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Journal articles on the topic 'Platelet Rich Fibrin Matrix (PRFM)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kumar, Ajin S., Syam K. Venugopal, Laiju M, et al. "Preparation of canine platelet rich fibrin membrane and its characterisation using light microscopy and scanning electron microscopy." Journal of Veterinary and animal sciences 55, no. 4 (2024): 698–703. https://doi.org/10.51966/jvas.2024.55.4.698-703.

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The current study was undertaken to analyse the cellular components and three-dimensional organisation of “platelet rich fibrin” membrane (PRFM), an autologous blood derived biomaterial. Ten millilitres of whole blood collected from six canine patients which was then centrifuged at 542.4G (3200 rpm for 10 minutes). The PRF clot thus obtained was pressed to form the platelet rich fibrin membrane (PRFM). The structural analysis and cell composition of PRFM was analysed using scanning electron microscopy (SEM) and histopathology. Evaluation with SEM revealed clearly organised fibrin in parallel s

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Chittoria, Ravi Kumar. "Role of Platelet Rich Fibrin Matrix (PRFM) in Pressure Injury Management." Journal of Clinical Research and Reports 15, no. 5 (2024): 01–04. http://dx.doi.org/10.31579/2690-1919/363.

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Platelet-rich fibrin matrix, which is rich in growth factors, has been demonstrated to be beneficial in the treatment of non-healing ulcers in recent research. Aim of this study is to evaluate the role of Platelet Rich Fibrin Matrix (PRFM) in pressure injury management. In our study, after two session of Platelet Rich Fibrin Matrix (PRFM) application, the pressure sore was cover with granulation tissues.

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Rao, Ashwath, Manikanta K. S., and Mir Md Noorul Hassan. "Plasma or Fibrin Matrix? A Comparative Study between PRP versus PRFM Therapy in Diabetic Foot Ulcer." New Indian Journal of Surgery 14, no. 3 (2023): 9–14. http://dx.doi.org/10.21088/nijs.0976.4747.14323.1.

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Introduction: Diabetic foot ulcer is one of the most common conditions encountered in surgical OPD. The incidence of a diabetic foot ulcer is around 15% among the diabetic population. Around 80% of non-traumatic amputation is due to chronic diabetic foot ulcer. Recent advances are made in treating wounds in which platelet-rich plasma (PRP) and platelet rich fibrin matrix (PRFM) therapy have proven beneficial. Materials and Methods: A prospective study was conducted from February 2021 to February 2023, for a period of 2 years which included 42 patients. Group A received autologous platelet rich

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Agri, Hardianti, Gadis Sabrina Tobo, Abdul Qadar Punagi, Riskiana Djamin, Syahrijuita Syahrijuita, and Yarni Alimah. "Sebuah Review: Manfaat Platelet Rich Plasma, Platelet Rich Fibri, dan Platelet Rich Fibrin Matrix pada Kasus Rinologi." Jurnal Riset Multidisiplin Agrisosco 2, no. 3 (2024): 130–35. https://doi.org/10.61316/jrma.v2i3.99.

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Penggunaan PRP banyak dikombinasi dengan materialmaterial graft seperti graft autogenus, graft sintetic atau dapat dengan kombinasi sel stem mesenkim. Keuntungannya antara lain keamanan (karena merupakan bahan autologus), peningkatan pengendapan trombosit dan faktor pertumbuhan di area penyembuhan, dan waktu persiapan yang singkat. Struktur spesifik ini akan memainkan peran penting dalam meningkatkan migrasi sel, proliferasi sel, dan pembentukan siklik. Tinjauan ini menjelaskan bukti yang ada mengenai penggunaan plasma kaya trombosit dalam operasi THT. Hasil Kajian Pustaka menunjukkan Pengguna

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Sclafani, Anthony. "Platelet-Rich Fibrin Matrix (PRFM) for Androgenetic Alopecia." Facial Plastic Surgery 30, no. 02 (2014): 219–24. http://dx.doi.org/10.1055/s-0034-1371896.

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Simon, B. I., A. L. Zatcoff, J. J. W. Kong, and S. M. O’Connell. "Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane." Open Dentistry Journal 3, no. 1 (2009): 92–99. http://dx.doi.org/10.2174/1874210600903010092.

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Background: The healing potential of platelet growth factors has generated interest in using Platelet-Rich Plasma (PRP) in ridge preservation procedures. A canine study was performed to determine if extraction sites treated with platelet-rich fibrin matrix (PRFM) exhibit enhanced healing compared to sites treated with non-viable materials. Methods: Four dog’s extraction sockets were treated individually with PRFM, PRFM and membrane, Demineralized Freeze-Dried Bone Allograft (DFDBA) and membrane, PRFM and DFDBA, and untreated control. Treatment sequencing permitted clinical and histologic evalu

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Fu, Chun-Jiang, Jia-Bing Sun, Zheng-Gang Bi, Xu-Ming Wang, and Cheng-Lin Yang. "Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis." Clinical Rehabilitation 31, no. 2 (2016): 158–72. http://dx.doi.org/10.1177/0269215516634815.

