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Dissertations / Theses on the topic 'Platelet disorder'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Neuger, Jolanta. "Platelet serotonin function and personality traits in affective disorder /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-181-0.

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2

Beutler, Lucinda. "Platelet and erythrocyte functional defects caused by mutations of GFI1B." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20481.

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GFI1B is a transcriptional repressor that is a major regulator of megakaryocytic and erythroid differentiation and development. The cause of a bleeding disorder in a four- generation Australian family, with cell changes consistent with aberrant platelet structure and function, and red blood cell morphology, showing autosomal dominant inheritance, was identified as being caused by a single nucleotide insertion into the GFI1B gene (c.880_881insC). The aims of this thesis were to study the effects of this mutant GFI1B on erythrocyte development in a cell culture model; to study how loss of Gfi1b

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3

Norazit, Anwar. "Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF) in a Novel Model of Parkinson's Disease." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366312.

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Parkinson’s disease is a progressive neurodegenerative disorder, characterised histopathologically by the degenerating nigrostriatal pathway. Previous studies have shown a decrease in neurogenesis, dopaminergic neurons and neurotrophic factor levels in the Parkinson brain. This thesis investigates the capability of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) to stimulate endogenous neurogenesis and offer direct or indirect neuroprotection in a novel model of Parkinson’s disease. To assess the neurogenic capability of the postnatal substantia nigra, the e

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4

Sampaio, Thiago Pacheco de Almeida. "Relação entre a concentração de serotonina no plasma rico em plaquetas e a resposta à terapia comportamental baseada em exposição com prevenção de resposta no transtorno obsessivo-compulsivo." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-20022009-141000/.

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INTRODUÇÃO: Entre os tratamentos existentes para o transtorno obsessivocompulsivo (TOC) os mais eficazes são o farmacológico, com inibidores de recaptura de serotonina (IRS; inibidores seletivos de recaptura de serotonina [ISRS] e clomipramina), e o comportamental, baseado na técnica de exposição com prevenção de resposta (EPR). Ambas apresentam eficácia semelhante para os sintomas obsessivo-compulsivos e estudos demonstram que a EPR produz modificações neurobiológicas semelhantes às provocadas pelo tratamento com ISRS. Essas evidências sugerem que a resposta clínica à EPR está diretamente rel

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5

Cai, Huili. "Diagnostic des pathologies plaquettaires : optimisation de l'exploration des granules denses plaquettaires." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0067/document.

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Les plaquettes sont les cellules principales de l’hémostase. Leur anomalie qualitative et/ou quantitative est à l’origine d’une diathèse hémorragique. Le diagnostic des anomalies plaquettaires nécessite des tests biologiques. L’objectif de notre travail a été d’améliorer leur diagnostic, en particulier, de développer de nouveaux outils d’exploration des granules denses plaquettaires. Les pathologies plaquettaires héréditaires sont mal connues en Chine. Donc la cadre de notre collaboration Nancy /Wuhan nous avons publié un article en Chinois sur les thrombopénies héréditaires. Ensuite, nous avo

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6

Lynch, Susan Fraser. "Platelet and vascular studies in myeloproliferative disorders." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/24860.

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We have studied a cohort of patients with polycythaemia vera (PV) primary thrombocythaemia (PT) and primary myelofibrosis (PMF) and described their clinical and laboratory features in comparison to other published observations. The demographic, haematological and molecular characteristics of our cohort were similar to other retrospective analyses, but the occurrence of thrombo-haemorrhagic complications was lower. The presence of vascular abnormalities in these patients was investigated using both established markers and an assay was devised to measure platelet, endothelial, leucocytes and red

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7

Longato-Stadler, Eva. "Psychopathology and Platelet MAO in a Criminal Male Population in Sweden." Doctoral thesis, Uppsala University, Department of Neuroscience, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2028.

