Relevant bibliographies by topics / Platelet dynamics

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Platelet dynamics'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "Platelet dynamics"

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Rinder, HM, JL Bonan, CS Rinder, KA Ault, and BR Smith. "Dynamics of leukocyte-platelet adhesion in whole blood." Blood 78, no. 7 (1991): 1730–37. http://dx.doi.org/10.1182/blood.v78.7.1730.1730.

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Abstract The dynamics of leukocyte-platelet adhesion and platelet-platelet interaction in whole blood are not well understood. Using different platelet agonists, we have studied the whole blood kinetics of these heterotypic and homotypic interactions, the relative abilities of different leukocyte subsets to participate in platelet adhesion, and the ligands responsible for adhesion. When platelet aggregation was inhibited by the Arg-Gly-Asp-Ser (RGDS) peptide, thrombin stimulation of whole blood resulted in platelet expression of granule membrane protein 140 (GMP-140) and, simultaneously, a mar
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Rinder, HM, JL Bonan, CS Rinder, KA Ault, and BR Smith. "Dynamics of leukocyte-platelet adhesion in whole blood." Blood 78, no. 7 (1991): 1730–37. http://dx.doi.org/10.1182/blood.v78.7.1730.bloodjournal7871730.

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The dynamics of leukocyte-platelet adhesion and platelet-platelet interaction in whole blood are not well understood. Using different platelet agonists, we have studied the whole blood kinetics of these heterotypic and homotypic interactions, the relative abilities of different leukocyte subsets to participate in platelet adhesion, and the ligands responsible for adhesion. When platelet aggregation was inhibited by the Arg-Gly-Asp-Ser (RGDS) peptide, thrombin stimulation of whole blood resulted in platelet expression of granule membrane protein 140 (GMP-140) and, simultaneously, a marked incre
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Bender, Markus, Anita Eckly, John H. Hartwig, et al. "ADF/n-cofilin–dependent actin turnover determines platelet formation and sizing." Blood 116, no. 10 (2010): 1767–75. http://dx.doi.org/10.1182/blood-2010-03-274340.

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Abstract The cellular and molecular mechanisms orchestrating the complex process by which bone marrow megakaryocytes form and release platelets remain poorly understood. Mature megakaryocytes generate long cytoplasmic extensions, proplatelets, which have the capacity to generate platelets. Although microtubules are the main structural component of proplatelets and microtubule sliding is known to drive proplatelet elongation, the role of actin dynamics in the process of platelet formation has remained elusive. Here, we tailored a mouse model lacking all ADF/n-cofilin–mediated actin dynamics in
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Wilkins, Ngozi A., Brian Storrie, and Jeffrey A. Kamykowski. "Characterization of Platelet Alpha-Granule Dynamics." Blood 116, no. 21 (2010): 327. http://dx.doi.org/10.1182/blood.v116.21.327.327.

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Abstract Abstract 327 Background: Platelets, anucleated cells that play a critical role in blood clotting, store proteins and small molecules in alpha-granules and dense granules, respectively, for secretion. Alpha-granules contain several proteins including von Willebrand factor and fibrinogen and dense granules contain serotonin. Rab4, a marker for the early endosomes has been implicated in regulating alpha granule secretions (Sirakawa et al, 2010). Previous fluorescence microscopy mapping of alpha-granule protein distributions suggested that there are either two different alpha-granule type
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Dubois, Christophe, Laurence Panicot-Dubois, Barbara C. Furie, and Bruce Furie. "Dynamics of Calcium Mobilization in Platelets during Thrombus Formation in a Living Mouse." Blood 106, no. 11 (2005): 649. http://dx.doi.org/10.1182/blood.v106.11.649.649.

