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Dissertations / Theses on the topic 'Plasminogen activator inhibitor type I (PAI-1)'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Sancho, Elena. "Conformation and activity of plasminogen activator inhibitor type 1 (PAI-1)." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU552562.

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Plasminogen activator inhibitor type 1 (PAI-1) is a unique member of the serpins in that it can adopt various conformations. It is synthesized as an active inhibitor which rapidly converts to a latent form that is not inhibitory. Conformational studies on this protein have been made difficult by this property. The production of recombinant PAI-1 was studied. The expression of r-PAI-1 by the bacterial strain MSD 1005 accounted for some 15-20% of the total cell protein, although some was produced in the form of inclusion bodies. As an attempt to improve the yields of PAI-1 antigen and activity,

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2

Hasenstab, David R. "Animal models of atherosclerosis : overexpression of plasminogen activator inhibitor type 1 (PAI-1) and tissue factor in the rat carotid artery /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6315.

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3

Sundell-Rånby, Birgitta. "Food intake, fibrinolysis and risk factors for cardiovascular disease : studies with special focus on plasminogen activator inhibitor type 1 (PAI-1)." Doctoral thesis, Umeå universitet, Patologi, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101290.

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Elevated plasminogen activator inhibitor (PAI-1) activity levels, hyperlipemia, hypertension, impaired glucose tolerance and obesity, in particular central obesity, are all related to increased risk for the development of cardiovascular disease.Some risk factors are known to be and shown to be influenced by dietary habits. One aim of this study was to determine the distribution of PAI-1 activity and its linkage to serum lipids, body build, glucose and insulin (including glucose tolerance) among healthy men and women. Another aim was to elucidate the effects of different diet programes on the r

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4

Kendziora, Elena Stephanie [Verfasser], Viktor [Akademischer Betreuer] Magdolen, Wilko [Gutachter] Weichert, and Viktor [Gutachter] Magdolen. "Analysis of Urokinase-type Plasminogen Activator (uPA), Plasminogen Activator Inhibitor Type-1 (PAI-1), and Urokinase Plasminogen Activator Receptor (uPAR) Protein Expression by Immunohistochemistry in Triple-Negative Breast Cancer (TNBC) / Elena Stephanie Kendziora ; Gutachter: Wilko Weichert, Viktor Magdolen ; Betreuer: Viktor Magdolen." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1208325000/34.

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5

Hägglöf, Peter. "Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements." Doctoral thesis, Umeå University, Medical Biochemistry and Biophsyics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177.

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<p>Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. The specificity of a serpin is determined by the Pl-Pl’ peptide bond acting as a bait for the target protease which is made up of an exposed reactive centre loop (RCL). The serpin plasminogen activator inhibitor type-1 (PAI-1) is the main physiological inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA, resp

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6

Bauerfeind, Ursula Katharina [Verfasser], Jürgen [Akademischer Betreuer] Dittmer, and Matthias [Akademischer Betreuer] Dürst. "Einfluss von Biopsie-, Aufarbeitungs- und Asservierungsbedingungen auf den Nachweis von urokinase type plasminogen activator (uPA) und plasminogen activator inhibitor-1 (PAI-1) beim Mammakarzinom / Ursula Katharina Bauerfeind. Betreuer: Jürgen Dittmer ; Matthias Dürst." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024874478/34.

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7

Billström, Anita. "The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2." Lund : Research Laboratory, Dept. of Obstetrics and Gynaecology, Lund University Hospital, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751812.html.

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8

Hertig, Alexandre. "Rôle de l'inhibiteur de type 1 des activateurs du plasminogène dans la régulation de la fibrinolyse glomérulaire : application au modèle de glomérulonéphrite par anticorps anti-membrane basale glomérulaire." Paris 6, 2004. http://www.theses.fr/2004PA066590.

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9

Hägglöf, Peter. "Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements /." Umeå : Umeå University, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177.

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10

North, Christina Johanna. "Effect of dietary fibre on selected haemostatic variables and C-reactive protein / Christina Johanna North." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1417.

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Motivation: Cardiovascular heart disease (CVD) is the leading cause of death worldwide. Risk markers for CVD include, amongst others, the haemostatic factors tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), factor VII (FVII) and fibrinogen and more recently, C-reactive protein (CRP), a sensitive marker of inflammation. Epidemiological studies have demonstrated an inverse association between dietary fibre (DF) consumption and risk factors for CVD and CVD prevalence. Some research indicates that this protection may be related to favourable changes in the

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11

Grimsley, Philip George Medical Sciences Faculty of Medicine UNSW. "Receptor mediated catabolism of plasminogen activators." Awarded By:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/44489.

