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Journal articles on the topic 'Platelet-rich fibrin'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Avinash, Shashant, Gaurav Malhotra, Pradeep Shukla, and Prerna Kataria. "Autologous platelet rich fibrin." Asian Pacific Journal of Health Sciences 5, no. 3 (July 2018): 1–10. http://dx.doi.org/10.21276/apjhs.2018.5.3.1.

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Murray, Taryn, and Shilpi Khetarpal. "Platelet-Rich Fibrin." Advances in Cosmetic Surgery 5, no. 1 (May 2022): 9–16. http://dx.doi.org/10.1016/j.yacs.2021.12.001.

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3

Tuţă, Alexandra Mihaela, Valentin Daniel Sîrbu, Ioan Sîrbu, and Ştefan Nichita. "Platelet rich fibrin (PRF) in oral implantology. Case study." Romanian Journal of Stomatology 61, no. 4 (December 31, 2015): 271–76. http://dx.doi.org/10.37897/rjs.2015.4.3.

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Dental implant therapy based on osseointegration has known a big expansion in dentistry in the last years. Dental implant rehabilitation is a common procedure in restoring partial or total edentulous pacients in our days. A problem regarding implant rehabilitation appears when the pacient doesn’t have enought bone to allow implant insertion in safety conditions. In this cases the clinician has to turn to complementary interventions in order to improve bone width and height so that implants could be inserted. One of the most known procedures is guided bone regeneration (GBR – guided bone regeneration) wich consists in placing a membrane to the bone defects. Platelet rich fibrin (PRF – platelet rich fibrin) is a second generation platelet concentrate wich gives the clinician access to growth factors throught a simple and up to date technology. These growth factors wich are autologous, non-toxic and non-immunogenic enhance and accelerate normal bone regeneration pathways. (1)

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Katta, Prashanth Kumar. "Platelet Rich Plasma & Platelet Rich Fibrin: Dental Applications." Indian Journal of Contemporary Dentistry 4, no. 1 (2016): 44. http://dx.doi.org/10.5958/2320-5962.2016.00010.3.

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5

Vokurka, J., E. Gopfert, M. Blahutkova, E. Buchalova, and M. Faldyna. "Concentrations of growth factors in platelet-rich plasma and platelet-rich fibrin in a rabbit model." Veterinární Medicína 61, No. 10 (October 21, 2016): 567–70. http://dx.doi.org/10.17221/24/2016-vetmed.

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Jasmine, Sharmila, Annamalai Thangavelu, Rajapandiyan Krishnamoorthy, KhalidE Alzahrani, and MohammadA Alshuniaber. "Architectural and ultrastructural variations of human leukocyte-rich platelet-rich fibrin and injectable platelet-rich fibrin." Journal of Microscopy and Ultrastructure 9, no. 2 (2021): 76. http://dx.doi.org/10.4103/jmau.jmau_7_20.

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Gundawar, Satwik Sham, Sudhindra Baliga, Nilima Thosar, and Nilesh Rathi. "Platelet Rich Fibrin in Dentistry." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 4, no. 3 (March 31, 2018): 01–12. http://dx.doi.org/10.53555/nnmhs.v4i3.611.

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Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. In the present review article, the evolution, preparation of PRF has been described. Autologous PRF is considered to be a healing biomaterial, which has its numerous applications in various disciplines of dentistry.

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B, UthappaK, BSJagadish pai, AmitK W, and Sreelakshmi sekhar. "PLATELET-RICH FIBRIN: A REVIEW." International Journal of Advanced Research 5, no. 11 (November 30, 2017): 677–81. http://dx.doi.org/10.21474/ijar01/5819.

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Kumar, Yuvika Raj, Sujata Mohanty, Mahesh Verma, Raunaq Reet Kaur, Priyanka Bhatia, Varun Raj Kumar, and Zainab Chaudhary. "Platelet-rich fibrin: the benefits." British Journal of Oral and Maxillofacial Surgery 54, no. 1 (January 2016): 57–61. http://dx.doi.org/10.1016/j.bjoms.2015.10.015.

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10

Mohamed, Shahana C. "Platelet-Rich Fibrin: Role in Periodontal and Pulpal Regeneration." Journal of Medical Science And clinical Research 05, no. 05 (May 28, 2017): 22447–52. http://dx.doi.org/10.18535/jmscr/v5i5.190.

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Tunalı, Mustafa, Hakan Özdemir, Zafer Küçükodacı, Serhan Akman, Emre Yaprak, Hülya Toker, and Erhan Fıratlı. "A Novel Platelet Concentrate: Titanium-Prepared Platelet-Rich Fibrin." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/209548.

