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Relevant bibliographies by topics / Plasmodium falciparum. Malariotherapy Plasmodium falciparum Malaria / Dissertations / Theses

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Dissertations / Theses on the topic 'Plasmodium falciparum. Malariotherapy Plasmodium falciparum Malaria'

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Published: 4 June 2021

Last updated: 12 February 2022

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1

Birkholtz, Lyn-Marie. "Functional and structural characterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-06302005-120320/.

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2

Van, Brummelen Anna Catharina. "Functional genomics analysis of the effects of co-inhibition of the malarial S-adenosylmethionine decarboxylase/ornithine decarboxylase." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-05302009-124548.

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3

Human, Esmaré. "Kinetic analysis of a recombinantly expressed Plasmodium falciparum dihydrofolate synthase-folylpolyglutamate synthase." Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-06252008-093616/.

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Thesis (MSc Natural and Agricultural Sciences (Biochemistry))-University of Pretoria, 2007.<br>Summary in English and Afrikaans. Includes bibliographical references. Available on the Internet via the World Wide Web.

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4

Birkholtz, Lyn-Marie. "Functional and structural charaterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparum." Thesis, University of Pretoria, 2001. http://hdl.handle.net/2263/25944.

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Malaria remains one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapies. The need for novel therapeutic targets and drugs is therefore of the utmost importance and detailed knowledge of the biochemistry of the parasite is imperative. This study was directed at the biochemical characterisation of the polyamine metabolic pathway of P. falciparum in order to elucidate differences between the parasite and its human host that can be exploited in the design of novel antim

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5

Dhoogra, Minishca. "Gene expression profiling of polyamine-depleted Plasmodium falciparum." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-12132007-103643/.

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6

Botha, Maria Magdalena. "Structure-based inhibitor design and validation : application to Plasmodium falciparum glutathione S-transferase." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-07212008-140458/.

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7

Paul, Richard E. L. "The genetic diversity of Plasmodium falciparum." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318788.

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8

Hayward, Rhian Elizabeth. "The biology of Plasmodium falciparum gametocytes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360296.

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9

Jones, Matthew L. "Erythrocyte invasion by Plasmodium falciparum." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009r/jonesm.pdf.

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10

Ekvall, Håkan. "Plasmodium falciparum malaria and anaemia in childhood /." Stockholm, 2000. http://diss.kib.ki.se/2000/20001006ekva/.

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11

Barragan, Antonio. "Carbohydrate-mediated adhesion in Plasmodium falciparum malaria /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3977-2/.

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12

Färnert, Anna. "Diversity and dynamics of Plasmodium falciparum malaria /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4199-8/.

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13

Aidoo, Michael. "Cytotoxic T lymphocytes and Plasmodium falciparum malaria." Thesis, Open University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309865.

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14

Storey, E. "Monoclonal antibodies to merozoites of Plasmodium falciparum." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371577.

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15

Buranakitjaroen, P. "Molecular studies on merozoites of Plasmodium falciparum." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375230.

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16

Vogt, Anna. "Heparan sulfate dependent sequestration during Plasmodium falciparum malaria /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-994-3/.

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17

Walker, Alison Dalgity. "Protein variation in the malaria parasite Plasmodium falciparum." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/13171.

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18

Ranford-Cartwright, Lisa C. "Cross-fertilisation in the malaria parasite Plasmodium falciparum." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/14248.

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The objective of this work has been to investigate the frequency of cross-fertilisation between gametes of genetically distinct clones of the human malaria parasite <i>Plasmodium falciparum</i>. Previous genetic experiments involving both rodent malaria parasites <i>in vivo</i> and human malaria parasites <i>in vitro</i> have demonstrated higher than expected numbers of recombinants among the progeny of crosses. It has been suggested that this could be due to a favouring of cross-fertilisation over self-fertilisation in the mosquito phase of the life-cycle. The work has involved examining the

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19

Amenga-Etego, Naam-Kayagre Lucas. "Plasmodium falciparum population genetics in northern Ghana." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:023a6b97-5a30-4a66-bcad-0d85271062fd.