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Objective: To perform a meta-analysis examining the effectiveness of platelet-rich plasma and platelet-rich fibrin matrix for improving healing of rotator cuff injuries. Data sources/design: A meta-analysis of eligible studies was performed after searching Medline, Cochrane, and EMBASE on 14 December 2015. Setting: University hospital. Participants: Patients with rotator cuff injuries. Review methods/intervention: Databases were searched using the keywords “PRP or platelet-rich plasma,” “PRFM or platelet-rich fibrin matrix,” “rotator cuff,” and “platelet-rich” for studies comparing outcomes of

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D, Darwin Britto, Rajesh Kesavan, Changam Sheela Sasikumar,, et al. "Autologous platelet-rich fibrin matrix in the treatment of diabetic foot ulcers: a case series." Global Wound Care Journal 1, no. 1 (2025): 36. https://doi.org/10.63896/gwcj.1.1.36.

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Diabetic foot ulcers remain a significant challenge in clinical practice, necessitating innovative strategies to improve healing outcomes. This case series investigates the clinical impact of autologous platelet-rich fibrin matrix (PRFM) in the treatment of non-healing diabetic foot ulcers. By meticulously examining five cases, the study reveals compelling outcomes, including substantial reductions in ulcer size and accelerated healing. Patient-specific considerations, along with a focus on adverse events, provide a comprehensive understanding of the impact of PRFM. The case series underscores

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Gole, Prachi V., Naziya Muhammed, and Siddhi R. Patadia. "Efficacy of autologous platelet rich fibrin matrix in the management of non-healing ulcers." International Journal of Research in Dermatology 5, no. 4 (2019): 686. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20194566.

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<p class="abstract"><strong>Background:</strong> Non healing ulcers have a worldwide prevalence of 1.9%-13.1% with lower extremity being the commonest site. They are difficult to manage for the physician and frustrating for the patient due longer duration of treatment, cost, unsatisfactory outcomes and impairment caused due to them. Standard conventional management may fail at times and hence growth factors derived from platelets have been tried in the management of these ulcers. The purpose of our study was to evaluate the efficacy of platelet rich fibrin matrix (PRFM) in tr

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Chiu, C.-H., P. Chen, W.-L. Yeh, et al. "The gelling effect of platelet-rich fibrin matrix when exposed to human tenocytes from the rotator cuff in small-diameter culture wells and the design of a co-culture device to overcome this phenomenon." Bone & Joint Research 8, no. 5 (2019): 216–23. http://dx.doi.org/10.1302/2046-3758.85.bjr-2018-0258.r1.

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Objectives Platelet-rich fibrin matrix (PRFM) has been proved to enhance tenocyte proliferation but has mixed results when used during rotator cuff repair. The optimal PRFM preparation protocol should be determined before clinical application. To screen the best PRFM to each individual’s tenocytes effectively, small-diameter culture wells should be used to increase variables. The gelling effect of PRFM will occur when small-diameter culture wells are used. A co-culture device should be designed to avoid this effect. Methods Tenocytes harvested during rotator cuff repair and blood from a health

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Hassan, Safiya, Prasad Dhadse, Pavan Bajaj, Kiran Sethiya, Chitrika Subhadarsanee, and Ranu Oza. "Comparative evaluation of platelet rich fibrin matrix (PRFM) membrane and platelet rich fibrin (PRF) membrane using the vestibular incision subperiosteal tunnel access (VISTA) approach technique for the treatment of multiple gingival recession in humans: A double-blind, parallel-group, randomized controlled clinical trial." F1000Research 12 (July 24, 2023): 872. http://dx.doi.org/10.12688/f1000research.133358.1.

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Background: In this evolutionary era of dentistry, newer techniques have evolved for complete coverage of multiple recession defects (MRDs). Since 2012, MRDs have been treated using the vestibular incision subperiosteal tunnel access (VISTA) approach and a variety of regenerating membranes with varying degrees of success. Platelet‑rich fibrin matrix (PRFM) membrane has shown a robust release of growth factors and was known to enhance the healing process. Thus, in this study we have evaluated the effectiveness of platelet-rich fibrin matrix (PRFM) with that of platelet-rich fibrin (PRF) membran

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Aizawa, Hachidai, Tetsuhiro Tsujino, Taisuke Watanabe, et al. "Quantitative Near-Infrared Imaging of Platelets in Platelet-Rich Fibrin (PRF) Matrices: Comparative Analysis of Bio-PRF, Leukocyte-Rich PRF, Advanced-PRF and Concentrated Growth Factors." International Journal of Molecular Sciences 21, no. 12 (2020): 4426. http://dx.doi.org/10.3390/ijms21124426.