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We developed a new product called titanium-prepared platelet-rich fibrin (T-PRF). The T-PRF method is based on the hypothesis that titanium may be more effective in activating platelets than the silica activators used with glass tubes in Chouckroun’s leukocyte- and platelet-rich fibrin (L-PRF) method. In this study, we aimed to define the structural characteristics of T-PRF and compare it with L-PRF. Blood samples were collected from 10 healthy male volunteers. The blood samples were drawn using a syringe. Nine milliliters was transferred to a dry glass tube, and 9 mL was transferred to a titanium tube. Half of each clot (i.e., the blood that was clotted using T-PRF or L-PRF) was processed with a scanning electron microscope (SEM). The other half of each clot was processed for fluorescence microscopy analysis and light microscopy analysis. The T-PRF samples seemed to have a highly organized network with continuous integrity compared to the other L-PRF samples. Histomorphometric analysis showed that T-PRF fibrin network covers larger area than L-PRF fibrin network; also fibrin seemed thicker in the T-PRF samples. This is the first human study to define T-PRF as an autogenous leukocyte- and platelet-rich fibrin product. The platelet activation by titanium seems to offer some high characteristics to T-PRF.

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Badade, PallaviS, SwapnaA Mahale, AlishaA Panjwani, PruthaD Vaidya, and AyushyaD Warang. "Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin." Indian Journal of Dental Research 27, no. 3 (2016): 300. http://dx.doi.org/10.4103/0970-9290.186231.

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13

Nagaraja, Shruthi, Sylvia Mathew, Namrata Jain, Bhawna Jethani, Sharanya Nambiar, Mohini Kumari, and Soumya Nair. "Study of antibacterial and antifungal efficacy of platelet-rich fibrin and platelet-rich fibrin matrix." Journal of Conservative Dentistry 22, no. 5 (2019): 415. http://dx.doi.org/10.4103/jcd.jcd_100_19.

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14

Bashir, Samah, Najma Banoo, Ajaz Ahmad Shah, and Safeer Ahmad Malik. "Different applications of platelet rich fibrin in dentistry: A review." IP International Journal of Maxillofacial Imaging 8, no. 4 (December 15, 2022): 135–37. http://dx.doi.org/10.18231/j.ijmi.2022.032.

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Platelet rich fibrin contains various growth factors with in it and it is composed of fibrin matrix. Platelet rich fibrin is a concentrate of platelets of the second generation. Platelet rich fibrin helps in reducing the process of inflammation and enhance the healing process. An ideal environment is provided by platelet rich fibrin for the process of wound healing as well as regeneration of the tissue, as they combine the properties of fibrant sealant along with the properties of the growth factors in it. Platelet rich plasma has some advantages as it is derived more easily and with economical method of preparation along with it, it also eliminates the requirement of any exogenous compound for e.g. bovine thrombin or calcium chloride during the process of fabrication.

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Wahengbam, Prashanti, Nenavata Ravi, S. Bharathesh, Dimple Budhiraja, Neha Nandal, and Dania Fatima. "Various applications of platelet rich fibrin in dentistry: A literature review." Journal of Dental Panacea 3, no. 3 (November 15, 2021): 99–101. http://dx.doi.org/10.18231/j.jdp.2021.022.

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Platelet rich fibrin is a part of platelet concentrate, that is derived from human blood and made through the process of centrifugation. It is an autogeneous bio material, which basically constitutes various growth factors, and cytokines that are entrapped in its matrix of fibrin. Platelet rich fibrin provides ideal environment for healing of the wound and the regeneration of the tissue. Platelet rich fibrin helps in regulating the inflammation process and increases the healing process.

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Tuczyńska, Magdalena, Martyna Zamaro, and Teresa Matthews-Brzozowska. "The use of platelet-rich fibrin in dental aesthetics." Journal of Face Aesthetics 5, no. 2 (February 10, 2023): 111–18. http://dx.doi.org/10.20883/jofa.62.

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Introduction. Appearance is an important element of both the physical and psychological spheres of a person. Clinicians are increasingly using platelet‑rich fibrin (PRF) in aesthetic medicine procedures. PRF can be used to improve the smile with great success. Aim. The aim of this study is to present the latest reports on the use of platelet‑rich fibrin in smile aesthetics from the last 5 years. Material and methods. Online databases were searched by typing the keyword platelet‑rich fibrin and adding words with treatments used in smile aesthetics. The time interval was defined as between 2017–2022. Results. Twelve scientific articles on the use of platelet‑rich fibrin in bone defect regeneration, gingival recession coverage, bifurcation regeneration and tissue regeneration after tooth extractions were used. Conclusions. Platelet‑rich fibrin is widely used in dentistry and has the added value of being autologous.

