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Journal articles on the topic 'Plasmodium parasites'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

HANADA, Kentaro, Toshihide MITAMURA, Masayoshi FUKASAWA, Pamela A. MAGISTRADO, Toshihiro HORII, and Masahiro NISHIJIMA. "Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum." Biochemical Journal 346, no. 3 (2000): 671–77. http://dx.doi.org/10.1042/bj3460671.

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Sphingolipid metabolism and metabolites are important in various cellular events in eukaryotes. However, little is known about their function in plasmodial parasites. Here we demonstrate that neutral sphingomyelinase (SMase) involved in the sphingomyelin (SM) catabolism is retained by the intraerythrocytic parasite Plasmodium falciparum. When assayed in a neutral pH buffer supplemented with Mg2+ and phosphatidylserine, an activity for the release of the phosphocholine group from SM was detected in parasite-infected, but not in uninfected, erythrocyte ghosts. The SMase activity in the parasite-

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2

Sá e Cunha, Cláudia, Britta Nyboer, Kirsten Heiss, et al. "Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development." Proceedings of the National Academy of Sciences 114, no. 7 (2017): E1138—E1147. http://dx.doi.org/10.1073/pnas.1606419114.

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The first, obligatory replication phase of malaria parasite infections is characterized by rapid expansion and differentiation of single parasites in liver cells, resulting in the formation and release of thousands of invasive merozoites into the bloodstream. Hepatic Plasmodium development occurs inside a specialized membranous compartment termed the parasitophorous vacuole (PV). Here, we show that, during the parasite’s hepatic replication, the C-terminal region of the parasitic PV membrane protein exported protein 1 (EXP-1) binds to host Apolipoprotein H (ApoH) and that this molecular intera

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3

Jaramillo Ponce, José R., and Magali Frugier. "Plasmodium, the Apicomplexa Outlier When It Comes to Protein Synthesis." Biomolecules 14, no. 1 (2023): 46. http://dx.doi.org/10.3390/biom14010046.

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Plasmodium is an obligate intracellular parasite that has numerous interactions with different hosts during its elaborate life cycle. This is also the case for the other parasites belonging to the same phylum Apicomplexa. In this study, we bioinformatically identified the components of the multi-synthetase complexes (MSCs) of several Apicomplexa parasites and modelled their assembly using AlphaFold2. It appears that none of these MSCs resemble the two MSCs that we have identified and characterized in Plasmodium. Indeed, tRip, the central protein involved in the association of the two Plasmodiu

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4

Kalanon, Ming, and Geoffrey I. McFadden. "Malaria, Plasmodium falciparum and its apicoplast." Biochemical Society Transactions 38, no. 3 (2010): 775–82. http://dx.doi.org/10.1042/bst0380775.

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Malaria, which is caused by species of the parasite genus Plasmodium, remains a major global health problem. A vestigial plastid homologous with the chloroplasts of plants and algae was discovered in malaria and related parasites from the phylum Apicomplexa and has radically changed our view of the evolutionary origins of these disease-causing protists. We now recognize that this large group of parasites had a photosynthetic ancestry and were converted into parasitism early in the evolution of animals. Apicomplexans have probably been parasitizing the animal kingdom for more than 500 million y

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5

Perkins, Susan L., and Jos J. Schall. "A molecular phylogeny of malarial parasites recovered from cytochrome b gene sequences." Journal of Parasitology 88, no. 5 (2002): 972–78. https://doi.org/10.5281/zenodo.13524290.

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(Uploaded by Plazi for the Bat Literature Project) A phylogeny of haemosporidian parasites (phylum Apicomplexa, family Plasmodiidae) was recovered using mitochondrial cytochrome b gene sequences from 52 species in 4 genera (Plasmodium, Hepatocystis, Haemoproteus, and Leucocytozoon), including parasite species infecting mammals, birds, and reptiles from over a wide geographic range. Leucocytozoon species emerged as an appropriate out-group for the other malarial parasites. Both parsimony and maximum-likelihood analyses produced similar phylogenetic trees. Life-history traits and parasite morpho

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6

Perkins, Susan L., and Jos J. Schall. "A molecular phylogeny of malarial parasites recovered from cytochrome b gene sequences." Journal of Parasitology 88, no. 5 (2002): 972–78. https://doi.org/10.5281/zenodo.13524290.