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Abstract Platelet accumulation at sites of vascular injury arrests bleeding but also plays a critical role in the pathogenesis of thrombosis, leading to ischemia in myocardial infarction or stroke. Intracellular calcium mobilization in platelets is a critical step in the activation of platelets and formation of the platelet thrombus. Here we show the relationship of the dynamics of intracellular calcium mobilization with platelet accumulation into the developing thrombus in a living mouse. Following injection of 100 x 106 fura-2 loaded platelets into a living mouse we used high speed intravita
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Falet, Hervé, Gregory Chang, Brigitte Brohard-Bohn, Francine Rendu та John H. Hartwig. "Integrin αIIbβ3signals lead cofilin to accelerate platelet actin dynamics". American Journal of Physiology-Cell Physiology 289, № 4 (2005): C819—C825. http://dx.doi.org/10.1152/ajpcell.00587.2004.

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Cofilin, in its Ser3 dephosphorylated form, accelerates actin filament turnover in cells. We report here the role of cofilin in platelet actin assembly. Cofilin is primarily phosphorylated in the resting platelet as evidenced by a specific antibody directed against its Ser3 phosphorylated form. After stimulation with thrombin under nonstirring conditions, cofilin is reversibly dephosphorylated and transiently incorporates into the actin cytoskeleton. Its dephosphorylation is maximal 1–2 min after platelet stimulation, shortly after the peak of actin assembly occurs. Cofilin rephosphorylation b
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Patel, Dipti, Heikki Väänänen, Markéta Jiroušková, Thomas Hoffmann, Carol Bodian, and Barry S. Coller. "Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy." Blood 101, no. 3 (2003): 929–36. http://dx.doi.org/10.1182/blood.v101.3.929.

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Abstract The conventional description of platelet interactions with collagen-coated surfaces in vitro, based on serial static measurements, is that platelets first adhere and spread to form a monolayer and then recruit additional layers of platelets. To obtain dynamic information, we studied gravity-driven platelet deposition in vitro on purified type 1 collagen by video phase-contrast microscopy at 22°C. With untreated human and wild-type mouse platelets, soon after the initial adhesion of a small number of “vanguard” platelets, “follower” platelets attached to the spread-out vanguard platele
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Filipovic, N., M. Kojic, and A. Tsuda. "Modelling thrombosis using dissipative particle dynamics method." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 366, no. 1879 (2008): 3265–79. http://dx.doi.org/10.1098/rsta.2008.0097.

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Aim . Arterial occlusion is a leading cause of cardiovascular disease. The main mechanism causing vessel occlusion is thrombus formation, which may be initiated by the activation of platelets. The focus of this study is on the mechanical aspects of platelet-mediated thrombosis which includes the motion, collision, adhesion and aggregation of activated platelets in the blood. A review of the existing continuum-based models is given. A mechanical model of platelet accumulation onto the vessel wall is developed using the dissipative particle dynamics (DPD) method in which the blood (i.e. colloida
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Suzuki, Aae, Lurong Lian, Liang Zhao, et al. "Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia." Blood 116, no. 21 (2010): 549. http://dx.doi.org/10.1182/blood.v116.21.549.549.

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Abstract Abstract 549 In response to agonist stimulation, platelets undergo a rapid reorganization of their actin cytoskeleton. This process involves simultaneous disassembly and assembly of filamentous actin, and is one of the earliest phenomena seen in platelet activation. Ex vivo flow models suggest that the platelet cytoskeleton is required for platelet adhesion that can withstand the shear conditions found within the arterial vascular system. The signaling pathways that link external stimuli with actin assembly are believed to include polyphosphoinositides, small GTP-binding proteins, and
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Patel-Hett, Sunita, Jennifer L. Richardson, Harald Schulze, et al. "Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules." Blood 111, no. 9 (2008): 4605–16. http://dx.doi.org/10.1182/blood-2007-10-118844.

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Abstract The marginal band of microtubules maintains the discoid shape of resting blood platelets. Although studies of platelet microtubule coil structure conclude that it is composed of a single microtubule, no investigations of its dynamics exist. In contrast to previous studies, permeabilized platelets incubated with GTP-rhodamine-tubulin revealed tubulin incorporation at 7.9 (± 1.9) points throughout the coil, and anti-EB1 antibodies stained 8.7 (± 2.0) sites, indicative of multiple free microtubules. To pursue this result, we expressed the microtubule plus-end marker EB3-GFP in megakaryoc
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Dissertations / Theses on the topic "Platelet dynamics"

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Wong, Truman. "Dynamics of platelet shape change and aggregation size-dependent platelet subpopulations." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61778.

