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Dissertations / Theses on the topic 'PLATELET AGGREGATION INHIBITORS/analysis'

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Published: 4 June 2021
Last updated: 17 February 2022

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1

Blagojevic, Ana. "An interaction between statins and clopidogrel : a pharmacoepidemiology cohort study with survival time analysis." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112383.

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Clopidogrel is an antiplatelet drug prescribed to prevent stent thrombosis after a percutaneous coronary intervention (PCI). Previous evidence suggests that some widely prescribed statins may inhibit the antiplatelet effects of clopidogrel via competitive metabolism of its activating enzyme cytochrome P450 3A4 (CYP3A4).<br>The objective was to investigate the possibility of an interaction post-PCI between statins and clopidogrel.<br>We carried out a population-based cohort study identifying 10,491 patients using clopidogrel post-PCI (2001-2004). The outcome was a composite of death of any caus
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Lindgren, Peter. "Modeling the economics of prevention /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-352-3/.

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3

Chaves, Áurea Jacob. ""Análise volumétrica da hiperplasia intimal intra-stent em pacientes diabéticos tratados com e sem abciximab"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-09082005-113017/.

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Noventa e seis pacientes com diabetes melito do tipo 2 foram randomizados para receberem ou não abciximab durante o implante eletivo de stent coronário, com o objetivo de determinar se esse inibidor da glicoproteína IIb/IIIa reduz a hiperplasia intimal intra-stent, avaliada pelo ultra-som intracoronário, aos seis meses de evolução. A análise volumétrica mostrou que o abciximab não reduz o volume de obstrução intra-stent nestes pacientes [41,3% (DP21,0%) versus 40,5% (DP18,3%), p=0,853].<br>Ninety-six type 2 diabetics were randomly assigned to receive abciximab or no abciximab at the time of el
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4

Modica, Angelo. "Inflammation, platelet aggregation and prognosis in acute myocardial infarction." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32519.

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5

Wilson, Alasdair. "The effects of combination antiplatelet therapy on smooth muscle mitogenesis after angioplasty for claudication." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165239.

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peripheral arterial disease (PAD), a limiting factor in the success of percutaneous transluminal angioplasty (PTA) is the development of restenosis secondary to vascular smooth muscle cell (SMC) proliferation. The aim of this study was to determine the effect of combination antiplatelet therapy on the ability of plasma, from patients undergoing PTA, to stimulate SMCs in vitro. We aimed to investigate the effect of combination treatment on levels of circulating adhesion molecules and factors which mediate SMC proliferation in experimental models. We also sought to demonstrate any association be
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6

Longmire, Kimberly Ann. "Long-range interactions in mammalian platelet aggregation : evidence from kinetic studies in Browning diffusion and partial characterization using distinct activators, inhibitors and platelet species." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63985.

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7

Coimbra, Leila Santana. "Influência de drogas antiplaquetárias na reparação da doença periodontal experimental em ratos /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/95389.

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Orientador: Luís Carlos Spolidorio<br>Banca: Joni Augusto Cirelli<br>Banca: Raquel Fernanda Gerlach<br>Resumo: O objetivo deste trabalho foi avaliar o efeito da administracao da aspirina (Asp), do clopidogrel (Clo) e da ticlopidina (Tic) sobre o processo de reparacao dos tecidos periodontais apos inducao experimental de periodontite em ratos. Primeiramente avaliou-se a acao destas drogas sobre a expressao das citocinas pro-inflamatorias: TNF-α, IL-6 e TXA2 no tecido gengival de 25 ratos subdivididos em 5 grupos (n=5), 15 dias apos a instalacao da ligadura ao redor do primeiro molar inferior. P
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8

Khalaf, Ali. "Design, synthesis and biological evaluation of new platelet aggregation inhibitors and novel methodologies for the preparation of CF₂R containing molecules." Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00861475.

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The first part of the thesis deals with the synthesis and biological evaluation of new platelets aggregation inhibitors, based on 12-HETE, 13-HODE and their analogues. In the second part we are interested in novel methodologies for the preparation of CF₂-containing molecules : First, a flexible strategy for the synthesis of gem-difluoro-bisarylic derivatives and heteroaromatic analogues was designed based on the easy synthesis and the reactivity of gem-difluoro propargylic intermediates, which by Diels-Alder cycloaddition and 1,3-dipolar cycloadditions afforded respectively the bisarylic and m
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9

Coimbra, Leila Santana [UNESP]. "Influência de drogas antiplaquetárias na reparação da doença periodontal experimental em ratos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/95389.