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Gaßling, Volker L. W., Yahya Açil, Ingo N. Springer, Nina Hubert, and Jörg Wiltfang. "Platelet-rich Plasma and Platelet-rich fibrin in human cell culture." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 108, no. 1 (July 2009): 48–55. http://dx.doi.org/10.1016/j.tripleo.2009.02.007.

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18

Vaidyanathan, AnandKumar, Athiban Inbarajan, PadmanabhanThallam Veeravalli, MadhanKumar Seenivasan, Shanmuganathan Natarajan, Anusha Sathiamurthy, and RShakir Ahmed. "Platelet-rich plasma and platelet-rich fibrin as a regenerative tool." Journal of Pharmacy And Bioallied Sciences 13, no. 6 (2021): 1266. http://dx.doi.org/10.4103/jpbs.jpbs_74_21.

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19

Cid, Felipe. "Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review." International Journal of Medical and Surgical Sciences 4, no. 3 (October 27, 2018): 1196–202. http://dx.doi.org/10.32457/ijmss.2017.020.

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Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.

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Arunachalam, Muthukumaraswamy, Shaju J. Pulikkotil, and Nath Sonia. "Platelet Rich Fibrin in Periodontal Regeneration." Open Dentistry Journal 10, no. 1 (May 11, 2016): 174–81. http://dx.doi.org/10.2174/1874210601610010174.

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Periodontitis is a chronic bacterial infection resulting in destruction of the supporting structures of the teeth. Regeneration of the lost tissues has faced difficulties primarily due to the lack of support during the intricate healing processes. A surgical additive which can ‘jump start’ the healing process to a more predictable regenerative process is always on the wish list of any periodontist. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that has been considered to be an important, easy to obtain, predictable surgical additive for periodontal regeneration. This autologous scaffold provides the much needed bio-chemical mediators which has the potential for enhancing reconstruction of the periodontium. This review article tries to understand as to why PRF would be an important link to reach predictable periodontal regeneration.

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21

Koch, Felix P. "Platelet-Rich Fibrin in der Endodontie." Der Freie Zahnarzt 65, no. 12 (November 29, 2021): 58–59. http://dx.doi.org/10.1007/s12614-021-0239-9.

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Ruga, Emanuele, Cesare Gallesio, and Paolo Boffano. "Platelet-Rich Fibrin and Piezoelectric Surgery." Journal of Craniofacial Surgery 22, no. 5 (September 2011): 1951–55. http://dx.doi.org/10.1097/scs.0b013e31822ea76b.

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23

Karimi, Kian, and Helena Rockwell. "The Benefits of Platelet-Rich Fibrin." Facial Plastic Surgery Clinics of North America 27, no. 3 (August 2019): 331–40. http://dx.doi.org/10.1016/j.fsc.2019.03.005.

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24

Fu, Chun-Jiang, Jia-Bing Sun, Zheng-Gang Bi, Xu-Ming Wang, and Cheng-Lin Yang. "Evaluation of platelet-rich plasma and fibrin matrix to assist in healing and repair of rotator cuff injuries: a systematic review and meta-analysis." Clinical Rehabilitation 31, no. 2 (July 10, 2016): 158–72. http://dx.doi.org/10.1177/0269215516634815.

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Objective: To perform a meta-analysis examining the effectiveness of platelet-rich plasma and platelet-rich fibrin matrix for improving healing of rotator cuff injuries. Data sources/design: A meta-analysis of eligible studies was performed after searching Medline, Cochrane, and EMBASE on 14 December 2015. Setting: University hospital. Participants: Patients with rotator cuff injuries. Review methods/intervention: Databases were searched using the keywords “PRP or platelet-rich plasma,” “PRFM or platelet-rich fibrin matrix,” “rotator cuff,” and “platelet-rich” for studies comparing outcomes of patients with rotator cuff injuries that did and did not receive a platelet-rich product. Main measures: The primary outcome was a functional score change from pre- to post-treatment (Scorepost–Scorepre). The secondary outcome was a visual analogue scale (VAS) pain score change from pre- to post-treatment (VASpost–VASpre). Results: A total of 11 studies were included in the meta-analysis. The total number of patients that received platelet-rich plasma or platelet-rich fibrin matrix was 320 and the number of control patients was 318. The standard difference in means of the functional scores was similar between patients administered platelet-rich plasma/fibrin matrix and patients in the control group (standard difference in means for functional scores = 0.029; 95% confidence interval (CI): –0.132 to 0.190; p = 0.725). The standard difference in means was similar between patients administered platelet-rich plasma and the controls (standard difference in means = 0.142; 95% CI: –0.080 to 0.364; p = 0.209). Conclusion: The results of this meta-analysis do not support the use of platelet-rich plasma/platelet-rich fibrin matrix in patients with rotator cuff injuries.