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(Uploaded by Plazi for the Bat Literature Project) A phylogeny of haemosporidian parasites (phylum Apicomplexa, family Plasmodiidae) was recovered using mitochondrial cytochrome b gene sequences from 52 species in 4 genera (Plasmodium, Hepatocystis, Haemoproteus, and Leucocytozoon), including parasite species infecting mammals, birds, and reptiles from over a wide geographic range. Leucocytozoon species emerged as an appropriate out-group for the other malarial parasites. Both parsimony and maximum-likelihood analyses produced similar phylogenetic trees. Life-history traits and parasite morpho

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7

Perkins, Susan L., and Jos J. Schall. "A molecular phylogeny of malarial parasites recovered from cytochrome b gene sequences." Journal of Parasitology 88, no. 5 (2002): 972–78. https://doi.org/10.5281/zenodo.13524290.

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(Uploaded by Plazi for the Bat Literature Project) A phylogeny of haemosporidian parasites (phylum Apicomplexa, family Plasmodiidae) was recovered using mitochondrial cytochrome b gene sequences from 52 species in 4 genera (Plasmodium, Hepatocystis, Haemoproteus, and Leucocytozoon), including parasite species infecting mammals, birds, and reptiles from over a wide geographic range. Leucocytozoon species emerged as an appropriate out-group for the other malarial parasites. Both parsimony and maximum-likelihood analyses produced similar phylogenetic trees. Life-history traits and parasite morpho

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8

Perkins, Susan L., and Jos J. Schall. "A molecular phylogeny of malarial parasites recovered from cytochrome b gene sequences." Journal of Parasitology 88, no. 5 (2002): 972–78. https://doi.org/10.5281/zenodo.13524290.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) A phylogeny of haemosporidian parasites (phylum Apicomplexa, family Plasmodiidae) was recovered using mitochondrial cytochrome b gene sequences from 52 species in 4 genera (Plasmodium, Hepatocystis, Haemoproteus, and Leucocytozoon), including parasite species infecting mammals, birds, and reptiles from over a wide geographic range. Leucocytozoon species emerged as an appropriate out-group for the other malarial parasites. Both parsimony and maximum-likelihood analyses produced similar phylogenetic trees. Life-history traits and parasite morpho

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9

Tewari, Rita, Solabomi A. Ogun, Ruwani S. Gunaratne, Andrea Crisanti, and Anthony A. Holder. "Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo." Blood 105, no. 1 (2005): 394–96. http://dx.doi.org/10.1182/blood-2004-06-2106.

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Abstract Merozoite invasion of red blood cells is crucial to the development of the parasite that causes malaria. Merozoite surface proteins (MSPs) mediate the first interaction between parasite and erythrocyte. In Plasmodium falciparum, they include a complex of products from at least 3 genes (msp1, msp6, and msp7), one of which, msp7, is part of a gene family containing 3 and 6 adjacent members in Plasmodium yoelii and Plasmodium falciparum, respectively. We have identified and disrupted msp7 in the Plasmodium berghei gene family. The protein is expressed in schizonts and colocalizes with MS

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10

Morgan, D. M. L., U. Bachrach, Y. G. Assaraf, E. Harari, and J. Golenser. "The effect of purified aminoaldehydes produced by polyamine oxidation on the development in vitro of Plasmodium falciparum in normal and glucose-6-phosphate-dehydrogenase-deficient erythrocytes." Biochemical Journal 236, no. 1 (1986): 97–101. http://dx.doi.org/10.1042/bj2360097.

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Purified aminoaldehydes produced by polyamine oxidation were toxic to the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes. There was a profound effect on young ring forms, and, during maturation, parasites became more sensitive to the aldehydes. Oxidation of the aldehydes abolished the lethal effect. The plasmodia within glucose-6-phosphate-dehydrogenase (G6PD)-deficient erythrocytes were more sensitive to mono- and di-aldehydes than were parasites in normal erythrocytes. G6PD-deficient erythrocytes were also more sensitive to pretreatment with the dialdehyde produced

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11

Gutiérrez-López, Rafael, Josué Martínez-de la Puente, Laura Gangoso, Ramón Soriguer, and Jordi Figuerola. "Plasmodium transmission differs between mosquito species and parasite lineages." Parasitology 147, no. 4 (2020): 441–47. http://dx.doi.org/10.1017/s0031182020000062.

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AbstractFactors such as the particular combination of parasite–mosquito species, their co-evolutionary history and the host's parasite load greatly affect parasite transmission. However, the importance of these factors in the epidemiology of mosquito-borne parasites, such as avian malaria parasites, is largely unknown. Here, we assessed the competence of two mosquito species [Culex pipiens and Aedes (Ochlerotatus) caspius], for the transmission of four avian Plasmodium lineages (Plasmodium relictum SGS1 and GRW11 and Plasmodium cathemerium-related lineages COLL1 and PADOM01) naturally infectin

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12

Mirzaei, Farzaneh, Abolghasem Siyadatpanah, Roghayeh Norouzi, Soheila Pournasir, Veeranoot Nissapatorn, and Maria de Lourdes Pereira. "Blood Parasites in Domestic Birds in Central Iran." Veterinary Sciences 7, no. 3 (2020): 126. http://dx.doi.org/10.3390/vetsci7030126.

