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Journal articles on the topic 'Platelets count'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Hanson, SR, and SJ Slichter. "Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement." Blood 66, no. 5 (1985): 1105–9. http://dx.doi.org/10.1182/blood.v66.5.1105.1105.

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Abstract We have studied 16 normal subjects and 27 patients with stable, untreated thrombocytopenia secondary to bone marrow failure and platelet counts ranging from 12,000 to 70,000/microL. Autologous platelets were labeled with 51Cr for measurement of mean platelet life span in the normal subjects and in 20 patients. Labeled donor cells were used in the remaining subjects. Platelet survival, as determined with both autologous and homologous platelets, correlated directly with platelet count in the thrombocytopenic patients. Platelet life span was only modestly reduced in patients having coun

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2

Hanson, SR, and SJ Slichter. "Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement." Blood 66, no. 5 (1985): 1105–9. http://dx.doi.org/10.1182/blood.v66.5.1105.bloodjournal6651105.

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We have studied 16 normal subjects and 27 patients with stable, untreated thrombocytopenia secondary to bone marrow failure and platelet counts ranging from 12,000 to 70,000/microL. Autologous platelets were labeled with 51Cr for measurement of mean platelet life span in the normal subjects and in 20 patients. Labeled donor cells were used in the remaining subjects. Platelet survival, as determined with both autologous and homologous platelets, correlated directly with platelet count in the thrombocytopenic patients. Platelet life span was only modestly reduced in patients having counts in the

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3

Goodnough, Lawrence T., David J. Kuter, Jeffrey McCullough, et al. "Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin." Blood 98, no. 5 (2001): 1346–51. http://dx.doi.org/10.1182/blood.v98.5.1346.

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Many patients receiving dose-intensive chemotherapy acquire thrombocytopenia and need platelet transfusions. A study was conducted to determine whether platelets harvested from healthy donors treated with thrombopoietin could provide larger increases in platelet counts and thereby delay time to next platelet transfusion compared to routinely available platelets given to thrombocytopenic patients. Community platelet donors received either 1 or 3 μg/kg pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) or placebo and then donated platelets 10 to 15 days later.

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Octavira, Imanta Alifia, Agrijanti Agrijanti, Lalu Srigede, and Siti Zaetun. "Perbandingan Jumlah Trombosit pada Pasien COVID-19 dengan Kadar Glukosa yang Berbeda." Jurnal Kesehatan Andalas 11, no. 2 (2022): 95. http://dx.doi.org/10.25077/jka.v11i2.2000.

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Hyperglycemia has increased arachidonic acid thromboxane which is an effective ingredient in platelet activation. Thrombocytopenia in COVID-19 patients occurs through a variety of mechanisms, such as uncontrolled production of cytokines destroying bone marrow progenitor cells, direct inhibition of hematopoiesis viral infection of the bone marrow, increase in autoantibodies and immune complexes that cause platelet destruction, and lung injury that causes platelet aggregation and consumption of platelets so that platelets in the circulation are reduced. Objectives: To analyzed the ratio of plate

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Sallmon, Hannes, Boris Metze, Petra Koehne, et al. "Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus." Cardiology in the Young 30, no. 6 (2020): 769–73. http://dx.doi.org/10.1017/s1047951120000943.

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AbstractBackground:Thrombocytopenia is a risk factor for patent ductus arteriosus. Immature and mature platelets exhibit distinct haemostatic properties; however, whether platelet maturity plays a role in postnatal, ductus arteriosus closure is unknown.Methods:In this observational study, counts of immature and mature platelets (=total platelet count − immature platelet count) were assessed on days 1, 3, and 7 of life in very low birth weight infants (<1500 g birth weight). We performed echocardiographic screening for haemodynamically significant patent ductus arteriosus on day 7.Results:Co

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6

Tucker, Erik I., Ulla M. Marzec, Sawan Hurst, András Gruber, and Stephen R. Hanson. "Moderate Pharmacological Platelet Count Reduction Limits Thrombus Formation without Hemostatic Impairment in Primates." Blood 112, no. 11 (2008): 1033. http://dx.doi.org/10.1182/blood.v112.11.1033.1033.

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Abstract Despite the established contribution of platelets to thrombotic cardiovascular disorders, documented in part by the effectiveness of platelet function inhibitors and the increased risk of thrombosis associated with high normal and supranormal platelet counts, relationships between circulating platelet count and thrombotic events remain largely undefined. Since the initiation and propagation of arterial, platelet-dependent thrombus must depend upon platelet count, albeit in a manner that could be nonlinear, we hypothesized that reducing platelet count within the normal range would prod

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Prasetya, Hieronymus Rayi, Maria Irena Dentri, and Sistiyono Sistiyono. "Perbedaan Hitung Jumlah Trombosit Menggunakan Darah Vena dan Darah Kapiler." Journal of Health 3, no. 2 (2016): 81. http://dx.doi.org/10.30590/vol3-no2-p81-84.