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<p>The subjects were 130 male prisoners in Swedish jails were examined by SCID and the diagnoses given in terms of DSM-IV. The most common mental disorder was drug abuse. On Axis II several personality disorders were diagnosed. Personality assessments were made by KSP. High scores were mainly found for e.g. impulsiveness, sensation seeking, aggression and low scores in socialisation.</p><p>MAO assays were performed in 99 male criminal offenders and in 60 non-criminal volunteers. Offenders had lower MAO activity than controls also with the confounding factor smoking under control. It is propo

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8

Al, Ghaithi Rashid Hafidh Rashid. "Laboratory investigation of platelet function in patients with mild bleeding disorders." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8173/.

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Platelets play a crucial role in haemostasis by preventing bleeding at sites of vascular injury. Inherited or acquired platelet defects can impair haemostasis resulting in bleeding symptoms of varying severity ranging from mild to excessive which can be life threatening. Diagnosis of mild platelet-based bleeding disorders is challenging due to the absence of a gold standard technique and their variable bleeding symptoms and bleeding phenotypes observed in healthy individual as well as other haemostatic disorders. The work in this thesis built on the previous studies in the genotyping and plate

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9

Gurney, David Andrew. "Development and implementation of regional platelet diagnostic laboratory in order to enhance the diagnosis and treatment of inherited platelet function disorders." Thesis, University of Portsmouth, 2012. https://researchportal.port.ac.uk/portal/en/theses/development-and-implementation-of-regional-platelet-diagnostic-laboratory-in-order-to-enhance-the-diagnosis-and-treatment-of-inherited-platelet-function-disorders(d2bf09b6-16c1-4dcb-8eaa-61c3167d9fc9).html.

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This project sets out to create a reference laboratory service capable of detecting platelet function disorders using the latest techniques and based on the most current research. Platelet function disorders are difficult to diagnose due to differing phenotypic presentation and multiple causative agents. Platelet research has moved rapidly over the past decade and has included new reagents, analysers and techniques in the way platelet function disorders are diagnosed. A forward-looking diagnostic laboratory needs translate this ongoing research into routine laboratory practice, whilst ensuring

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10

Taylor, James Michael. "Validation of a new method for platelet HPA-1 phenotyping." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1133736.

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Polymorphisms of platelet glycoproteins (GPs) are frequently targets for anti-platelet antibodies. At least 19 antigenic polymorphisms have been identified on platelet GPs. Antibodies against the HPA-lb polymorphism (a Leu to Pro switch at amino acid residue 33 of the IIIa sub-unit of GP IIb/Illa) have been attributed to as much as 90% of all cases of neonatal alloimmune thrombocytopenic purpura and posttransfusion purpura in caucasians. The HPA-lb polymorphism has also been equivocally associated with coronary artery disease, particularly early onset (<60 years of age) myocardial infarction.

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11

Crossley, Alison Rachel. "Immunological parameters in immune thrombocytopenic purpura and the effects of alpha interferon therapy." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308323.

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12

Knöfler, Ralf, and Werner Streif. "Strategies in Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders in Children." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136597.

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Inherited disorders of platelet function are a rare and heterogeneous group of diseases usually characterised by a mild to moderate bleeding tendency. Typical bleeding symptoms are easy bruising, epistaxis, menorrhagia as well as mucocutaneous and perioperative bleeding. The performance of platelet function diagnostics in children is hampered by age-dependent restriction of blood sample size, poor venous access, and the lack of reproducible test reference ranges for children of different age groups. Platelet function testing is limited to specialised centres, because platelet function test pro

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13

Knöfler, Ralf, and Werner Streif. "Strategies in Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders in Children." Karger, 2010. https://tud.qucosa.de/id/qucosa%3A27716.