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Humans have two plasminogen activators (PAs), tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which generate plasmin to breakdown fibrin and other barriers to cell migration. Both PAs are used as pharmaceuticals but their efficacies are limited by their rapid clearance from the circulation, predominantly by parenchymal cells of the liver. At the commencement of the work presented here, the hepatic receptors responsible for mediating the catabolism of the PAs were little understood. tPA degradation by hepatic cell lines was known to depend on the forma

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12

Libraire, Julie. "Le facteur 4 plaquettaire (PF4/CXCL4) prévient la formation du complexe initial de l’inhibiteur de l’activateur du plasminogène (PAI-1) avec sa cible d’origine tissulaire (t-PA)." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P654.

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Le facteur 4 plaquettaire (PF4/CXCL4) est un tétramère constitué de quatre sous-unités identiques de 7,8 kDa qui est libéré en grande quantité par les plaquettes lors de l’hémostase primaire (ensemble des phénomènes permettant un colmatage initial d’une lésion vasculaire). L’étude de la formation d’un caillot de fibrine en présence de PF4 montre une augmentation de la turbidité finale du caillot : le PF4 modifie le réseau formé. Etant donné que la plupart des acteurs de la fibrinolyse se lie au caillot de fibrine et que le PF4 modifie sa structure, nous avons pensé qu’il serait intéressant de

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13

Milliat, Fabien. "Rôle de l'endothélium dans les dommages radio-induits aux tissus sains." Paris 6, 2007. http://www.theses.fr/2007PA066077.

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L’objectif de la radiothérapie est de délivrer à la tumeur une dose d’irradiation maximale tout en préservant l’intégrité des tissus sains adjacents. Cependant, la toxicité radio-induite aux tissus sains est un facteur limitant dans l’escalade de dose pouvant être délivrée à la tumeur et constitue un problème clinique majeur. Ainsi, la compréhension des mécanismes moléculaires et cellulaires associés aux dommages radio-induits est indispensable dans l’objectif de mettre en place des stratégies thérapeutiques visant à protéger les tissus sains sans compromettre et même améliorer le contrôle tum

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Machado, Glória Beatriz da Silva. "Atividade pró-trombótica da toxina ExoU de Pseudomonas aeruginosa detectada em modelos experimentais in vivo e in vitro." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3492.

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Pseudomonas aeruginosa é um importante agente de pneumonia, particularmente em pacientes submetidos à ventilação mecânica, que pode evoluir para sepse, com elevadas taxas de letalidade. Na sepse, o processo inflamatório sistêmico exacerbado favorece o desequilíbrio entre as vias de coagulação e fibrinólise e a instalação de um estado pró-coagulante, com o aparecimento de trombose microvascular, coagulação intravascular disseminada e falência de múltiplos órgãos. Conhecendo a potente atividade pró-inflamatória da toxina ExoU produzida por P. aeruginosa, decorrente de sua atividade fosfolipásica

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15

Schrötzlmair, Florian Albert Johann [Verfasser], Achim [Akademischer Betreuer] Krüger, Manfred [Akademischer Betreuer] Schmitt, and Jürgen [Akademischer Betreuer] Schlegel. "Urokinase-type plasminogen activator (uPA) als Mediator der durch tissue inhibitor of metalloproteinases-1 (TIMP-1) induzierten Lebermetastasierung / Florian Schrötzlmair. Gutachter: Achim Krüger ; Manfred Schmitt ; Jürgen Schlegel. Betreuer: Achim Krüger." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1014330343/34.

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16

Wiklund, Per-Gunnar. "Genetic aspects of stroke : association and linkage studies in a northern Swedish population." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-668.

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17

Freese, Christiane. "Rolle der Plasmakonzentrationen von transforming growth factor-[beta]1 [factor-beta1] (TGF[beta]1) [TGF beta 1], Tumor necrosis factor [alpha] [Tumor necrosis factor alpha] (TNF [alpha]) [TNF alpha] und Plasminogen-Activator-Inhibitor-(PAI-)-Antigen bei Patienten mit Diabetes Mellitus Typ 2 und koronarer Herzkrankheit." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=97149200X.

