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Dissertations / Theses on the topic 'Plasmodium falciparum. Malaria Antimalarials. Malariotherapy'

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Published: 4 June 2021

Last updated: 16 February 2022

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1

Botha, Maria Magdalena. "Structure-based inhibitor design and validation : application to Plasmodium falciparum glutathione S-transferase." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-07212008-140458/.

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2

Birkholtz, Lyn-Marie. "Functional and structural characterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-06302005-120320/.

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3

Van, Brummelen Anna Catharina. "Functional genomics analysis of the effects of co-inhibition of the malarial S-adenosylmethionine decarboxylase/ornithine decarboxylase." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-05302009-124548.

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4

Human, Esmaré. "Kinetic analysis of a recombinantly expressed Plasmodium falciparum dihydrofolate synthase-folylpolyglutamate synthase." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-06252008-093616/.

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Thesis (MSc Natural and Agricultural Sciences (Biochemistry))-University of Pretoria, 2007.<br>Summary in English and Afrikaans. Includes bibliographical references. Available on the Internet via the World Wide Web.

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Birkholtz, Lyn-Marie. "Functional and structural charaterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Thesis, University of Pretoria, 2001. http://hdl.handle.net/2263/25944.

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Malaria remains one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapies. The need for novel therapeutic targets and drugs is therefore of the utmost importance and detailed knowledge of the biochemistry of the parasite is imperative. This study was directed at the biochemical characterisation of the polyamine metabolic pathway of P. falciparum in order to elucidate differences between the parasite and its human host that can be exploited in the design of novel antim

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6

Dhoogra, Minishca. "Gene expression profiling of polyamine-depleted Plasmodium falciparum." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-12132007-103643/.

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7

Kayano, Ana Carolina Andrade Vitor 1984. "Avaliação in vivo e in vitro da atividade antimalárica de Caesalpinia pluviosa e análise da fração ativa." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316725.

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Orientador: Fabio Trindade Maranhão Costa<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T14:00:00Z (GMT). No. of bitstreams: 1 Kayano_AnaCarolinaAndradeVitor_M.pdf: 4619978 bytes, checksum: 3bf657caae96f9c4faf7fcdf7e519956 (MD5) Previous issue date: 2011<br>Resumo: Para superar o problema do aumento de resistência às drogas, os medicamentos tradicionais são fontes importantes na investigação de potenciais novos antimaláricos. Caesalpinia pluviosa, mais conhecida como 'sibipiruna', é originária do Brasil e estudos

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8

Gupta, Seema. "Experimental pharmacodynamic and kinetic studies related to new combination therapies against falciparum malaria /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-066-4/.

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9

Yao, Jia. "Synthesis of silver nanoparticles and their role against a thiazolekinase enzyme from Plasmodium falciparum." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020894.

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Malaria, a mosquito-borne infectious disease, caused by the protozoan Plasmodium genus, is the greatest health challenges worldwide. The plasmodial vitamin B1 biosynthetic enzyme PfThzK diverges significantly, both structurally and functionally from its counterpart in higher eukaryotes, thereby making it particularly attractive as a biomedical target. In the present study, PfThzK was recombinantly produced as 6×His fusion protein in E. coli BL21, purified using nickel affinity chromatography and size exclusion chromatography resulting in 1.03% yield and specific activity 0.28 U/mg. The enzyme

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10

Ursing, Johan. "Plasmodium Falciparum response to chloroquine and artemisinin based combination therapy (Act) in Guinea Bissau." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-695-8/.

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11

Walker, Dawn Marie. "The Study of Autophagy in Plasmodium falciparum." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385586661.

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12

Njuguna, Joyce Njoki. "Structural analysis of prodomain inhibition of cysteine proteases in plasmodium species." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004081.