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Inherited disorders of platelet function are a rare and heterogeneous group of diseases usually characterised by a mild to moderate bleeding tendency. Typical bleeding symptoms are easy bruising, epistaxis, menorrhagia as well as mucocutaneous and perioperative bleeding. The performance of platelet function diagnostics in children is hampered by age-dependent restriction of blood sample size, poor venous access, and the lack of reproducible test reference ranges for children of different age groups. Platelet function testing is limited to specialised centres, because platelet function test pro

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14

Bariana, Tadbir Kaur. "Discovery of novel variants underlying inherited bleeding and platelet disorders by next generation sequencing." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10061367/.

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Genetic variants that affect megakaryopoiesis and platelet formation result in inherited bleeding and platelet disorders (BPD). Only 40-60% of cases will receive a diagnosis indicating the pathway at fault [1, 2]. This thesis is the result of work undertaken to discover novel variants causative of BPD, as part of the NIHR BioResource-Rare Diseases Study (NIHR BR-RD). 1,213 BPD cases of uncertain genetic aetiology were recruited from 31 international centres. 687 samples were sent for whole exome sequencing and 1118 for whole genome sequencing. Cases were systematically phenotyped and genotype-

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15

Donada, Alessandro. "Physiopathological mechanisms of two congenical platelet disorders : filaminopathy-A and ANKRD26-related - Thrombocytopenia 5THC2." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/DONADA_Alessandro_2_complete_2018.zip.

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Les thrombopénies héréditaires sont une classe de maladies hématologiques congénitaux affectant principalement la lignée mégacaryocytaire. Elle s’accompagnant d'une diminution du nombre de plaquettes. Près de 50 gènes différents ont été associés à des thrombopénies héréditaires, et d'énormes différences existent entre chaque maladie, en ce qui concerne la manifestation clinique et la pathobiologie. Mes recherches ont porté sur deux thrombopénies héréditaires différentes: Filaminopathie A et THC2. La première maladie est un syndrome X-linked, associé à des mutations dans le gène FLNA (Filamine

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16

Joaquim, Helena Passarelli Giroud. "Proteômica da esquizofrenia: busca por biomarcadores em plaquetas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-09042018-095856/.

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Esquizofrenia é um transtorno psiquiátrico complexo que afeta cerca de 1% da população mundial. Apesar de progressos consideráveis nos últimos anos, a etiologia da doença ainda não foi elucidada principalmente pela heterogeneidade tanto do início quanto da progressão da doença. Frequentemente os sintomas dos pacientes são comuns a outras desordens neuropsiquiátricas, dificultando a diferenciação por meio de métodos essencialmente clínicos. Por isso, pesquisadores têm tentado identificar medidas baseadas em características moleculares que justifiquem e expliquem a etiologia da esquizofrenia. Já

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17

Sánchez, Guiu Mª Isabel. "Caracterización funcional y molecular de trombopatías congénitas= Functional and molecular characterization of inherited platelet disorders." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/284814.

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Introducción Los trastornos plaquetarios congénitos son un grupo heterogéneo de enfermedades raras que se caracterizan por alterar la producción/función plaquetaria, dando lugar a diátesis hemorrágica. A pesar de que estas enfermedades son muy conocidas, la identificación temprana y la caracterización de los pacientes sigue siendo difícil debido a la heterogeneidad clínica y de laboratorio; la falta de especificidad y la complejidad de los ensayos de la función plaquetaria; el gran número de genes causales; y la ausencia de correlación genotipo-fenotipo. Los proyectos multicéntricos sobre esto

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18

Poles, A. "Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy." Thesis, University of the West of England, Bristol, 2013. http://eprints.uwe.ac.uk/22243/.

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The archetypical inherited platelet (PLT) disorders are Glanzmann’s Thrombasthenia (GT) and Bernard Soulier Syndrome (BSS) and both are autosomal recessive disorders. GT results from mutations in the ITGB3 and/or ITGA2B genes that encode the GPIIb/IIIa complex, while BSS results from mutations in the genes (GPIba, GPIbb and GPIX) that encode the GPIb/IX/V complex. GT and BSS patients have a mild bleeding tendency which is in contrast with patients with another inherited PLT disorder known as congenital amegakaryocytic thrombocytopenia (CAMT). CAMT is associated with mutations in the MPL gene t

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19

Westmoreland, D. A. "Lysosome-related organelles : an investigation into clinical disorders of endothelial cells and platelets." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1561240/.

