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Dissertations / Theses on the topic 'Platelet function'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Hayman, Melissa Anne. "Genomic influences on platelet function." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/36221.

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The study of platelet messenger and micro-RNAs is of increasing interest owing to the fact that platelets contain the machinery to splice and translate mRNA into proteins in response to inhibitory or activating signals. However, the relatively small size (roughly 4000-5000 transcripts) and short half-life of the platelet transcriptome makes this a technically challenging aspect of platelet biology to investigate. The aims of these thesis investigations were therefore to optimise protocols for the isolation of platelets for downstream RNA analyses and function testing, to investigate the functi

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2

Arunima, Ghosh. "Role of CD36 in Platelet Function." Cleveland State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=csu1199991110.

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3

Vickers, James. "Endothelial cells and platelet function." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336951.

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4

Radhakrishnan, Aparna. "Genetic variation studies of megakaryopoiesis, platelet formation and platelet function." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708102.

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5

Cauwenberghs, Sandra. "Platelet responsiveness and function during storage implications for platelet transfusion therapy /." [Maastricht : Maastricht : Maastricht University] ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=12756.

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6

Davies, Anna. "Platelet function in the presence of Synthocytes : a novel platelet substitute." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324048.

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7

Smout, Jonathan Daniel. "Platelet function in atherosclerotic vascular disease." Thesis, University of Newcastle upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417517.

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8

Rolf, Michael George. "P2X₁ receptors and human platelet function." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621241.

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9

Peacock, Lesley. "Isomeric fatty acids and platelet function." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253708.

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1. <i>Cis</i> unsaturated fatty acids were shown to inhibit porcine platelet aggregation in response to both collagen and thrombin. Fatty acids with a <i>trans</i> double bond had an anti-aggregatory effect on collagen-induced aggregation but this was significantly less than that observed with the <i>cis</i> equivalent and was diminished as the dose of agonist increased. Thrombin-induced platelet aggregation was unchanged or slightly potentiated by <i>trans</i> isomers. 2. Both the <i>cis</i> and <i>trans</i> isomeric acids inhibited collagen-induced TXB<sub>2</sub> production. The <i>trans</i

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10

Tymkewycz, Paulina M. "Biologically active lipids and platelet function." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/30866.

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11

Gupta, Nilaksh. "UBIQUITIN-PROTEASOME SYSTEM MODULATES PLATELET FUNCTION." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1408896695.

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12

Burns, P. Y. "An investigation of the platelet transcriptome and its relationship to platelet function." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597130.

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The platelet is an anucleate cell fragment released into the blood from its progenitor cell the megakaryocyte (MK). It was the aim of this thesis to explore the relationship between platelet functional responses and variation in the platelet transcriptome. Rigorous quality assessment of platelet RNA was completed to determine its suitability for DNA microarray investigation. The transcriptomes of individuals homozygous for the major and minor haplotypes of the collagen receptor GPVI, which show differences in signalling responses, were compared using cDNA microarrays. Fifty-two differentially

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13

Stafford, Margaret Jackson. "Protein kinase C in platelet signalling." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275204.

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14

Manolopoulos, Panagiotis. "Effects of Antiplatelet Agents on Platelet Function." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519417.

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15

Savage, Joshua S. "Protein kinase-dependent regulation of platelet function." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559232.

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Platelets are essential in the initiation, growth and stabilisation of thrombi in normal haemostasis upon injury to the vasculature, or in cardiovascular disease upon rupture of an atherosclerotic plaque. Protein kinases are a crucial component in platelet signalling pathways, playing a combination of positive and negative regulatory roles. The AGC kinase family contains several known key regulatory kinases in platelet signalling, most notably PKC. PKC is largely considered a positive regulator of platelet function, although recent data suggests that some PKC isoforms play minor negative regul

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16

Li, Qi. "Platelet glycoprotein Ibα : structure, function, and immunogenicity". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627411.

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17

Banerjee, Sreemoti. "The role of glucocorticoids in platelet function." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10818.

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Platelets are pivotal in regulating haemostasis, but can precipitate atherothrombosis associated to cardiovascular diseases. The synthetic glucocorticoid prednisolone is widely used as an anti-inflammatory and immunosuppressive drug. Previously it was shown that prednisolone inhibited platelet aggregation and adhesion under conditions of flow, although the mechanisms remained unclear. In the present study we examined the mechanisms responsible for the inhibitory effects of prednisolone on thrombin‐mediated platelet activation. Prednisolone caused concentration‐dependent inhibition of thrombin‐

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18

Le, Blanc Katarina. "Platelet function in polycythemia vera : studies of agonist and cytokine induced platelet activation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3442-8/.