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Background: Platelets play a role in hemostasis which is the body's mechanisms to prevent and stop the bleeding. Platelets participate in the effort to close the wound, so that the body does not experience a loss of blood and protected from foreign cells. Examination of the platelet count is very important in the diagnosis of diseases, one of which is the diagnosis of dengue hemorrhagic fever (DHF). Examination of blood counts, especially platelets in clinical laboratories causes blood samples in use are not always the venous blood but could use capillary blood. Capillary blood samples are use

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8

Hoffmann, Johannes J. M. L., Nicole M. A. van den Broek, and Joyce Curvers. "Reference Intervals of Reticulated Platelets and Other Platelet Parameters and Their Associations." Archives of Pathology & Laboratory Medicine 137, no. 11 (2013): 1635–40. http://dx.doi.org/10.5858/arpa.2012-0624-oa.

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Context.—Reticulated platelets are platelets recently released from the bone marrow, and they can serve as a noninvasive indicator of recent megakaryopoietic activity. Widespread clinical use has been hampered by laborious methods and lack of standardization. Recently, a fully automated method was released on the Abbott CELL-DYN Sapphire hematology analyzer. Objective.—To establish reference ranges for reticulated platelets. Secondary aims were to investigate associations between reticulated platelets and other platelet parameters like mean platelet volume, plateletcrit, and platelet distribut

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9

Shiwangi, Chhanwal, Joshi Jigyasu, Rajak Vijay, and Nishu. "Changes in Platelet Parameters in Conditions of Leucocytosis." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 981–83. https://doi.org/10.5281/zenodo.13620627.

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<strong>Background: </strong>Platelets are primarily concerned with haemostatic function but there are accumulating evidences to suggest their role in the pathophysiology of different clinical conditions that can be correlated with platelet parameters to some extent. This study was aimed to find out the relationship between WBC count in conditions of leucocytosis and platelet count and platelet parameters namely mean platelet volume, platelet distribution width and plateletcrit. <strong>Method: </strong>Complete blood count records of total 1000 cases were evaluated dividing the

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Speer, Oliver, Markus Schmugge, Imane Azzouzi, Margaret L. Rand, and Sabine Kroiss. "Apoptosis in Platelets from Pediatric Patients with Acute Immune Thrombocytopenic Purpura (ITP) Is Ameliorated by IV Ig." Blood 112, no. 11 (2008): 3417. http://dx.doi.org/10.1182/blood.v112.11.3417.3417.

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Abstract Interaction of auto-antibodies with platelet surface glycoproteins (GP) has been implicated in the accelerated clearance of platelets in ITP. It was recently shown, using a murine model, that the ITP induced by injection of anti-GPIIb is associated with apoptotic-like processes in platelets. These apoptotic-like processes in platelets were similar to those observed during apoptosis in nucleated cells: activation of caspase-3 (aCASP3), loss of mitochondrial inner transmembrane potential and externalisation of phosphatidylserine (PS). Administration of IVIg, that ameliorates the ITP in

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11

Roccaforte, Vincenzo, Massimo Daves, Adawiya Alfreijat, et al. "Spurious elevation of serum potassium concentration measured in samples with thrombocytosis." Diagnosis 3, no. 2 (2016): 71–74. http://dx.doi.org/10.1515/dx-2016-0008.

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AbstractSeveral factors that can lead to falsely elevated values of serum. Thrombocytosis is one of these factors, since breakage or activation of platelets during blood coagulation in vitro may lead to spurious release of potassium. The purpose of the study was to evaluate to which extent the platelet count may impact on potassium in both serum and plasma.The study population consisted of 42 subjects with platelets values comprised between 20 and 750×10Significant differences were found between potassium values in serum and in plasma. A significant correlation was also observed between serum

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12

Sokolova, N. A., M. I. Savina, and O. S. Shokhina. "EDTA‑dependent pseudothrombocytopenia in child (clinical case report)." Medical alphabet, no. 13 (June 29, 2021): 51–54. http://dx.doi.org/10.33667/2078-5631-2021-13-51-54.

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Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent pseudothrombocytopenia is usually prevented by other anticoagulants, such as sodium citrate. EDTA-dependent pseudothrombocytopenia has never been associated with hemorrhagic diathesis or platelet dysfunction. In this article, a 2,5-year-old boy with EDTA-dependent pseudothrombocytopenia is presented because of rare presentation. We r

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Mantha, Simon, and Yanyun Wu. "Safety of Central Venous Catheter Removal in the Setting of Thrombocytopenia and Peripheral Blood Stem Cell Collection." Blood 106, no. 11 (2005): 4182. http://dx.doi.org/10.1182/blood.v106.11.4182.4182.

