Doctoral thesis, Umeå : Department of Medical Biochemistry and Biophysics, Umeå University, Sweden, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223.

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12

Hasenstab, David R. "Animal models of atherosclerosis : overexpression of plasminogen activator inhibitor type 1 (PAI-1) and tissue factor in the rat carotid artery /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6315.

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13

Sharp, Allan Murray. "Structural studies of active plasminogen activator inhibitor-1 and Shiga-like toxin-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0011/NQ60020.pdf.

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14

Creighton, Ruth Isobel. "Physiological effects of producing plasminogen activator inhibitor-1 (PAI-1) in Escherichia coli." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245253.

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The effect of producing human plasminogen activator inhibitor-1 (PAI-1) on the physiology of the bacterium <I>Escherichia coli </I>has been investigated. PAI-1 belongs to the family of serine protease inhibitors. These inhibitors are distinct from others in that they contain the active site bond located on a mobile loop. A plasmid containing the <I>PAI-1 </I>gene was used to accumulate PAI-1 to 20% of the total cell protein. At least 50% of PAI-1 was accumulated as the active soluble protein. PAI-1 production has been shown to decrease the growth rate from 0.76 ± 0.038 h<SUP>-1</SUP> (n = 4) t

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15

Sundell-Rånby, Birgitta. "Food intake, fibrinolysis and risk factors for cardiovascular disease : studies with special focus on plasminogen activator inhibitor type 1 (PAI-1)." Doctoral thesis, Umeå universitet, Patologi, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101290.

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Elevated plasminogen activator inhibitor (PAI-1) activity levels, hyperlipemia, hypertension, impaired glucose tolerance and obesity, in particular central obesity, are all related to increased risk for the development of cardiovascular disease.Some risk factors are known to be and shown to be influenced by dietary habits. One aim of this study was to determine the distribution of PAI-1 activity and its linkage to serum lipids, body build, glucose and insulin (including glucose tolerance) among healthy men and women. Another aim was to elucidate the effects of different diet programes on the r

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16

Hägglöf, Peter. "Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements /." Umeå : Umeå University, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177.

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17

Hägglöf, Peter. "Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements." Doctoral thesis, Umeå University, Medical Biochemistry and Biophsyics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177.

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<p>Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. The specificity of a serpin is determined by the Pl-Pl’ peptide bond acting as a bait for the target protease which is made up of an exposed reactive centre loop (RCL). The serpin plasminogen activator inhibitor type-1 (PAI-1) is the main physiological inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA, resp

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18

North, Christina Johanna. "Effect of dietary fibre on selected haemostatic variables and C-reactive protein / Christina Johanna North." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1417.

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Motivation: Cardiovascular heart disease (CVD) is the leading cause of death worldwide. Risk markers for CVD include, amongst others, the haemostatic factors tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), factor VII (FVII) and fibrinogen and more recently, C-reactive protein (CRP), a sensitive marker of inflammation. Epidemiological studies have demonstrated an inverse association between dietary fibre (DF) consumption and risk factors for CVD and CVD prevalence. Some research indicates that this protection may be related to favourable changes in the

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19

Bauerfeind, Ursula Katharina [Verfasser], Jürgen [Akademischer Betreuer] Dittmer, and Matthias [Akademischer Betreuer] Dürst. "Einfluss von Biopsie-, Aufarbeitungs- und Asservierungsbedingungen auf den Nachweis von urokinase type plasminogen activator (uPA) und plasminogen activator inhibitor-1 (PAI-1) beim Mammakarzinom / Ursula Katharina Bauerfeind. Betreuer: Jürgen Dittmer ; Matthias Dürst." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024874478/34.

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20

Nordenhem, Arvid. "The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-560-7/.

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21

Lafargue, Mathieu. "Plasminogen Activator Inhibitor-1 (PAI-1) and Activated Protein C (aPC) Modulation Mechanisms of Pseudomonas aeruginosa Induced Pulmonary Edema." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22020/document.

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Une coagulopathie aigue endogène (EAC) est présente chez 25% des patients de traumatologie dès leur arrivée. Des résultats d’études récentes montrent que cette EAC est liée à l’activation de la voie de la protéine C (aPC). Quelques heures après, se développe un état pro-coagulant associant un niveau abaissé d’aPC et un taux plasmatique élevé de l’inhibiteur de l’activateur du plasminogene (PAI-1). Nous trouvons que l’incidence des pneumopathies associées à la ventilation est significativement augmentée chez ces patients sans toutefois connaître le rôle exact de ces anomalies de coagulation. Ba

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22

Grimsley, Philip George Medical Sciences Faculty of Medicine UNSW. "Receptor mediated catabolism of plasminogen activators." Awarded By:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/44489.