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Parasites may affect the dynamics of bird populations. Plasmodium, Leucocytozoon and Haemoproteus are well-known avian haematozoa that can trigger decreased productivity and high mortality in domesticated birds. In this study, we evaluated the prevalence of avian blood parasites (Plasmodium, Leucocytozoon and Haemoproteus) against 335 birds of 8 species in the Yazd province in central Iran. To detect blood parasites, Giemsa-stained blood smears were prepared. Of the birds, 11.64% (39/335) were infected with at least one parasite genus, particularly Haemoproteus (32.6%; 23/335). The total preva

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13

Tebben, Kieran, Salif Yirampo, Drissa Coulibaly, et al. "Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles." PLOS Neglected Tropical Diseases 17, no. 1 (2023): e0010802. http://dx.doi.org/10.1371/journal.pntd.0010802.

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Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum and P. ovale are endemic to Mali and cause clinical malaria, with P. falciparum infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either P. falciparum or P. ovale, and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by

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Matz, Joachim M., Alyssa Ingmundson, Jean Costa Nunes, Werner Stenzel, Kai Matuschewski, and Taco W. A. Kooij. "In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence." Eukaryotic Cell 14, no. 6 (2015): 528–34. http://dx.doi.org/10.1128/ec.00276-14.

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ABSTRACT Malaria pathology is linked to remodeling of red blood cells by eukaryotic Plasmodium parasites. Central to host cell refurbishment is the trafficking of parasite-encoded virulence factors through the Plasmodium translocon of exported proteins (PTEX). Much of our understanding of its function is based on experimental work with cultured Plasmodium falciparum , yet direct consequences of PTEX impairment during an infection remain poorly defined. Using the murine malaria model parasite Plasmodium berghei , it is shown here that efficient sequestration to the pulmonary, adipose, and brain

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15

Kassim, Yasmin M., Feng Yang, Hang Yu, Richard J. Maude, and Stefan Jaeger. "Diagnosing Malaria Patients with Plasmodium falciparum and vivax Using Deep Learning for Thick Smear Images." Diagnostics 11, no. 11 (2021): 1994. http://dx.doi.org/10.3390/diagnostics11111994.

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We propose a new framework, PlasmodiumVF-Net, to analyze thick smear microscopy images for a malaria diagnosis on both image and patient-level. Our framework detects whether a patient is infected, and in case of a malarial infection, reports whether the patient is infected by Plasmodium falciparum or Plasmodium vivax. PlasmodiumVF-Net first detects candidates for Plasmodium parasites using a Mask Regional-Convolutional Neural Network (Mask R-CNN), filters out false positives using a ResNet50 classifier, and then follows a new approach to recognize parasite species based on a score obtained fro

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16

Outlaw, Diana C., and Robert E. Ricklefs. "Rerooting the evolutionary tree of malaria parasites." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13183–87. https://doi.org/10.5281/zenodo.13437998.

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(Uploaded by Plazi for the Bat Literature Project) Malaria parasites ( Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of

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Outlaw, Diana C., and Robert E. Ricklefs. "Rerooting the evolutionary tree of malaria parasites." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13183–87. https://doi.org/10.5281/zenodo.13437998.

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(Uploaded by Plazi for the Bat Literature Project) Malaria parasites ( Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of

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Outlaw, Diana C., and Robert E. Ricklefs. "Rerooting the evolutionary tree of malaria parasites." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13183–87. https://doi.org/10.5281/zenodo.13437998.

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(Uploaded by Plazi for the Bat Literature Project) Malaria parasites ( Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of

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Outlaw, Diana C., and Robert E. Ricklefs. "Rerooting the evolutionary tree of malaria parasites." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13183–87. https://doi.org/10.5281/zenodo.13437998.

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(Uploaded by Plazi for the Bat Literature Project) Malaria parasites ( Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of

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Outlaw, Diana C., and Robert E. Ricklefs. "Rerooting the evolutionary tree of malaria parasites." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13183–87. https://doi.org/10.5281/zenodo.13437998.

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(Uploaded by Plazi for the Bat Literature Project) Malaria parasites ( Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of

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21

Wünsch, Stefan, Cecilia P. Sanchez, Michael Gekle, Lars Große-Wortmann, Jochen Wiesner, and Michael Lanzer. "Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum." Journal of Cell Biology 140, no. 2 (1998): 335–45. http://dx.doi.org/10.1083/jcb.140.2.335.