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Abstract Thrombocytopenia is not uncommonly seen in patients undergoing peripheral blood stem cell collection. It is most likely secondary to the administration of chemotherapy and G-CSF, as well as the apheresis process itself. Peripheral blood stem cell collection causes a variable loss of platelets, which are collected along with the mononuclear cells. The ensuing thrombocytopenia can be at times severe, but the bleeding risk in this setting is unclear, as is the need to administer platelets prophylactically when the central catheter used for collection is removed. In this study we retrospe

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14

Gidron, Adi, and Jayesh Mehta. "Leukocyte and Platelet Counts Can Be Used To Guide Collection of Autologous Stem Cells after G-CSF Mobilization on the First Two Days of Leukapheresis but Not Beyond." Blood 106, no. 11 (2005): 5278. http://dx.doi.org/10.1182/blood.v106.11.5278.5278.

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Abstract We have shown recently that when healthy donors are treated with G-CSF to collect stem cells for allogeneic transplantation, the combination of a pre-apheresis leukocyte count of ≥25 x 109/L and a pre-apheresis platelet count of ≥100 x 109/L is associated with excellent mobilization as measured by an absolute peripheral blood CD34+ cell count (PBCD34) of ≥20/μL, and can be used to guide harvest timing (Tomblyn et al. Bone Marrow Transplantation advance online publication 01 August 2005; doi: 10.1038/sj.bmt.1705117). We wanted to see if this observation could be extended to patients re

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15

Baldini, Simone, Luigi Rigacci, Valentina Carrai, Renato Alterini, Rajmonda Fjerza, and Alberto Bosi. "PATIENTS WITH ≥ 20 X 109/L PLATELETS AT BASELINE MAY HAVE A PROMPT RESPONSE TO ROMIPLOSTIM DURING THE EARLY PHASE OF TREATMENT: AN ITALIAN SINGLE-INSTITUTION EXPERIENCE." Mediterranean Journal of Hematology and Infectious Diseases 4, no. 1 (2012): e2012044. http://dx.doi.org/10.4084/mjhid.2012.044.

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Patients with chronic immune thrombocytopenia treated with romiplostim may benefit from a higher starting dose when a rapid increase in count is needed, but it could be avoided in those with a prompt response to the standard dosage. We hypothesized that a platelet count ≥ 20 x 109/l at baseline could distinguish subjects with such response from those with a delayed one during the early phase of treatment. Our work is a retrospective and single-institution analysis comparing the median platelet count, the median weekly dosage of romiplostim and the median number of weekly platelet counts < 5

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16

Greve, Frederik, Ina Aulbach, Olivia Mair, Peter Biberthaler, and Marc Hanschen. "The Clinical Impact of Platelets on Post-Injury Serum Creatinine Concentration in Multiple Trauma Patients: A Retrospective Cohort Study." Medicina 58, no. 7 (2022): 901. http://dx.doi.org/10.3390/medicina58070901.

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Background and objective: Platelets contribute to the immunological response after multiple trauma. To determine the clinical impact, this study analyzes the association between platelets and creatinine concentration as an indicator of kidney function in polytraumatized patients. Methods: We investigated all patients presenting an Injury Severity Score (ISS) ≥16 for a 2-year period at our trauma center. Platelet counts and creatinine concentrations were analyzed, and correlation analysis was performed within 10 days after multiple trauma. Results: 83 patients with a median ISS of 22 were inclu

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17

Sultana, Razia, SM Fazlul Karim, Farhana Atia, Shahnila Ferdousi, and Selina Ahmed. "Platelet Count In Preeclampsia." Journal of Dhaka National Medical College & Hospital 18, no. 2 (2013): 24–26. http://dx.doi.org/10.3329/jdnmch.v18i2.16018.

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Preeclampsia is one of the most leading causes of maternal mortality in developing countries like Bangladesh. Several studies have demonstrated the relationship between platelets count and preeclampsia. The aim of the study was to assess the association of platelets count with preeclampsia. A case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in third trimester of pregnancy attending in Obstetrics & Gynaecology Department of Dhaka Medical Hospital were selected as study subjects.

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18

Vinholt, Pernille J. "The role of platelets in bleeding in patients with thrombocytopenia and hematological disease." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 12 (2019): 1808–17. http://dx.doi.org/10.1515/cclm-2019-0380.