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Platelet-rich fibrin (PRF) is a fibrin matrix enriched with platelets. The PRF matrix is thought to form a steep gradient of platelet density around the region corresponding to the buffy coat in anticoagulated blood samples. However, this phenomenon has not yet been proven. To visualize platelet distribution in PRF in a non-invasive manner, we utilized near-infrared (NIR) imaging technology. In this study, four types of PRF matrices, bio-PRF, advanced-PRF (A-PRF), leukocyte-rich PRF (L-PRF), and concentrated growth factors (CGF) were compared. Blood samples collected from healthy, non-smoking

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Salih, Rasim Mahdi, and Enas Fadhil Kadhim. "Histological Evaluation of Local Application of Peripheral Blood Mesenchymal Stem Cells and Platelet-Rich Fibrin Matrix on Bone Healing of Rats." Medical Journal of Babylon 22, no. 2 (2025): 393–99. https://doi.org/10.4103/mjbl.mjbl_669_23.

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Abstract Background: Bones are more than just the framework that binds the body together. Bones exist in diverse forms and sizes and serve a variety of functions. Repairing defects in bones remains a significant clinical medical problem. Bone is a highly vascularized tissue, meaning it relies on the close spatial and temporal interaction between blood vessels and bone cells to maintain skeletal integrity. Objective: The purpose of this research was to examine the effects of using platelet-rich fibrin matrix (PRFM) (supercell and glue) and peripheral blood stem cells to promote bone repair at t

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Andrei, Cătălin, Cristian Comănescu, Ion Pătraşcu, Viorel Perieanu, and Mădălina Perieanu. "Reducing edentulous ridge resorption by using PRF (Platelet Rich-Fibrin). Clinical case." Romanian Journal of Stomatology 62, no. 1 (2016): 5–9. http://dx.doi.org/10.37897/rjs.2016.1.1.

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Platelet rich-fibrin (PRF) is the ideal material for hard tissue augmentation after tooth extraction. It is based on patient’s fibrin and platelets and represents the main matrix of osteogenesis. The new A-PRF (Advanced-PRF) consists of monocytes that enrich the fibrin clot. These preparations certain growth factors and cytokines gradually released from the fibrin clot. This is the secret of osteogenesis process in PRF techniques of preserving the alveolar ridge.

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Comparing The Role of Mesenchymal Stem Cell Glue (MSCS) With Platelet Rich Fibrin (PRF) Gel in Treating Abrasions." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 5 (2024): 94–102. https://doi.org/10.5281/zenodo.15436856.

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<strong>Abstract</strong> <strong>Introduction: </strong>Abrasions are minor injuries to the body's skin and inner linings that can be seen on any part of the body, but are most commonly found on the forehead, nose tip, cheek, and chin region. Though, facial abrasions are superficial injuries, but it can also lead to unacceptable scars and appearances.  Hence, using the autologous medium as a dressing material over these abrasions can substantially reduce the tendency of scar and hyperpigmentation. A blood clot serves as the focal point for healing, with 95% red blood cells and 5% platele

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Belludi, Sphoorthi Anup, Sharaz Shaik, Neha Pradhan, and Sreeparvathy Rema. "Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report." Journal of Advanced Periodontology & Implant Dentistry 17, no. 1 (2025): 54–58. https://doi.org/10.34172/japid.025.3502.

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In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, an

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Goldfarb, Richard M., and Aaron L. Shapiro. "Benefits of Autologous Fat Grafting Using Fat Mixed with Platelet-Rich Fibrin Matrix (PRFM) Selphyl." American Journal of Cosmetic Surgery 29, no. 1 (2012): 62–64. http://dx.doi.org/10.5992/ajcs-d-11-00037.1.

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Simões-Pedro, Mara, Pedro Maria B. P. S. Tróia, Nuno Bernardo Malta dos Santos, António M. G. Completo, Rogerio Moraes Castilho, and Gustavo Vicentis de Oliveira Fernandes. "Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation." Polymers 14, no. 7 (2022): 1392. http://dx.doi.org/10.3390/polym14071392.

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Predictable outcomes intended by the application of PRF (platelet-rich fibrin) derivative membranes have created a lack of consideration for their consistency and functional integrity. This study aimed to compare the mechanical properties through tensile strength and analyze the structural organization among the membranes produced by L-PRF (leukocyte platelet-rich fibrin), A-PRF (advanced platelet-rich fibrin), and A-PRF+ (advanced platelet-rich fibrin plus) (original protocols) that varied in centrifugation speed and time. L-PRF (n = 12), A-PRF (n = 19), and A-PRF+ (n = 13) membranes were sub

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Sağsöz, Aslı, and Filiz Acun Kaya. "Use of platelet-rich fibrin (PRF) in the periodontology: A Review." Journal of Medical and Dental Investigations 4 (June 1, 2023): e230317. http://dx.doi.org/10.5577/jomdi.e230317.