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Here we describe the identification and characterization of a physiological marker that is associated with the chloroquine-resistant (CQR) phenotype in the human malarial parasite Plasmodium falciparum. Single cell in vivo pH measurements revealed that CQR parasites consistently have an elevated cytoplasmic pH compared to that of chloroquine-sensitive (CQS) parasites because of a constitutively activated Na+/H+ exchanger (NHE). Together, biochemical and physiological data suggest that chloroquine activates the plasmodial NHE of CQS parasites, resulting in a transitory phase of rapid sodium/hyd

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Escalante, A. A., D. E. Freeland, W. E. Collins, and A. A. Lal. "The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome." Proceedings of the National Academy of Sciences of the United States of America 95, no. 14 (1998): 8124–29. https://doi.org/10.5281/zenodo.13532759.

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(Uploaded by Plazi for the Bat Literature Project) We report a phylogenetic analysis of primate malaria parasites based on the gene encoding the cytochrome b protein from the mitochondrial genome. We have studied 17 species of Plasmodium, including 14 parasitic in primates. In our analysis, four species were used for rooting the Plasmodium phylogenetic tree: two from closely related genera (Hepatocystis sp. and Haemoproteus columbae) and two other Apicomplexa (Toxoplasma gondii and Theileria parva). We found that primate malaria parasites form a monophyletic group, with the only exception bein

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Escalante, A. A., D. E. Freeland, W. E. Collins, and A. A. Lal. "The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome." Proceedings of the National Academy of Sciences of the United States of America 95, no. 14 (1998): 8124–29. https://doi.org/10.5281/zenodo.13532759.

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(Uploaded by Plazi for the Bat Literature Project) We report a phylogenetic analysis of primate malaria parasites based on the gene encoding the cytochrome b protein from the mitochondrial genome. We have studied 17 species of Plasmodium, including 14 parasitic in primates. In our analysis, four species were used for rooting the Plasmodium phylogenetic tree: two from closely related genera (Hepatocystis sp. and Haemoproteus columbae) and two other Apicomplexa (Toxoplasma gondii and Theileria parva). We found that primate malaria parasites form a monophyletic group, with the only exception bein

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Galinski, Mary R. "Functional genomics of simian malaria parasites and host–parasite interactions." Briefings in Functional Genomics 18, no. 5 (2019): 270–80. http://dx.doi.org/10.1093/bfgp/elz013.

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AbstractTwo simian malaria parasite species, Plasmodium knowlesi and Plasmodium cynomolgi, cause zoonotic infections in Southeast Asia, and they have therefore gained recognition among scientists and public health officials. Notwithstanding, these species and others including Plasmodium coatneyi have served for decades as sources of knowledge on the biology, genetics and evolution of Plasmodium, and the diverse ramifications and outcomes of malaria in their monkey hosts. Experimental analysis of these species can help to fill gaps in knowledge beyond what may be possible studying the human mal

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Fontinha, Diana, Isabel Moules, and Miguel Prudêncio. "Repurposing Drugs to Fight Hepatic Malaria Parasites." Molecules 25, no. 15 (2020): 3409. http://dx.doi.org/10.3390/molecules25153409.

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Malaria remains one of the most prevalent infectious diseases worldwide, primarily affecting some of the most vulnerable populations around the globe. Despite achievements in the treatment of this devastating disease, there is still an urgent need for the discovery of new drugs that tackle infection by Plasmodium parasites. However, de novo drug development is a costly and time-consuming process. An alternative strategy is to evaluate the anti-plasmodial activity of compounds that are already approved for other purposes, an approach known as drug repurposing. Here, we will review efforts to as

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ISHTIAQ, FARAH, JON S. BEADELL, BEN H.WARREN, and ROBERT C. FLEISCHER. "Diversity and distribution of avian haematozoan parasites in the western Indian Ocean region: a molecular survey." Parasitology 139, no. 2 (2011): 221–31. http://dx.doi.org/10.1017/s0031182011001831.

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SUMMARYThe genetic diversity of haematozoan parasites in island avifauna has only recently begun to be explored, despite the potential insight that these data can provide into the history of association between hosts and parasites and the possible threat posed to island endemics. We used mitochondrial DNA sequencing to characterize the diversity of 2 genera of vector-mediated parasites (Plasmodium and Haemoproteus) in avian blood samples from the western Indian Ocean region and explored their relationship with parasites from continental Africa. We detected infections in 68 out of 150 (45 3%) i

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Smith, Lauren M., Francis C. Motta, Garima Chopra, et al. "An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum." Science 368, no. 6492 (2020): 754–59. http://dx.doi.org/10.1126/science.aba4357.