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Humans have two plasminogen activators (PAs), tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which generate plasmin to breakdown fibrin and other barriers to cell migration. Both PAs are used as pharmaceuticals but their efficacies are limited by their rapid clearance from the circulation, predominantly by parenchymal cells of the liver. At the commencement of the work presented here, the hepatic receptors responsible for mediating the catabolism of the PAs were little understood. tPA degradation by hepatic cell lines was known to depend on the forma

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23

Hertig, Alexandre. "Rôle de l'inhibiteur de type 1 des activateurs du plasminogène dans la régulation de la fibrinolyse glomérulaire : application au modèle de glomérulonéphrite par anticorps anti-membrane basale glomérulaire." Paris 6, 2004. http://www.theses.fr/2004PA066590.

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24

Nilsson, Lennart. "Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3443-6/.

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25

Billström, Anita. "The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2." Lund : Research Laboratory, Dept. of Obstetrics and Gynaecology, Lund University Hospital, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751812.html.

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26

Gamble, Joanne. "Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/17373/.

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Energy homeostasis is a tightly regulated system that is vital for survival involving anorectic and orexigenic signals. Obesity is a maladaptive response where the balance becomes disrupted. Obesity is one of the most concerning health problems of our time. It is no longer considered a consequence of a western lifestyle, with more developing countries now reporting an increased incidence of obesity and associated illnesses. While obesity itself can be debilitating and decrease quality of life, it is the associated comorbidities that are the main cause for concern; including type two diabetes,

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27

Palmer, Iolanthe Marike. "The association of uric acid and plasminogen activator inhibitor-1 (PAI-1) with cardiovascular function in South African women : the POWIRS-study / I.M. Palmer." Thesis, North-West University, 2006. http://hdl.handle.net/10394/117.

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Motivation: Hypertension is a fast growing health risk, leading to increased incidences of cardiovascular dysfunction and mortality. However, the prevalence of hypertension is higher in some ethnic populations than others. Several South African studies have found that the African population is more susceptible to the development of hypertension, compared to the Caucasian population. Cardiovascular dysfunction is often accompanied by elevated levels of uric acid (UA) and plasminogen activator inhibitor-I (PAI-1) and both are factors associated with the metabolic syndrome. A lack of data regardi

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28

Schrötzlmair, Florian Albert Johann [Verfasser], Achim [Akademischer Betreuer] Krüger, Manfred [Akademischer Betreuer] Schmitt, and Jürgen [Akademischer Betreuer] Schlegel. "Urokinase-type plasminogen activator (uPA) als Mediator der durch tissue inhibitor of metalloproteinases-1 (TIMP-1) induzierten Lebermetastasierung / Florian Schrötzlmair. Gutachter: Achim Krüger ; Manfred Schmitt ; Jürgen Schlegel. Betreuer: Achim Krüger." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1014330343/34.

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29

Libraire, Julie. "Le facteur 4 plaquettaire (PF4/CXCL4) prévient la formation du complexe initial de l’inhibiteur de l’activateur du plasminogène (PAI-1) avec sa cible d’origine tissulaire (t-PA)." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P654.

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Le facteur 4 plaquettaire (PF4/CXCL4) est un tétramère constitué de quatre sous-unités identiques de 7,8 kDa qui est libéré en grande quantité par les plaquettes lors de l’hémostase primaire (ensemble des phénomènes permettant un colmatage initial d’une lésion vasculaire). L’étude de la formation d’un caillot de fibrine en présence de PF4 montre une augmentation de la turbidité finale du caillot : le PF4 modifie le réseau formé. Etant donné que la plupart des acteurs de la fibrinolyse se lie au caillot de fibrine et que le PF4 modifie sa structure, nous avons pensé qu’il serait intéressant de

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30

Wiklund, Per-Gunnar. "Genetic aspects of stroke : association and linkage studies in a northern Swedish population." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-668.

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31

Novotny, Ann. "Aspects of Non-Neuronal Signalling Functions of Acetylcholine in Colorectal Cancer : Roles for the α7nAChR". Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2348.

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32

Nienaber, Cornelie. "Haemostatic variables in African adolescents : the PLAY study / Cornelie Nienaber." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1322.