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Plasmodium is a genus of parasites causing malaria, a virulent protozoan infection in humans resulting in over a million deaths annually. Treatment of malaria is increasingly limited by parasite resistance to available drugs. Hence, there is a need to identify new drug targets and authenticate antimalarial compounds that act on these targets. A relatively new therapeutic approach targets proteolytic enzymes responsible for parasite‟s invasion, rupture and hemoglobin degradation at the erythrocytic stage of infection. Cysteine proteases (CPs) are essential for these crucial roles in the intraer

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13

Goble, Jessica Leigh. "The druggable antimalarial target 1-deoxy-D-xylulose-5-phosphate reductoisomerase: purfication, kinetic characterization and inhibition studies." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004008.

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Plasmodium falciparum 1–deoxy–D–xylulose–5 phosphatereductoisomerase (PfDXR) plays a role in isoprenoid biosynthesis in the malaria parasite and is absent in the human host, making this parasite enzyme an attractive target for antimalarial drug design. To characterize PfDXR, it is necessary to produce large quantities of the enzyme in a soluble and functional form. However, the over–production of malarial proteins in prokaryotic host systems often results in the formation of truncated proteins or insoluble protein aggregates. A heterologous expression system was developed for the production of

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14

Abrahams, Meryl Arlene. "Bioassay-guided fractionation of Artemisia afra for in vitro antimalarial activity against Plasmodium falciparum." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26263.

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With the increase in recent years in the prevalence of malaria, and in drug resistance of Plasmodium falciparum, there has been much interest in natural plant products for new antimalarials with novel modes of action against Plasmodium. Artemisinin or Qinghaosu is one such antimalarial isolated from a Chinese herb, Anemisia annua (Asteraceae) and it is currently undergoing phase I and II clinical trials. The Southern African species, Artemisia afra (African wormwood, wildeals, lengana) is commonly used by local traditional healers for symptoms of malaria, in particular fever. Thus it seemed ap

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15

Silva, Márcia Ferreira da. "Estudos in vitro de potenciais antimaláricos nos estágios intraeritrocítico de Plasmodium falciparum." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-23042013-122652/.

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Nesta dissertação, identificou-se que as drogas esqualestatina, fosmidomicina, risedronato e nerolidol apresentam atividades sinérgicas e aditivas quando administradas em cultura de P. falciparum. Esses resultados contribuem para a compreensão da biologia do parasita e abrem estudos para possíveis antimaláricos. Identificou-se a especificidade da droga esqualestatina inibidora da enzima fitoeno sintase por meio de marcações metabólicas utilizando precursor radioativo ([3H]GGPP), e análise pela técnica de cromatografia (RP-HPLC). Realizou-se testes de inibição para determinar o valor da IC50 na

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16

Okell, Lucy C. "Modelling the impact of artemisinin combination therapies (ACT) and alternative antimalarials on transmission intensity of Plasmodium falciparum malaria." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536879.

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17

Sussmann, Rodrigo Antonio Ceschini. "Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-05082011-105023/.

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O estudo da biossíntese de isoprenóides em P. falciparum por meio da via 2C-metil-D-eritritol-4-fosfato (MEP) é apontado como possível alvo terapêutico, visto a via ser ausente em humanos. Foi descrito que nos estágios intraeritrocitários de P. falciparum a via essencial de biossíntese de isoprenóides é a via MEP. As vias do Chiquimato e MEP são precursoras da biossíntese de vitamina E e ambas já foram descritas em P. falciparum. É sugerido que a biossíntese de vitamina E possa ocorrer no parasita, representando um possível alvo para o desenvolvimento de novas drogas antimaláricas. Empregando

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18

Alvarado, Stephenie M. "Identification of novel antimalarials from marine natural products for lead discovery." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4591.

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An estimated 500 million cases of malaria occur each year. The increasing prevalence of drug resistant strains of Plasmodium in most malaria endemic areas has significantly reduced the efficacy of current antimalarial drugs for prophylaxis and treatment of this disease. Therefore, discovery of new, inexpensive, and effective drugs are urgently needed to combat this disease. Marine biodiversity is an enormous source of novel chemical entities and has been barely investigated for antimalarial drug discovery. In an effort to discover novel therapeutics for malaria, we studied the antimalarial act

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19

Cockburn, Ingrid Louise. "Modulation of Plasmodium falciparum chaperones PfHsp70-1 and PfHsp70-x by small molecules." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1001747.

