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Journal articles on the topic 'Platelet Rich Fibrin (PRF)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Malgikar, Suryakanth, and Vidya Sagar Sisinty. "Comparative Evaluation of Titanium-platelet-rich Fibrin and Leukocyte-platelet-rich Fibrin – A Scanning Electron Microscopic Study." Journal of Interdisciplinary Dentistry 13, no. 3 (2023): 134–37. http://dx.doi.org/10.4103/jid.jid_21_23.

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ABSTRACT Background: Titanium-prepared platelet-rich fibrin (T-PRF), a new autologous platelet-rich fibrin (PRF) product, is based on the hypothesis that titanium tubes may be more effective in activating platelets when compared with Choukroun’s leukocyte and PRF (L-PRF) method. In this study, we aimed to define the structural characteristics under scanning electron microscopy of T-PRF and compare it with L-PRF. Materials and Methods: Blood samples were collected from 10 healthy volunteers. The blood samples were drawn using a 10 ml syringe. A volume of 9 ml was transferred to a dry glass tube

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Tunalı, Mustafa, Hakan Özdemir, Zafer Küçükodacı, et al. "A Novel Platelet Concentrate: Titanium-Prepared Platelet-Rich Fibrin." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/209548.

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We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun’s leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, we aimed to define the structural characteristics of T-PRF and compare it with L-PRF. Blood samples were collected from 10 healthy male volunteers. The blood samples were drawn using a syringe. Nine milliliters was transferred to a dry glass tube, and 9 mL was transferred to a tita

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Aizawa, Hachidai, Tetsuhiro Tsujino, Taisuke Watanabe, et al. "Quantitative Near-Infrared Imaging of Platelets in Platelet-Rich Fibrin (PRF) Matrices: Comparative Analysis of Bio-PRF, Leukocyte-Rich PRF, Advanced-PRF and Concentrated Growth Factors." International Journal of Molecular Sciences 21, no. 12 (2020): 4426. http://dx.doi.org/10.3390/ijms21124426.

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Platelet-rich fibrin (PRF) is a fibrin matrix enriched with platelets. The PRF matrix is thought to form a steep gradient of platelet density around the region corresponding to the buffy coat in anticoagulated blood samples. However, this phenomenon has not yet been proven. To visualize platelet distribution in PRF in a non-invasive manner, we utilized near-infrared (NIR) imaging technology. In this study, four types of PRF matrices, bio-PRF, advanced-PRF (A-PRF), leukocyte-rich PRF (L-PRF), and concentrated growth factors (CGF) were compared. Blood samples collected from healthy, non-smoking

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Pandey, Jayati, Rashmeet Nagpal, Dakshita Joy Sinha, and Aditya Gupta. "Clinical efficacy of platelet-rich fibrin, injectable platelet-rich fibrin, and advanced platelet-rich fibrin in regenerative endodontics: A case series." Journal of Conservative Dentistry and Endodontics 27, no. 11 (2024): 1196–200. http://dx.doi.org/10.4103/jcde.jcde_500_24.

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Background: This series investigates the efficacy of regenerative endodontic therapy (RET) using various platelet-rich fibrin (PRF) formulations in treating apical periodontitis and necrotic pulp in immature permanent teeth. Aim: This study aims to evaluate the effectiveness of different PRF formulations in RET. Materials and Methods: Three cases involving patients aged 15–16 with immature teeth and necrotic pulp were treated with RET using PRF, injectable PRF, and advanced PRF. The procedure included inducing bleeding with a Hedstrom file, applying PRF variants, and sealing with mineral triox

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Makkad, Ramanpal Singh. "Platelet-rich fibrin and titanium-prepared platelet-rich fibrin in endoperio lesion management." Bioinformation 19, no. 1 (2023): 133–37. http://dx.doi.org/10.6026/97320630019133.

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Endo-perio lesions involve a variety of therapy choices that will lead to the best possible elimination of infection. Various therapy approaches have been investigated for curing of patients affected by endo-perio abnormalities. One of the second-generation platelet derivatives is plasma enriched with platelet (PRP).They may aid in the healing of wounds. Enhanced with platelets cells and several growth factors, platelet-rich fibrin (PRF) promotes repair and healing and regeneration of tissue at the periapical area. Platelet cell and leukocyte cell enriched fibrin, prepared in conjunction with

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Shanmugam, Shankar, Shankar Iyer, Syed Khalid Althaf, et al. "Platelet-rich Fibrin – A Narrative Review." Dentistry and Medical Research 11, no. 2 (2023): 49–57. http://dx.doi.org/10.4103/dmr.dmr_47_22.