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Platelets play an essential role in wound healing and periodontal regeneration, so using platelet concentrates can speed up wound healing after periodontal treatment. Platelet-rich fibrin (PRF), an autogenous concentrated blood product, is a fibrin matrix comprising molecular and cellular elements that allow for optimum improvement and PRF also increases the production of osteoprotegerin, which causes osteoblast proliferation and acts as an osteoconductive and osteoinductive material, initiating bone regeneration. Platelet-rich plasma (PRP) and PRF are platelet concentrates prepared from the p

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Iacono, Venanzio, Luca Padovani, Fjorela Qordja, et al. "Surgical and Biological Treatment with a Platelet-Rich Fibrin Matrix for Patellar Tendinopathy: Clinical Outcomes and Return to Sport at 2-Year Follow-Up." Journal of Personalized Medicine 14, no. 6 (2024): 567. http://dx.doi.org/10.3390/jpm14060567.

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Background: Patellar tendinopathy (PT) involves anterior knee pain and functional. Platelet-rich fibrin matrix (PRFM) is a promising biological therapy for tendinopathies. We examined a cohort of PT patients treated with tendon debridement and autologous PRFM at the 24-month follow-up to assess whether the combined treatment facilitated return to sports and yielded satisfactory clinical and functional scores. Methods: Baseline and 24-month visual analogue scale (VAS), Victorian Institute of Sport Assessment Scale for Patellar Tendinopathy (VISA-P), Tegner Activity Scale (TAS), and Blazina scor

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Rathod, Aishwarya, Priyanka Jaiswal, and Deepika Masurkar. "Advanced platelet rich fibrin in periodontal regeneration." AIMS Bioengineering 10, no. 2 (2023): 175–82. http://dx.doi.org/10.3934/bioeng.2023012.

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<abstract> <p>Regenerating periodontal tissue is the main goal of periodontal therapy. Periodontal tissue regeneration involves the development of new bone, cement, and periodontal ligaments on damaged tooth root surfaces in order to restore anatomy and function. In order to further enhance PRF (Platelet rich fibrin) and develop advanced platelet-rich fibrin, a slower rotating speed is proposed (A-PRFs). Cell dispersion is affected by centrifugation rate. The majority of the leukocytes in the PRF are concentrated near the bottom of the tube due to centrifugation rate. By switching

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Iacono, Venanzio, Simone Natali, Luca De Berardinis, Daniele Screpis, Antonio Pompilio Gigante, and Claudio Zorzi. "Return to Sports and Functional Outcomes after Autologous Platelet-Rich Fibrin Matrix (PRFM) and Debridement in Midportion Achilles Tendinopathy: A Case Series with 24-Month Follow-Up." Journal of Clinical Medicine 12, no. 7 (2023): 2747. http://dx.doi.org/10.3390/jcm12072747.

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(1) Background: Achilles tendinopathy (AT) is characterized by load-induced tendon pain, stiffness, and functional impairment that may affect the tendon midportion or insertion. Platelet-rich fibrin matrix (PRFM) is a promising adjunctive therapy for AT. We analyzed 24-month pain and functional outcomes in a cohort of patients managed by tendon debridement and autologous PRFM application to determine whether the combined treatment ensured an early return to sports/work and satisfactory clinical outcomes and functional scores. (2) Methods: The 24-month outcomes of 32 sport-practicing patients w

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Goswami, Poulami, Vivek Chaudhary, Ashtha Arya, Richa Verma, Gopikrishnan Vijayakumar, and Mallanna Bhavani. "Platelet-Rich Fibrin (PRF) and its Application in Dentistry: A Literature Review." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S5—S7. http://dx.doi.org/10.4103/jpbs.jpbs_435_23.

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ABSTRACT Platelet-rich fibrin (PRF) is a biocompatible fibrin matrix that acts as a resorbable membrane, collecting platelet cytokines, growth factors, and cells and releasing them. It is easily extracted from blood. Many dentists use PRF, a concentrated growth factor solution, to treat various lesions and regenerate tooth and oral tissues. This research examines the pros, cons, and suggestions of using PRF in dentistry.

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Vasudev, Diwakar, Dhananjay Vasudeva, Akanksha Garg, and Manisha Rani. "Platelet rich fibrin (PRF) and its application in oral surgery: A literature review." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 9, no. 1 (2023): 14–17. http://dx.doi.org/10.18231/j.jooo.2023.004.

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Platelet rich fibrin (PRF) is a autogenous platelet concentrate containing growth factors and cytokines, trapped in fibrin matrix. Growth factors which are present provides ideal environment for wound healing and regeneration of the tissues. Platelet Concentrate have evolved a long way since 1954. In recent time it has been used in the field of medical science including dentistry, oral surgery, plastic surgery, orthopaedic surgery etc. This review discuss the evolution of platelet concentrate, its preparation technique and its application in the field of dentistry and oral surgery.

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Pawan, Kumar, and Shivani. "Autologous Platelet Rich Fibrin Matrix versus Zinc Oxide and Phenytoin Paste in Non-Healing Ulcers: A Comparative Assessment." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 573–79. https://doi.org/10.5281/zenodo.13306784.