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The heat shock proteins of ~ 70 kDa (Hsp70s) are a conserved group of molecular chaperones important in maintaining the protein homeostasis in cells, carrying out functions including refolding of misfolded or unfolded proteins. Hsp70s function in conjunction with a number of other proteins including Hsp40 cochaperones. Central to the regulation Hsp70 activity is the Hsp70 ATPase cycle, involving ATP hydrolysis by Hsp70, and stimulation of this ATP hydrolysis by Hsp40. PfHsp70-1, the major cytosolic Hsp70 in the malaria parasite, Plasmodium falciparum, and PfHsp70-x, a novel malarial Hsp70 rece

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20

Schuck, Desirée Cigaran. "Novos compostos sintéticos com ação no ciclo de vida de parasitas da malária humana, Plasmodium falciparum." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-19032014-170035/.

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Apesar dos esforços mundiais a malária ainda é uma doença com altas taxas de morbidade e mortalidade. Investigamos o efeito de moléculas sintéticas relacionadas a melatonina e a triptamina no ciclo celular de P. falciparum, bem como mostramos que essa classe de compostos apresenta ação antimalárica significativa. Avaliamos também 5 novas hidroxinaftoquinonas sintéticas em cultura in vitro de P. falciparum, todas apresentaram atividade antimalárica, tendo N3 destacado-se por apresentar um IC50 na faixa nanomolar. Mostramos que o possível mecanismo de ação de N3 é inibindo o potencial de membran

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21

Mokoena, Fortunate. "Malarial drug targets cysteine proteases as hemoglobinases." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004065.

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Malaria has consistently been rated as the worst parasitic disease in the world. This disease affects an estimated 5 billion households annually. Malaria has a high mortality rate leading to distorted socio-economic development of the world at large. The major challenge pertaining to malaria is its continuous and rapid spread together with the emergence of drug resistance in Plasmodium species (vector agent of the disease). For this reason, researchers throughout the world are following new leads for possible drug targets and therefore, investigating ways of curbing the spread of the disease.

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22

Liebman, Katherine May. "New 4-Aminoquinoline Compounds to Reverse Drug Resistance in P. falciparum Malaria, and a Survey of Early European Antimalarial Treatments." PDXScholar, 2014. http://pdxscholar.library.pdx.edu/open_access_etds/2114.

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Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity agains

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23

Khan, Tasmiyah. "Development of a novel, quantitative assay for determining the rate of activity of antimalarial drugs." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1001618.

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Malaria, caused by an intracellular Plasmodium parasite, remains a devastating disease, having claimed approximately 655 000 lives worldwide in 2010. The Medicines for Malaria Venture suggests a "single-dose radical cure" as the ideal malaria treatment since rapid clearance of blood-stage parasites and symptom relief improves patient compliance and limits drug resistance. Thus, novel antimalarials should be rapid-acting and assessing their rate of activity is critical to drug discovery. Traditional evaluation of this rate by morphological assessments is flawed by highly subjective, operator-sp

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24

Sussmann, Rodrigo Antonio Ceschini. "Estudo da função de vitamina E e da biossíntese de vitamina K1 em Plasmodium falciparum." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-23122015-084842/.

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A malária apresenta um alto índice de mortalidade com mais de 500 mil mortes registradas em 2013. Para agravar a situação de saúde pública, foi descrito o surgimento de resistência às drogas usadas na terapêutica da doença. Torna-se necessário a identificação e o estudo de novos alvos antimaláricos. A via MEP se mostra como um potencial alvo para o desenvolvimento de drogas contra P. falciparum uma vez que está ausente em humanos. Nossos objetivos foram avaliar a função da vitamina E biossintetizada pelo parasita, caracterizar a biossíntese de vitamina K1 e o metabolismo de fitol. Esse estudo

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25

Inoue, Juliana. "Marcadores moleculares para análise do polimorfismo genético relacionado à resposta de Plasmodium falciparum aos antimaláricos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-27082014-114248/.