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Abstract Platelets play a crucial role in the hemostasis and wound healing process. Platelets synthesize growth factors that activate cells such as fibroblasts, macrophages, and mesenchymal cells which are trapped within the fibrin matrix and promote wound healing. Platelet-rich fibrin (PRF) contains a human blood protein and it is composed of a tetra molecular structure with cytokines, platelets, and stem cells which act as biodegradable scaffold tissue regenerating cells. PRF is a healing biomaterial with no inflammatory reactions which can be used alone or in combination with bone grafts. T

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Uike, Suvidha, Rajvir Malik, and Apoorva Vinayak Salve. "Platelet-rich fibrin: A promising regenerative material." Journal of Global Oral Health 6 (June 26, 2023): 55–58. http://dx.doi.org/10.25259/jgoh_33_2022.

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Periodontal regeneration is a process involving biological events such as cell adhesion, migration, proliferation, and differentiation in an orchestrated sequence. It is well known that platelets play a key role in hemostasis and the wound healing process. Platelets were introduced as regenerative potential. Choukroun et al. (2001) first described platelet-rich fibrin (PRF). It is the second generation of platelet concentration. It consists of a natural fibrin matrix. It is autogenous fibrin made up of the patient’s blood free from anticoagulants. It is three-dimensional architecture consistin

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Bhangdiya, Kapil, Anand Wankhede, Priyanka Paul Madhu, and Amit Reche. "An overview on platelet concentrates in tissue regeneration in periodontology." AIMS Bioengineering 10, no. 1 (2023): 53–61. http://dx.doi.org/10.3934/bioeng.2023005.

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<abstract> <p>Recent research on the use of platelet concentration in medicinal dentistry has enhanced the potential for tissue regeneration. The ability of platelets to enhance tissue regeneration by using different forms of platelet concentration (blood component) such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), standard platelet-rich fibrin, advanced platelet-rich fibrin, etc. PRP became widely used once its potential for tissue regeneration was discovered; however, the use of anticoagulants restricted the easy use of PRP as compared to PRF; however, after the dis

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Andrei, Cătălin, Cristian Comănescu, Ion Pătraşcu, Viorel Perieanu, and Mădălina Perieanu. "Reducing edentulous ridge resorption by using PRF (Platelet Rich-Fibrin). Clinical case." Romanian Journal of Stomatology 62, no. 1 (2016): 5–9. http://dx.doi.org/10.37897/rjs.2016.1.1.

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Platelet rich-fibrin (PRF) is the ideal material for hard tissue augmentation after tooth extraction. It is based on patient’s fibrin and platelets and represents the main matrix of osteogenesis. The new A-PRF (Advanced-PRF) consists of monocytes that enrich the fibrin clot. These preparations certain growth factors and cytokines gradually released from the fibrin clot. This is the secret of osteogenesis process in PRF techniques of preserving the alveolar ridge.

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Shevchenko, S. N., and M. V. Rublenko. "Histological characteristics of Platelet-Rich Fibrin clots obtained under various modes of blood centrifugation." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 22, no. 99 (2020): 84–93. http://dx.doi.org/10.32718/nvlvet9914.

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Autologous products of the first and second generation, namely platelet-rich plasma and platelet-rich fibrin, are considered promising for regenerative medicine. They differ from each other in physical properties, as well as in the way they are obtained. The key procedure of all techniques is centrifugation; changing its parameters affects the biological properties of these biomaterials. The aim of the work is to determine and histologically characterize the area of concentration cells of autologous fibrin enriched with platelets, depending on the change in centrifugation parameters. The studi

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Gundawar, Satwik Sham, Sudhindra Baliga, Nilima Thosar, and Nilesh Rathi. "Platelet Rich Fibrin in Dentistry." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 4, no. 3 (2018): 01–12. http://dx.doi.org/10.53555/nnmhs.v4i3.611.

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Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. In the present review article, the evolution, preparation of PRF has been described. Autologous PRF is considered to be a healing biomaterial, which has its numerous applications in various disciplines of dentistry.

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Kui, Róbert, Judit Vasas, Győző Szolnoki, and Lajos Kemény. "Successful treatment of venous leg ulcer with platelet-rich fibrin." Bőrgyógyászati és Venerológiai Szemle 96, no. 6 (2020): 303–6. http://dx.doi.org/10.7188/bvsz.2020.96.6.1.

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The autologous platelet-rich blood derivatives have been used in bioregenerative medicine for decades in various indications including the facilitation of wound healing. Leukocyte- and platelet-rich fibrin (PRF) is a second-generation autologous blood-derived product, which can be obtained relatively easily and at low cost. PRF is rich in growth factors and antimicrobial proteins that are released by activated platelets and leukocytes. The authors present a successful treatment of a venous leg ulcer providing a detailed presentation of the PRF method.

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Simões-Pedro, Mara, Pedro Maria B. P. S. Tróia, Nuno Bernardo Malta dos Santos, António M. G. Completo, Rogerio Moraes Castilho, and Gustavo Vicentis de Oliveira Fernandes. "Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation." Polymers 14, no. 7 (2022): 1392. http://dx.doi.org/10.3390/polym14071392.