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The main thrust of this thesis was to characterize P.falciparum genetic diversity in northern Ghana. To do this, I used simple techniques to purify P. falciparum DNA from clinical samples across a rural setting for whole-genome sequencing. The goal was to provide a framework for exploring host-parasite genetic interactions. Utilizing Illumina deep sequencing data for 277 isolates I analyzed P. falciparum genetic diversity and described within-host diversity across this area. I observed random mating (ie no population structure) in the local parasite population, and a high genetic diversity ind

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20

Sicard, Audrey. "Pharmacological effect of MEK inhibitors on plasmodium falciparum." Connect to e-thesis record to view abstract, 2008. http://theses.gla.ac.uk/330/.

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Thesis (MSc.) - University of Glasgow, 2007.<br>MSc. thesis submitted to the Division of Infection and Immunity, Faculty of Biomedical and Life Sciences, University of Glasgow, 2008. Includes bibliographical references. Print copy also available.

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21

Parraguez, de la Cruz Jorge Enrique, and Salcedo Ricardo Alvaro Santos. "Antígenos relevantes de Plasmodium vivax y Plasmodium falciparum detectados mediante inmunoblot : Iquitos 2004." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2008. https://hdl.handle.net/20.500.12672/448.

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El objetivo del presente trabajo fue identificar antígenos relevantes de valor diagnóstico de aislados de P. vivax y P. falciparum provenientes del departamento de Loreto, mediante la técnica de inmunoblot. Se seleccionaron pacientes entre 3 y 64 años con diagnóstico de malaria, gota gruesa positiva, procedentes de centros de salud en el departamento de Loreto. Fueron analizadas 4 mezclas de antígenos, una de P. falciparum (PF1) y tres de P. vivax (PV1, PV4 y PV5), preparadas a partir de 36 muestras de pacientes con alta parasitemia por P. vivax (2 700 – 69 000 parásitos/μL) y P. falciparum (2

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22

De, Beer Tjaart Andries Petrus. "In silico structural characterisation of Plasmodium falciparum dihydro-6-hydroxymethylpterin pyrophosphokinase dihydropteroate synthase (PPPK-HPS)." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-03022006-160134.

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23

Pettersson, Fredrik. "Sequestration, virulence and future interventions in Plasmodium falciparum malaria." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-568-2/.

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24

Huot, Chantheany Pornthep Chanthavanich. "Clinical manifestation of uncomplicated falciparum malaria and vivax malaria in Thai children /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd363/4638516.pdf.

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25

Witney, Adam Austin. "Molecular characterisation of a novel cyclase from plasmodium falciparum." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286765.

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26

DaRe, Jeana Theresa. "Investigation of Strain Diversity in Plasmodium Falciparum Populations From Papua New GuineaInvestigation of Strain Diversity in Plasmodium Falciparum Populations From Papua New Guinea." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1238788956.

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27

Heddini, Andreas. "Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria /." Stockholm : [Karolinska institutets bibl.], 2001.

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28

Mharakurwa, Sungano. "Epidemiology of drug-resistant Plasmodium falciparum malaria in Zimbabwe." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393378.

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29

Mubjer, Reem Abdul-Kader. "Studies on drug resistant Plasmodium falciparum malaria in Yemen." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428252.

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30

Wall, Bridget (Bridget Anne). "Engineered tools for studying the malaria parasite plasmodium falciparum." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98923.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from PDF student-submitted version of thesis.<br>Includes bibliographical references (pages 120-136).<br>New techniques to both prevent and treat the disease malaria are necessary. To develop these novel strategies, innovative tools must be designed to study the basic biology within Plasmodium falciparum and characteristics of the patho

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31

Tétard, Marilou. "Mechanisms associated to hemoglobinopathic protection against plasmodium falciparum malaria." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC257.