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A malária é responsável por cerca de 207 milhões de casos e 627 mil óbitos em todo o mundo. No Brasil, em 2013, foram registrados mais de 167 mil casos. Um dos grandes desafios para o controle da doença é o desenvolvimento de resistência aos antimaláricos. Dentre as cinco espécies que podem causar malária em seres humanos, Plasmodium falciparum é a que apresenta maior habilidade de desenvolver resistência a quase todas as classes de medicamentos utilizados no tratamento. Estudos com marcadores moleculares têm associado mutações em diversos genes à resistência aos antimaláricos. A mutação K76T

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26

Vargas-Rodriguez, Rosa Del Carmen Miluska. "Comportamento de Plasmodium falciparum frente aos esquemas terapêuticos de primeira linha para malária: avaliação da sensibilidade in vitro e do mecanismo de dormência das terapias combinadas com artemisinina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-08032017-163039/.

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A caracterização fenotípica de Plasmodium falciparum permite conhecer o padrão de sensibilidade do parasito às drogas antimaláricas utilizadas em países endêmicos. No presente estudo avaliamos fenotipicamente isolados clínicos de P. falciparum provenientes do Continente Africano e do Caribe. A sensibilidade à dihidroartemisinina (DHA: 4 - 1.000 nM), artesunato (AS: 0,1 - 100 nM), lumefantrina (LMF: 3,1 - 200 nM) e mefloquina (MFQ: 0,2 - 1.000 nM) foi investigada por meio de quatro técnicas: (a) ensaio de sensibilidade ex-vivo e in vitro, (b) ensaio de dormência, (c) ensaio de citometria de flu

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27

Kanzi, Aquillah Mumo. "Falcipains as malarial drug targets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1003842.

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Malaria is an infectious disease caused by parasites of the Plasmodium genus with mortality rates of more than a million annually, hence a major global public health concern. Plasmodium falciparum (P. falciparum) accounts for over 90% of malaria incidence. Increased resistance to antimalarial drugs by the Plasmodium parasite, coupled with the lack of an effective malaria vaccine necessitates the urgent need for new research avenues to develop novel and more potent antimalarial drugs. This study focused on falcipains, a group of P. falciparum cysteine proteases that belong to the clan CA and pa

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28

Mutorwa, Marius Kudumo. "Synthesis of novel inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase as potential anti-malarial lead compounds." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1005037.

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This research has focused on the development of novel substrate mimics as potential DXR inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an essential enzyme in the mevalonate-independent pathway for the biosynthesis of isoprenoids in Plasmodium falciparum. DXR mediates the isomerisation and reduction of 1-deoxy-D-xylulose-5-phosphate (DOXP) into 2C-methyl-D-erithrytol 4-phosphate (MEP) and has been validated as an attractive target for the development of novel anti-malarial chemotherapeutic agents. Reaction of various amines with specially prepared 4-phosphonated crotonic a

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Marques, Joana. "Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/359656.

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Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. The clinical, social and economic burden of malaria has led to several waves of serious efforts to reach its control and eventual eradication, without success to this day. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial dru

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Garavito, Giovanny. "Etude pharmacologique expérimentale de l'activité antipaludique d'un composé de synthèse : le chlorure de methylthioninium." Phd thesis, Université Paul Sabatier - Toulouse III, 2007. http://tel.archives-ouvertes.fr/tel-00639025.

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Nous nous sommes intéressés à l'activité antipaludique du bleu de méthylène (BM), qui fut la première molécule de synthèse utilisée dans le traitement des accès palustres. Nous avons montré que le BM est actif sur des souches cultivées de Plasmodium falciparum d'origines géographiques et de chloroquino-sensibilités différentes (CI50<10nM). Il est aussi actif sur le cycle sanguin de Plasmodium murin (DE50<15mg/Kg), mais pas sur la phase hépatique. Les stades érythrocytaires les plus sensibles sont les stades jeunes. Les associations avec les traitements classiques sont de type : antagoniste ave

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Steyn, Denise. "Mechanisms of potential novel antimalarials and proteomics of Plasmodium falciparum resistance." Diss., 2016. http://hdl.handle.net/2263/51382.