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Predictable outcomes intended by the application of PRF (platelet-rich fibrin) derivative membranes have created a lack of consideration for their consistency and functional integrity. This study aimed to compare the mechanical properties through tensile strength and analyze the structural organization among the membranes produced by L-PRF (leukocyte platelet-rich fibrin), A-PRF (advanced platelet-rich fibrin), and A-PRF+ (advanced platelet-rich fibrin plus) (original protocols) that varied in centrifugation speed and time. L-PRF (n = 12), A-PRF (n = 19), and A-PRF+ (n = 13) membranes were sub

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Pham, Thuy Anh Vu, Hao TT Nguyen, My TN Nguyen, et al. "Platelet-rich Fibrin Influences on Proliferation and Migration of Human Gingival Fibroblasts." International Journal of Experimental Dental Science 5, no. 2 (2016): 83–88. http://dx.doi.org/10.5005/jp-journals-10029-1131.

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ABSTRACT Aims Our study focused on the fabrication of platelet-rich fibrin (PRF) and evaluated its influences on cell behaviors, including proliferation and migration. Materials and methods Platelet-rich fibrin was prepared from human peripheral blood according to Choukroun's method without using nonanticoagulant and foreign factors for platelet activation. Platelet-rich fibrin architecture was studied by hematoxylin and eosin staining. The investigation of PRF effects on human gingival fibroblasts (hGFs) was conducted via PRF liquid extract. Cell proliferation was determined via the number of

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Sağsöz, Aslı, and Filiz Acun Kaya. "Use of platelet-rich fibrin (PRF) in the periodontology: A Review." Journal of Medical and Dental Investigations 4 (June 1, 2023): e230317. http://dx.doi.org/10.5577/jomdi.e230317.

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Platelets play an essential role in wound healing and periodontal regeneration, so using platelet concentrates can speed up wound healing after periodontal treatment. Platelet-rich fibrin (PRF), an autogenous concentrated blood product, is a fibrin matrix comprising molecular and cellular elements that allow for optimum improvement and PRF also increases the production of osteoprotegerin, which causes osteoblast proliferation and acts as an osteoconductive and osteoinductive material, initiating bone regeneration. Platelet-rich plasma (PRP) and PRF are platelet concentrates prepared from the p

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Tuţă, Alexandra Mihaela, Valentin Daniel Sîrbu, Ioan Sîrbu, and Ştefan Nichita. "Platelet rich fibrin (PRF) in oral implantology. Case study." Romanian Journal of Stomatology 61, no. 4 (2015): 271–76. http://dx.doi.org/10.37897/rjs.2015.4.3.

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Dental implant therapy based on osseointegration has known a big expansion in dentistry in the last years. Dental implant rehabilitation is a common procedure in restoring partial or total edentulous pacients in our days. A problem regarding implant rehabilitation appears when the pacient doesn’t have enought bone to allow implant insertion in safety conditions. In this cases the clinician has to turn to complementary interventions in order to improve bone width and height so that implants could be inserted. One of the most known procedures is guided bone regeneration (GBR – guided bone regene

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Pham, Thuy Anh Vu. "Comparison of Antimicrobial Activity against Porphyromonas gingivalis between Advanced Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin." International Journal of Biomaterials 2023 (March 27, 2023): 1–7. http://dx.doi.org/10.1155/2023/9194868.

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Platelet-rich fibrin (PRF) obtained via low-speed centrifugation has antimicrobial properties. This study was conducted to evaluate the effectiveness of advanced platelet-rich fibrin plus (A-PRF+) and injectable platelet-rich fibrin (I-PRF), obtained from patients with different periodontal states, against Porphyromonas gingivalis. A-PRF+ and I-PRF samples were obtained from venous blood of 60 subjects divided equally into three groups: periodontitis, gingivitis, and healthy gingiva groups. The antibacterial experiments evaluated biofilm inhibition, mature biofilm impact, and time-kill kinetic

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Chenchev, Ivan L., Vasilena V. Ivanova, Deyan Z. Neychev, and Radka B. Cholakova. "Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report." Folia Medica 59, no. 3 (2017): 362–66. http://dx.doi.org/10.1515/folmed-2017-0044.

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AbstractBackground:Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology.Aim: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF).Materials and methods:An 18 year-old

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Sudrajat, Nandang, Bimanda Rizki Nurhidayat, Oggy Satriya Putra, Rozalina Loebis, and Ismi Zuhria. "Relation between Blood Parameters and Platelet-Rich Fibrin Membrane Size for Ocular Graft." NeuroQuantology 20, no. 4 (2022): 454–59. http://dx.doi.org/10.14704/nq.2022.20.4.nq22258.

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Purpose: To investigate the relationship between blood parameters and platelet-rich fibrin (PRF) membrane size for ocular graft. Methods: Total of 12 New Zealand white rabbits, 6.5 ml of blood samples was taken for each rabbit, including 5 ml for platelet-rich fibrin membrane production using L-PRF protocol (centrifugation at 2700 rpm for 12 minutes) 1.5 ml for evaluation of blood parameters. Measurement of blood parameters consists of fibrinogen, haemoglobin, hematocrit, red blood cell (RBC), white blood cell (WBC) and platelet. Measurement of the platelet-rich fibrin membrane area was done u

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Lana, José Fábio, Joseph Purita, Peter Albert Everts, et al. "Platelet-Rich Plasma Power-Mix Gel (ppm)—An Orthobiologic Optimization Protocol Rich in Growth Factors and Fibrin." Gels 9, no. 7 (2023): 553. http://dx.doi.org/10.3390/gels9070553.