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19

Cleanthis, T. M. "Platelet function in lower limb peripheral arterial disease." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432504.

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20

Gorog, Diana Adrienne. "Influences on platelet function in coronary artery disease." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272333.

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21

Scott, Nigel T. "Investigations on human factor 8 and platelet function." Thesis, University of East London, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353257.

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22

Wake, Jonathan D. "Regulation of blood platelet function by nitric oxide." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:7085.

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Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug. This self-amplifying mechanism requires a tight control to prevent uncontrolled platelet aggregate formation that could occlude the vessel. Endothelial-derived nitric oxide (NO) and prostacyclin (PGI₂) are strong negative regulators that modulate platelet adhesion, activation, aggregation, secretion and shape change. In this study the effects of NO on Ca²+ dependent and independent pathways of activation were investigated. The data pr

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23

Wilkinson, Ashley R. "Platelet Function in Dogs with Chronic Liver Disease." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/89916.

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Platelet function in dogs with chronic liver disease Ashley R. Wilkinson Background: Dogs with acquired chronic liver disease often have hemostatic derangements. It is currently unknown whether dogs with acquired chronic liver disease have decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. Hypothesis: Dogs with chronic liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal bleeding time (BMBT), and increased vWF concentration compared to healthy dogs. An

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24

Forster, Trevor Henry. "Effect of inhibitors of platelet function in haemostasis." Thesis, Queensland University of Technology, 1986. https://eprints.qut.edu.au/36709/1/36709_Forster_1986.pdf.

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Investigation of the role of platelets in the haemostatic process has been a high priority for many years. In spite of this the mechanisms by which platelets help to maintain vascular integrity in undamaged blood vessels have not been clearly defined. The concept of endothelial support suggested by the work of Wojcik, Van Horn, Webber and Johnson (6) has been controversial as it implies a direct interaction between platelets and endothelium. An alternate theory offered has been that of platelet support by attachment to sub-endothelium following damage to the endothelial cell layer.

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25

VISCONTE, CATERINA. "Roles of Amyloid Precursor Protein in Platelet Function." Doctoral thesis, Università degli studi di Pavia, 2018. http://hdl.handle.net/11571/1220626.

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26

Hetherington, Simon Lee. "Sequence variation within the platelet adenosine diphosphate receptor genes, platelet function and premature myocardial infarction." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/27869.

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27

Jagroop-Dearing, I. A. "Effect of antithrombotic drugs on platelet function and receptors and an investigation into platelet cholesterol." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1338581/.

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The aim of this thesis was to assess several aspects of platelet function, especially in response to drugs. Peripheral arterial disease (PAD) is associated with hyperactive platelets that may be resistant to aspirin. Therefore, the effect of the administration of clopidogrel, aspirin or both anti-platelet agents was investigated in patients with PAD. Platelet function was assessed by different techniques including platelet shape change (PSC), an early phase of platelet activation that precedes aggregation. PSC was measured using a high-resolution channelyzer and expressed as median platelet vo

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28

McNicol, A. "Desensitisation and potentiation of platelet inositol phospholipid hydrolysis." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234872.

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29

Sofie, Sjöberg. "Evaluation of a standardized platelet concentration in samples from platelet concentrates measured over time with impedance aggregometry." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254606.

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Platelet transfusions can be necessary during treatment of patients with thrombocytopenia or impaired platelet function. Platelet function in platelet concentrates (PC) deteriorate with storage time. Studying swirling is often used to control the quality of PC’s before transfusion but the method has some disadvantages. Therefore other methods can be useful, for example impedance aggregometry (IA, Multiplate® Analyzer) to measure platelet function. In this study the change in platelet function over time was examined in buffy coat and apheresis platelets with IA where aggregation had been i

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30

Neuger, Jolanta. "Platelet serotonin function and personality traits in affective disorder /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-181-0.

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31

Jones, Sarah. "Peripheral tachykinins and the NK1 receptor regulate platelet function." Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493813.