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Agrawal, Shweta, Pramod Kumar Koirala, Shalini Pradhan, and Ranjita Shrestha Gorkhali. "Platelet Rich Fibrin as Wound Coverage of Donor Site in Free Gingival Graft." Journal of Nepalese Society of Periodontology and Oral Implantology 2, no. 1 (June 4, 2018): 26–29. http://dx.doi.org/10.3126/jnspoi.v2i1.23607.

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Free gingival graft is one of the technique used for root coverage so as to increase the inadequate keratinized tissue. The donor tissue is most frequently taken from the palate and generally the donor site is not covered or protected. Platelet rich fibrin is one of the good option for the wound coverage of donor site after free gingival graft so as to reduce the pain perception to patient and faster wound healing. The case report includes two cases with gingival recession, treated on the same day with free gingival graft with the use of platelet rich fibrin in the donor site in case 1 and without platelet rich fibrin in case 2 respectively which were compared for pain perception and wound healing postoperatively at 24 hours, 3 days, 5 days, 7 days and 14 days. There was less pain perception and discomfort in the donor site with the use of platelet rich fibrin and enhanced healing compared to donor site without platelet rich fibrin.

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Reed, Guy L., Gary R. Matsueda, and Edgar Haber. "Platelet Factor XIII Increases the Fibrinolytic Resistance of Platelet-Rich Clots by Accelerating the Crosslinking of α2-Antiplasmin to Fibrin." Thrombosis and Haemostasis 68, no. 03 (1992): 315–20. http://dx.doi.org/10.1055/s-0038-1656372.

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SummaryPlatelet clots resist fibrinolysis by plasminogen activators. We hypothesized that platelet factor XIII may enhance the fibrinolytic resistance of platelet-rich clots by catalyzing the crosslinking of α2-antiplasmin (α2AP) to fibrin. Analysis of plasma clot structure by polyacrylamide gel electrophoresis and immunoblotting revealed accelerated α2AP-fibrin crosslinking in platelet-rich compared with platelet-depleted plasma clots. A similar study of clots formed with purified fibrinogen (depleted of factor XIII activity), isolated platelets, and specific factor XIII inhibitors indicated that this accelerated crosslinking was due to the catalytic activity of platelet factor XIII. Moreover, when washed platelets were aggregated by thrombin, there was evidence of platelet factor XIII-mediated crosslinking between platelet α2AP and platelet fibrin(ogen). Specific inhibition (by a monoclonal antibody) of the α2AP associated with washed platelet aggregates accelerated the fibrinolysis of the platelet aggregate. Thus in platelet-rich plasma clots, and in thrombin-induced platelet aggregates, platelet factor XIII actively formed α2AP-fibrin crosslinks, which appeared to enhance the resistance of platelet-rich clots to fibrinolysis.

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Pham, Thuy Anh Vu, Hao TT Nguyen, My TN Nguyen, Van NL Trinh, Nga Y. Tran, Lan TQ Ngo, and Ha LB Tran. "Platelet-rich Fibrin Influences on Proliferation and Migration of Human Gingival Fibroblasts." International Journal of Experimental Dental Science 5, no. 2 (2016): 83–88. http://dx.doi.org/10.5005/jp-journals-10029-1131.

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ABSTRACT Aims Our study focused on the fabrication of platelet-rich fibrin (PRF) and evaluated its influences on cell behaviors, including proliferation and migration. Materials and methods Platelet-rich fibrin was prepared from human peripheral blood according to Choukroun's method without using nonanticoagulant and foreign factors for platelet activation. Platelet-rich fibrin architecture was studied by hematoxylin and eosin staining. The investigation of PRF effects on human gingival fibroblasts (hGFs) was conducted via PRF liquid extract. Cell proliferation was determined via the number of cells after a period of time incubated in PRF liquid extract. Influence of PRF liquid extract on the migration of hGFs was conducted via scratch wound healing assay. Results Histological staining reviewed the natural fibrin fiber matrix of PRF. Platelet-rich fibrin liquid extract promoted hGF proliferation after 7 days of cultivation. Human gingival fibroblast proliferation in PRF liquid extract was more superior than those cultured in complete medium. Platelet-rich fibrin was also found to be able to promote the migration of hGFs for up to 48 hours. Conclusion These results indicated that PRF is suitable to be used as autologous natural biomaterial in supporting wound healing and in further application in periodontitis treatments. How to cite this article Nguyen HTT, Nguyen MTN, Trinh VNL, Tran NY, Ngo LTQ, Pham TAV, Tran HLB. Platelet-rich Fibrin Influences on Proliferation and Migration of Human Gingival Fibroblasts. Int J Experiment Dent Sci 2016;5(2):83-88.