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Introduction: Plasmodium falciparum is the dominant cause of severe malaria in humans, with the highest number of global deaths occurring in Africa and Southeast Asia. Even though artemisinin-derivative combination therapies are readily available in Africa there are numerous reports of poor quality products which may lead to the development of drug resistance in Plasmodium parasites. Other aspects such as counterfeit medicines with sub-therapeutic levels of active ingredients may also be a contributing factor. The exact mechanism of P. falciparum drug resistance is still poorly understood, but

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Stokes, Barbara. "Examining the role of K13 in artemisinin-resistant Plasmodium falciparum malaria." Thesis, 2020. https://doi.org/10.7916/d8-t7gf-x240.

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Despite the concerted efforts of researchers, policy makers and public health workers worldwide, malaria persists as a significant disease threat for nearly half the world’s population. Recent advances in vector control measures, diagnostics and antimalarial drug therapies have contributed greatly to reducing the incidence of clinical disease, and by extension, the number of deaths attributable to malaria in the past two decades; however, the latter remains high—over 400,000 people die each year from malaria, the vast majority of these being children under the age of five. Our ability to rapid

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Coetzee, Linda. "Plasmodium falciparum dihydrofolate synthase (DHFS-FPGS) : gene synthesis and recombinant expression." Diss., 2004. http://hdl.handle.net/2263/24333.

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Malaria causes nearly 3 million deaths annually. The parasite species responsible for the most lethal forms of malaria is P. falciparum (Miller et.al., 2002). Its destructive effect is most evident in the developing African countries, which lack the infrastructure and financial support to effectively control the disease. The only viable means of control at this stage is the use of antimalarial chemotherapy and –prophylaxis, but these drugs are losing their effectivity due to parasite resistance. This underlines the need for new, safe, efficient and cheap drugs as a solution to the African mala

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Murithi, James Muriungi. "Dissecting the mechanisms of antiplasmodial resistance in Plasmodium falciparum." Thesis, 2021. https://doi.org/10.7916/d8-n6ja-7e15.

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The strides made in malaria eradication efforts have been aided by a combination of vector control and chemoprevention. However, Plasmodium resistance to ﬁrst-line artemisinin-based combination therapies (ACTs), and mosquito resistance to insecticides threatens the progress made. Innovative vector control measures, vaccines and antimalarial drugs with novel modes of action are key to disease eradication. High-throughput phenotypic screening of chemical libraries tested directly against all the stages of the Plasmodium lifecycle have been the mainstay of antimalarial drug discovery eff

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Wells, Gordon Andreas. "Structural model and properties of AdoMetDc domain of the bifunctional Plasmodium falciparum S-adenosylmethionine decarboxylase/Ornithine decarboxylase." Diss., 2004. http://hdl.handle.net/2263/24336.

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Hiltunen, Tamara Ann. "Elemental composition in monocytes in response to anti-malarial drugs and hemozoin." Thesis, 2003. http://hdl.handle.net/10413/10154.

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Every year there are approximately 300 million new cases of malaria with 2 million deaths. The majority of deaths occur in African children between the ages of 1 and 4 years and are caused by the parasite Plasmodium falciparum. Approximately R90-million is spent by the South African government each year to control malaria. Peripheral blood monocytes are the first line of defence during infection and they perform many functions, such as phagocytosis, intracellular and extracellular killing by the generation of reactive oxygen intermediates and the production of cytokines. During malaria infecti

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Makumire, Stanley. "Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop." Thesis, 2019. http://hdl.handle.net/11602/1436.