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Made available in DSpace on 2014-06-11T19:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-20Bitstream added on 2014-06-13T19:35:52Z : No. of bitstreams: 1 coimbra_ls_me_arafo.pdf: 5964104 bytes, checksum: 3c09044b764aa34e6190582152ee354a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O objetivo deste trabalho foi avaliar o efeito da administracao da aspirina (Asp), do clopidogrel (Clo) e da ticlopidina (Tic) sobre o processo de reparacao dos tecidos periodontais apos inducao experimental de periodontite em ratos. Primeiramente avaliou-se a aca
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10

Figueiredo, Mariana Nogueira de [UNESP]. "Efeito da inibição da ativação plaquetária durante o desenvolvimento da doença periodontal em ratos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/96178.

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Made available in DSpace on 2014-06-11T19:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-24Bitstream added on 2014-06-13T20:36:52Z : No. of bitstreams: 1 figueiredo_mn_me_arafo.pdf: 505100 bytes, checksum: eada950ead77995efc3596398acffd43 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>O objetivo deste trabalho foi avaliar o efeito da administração da aspirina (AAS), do clopidogrel (Clo) e da ticlopidina (Tic) sobre a evolução da periodontite experimental em ratos. Cinquenta ratos (Rattus norvegicus albinus, Holtzman) foram distribuídos aleat
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11

Camacho, Londoño Juan Eduardo [Verfasser], and Peter [Akademischer Betreuer] Lipp. "Role of TRPC-channels in cardiac hyperthrophy and platelet aggregation : Analysis of TRPC-deficient mice / Juan Eduardo Camacho Londoño. Betreuer: Peter Lipp." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052557295/34.

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12

Fornari, Luciana Savoy. ""Fibrilação atrial e tratamento antitrombótico em pacientes atendidos em hospital especializado em cardiologia no Brasil"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-13042006-120958/.

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Objetivo: Avaliar o uso de antitrombóticos em pacientes com fibrilação atrial (FA) em hospital cardiológico no Brasil (InCor).Métodos e resultados: Um estudo observacional transversal analisou os prontuários de todos os pacientes atendidos no InCor em cada um de 5 dias separados no ano de 2002 (Fase 1), sendo prospectivamente reanalisados após 1 ano (Fase 2). A prevalência da FA nos 3764 prontuários analisados foi de 8%. Antiplaquetários foram prescritos para 21,26% e 19,93%, anticoagulantes para 46,51% e 57,81%, e 32,23% e 22,26% não usavam nenhum antitrombótico nas Fases 1 e 2, respectivamen
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13

Figueiredo, Mariana Nogueira de. "Efeito da inibição da ativação plaquetária durante o desenvolvimento da doença periodontal em ratos /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/96178.

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Orientador: Luis Carlos Spolidorio<br>Banca: Joni Augusto Cirelli<br>Banca: Claudia Maria Coelho Alves<br>Resumo: O objetivo deste trabalho foi avaliar o efeito da administração da aspirina (AAS), do clopidogrel (Clo) e da ticlopidina (Tic) sobre a evolução da periodontite experimental em ratos. Cinquenta ratos (Rattus norvegicus albinus, Holtzman) foram distribuídos aleatoriamente em 5 grupos (n=10), sendo 1 controle e 4 submetidos à periodontite através da instalação de ligadura bilateral na região de primeiro molar inferior. Os ratos submetidos à periodontite experimental foram tratados com
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14

Borges, Juliana Maria Dantas Mendonça. "Antiagregantes plaquetários em perioperátorio de cirurgias não cardíacas e a tomada de decisão entre manter ou suspender." Pós-Graduação em Ciências da Saúde, 2018. http://ri.ufs.br/jspui/handle/riufs/8896.