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Platelet- and fibrin-rich orthobiologic products, such as autologous platelet concentrates, have been extensively studied and appreciated for their beneficial effects on multiple conditions. Platelet-rich plasma (PRP) and its derivatives, including platelet-rich fibrin (PRF), have demonstrated encouraging outcomes in clinical and laboratory settings, particularly in the treatment of musculoskeletal disorders such as osteoarthritis (OA). Although PRP and PRF have distinct characteristics, they share similar properties. The relative abundance of platelets, peripheral blood cells, and molecular c

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Cid, Felipe. "Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review." International Journal of Medical and Surgical Sciences 4, no. 3 (2018): 1196–202. http://dx.doi.org/10.32457/ijmss.2017.020.

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Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second ge

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Khiste, Sujeet Vinayak, and Ritam Naik Tari. "Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration." ISRN Biomaterials 2013 (June 6, 2013): 1–6. http://dx.doi.org/10.5402/2013/627367.

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Wound healing is a staged process which involves the activity of leukocytes and platelets. For this process to work efficiently, the platelets play a vital role. The growth factors present in platelets are important to guide the regenerating cells to the area of healing. Platelet-rich-fibrin (PRF) is one such material that holds on to these growth factors enmeshed in the fibrin network resulting in their sustained release over a period of time that can accelerate the wound healing process. With this knowledge, research has been carried out for a past few years for the clinical application of P

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Kumar, Ajin S., Syam K. Venugopal, Laiju M, et al. "Preparation of canine platelet rich fibrin membrane and its characterisation using light microscopy and scanning electron microscopy." Journal of Veterinary and animal sciences 55, no. 4 (2024): 698–703. https://doi.org/10.51966/jvas.2024.55.4.698-703.

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The current study was undertaken to analyse the cellular components and three-dimensional organisation of “platelet rich fibrin” membrane (PRFM), an autologous blood derived biomaterial. Ten millilitres of whole blood collected from six canine patients which was then centrifuged at 542.4G (3200 rpm for 10 minutes). The PRF clot thus obtained was pressed to form the platelet rich fibrin membrane (PRFM). The structural analysis and cell composition of PRFM was analysed using scanning electron microscopy (SEM) and histopathology. Evaluation with SEM revealed clearly organised fibrin in parallel s

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Parihar, Anuj Singh, Sumit Narang, Shivani Dwivedi, Anu Narang, and Sweta Soni. "Platelet-Rich Fibrin for Root Coverage." Annals of African Medicine 20, no. 3 (2021): 241–44. http://dx.doi.org/10.4103/aam.aam_31_20.

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Predictable esthetic root coverage has evolved into conventional treatment modalities making cosmetic procedures an integral part of periodontal treatment. The advent of second-generation platelet concentrates, i.e., platelet-rich fibrin (PRF), has broad clinical application in medical as well as dental field with its recent use for recession defects. The simplicity of PRF procurement and its low cost makes it most suitable for use in daily clinical practice. This particular case report foregrounds the benefit of PRF membrane along with coronally repositioned flap for mucogingival surgery on t

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RANI, N., MK SHAHZAD, T. HASSAN, N. HANIF, M. ULLAH, and F. HUMERA. "COMPARING THE EFFICACY OF INJECTABLE PLATELET-RICH FIBRIN (I-PRF) WITH PLATELET-RICH PLASMA (PRP) IN THE TREATMENT OF ANDROGENIC ALOPECIA." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1353. https://doi.org/10.54112/bcsrj.v2024i1.1353.

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Androgenic alopecia (AGA) is a common form of hair loss affecting both men and women worldwide. Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) have emerged as promising therapies for AGA due to their regenerative properties. Aim and Objective: This study compared the efficacy of injectable platelet-rich fibrin (I-PRF) with platelet-rich plasma (PRP) in treating androgenic alopecia to determine which treatment modality yields superior hair growth outcomes in AGA patients. Methods: This randomized controlled trial was conducted at Sheikh Zayed Hospital Rahim Yar Khan from January 2024

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Santana, Ilan Hudson Gomes de, Mayara Rebeca Martins Viana, Edmundo Junio Rodrigues de Almeida, et al. "Bibliometric survey from 1964 to 2023 on the applications of platelet and leukocyte rich fibrin (L-PRF) in oral and maxillofacial surgery." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 17, no. 8 (2024): e9646. http://dx.doi.org/10.55905/revconv.17n.8-326.