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The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from red blood cells, which triggers 48-hour fever cycles in the host. This cycle could be driven extrinsically by host circadian processes or by a parasite-intrinsic oscillator. To distinguish between these hypotheses, we examine the P. falciparum cycle in an in vitro culture system and show that the parasite has molecular signatures associated with circadian and cell cycle oscillators. Each of the four strains examined h

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Simão-Gurge, Raquel M., Neha Thakre, Jessica Strickland, et al. "Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host." Biomolecules 11, no. 6 (2021): 807. http://dx.doi.org/10.3390/biom11060807.

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Malaria parasites require pantothenate from both human and mosquito hosts to synthesize coenzyme A (CoA). Specifically, mosquito-stage parasites cannot synthesize pantothenate de novo or take up preformed CoA from the mosquito host, making it essential for the parasite to obtain pantothenate from mosquito stores. This makes pantothenate utilization an attractive target for controlling sexual stage malaria parasites in the mosquito. CoA is synthesized from pantothenate in a multi-step pathway initiated by the enzyme pantothenate kinase (PanK). In this work, we manipulated A. stephensi PanK acti

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Bindschedler, Annina, Jacqueline Schmuckli-Maurer, Rahel Wacker, et al. "Plasmodium berghei-Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival." Cellular Microbiology 2022 (March 12, 2022): 1–17. http://dx.doi.org/10.1155/2022/7647976.

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The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the host cell is crucial for successful completion of liver stage development. Nuclear factor erythroid-derived 2-related factor 2 (NRF2) is a transcription factor known to induce transcription of cytoprotective genes when activated. Here we show that NRF2 is activated in Plasmodium berghei-infected hepatocytes. We observed that this NRF2 activation de

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Slavic, Ksenija, Michael J. Delves, Miguel Prudêncio, et al. "Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle." Antimicrobial Agents and Chemotherapy 55, no. 6 (2011): 2824–30. http://dx.doi.org/10.1128/aac.01739-10.

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ABSTRACTDuring blood infection, malarial parasites used-glucose as their main energy source. ThePlasmodium falciparumhexose transporter (PfHT), which mediates the uptake ofd-glucose into parasites, is essential for survival of asexual blood-stage parasites. Recently, genetic studies in the rodent malaria model,Plasmodium berghei, found that the orthologous hexose transporter (PbHT) is expressed throughout the parasite's development within the mosquito vector, in addition to being essential during intraerythrocytic development. Here, using ad-glucose-derived specific inhibitor of plasmodial hex

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Li, Meizhi Irene, Diyar Mailepessov, Indra Vythilingam, et al. "Prevalence of simian malaria parasites in macaques of Singapore." PLOS Neglected Tropical Diseases 15, no. 1 (2021): e0009110. http://dx.doi.org/10.1371/journal.pntd.0009110.

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Plasmodium knowlesi is a simian malaria parasite currently recognized as the fifth causative agent of human malaria. Recently, naturally acquired P. cynomolgi infection in humans was also detected in Southeast Asia. The main reservoir of both parasites is the long-tailed and pig-tailed macaques, which are indigenous in this region. Due to increased urbanization and changes in land use, there has been greater proximity and interaction between the long-tailed macaques and the general population in Singapore. As such, this study aims to determine the prevalence of simian malaria parasites in loca

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Lisk, Godfrey, and Sanjay A. Desai. "The Plasmodial Surface Anion Channel Is Functionally Conserved in Divergent Malaria Parasites." Eukaryotic Cell 4, no. 12 (2005): 2153–59. http://dx.doi.org/10.1128/ec.4.12.2153-2159.2005.

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ABSTRACT The plasmodial surface anion channel (PSAC), a novel ion channel induced on human erythrocytes infected with Plasmodium falciparum, mediates increased permeability to nutrients and presumably supports intracellular parasite growth. Isotope flux studies indicate that other malaria parasites also increase the permeability of their host erythrocytes, but the precise mechanisms are unknown. Channels similar to PSAC or alternative mechanisms, such as the upregulation of endogenous host transporters, might fulfill parasite nutrient demands. Here we evaluated these possibilities with rhesus

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Jarra, William, and Georges Snounou. "Only Viable Parasites Are Detected by PCR following Clearance of Rodent Malarial Infections by Drug Treatment or Immune Responses." Infection and Immunity 66, no. 8 (1998): 3783–87. http://dx.doi.org/10.1128/iai.66.8.3783-3787.1998.