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Abstract This review evaluates the role of platelets in bleeding risk among patients with hematological disease and thrombocytopenia. Platelets are pivotal in primary hemostasis, and possess non-hemostatic properties involved in angiogenesis, tissue repair, inflammation and metastatis. Also, platelets safeguard vascular integrity in inflamed vessels. Overall, bleeding risk depends on the underlying disease, and patients with cancer and platelet count <6–10 × 109/L have a markedly increased bleeding risk, while the platelet count does not correlate with bleeding risk at higher platelet count

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Ajay, Kumar, Kumar Binay, Kanaujia Binita, and Raza Sahab. "A Retrospective Investigation to Study the Relationship between White Blood Cell Count (WBC), Which is Known Inflammatory Marker and Platelet Count (PLT) and its Parameters." International Journal of Toxicological and Pharmacological Research 13, no. 2 (2023): 76–82. https://doi.org/10.5281/zenodo.11280384.

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<strong>Aim: </strong>The aim of this study was to investigate the relationship between white blood cell count (WBC), which is known inflammatory marker and platelet count (PLT) and its parameters including mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet- large cell ratio (P-LCR) in all clinical setting of leukocytosis in children. <strong>Methods: </strong>We performed a retrospective study on the children (2-18 years of age) coming to our laboratory Netaji Subhas Medical College & Hospital, Bihta, Patna, Bihar for the period o

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20

Kroiss, Sabine, Oliver Speer, Jeannine Winkler, Alexandra Förderer, and Markus Schmugge. "IVIG Ameliorates Thrombin Activation of Platelets and Endogenous Thrombin Potential In Pediatric Patients with ITP." Blood 116, no. 21 (2010): 3706. http://dx.doi.org/10.1182/blood.v116.21.3706.3706.

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Abstract Abstract 3706 Immune thrombocytopenia (ITP) is a common hematological disorder in children that can lead to severe bleeding symptoms. Previous studies in ITP patients have found autoantibodies that bind to glycoprotein (GP) complex GPIIb/IIIa or GPIb/IX (Kiefel V et al. Br J Hematol 1991) and thus can alter platelet function (Olsson A et al. Thromb Res 2002; Nissner H et al. Blood 1986). Although platelet function has been studied in chronic ITP and in pediatric ITP (Panzer S et al. Europ J Haemat 2007; Semple et al. Blood 1996), so far platelet function was not studied in response to

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Asad Adam Abbas and Soad Fadal Allah Ali. "Pre-donation assessment of platelets count among Sudanese blood donors attending central blood bank, Gezira state, Wad Madani, Sudan, 2023." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 1379–85. http://dx.doi.org/10.30574/wjarr.2023.18.2.0925.

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Objective: To estimate platelets count among Sudanese platelets donors attending the central Blood Bank in Wad Madani. Material and Methods: Venous blood samples were taken from 200 apparently healthy males donors and the platelets count were measured using an automated cell counter (Sysmex KN21). Results: The study revealed that significant number of donors with abnormal Platelets count specially thrombocytopenia, reactive thrombocytosis occurred in 4 donors with platelet count more than 450 × 10 9 /L. Conclusion: Complete blood count is very important using automated blood cell counter and m

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Anil, Kumar, Bharti Pranav, and Mishra Asim. "A Prospective Study of Platelet Indices and Their Interpretation in Thrombocytopenia at a Tertiary Care Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 1334–39. https://doi.org/10.5281/zenodo.11288767.

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<strong>Background:</strong> Thrombocytopenia is defined as a platelet count of <150 × 10<sup>9</sup>/L, although patients with a platelet count >50 × 10<sup>9</sup>/L are usually asymptomatic. Severe spontaneous bleeding is rare in thrombocytopenia. It is more common when the platelet count is <20 × 10<sup>9</sup>/L, and particularly when <10 × 10<sup>9</sup>/L. <strong>Aims and Objectives:</strong> The present study was conducted to evaluate platelet indices and their interpretation in thrombocytopenia in a tertiary care hospital. <stro

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Chu, Ying-Hsia, William Nicholas Rose, William Nawrot, and Thomas J. Raife. "Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology." Journal of International Medical Research 49, no. 5 (2021): 030006052110167. http://dx.doi.org/10.1177/03000605211016748.

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Background At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available. Study design and methods Seven patients were analyzed. Platelet counts were available from 57 single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model was used and significance was determined using a likelihood ratio test. Results When analyzed as the only fixed effect in the model, the use of pooled versus single-donor units and time from transfusio

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Saini, Vandana, Vijaya Vallepu, and Mamta Gupta. "Platelet Counts and Indices Are Altered in Pre-Eclampsia." Annals of Pathology and Laboratory Medicine 7, no. 7 (2020): A361–365. http://dx.doi.org/10.21276/apalm.2830.