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Introduction: L-PRF is an autologous biomaterial composed of fibrin rich in platelets and leukocytes, which has remarkable potential for promoting tissue regeneration in surgical procedures. Materials and Methods: An exploratory and descriptive bibliometric study was carried out, using a quantitative and statistical approach. The aim was to identify indicators of academic activity related to the applications of platelet- and leukocyte-rich fibrin (L-PRF) in oral and maxillofacial surgery and trauma. Initially, 1811 studies were identified that dealt with the specific applications of L-PRF in t

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Moergel, Maximilian. "A Mini-review on the Impact of PlateletRich Fibrin on the Thickness and Width of keratinized Mucosa." Open Access Journal of Dental and Oral Surgery (OAJDOS) 3, no. 1 (2022): 1–4. http://dx.doi.org/10.54026/oajdos/1027.

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Objectives The present mini-review compares the effect of different forms of platelet-rich fibrin (PRF) utilized for soft tissue management on width and depth of keratinized mucosa. Materials and methods The Pubmed database was screened in January 2022 to find randomized controlled clinical trials examining the effect on soft tissue thickness and width by plateled-rich fibrin (PRF). In the preliminary search the following keywords were used in combination with the keyword „PRF“: “AND mucosa”, “AND keratinized mucosa”, “AND socket preservation”, “ AND recession”,and “implants”. Results During t

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Zhang, Mingming, Yong Tai, and Le Chen. "Clinical and Radiographic Evaluation of Combined Treatment with Bisphosphonate Plus Platelet-Rich Fibrin versus Platelet-Rich Fibrin Alone for Severe Periodontitis with Furcation Defects." Journal of Biomaterials and Tissue Engineering 10, no. 7 (2020): 1029–34. http://dx.doi.org/10.1166/jbt.2020.2363.

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Background: This research assessed the clinical and radiographic evaluation of treatment with PRF plus bisphosphonate, compared to alone PRF in treatment of severe periodontitis with furcation defects. Methodology : This randomized, controlled radiological and clinical study enrolled 50 patients. All patients were given oral health instructions, oral prophylaxis, root planning, and relief of trauma from occlusion. The sites for therapy with PRF and PRF plus bisphosphonate were chosen randomly by the coin toss method. After they had received 6 weeks of presurgical therapy, patients underwent fu

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Chenna, Deepika, Shamee Shastry, and Soumya Das. "Cocktail Protocol for Preparation of Platelet-Rich Fibrin Glue for Autologous Use." Malaysian Journal of Medical Sciences 28, no. 1 (2021): 35–40. http://dx.doi.org/10.21315/mjms2021.28.1.5.

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Background: Biomaterials containing platelets have been used to promote healing of ulcers and burns, as well as in implantology and maxillofacial and plastic surgery to achieve wound healing and tissue repair. Commercial devices to prepare autologous biomaterials involve diverse preparation methods that can have high production costs and low yields. Hence, we designed a protocol for preparation of large amounts of autologous platelet-rich fibrin (PRF) glue using conventional processing techniques for blood components. Methods: Autologous whole blood collected 72 h before surgery was processed

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Ngah, Nurul Aida, George J. Dias, Darryl C. Tong, et al. "Lyophilised Platelet-Rich Fibrin: Physical and Biological Characterisation." Molecules 26, no. 23 (2021): 7131. http://dx.doi.org/10.3390/molecules26237131.

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Background: Platelet-rich fibrin (PRF) has gained popularity in craniofacial surgery, as it provides an excellent reservoir of autologous growth factors (GFs) that are essential for bone regeneration. However, the low elastic modulus, short-term clinical application, poor storage potential and limitations in emergency therapy use restrict its more widespread clinical application. This study fabricates lyophilised PRF (Ly-PRF), evaluates its physical and biological properties, and explores its application for craniofacial tissue engineering purposes. Material and methods: A lyophilisation metho

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MOHAMMED, Jiyar. "Efficacy of Platelet Rich Fibrin on Angiogenesis." Journal of Duhok University 23, no. 1 (2020): 172–77. http://dx.doi.org/10.26682/csjuod.2020.23.1.18.

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In this experiment we used platelet-rich fibrin (L-PRF) with the protocol of its production, in this study we tried to investigate the angiogenetic efficacy of L-PRF on s soft tissue. Blood samples of 8 sheep were used to establish the protocol of the L-PRF formation to develop the work. The mucoperiosteal flaps were filled with autologous L-PRF in the mandible and maxillary jaws of the sheep. Samples taken from the surgical sites stained with haematoxylin and eosin for diagnosis of the sections, then immunohistological tests were confirmed on these sections. We noticed that after 14 days of m

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Tuczyńska, Magdalena, Martyna Zamaro, and Teresa Matthews-Brzozowska. "The use of platelet-rich fibrin in dental aesthetics." Journal of Face Aesthetics 5, no. 2 (2023): 111–18. http://dx.doi.org/10.20883/jofa.62.

