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Dissertations / Theses on the topic 'Plasmodium parasite'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Curra, Chiara. "Protein trafficking and host cell remodeling in malaria parasite infection." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20219.

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Pour assurer ses besoins de croissance, multiplication, et survie, Plasmodium modifie sa cellule hôte, l'érythrocyte, après l'invasion. Le parasite met en place ainsi un système d'échanges (import/export) avec sa cellule hôte et le milieu extérieur. Nous avons identifié dans la base de données de Plasmodium berghei, le parasite de rongeurs, une famille de gènes, sep, correspondant à la famille etramp chez Plasmodium falciparum. Cette famille de gènes code pour des petites protéines exportées, et conservées dans tout le genre Plasmodium. Les protéines SEP (13?16 kDa) contiennent en N-terminal u

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2

Walker, Alison Dalgity. "Protein variation in the malaria parasite Plasmodium falciparum." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/13171.

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3

Ranford-Cartwright, Lisa C. "Cross-fertilisation in the malaria parasite Plasmodium falciparum." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/14248.

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The objective of this work has been to investigate the frequency of cross-fertilisation between gametes of genetically distinct clones of the human malaria parasite <i>Plasmodium falciparum</i>. Previous genetic experiments involving both rodent malaria parasites <i>in vivo</i> and human malaria parasites <i>in vitro</i> have demonstrated higher than expected numbers of recombinants among the progeny of crosses. It has been suggested that this could be due to a favouring of cross-fertilisation over self-fertilisation in the mosquito phase of the life-cycle. The work has involved examining the

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4

Green, Judith Louise. "Genes encoding rhoptry proteins of the malaria parasite plasmodium." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300303.

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5

Chadwick, Catherine Joyce. "Immunocytochemical studies on the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357377.

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6

Wall, Bridget (Bridget Anne). "Engineered tools for studying the malaria parasite plasmodium falciparum." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98923.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from PDF student-submitted version of thesis.<br>Includes bibliographical references (pages 120-136).<br>New techniques to both prevent and treat the disease malaria are necessary. To develop these novel strategies, innovative tools must be designed to study the basic biology within Plasmodium falciparum and characteristics of the patho

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7

Sharkey, Andrew M. "Genetic variation in the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/14391.

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8

Bucsu, Eva. "Plasmodium chabaudi adami : vaccine antigens and antigenic variation /." Connect to thesis, 2003. http://repository.unimelb.edu.au/10187/2881.

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There is an abundance of information available on the molecular mechanisms of antigenic variation in Plasmodium falciparum. The variant antigen PfEMP1, which mediates antigenic variation as well as cytoadherence and rosetting, has been extensively characterised. Genes coding for the antigen belong to the gene family var, and several var genes have been cloned and characterised. The rodent malaria parasite P. chabaudi is a widely studied in vivo model for P. falciparum. The P. c. chabaudi AS parasite strain has been shown to exhibit antigenic variation and the variant antigen has been detected

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9

De, Aguiar J. C. S. "Studies on the polymorphic schizont antigen of Plasmodium chabaudi." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383640.

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10

Aidoo, Michael. "Cytotoxic T lymphocytes and Plasmodium falciparum malaria." Thesis, Open University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309865.

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11

Jones, Matthew L. "Erythrocyte invasion by Plasmodium falciparum." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009r/jonesm.pdf.

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12

Kurniawan, Davy Putra. "Characterisation of the apicoplast transcripts in the human malaria parasite Plasmodium falciparum." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607909.

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13

Dhanasarnsombut, Kelwalin. "Unstructured proteins of the malaria parasite Plasmodium falciparum as vaccine candidates." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8034.

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Malaria vaccine research has been battling with persistent challenges, including polymorphisms of vaccine antigens, difficulties with production processes, and limited immune protection against the disease. Intrinsically unstructured proteins (IUPs) are a fairly newly classified group of proteins that have no stable 3D structure and are generally heat-resistant. They usually contain low complexity regions and repetitive sequences, both of which are distinct characteristics of the malaria proteome. Surprisingly, some of the vaccine candidates that have been extensively studied were later report

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14

Tedder, Philip Martin Richard. "Multi-source gene function prediction in the malaria parasite Plasmodium falciparum." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534842.

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15

Chang, Hsiao-Han. "Genomic variation and evolution of the human malaria parasite Plasmodium falciparum." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10774.