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33

Katre, Ashwini A. "Ozone and lung fibrosis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009m/katre.pdf.

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34

Milliat, Fabien. "Rôle de l'endothélium dans les dommages radio-induits aux tissus sains." Paris 6, 2007. http://www.theses.fr/2007PA066077.

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L’objectif de la radiothérapie est de délivrer à la tumeur une dose d’irradiation maximale tout en préservant l’intégrité des tissus sains adjacents. Cependant, la toxicité radio-induite aux tissus sains est un facteur limitant dans l’escalade de dose pouvant être délivrée à la tumeur et constitue un problème clinique majeur. Ainsi, la compréhension des mécanismes moléculaires et cellulaires associés aux dommages radio-induits est indispensable dans l’objectif de mettre en place des stratégies thérapeutiques visant à protéger les tissus sains sans compromettre et même améliorer le contrôle tum

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35

Biljana, Vučković. "Poremećaj funkcionalnosti fibrinoliznog mehanizma kod bolesnika sa venskom trombozom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=87834&source=NDLTD&language=en.

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Tromboza danas, u većini razvijenih zemalja, predstavlja vodeći uzrok obolevanja i umiranja. Poslednjih godina veoma aktuelna su istraživanja venskog tromboembolizma, obzirom da je incidenca ovog oboljenja 2/1000 osoba godi&scaron;nje, a njegov razvoj posledica udruženog delovanja vi&scaron;e genetskih i stečenih faktora rizika. &Scaron;to preciznije prepoznavanje i sagledavanje &scaron;to većeg broja ovih faktora osnovni je cilj u borbi, kako protiv prve epizode venske tromboze, tako i protiv recidiva ove bolesti. Brojni faktori rizika već su prepoznati kao sastavne karike patofiziolo&scaron;

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36

Kanuri, Giridhar [Verfasser], and Stephan C. [Akademischer Betreuer] Bischoff. "Role of plasminogen activator inhibitor (PAI-1) in the pathogenesis of fructose-induced non-alcoholic fatty liver disease (NAFLD) / Giridhar Kanuri. Betreuer: Stephan C. Bischoff." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2012. http://d-nb.info/1027354297/34.

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37

Meade, Eliza. "Hypoxic Regulation of VEGF and PAI-1 Expression by HIF-1[alpha] and HIF-2[alpha] in First Trimester Trophoblasts." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-115727/.

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Preeclampsia results from incomplete trophoblast invasion of the spiral arteries during early pregnancy. Vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) are critical factors involved in angiogenesis, invasion and hemostasis at the maternal-fetal interface. Both factors are transcriptionally regulated by hypoxia inducible factor (HIF), a heterodimeric complex consisting of HIF-1[beta] and either HIF-1[alpha] or -2[alpha] whose specificity or redundancy in gene regulation is cell-type specific. This study uses siRNA technology to dissect the mechanisms of

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38

Agarwal, Udit. "Factors Affecting Ventricular Remodeling Post Myocardial Infarction." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1269627876.

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39

Freese, Christiane. "Rolle der Plasmakonzentrationen von transforming growth factor-[beta]1 [factor-beta1] (TGF[beta]1) [TGF beta 1], Tumor necrosis factor [alpha] [Tumor necrosis factor alpha] (TNF [alpha]) [TNF alpha] und Plasminogen-Activator-Inhibitor-(PAI-)-Antigen bei Patienten mit Diabetes Mellitus Typ 2 und koronarer Herzkrankheit." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=97149200X.

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40

Machado, Glória Beatriz da Silva. "Atividade pró-trombótica da toxina ExoU de Pseudomonas aeruginosa detectada em modelos experimentais in vivo e in vitro." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3492.

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Pseudomonas aeruginosa é um importante agente de pneumonia, particularmente em pacientes submetidos à ventilação mecânica, que pode evoluir para sepse, com elevadas taxas de letalidade. Na sepse, o processo inflamatório sistêmico exacerbado favorece o desequilíbrio entre as vias de coagulação e fibrinólise e a instalação de um estado pró-coagulante, com o aparecimento de trombose microvascular, coagulação intravascular disseminada e falência de múltiplos órgãos. Conhecendo a potente atividade pró-inflamatória da toxina ExoU produzida por P. aeruginosa, decorrente de sua atividade fosfolipásica