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Nour, Mohammad, and Reham Aggour. "Evaluation of the Efficacy of Leukocyte-Platelet Rich Fibrin versus Platelet Rich Fibrin Matrix on Bone Healing." Egyptian Dental Journal 64, no. 1 (January 1, 2018): 101–6. http://dx.doi.org/10.21608/edj.2017.77061.

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Singh, Pinky, Subhra Dey, Vinisha Pandey, Arora Abhas, Suprabha Sharan, and Neetu Kharat. "Antibacterial and antifungal efficacy of platelet-rich fibrin and platelet-rich fibrin matrix against root canal microflora." Journal of Pharmacy And Bioallied Sciences 13, no. 5 (2021): 124. http://dx.doi.org/10.4103/jpbs.jpbs_601_20.

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Ouyyamwongs, Warisara, Narit Leepong, and Srisurang Suttapreyasri. "Alveolar Ridge Preservation Using Autologous Demineralized Tooth Matrix and Platelet-Rich Fibrin Versus Platelet-Rich Fibrin Alone." Implant Dentistry 28, no. 5 (October 2019): 455–62. http://dx.doi.org/10.1097/id.0000000000000918.

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Abdallah Edrees, Mohamed F., Abdel Aziz B. Abdullah Baiomy, Hany G. Fahmy Gobran, and Hesham Ahmed Dameer. "Leukocyte platelet-rich fibrin versus platelet-rich fibrin block in ridge splitting technique with simultaneous implant placement." Egyptian Journal of Oral & Maxillofacial Surgery 8, no. 2 (May 2017): 32–37. http://dx.doi.org/10.1097/01.omx.0000515465.79426.e0.

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Mohan, SunilParamel, Nallusamy Jaishangar, Sandha Devy, Anjhana Narayanan, Deepthi Cherian, and SanupaSethu Madhavan. "Platelet-rich plasma and platelet-rich fibrin in periodontal regeneration: A review." Journal of Pharmacy And Bioallied Sciences 11, no. 6 (2019): 126. http://dx.doi.org/10.4103/jpbs.jpbs_41_19.

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Jhawar, Bhumika, Shirish Kujur, Vineeta Gupta, Hungyo Chanreiphy, and Pragya Kumari. "A neoteric platelet concentrate – Titanium-prepared platelet-rich fibrin." International Journal of Preventive and Clinical Dental Research 9, no. 4 (2022): 103. http://dx.doi.org/10.4103/ijpcdr.ijpcdr_26_22.

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Bhangdiya, Kapil, Anand Wankhede, Priyanka Paul Madhu, and Amit Reche. "An overview on platelet concentrates in tissue regeneration in periodontology." AIMS Bioengineering 10, no. 1 (2023): 53–61. http://dx.doi.org/10.3934/bioeng.2023005.

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<abstract> <p>Recent research on the use of platelet concentration in medicinal dentistry has enhanced the potential for tissue regeneration. The ability of platelets to enhance tissue regeneration by using different forms of platelet concentration (blood component) such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), standard platelet-rich fibrin, advanced platelet-rich fibrin, etc. PRP became widely used once its potential for tissue regeneration was discovered; however, the use of anticoagulants restricted the easy use of PRP as compared to PRF; however, after the discovery of PRF because of the easy formulation, it became widely used in medicinal dentistry. The purpose of this review is to elaborate on the importance of platelet concentration in periodontal regeneration.</p> </abstract>

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Girija, Kottuppallil, and Mahendran Kavitha. "Comparative evaluation of platelet-rich fibrin, platelet-rich fibrin + 50 wt% nanohydroxyapatite, platelet-rich fibrin + 50 wt% dentin chips on odontoblastic differentiation - An in vitro study-part 2." Journal of Conservative Dentistry 23, no. 4 (2020): 354. http://dx.doi.org/10.4103/jcd.jcd_3_20.

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Ranganathan, Aravindhan T. "Platelet-Rich Fibrin in the Treatment of Periodontal Bone Defects." Journal of Contemporary Dental Practice 15, no. 3 (2014): 372–75. http://dx.doi.org/10.5005/jp-journals-10024-1546.

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ABSTRACT Background Periodontitis is characterized by the formation of true pockets, bone loss and attachment loss. Various techniques have been attempted in the past to truly regenerate the lost periodontal structures, albeit with variable outcome. In this evolution, the technique being tried out widely is the use of platelet rich concentrates, namely platelet-rich fibrin (PRF). Case description In this report, we present a case of surgical treatment of osseous bone defects namely two walled crater and dehiscence treated in posterior teeth with autologously prepared platelet rich fibrin mixed with hydroxy apatite bone graft and PRF in the form of a membrane. Conclusion Our results showed clinical improvements in all the clinical parameters postoperatively namely the pocket depth reduction and gain in attachment level and hence, PRF can be used alone or in combination with the bone graft to yield successful clinical results in treating periodontal osseous defects. Clinical significance Platelet-rich fibrin is an effective alternative to platelet-rich plasma (PRP) in reconstructing bone defects. How to cite this article Ranganathan AT, Chandran CR. Platelet-Rich Fibrin in the Treatment of Periodontal Bone Defects. J Contemp Dent Pract 2014;15(3):372-375.