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Malaria is a deadly disease that causes nearly one million deaths each year. Understanding the demographic history of the malaria parasite Plasmodium falciparum and the genetic basis of its adaptations to antimalarial treatments and the human immune system is important for developing methods to control and eradicate malaria. To study the long-term demographic history and recent effective size of the population in order to identify genes under selection more efficiently and predict the effectiveness of selection, in Chapter 2 we sequenced the complete genomes of 25 cultured P. falciparum isolat

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16

Cummings, Ross Martin. "Studies on cyclic nucleotide phosphodiesterases in the malaria parasite Plasmodium falciparum." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420814.

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17

Van, Schalkwyk Donelly Andrew. "The interaction of verapamil with the human malaria parasite : Plasmodium falciparum." Doctoral thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/3303.

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18

Chan, Shiu-Wan. "Aspects of pyrimethamine resistance in the human malaria parasite Plasmodium falciparum." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/13353.

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Pyrimethamine is a commonly used drug in prophylactic and therapeutic treatment of human malaria caused by the parasite <i>Plasmodium falciparum</i>. It has been postulated that the mode of action of pyrimethamine is by inhibition of the enzyme dihydrofolate reductase (DHFR). This was tested genetically in the first part of the study using a cross between a pyrimethamine sensitive and a pyrimethamine resistant cloned line 3D7 and HB3. The results of restriction-fragment-length-polymorphism (RFLP) analysis on the pattern of pyrimethamine resistance inheritance in the progeny confirm that the mu

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19

McLean, Ann Paterson. "Genetic studies on antigens of the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/15353.

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20

Miliu, Alexandra Victoria. "Role of the phosphatases over the erythrocytic cycle of the malaria parasite Plasmodium falciparum." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT029/document.

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Plasmodium falciparum, l'agent étiologique du paludisme, est un parasite intracellulaire obligatoire du phylum des Apicomplexa, responsable de 445 000 décès par an. Le développement de Plasmodium dans les globules rouges (GRs) humains correspond à la phase symptomatique de la maladie. Il commence par la pénétration active de la cellule hôte par la forme invasive nommée mérozoïte, suivie par la multiplication du parasite dans un processus appelé schizogonie pour former 16 à 32 nouveaux mérozoïtes qui sont alors libérés des GRs (étape de sortie) et peuvent alors initier un nouveau cycle. Au cour

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21

Hamilton, William Lyle. "Rate, spectrum and genome-wide distribution of spontaneous mutation in the malaria parasite Plasmodium falciparum." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709391.

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22

Crick, Alex James. "Live imaging studies of the interactions of the malaria parasite with the human erythrocyte." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708165.

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23

Ghezal, Salma. "Etude métabolomique par LC-MS/MS chez Plasmodium Falciparum, parasite responsable du Paludisme." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20179.

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La forme la plus sévère de paludisme est causée par le parasite unicellulaire P. falciparum. Lors de la phase intra-érythrocytaire de son développement, P. falciparum met en place des fonctions métaboliques nécessaires à son développement dans l'érythrocyte, à sa multiplication et enfin à sa dissémination vers d'autres érythrocytes. Comprendre et élucider les structures et les dynamiques du réseau métabolique chez le parasite, permettent de découvrir de nouvelles voies métaboliques et des étapes clefs qui peuvent jouer un rôle important dans le développement du parasite. Elles permettent égale

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24

Raabe, Andreas Christian. "Rôle de la phospholipase C, des phosphoinositides et du calcium dans la gamétogenèse de Plasmodium berghei, parasite du paludisme." Montpellier 2, 2008. http://www.theses.fr/2008MON20081.

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Une étape cruciale dans le cycle de Plasmodium, parasite causal du paludisme est sa transmission de l'hôte vertébré au moustique vecteur. Seuls les stades sanguins sexués sont capables de se développer dans le moustique. Chez le moustique, le nouvel environnement déclenche une cascade de signalisation conduisant à la gamétogenèse. Les travaux de thèse ont pour objectifs d'élucider cette cascade de signalisation qui joue un rôle clé dans la transmission du paludisme. Des approches pharmacologiques biochimiques et génétiques ainsi que des études d'imagerie ont été utilisées et fournissent de mul

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25

Mubaraki, Murad. "Pharmacometabolomic study of the human malaria parasite, Plasmodium falciparum : new insights into parasite biology and mode of drug action." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/12337/.