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La protection contre le paludisme, conférée par les hémoglobinopathies (HbS et HbC), a été bien définie mais les mécanismes moléculaires et cellulaires sous-jacents restent méconnus. Un des mécanismes proposés, implique une présentation anormale des PfEMP1 à la surface des globules rouges infectés et a été associé à une diminution de l’expression de surface de ces PfEMP1 causant une diminution de l’adhérence des globules rouges parasités (GRp) aux cellules de l’endothélium vasculaire. Dans une étude de cohorte de femmes enceintes au Bénin, nous avons premièrement montré que le génotype HbAC et

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32

Higham, Christopher W. "A study of lactate dehydrogenase from Plasmodium falciparum." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299529.

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33

Buthsaraporn, Surakhaka Polrat Wilairatana. "Therapeutic response of falciparum malaria in relation to in vitro sensitivity of plasmodium falciparum /." Abstract, 2000. http://mulinet3.li.mahidol.ac.th/thesis/2543/43E-Buthsaraporn-S.pdf.

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34

Certad, Gabriela. "Characterization of drug-resistant isolates of Plasmodium falciparum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0017/MQ37102.pdf.

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35

Certain, Laura K. "Genetic profiling of drug resistance in Plasmodium falciparum /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10252.

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36

Bereczky, Sándor. "Genetic diversity of Plasmodium falciparum infections : influence on protective malaria immunity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-548-8/.

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37

Curra, Chiara. "Protein trafficking and host cell remodeling in malaria parasite infection." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20219.

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Pour assurer ses besoins de croissance, multiplication, et survie, Plasmodium modifie sa cellule hôte, l'érythrocyte, après l'invasion. Le parasite met en place ainsi un système d'échanges (import/export) avec sa cellule hôte et le milieu extérieur. Nous avons identifié dans la base de données de Plasmodium berghei, le parasite de rongeurs, une famille de gènes, sep, correspondant à la famille etramp chez Plasmodium falciparum. Cette famille de gènes code pour des petites protéines exportées, et conservées dans tout le genre Plasmodium. Les protéines SEP (13?16 kDa) contiennent en N-terminal u

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38

Daniels, Rachel Fath. "Genomic Tools Reveal Changing Plasmodium falciparum Populations." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10931.

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A new era of malaria eradication programs relies on increased knowledge of the parasite through sequencing of the Plasmodium genome. Programs call for re-orientation at specific epidemiological markers as regions move from control towards pre- and total elimination. However, relatively little is known about the effects of intervention strategies on the parasite population or if the epidemiological cues correspond to effects on the parasite population. We hypothesized that genomic tools could be used to track population changes in Plasmodium falciparum to detect significant shifts as eradicatio

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39

Hunja, Carol Wangui. "Feasibility study exploring the spatial distribution of Plasmodium falciparum." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9375.

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The way malaria parasites are transmitted in space will have an influence on their genetic relationships. It can be expected that parasites collected within close geographic distances of each other would be more closely related than those across large geographic distances. Further to this, because malaria transmission is focal and heterogeneous in space, then the genetic relatedness between malaria parasites in these foci of malaria transmission would be greater within tightly clustered regions. Thus, using the level of genetic relatedness of these parasites would reveal how they are transmitt

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40

Pulcini, Serena. "Studies on the mechanisms of action of artemisinins and the role of PfATP6." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20138/document.

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La pompe ATPase Ca2+ du réticulum sarco-endoplasmique Plasmodium falciparum (PfATP6) est une protéine de dix transmembranes, impliqué dans la régulation de l'homéostasie du calcium dans le parasite. L'importance d'étudier cette protéine repose sur l'hypothèse d'être engagé dans le mécanisme d'action et de résistance des artémisinines. Des travaux précédents, fondé sur l'expression hétérologue dans des ovocytes de Xenopus laevis et Saccharomyces cerevisiae, ont montré des résultats opposés, générant de nombreux corollaires vérifiables. Par conséquent, des travaux supplémentaires sont nécessaire

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41

Vasconcelos, Nina-Maria. "Vaccine development strategies applied to the Plasmodium falciparum malaria antigen Pf332 /." Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1263.