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Chenchev, Ivan L., Vasilena V. Ivanova, Deyan Z. Neychev, and Radka B. Cholakova. "Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report." Folia Medica 59, no. 3 (September 1, 2017): 362–66. http://dx.doi.org/10.1515/folmed-2017-0044.

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AbstractBackground:Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology.Aim: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF).Materials and methods:An 18 year-old male with expulsion of tooth 11 and partial fracture of the alveolar ridge was treated with augmentation of the alveolar ridge using bone graft material, injectable platelet–rich-fibrin(i-PRF) and advanced platelet-rich-fibrin (A-PRF). Clinical results were reviewed 4 months after the augmentation and a dental implant was placed.Results:The postoperative period was uneventful. The control CBCT scan showed good organization of new bone allowing placement of a dental implant.Conclusion:The successful clinical and radiographic results of the case suggest that using A-PRF and i-PRF can be beneficial for bone augmentation of the alveolar ridge before implant placement.

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Nair, Nithin, Arun Alexander, B. Abhishekh, Jyotirmay Hegde, Sivaraman Ganesan, and Sunil Saxena. "Safety and Efficacy of Autologous Platelet-rich Fibrin on Graft Uptake in Myringoplasty: A Randomized Controlled Trial." International Archives of Otorhinolaryngology 23, no. 01 (May 9, 2018): 077–82. http://dx.doi.org/10.1055/s-0038-1649495.

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Introduction Chronic suppurative otitis media is a common ailment in developing countries, and it generally presents with otorrhea and hearing loss. Different surgical procedures have been used to treat otitis media; among them is myringoplasty, which is a procedure that includes repair of the tympanic membrane. Platelet concentrates have been used widely in different types of wounds and are found to improve wound healing. Hence, the use of platelet-rich fibrin in myringoplasty will also improve the tympanic membrane healing. Objectives To assess the safety and efficacy of autologous platelet-rich fibrin on graft uptake in myringoplasty. Methods Eighty-six patients were observed during the study period of two years. Forty-three patients in the study group underwent myringoplasty aided with platelet-rich fibrin, and 43 patients in the control group went through the same procedure but without the platelet-rich fibrin. The patients were observed for three months postoperatively by a blinded observer. Results A total of 4.7% of the patients in the study group had postoperative infection, compared with a rate of 19% in the control group (p = 0.039). The graft uptake success rate was found to be 97.7% in the study group as compared with 81% in control group (p = 0.012). The results were found to be statistically significant. Conclusion Being autologous in nature, and by comparing the groups, platelet-rich fibrin is safe for patients. The postoperative graft uptake rate is better in cases in which platelet-rich fibrin was used. The postoperative infection rate was also lower in the same group.

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Csifó-Nagy, Boróka Klára, Claudia Paár, and Ferenc Dőri. "Vérlemezkében gazdag fibrinnel kezelt parodontalis csontdefektusok gyógyulásának értékelése." Orvosi Hetilap 163, no. 12 (March 20, 2022): 484–90. http://dx.doi.org/10.1556/650.2022.32391.