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Lysosome-related organelles (LROs) are a heterogeneous group of organelles that have important functions in a number of specialised cell types. LROs, despite their distinct features and morphology, have been grouped together due to the observation that they are simultaneously functionally perturbed by single mutations in a number of genetic disorders, yet as a group they are still poorly understood. Firstly, it was investigated whether the genes that are important for the formation/maturation of other LROs can also affect Weibel-Palade bodies (WPBs) an endothelial LRO that is critical to haemo

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20

Cheng, Xi. "Prevalence, profile, predictors, and natural history of aspirin resistance measured by the ultegra rapid platelet function assay-asa in patients with coronary artery disease." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B33708708.

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21

Chou, Ming-Li. "Dedicated, virally-inactivated, platelet lysates and platelet microparticles in regenerative medicine and neuroprotective therapies." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S040/document.

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Garantir la qualité des produits sanguins est crucial. Les lysats plaquettaires (LP) riches en facteurs de croissance (FC) s’imposent comme le complément idéal pour l’expansion ex vivo des cellules souches, et comme produit thérapeutique pour la régénération cellulaire. L’intérêt est croissant pour les microparticules (MPs) extracellulaires, mais l’expression de phosphatidylsérine à leur surface peut induire des effets thrombotiques et inflammatoires. L’autre risque transfusionnel, la transmission de virus, dont le virus de l’hépatite C (VHC), est maîtrisable par traitements de réduction viral

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22

Stritt, Simon [Verfasser], Bernhard [Gutachter] Nieswandt, Antje [Gutachter] Gohla, and Manfred [Gutachter] Gessler. "The role of the cytoskeleton in platelet production and the pathogenesis of platelet disorders in humans and mice / Simon Stritt ; Gutachter: Bernhard Nieswandt, Antje Gohla, Manfred Gessler." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1148279660/34.

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23

Ikenaga, Eliza Hiromi. "Atividade da fosfolipase A2 no transtorno bipolar." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-14082013-101930/.

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Alteração da fosfolipase A2 tem sido descrita em diversas doenças neuropsiquiátricas. Esta enzima é responsável pelo metabolismo dos fosfolípides de membrana e parece estar envolvida na fisiopatologia do transtorno bipolar. Neste estudo, foram analisados os três principais subtipos da PLA2 (sPLA2, cPLA2 e iPLA2) em plaquetas de pacientes e indivíduos controles. A atividade de subtipos de PLA2 foi determinada em 20 pacientes TB sem tratamento com estabilizadores de humor e após seis semanas de tratamento com lítio; 72 pacientes medicados e 65 controles (16 pareados com os pacientes sem tratamen

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24

Nkambule, Bongani Brian. "Platelet flow cytometry and coagulation tests as markers of immune activation in chronic HIV infection." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20373.

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Thesis (MScMedSc)--Stellenbosch University, 2012.<br>Bibliography<br>ENGLISH ABSTRACT: Background: In the era of antiretroviral therapy (ART), the risk of acquired immune deficiency syndrome (AIDS) related deaths has decreased and people living with Human Immunodeficiency Virus (HIV) now have prolonged life spans. However, an increasing trend of non-AIDS associated deaths has been reported despite adequate control of viral loads. HIV infection is established as a chronic inflammatory condition which is associated with an increased risk for thrombosis. Thus HIV infected patients are at a h

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25

Dawood, Ban Behnam. "Study of patients with suspected platelet-based bleeding disorders : a search for patients with a defect in the P2Y12 ADP receptor." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1519/.