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Introduction. Appearance is an important element of both the physical and psychological spheres of a person. Clinicians are increasingly using platelet‑rich fibrin (PRF) in aesthetic medicine procedures. PRF can be used to improve the smile with great success. Aim. The aim of this study is to present the latest reports on the use of platelet‑rich fibrin in smile aesthetics from the last 5 years. Material and methods. Online databases were searched by typing the keyword platelet‑rich fibrin and adding words with treatments used in smile aesthetics. The time interval was defined as between 2017–

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Fatemeh Mohammadian and Saeid Sahraei. "Comparative Evaluation of Blood Clot, Platelet-Rich Plasma, and Platelet-Rich Fibrin Scaffolds in the Success of Regenerative Endodontic Treatments: A Literature Review." Journal of Medical and Health Studies 6, no. 1 (2025): 109–14. https://doi.org/10.32996/jmhs.2025.6.1.15.

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The use of natural scaffolds in regenerative endodontic treatments can significantly impact treatment outcomes. Natural scaffolds such as Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), and blood clot are effective in improving clinical symptoms, resolving periapical lesions, regenerating dentin structure, closing the root apex, and increasing root length in regenerative endodontic treatments. This study aims to provide a comparative evaluation of blood clot, platelet-rich plasma (PRP), and platelet-rich fibrin (PRF) as natural scaffolds in the success of regenerative endodontic treatm

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Makki, Alaa Z., Anoud M. Alsulami, Arwa S. Almatrafi, Moroj Z. Sindi, and Shahinaz N. Sembawa. "The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery." International Journal of Dentistry 2021 (May 8, 2021): 1–9. http://dx.doi.org/10.1155/2021/6686857.

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Background and Purpose. Some physiological changes may occur following tooth extraction, and symptoms during the postextraction period may affect the patient’s quality of life. Many techniques have been developed to improve postextraction pain and soft tissue healing. Accordingly, this study will compare the postextraction pain and early soft tissue healing characteristics of extraction sites treated with leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). The aim is to evaluate the effect of advanced PRF in comparison with L-PRF on soft tissue healing and pain af

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Rasajnam, Neethu, Sreejith Kalathummarathu, Shehadad Kammili, and Sreedevi Menon. "Clinical Outcome of Chronic Leg and Foot Ulcers Treated with Autologous Platelet Rich Fibrin." Journal of Evolution of Medical and Dental Sciences 11, no. 1 (2022): 33–38. http://dx.doi.org/10.14260/jemds/2022/7.

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BACKGROUND Chronic leg and foot ulcers are a major health problem and leads to negative physical, social and psychological impact on patients and families. A high percentage of chronic ulcers do not adequately heal or quickly relapse with conventional treatment. They need advanced treatment modalities. Emerging cellular therapies such as platelet-rich concentrate therapy is an advanced modality. Platelet rich fibrin (PRF) is a second-generation platelet concentrate, consists of fibrin three-dimensional polymerized matrix, with the incorporation of platelets and leukocytes. The objective of the

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Mónica Alexandra Acosta Vargas, Mónica Alexandra Acosta Vargas, Ronald Medardo Gómez Coba, Jhoseline Melissa Pérez Villacrés, and Mónica Sofía Pallo Sarabia. "Comparative study between physiological healing vs. the use of platelet-rich fibrin at the time of bone and gingival tissue healing in lower third molar surgeries. Bibliographic Review." Interamerican Journal of Health Sciences 4 (July 11, 2024): 122. http://dx.doi.org/10.59471/ijhsc2024122.

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Introduction: The extraction of retained third molars can present surgical complications, causing various alterations to the patient, such as pain after the intervention, inflammation during the next 24 to 72 hours, jaw pain, among others. Objective: To compare the effectiveness of physiological healing vs. the use of platelet-rich fibrin at the time of bone and gingival tissue healing in lower third molar surgeries by means of a bibliographic review and thereby identify the properties and factors that promote healing. cicatrization. Materials and methods: Qualitative and descriptive bibliogra

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Adarsh Desai, Adarsh Desai, Nirav Patel Nirav Patel, Aditi Singh Aditi Singh, Sumaiyya Patel Sumaiyya Patel, Ritu Chhatbar Ritu Chhatbar, and Harsh Bhatt Harsh Bhatt. "The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration." Journal of Medical and Dental Science Research 12, no. 5 (2025): 36–40. https://doi.org/10.35629/076x-12053640.

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Androgenetic alopecia (AGA) is a prevalent condition that causes progressive hair thinning and loss, affecting both men and women. Despite existing treatments, their efficacy is inconsistent, leading to the exploration of alternative therapies. Recent advances in regenerative medicine, especially platelet-rich fibrin (PRF), show promise for stimulating hair regrowth. Specifically, injectable platelet-rich fibrin (i-PRF) and advanced plateletrich fibrin (A-PRF) have been highlighted for their potential in AGA management. This article explores their roles, mechanisms, clinical efficacy, and pote

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Adarsh Desai, Adarsh Desai, Nirav Patel Nirav Patel, Aditi Singh Aditi Singh, Sumaiyya Patel Sumaiyya Patel, Ritu Chhatabar Ritu Chhatabar, and Harsh Bhatt Harsh Bhatt. "The Role of injectable platelet-rich fibrin(i-PRF) and Advanced platelet-rich fibrin(A-PRF) in Androgenetic Alopecia: A New Frontier in Hair Regeneration." Journal of Medical and Dental Science Research 12, no. 6 (2025): 01–05. https://doi.org/10.35629/076x-12060105.