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Lane, I. F. "The relationship between platelet-vessel wall interaction thrombosis and atherosclerosis." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233551.

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Kasirer-Friede, Ana. "Dynamics of von Willebrand factor-mediated platelet aggregation in laminar flow : physical and molecular determinants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0020/NQ55344.pdf.

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Bark, David Lawrence Jr. "Mechanistic numerical study of trhombus growth." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22550.

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Sandmann, Rabea [Verfasser], Sarah [Akademischer Betreuer] Köster, and Florian [Akademischer Betreuer] Rehfeldt. "Blood Platelet Behavior on Structured Substrates : From Spreading Dynamics to Cell Morphology / Rabea Sandmann. Betreuer: Sarah Köster. Gutachter: Sarah Köster ; Florian Rehfeldt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1078420084/34.

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Andersen, Brandon Thomas. "Multi-Processor Computation of Thrombus Growth and Embolization in a Model of Blood-Biomaterial Interaction Based on Fluid Dynamics." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3465.

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This work describes the development and testing of a real-time three-dimensional computational fluid dynamics simulation of thrombosis and embolization to be used in the design of blood-contacting devices. Features of the model include the adhesion and aggregation of blood platelets on device material surfaces, shear and chemical activation of blood platelets, and embolization of platelet aggregates due to shear forces. As thrombus develops, blood is diverted from its regular flow field. If shear forces on a thrombus are sufficient to overcome the strength of adhesion, the thrombus is dislodge
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Fiusco, Francesco. "Hemodynamics of artificial devices used in extracorporeal life support." Licentiate thesis, KTH, Teknisk mekanik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-301039.

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Extracorporeal Membrane Oxygenation (ECMO) is a life-saving therapy usedfor support in critical heart and/or lung failure. Patient’s blood is pumped viaan artificial lung for oxygenation outside of the body. The circuit is composedof a blood pump, cannulae for drainage and reinfusion, a membrane lung,tubing and connectors. Its use is associated with thromboembolic complicationsand hemolytic damage. Detailed numerical studies of two blood pumps anda lighthouse tip drainage cannula were undertaken to characterize the flowstructures in different scenarios and their link to platelet activation. The p
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Hosseinzadegan, Hamid. "A Physio-chemical Predictive Model of Dynamic Thrombus Formation and Growth in Stenosed Vessels." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/89325.

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According to the World Health Organization (WHO), Cardiovascular Disease (CVD) is the leading cause of death in the world. Biomechanics and fluid dynamics of blood flow play an important role in CVD mediation. Shear stress plays a major role in platelet-substrate interactions and thrombus formation and growth in blood flow, where under both pathological and physiological conditions platelet adhesion and accumulation occur. In this study, a three-dimensional dynamic model of platelet-rich thrombus growth in stenosed vessels using computational fluid dynamics (CFD) methods is introduced. Platele
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Cosemans, Judith Maria Elisabeth Mathijs. "Dynamic regulation of thrombus stability focus on platelet receptors and downstream signaling /." Maastricht : Maastricht : Univeritaire Pers ; University Library, Universiteit Maastricht [host], 2009. http://arno.unimaas.nl/show.cgi?fid=14676.

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Naeem, Ali. "Optical properties and exciton dynamics of colloidal quantum dots, rods, and platelets." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/90269/.