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BACKGROUND: Endothelial damage and activation of platelets leading to their increased consumption and increase in production of young platelets by bone marrow is the most common pathophysiology of pre-eclampsia. Thus, fall in platelet count and altered platelet indices may have diagnostic as well as prognostic value in pre-eclampsia. AIM: To evaluate platelet count and platelet indices between pre-eclamptic and normotensive women and to assess their association with severity of pre-eclampsia. METHODS: Platelet counts and indices were estimated in 30 normotensive and 30 PE women at 20-24

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Aranda, Eduardo, Myriam Pizarro, Jaime Pereira, and Diego Mezzano. "Accumulation of 5-Hydroxytryptamine by Aging Platelets: Studies in a Model of Suppressed Thrombopoiesis in Dogs." Thrombosis and Haemostasis 71, no. 04 (1994): 488–92. http://dx.doi.org/10.1055/s-0038-1642465.

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SummaryThrombocytopenia was induced in healthy, male mongrel dogs by intramuscular injection of a single dose of estradiol valerate (1 mg/kg). A steady, almost linear decay of the blood platelet count starting about day 6 post-estradiol and attaining a mean value of 14 × 103 platelets/pi one week later was observed. Thrombocytopenia is explained mainly by suppression- of thrombocytopoiesis, as established by two independent ways: 1. Megakaryocytes in the bone marrow were markedly reduced. 2. Kinetic studies with 11‘In labeled autologous platelets revealed a nearly linear decay of the radioacti

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H. Abboud, Sameer, Majid K. Abbas, Saadia S. MehdyZaini, and Mohamed T. Naqi. "The potential effects of short course of Statins on some platelets parameters in rats." AL-QADISIYAH MEDICAL JOURNAL 10, no. 18 (2017): 94–97. http://dx.doi.org/10.28922/qmj.2014.10.18.94-97.

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Background : Platelets play an important role in the process of homeostasis, specifically in atherosclerosis formation when low molecular weight lipoprotein deposit in the wall of blood vessels and plaques formation ,this associated with many inflammatory response one of them is Platelet activation subsequent to the adhesion of platelets to the vascular wall results in the release of mediators that promote platelet aggregation. Aim : Statins as most drugs used for treatment hyperlipidemia have multiple effects including anti inflammatory effects , stabilization of plugs and inhibits platelets

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Peck-Radosavljevic, Markus, Martina Wichlas, Johannes Zacherl, et al. "Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production." Blood 95, no. 3 (2000): 795–801. http://dx.doi.org/10.1182/blood.v95.3.795.003k25_795_801.

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Thrombopoietin (TPO) deficiency has been proposed as an important etiologic factor for thrombocytopenia in advanced-stage liver disease. To clarify the contributions of platelet production, platelet consumption, coagulation activation, and splenic sequestration to thrombocytopenia in liver disease, we studied TPO serum levels and markers of platelet production, platelet activation, and coagulation activation before and 14 days after orthotopic liver transplantation (OLT) in 18 patients with advanced liver cirrhosis. Thrombocytopenia before transplantation occurred with low-normal serum levels

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Zubkova, Z. V., and I. A. Novikova. "Morphofunctional properties of platelets in patients with rheumatoid arthritis." Health and Ecology Issues, no. 2 (June 30, 2021): 55–61. http://dx.doi.org/10.51523/2708-6011.2021-18-2-8.

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Objective: to assess the morphofunctional properties of platelets in patients with rheumatoid arthritis (RA) in combination with other clinical and laboratory characteristics of the disease.Materials and methods. The parameters of platelet hemostasis were studied in 51 RA patients with varying degrees of disease activity according to the DAS28 index.Results. It has been found that the count of platelets in the peripheral blood and their aggregation properties depend on the indicators of the activity of the inﬂammatory process (degree of activity, ESR, level of C-reactive protein). Platelet ind

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Sokolic, Robert A., Thomas Markello, Marcy Krumwiede, et al. "Reduced Number of Dense Bodies and Reduced Serotonin Content in Platelets of Patients with Wiskott-Aldrich Syndrome." Blood 114, no. 22 (2009): 1321. http://dx.doi.org/10.1182/blood.v114.22.1321.1321.

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Abstract Abstract 1321 Poster Board I-343 Wiskott-Aldrich syndrome is characterized by immune deficiency and thrombocytopenia. There is also a qualitative platelet defect in Wiskott-Aldrich syndrome, typically presenting on aggregometry as a failure of the second wave of aggregation. The pathophysiology of this defect has not been studied in detail. To investigate this phenomenon, we enumerated dense bodies and measured serotonin content in the platelets of 7 patients with Wiskott-Aldrich syndrome. Patients ranged in age from 14 to 45 years old. Five of 7 patients had had splenectomy. In these

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Frelinger, Andrew L., Anja J. Gerrits, Michelle A. Berny-Lang, et al. "Association Of Platelet Function Markers, Independent Of Platelet Count, With Bleeding Score In Patients With Immune Thrombocytopenia." Blood 122, no. 21 (2013): 3534. http://dx.doi.org/10.1182/blood.v122.21.3534.3534.