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<strong>Aim: </strong>The aim of the present study was to compare the therapeutic efficacy of autologous PRFM versus triple combination paste (zinc oxide, phenytoin, and mupirocin ointment) in non-healing ulcers. <strong>Methods: </strong>The present clinical trial was conducted in the Department of Dermatology, Patna Medical College and Hospital, Patna, Bihar, India for one year.  A total of 20 patients were included in the study with the age range 20–70 years. Patients with non-healing ulcers were selected from the outpatient department of Skin and VD. <strong>

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Vinayaka, Ambujakshi Manjunatha. "Advancements and clinical applications of extended platelet-rich fibrin (E-PRF)." Journal of Orofacial and Health Sciences 11, no. 4 (2024): 162–64. http://dx.doi.org/10.18231/j.johs.2024.032.

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Extended platelet-rich fibrin (E-PRF) has emerged as a potent biological agent in regenerative medicine and dentistry. It leverages the natural healing capacities of growth factors and cytokines from platelets and leukocytes to promote tissue repair. This systematic review explores the role of E-PRF in various clinical applications, including wound healing, bone regeneration, and periodontal therapy. The findings indicate that E-PRF provides an enhanced bioactive matrix, supporting superior clinical outcomes compared to conventional treatments. Future studies should focus on optimizing E-PRF p

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Anil, Kumar Yadav, Kumar Yadav Birendra, Kumar Gupta Vikas, and Pandey Rajesh. "Clinical Comparison of Extraction Socket Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) Employing Demineralized Freeze Dried Bone Material and Membrane." International Journal of Pharmaceutical and Clinical Research 14, no. 8 (2022): 727–32. https://doi.org/10.5281/zenodo.13361669.

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<strong>Background: </strong>Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a restorable membrane. <strong>Objectives:</strong> To evaluate healing of the facial bone defect with both these among two groups using DFDB and the outcome. <strong>Methods:</strong> The present study was undertaken in the Department of Oral & Maxillofacial Surgery, Career Dental College & Hospital, Lucknow to compare.  A total of 40 patients with maxil

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Rajeev, Kumar, Astik S.K., Bhaskar Subham, and Kumar Narendra. "A Hospital-Based Study to Assess the Role of Serum Vitamin D Levels in Severity of Dengue Fever - A Cross Sectional Study." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 581–85. https://doi.org/10.5281/zenodo.13306860.

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<strong>Aim: </strong>The aim of the present study was to compare the therapeutic efficacy of autologous PRFM versus triple combination paste (zinc oxide, phenytoin, and mupirocin ointment) in non-healing ulcers. <strong>Methods: </strong>The present clinical trial was conducted in the Department of Dermatology, Patna Medical College and Hospital, Patna, Bihar, India for one year.  A total of 20 patients were included in the study with the age range 20–70 years. Patients with non-healing ulcers were selected from the outpatient department of Skin and VD. <strong>

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Pratap, Chandra Das, Kumar Das Aswini, and Kashyap Pallavi. "Assessment of the Therapeutic Efficacy of Autologous PRFM versus Triple Combination Paste in Non-Healing Ulcers." International Journal of Toxicological and Pharmacological Research 13, no. 11 (2023): 249–53. https://doi.org/10.5281/zenodo.11003362.

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<strong>Aim: </strong>The aim of the present study was to compare the therapeutic efficacy of autologous PRFM versus triple combination paste (zinc oxide, phenytoin, and mupirocin ointment) in non-healing ulcers. <strong>Methods: </strong>The present clinical trial was conducted in the Department of Skin and V.D for two years. A total of 50 patients were included in the study with the age range 20–70 years. Patients with non-healing ulcers were selected from the outpatient department. <strong>Results: </strong>A total of 50 cases of non-healing ulcers of varying

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Subhadarsanee, Dr Chitrika, Dr Prasad Dhadse, Dr Pavan Bajaj, et al. "Comparative evaluation of platelet rich fibrin matrix (PRFM) membrane and collagen membrane with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular class II furcation defects: A randomized controlled trial." F1000Research 12 (October 20, 2023): 1387. http://dx.doi.org/10.12688/f1000research.131974.1.

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Aim- The aim of the study was to compare the effectiveness of platelet rich fibrin matrix (PRFM) membrane with collagen membrane (Colo Gide) in combination with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular Class II furcation defects. Methods- This randomized, parallel designed, controlled, clinical investigation was conducted in 24 subjects (15 male and 9 female) having Class II furcation defects either buccally or lingually. The test group was treated with DFDBA and PRFM membrane while the control group was treated with DFDBA and collagen membrane. The clin

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Kargarpour, Zahra, Jila Nasirzade, Layla Panahipour, Richard J. Miron та Reinhard Gruber. "Relative Centrifugal Force (RCF; G-Force) Affects the Distribution of TGF-β in PRF Membranes Produced Using Horizontal Centrifugation". International Journal of Molecular Sciences 21, № 20 (2020): 7629. http://dx.doi.org/10.3390/ijms21207629.