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The linear optical properties and exciton dynamics of different semiconductor nanostructures have been studied. A model to describe the absoprtion spectra of cadmium selenide (CdSe) nanoplatelets (NPLs) has been developed, which allows the extraction of parameters relating to excitons confined within the thickness of the NPLs. Giant oscillator strength transitions (GOST) have been observed in NPLs with a lifetime limited dephasing of the ground state excitons at low temperature of about 1 ps, using transient resonant four wave mixing in heterodyne detection. The observation of the GOST effect
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Books on the topic "Platelet dynamics"

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Kuiper, Gerhardus J. A. J. M., and Hugo ten Cate. Coagulation monitoring. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0266.

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Haemostasis is a dynamic process to stop bleeding after vessel wall damage. Platelets form a platelet plug via activation, adherence, and aggregation processes. The coagulation proteins are activated one-by-one, cascading towards fibrin polymerization, a process controlled by thrombin generation. Fibrinolysis is the process responsible for fibrin mesh degradation, which is also controlled by thrombin. Besides procoagulant proteins, anticoagulant proteins maintain a balance in the haemostatic system. Measuring platelet count and function can be done as part of the monitoring of haemostasis, whi
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Albert, Tyler J., and Erik R. Swenson. The blood cells and blood count. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0265.

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Blood is a dynamic fluid consisting of cellular and plasma components undergoing constant regeneration and recycling. Like most physiological systems, the concentrations of these components are tightly regulated within narrow limits under normal conditions. In the critically-ill population, however, haematological abnormalities frequently occur and are largely due to non-haematological single- or multiple-organ pathology. Haematopoiesis originates from the pluripotent stem cell, which undergoes replication, proliferation, and differentiation, giving rise to cells of the erythroid, myeloid, and
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Lutgens, Esther, Marie-Luce Bochaton-Piallat, and Christian Weber. Atherosclerosis: cellular mechanisms. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0013.

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Atherosclerosis is a lipid-driven, chronic inflammatory disease of the large and middle-sized arteries that affects every human being and slowly progresses with age. The disease is characterized by the presence of atherosclerotic plaques consisting of lipids, (immune) cells, and debris that form in the arterial intima. Plaques develop at predisposed regions characterized by disturbed blood flow dynamics, such as curvatures and branch points. In the past decades, experimental and patient studies have revealed the role of the different cell-types of the innate and adaptive immune system, and of
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Book chapters on the topic "Platelet dynamics"

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Sakata, Asuka, and Satoshi Nishimura. "Bone Imaging: Platelet Formation Dynamics." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7762-8_3.

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Sheriff, Jawaad, and Danny Bluestein. "Platelet dynamics in blood flow." In Dynamics of Blood Cell Suspensions in Microflows. CRC Press, 2019. http://dx.doi.org/10.1201/b21806-7.

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Fogelson, Aaron, Haoyu Yu, and Andrew Kuharsky. "Computational Modeling of Blood Clotting: Coagulation and Three-dimensional Platelet Aggregation." In Polymer and Cell Dynamics. Birkhäuser Basel, 2003. http://dx.doi.org/10.1007/978-3-0348-8043-5_13.

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Qi, Qin M., and Eric S. G. Shaqfeh. "Microstructure and rheology of cellular blood flow, platelet margination and adhesion." In Dynamics of Blood Cell Suspensions in Microflows. CRC Press, 2019. http://dx.doi.org/10.1201/b21806-4.

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Nesbitt, Warwick S., Francisco J. Tovar-Lopez, Erik Westein, Ian S. Harper, and Shaun P. Jackson. "A Multimode-TIRFM and Microfluidic Technique to Examine Platelet Adhesion Dynamics." In Adhesion Protein Protocols. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-538-5_3.

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Nesbitt, Warwick S., Ian S. Harper, Simone M. Schoenwaelder, Yuping Yuan, and Shaun P. Jackson. "A Live Cell Micro-imaging Technique to Examine Platelet Calcium Signaling Dynamics Under Blood Flow." In Methods in Molecular Biology. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-307-3_6.

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Yablonka-Reuveni, Z., D. F. Bowen-Pope, and R. S. Hartley. "Proliferation and Differentiation of Myoblasts: The Role of Platelet-Derived Growth Factor and the Basement Membrane." In The Dynamic State of Muscle Fibers, edited by Dirk Pette. De Gruyter, 1990. http://dx.doi.org/10.1515/9783110884784-054.