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OLIVEIRA, Georgge Gomes. "Polimorfismo da região -675 do gene serpine1 (polimorfismo 4g5g) e sua associação com inibidor 1 da ativação do plasminogenio (pai-1), síndrome metabólica e risco cardiovascular em pessoas vivendo com hiv/aids: um estudo caso-controle aninhado à coorte." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/18083.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-12-15T14:53:15Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) VersaoAtualizada2016 - Tese Georgge Gomes Oliveira - varsão para biblioteca UFPE.pdf: 3290385 bytes, checksum: 2ddc23c4486bcc121a9ea222566d1f09 (MD5)<br>Made available in DSpace on 2016-12-15T14:53:15Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) VersaoAtualizada2016 - Tese Georgge Gomes Oliveira - varsão para biblioteca UFPE.pdf: 3290385 bytes, checksum: 2ddc23c4486

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Silva, Thaís Girão da. "Mecanismos moleculares envolvidos no fenótipo endotelial em resposta a estímulos físicos e químicos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-22102018-104726/.

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O endotélio reveste a parede vascular e possui função essencial na manutenção da homeostase. A célula endotelial é capaz de perceber estímulos extracelulares, como fatores químicos e mecânicos, transmitir a informação para dentro da célula e regular sua função e fenótipo. Neste sentido, investigamos os mecanismos moleculares associados as células endoteliais em dois contextos importantes de intervenções vasculares 1) nos stents farmacológicos, onde a rapamicina exerce funções antiproliferativas e pró-trombogênicas, e 2) na revascularização cardíaca por ponte de safena, onde o alto estiramento

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43

Sharmin, Nahid. "Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension". Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17177.

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Vascular remodelling due to excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left untreated. Heterozygous germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 gene impinge upon the BMP signalling which perturbs

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44

ALESSI, GILBERT MARIE-CHRISTINE. "Contribution a l'etude de l'inhibiteur antiactivateur du plasminogene de type 1 (p. A. I. -1) : etude de la repartition des formes moleculaires de cet inhibiteur dans le plasma ; relation inhibiteur - insuline." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20067.

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45

COLOMBIES, BRIGITTE. "Influence de l'insulinotherapie et de la dietetique sur les taux de pai-1 chez les diabetiques de type 2." Toulouse 3, 1993. http://www.theses.fr/1993TOU31126.

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46

Reid, Fiona Jane. "Plasminogen activators and their inhibitor synthesized by human mesangial cells and other cell types." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU539471.

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The plasminogen activator synthesized by human mesangial cells was identified as tissue-type plasminogen activator (t-PA). Glomerular epithelial cells synthesized t-PA and urokinase (u-PA). Both mesangial cells and glomerular epithelial cells synthesized plasminogen activator inhibitor-1 (PAI-1) into culture supernatant. In this study experimental techniques were developed to allow quantification of matrix-associated PAI-1. PAI-1 associated with the matrix of mesangial cells was less than 1% of the total PAI-1 synthesized by the cells. Similar amounts were detected in the matrix of human umbil

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Rouch, Anne. "Recherche d'agents pro-fibrinolytiques : conception, synthèse et études biologiques de nouveaux inhibiteurs de la formation du complexe PAI-1-tPA." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/4418/.

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Abstract:

Le système fibrinolytique est responsable de la dissolution de la fibrine contenue dans les caillots sanguins. Parmi tous les acteurs de ce système, les activateurs du plasminogène de type tissulaire (tPA) et de type urokinase (uPA) sont particulièrement importants. Ils permettent de convertir le plasminogène en plasmine à la surface de la fibrine. La plasmine dégrade ensuite la fibrine en produits de dégradation solubles permettant la recanalisation des vaisseaux occlus. Le principal inhibiteur endogène de tPA/uPA est l'activateur des inhibiteurs du plasminogène de type 1 (PAI-1), une protéin

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AVEROUS, VERONIQUE. "Diabete non insulinodependant et inhibiteur antiactivateur du plasminogene (pai-1) : revue de la litterature et evaluation des variations postprandiales." Reims, 1992. http://www.theses.fr/1992REIMM083.

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Lopez, Sophie. "Etude de la synthese de l'inhibiteur des activateurs du plasminogene de type 1 (pai-1) : sa regulation au cours de la differenciation monocytaire et sa modulation pharmacologique par les statines (doctorat : nutrition)." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20665.

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Morange, Pierre-Emmanuel. "Etude de la synthèse de l'inhibiteur des activateurs du plasminogène de type 1 (PAI-1) , facteur d'athérothrombose, par le tissu adipeux." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20673.

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