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42

Elsideg, Ahmed Mohammed Abdelrhaman Watcharapong Piyaphanee. "Emergence and clearance of gametocytes in complicated plasmodium falciparum Malaria /." Abstract, 2008. http://mulinet3.li.mahidol.ac.th/thesis/2551/cd414/5038615.pdf.

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Thematic Paper (M.C.T.M.(Clinical Tropical Medicine)--Mahidol University, 2008.<br>LICL has E-Thesis 0038 ; please contact computer services. LIRV has E-Thesis 0038 ; please contact circulation services.

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43

Tiwari, Bela. "The variant antigen, PfEMP1 and the biology of Plasmodium falciparum." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267956.

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44

Sedillo, Jennifer L. "Pathogenic mechanisms and signaling pathways in Plasmodium falciparum." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5123.

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Plasmodium falciparum is a human intracellular parasite that is the causative agent of a deadly form of malaria. This species alone is responsible for 200 million cases of malaria annually resulting in over 1 million deaths worldwide. The excessive mortality due to P. falciparum infection is due to its ability to cause severe pathogenesis through hyperparasitemia and cytoadherence defined as the ability of infected red blood cells to adhere to host vasculature. Cytoadherence is mediated through the export of parasite proteins to the surface of the infected red blood cell (RBC). Exported protei

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45

Hamilton, William Lyle. "Rate, spectrum and genome-wide distribution of spontaneous mutation in the malaria parasite Plasmodium falciparum." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709391.

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46

Corrigan, Ruth Alexandra. "Rosetting and the innate immune response to Plasmodium falciparum." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4041.

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Rosetting is an adhesion property of malaria parasites whereby infected erythrocytes bind to two or more uninfected erythrocytes, forming a so-called rosette. Rosetting of Plasmodium falciparum is associated with disease severity and high parasitaemia in sub-Saharan Africa, although currently the function of rosetting remains unknown. An early IFNg response elicited from the innate immune system is associated with resolution of malaria infection in mice. Published data suggests that optimal IFNg production may require contact between peripheral blood mononuclear cells and P. falciparum infecte

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47

Ahuja, Sanjay. "Development of a recombinant protein vaccine against Plasmodium falciparum malaria /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-788-X/.

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48

Galusic, Sandra. "MMV Malaria Box Activity Screening in Dormant Plasmodium falciparum Phenotypes." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5687.

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The causative agent of malignant tertian malaria, Plasmodium falciparum undergoes an arrested growth phenotype of its erythrocytic stage when under drug-stress. Recent artemisinin treatment failures seem to be indicative of such induction followed by recrudescence rather than actual therapeutic failure. Likewise, P. vivax hypnozoites are the prototypic dormants and the latent infections for which they are responsible prove most difficult to treat. Dihydroartemisinin, an artemisinin-derivative, can be used to exploit this mechanism by inducing a dormant state in ring-stage P. falciparum parasit

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49

Kamuyu, Gathoni. "Identifying merozoite targets of protective immunity against Plasmodium falciparum malaria." Thesis, Open University, 2017. http://oro.open.ac.uk/51139/.

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The observation that individuals living in malaria endemic regions who are repeatedly infected with <i>P. falciparum</i> can acquire immunity, first to severe, then to uncomplicated clinical episodes of malaria, and finally to high parasite densities, provides hope that a vaccine is achievable. Immunoglobulins have been identified as a key component of naturally acquired immunity and identifying the targets and mechanisms by which this protection is achieved is a clear research priority. To date, only a small proportion of the parasite proteome has been evaluated in the context of naturally ac

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50

Park, Daniel John. "Evolutionary Adaptation and Antimalarial Resistance in Plasmodium falciparum." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11088.

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The malaria parasite, Plasmodium falciparum, has a demonstrated history of adaptation to antimalarials and host immune pressure. This ability unraveled global eradication programs fifty years ago and seriously threatens renewed efforts today. Despite the magnitude of the global health problem, little is known about the genetic mechanisms by which the parasite evades control efforts. Population genomic methods provide a new way to identify the mutations and genes responsible for drug resistance and other clinically important traits.

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