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Felcher, G. P., and Y. Y. Huang. "Magnetism of thin film multilayers: an analogue of interacting platelets." In Structure and Dynamics of Strongly Interacting Colloids and Supramolecular Aggregates in Solution. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2540-6_34.

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Boudot, Cécile, Stefanie Recht, Markus Eblenkamp, Miriam Haerst, and Erich Wintermantel. "Protein Adsorption and Adhesion of Blood Platelets on Silicone Rubber under Static and Dynamic Flow Conditions." In IFMBE Proceedings. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11128-5_135.

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A. Matthay, Zachary, and Lucy Zumwinkle Kornblith. "Platelet Imaging." In Platelets. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.91736.

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The knowledge gained through imaging platelets has formed the backbone of our understanding of their biology in health and disease. Early investigators relied on conventional light microscopy with limited resolution and were primarily able to identify the presence and basic morphology of platelets. The advent of high resolution technologies, in particular, electron microscopy, accelerated our understanding of the dynamics of platelet ultrastructure dramatically. Further refinements and improvements in our ability to localize and reliably identify platelet structures have included the use of immune-labeling techniques, correlative-fluorescence light and electron microscopy, and super-resolution microscopies. More recently, the expanded development and application of intravital microscopy in animal models has enhanced our knowledge of platelet functions and thrombus formation in vivo, as these experimental systems most closely replicate native biological environments. Emerging improvements in our ability to characterize platelets at the ultrastructural and organelle levels include the use of platelet cryogenic electron tomography with quantitative, unbiased imaging analysis, and the ability to genetically label platelet features with electron dense markers for analysis by electron microscopy.
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Conference papers on the topic "Platelet dynamics"

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Bluestein, Danny, João S. Soares, Peng Zhang, et al. "Multiscale Modeling of Flow Induced Thrombogenicity Using Dissipative Particle Dynamics and Molecular Dynamics." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93094.

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The coagulation cascade of blood may be initiated by flow induced platelet activation, which prompts clot formation in prosthetic cardiovascular devices and arterial disease processes. While platelet activation may be induced by biochemical agonists, shear stresses arising from pathological flow patterns enhance the propensity of platelets to activate and initiate the intrinsic pathway of coagulation, leading to thrombosis. Upon activation platelets undergo complex biochemical and morphological changes: organelles are centralized, membrane glycoproteins undergo conformational changes, and adhe
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Bluestein, Danny, João S. Soares, Peng Zhang, et al. "Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics (DPD) and Molecular Dynamics (MD)." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16176.

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The coagulation cascade of blood may be initiated by flow induced platelet activation, which prompts clot formation in prosthetic cardiovascular devices and arterial disease processes. While platelet activation may be induced by biochemical agonists, shear stresses arising from pathological flow patterns enhance the propensity of platelets to activate and initiate the intrinsic pathway of coagulation, leading to thrombosis. Upon activation platelets undergo complex biochemical and morphological changes: organelles are centralized, membrane glycoproteins undergo conformational changes, and adhe
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Zhang, Peng, Jawaad Sheriff, João S. Soares, et al. "Multiscale Modeling of Flow Induced Thrombogenicity Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14187.

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The coagulation cascade of blood may be initiated by flow induced platelet activation, which prompts clot formation in prosthetic cardiovascular devices and arterial disease processes. While platelet activation may be induced by biochemical agonists, shear stresses arising from pathological flow patterns enhance the propensity of platelets to activate and initiate the intrinsic pathway of coagulation, leading to thrombosis. Upon activation platelets undergo complex biochemical and morphological changes: organelles are centralized, membrane glycoproteins undergo conformational changes, and adhe
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Mousel, J. A., H. S. Udaykumar, and K. B. Chandran. "Multiscale Modeling of Platelet Dynamics in Blood Flow With Application to Thrombus Formation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192780.