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Abstract Background Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. Aim To determine if differences in platelet function in ITP patients with similarly low platelet counts partly account for the variation in bleeding tendency. Methods The relationship between bleeding scores and platelet function markers was investigated in a single center cross-sectional study of pediatric patients with ITP. Following informed consent, blood was collected from ITP patients and bleeding was graded using the Buchanan and Adix Score (J Pediatr 2002) at

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Spahr, Joseph E., Neeraj Agarwal, and George M. Rodgers. "Treatment of Immune-Mediated Thrombocytopenia Purpura with Concurrent IVIg and Platelet Transfusion: A Retrospective Review of 40 Patients." Blood 108, no. 11 (2006): 3972. http://dx.doi.org/10.1182/blood.v108.11.3972.3972.

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Abstract Introduction: In January 2000, two patients with severe Immune-Mediated Thrombocytopenia (ITP) at our institution were successfully treated with prolonged infusions of IVIg and platelets. The dose of IVIg was 1 g/kg given by continuous infusion over 24 hours with concurrent platelets (1 pheresis unit every 8 hours). Based on these preliminary results, we evaluated this protocol in a larger series of 40 ITP patients. Methods: We performed an IRB-approved retrospective review of adult hospitalized patients with ITP treated with this regimen from January 2000 - December 2005. Patients wi

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Ramírez-López, Andrés, María Teresa Álvarez Román, Elena Monzón Manzano, et al. "The Importance of Platelet Glycoside Residues in the Haemostasis of Patients with Immune Thrombocytopaenia." Journal of Clinical Medicine 10, no. 8 (2021): 1661. http://dx.doi.org/10.3390/jcm10081661.

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Loss of sialic acid from the carbohydrate side chains of platelet glycoproteins can affect platelet clearance, a proposed mechanism involved in the etiopathogenesis of immune thrombocytopaenia (ITP). We aimed to assess whether changes in platelet glycosylation in patients with ITP affected platelet counts, function, and apoptosis. This observational, prospective, and transversal study included 82 patients with chronic primary ITP and 115 healthy controls. We measured platelet activation markers and assayed platelet glycosylation and caspase activity, analysing samples using flow cytometry. Pla

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Pande, Priyanka, SreeNavya Inupala, Sowmya Jagana, Md Rasel Uzzaman, and Mulumebet Worku. "PSIV-28 Evaluation of Possible Interactions Between Platelets and Neutrophil in Cow Blood." Journal of Animal Science 101, Supplement_3 (2023): 358–59. http://dx.doi.org/10.1093/jas/skad281.424.

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Abstract Neutrophils have a central role in the inflammatory response and fight infection. Platelets are essential for hemostasis and thrombosis and fighting vascular damage. Studies in man show that the interaction between these cells can modulate their function. We aimed to assess the effect of possible relationships between the platelet count in whole blood on neutrophil activation. Blood samples (50 mL) from five clinically healthy Holstein Friesian cows at the NC A&T Dairy research unit were collected. Differential white blood cell counts were conducted using a VetScan (Zoetis). Neutr

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Moffat, Karen A., Menaka Pai, Yang Liu, et al. "An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts." Thrombosis and Haemostasis 100, no. 07 (2008): 01–12. http://dx.doi.org/10.1160/th08-03-0183.

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SummaryLight transmission platelet aggregation tests are important for diagnosing platelet function defects. However, uncertainties exist about the best procedures to determine aggregation reference intervals. We investigated methods for determining reference intervals for light transmission aggregation tests, using the % maximal aggregation values for prospectively collected data on healthy control samples. Reference intervals for samples tested at 250 x 109 platelets/l were determined by mean ± 2 standard deviations and non-parametric analyses. To establish reference intervals for tests on t

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Fawzi, Tania Meysavira, Lusiana Batubara, Asih Budiastuti, and Taufik Eko Nugroho. "MELATONIN CAN NOT SIGNIFICANTLY INCREASE PLATELET COUNT." DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) 10, no. 3 (2021): 166–71. http://dx.doi.org/10.14710/dmj.v10i3.29492.

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Background: Burn injury defines as skin or tissue damage caused by heat, radioactivity, electricity, or chemicals. Burn injury have an impact on physiological homeostasis. Burn injury will cause an increase in free radicals, it can also cause changes in the platelet count. Melatonin has been proposed as burn supportive therapy because it acts as an antioxidant that can eliminate free radicals. Melatonin can increase the number of the platelets through the mechanism of increasing megakaryocyte fragmentation and modulating the cytokines involved in platelet production. Aim: Proving the effects o

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Budde, U., RE Scharf, P. Franke, K. Hartmann-Budde, J. Dent, and ZM Ruggeri. "Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma." Blood 82, no. 6 (1993): 1749–57. http://dx.doi.org/10.1182/blood.v82.6.1749.1749.