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18

Nienaber, Cornelie. "Haemostatic variables in African adolescents : the PLAY study / Cornelie Nienaber." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1322.

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19

Miyazaki, Hiroshi. "Studies on Inhibitors of Plasminogen Activator Inhibitor-1(PAI-1) and Inhibitors of PAI-1 Production as Antithrombotic Agents." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/126818.

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20

Creighton, Ruth Isobel. "Physiological effects of producing plasminogen activator inhibitor-1 (PAI-1) in Escherichia coli." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245253.

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The effect of producing human plasminogen activator inhibitor-1 (PAI-1) on the physiology of the bacterium <I>Escherichia coli </I>has been investigated. PAI-1 belongs to the family of serine protease inhibitors. These inhibitors are distinct from others in that they contain the active site bond located on a mobile loop. A plasmid containing the <I>PAI-1 </I>gene was used to accumulate PAI-1 to 20% of the total cell protein. At least 50% of PAI-1 was accumulated as the active soluble protein. PAI-1 production has been shown to decrease the growth rate from 0.76 ± 0.038 h<SUP>-1</SUP> (n = 4) t

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21

Byberg, Liisa. "Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5307-4/.

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22

Lafargue, Mathieu. "Plasminogen Activator Inhibitor-1 (PAI-1) and Activated Protein C (aPC) Modulation Mechanisms of Pseudomonas aeruginosa Induced Pulmonary Edema." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22020/document.

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Une coagulopathie aigue endogène (EAC) est présente chez 25% des patients de traumatologie dès leur arrivée. Des résultats d’études récentes montrent que cette EAC est liée à l’activation de la voie de la protéine C (aPC). Quelques heures après, se développe un état pro-coagulant associant un niveau abaissé d’aPC et un taux plasmatique élevé de l’inhibiteur de l’activateur du plasminogene (PAI-1). Nous trouvons que l’incidence des pneumopathies associées à la ventilation est significativement augmentée chez ces patients sans toutefois connaître le rôle exact de ces anomalies de coagulation. Ba

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23

COLOMBIES, BRIGITTE. "Influence de l'insulinotherapie et de la dietetique sur les taux de pai-1 chez les diabetiques de type 2." Toulouse 3, 1993. http://www.theses.fr/1993TOU31126.

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24

Gamble, Joanne. "Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/17373/.

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Energy homeostasis is a tightly regulated system that is vital for survival involving anorectic and orexigenic signals. Obesity is a maladaptive response where the balance becomes disrupted. Obesity is one of the most concerning health problems of our time. It is no longer considered a consequence of a western lifestyle, with more developing countries now reporting an increased incidence of obesity and associated illnesses. While obesity itself can be debilitating and decrease quality of life, it is the associated comorbidities that are the main cause for concern; including type two diabetes,

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25

Palmer, Iolanthe Marike. "The association of uric acid and plasminogen activator inhibitor-1 (PAI-1) with cardiovascular function in South African women : the POWIRS-study / I.M. Palmer." Thesis, North-West University, 2006. http://hdl.handle.net/10394/117.

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Motivation: Hypertension is a fast growing health risk, leading to increased incidences of cardiovascular dysfunction and mortality. However, the prevalence of hypertension is higher in some ethnic populations than others. Several South African studies have found that the African population is more susceptible to the development of hypertension, compared to the Caucasian population. Cardiovascular dysfunction is often accompanied by elevated levels of uric acid (UA) and plasminogen activator inhibitor-I (PAI-1) and both are factors associated with the metabolic syndrome. A lack of data regardi

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Rouch, Anne. "Recherche d'agents pro-fibrinolytiques : conception, synthèse et études biologiques de nouveaux inhibiteurs de la formation du complexe PAI-1-tPA." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/4418/.

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Le système fibrinolytique est responsable de la dissolution de la fibrine contenue dans les caillots sanguins. Parmi tous les acteurs de ce système, les activateurs du plasminogène de type tissulaire (tPA) et de type urokinase (uPA) sont particulièrement importants. Ils permettent de convertir le plasminogène en plasmine à la surface de la fibrine. La plasmine dégrade ensuite la fibrine en produits de dégradation solubles permettant la recanalisation des vaisseaux occlus. Le principal inhibiteur endogène de tPA/uPA est l'activateur des inhibiteurs du plasminogène de type 1 (PAI-1), une protéin

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Kanuri, Giridhar [Verfasser], and Stephan C. [Akademischer Betreuer] Bischoff. "Role of plasminogen activator inhibitor (PAI-1) in the pathogenesis of fructose-induced non-alcoholic fatty liver disease (NAFLD) / Giridhar Kanuri. Betreuer: Stephan C. Bischoff." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2012. http://d-nb.info/1027354297/34.