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Androgenetic alopecia (AGA) is a prevalent condition that causes progressive hair thinning and loss, affecting both men and women. Despite existing treatments, their efficacy is inconsistent, leading to the exploration of alternative therapies. Recent advances in regenerative medicine, especially platelet-rich fibrin (PRF), show promise for stimulating hair regrowth. Specifically, injectable platelet-rich fibrin (i-PRF) and advanced plateletrich fibrin (A-PRF) have been highlighted for their potential in AGA management. This article explores their roles, mechanisms, clinical efficacy, and pote

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Arnab, Pradhan, Karmakar Sanjoy, Mandal Saptarshi, Das Samiran, and Niyogi Soumadip. "Platelet-rich fibrin: Revolutionary boon to implant dentistry." Journal of Orofacial Rehabilitation 2, no. 2 (2022): 37–44. https://doi.org/10.5281/zenodo.6986618.

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<strong>Abstract</strong> Graft materials are utilized as scaffolds in defective surgical areas. Although, introducing platelet-rich fibrin (PRF) has multiple advantages over bone graft materials. PRF is a self generated biomaterial. It consists of growth factors or GFs and cytokines. It coalesces the fibrin sealing properties and GFs. This gives a classic condition for tissue regeneration and healing of the wound. The significant advantage of PRF is utilizes as self generated blood without extraneous thrombin. So, there is no immunogenic reaction. This article portrays the advanced applicatio

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Ghanaati, Shahram, Patrick Booms, Anna Orlowska, et al. "Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Inflammatory Cells." Journal of Oral Implantology 40, no. 6 (2014): 679–89. http://dx.doi.org/10.1563/aaid-joi-d-14-00138.

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Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants. In this study, protocols for standard platelet-rich fibrin (S-PRF) (2700 rpm, 12 minutes) and advanced platelet-rich fibrin (A-PRF) (1500 rpm, 14 minutes) were compared to establish by histological cell detection and histomorphometrical measurement of cell distribution the effects of the centrifugal force (speed and time) on the distribution of cells relevant for wound healing and tissue regeneration. Immunohistochemistry for monocytes, T and B -lymphocytes, neutrophilic granulocytes, CD34-positive ste

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Caruana, Andrea, Daniele Savina, José Paulo Macedo, and Sandra Clara Soares. "From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery." European Journal of Dentistry 13, no. 02 (2019): 280–86. http://dx.doi.org/10.1055/s-0039-1696585.

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AbstractIn the past 20 years, the platelet concentrates have evolved from first-generation products, i.e., platelet-rich plasma (PRP) and plasma rich in growth factors to the second-generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). These autologous products with a higher leukocyte inclusion and flexible fibrin mesh act as a scaffold to increase cellular migration in the angiogenic, osteogenic, and antimicrobial potential of these biomaterials in tissue regeneration. In the second-generation platelet concentrates, the protocols are eas

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Bai, Meng-Yi, Vu Pham Thao Vy, Sung-Ling Tang, et al. "Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs." International Journal of Molecular Sciences 24, no. 16 (2023): 12608. http://dx.doi.org/10.3390/ijms241612608.

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In recent years, several types of platelet concentrates have been investigated and applied in many fields, particularly in the musculoskeletal system. Platelet-rich fibrin (PRF) is an autologous biomaterial, a second-generation platelet concentrate containing platelets and growth factors in the form of fibrin membranes prepared from the blood of patients without additives. During tissue regeneration, platelet concentrates contain a higher percentage of leukocytes and a flexible fibrin net as a scaffold to improve cell migration in angiogenic, osteogenic, and antibacterial capacities during tis

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Ranganathan, Aravindhan T. "Platelet-Rich Fibrin in the Treatment of Periodontal Bone Defects." Journal of Contemporary Dental Practice 15, no. 3 (2014): 372–75. http://dx.doi.org/10.5005/jp-journals-10024-1546.

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ABSTRACT Background Periodontitis is characterized by the formation of true pockets, bone loss and attachment loss. Various techniques have been attempted in the past to truly regenerate the lost periodontal structures, albeit with variable outcome. In this evolution, the technique being tried out widely is the use of platelet rich concentrates, namely platelet-rich fibrin (PRF). Case description In this report, we present a case of surgical treatment of osseous bone defects namely two walled crater and dehiscence treated in posterior teeth with autologously prepared platelet rich fibrin mixed

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Rathod, Aishwarya, Priyanka Jaiswal, and Deepika Masurkar. "Advanced platelet rich fibrin in periodontal regeneration." AIMS Bioengineering 10, no. 2 (2023): 175–82. http://dx.doi.org/10.3934/bioeng.2023012.