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Abstract Twelve of 19 patients with myeloproliferative disorders showed a decrease of absence of the largest multimers of plasma von Willebrand factor (vWF) that correlated with elevated platelet counts but not with leukocyte counts. This suggested that platelets, rather than leukocytes, may be associated with the pathogenesis of the acquired vWF abnormality seen in these patients. To examine the hypothesis further, we studied 12 patients with reactive thrombocytosis after splenectomy. Increased platelet count (> 5 x 10(11)/L) after splenectomy was associated with vWF abnormalities indistin

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Budde, U., RE Scharf, P. Franke, K. Hartmann-Budde, J. Dent, and ZM Ruggeri. "Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma." Blood 82, no. 6 (1993): 1749–57. http://dx.doi.org/10.1182/blood.v82.6.1749.bloodjournal8261749.

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Twelve of 19 patients with myeloproliferative disorders showed a decrease of absence of the largest multimers of plasma von Willebrand factor (vWF) that correlated with elevated platelet counts but not with leukocyte counts. This suggested that platelets, rather than leukocytes, may be associated with the pathogenesis of the acquired vWF abnormality seen in these patients. To examine the hypothesis further, we studied 12 patients with reactive thrombocytosis after splenectomy. Increased platelet count (> 5 x 10(11)/L) after splenectomy was associated with vWF abnormalities indistinguishable

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Nührenberg, Thomas, Michael Amann, Marco Cederqvist, et al. "Impact of reticulated platelets on antiplatelet response to thienopyridines is independent of platelet turnover." Thrombosis and Haemostasis 116, no. 11 (2016): 941–48. http://dx.doi.org/10.1160/th16-03-0191.

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SummaryReticulated platelets are associated with impaired antiplatelet response to thienopyridines. It is uncertain whether this interaction is caused by a decreased drug exposure due to high platelet turnover reflected by elevated levels of reticulated platelets or by intrinsic properties of reticulated platelets. This study sought to investigate if the impact of reticulated platelets on early antiplatelet response to thienopyridines is mainly caused by platelet turnover as previously suggested. Elective patients undergoing coronary intervention were randomised to loading with clopidogrel 600

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Oshinowo, Oluwamayokun T., Renee Copeland, Christina Caruso, et al. "Increased Platelet Force Is Associated with Decreased Bleeding Severity in Pediatric Immune Thrombocytopenia." Blood 134, Supplement_1 (2019): 1096. http://dx.doi.org/10.1182/blood-2019-129573.

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Background: Immune Thrombocytopenia Purpura (ITP) can result in severely low platelet counts and while most of the 4,000 new cases of pediatric ITP diagnosed each year self-resolve, 10% of these patients have major bleeding episodes. The platelet count remains the mainstay method for predicting hemorrhage and unfortunately has only proven to be loosely correlated to bleeding severity. Consequently, there currently exists no biomarker that accurately and reliably predicts which patients need immediate medical treatment, all of which have side effects, and which patients only require monitoring.

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Strom, Ted S., Jim Y. Wan, Haiming Du, and Carl W. Jackson. "Rapid, Exponential Extra-Splenic Platelet Consumption in WASP Deficient Mice." Blood 106, no. 11 (2005): 2174. http://dx.doi.org/10.1182/blood.v106.11.2174.2174.

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Abstract The thrombocytopenia seen in patients with the Wiskott-Aldrich Syndrome (WAS) is thought to be due primarily to rapid platelet consumption, and is markedly improved by splenectomy. While a murine model of WAS shows only mild thrombocytopenia, we have previously demonstrated rapid platelet turnover in this model; that splenectomy improves the platelet count in WASP-(C57Bl/6J) mice; and that the latter mice do not achieve the same platelet count found in splenectomized WT mice. Here we show that CMFDA-labeled WASP- platelets are consumed rapidly and exponentially in WT recipients, with

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Asad, Adam Abbas, and Fadal Allah Ali Soad. "Pre-donation assessment of platelets count among Sudanese blood donors attending central blood bank, Gezira state, Wad Madani, Sudan, 2023." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 1379–85. https://doi.org/10.5281/zenodo.8414515.