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ABSTRACT Detection and analysis of pathogens by PCR plays an important role in infectious disease research. The value of these studies would be diminished if nuclear material from dead parasites were found to remain in circulation for extended periods and thus result in positive amplification. This possibility was tested in experimental rodent malaria infections. Blood samples were obtained from infected mice during and following drug or immune clearance of Plasmodium chabaudi chabaudi parasitemias. Detection of parasite DNA by a sensitive Plasmodium-specific PCR amplification assay was associ

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Arisandi, Desto, Sofvirah R. Sohy, and Fitri Nadifah. "Identification of Malaria Parasites in Chasan Boesoirie General Hospital Ternate East Nusa Tenggara." Journal of Health 3, no. 1 (2016): 39. http://dx.doi.org/10.30590/vol3-no1-p39-44.

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Background: Malaria is still a global health problem especially in tropical countries, such as Indonesia. Based on survey 35% of the Indonesia population were live in endemic areas of malaria, such as Provinces of Maluku, North Maluku, Papua, West Papua, North Sumatra, and East Nusa Tenggara. Malaria is caused by a mosquito bite of female Anopheles sp. containing Plasmodium parasite. Generally it bites humans at night or dawn. Such malaria parasites are Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale. Malaria is a disease of both highest in Ternate and mostly

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Atchou, Kodzo, Reto Caldelari, Magali Roques, Jacqueline Schmuckli-Maurer, Raphael Beyeler, and Volker Heussler. "Expanding the fluorescent toolkit: Blue fluorescent protein-expressing Plasmodium berghei for enhanced multiplex microscopy." PLOS ONE 20, no. 3 (2025): e0308055. https://doi.org/10.1371/journal.pone.0308055.

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Fluorescent proteins are widely used as markers to differentiate genetically modified cells from their wild-type counterparts. In malaria research, the prevalent fluorescent markers include red fluorescent proteins (RFPs) and their derivatives, such as mCherry, along with green fluorescent proteins (GFPs) and their derivatives. Recognizing the need for additional fluorescent markers to facilitate multiplexed imaging, this study introduced parasite lines expressing blue fluorescent protein (BFP). These lines enable simultaneous microscopy studies of proteins tagged with GFP, RFP, or detected by

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Antinori, Spinello, Laura Galimberti, Laura Milazzo, and Mario Corbellino. "BIOLOGY OF HUMAN MALARIA PLASMODIA INCLUDING PLASMODIUM KNOWLESI." Mediterranean Journal of Hematology and Infectious Diseases 4, no. 1 (2012): e2012013. http://dx.doi.org/10.4084/mjhid.2012.013.

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Malaria is a vector-borne infection caused by unicellular parasite of the genus Plasmodium. Plasmodia are obligate intracellular parasites that in humans after a clinically silent replication phase in the liver are able to infect and replicate within the erythrocytes. Four species (P.falciparum, P.malariae, P.ovale and P.vivax) are traditionally recognized as responsible of natural infection in human beings but the recent upsurge of P.knowlesi malaria in South-East Asia has led clinicians to consider it as the fifth human malaria parasite. Recent studies in wild-living apes in Africa have reve

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Inyimai, Simon Peter, Mosses Ocan, Benjamin Wabwire, and Peter Olupot-Olupot. "Asymptomatic Plasmodium Parasites among Adults in Eastern Uganda: A Case of Donor Blood Screening at Mbale Regional Blood Bank." Journal of Tropical Medicine 2018 (July 9, 2018): 1–6. http://dx.doi.org/10.1155/2018/6359079.

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Background. There is a paucity of data on asymptomatic carriage of Plasmodium parasite among adult population in Eastern Uganda, an area of perennial high transmission of malaria. In this study, we estimated the prevalence of Plasmodium parasites in donor blood units at Mbale Regional Blood Bank (Mbale RBB), a satellite centre of the Uganda Blood Transfusion Service (UBTS). Method. This was a cross-sectional descriptive study in which 380 screened donor blood units were examined for the presence of Plasmodium parasites. A systematic random sampling technique using the interval of 7 was used in

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Muniz-Junqueira, Maria Imaculada, and Carlos Eduardo Tosta. "Stages of in vitro phagocytosis of Plasmodium falciparum-infected erythrocytes by human monocytes." Revista da Sociedade Brasileira de Medicina Tropical 42, no. 2 (2009): 103–6. http://dx.doi.org/10.1590/s0037-86822009000200001.