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Tachykinins are a family of neuropeptides characterised by the conserved C-terminal motif FXGLM-NH2, where X represents a hydrophobic amino acid. Substance P (SP) a member of the tachykinin family has recently been shown to stimulate platelet aggregation and a SP-like immunoreactivity has been demonstrated in platelets and shown to be released upon platelet activation, suggesting that SP may act as a secondary platelet agonist. In recent years a gene encoding new members of the tachykinin family has been identified named TTAC4, which unlike the classical tachykinins is predominantly expressed

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32

Jeenapongsa, Rattima. "Ageing and platelet cell membrane and adenylate cyclase function." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312000.

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33

Betteridge, Denis John. "Platelet function in subjects with diabetes mellitus and hyperlipidaemia." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305159.

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Premature vascular disease is an important cause of morbidity and mortality in Western countries and two groups particularly at risk from premature and extensive vascular disease are diabetic and hyperlipidaemic patients. In addition diabetics develop a specific microvascular disease affecting the capillaries resulting in retinopathy, nephropathy and contributing to neuropathy. Many factors may be involved in the pathogenesis of vascular disease in these two patient groups. In this thesis particular attention has been given to the detection of enhanced platelet function as platelets are import

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34

Nkambule, Bongani Brian. "Investigating platelet function and immune activation in HIV-infection." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97022.

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Thesis (PhD)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Introduction In the era of antiretroviral therapy (ART), people living with Human Immunodeficiency Virus (HIV) now have prolonged life spans. An emerging trend of non- acquired immune deficiency syndrome (AIDS) related complications now prevails in the aging HIV infected population. Increased levels of inflammation and chronic immune activation are associated with HIV infection. In the era of ART people living with HIV are at an increased risk of cardiovascular disease (CVD). Platelets play a pivotal role in both inflammat

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35

Pickles, David M. "Effects of hyperbaric stresses on platelet function in vitro." Thesis, University of Aberdeen, 1988. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU020654.

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Platelets of divers undergo changes following exposure to high pressures and decompression. Since the latter is associated with formation of intravascular bubbles, platelet-rich plasma (PRP) was treated to reproducible doses of bubbles of air, with and without enrichment by 5% Co2 (to maintain physiological pH). PRP was also subjected to stirring and a 'rocking' procedure. Bubbles caused significant aggregation, measured turbidimetrically, of human (but not bovine) platelets, particularly without pH control, whereas little occurred with stirring and rocking. Bubbling inhibited subsequent ADP-i

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36

Albanyan, Abdul-Majeed. "Application of novel tests of platelet function and senescence to the study of the platelet storage lesion." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496819.

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37

Rumley, Ann. "Fibrinolytic and endothelial markers in cardiovascular disease and diabetes mellitus." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298976.

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38

Newton, Justin Philip. "Structure and function of CD31." Thesis, University of Oxford, 1997. https://ora.ox.ac.uk/objects/uuid:0183ecb4-a147-4772-a957-f53ae6ea367c.

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The regulated interaction of leukocyte with endothelium is of key importance during normal immune surveillance and leukocyte infiltration to sites of infection in the inflammatory response. This thesis is concerned with the structure and function of CD31 (platelet-endothelial cell adhesion molecule-1), one of the adhesion molecules implicated in these processes. Previous work has shown both in vivo and in vitro that CD31 is involved in the final step of leukocyte recruitment, transmigration across the endothelial monolayer. CD31 mediated adhesion is complex, since it is capable of mediating mu

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39

Dhanjal, Tarvinder Singh. "The role of PECAM-l in platelet function and formation." Thesis, University of Birmingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487509.

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PECAM-I is a 130kDa member ofthe immunoglobulin superfamily, expressed on the surface ofhaematopoietic cells. The cytoplasmic tail contains two immullOreceptor tyrosine based inhibition motifs which can mediate both stimulatory and inhibitory signals. The aim of this thesis is to investigate the function of PECAM-I in the regulation of platelet activation and fonnation. Using PECAM-Io/' mice and cross-linking of PECAM-I using specific antibodies, I demonstrate a minor inhibitory role on platelet responses to the collagen receptor GPVI, the integrin allb~3 and the C-type lectin receptor CLEC-2.

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40

Best, Denise. "Quantitative and qualitative aspects of glycoprotein VI in platelet function." Thesis, University of the West of England, Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409463.

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41

Graham, Gwenda Joanne. "The role of tachykinins in the regulation of platelet function." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408330.