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<abstract> <p>Regenerating periodontal tissue is the main goal of periodontal therapy. Periodontal tissue regeneration involves the development of new bone, cement, and periodontal ligaments on damaged tooth root surfaces in order to restore anatomy and function. In order to further enhance PRF (Platelet rich fibrin) and develop advanced platelet-rich fibrin, a slower rotating speed is proposed (A-PRFs). Cell dispersion is affected by centrifugation rate. The majority of the leukocytes in the PRF are concentrated near the bottom of the tube due to centrifugation rate. By switching

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Abd Al-Hussein, Shahad S., Alaa A. I. Al-Dirawi, and Rafid M. N. Al-Khalifah. "Histopathological Study of the Effect of Xenogeneic Platelet-Rich Fibrin on Achilles Tendon Healing in Rabbit." Sumer 2 8, CSS 2 (2023): 1–10. http://dx.doi.org/10.21931/rb/css/2023.08.02.24.

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Tendon is a mechanical bridge that transforms the force generated by muscle contraction into movement. This tissue is well known for its low cellularity and vascularity; therefore, any tendon damage is characterized by a slow and inefficient healing process resulting in mechanically, structurally, and functionally inferior tissue. The current study aimed to evaluate the effect of the regenerative capacity of xenogeneic platelet-rich fibrin on the acceleration of Achilles tendon healing in rabbits. 24 adult rabbits weighing (1.5-2) kg were used in this study. The animals were divided equally in

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Kalaivani, Varatharajan, Vivek Narayanan, Potluri Leela Ravishankar, Kunga Mohan Ramkumar, Nizar Ahmed, and Divya Vinayachandran. "A Comparative Evaluation of Platelet-derived Growth Factor in a-PRF and a-PRF plus, with and without Low-level Laser Therapy – An Ex vivo Pilot Study." Journal of Indian Academy of Oral Medicine and Radiology 37, no. 1 (2025): 45–49. https://doi.org/10.4103/jiaomr.jiaomr_277_24.

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Background: The application of platelet concentrates has gained significant attention in regenerative medicine and dentistry, particularly in periodontal regenerative techniques. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates that facilitate the repair and regeneration of various tissues, attributed to their rich content of growth factors. Objectives: This current research aims at comparing the expression of platelet-derived growth factor (PDGF) from advanced platelet-rich fibrin (A-PRF) and advanced platelet-rich fibrin plus (A-PRF+), with and without appl

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Saravanakumar, R., M. Jananni, KR Vineela, and M. Sivaramakrishnan. "Platelet Rich Fibrin (PRF) in Periodontal Regeneration." Annals of SBV 3, no. 2 (2014): 14–20. http://dx.doi.org/10.5005/jp-journals-10085-3203.

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Mody, Dhawal, and Vrushali Lathiya. "Platelet Rich Fibrin in the Treatment of Localised Gingival Recession: A Case Report." International Journal of Research and Review 8, no. 5 (2021): 24–29. http://dx.doi.org/10.52403/ijrr.20210505.

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Root recession presents a matter of aesthetic concern in every dental practice. Also it may illicit sensitivity and is more prone to caries than the covered root surfaces. Platelet- rich fibrin is a second generation platelet concentrate. It is basically autologous leukocyte and platelet-rich fibrin biomaterial. The use of PRF in combination with coronally advanced flap in the treatment of gingival recession has shown promising results and is gaining immense popularity among the dental practitioners. This case reports the use of PRF membrane in root coverage on the labial surface of maxillary

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Sharma, Disha, Shobha Mohindroo, and Ramesh K. Azad. "Efficacy of platelet rich fibrin in myringoplasty." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 3 (2018): 677. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20181670.

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<p class="abstract"><strong>Background:</strong> Myringoplasty involves repair of tympanic membrane perforation with an autologous graft.The aim was to compare between myringoplasty with PRF and myringoplasty without fibrin.</p><p class="abstract"><strong>Methods:</strong> This study was conducted from July 2016 to June 2017,100 patients were taken. In 50 patients platelet rich fibrin was placed over graft and external auditory canal during myringoplasty and 50 without PRF. </p><p class="abstract"><strong>Results:</strong> It wa

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Rebimbas Guerreiro, Simão, Carlos Miguel Marto, Anabela Paula, et al. "Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review." International Journal of Molecular Sciences 26, no. 12 (2025): 5479. https://doi.org/10.3390/ijms26125479.

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Conventional endodontic treatment has several disadvantages, which lead to the introduction of regenerative endodontic procedures aiming to maintain tooth vitality. Platelet concentrates possess relevant biological properties, and their application has been explored in various endodontic procedures. The aim of this scoping review is to identify the applications of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in endodontics. To identify and map the types of studies, the protocols for obtaining PRF/PRP, the most productive authors, and the journals where most articles were published

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