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PhD (Biochemistry)<br>Department of Biochemistry<br>The main malaria agent, Plasmodium falciparum expresses an Hsp70 (PfHsp70-1) which plays a significant role in parasite survival. PfHsp70-1 is distinct in that it possesses glycine-glycine-methionine-proline (GGMP) tetrapeptide repeats in its C-terminal domain. To date, the GGMP motif of PfHsp70-1 has not been studied. The motif is positioned within the C-terminal lid segment of PfHsp70-1. The motif is also about seven residues upstream the terminal EEVD residues that are responsible for the interaction of PfHsp70-1 with its functional regula

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Kim, Jonathan Young. "Structural Investigation of Plasmodium falciparum Chloroquine Resistance Transporter in the Context of Anti-Malarial Drug Resistance." Thesis, 2019. https://doi.org/10.7916/d8-c5s0-ff42.

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Malaria is a mosquito borne infectious disease caused by a unicellular Apicomplexan parasite of the Plasmodia genus. The emergence and subsequent spread of drug resistance in the highly virulent Plasmodium falciparum parasite has been a major setback in eradicating malaria, which affects an estimated 216 million individuals and causes 445,000 deaths annually worldwide. Chloroquine (CQ) was once used as the first-line antimalarial drug treatment, until CQ-resistant parasites emerged in endemic regions including Africa, Southeast Asia, and South America. More recently, parasites have developed r

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Zani, Babalwa. "The efficacy and safety of artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in non-pregnant adults and children : a systematic review." Thesis, 2011. http://hdl.handle.net/10413/10009.

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Effective case management of malaria is hampered by the spread of parasite resistance to nonartemisinin antimalarials. To counteract the impact of drug resistance, the World Health Organization (WHO) has endorsed artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated Plasmodium falciparum malaria. Currently recommended ACTs are artemether-lumefantrine, artesunate plus amodiaquine, artesunate plus mefloquine, artesunate plus sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine. This study sought to review evidence of the efficacy and safety of differen

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"The study on the 42kda carboxyl terminal fragment of plasmodium falciparum merozoite surface protein 1 (Pfmsp-1-42) and its processing fragments for candidate antigen of malarial vaccine." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074345.

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In the second part of the project, the immunology of PfMSP-133 was studied. During the invasion of merozoites, PfMSP--142 is processed into two fragments with molecular weight of 33kDa and 19kDa. The 19kDa fragment (PfMSP-119) originating from the carboxyl--terminal of PfMSP--142 is relatively more immuno-dominant in different malarial species such as P. falciparum, P. vivax and P. yoelii. In the past, only limited researches about PfMSP-1 33 were performed. Apart from its difficulty in expression, PfMSP-1 33 was also believed to be incapable of inducing protection.<br>Nevertheless, following

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41

Tsoka, Joyce Mahlako. "Effect of pyrimethamine on gametocytogenesis, exflagellation and asexual growth in southern African isolates of Plasmodium Falciparum." Thesis, 1995. http://hdl.handle.net/10413/10341.

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Pyrimethamine efficacy was investigated in vitro on the blood asexual stages, the sexual stages and exflagellation in Plasmodium falciparum. Gametocytogenesis was stimulated following the standard methods on five isolates of Plasmodium falciparum. From these five isolates, RSA 2, 3 and 5 produced gametocytes which reached maturity within seven days and the gametocytes were able to exflagellate. Isolate MW2 produced young gametocytes which disappeared within ten days. NF54 produced mature gametocytes which lasted for 24 hours only. There were no statistically significant differences between the

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42

"Expression of a hexa-histidine tagged Plasmodium falciparum merozoite surface protein-1 C-terminal processing fragment (C-HisPfMSP-1₄₂) in silkworm larvae using bombyx mori nuclear polyhedrosis virus." 2002. http://library.cuhk.edu.hk/record=b5891302.

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Chan Ping Kei.<br>Thesis submitted in: December 2001.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (leaves 135-143).<br>Abstracts in English and Chinese.<br>ACKNOWLEGEMENTS --- p.i<br>ABSTRACT --- p.ii<br>TABLE OF CONTECTS --- p.v<br>LIST OF FIGURE --- p.viii<br>LIST OF ABBREVIATIONS --- p.xii<br>CHAPTER<br>Chapter 1 --- INTRODUCTION<br>Chapter 1.1 --- Epidemilogy --- p.1<br>Chapter 1.2 --- Malaria disease --- p.1<br>Chapter 1.3 --- Life cycle of Malaria --- p.1<br>Chapter 1.4 --- Current measure to control Malaria --- p.6<br>Chapt

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Sharma, Shilpi. "Components Of Fatty Acid Synthesis In Plasmodium Falciparum." Thesis, 2006. http://hdl.handle.net/2005/380.