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Morange, Pierre-Emmanuel. "Etude de la synthèse de l'inhibiteur des activateurs du plasminogène de type 1 (PAI-1) , facteur d'athérothrombose, par le tissu adipeux." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20673.

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ALESSI, GILBERT MARIE-CHRISTINE. "Contribution a l'etude de l'inhibiteur antiactivateur du plasminogene de type 1 (p. A. I. -1) : etude de la repartition des formes moleculaires de cet inhibiteur dans le plasma ; relation inhibiteur - insuline." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20067.

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Party, Helene. "Rôle de l'inhibiteur de l'activateur tissulaire du plasminogène de type 1 (PAI-1) dans la dépression majeure chez la souris." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMC411.

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La dépression majeure représente l’une des affections les plus lourdes dans le monde, touchant plus de 350 millions depersonnes. La 5e édition du Diagnostic and Statistical Manual of Mental Disorders (DSM-V) est la référence mondiale utiliséepour poser le diagnostic de la pathologie chez l’humain. Bien que très nombreux, les antidépresseurs prescrits à ce jour restentencore malheureusement inefficaces pour 30% des patients. Dans ce contexte, il est fondamental de développer de nouvellesstratégies thérapeutiques pour soigner les patients. Des études récentes suggèrent, sans toutefois le démontr

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Lopez, Sophie. "Etude de la synthese de l'inhibiteur des activateurs du plasminogene de type 1 (pai-1) : sa regulation au cours de la differenciation monocytaire et sa modulation pharmacologique par les statines (doctorat : nutrition)." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX20665.

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Meade, Eliza. "Hypoxic Regulation of VEGF and PAI-1 Expression by HIF-1[alpha] and HIF-2[alpha] in First Trimester Trophoblasts." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-115727/.

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Preeclampsia results from incomplete trophoblast invasion of the spiral arteries during early pregnancy. Vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) are critical factors involved in angiogenesis, invasion and hemostasis at the maternal-fetal interface. Both factors are transcriptionally regulated by hypoxia inducible factor (HIF), a heterodimeric complex consisting of HIF-1[beta] and either HIF-1[alpha] or -2[alpha] whose specificity or redundancy in gene regulation is cell-type specific. This study uses siRNA technology to dissect the mechanisms of

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OLIVEIRA, Georgge Gomes. "Polimorfismo da região -675 do gene serpine1 (polimorfismo 4g5g) e sua associação com inibidor 1 da ativação do plasminogenio (pai-1), síndrome metabólica e risco cardiovascular em pessoas vivendo com hiv/aids: um estudo caso-controle aninhado à coorte." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/18083.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-12-15T14:53:15Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) VersaoAtualizada2016 - Tese Georgge Gomes Oliveira - varsão para biblioteca UFPE.pdf: 3290385 bytes, checksum: 2ddc23c4486bcc121a9ea222566d1f09 (MD5)<br>Made available in DSpace on 2016-12-15T14:53:15Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) VersaoAtualizada2016 - Tese Georgge Gomes Oliveira - varsão para biblioteca UFPE.pdf: 3290385 bytes, checksum: 2ddc23c4486

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Sharmin, Nahid. "Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension". Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17177.

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Vascular remodelling due to excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left untreated. Heterozygous germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 gene impinge upon the BMP signalling which perturbs

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Xu, Jia-Jun, and 許佳君. "Biosynthesis and regulation of plasminogen activator inhibitor type 1 (PAI=1) in endothelial cell (HUVEC)." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/89010931487096167311.

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Biermann, Julia [Verfasser]. "Quantification of urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) mRNA in breast cancer tissue / Julia Christina Biermann." 2009. http://d-nb.info/999935976/34.

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Schröck, Florian Rudolf [Verfasser]. "Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin : characterization of different PAI-1 mutants / Florian Rudolf Schröck." 2005. http://d-nb.info/97417047X/34.

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Hsu, Chia-Chun, and 許佳君. "Biosynthesis and Regulation of Plasminogen Activator Inhibitor Type I (PAI-1) in Endothelial Cell(HUVEC)." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/61622577380497501791.