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Malaria is a vector-borne parasitic disease spread by a bite of an infected female Anopheles mosquito that accounts for high morbidity and mortality, mainly in sub-Saharan Africa. Of the five species that can cause malaria in humans, Plasmodium falciparum is regarded the most virulent species. Antimalarial drugs, unaltered for many decades, remain the mainstay for treating P. falciparum infection. In addition, despite intensive research there remain significant knowledge gaps in understanding of the biology of the malaria parasite P. falciparum. These deficiencies hinder the ability of scienti

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26

Thavayogarajah, Thuvaraka [Verfasser]. "An Alternative Secretory Pathway in the Malaria Parasite 'Plasmodium falciparum' / Thuvaraka Thavayogarajah." München : GRIN Verlag, 2017. http://d-nb.info/1180304365/34.

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27

Lucas, Stuart James. "Genetic manipulation and gene expression in the human malaria parasite Plasmodium falciparum." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405550.

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28

Yim, Lim Brian Youn Sen. "The RhopH1/Clag gene family in the human malaria parasite Plasmodium falciparum." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446012/.

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The obligate intracellular parasite Plasmodium falciparum causes the most severe forms of human malaria. Apical rhoptry organelles of invasive merozoites contain proteins that are instrumental to the intraerythrocytic development of the parasite. Our group has determined that the RhopHl protein of the high molecular mass rhoptry complex (RhopH) is encoded by genes of the highly-conserved clag (cytoadherence-linked asexual gene) family. In this study, the characterisation of the RhopH 1/Clag proteins is continued. It was ascertained that the family has five members in P. falciparum 3D7 (clag2,

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29

Denloye, Titilola Ifeoma. "Characterization of a glycerophosphodiester phosphodiesterase in the human malaria parasite Plasmodium falciparum." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77090.

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Active lipid metabolism is a key process required for the intra-erythrocytic development of the malaria parasite, Plasmodium falciparum. Enzymes that hydrolyze host-derived lipids play key roles in parasite growth, virulence, differentiation, cell-signaling and hemozoin formation. Therefore, investigating enzymes involved in lipid degradation could uncover novel drug targets. We have identified in P. falciparum, a glycerophosphodiester phosphodiesterase (PfGDPD), involved in the downstream pathway of phosphatidylcholine degradation. PfGDPD hydrolyzes deacylated phospholipids, glycerophosphodie

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30

Sen, Partho. "Modélisation intégrée du métabolisme des lipides chez Plasmodium, parasite causal du paludisme." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20153/document.

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Le paludisme est responsable de la mort de près d'un million de personnes chaque année. Cette maladie est causée par le Plasmodium, parasite protozoaire appartenant à la famille des Apicomplexes. Dans cette thèse, nous avons développé des approches de biologie de systèmes pour l'étude du métabolisme des phospholipides (PL) métabolisme et de sa régulation chez Plasmodium. Ces voies métaboliques sont d'une importance primordiale pour la survie du parasite. À l'étape intra-érythrocytaire du développement, les espèces de Plasmodium exploitent un nombre important de voies de synthèse phospholipidiq

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31

Carlton, Jane M. R. "The genetics of chloroquine resistance in the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/13312.

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The aim of this work has been to use linkage analysis to determine the chromosomal location of genes involved in chloroquine resistance in the rodent malaria parasite <I>Plasmodium chabaudi</I>. The <I>P. chabaudi</I> genome was found to contain 14 chromosomes. A genetic map of each chromosome was made using DNA markers. Most of the markers were known genes from other species of <I>Plasmodium</I>. Other markers were developed by the RAPD-PCR (random amplified polymorphic DNA-polymerase chain reaction) technique, the first time this method has been developed for use with <I>Plasmodium</I> paras

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32

Sethia, Sonal. "Etudes métabolomiques du métabolisme du carbone des stades érythrocytaires asexués du parasite du paludisme humain Plasmodium falciparum." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT046.