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Összefoglaló. Az autológ vérlemezke-koncentrátumok az orvoslás egyre több területén kerülnek alkalmazásra. A vérlemezkében gazdag fibrin, ebben a kategóriában, az adott terápiás lehetőségek közül a legaktuálisabb. Előnyei, hogy alvadásgátló hozzáadása nélkül preparálható, egy centrifugálást igényel, és több formában alkalmazható. A vérlemezkében gazdag fibrin újabb generációja további lehetőségeket teremthet, így a parodontalis sebgyógyulás terén is. Az esetek bemutatásának célja parodontalis intraossealis csontdefektusok gyógyulásának rövid távú klinikai értékelése autológ vérlemezkében gazdag készítménnyel (advanced platelet-rich fibrin) történt kezelést követően. A bemutatott eseteknél preoperatíven, majd 6 hónappal a műtétet követően történt kiértékelés a következő parodontológiai paraméterek rögzítésével: tasakszondázási mélység (probing depth), illetve klinikai tapadási szint (clinical attachment level). Teljes vastagságú lebenyek képzését követően a csontdefektus kürettálása, illetve gyökérsimítás történt, majd a preoperatíven preparált, vérlemezkében gazdag fibrin applikálására került sor, melyet sebzárás követett. Fél évvel a sebészi beavatkozás után a szondázási mélység csökkenése és a klinikai tapadási nívó növekedése volt tapasztalható. Bemutatott eseteinknél a vérlemezkében gazdag fibrin applikációja pozitív klinikai eredményeket mutatott a parodontalis sebgyógyulás tekintetében. A vérlemezkében gazdag fibrinnek mint humán autológ preparátumnak a használata elősegítheti a parodontalis defektusok sikeres kezelését. Orv Hetil. 2022; 163(12): 484–490. Summary. Autologous platelet concentrates are being used in more and more areas of medicine. Application of platelet-rich fibrin is the most topical among these therapeutic options. As main advantages, it can be prepared without the addition of anticoagulants, requires only one centrifugation and can be used in various forms. A new generation of platelet-rich fibrin may open up further opportunities, including those in periodontal wound healing. The aim of this case series is to provide a short-term clinical evaluation of the healing of periodontal intrabony defects after treatment with an autologous platelet-rich fibrin product (advanced platelet-rich fibrin). The presented cases were evaluated preoperatively and 6 months after surgery by recording the following periodontal parameters: probing depth and clinical attachment level. After full-thickness flap preparation, intrabony defect curettage, scaling and root planing were performed, followed by the application of preoperatively prepared platelet-rich fibrin and wound closure. Six months after surgery, pocket depth reductions and clinical attachment level gains were observed. In our presented cases, the platelet-rich fibrin application showed positive clinical results regarding periodontal wound healing and may facilitate the successful treatment of periodontal defects. Orv Hetil. 2022; 163(12): 484–490.

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Sharma, Disha, Shobha Mohindroo, and Ramesh K. Azad. "Efficacy of platelet rich fibrin in myringoplasty." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 3 (April 26, 2018): 677. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20181670.

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<p class="abstract"><strong>Background:</strong> Myringoplasty involves repair of tympanic membrane perforation with an autologous graft.The aim was to compare between myringoplasty with PRF and myringoplasty without fibrin.</p><p class="abstract"><strong>Methods:</strong> This study was conducted from July 2016 to June 2017,100 patients were taken. In 50 patients platelet rich fibrin was placed over graft and external auditory canal during myringoplasty and 50 without PRF. </p><p class="abstract"><strong>Results:</strong> It was seen in the study that PRF improves overall success rate of myringoplasty study and there was significant improvement in ABG at 500 hz, 1000 hz, 2000 hz frequencies.</p><p class="abstract"><strong>Conclusions:</strong> The higher success rate of myringoplasty with PRF was seen as compared to myringoplasty without fibrin. There were no noticeable side effects.</p>

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Sudrajat, Nandang, Bimanda Rizki Nurhidayat, Oggy Satriya Putra, Rozalina Loebis, and Ismi Zuhria. "Relation between Blood Parameters and Platelet-Rich Fibrin Membrane Size for Ocular Graft." NeuroQuantology 20, no. 4 (May 18, 2022): 454–59. http://dx.doi.org/10.14704/nq.2022.20.4.nq22258.

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Purpose: To investigate the relationship between blood parameters and platelet-rich fibrin (PRF) membrane size for ocular graft. Methods: Total of 12 New Zealand white rabbits, 6.5 ml of blood samples was taken for each rabbit, including 5 ml for platelet-rich fibrin membrane production using L-PRF protocol (centrifugation at 2700 rpm for 12 minutes) 1.5 ml for evaluation of blood parameters. Measurement of blood parameters consists of fibrinogen, haemoglobin, hematocrit, red blood cell (RBC), white blood cell (WBC) and platelet. Measurement of the platelet-rich fibrin membrane area was done using a calibrated photograph and ImageJ software. The Pearson correlation coefficient (r) was used to evaluate each scattergram statistically. Results: Linear regression analysis found a significant positive effect on the PRF membrane area on the fibrinogen (r = 0.802, p = 0.02), WBC (r = 0.625, p = 0.03) and platelet (r = 0.839, p = 0.001). However, there was no apparent correlation to haemoglobin (r = 0.514, p = 0.087), RBC (r = 0.548, p = 0.065) and hematocrit (r = 0.454, p = 0.138). Conclusions: The area of the PRF membrane has a positively significant relation to the fibrinogen, WBC and platelets. The data in this study can be used to estimate the size of the PRF membrane as an ocular graft.

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Mody, Dhawal, and Vrushali Lathiya. "Platelet Rich Fibrin in the Treatment of Localised Gingival Recession: A Case Report." International Journal of Research and Review 8, no. 5 (May 8, 2021): 24–29. http://dx.doi.org/10.52403/ijrr.20210505.