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Monocytes/macrophages play a critical role in the defense mechanisms against malaria parasites, and are the main cells responsible for the elimination of malaria parasites from the blood circulation. We carried out a microscope-aided evaluation of the stages of in vitro phagocytosis of Plasmodium falciparum-infected erythrocytes, by human monocytes. These cells were obtained from healthy adult individuals by means of centrifugation through a cushion of Percoll density medium and were incubated with erythrocytes infected with Plasmodium falciparum that had previously been incubated with a pool

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Ramey, A. M., J. A. Reed, J. A. Schmutz, et al. "Prevalence, transmission, and genetic diversity of blood parasites infecting tundra-nesting geese in Alaska." Canadian Journal of Zoology 92, no. 8 (2014): 699–706. http://dx.doi.org/10.1139/cjz-2014-0041.

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A total of 842 blood samples collected from five species of tundra-nesting geese in Alaska was screened for haemosporidian parasites using molecular techniques. Parasites of the genera Leucocytozoon Danilewsky, 1890, Haemoproteus Kruse, 1890, and Plasmodium Marchiafava and Celli, 1885 were detected in 169 (20%), 3 (<1%), and 0 (0%) samples, respectively. Occupancy modeling was used to estimate prevalence of Leucocytozoon parasites and assess variation relative to species, age, sex, geographic area, year, and decade. Species, age, and decade were identified as important in explaining differe

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Frame, I. J., Emilio F. Merino, Vern L. Schramm, María B. Cassera, and Myles H. Akabas. "Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity." Biochemical Journal 446, no. 2 (2012): 179–90. http://dx.doi.org/10.1042/bj20112220.

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Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for subsequent metabolism by the purine salvage pathway. Thus purine transporters are attractive drug targets. All sequenced Plasmodia genomes encode four ENTs (equilibrative nucleoside transporters). During the pathogenic intraerythrocytic stages, ENT1 is a major route of purine nucleoside/nucleobase transport. Another plasma membrane purine transporter exists because Plasmodium falciparum ENT1-knockout parasites survive at supraphysiological

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De Nys, Hélène M., Sébastien Calvignac-Spencer, Ursula Thiesen, et al. "Age-related effects on malaria parasite infection in wild chimpanzees." Biology Letters 9, no. 4 (2013): 20121160. http://dx.doi.org/10.1098/rsbl.2012.1160.

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Wild great apes are widely infected with a number of malaria parasites ( Plasmodium spp.). Yet, nothing is known about the biology of these infections in the wild. Using faecal samples collected from wild chimpanzees, we investigated the effect of age on Plasmodium spp. detection rates. The data show a strong association between age and malaria parasite positivity, with significantly lower detection rates in adults. This suggests that, as in humans, individuals reaching adulthood have mounted an effective protective immunity against malaria parasites.

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Roques, Magali, Annina Bindschedler, Raphael Beyeler, and Volker T. Heussler. "Same, same but different: Exploring Plasmodium cell division during liver stage development." PLOS Pathogens 19, no. 3 (2023): e1011210. http://dx.doi.org/10.1371/journal.ppat.1011210.

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Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication within the host. Successfully invaded sporozoites undergo a massive replication and growth involving asynchronous DNA replication and division that results in the generation of tens of thousands or even hundreds of thousands of merozoites depending on the Plasmodium species. The generation of a high number of daughter parasites requires biogenes

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Devi, Sanasam Bijara, and Sanjeev Kumar. "In-Silico Structural Modeling and Prediction of Conformational B-Cell Epitopes of Potential Vaccine Candidate Pre-Binding Protein." ECS Transactions 107, no. 1 (2022): 15809–16. http://dx.doi.org/10.1149/10701.15809ecst.

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Malaria is a life threatening infectious disease causes by Plasmodium species, wherein Plasmodium falciparum being the most lethal causes severe malaria. Plasmodium parasites have a complex life cycle and employed several immunity evading mechanism that enable the parasite to multiply and survive avoiding the host immunity. The rise in drug-resistant Plasmodium parasites and the unavailability of an effective vaccine lead to major challenges in controlling the parasite. Therefore, it is of utmost important to identify novel potential targets that can be directed for therapeutic intervention. I

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de Angeli Dutra, Daniela, Nayara Belo, and Erika M. Braga. "Prevalence and richness of malaria and malaria-like parasites in wild birds from different biomes in South America." PeerJ 10 (May 19, 2022): e13485. http://dx.doi.org/10.7717/peerj.13485.