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Le paludisme est une des maladies tropicales les plus dévastatrices au monde causée par des parasites protozoaires intracellulaires du genre Plasmodium. Cinq espèces de plasmodies sont responsables du paludisme chez l'homme et causent 600 000 décès par an principalement chez les enfants de moins de 5 ans et les femmes enceintes vivant dans les régions les plus pauvres du globe. Les parasites ont généré une résistance contre les chimiothérapies existantes et aucun vaccin efficace n'est encore disponible. Il est donc impératif d'identifier et de valider de nouvelles cibles qui peuvent être explo

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33

Ebrahimzadeh, Zeinab. "Exploring the roles of phosphoinositides in the biology of the malaria parasite Plasmodium falciparum." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/37075.

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Plasmodium falciparum est un parasite appartenant au phylum Apicomplexa et est à l’origine de la forme la plus sévère de la malaria. Dans les zones endémiques d'Afrique subsaharienne, la plupart des victimes sont des enfants de moins de cinq ans. L’entrée de P. falciparum dans sa cellule cible, le globule rouge, repose sur la sécrétion de protéines par des organites spécialisés : les micronèmes, les rhoptries et les granules denses. Les mécanismes de biogenèse de ces organites et la coordination de la libération de leur contenu lors de l'invasion sont cependant pour la plupart inconnus. Il a é

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34

Srinivasan, Prakash. "The Role of Rhomboid proteases and a Oocyst Capsule protein in Malaria Pathogenesis and Parasite Development." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1181352186.

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35

Wilkins, Simon. "Lectin-carbohydrate mediated interaction between Plasmodium ookinetes and the mosquito midgut." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367836.

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36

Suárez, Catherine. "Function and regulation of a serine protease implicated in malaria parasite remodelling and egress." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20209.

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Le paludisme demeure une des maladies infectieuses les plus meurtrières au monde. Propagé par la piqûre d’un moustique femelle du genre Anopheles, le parasite du paludisme (Plasmodium) migre dans la circulation sanguine et infecte les cellules hépatiques de la victime. Dans le foie, le parasite se différencie et se reproduit par schizogonie à l’intérieur d’une vacuole parasitophore pour compléter la production de plusieurs milliers de mérozoïtes par cellule hépatique infectée. Ces mérozoïtes sont par la suite libérés dans la circulation sanguine où ils infectent les érythrocytes circulants dan

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37

Meding, Sally Joanna. "CD4'+ T cell effector mechanisms in the protective immune response to Plasmodium chabaudi chabaudi." Thesis, Brunel University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280689.

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38

Carter, William. "RAMAN SPECTROSCOPIC STUDY OF SINGLE RED BLOOD CELLS INFECTED BY THE MALARIA PARASITE PLASMODIUM FALCIPARUM." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4269.

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Raman micro-spectroscopy provides a non-destructive probe with potential applications as a diagnostic tool for cellular disorders. This study presents micro-Raman spectra of live erythrocytes infected with a malaria parasite and investigates the potential of this probe to monitor molecular changes which occur during differentiation of the parasite inside the cell. At an excitation wavelength of 633 nm the spectral bands are dominated by hemoglobin vibrations yielding information the on structure and spin state of the heme moiety. It also demonstrates the novel use of silica capillaries as a vi

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39

Buitrago, Amanda Elena Maestre. "Immunity to malaria using the rodent malaria parasite Plasmodium chabaudi AS as a model of the human malaria Plasmodium falciparum." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298916.

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40

Rodriguez, Gutierrez Maria del Carmen. "Characterisation of ookinete stage specific molecules from the rodent malaria parasite Plasmodium berghei." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271484.

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41

Abd, Majid Roslaini. "Molecular and biochemical pharmacology of mitochondrial enzymes in the malaria parasite Plasmodium falciparum." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574668.

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The mitochondria of malaria have big potential to be explored as a drug targeting site. This is due to the differences in the composition of the Plasmodium respiratory complex compared with the human host. The Plasmodium respiratory chain consists of 2 unique dehydrogenases PfNDH2 and MQO which are only encoded in prokaryotic cells. Apart from these two, thy Plasmodium bc1 complex has low amino acid similarity when compared to the bc1 cQmplex of other eukaryotes. Currently the only approved antimalarial drug targeting Plasmodium mitochondria is atovaquone. This drug is used in combination with

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42

Pauli, Kathrin [Verfasser]. "Characterization of peroxiredoxins and plasmoredoxin of the malarial parasite Plasmodium falciparum / Kathrin Pauli." Gießen : Universitätsbibliothek, 2021. http://d-nb.info/122882908X/34.