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The disease malaria afflicts more than a billion people and kills almost one to three million of them every year. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, Plasmodium falciparum is the deadliest as it causes cerebral malaria. The situation has become worse with the continuous emergence of drug resistance in the parasite. Therefore, improving existing drugs and deciphering new pathways for drug development are the need of the hour. The discovery of the type II fatty acid biosynthesis pathway in Plasmodium falciparum (Surolia and Su

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"Expression and characterization of the 42kDa Carboxyl-terminal processing fragment pf plasmodium falciparum merozoite surface protein-1 (PfMSP-142) in silkworm larvae using Bombyx mori nuclear polyhedrosis virus." 2000. http://library.cuhk.edu.hk/record=b6073273.

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Pang, Lap-yin.<br>"42" in title is subscript.<br>"July 2000."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (p. 163-173).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Kumar, Shailendra. "Biochemical And Molecular Insights Into β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) From Plasmodium Falciparum". Thesis, 2006. http://hdl.handle.net/2005/376.

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Malaria, caused by Plasmodium, is one of the most devastating infectious diseases of the world in terms of mortality as well as morbidity (WHO, 2002). The development of resistance in the Plasmodium falciparum against the present antimalarials has made the situation very alarming (Trape et al., 2000). To combat this situation, new antimalarials as well as identification of new drug targets are urgently required. The discovery of the presence of type II fatty acid biosynthesis system in the malarial parasite has offered several promising new targets for this mission. This thesis describes the

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Mabate, Blessing. "Exploration of interaction between Plasmodium falciparum Hsp70-x (PfHsp70-x) and human Hsp70-Hsp90 organizing protein (human Hop)." Diss., 2017. http://hdl.handle.net/11602/934.

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MSc (Biochemistry)<br>Department of Biochemistry<br>Malaria is a disease that claims about half a million lives annually, mainly children. There are 5 Plasmodium species that cause malaria; namely, P. falciparum, P. ovale, P. malariae, P. knowlesi and P. vivax. P. falciparum is the most virulent of them all. The parasite upregulates some heat shock proteins (Hsps) in response to stress it encounters during its life cycle. These Hsps play a major role in proteostasis. The drug resistance of P. falciparum to traditionally used remedies has led to a need for the development of novel drugs. Hsps h

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"Expression and characterization of the 33kDA and 42kDA carboxyl-terminal processing fragment of plasmodium falciparum merozoite surface protein-1 (MSP-1 33 and MSP-1 42) in E. coli." 2002. http://library.cuhk.edu.hk/record=b6073498.

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Leung Wai-hang.<br>"November 2002."<br>On t.p. "33" and "42" are subscripts following the word "MSP-1" in the title.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (p. 162-171).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Pavithra, S. "Functional Role Of Heat Shock Protein 90 From Plasmodium Falciparum." Thesis, 2006. http://hdl.handle.net/2005/433.

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Molecular chaperones have emerged in recent years as major players in many aspects of cell biology. Molecular chaperones are also known as heat shock proteins (HSPs) since many were originally discovered due to their increased synthesis in response to heat shock. They were initially identified when Drosophila salivary gland cells were exposed to a heat shock at 37°C for 30 min and then returned to their normal temperature of 25°C for recovery. A “puffing” of genes was found to have occurred in the chromosome of recovering cells, which was later shown to be accompanied by an increase in the syn

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Kumar, Gyanendra. "Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery." Thesis, 2007. http://hdl.handle.net/2005/589.

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Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb to death annually. Worst affected are the children below 5 years of age in sub-Saharan Africa. Plasmodium is a protozoan parasite classified under the phylum Apicomplexa that also includes parasites such as Toxoplasma, Lankestrella, Eimeria and Cryptosporidium. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, Plasmodi

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