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Solid platelet-rich fibrin (PRF) is produced with centrifugation tubes designed to accelerate clotting. Thus, activated platelets may accumulate within the fibrin-rich extracellular matrix even before centrifugation is initiated. It can thus be assumed that platelets and their growth factors such as transforming growth factor-β (TGF-β) are trapped within PRF independent of their relative centrifugal force (RCF), the gravitation or g-force. To test this assumption, we prepared PRF membranes with tubes where clotting is activated by a silicone-coated interior. Tubes underwent 210 g, 650 g and 15

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Gowdar, Inderjit Murugendrappa, Mukesh Soni, Ipseeta Menon, et al. "Evaluation of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration." Journal of Pharmacy and Bioallied Sciences 17, Suppl 2 (2025): S1214—S1216. https://doi.org/10.4103/jpbs.jpbs_1652_24.

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ABSTRACT Background: Restoring the structure and functionality of the periodontal tissues that have been destroyed as a result of illness is the goal of periodontal regeneration. Because it contains growth factors and cytokines, platelet-rich fibrin (PRF) has become a potential regenerative biomaterial that may improve tissue regeneration and repair. Materials and Procedures: Forty individuals with a diagnosis of chronic periodontitis who were recommended for periodontal regeneration treatment participated in this research. Two groups of patients were randomly assigned: Group A (n = 20) had st

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Birendra, Prasad. "Assessing Efficacy of Autologous Platelet Rich Fibrin Matrix versus Zinc Oxide and Phenytoin Paste in Non-Healing Ulcers: A Comparative Study." International Journal of Current Pharmaceutical Review and Research 15, no. 08 (2023): 315–19. https://doi.org/10.5281/zenodo.12550680.

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AbstractAim: The aim of the present study was to compare the therapeutic efficacy of autologous PRFM versus triplecombination paste (zinc oxide, phenytoin, and mupirocin ointment) in non-healing ulcers.Methods: The present clinical trial was conducted in the Department of Skin and VD, for December 2019 toNovember 2020. A total of 60 patients were included in the study with the age range 20–70 years. Patients withnon-healing ulcers were selected from the outpatient department.Results: A total of 60 cases of non-healing ulcers of varying etiologies were treated using autologous plateletric

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Andrei, Cătălin, Cristian Comănescu, Ion Pătraşcu, Viorel Perieanu, and Mădălina Perieanu. "Positives effects of using PRF (Platelet Rich-Fibrin) in dental surgery. Clinical case." Romanian Journal of Stomatology 62, no. 1 (2016): 10–14. http://dx.doi.org/10.37897/rjs.2016.1.2.

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Inserting dental implants in proper prosthetic shaft is no longer an issue for dental surgeon due to development of biomaterials, especially bone substituent and bone regeneration techniques. However physiological healing processes of the human body guided researchers to obtain more predictable results. Therefore, they included more grown factors in augmentation materials reducing complications after surgery and during healing period. For this purpose, platelet concentrates were used in different shapes. The advantages of using PRF (Platelet Rich- Fibrin) in bone regeneration techniques consis

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Valenzuela-Mencia, Javier, and Francisco Javier Manzano-Moreno. "Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review." Biomimetics 10, no. 3 (2025): 172. https://doi.org/10.3390/biomimetics10030172.

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Platelet-rich fibrin (PRF) membranes are a biomaterial derived from the patient’s own blood, used in different medical and dental areas for their ability to promote healing, tissue regeneration, and reduce inflammation. They are obtained by centrifuging the blood, which separates the components and concentrates the platelets and growth factors in a fibrin matrix. This material is then moulded into a membrane that can be applied directly to tissues. The use of these PRF membranes is often associated with the use of different biomimetic materials such as deproteinized bovine bone mineral (DBBM),

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Alrayyes, Yasser, Saleh Aloraini, Ahmed Alkhalaf, and Reham Aljasser. "Soft-Tissue Healing Assessment after Extraction and Socket Preservation Using Platelet-Rich Fibrin (PRF) in Smokers: A Single-Blinded, Randomized, Controlled Clinical Trial." Diagnostics 12, no. 10 (2022): 2403. http://dx.doi.org/10.3390/diagnostics12102403.

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Background: Wound healing is essential in any surgical procedure, and multiple factors, such as smoking, can impair it. The aim of this clinical trial was to evaluate the ability of platelet-rich fibrin to enhance socket wound healing in smokers. Methods: A total of 18 smoker participants with forty non-restorable upper molars indicated for extraction were recruited to the study and were randomly allocated to four different groups for the assessment of four techniques: advanced platelet-rich fibrin (A-PRF), factor-enriched bone graft matrix with advanced platelet-rich fibrin (A/S-PRF), freeze-

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Ucer, Cemal, and Rabia S. Khan. "Alveolar Ridge Preservation with Autologous Platelet-Rich Fibrin (PRF): Case Reports and the Rationale." Dentistry Journal 11, no. 10 (2023): 244. http://dx.doi.org/10.3390/dj11100244.