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Antiplatelet agents in the perioperative period of non-cardiac surgeries and the decision making between maintaining or suspending.Juliana Maria Dantas Mendonça Borges.2018 INTRODUCTION: In daily clinical practice there is the dilemma between maintaining or suspending antiplatelet agents in the perioperative period of non-cardiac surgeries. OBJECTIVES: To describe the prescribing pattern of antiplatelet agents in the perioperative period of noncardiac surgeries. METHODS: A cross-sectional study was carried out from October 2014 to October 2016 in a hospital. The study-dependent variable was t
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15

Filho, José Ronaldo Mont\'Alverne. "Efeito dos novos antiagregantes plaquetários prasugrel e ticagrelor administrados upstream sobre os achados angiográficos da angioplastia primária." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-27102015-113637/.

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Introdução. A dupla antiagregação plaquetária traz benefícios no tratamento do infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAMSST). Há variabilidade intra e interindividual no uso do clopidogrel e isso influencia no benefício do seu uso nesse grupo de pacientes. O objetivo desta pesquisa foi avaliar os efeitos de novo antiagregantes plaquetários (prasugrel e ticagrelor) administrados na sala de emergência (\"upstream\") sobre o resultado angiográfico da angioplastia primária, levando em conta o fluxo coronariano TIMI, o blush miocárdico e a carga de trombo. Métodos. Foi
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16

Fontenele, Juvenia Bezerra. "Estudo farmacolÃgico da fraÃÃo hexÃnica de Lonchocarpus sericeus (Poir) Kunth e seus constituintes quÃmicos, lonchocarpina e derricina." Universidade Federal do CearÃ, 2004. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=33.

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FundaÃÃo de Amparo à Pesquisa do Estado do CearÃ<br>CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O gÃnero Lonchocarpus à bastante conhecido e amplamente estudado, porÃm nÃo hà registros na literatura cientÃfica dos usos farmacolÃgicos da espÃcie Lonchocarpus sericeus (Poir.) Kunth, (Leguminosae Papilionaceae). Estudos quÃmicos demonstraram que a fraÃÃo hexÃnica das cascas das raÃzes de L. sericeus (FLS) à rica nas chalconas: lonchocarpina (LCC) e derricina (DRC). O objetivo deste trabalho foi investigar os efeitos tÃxicos e as aÃÃes farmacolÃgicas da FLS e de sua chalconas LC
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17

Lin, Yi-Tang, and 林義棠. "Analysis of inhibitory effects of nature products on beta-amyloid fibril-induced platelet aggregation." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/fgy46n.

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碩士<br>國立陽明大學<br>藥理學研究所<br>97<br>Recent studies indicate that there are many vasculopathy diseaes may be related to platelet. One of the major features of diseases is the β-amyloid (Aβ) peptides, which are deposited and aggregated as the senile plaques in brains of Alzheimer's disease (AD) individuals. The Aβ fibrils are not only critical to the etiology of AD but also play a key role in the pathogenesis of cerebral amyloid angiopathy. It has been known that platelets are an important cellular element in vasculopathy of various causes. Many studies demonstrate that Aβ fibrils can activate plate
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18

"Model study and partial synthesis of prehispanolone and derivatives from hispanolone." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5895462.

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En Si Wang.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 126-140 (2nd gp.)).<br>Acknowledgements --- p.i<br>Contents --- p.ii<br>Abstract --- p.iv<br>List of Acronyms and Abbreviations --- p.vi<br>introduction --- p.1<br>Chapter I. --- "Platelet Activating Factor (PAF)´ؤPast, Present, and Future" --- p.1<br>Chapter I-1. --- What is PAF? --- p.1<br>Chapter I-2. --- Biochemistry of PAF --- p.2<br>Chapter I-2-1. --- Metabolic Cycle of PAF --- p.3<br>Chapter I-2-1-A. --- Biosynthesis of PAF --- p.4<br>Chapter I-2-1 -B. --- Inact
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19

HUANG, YU-BIN, and 黃裕斌. "Molecular cloning and nucleotide sequence analysis of the cDNA of a platelet aggregation inhibitor from the snake venom of calloselasma rhodostoma." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/76951182134446443513.