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South America has different biomes with a high richness of wild bird species and Diptera vectors, representing an ideal place to study the influence of habitat on vector-borne parasites. In order to better understand how different types of habitats do or do not influence the prevalence of haemosporidians, we performed a new analysis of two published datasets comprising wild birds from the Brazilian Savanna (Cerrado) as well as wild birds from the Venezuelan Arid Zone. We investigated the prevalence and genetic diversity of haemosporidian parasites belonging to two genera: Plasmodium and Haemop

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Dr., Tehmina Hayat Dr. Arshia Maqbool Dr. Muhammad Adnan Akbar. "PREVALANCE OF MALARIA IN EASTERN AREAS OF BALUCHISTAN AT BORDERS OF OTHER PROVINCES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4395–400. https://doi.org/10.5281/zenodo.1254447.

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Objective:<em> The objective of the study was to decide the occurrences of parasites causing malaria in far flung human populations of Balochistan. </em> Methodology:<em> A large group of 3340 subjects was examined for malarial parasites by testing the blood samples during the timeframe of 2 years i.e. July 2015 to June 2017.</em> Results:<em> The laboratory tests revealed that 1095 (32.78%) cases were diagnosed with malaria out of total suspected sample of 3340. Among 1095 infected cases, 579 were due to </em>Plasmodium falciparum<em> infection and 516 cases were infected with </em>Plasmodium

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Dr, Fatima Altaf Dr. Namra Tufail Dr. Shifa Batool. "PREVALANCE OF MALARIA IN EASTERN AREAS OF BALUCHISTAN AT BORDERS OF OTHER PROVINCES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4593–98. https://doi.org/10.5281/zenodo.1257636.

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Objective:<em> The objective of the study was to decide the occurrences of parasites causing malaria in far flung human populations of Balochistan. </em> Methodology:<em> A large group of 3340 subjects was examined for malarial parasites by testing the blood samples during the timeframe of 2 years i.e. July 2015 to June 2017.</em> Results:<em> The laboratory tests revealed that 1095 (32.78%) cases were diagnosed with malaria out of total suspected sample of 3340. Among 1095 infected cases, 579 were due to </em>Plasmodium falciparum<em> infection and 516 cases were infected with </em>Plasmodium

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Sultan, Ali A., Vandana Thathy, Victor Nussenzweig, and Robert Ménard. "Green Fluorescent Protein as a Marker in Plasmodium berghei Transformation." Infection and Immunity 67, no. 5 (1999): 2602–6. http://dx.doi.org/10.1128/iai.67.5.2602-2606.1999.

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ABSTRACT We present a new marker that confers both resistance to pyrimethamine and green fluorescent protein-based fluorescence on the malarial parasite Plasmodium berghei. A single copy of the cassette integrated into the genome is sufficient to direct fluorescence in parasites throughout the life cycle, in both its mosquito and vertebrate hosts. Erythrocyte stages of the parasite that express the marker can be sorted from control parasites by flow cytometry. Pyrimethamine pressure is not necessary for maintaining the cassette in transformed parasites during their sporogonic cycle in mosquito

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Goerdeler, Felix, Peter H. Seeberger, and Oren Moscovitz. "Unveiling the Sugary Secrets of Plasmodium Parasites." Frontiers in Microbiology 12 (July 16, 2021). http://dx.doi.org/10.3389/fmicb.2021.712538.

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Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year. Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far, only small, truncated N- and O-glycans have been identified in Plasmodium species. In contrast, complex glycosylphosphatidylinositol (GPI) glycolipids are highly abundant on the parasite’s cell membrane and are essential for its survival. Moreover, the parasites express lectins that bind and exploit

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"Malaria Parasite Identification using Feature Based Recognition." Issue 4, Volume 5 (June 30, 2020). http://dx.doi.org/10.46243/jst.2020.v5.i3.pp248-250.

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Malaria is one in all the life threatening diseases. Diagnosis of diseases like malaria is very hooked in to the identification of parasites in blood. Various methods are applied for this process. The majority of all method uses machine learning to identify the malarial parasites. This method has shortcomings in long training time and also the must be retrained if a replacement data emerged. Among all of the other various methods that are used, identification using feature based recognition is likely to be rarely used. This method is powerful within the term that it doesn't require training pr

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Su, Xin-zhuan, and Jian Wu. "Zoonotic Transmission and Host Switches of Malaria Parasites." Zoonoses 1, no. 1 (2021). http://dx.doi.org/10.15212/zoonoses-2021-0015.

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Malaria is a deadly disease that affects the health of hundreds of millions of people annually. Five Plasmodium parasite species naturally infect humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, and Plasmodium knowlesi. These parasites can also infect various non-human primates. Parasites mainly infecting monkeys, such as Plasmodium cynomolgi and P. knowlesi, the latter of which was considered to be a monkey parasite for years, can also be transmitted to human hosts. Recently, many new Plasmodium species have been discovered in African apes, some of which

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