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Mild platelet-based bleeding disorders are among the most complex bleeding disorders to understand, due to the absence of a ‘gold standard’ test for diagnosis and the significant overlap with the bleeding phenotype observed in healthy individuals. The work in this thesis is focussed on patients with a clinically diagnosed mild platelet disorder for which no acquired cause was identified by the referring expert clinician. ADP and thromboxane A2 (TxA2) are key secondary mediators of platelet aggregation and function in synergy to facilitate robust platelet activation in the event of vascular dam

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26

Cheng, Xi, and 程曦. "Prevalence, profile, predictors, and natural history of aspirin resistance measured by the ultegra rapid platelet function assay-asain patients with coronary artery disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B33708708.

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27

Souza, Paula Fontoura Coelho de. "Doenças cardiovasculares em pacientes bipolares: uma investigação da biodisponibilidade do óxido nítrico." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9119.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Os transtornos psiquiátricos são um problema de saúde pública, ocupando cinco das dez principais causas de incapacitação no mundo. O transtorno bipolar (TB) é um transtorno de humor, segundo o DSM-IV (manual diagnóstico e estatístico de doenças mentais), o qual afeta cerca de 1% da população mundial. O TB do tipo I (TBI) é o mais frequente entre os TBs e é caracterizado pela presença de episódios maníacos ou mistos acompanhados por episódios depressivos. Assim como outros transtornos psiquiátricos, como a depressão, ansiedade e esq

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Joaquim, Helena Passarelli Giroud. "Serotonina e glicogênio sintase quinase 3B em plaqueta de pacientes idosos com transtorno depressivo maior: efeito do tratamento com sertralina." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-19032012-090928/.

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A depressão é o mais comum dos distúrbios afetivos. Afeta ao menos 10% da população idosa do Brasil. Nos idosos, alguns fatores ligados ao metabolismo parecem estar bastante relacionados a esse transtorno, como uma menor concentração de noradrenalina e serotonina (5-HT) e uma maior atividade da monoaminooxidase em relação a adultos jovens. Os inibidores seletivos da recaptação da serotonina (ISRS), principalmente a sertralina, são a primeira opção no tratamento da fase aguda e manutenção dos episódios depressivos em idosos. As plaquetas vêm sendo amplamente utilizadas como modelo para estudar

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29

Simanauskas, Kazys. "Paauglių pirminės arterinės hipertenzijos sąsajos su fizine ir psichine sveikata bei širdies ir kraujagyslių ligų rizikos veiksniais." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130916_082410-88506.

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Moksliniais tyrimais nustatyta, kad širdies ir kraujagyslių sistemos ligų rizikos veiksniai atsiranda jau vaikystėje. Arterinė hipertenzija – vienas pagrindinių širdies ir kraujagyslių sistemos ligų rizikos veiksnių, neretai pasireiškia jau paauglystėje. Padidėjęs arterinis kraujo spaudimas, ilgainiui pažeidžia organus taikinius: kraujagysles, širdį, smegenis, inkstus, akis. Todėl nepavėluotam gydymui užtikrinti vis aktualesnė tampa ankstyva AH diagnostika, kuri leistų sumažinti ligos progresavimą, pailginti laiką iki komplikacijų pasireiškimo ir užtikrinti geresnę gyvenimo kokybę, nes sveikat

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30

Dupuis, Arnaud. "Diagnostic biologique, caractérisation moléculaire et identification de nouveaux gènes impliqués dans des thrombopathies congénitales non étiquetées." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ078/document.

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Les thrombopathies congénitales sont des pathologies au phénotype hémorragique hétérogène dues à des anomalies fonctionnelles des plaquettes sanguines parfois associées à des anomalies morphologiques et/ou à une thrombopénie. Les outils diagnostic disponibles permettent de corréler une anomalie fonctionnelle plaquettaire à un déficit protéique voire à une mutation d’un gène spécifique. Cependant, en 2015, au moins 50% des thrombopathies restent non étiquetées. Dans ce contexte, le laboratoire d’hémostase de l’EFS Alsace et l’unité INSERM UMR S949 travaillent de concert à l’identification et à

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Zainaghi, Isis Amaral. "Fosfolipase A2, fluidez de membrana e proteína precursora do amilóide em plaquetas na doença de Alzheimer e comprometimento cognitivo leve." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-03052007-093430/.