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Root recession presents a matter of aesthetic concern in every dental practice. Also it may illicit sensitivity and is more prone to caries than the covered root surfaces. Platelet- rich fibrin is a second generation platelet concentrate. It is basically autologous leukocyte and platelet-rich fibrin biomaterial. The use of PRF in combination with coronally advanced flap in the treatment of gingival recession has shown promising results and is gaining immense popularity among the dental practitioners. This case reports the use of PRF membrane in root coverage on the labial surface of maxillary canine. Keywords: Coronally advanced flap, platelet rich fibrin, gingival recession, growth factors.

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Caruana, Andrea, Daniele Savina, José Paulo Macedo, and Sandra Clara Soares. "From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery." European Journal of Dentistry 13, no. 02 (May 2019): 280–86. http://dx.doi.org/10.1055/s-0039-1696585.

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AbstractIn the past 20 years, the platelet concentrates have evolved from first-generation products, i.e., platelet-rich plasma (PRP) and plasma rich in growth factors to the second-generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). These autologous products with a higher leukocyte inclusion and flexible fibrin mesh act as a scaffold to increase cellular migration in the angiogenic, osteogenic, and antimicrobial potential of these biomaterials in tissue regeneration. In the second-generation platelet concentrates, the protocols are easier, cheaper, and faster with an entire physiological fibrin matrix, resulting in a tridimensional mesh, not as rigid as one of the first generations. This allows the slow release of molecules over a longer period of time and triggers the healing and regenerative process at the site of injury. The potential of A-PRF to mimic the physiology and immunology of wound healing is also due to the high concentration of growth factors released as follows: vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-β, and anti-inflammatory cytokines that stimulate tissue cicatrization, vessels formation, and bone cell proliferation and differentiation. Furthermore, the number of neutrophils and monocytes/macrophages is higher releasing important chemotactic molecules such as chemokine ligand-5 and eotaxin. Thus, L-PRF and A-PRF have been used, especially in implantology, periodontology, and maxillofacial surgery. Future clinical applications include tissue regeneration/grafts, ulcers/skin necrosis in the diabetic patient and others, plastic surgery, and even musculoskeletal lesions.

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MOHAMMED, Jiyar. "Efficacy of Platelet Rich Fibrin on Angiogenesis." Journal of Duhok University 23, no. 1 (September 14, 2020): 172–77. http://dx.doi.org/10.26682/csjuod.2020.23.1.18.

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In this experiment we used platelet-rich fibrin (L-PRF) with the protocol of its production, in this study we tried to investigate the angiogenetic efficacy of L-PRF on s soft tissue. Blood samples of 8 sheep were used to establish the protocol of the L-PRF formation to develop the work. The mucoperiosteal flaps were filled with autologous L-PRF in the mandible and maxillary jaws of the sheep. Samples taken from the surgical sites stained with haematoxylin and eosin for diagnosis of the sections, then immunohistological tests were confirmed on these sections. We noticed that after 14 days of membranes implantation there was no significant differences between their histological sections. While in histological section of 28 days, the sections with PRF has more angiogenic effect in soft tissue with much and more organized vessels in compare with control one.

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Vijayalakshmi, B., and S. Pradeep. "Role of platelet rich fibrin in dentistry." Research Journal of Pharmacy and Technology 9, no. 11 (2016): 2037. http://dx.doi.org/10.5958/0974-360x.2016.00416.9.

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Sharma, NareshKumar. "Platelet-rich fibrin: Emerging biomaterial in regeneration." National Journal of Maxillofacial Surgery 9, no. 1 (2018): 1. http://dx.doi.org/10.4103/njms.njms_40_18.

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Iv, Chenchev, Neichev D, Atanasov D, and Dobreva D. "Oroantral Communication Repair Using Platelet-Rich Fibrin." IOSR Journal of Dental and Medical Sciences 15, no. 10 (October 2016): 100–104. http://dx.doi.org/10.9790/0853-151003100104.

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Khalifa, Mohammed Hussein, Mena Zarif Helmy, Asser AbdElhamed Goda, and Kamal A. A. M. Hasanein. "Platelet-rich Fibrin for Chronic Wounds Management." Egyptian Journal of Hospital Medicine 85, no. 2 (October 1, 2021): 3878–82. http://dx.doi.org/10.21608/ejhm.2021.205096.

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Shetty, Mamatha, and Srikala Bhandary. "Applications of platelet rich fibrin in dentistry." Gulhane Medical Journal 64, no. 1 (March 7, 2022): 1–5. http://dx.doi.org/10.4274/gulhane.galenos.2021.1597.

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Kuiš, Davor, Ivan Matoš, Ivana Mišković, Filip Matija Vuković, and Jelena Prpić. "Platelet rich fibrin in periodontal plastic surgery." Medicina Fluminensis 54, no. 2 (June 1, 2018): 177–81. http://dx.doi.org/10.21860/medflum2018_198223.

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