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43

Ross-Macdonald, Petra B. "Isolation of a cell cycle control gene from the malaria parasite Plasmodium falciparum." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329897.

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44

Goldfless, Stephen J. (Stephen Jacob). "Engineering control of eukaryotic translation with application to the malaria parasite Plasmodium falciparum." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/88903.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 123-130).<br>Experimenter control of target gene expression is a fundamental component of molecular biology research. In many systems, tools exist that allow generalizable control of gene expression at the transcriptional or post-transcriptional level. Plasmodium falciparum, the protozoan parasite responsible for the majority of death and sickness due to malaria, remains challenging to manipulate in the laborat

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45

Le, Grange Misha. "High-throughput prioritization of putative drug targets in the malaria parasite, Plasmodium falciparum." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/46174.

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Drug resistance to almost all known antimalarials is widespread and is rapidly increasing. This resistance is due to the over and misuse of these antimalarials, thus new antimalarial drugs are necessary to help in the prevention and cure of this widespread disease. Continuous in-depth studies are being done on a handful of putative targets for future exploitation and use, but not many resources are available that focus on performing data mining and target identification on the complete malaria genome, together with relations to chemical compounds. The DISCOVERY Database is a web-based sy

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46

Gaumond, David. "Caractérisation d'un effecteur de phosphoinositides chez le parasite de la malaria Plasmodium falciparum." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27231.

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La malaria est une maladie infectieuse causant plus de 500 000 morts chaque année. La maladie est causée par un protozoaire de la famille Plasmodium. L’apparition de souches résistantes aux traitements actuels et l’absence de vaccin efficace rendent la découverte de nouvelles cibles thérapeutiques urgente. Le parasite possède un complexe apical, un groupement de vacuoles sécrétoires spécialisées contenant les protéines responsables de l’invasion du globule rouge. Nous nous intéressons aux mécanismes gouvernant le transport intracellulaire de ces protéines et à la biogenèse du complexe apical l

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47

Meaden, Cora S. J. "Genetic determinants of gametocyte sex ratio in the human malaria parasite Plasmodium falciparum." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4700/.

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The aim of this study was to investigate the genetic basis of variation in gametocyte sex ratio in the human malaria parasite, Plasmodium falciparum. The gametocyte sex ratio was measured in progeny clones from the 3D7 x HB3 experimental genetic cross and found to be remarkably stable across replicates of different parasite clones. Significant differences in the sex ratio were observed between the parents of the cross. Progeny clones fell into two classes of sex ratio, one similar to that seen in parent 3D7 and the other like parent HB3, suggesting a single gene of major effect controlling sex

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48

Read, Martin. "Investigations into aspects of central metabolism in the human malaria parasite Plasmodium falciparum." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/investigations-into-aspects-of-central-metabolism-in-the-human-malaria-parasite-plasmodium-falciparum(8db40369-5155-4f08-8326-eb262e50babd).html.

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This thesis combines four published research papers and a book chapter investigating aspects of central metabolism in the human malaria parasite Plasmodium falciparum. The publications are preceded by a statement which explores features of the research not fully described in the published texts, incorporates a review of the development over time and the present state of relevant scientific knowledge, and discusses the place of the individual papers and book chapter within malaria research. An assessment of the impact of each publication on its field of study is also included. A general discuss

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49

Akaddar, Aziza. "Etude de l'effet d'un peptide antimicrobien, la Catestatine sur la croissance de Plasmodium, parasite du paludisme." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13199.

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50

Maestre, Buitrago Amanda Elena. "Immunity to malaria using the rodent malaria parasite Plasmodium chabaudi chabaudi AS as a model of the human malaria Plasmodium falciparum." Thesis, University of Glasgow, 1997. http://theses.gla.ac.uk/2036/.

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The role of IFN in acquisition of immunity against erythrocyte forms of P.c. chabaudi AS was studied. Inbred NIH mice given the construct 7 days before malaria infection, showed a significant delay in the onset and in the level of the recrudescent parasitaemia in comparison with controls. No differences, however, were observed in the recrudescent parasitaemia between the groups. NIH mice infected with malaria 3 days after or on the same day as the administration of the IFN construct, showed a primary peak of infection similar to controls, but the resolution of this patent parasitaemia occurred

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