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碩士<br>國立陽明大學<br>遺傳學研究所<br>79<br>Rhodostomin 是從馬來亞腹蛇Calloselasmarhodostoma的毒液中純化出來的勝踽，由 68個胺基酸組成，含六對雙硫鍵，具有抗血小板凝集的功能。本論文根據rhodostom- in的部分胺基酸序列，合成一組混合式寡核甘酸作為探針，從該蛇毒腺細胞之mRNA所 建立之 gtll cDNA 基因庫中篩選出一個選殖體，經聚合繪連鎖反應(PCR) ，將插入 片段擴增出來，其產物以5'端標示上 P 的混合寡核甘酸為端子, 直接定其澗基序列 。靠近端子附近的澗基序列轉譯后與已知rhodostomin 的部分胺基酸序列完全一致， 故證實已獲得之選殖體是正確的。再以該cDNA為探針，在10萬個溶菌斑中取得30個陽 性選殖體，其中5 個選殖體經選殖和定序后，發現互有重詁。組合其中兩個cDNA序列 其得1,855bp 之總長。分析此組合澗基序列，發現一讀框(ORF) ，轉譯后可得459 個 胺基酸序列之勝踽，其C 端包含了完整的rhodostomin
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20

Liu, Fu Chao, and 柳復兆. "The effects of Sirtuin inhibitors on platelet aggregation and hemorrhagic shock." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/31788456072211222192.

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博士<br>長庚大學<br>臨床醫學研究所<br>97<br>ABSTRACT Sirtuin inhibitors (sirtinol, splitomicin) are cell-permeable lactone derived from β-naphthol, Which are the potent selectively inhibitor of Sir2 (silent information regulator 2) enzyme. Previous studies have demonstrated that some naphthoic compounds possess an inhibitory effect on platelets and anti-inflammatory effect on neutrophils. Therefore, their naphthoic moiety might be responsible for their inhibitory effects on platelet aggregation and attenuation injury effect on hemorrhagic shock. The major aims of our studies were to examine possible mec
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21

"Pharmacological characterization of prehispanolone, a PAF receptor antagonist." Chinese University of Hong Kong, 1991. http://library.cuhk.edu.hk/record=b5886915.

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by Chu, Pui-ya.<br>Thesis (M.Phil.)--Chinese University of Hong Kong.<br>Bibliography: leaves 115-126.<br>ACKNOWLEDGEMENT<br>LIST OF ABBREVIATIONS<br>ABSTRACT --- p.1<br>Chapter CHAPTER 1 --- INTRODUCTION<br>Chapter 1.1 --- PLATELET-ACTIVATING FACTOR (PAF) --- p.4<br>Chapter 1.1.1 --- Metabolism of PAF --- p.4<br>Chapter 1.1.1.1 --- Biosynthesis of PAF --- p.4<br>Chapter 1.1.1.2 --- Degradation of PAF --- p.9<br>Chapter 1.1.2 --- Systemic effects of PAF --- p.12<br>Chapter 1.1.3 --- Structure - activity relationship of PAF --- p.16<br>Chapter 1.2 --- PAF RECEPTORS --- p.19<br>Chapter 1
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22

"Synthetic studies of prostacyclin receptor antagonists." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5887737.

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by William, Wai-lun Lam.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 85-95).<br>Chapter I. --- Introduction --- p.1<br>Chapter II. --- Our Approach --- p.9<br>Chapter III. --- Results and Discussion - Synthetic Strategy --- p.29<br>Chapter IV. --- Results and Discussion - Pharmacological Activity --- p.44<br>Chapter V. --- Conclusion --- p.49<br>Chapter VI. --- Further Development --- p.53<br>Chapter VII. --- Experimental Section --- p.55<br>Chapter VIII. --- References --- p.85<br>Chapter IX. --- Supplementary Materials --
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23

Roberts, Wayne, S. Magwenzi, Ahmed Aburima, and Khalid M. Naseem. "Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade." 2010. http://hdl.handle.net/10454/6155.

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Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet function at sites of vascular injury. Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism. Prostaglandin E(1) (PGE(1)) induced a robust inhibition of both platelet aggregation and platelet arrest under physiologic conditions of flow. Exogenous TSP-1 reduced significantly PGE(1)-mediated inhibition of both platelet aggregation and platelet arrest. TSP-1 prevented PGE(1)-stimulated cAMP accrual and phosphorylation of PKA substrates, through a mecha
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