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碩士<br>國立成功大學<br>生物化學研究所<br>82<br>In order to study the regulation of the PAI-1 biosynthesis in endothelial cells, we investigated the effect of t-PA on the expression mRNA and antigen of PAI-1 in cultured human　 umbilical vein endothelial cells (HUVEC). The endothelial cells 　were treated with t-PA at 37oC for 30 min and then total RNA 　was isolated at different time intervals, and subjected to　 northern blot analysis. The PAI-1 mRNA expressed in endothelial 　cells was stimulated by t-PA

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Li, Shih-Hon. "Insights into the dynamic structure and inhibitory mechanism of plasminogen activator inhibitor type 1 /." 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337878.

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Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 2008.<br>Source: Dissertation Abstracts International, Volume: 69-11, Section: B, page: 6774. Adviser: Bradford S. Schwartz. Includes bibliographical references (leaves 130-145). Available on microfilm from Pro Quest Information and Learning.

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Cook, P. Michael. "A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade." Thesis, 2008. http://hdl.handle.net/1974/1014.

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Previous work has shown that thrombin activatable fibrinolysis inhibitor (TAFI) was unable to prolong lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis to circumvent prolongation mediated by activated TAFI (TAFIa). Therefore, the effects of TAFIa on Lys-Pg activation and Lys-plasmin (Lys-Pn) inhibition by antiplasmin (AP) were quantitatively investigated using a fluorescently labeled recombinant Pg mutant which does not produce active Pn. High molecular weight fibrin degradation products (HMW-FDPs), a soluble fibrin surrogat

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North, C. J. (Christina Johanna). "Effect of dietary fibre on selected haemostatic variables and C-reactive protein / C.J. North." Thesis, 2006. http://hdl.handle.net/10394/1417.

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Brown, Cynthia Lee. "Characterization of Vitronectin and Plasminogen Activator Inhibitor Type 1: Insights into Metal Binding, and Production of Reagents to Facilitate Structural Studies." 2008. http://etd.utk.edu/2008/December2008MastersTheses/BrownCynthiaLee.pdf.

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Freese, Christiane [Verfasser]. "Rolle der Plasmakonzentrationen von transforming growth factor-β1 [factor-beta1] (TGFβ1) [TGF beta 1], {Tumor necrosis factor α [Tumor necrosis factor alpha] {(TNF α) [TNF alpha] und Plasminogen-Activator-Inhibitor-(PAI-)-Antigen bei Patienten mit Diabetes Mellitus Typ 2 und koronarer Herzkrankheit / vorglegt von Christiane Freese". 2002. http://d-nb.info/97149200X/34.

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Dimova, Elitsa Yosifova. "Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-AB9F-7.

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Goswami, Sumit. "Studies on the Role of Vitronectin and Plasminogen-Activator Inhibitor-1 Complexes Beyond Inhibiting Proteases: Binding to the Extracellular Matrix, Cell Interactions and Pathogenesis." 2010. http://trace.tennessee.edu/utk_graddiss/800.

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Abstract:

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily of proteins, circulates in blood in a complex with vitronectin (VN). These two proteins are also found localized together in the extracellular matrix in many different pathophysiological conditions. Both of these proteins are involved with a number of physiologically important processes. Though PAI-1 is a well-known inhibitor of serine proteases, more emphasis is now geared towards its protease independent functions. VN, on the other hand, is a binding protein that exists in the circulatio

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Wang, Chaung-Fu, and 王長富. "Evaluating the Roles of Inflammatory Mediators, Matrix Metalloproteinase-9(MMP-9), Glutathione Peroxidase(GPx) and Plasminogen Activator Inhibitor-1(PAI-1) between Periodontal Disease and Cardiovascular Disease." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/59007171440892168900.

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Abstract:

碩士<br>高雄醫學大學<br>牙醫學研究所碩士班<br>95<br>Objectives: Studies have proved that periodontitis is a typical inflammatory disease and cardiovascular disease (CVD) is influenced by inflammatory factors of these diseases. Previous studies have suggested the relationships between CVD and periodontitits. Some inflammatory biomarkers, such as MMP-9, PAI-1 and GPx of periodontitis were found to have important influences both on periodontitis and CVD. The definite relations of these markers between them were not found. As a result, the purpose of this study is to find the difference of these three biomarker be

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