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A Doença de Alzheimer (DA) é uma desordem neurodegenerativa progressiva que causa comprometimento cognitivo em idosos. O diagnóstico clínico da DA é complexo. Existe uma grande necessidade de técnicas capazes de detectar a doença nos estágios iniciais, tanto para auxiliar o diagnóstico quanto para monitorar a efetividade dos tratamentos disponíveis. As alterações bioquímicas da DA são resultado de processos celulares como o metabolismo da proteína precursora do amilóide (APP), fosforilação da tau, stress oxidativo, inflamação e desregulação lipídica. Até o momento não existem marcadores bioquí

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32

Hernández, Enríquez Marco. "Transcatheter Aortic Valve Implantation: Moving Forward to Minimize Vascular and Bleeding Complications = Implante Transcatéter de Válvula Aórtica: Avanzando hacia la Reducción de Complicaciones Vasculares y Hemorrágicas." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/669896.

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INTRODUCTION: TAVI has settled as the standard of care of AS for inoperable, high-risk, and selected intermediate-risk patients undergoing aortic valve replacement. Vascular and bleeding complications are related to worst outcomes. HYPOTHESES: a. The reduction and early recognition of vascular and bleeding complications might improve clinical outcomes in patients treated with TAVI. b. A full percutaneous transfemoral approach for TAVI is related to a lower rate of major bleedings in comparison to the surgical cut-down approach. c. The development of post-TAVI thrombocytopenia has a pr

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Sigitova, Ekaterina. "Psychopathology, mental disorders and mitochondrial disorders." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-370965.

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This study investigates the connection between different pathophysiological processes in mitochondria and psychopathological symptoms in patients with bipolar disorder. Changes in activity of selected components of the respiratory chain and overall respiratory rate of mitochondria were analyzed in patients with bipolar disorder when compared to healthy controls. Diagnostic scales and questionnaires, high-resolution respirometry, radiochemical and spectroscopic methods were used. 37 patients with a diagnosis of bipolar disorder (F31) and 21 healthy volunteers were involved in the study. Statist

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34

Duchon, Theresa A. "The effects of preeclampsia and magnesium sulfate (MgSO₄)on platelet function a secondary analysis : [thesis submitted] in partial fulfillment ... for [degree of Master of Science in Nursing] Nursing 699 /." 1995. http://catalog.hathitrust.org/api/volumes/oclc/68798729.html.

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35

Jürgensen, Brigitte. "Die Wirkung von niedrig dosiertem Desmopressin auf die durch Acetylsalicylsäure verlängerte Blutungszeit." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AF7E-6.

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36

Stritt, Simon. "The role of the cytoskeleton in platelet production and the pathogenesis of platelet disorders in humans and mice." Doctoral thesis, 2017. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-122662.

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Platelets are continuously produced from megakaryocytes (MK) in the bone marrow by a cytoskeleton-driven process of which the molecular regulation is not fully understood. As revealed in this thesis, MK/ platelet-specific Profilin1 (Pfn1) deficiency results in micro- thrombocytopenia, a hallmark of the Wiskott-Aldrich syndrome (WAS) in humans, due to accelerated platelet turnover and premature platelet release into the bone marrow. Both Pfn1-deficient mouse platelets and platelets isolated from WAS patients contained abnormally organized and hyper-stable microtubules. These results reveal an u

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37

Moutinho, Joana Filipa Monteiro. "Platelet-Rich plasma in the tissue healing process of patients with bleeding disorders." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/75749.

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38

Moutinho, Joana Filipa Monteiro. "Platelet-Rich plasma in the tissue healing process of patients with bleeding disorders." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/75749.

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