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42

Qu, Jiamin. "Effects of platelet-derived growth factor on human neutrophil function." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385249.

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43

Navaratnam, K. "Platelet function and response to low-dose aspirin in pregnancy." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3009774/.

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Pre-eclampsia is a serious multisystem disorder unique to pregnant women and associated with significant maternal and perinatal morbidity and mortality worldwide. Despite the investment of decades of basic science and clinical research, the pathophysiology of pre-eclampsia has been incompletely illustrated. In low doses, the cyclooxygenase inhibitor and antiplatelet, aspirin, can redress the thromboxane/prostacyclin imbalance observed in pregnancies affected by pre-eclampsia. Low-dose aspirin is currently recommended for high risk pregnancies in many countries, despite affording only modest ov

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44

Apostoli, Georgina Lorraine. "Targeting the nitric oxide signalling pathway to modulate platelet function." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44082.

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Nitric oxide (NO) negatively regulates platelets and impaired NO signalling can lead to arterial thrombosis. The source of platelet-derived NO is unclear with recent proposals of NO synthase (NOS) independent NO sources, such as S-nitrosothiols (RSNOs) and inorganic nitrate/nitrite. Sildenafil citrate, a phosphodiesterase 5 (PDE5) inhibitor, enhances NO/cGMP signals in cells expressing PDE5 such as platelets. The aims of this study were to investigate the antiplatelet properties of sildenafil, its mechanism of action and to determine the upstream sources of NO affecting platelet function. The

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45

Bushfield, M. "Regulation of platelet function by cytosolic free calcium and cyclic AMP." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233164.

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46

Bachmair, Eva-Maria. "Modulation of human platelet function by conjugated linoleic acid from a proteomics and functional perspective." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201837.

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47

Jiang, Honghui. "Studying platelet and monocyte function in atherosclerosis by employing quantitative proteomics." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62897.

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Atherosclerosis is the major cause of cardiovascular diseases. Both monocytes and platelets are key players in the development and progression of atherosclerosis. Monocyte adhesion, transmigration, and differentiation contribute to atherosclerotic plaque formation. Activated platelets release their granule contents, platelet releasate, to activate and modulate monocytes. The platelet releasate consists of a large number of bioactive proteins, including multiple cytokines and chemokines. The binding of chemokines to specific G protein-coupled receptors in the plasma membrane of monocytes can in

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48

Dickinson, Karen Joanna. "The regulation of platelet function in patients with peripheral arterial disease." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598024.

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Platelets play an important role in the pathogenesis of atherothrombosis and, as such, measuring platelet dysfunction in patients with peripheral arterial disease (PAD) may be a useful prognostic marker for future cardiovascular events. Detecting increased platelet activity but also reduced platelet inhibition is important in the management of these patients. Prediction of cardiovascular risk could allow tailored anti-platelet regimens in high risk groups. Dissection of platelet function in patients with PAD could allow cardiovascular risk stratification and the aim of this thesis was to devel

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49

Wakeman, Lisa Jayne. "Whole blood platelet function testing as an adjunct to thrombophilia screening." Thesis, University of the West of England, Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601348.

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Platelet hyperaggregability, including Sticky Platelet Syndrome has been identified as a cause of thrombotic conditions including venous thrombosis and foetal loss. The laboratory diagnosis of classical Sticky Platelet Syndrome is based on enhanced platelet aggregation responses to submaximallevels of adenosine diphosphate and epinephrine by optical aggregometry techniques. This study sought to evaluate platelet hyperaggregability by Multiple Electrode Aggregometry, PFA-100 analysis and quantitative analysis of associated platelet parameters as an adjunct to thrombophilia screening. Forty nine

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50

Al, Ghaithi Rashid Hafidh Rashid. "Laboratory investigation of platelet function in patients with mild bleeding disorders." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8173/.

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Platelets play a crucial role in haemostasis by preventing bleeding at sites of vascular injury. Inherited or acquired platelet defects can impair haemostasis resulting in bleeding symptoms of varying severity ranging from mild to excessive which can be life threatening. Diagnosis of mild platelet-based bleeding disorders is challenging due to the absence of a gold standard technique and their variable bleeding symptoms and bleeding phenotypes observed in healthy individual as well as other haemostatic disorders. The work in this thesis built on the previous studies in the genotyping and plate

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