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In dental implantology, alveolar ridge preservation (ARP) has emerged as a standard technique to address dimensional changes that affect alveolar ridge morphology following tooth loss. Various alternative graft materials, including xenografts, alloplasts, and allografts, have been effectively employed in fresh extraction sites for ARP. Current evidence suggests that these materials primarily serve as bio-scaffolds, which are slowly incorporated, thus necessitating a waiting period of at least 4–6 months before implant placement. Consequently, the ARP technique extends the overall duration of i

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Callanan, Tucker C., Antonio T. Brecevich, Craig D. Steiner, et al. "Single-center, consecutive series study of the use of a novel platelet-rich fibrin matrix (PRFM) and beta-tricalcium phosphate in posterolateral lumbar fusion." European Spine Journal 28, no. 4 (2018): 719–26. http://dx.doi.org/10.1007/s00586-018-5832-5.

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Panahipour, Layla, Rebecca Croci, Sara Guarnieri, and Reinhard Gruber. "PRF Lysates Enhance the Proliferation and Migration of Oral Squamous Carcinoma Cell Lines." Dentistry Journal 11, no. 10 (2023): 242. http://dx.doi.org/10.3390/dj11100242.

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Platelet-rich fibrin (PRF) is an autologous fibrin-rich matrix where activated platelets and leucocytes accumulate. PRF has a wide spectrum of clinical indications with the overall aim of supporting tissue regeneration which in dentistry includes the healing of healthy oral mucosa with epithelial cells. In oral squamous cell carcinoma lesions, however, epithelial cells undergo malignant transformation, indicated by their unrestricted proliferation and migration potential, which should not be further enhanced by a wound-healing formula. Yet, little is known about how oral squamous cell carcinom

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Purohit, Janhavi N., and Maya Sanjiv Indurkar. "Titanium platelet–rich fibrin (T-PRF) as doxycycline delivery system: an in-vitro study." International Journal of Oral Health Dentistry 10, no. 2 (2024): 91–94. http://dx.doi.org/10.18231/j.ijohd.2024.019.

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: Locally delivered anti-infective agents are one of the frequently used treatment strategies for the treatment of periodontal disease. Doxycycline (Doxy) is frequently preferred in periodontal therapy. Various carrier systems are available like Collagen sponges, mucoadhesive polymers. The use of PRF is a good strategy for drug delivery systems with its 3D matrix structure as a scaffold, as it can naturally degrade within a certain period of time without causing any allergic/inflammatory conditions in the body. Titanium platelet–rich fibrin (T-PRF) has a denser fibrin structure than PRF with l

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Maso, Adelaide. "AGING MANAGEMENT WITH THE USE OF EXOSOMES, PRP/PRF WITH ALBUMIN GEL (PLASMA GEL) AND ASSOCIATED TECHNIQUES IN OROFACIAL HARMONIZATION TREATMENT." Health and Society 4, no. 03 (2024): 200–215. http://dx.doi.org/10.51249/hs.v4i03.2107.

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Aging, it is a physiological process that involves a progressive decline in the function of the organs, with loss of homeostasis and increased likelihood of disease disease and death. This account focuses on the classic perspectives on the biogenesis of exosomes, and age-related associated changes. Due to its ability to transmit biological information between cells, this work also discusses the interaction of mesenchymal cell exosomes, as a potent adjuvant in the treatment of association of orofacial harmonization techniques. The demand for aesthetic and rejuvenating treatments is increasing i

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Vhanmane, Priyanka, Vidya Dodwad, Jeeth P. Rai, Sandipan Sarkar, Pranav Bharat Heshi, and Mrunmayee Atkare. "Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling." Journal of Pharmacy and Bioallied Sciences 17, Suppl 2 (2025): S1073—S1075. https://doi.org/10.4103/jpbs.jpbs_290_25.

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ABSTRACT Regenerative dentistry has seen significant advancements with the integration of innovative biotechnological approaches aimed at enhancing tissue repair and regeneration. Injectable platelet-rich fibrin (i-PRF) and micro-needling are two emerging techniques with synergistic potential for promoting tissue healing and regeneration. i-PRF, a second-generation platelet concentrate, is rich in growth factors and cytokines that facilitate cellular proliferation, angiogenesis, and extracellular matrix remodeling. Micro-needling, on the other hand, induces controlled micro-injuries to the tis

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Erdur, Emire Aybuke, Kuter Karakaslı, Elif Oncu, Bahadır Ozturk, and Sema Hakkı. "Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement:." Angle Orthodontist 91, no. 3 (2021): 285–92. http://dx.doi.org/10.2319/060320-508.1.