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From an averaged point of view, blood can often be treated computationally as a single-phase fluid of non-Newtonian character. Such a model may be appropriate if information regarding the bulk motion of the blood is all that is required. If, however, one seeks to describe the mechanisms leading to diseases such as thrombosis in the presence of foreign surfaces such as prosthesis, accurate predictions of platelet behavior in the dynamic environment of the blood are required. There are several effects that necessitate a careful treatment of platelet dynamics. For example, it is well known that t
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Badimon, J. J., L. Badimon, A. Galvez, J. Camunas, and V. Fuster. "DYNAMICS AND LOCALIZATION OF PLATELET DEPOSITION ON A SYNTHETIC VASCULAR GRAFT: CONTINUOUS IMAGING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643954.

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The in vivo dynamics of thrombus formation have not been extensively studied, mainly due to technical limitations. We assessed the dynamics and localization of platelet deposition on a prosthetic vascular graft for the first 24 hours after implantation in swine, with continuous monitoring during the initial 6 hours, and the effect of heparin. Polytetrafluoro-ethylene (PTFE) grafts (5cm. L × 0.5 cm. ID) were inplanted in one of the common carotids of 13 normal pigs; 8 received iv heparin (150uAg) perioperatively. 111 In-labelled autologous platelets were injected 5 min before reperfusion of the
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Hoore, Masoud, Dmitry A. Fedosov, and Gerhard Gompper. "Video: Mechanical Dissociation of Platelet Aggregates in Blood Stream." In 70th Annual Meeting of the APS Division of Fluid Dynamics. American Physical Society, 2017. http://dx.doi.org/10.1103/aps.dfd.2017.gfm.v0008.

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Longmire, K., and M. M. Frojmovic. "PLATELET AGGREGATION DYNAMICS TO ADENOSINE DIPHOSPHATE IN NON-STIRRED SUSPENSIONS: LONG-RANGEINTERACTIONS FOR HUMAN, BUT NOT RABBIT, PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644464.

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The simplest experimental approach for a theoretical description of platelet aggregation is based on kinetics of early multiplet formation (‹4 platelets per aggregate)occurring with diffusion-dependent particle collisions (no flow). The Smoluchowski theory was used to calculate collision efficiencies, αβ, from a linear plot of platelet particle count (Nt)−1 vs time (t) following addition of adenosine diphosphate (ADP) to citrated platelet-rich-plasma (PRP) for 7 human (H) and 2 rabbit (R) donors. A 0.1 ml sample of PRP was stirred with ADP for 0.5s, then immediately transferred to a 37°C bath
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AlMomani, T., H. S. Udaykumar, J. Marshall, and K. B. Chandran. "Dynamic Simulation of Red Blood Cells/Platelet Interaction in Arteriolar Blood Flow." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175290.

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Hemodynamic forces have been proposed as a major factor in thrombosis (thrombus formation) in the human cardiovascular system [1]. It has been suggested that platelet activation, aggregation and adhesion to the surface of the implants result in the formation of the mural thrombi [2]. Red blood cells (RBCs) are thought to play a significant role in the dynamics and the activation of the platelets and hence thrombus formation in the human arterial system. Previous experimental works indicate that RBCs cause platelets to migrate and move toward the vessel walls [3]. Thrombus formation has also be
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Palankar, R., M. Medvidov, J. Wesche та A. Greinacher. "Single-molecule Labeling and Tracking of FcγRIIA on Human Platelets Reveals Differential Mobility Dynamics, which Depends on Platelet Cytoskeletal Integrity". У 63rd Annual Meeting of the Society of Thrombosis and Haemostasis Research. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1680095.

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Palankar, R., M. Medvidov, J. Wesche та A. Greinacher. "Single-molecule Labeling and Tracking of FcγRIIA on Human Platelets Reveals Differential Mobility Dynamics, which Depends on Platelet Cytoskeletal Integrity". У 63rd Annual Meeting of the Society of Thrombosis and Haemostasis Research. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1680196.

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