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ABSTRACT Objectives To evaluate the efficiency of injectable platelet-rich fibrin (i-PRF) in accelerating canine tooth movement and to examine levels of the matrix metalloproteinase-8 (MMP-8), interleukin-1β (IL-1β), receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand (RANKL), and osteoprotegerin (OPG) in the gingival crevicular fluid during orthodontic treatment. Materials and Methods Twenty patients (mean age = 21.4 ± 2.9 years) with Class II Division 1 malocclusion were included in a split-mouth study. The treatment plan for all patients was extractio

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Widyatmika, Putu Ardhy Parama, Muhammad Sjaifuddin Noer, and Magda Rosalina Hutagalung. "Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously." Folia Medica Indonesiana 58, no. 4 (2022): 305–12. http://dx.doi.org/10.20473/fmi.v58i4.16499.

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Highlights: This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage. The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed. BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material. Abstract: The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encou

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Zrnc, Tomislav A., Philipp Metzler, Wolfgang Zemann, and Shahram Ghanaati. "PRF in der Zahnmedizin." SWISS DENTAL JOURNAL SSO – Science and Clinical Topics 128, no. 9 (2018): 712–13. http://dx.doi.org/10.61872/sdj-2018-09-04.

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Platelet-rich-Fibrin (PRF) bezieht sich auf einen Bestandteil des natürlichen Blutes. Die sogenannte Fibrinmatrix ist angereichert mit Blutplättchen (Thrombozyten). Die Herstellung ermöglicht den Gewinn von PRF in Form einer Matrix oder eines Gels aus dem eigenen Blut und anschliessend die Applikation an entsprechend gewünschter Region. Die Vereinfachung der Materialgewinnung sowie das Fehlen biochemischer Aufbereitungsprozesse des Vollblutes unterscheiden die zweite Generation der Thrombozytenkonzentrate wesentlich vom PRP. PRF scheint die Regeneration von Knochen- und Weichgewebe, insbesonde

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Apaza Alccayhuaman, Karol Ali, Patrick Heimel, Stefan Tangl, et al. "Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model." Bioengineering 11, no. 5 (2024): 414. http://dx.doi.org/10.3390/bioengineering11050414.

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Platelet-rich fibrin, the coagulated plasma fraction of blood, is commonly used to support natural healing in clinical applications. The rat calvaria defect is a standardized model to study bone regeneration. It remains, however, unclear if the rat calvaria defect is appropriate to investigate the impact of human PRF (Platelet-Rich Fibrin) on bone regeneration. To this end, we soaked Bio-Gide® collagen membranes in human or rat liquid concentrated PRF before placing them onto 5 mm calvarial defects in Sprague Dawley rats. Three weeks later, histology and micro-computed tomography (μCT) were pe

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Soliman, Ahmed. "Assessment of the Effectiveness of Revascularization Methods Utilizing Platelet-Rich Fibrin (PRF) Concentrate Versus Clot formation as a Supportive Matrix." Egyptian Dental Journal 70, no. 2 (2024): 2041–45. http://dx.doi.org/10.21608/edj.2024.264047.2889.

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Vilhena de Carvalho Fürst, Rafael, Roberto Lichtztejn Fech, Felipe Jiung Jun Lee, Ruben Zuniga, and João Antonio Corrêa. "Use of autologous tissue regeneration matrix (pro prf) in the treatment of diabetic ulcers: case series." Journal of Human Growth and Development 34, no. 3 (2024): 482–91. https://doi.org/10.36311/jhgd.v34.16849.

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Introduction: diabetes mellitus significantly contributes to chronic ulcers, with over 30% of diabetics over 40 affected by lower limb ulcers, which can lead to severe complications if untreated. The Progressive Platelet Rich Fibrin (PRO-PRF) tissue regeneration matrix can be a technique to improve the dimensions of the membrane, its strength and cell distribution, aiding in the treatment of tissue reconstruction. Objective: to describe a series of cases of diabetic ulcers treated with autologous tissue regeneration matrix (PRO-PRF). Methods: a prospective, interventional case series study usi

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Tissiani, Márcio Guilherme, Adriana Vanderlei Do Amorim, Alisson Aiac Amorim, Thimóteo De Almeida Barbosa, and Maylon Luciano Garcia Barbosa. "LEVANTAMENTO DE SEIO MAXILAR POTENCIALIZADO COM PRF." Revista ft 29, no. 141 (2024): 32–33. https://doi.org/10.69849/revistaft/fa10202413122232.

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Introduction: The knowledge of the anatomy of the maxillary sinus is the first step to implement the technique, Platelet-Rich Fibrin (PRF) is a matrix that enhances bone regeneration (CHOUKROUN, 2006) which occurs by increasing the concentration of growth factors. Objective: to analyze the use of PRF as a resource that enhances the procedure for lifting the maxillary sinus. Methodology: integrative literature review conducted through a search in scientific databases PubMed, LILACs, Academic Google and Scielo, having as inclusion criteria studies published between the years 2015 to 2020 and for

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Kachhawa, Dilip, Shreyansh Bhansali, and Pankaj Rao. "To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer." Journal of Cutaneous and Aesthetic Surgery 15, no. 1 (2022): 17. http://dx.doi.org/10.4103/jcas.jcas_196_20.

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