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<strong>Objective:</strong> To estimate platelets count among Sudanese platelets donors attending the central Blood Bank in Wad Madani. <strong>Material and Methods:</strong> Venous blood samples were taken from 200 apparently healthy males donors and the platelets count were measured using an automated cell counter (Sysmex KN21). <strong>Results:</strong> The study revealed that significant number of donors with abnormal Platelets count specially thrombocytopenia, reactive thrombocytosis occurred in 4 donors with platelet count more than 450 × 10 <sup>9</sup> /L

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Abrams-Ogg, Anthony C. G., Stephen A. Kruth, Ronald F. Carter, Victor E. Valli, Suzanne Kamel-Reid, and Ian D. Dubé. "Preparation and transfusion of canine platelet concentrates." American Journal of Veterinary Research 54, no. 4 (1993): 635–42. http://dx.doi.org/10.2460/ajvr.1993.54.04.635.

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Summary A protocol was developed for preparation of platelet concentrates (pc) to support thrombocytopenic dogs. Four clinically normal dogs with platelet counts that ranged from 200 to 330 × 109 platelets/L were used as donors. One unit (450 ml) of blood was collected by venipuncture into a double blood bag. Whole blood (wb) was centrifuged for 4 minutes at 1,000 × g (braking time = 2 minutes, 30 seconds) to prepare platelet-rich plasma (prp). The prp was expressed into the satellite bag and was centrifuged for 10 minutes at 2,000 × g (braking time = 2 minutes, 36 seconds). The platelet-poor

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Żmigrodzka, M., M. Guzera, and A. Winnicka. "Flow cytometric assessment of activation of peripheral blood platelets in dogs with normal platelet count and asymptomatic thrombocytopenia." Polish Journal of Veterinary Sciences 19, no. 2 (2016): 407–14. http://dx.doi.org/10.1515/pjvs-2016-0051.

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AbstractPlatelets play a crucial role in hemostasis. Their activation has not yet been evaluated in healthy dogs with a normal and low platelet count. The aim of this study was to determine the influence of activators on platelet activation in dogs with a normal platelet count and asymptomatic thrombocytopenia. 72 clinically healthy dogs were enrolled. Patients were allocated into three groups. Group 1 consisted of 30 dogs with a normal platelet count, group 2 included 22 dogs with a platelet count between 100 and 200×109/land group 3 consisted of 20 dogs with a platelet count lower than 100×1

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Ghorbani, Mohammad, Babak Mahmoudi, Zahra Khoshnegah, et al. "Can a Platelet Flag Prevent Misdiagnosis? A Report of Two Different Platelet Counts by Two Different Cell Counters for a Patient." Journal of Kerman University of Medical Sciences 31, no. 1 (2024): 51–54. http://dx.doi.org/10.34172/jkmu.2024.09.

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Background: As platelet count is one of the valuable laboratory tests for disease diagnosis, its errors, such as the upper discrimination for the platelet volume distribution (PU) flag, could cause problems and misdiagnosis. Blood cell histogram evaluation can come close to overcoming the limitations of the platelet counting test. Case Report: In this study, a 36-year-old thalassemia minor male presented with the symptoms of fever and myalgia. Petechiae and purpura were observed in the patient’s lower extremities in the physical examination. Nihon Kohden Celltac G and Sysmex XP-300 cell counte

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Poudyal, Bishesh Sharma, Binaya Sapkota, Gentle Sunder Shrestha, Sujan Thapalia, Bishal Gyawali, and Sampurna Tuladhar. "Safety and Efficacy of Azathioprine as a Second Line Therapy for Primary Immune Thrombocytopenic Purpura." Journal of Nepal Medical Association 55, no. 203 (2016): 16–21. http://dx.doi.org/10.31729/jnma.2832.

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Introduction: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily available and well tolerated medicine. This study was carried out to evaluate efficacy and safety of azathioprine as a second line medicine for primary ITP patients who were refractory to steroid therapy.Methods: The observational, pre-post study was conducted at Government of Nepal Civil Service Hospital, Kathmandu from January to October 201

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Gilreath, Jeffrey A., Mei Wei, Shilpa Paul, Charles J. Parker, David D. Stenehjem, and George M. Rodgers. "Dynamic dosing of romiplostim in patients with immune thrombocytopenia purpura: Two case reports." Journal of Oncology Pharmacy Practice 25, no. 3 (2018): 719–23. http://dx.doi.org/10.1177/1078155217752536.

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Romiplostim is a thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia purpura. When following FDA-approved romiplostim prescribing recommendations to withhold treatment for platelet counts above 400k/µL, some patients exhibit a precipitous decline in their platelet count potentially causing patient harm. We present two cases where stable platelet counts were achieved only through persistent weekly dosing of romiplostim despite platelet counts above 400k/µL on the day of administration. Therefore, continuous weekly dosing of romiplostim despite platelet count be

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Rahman, Mohammad Mizanur, Lutfunnahar Khan, and Debashish Saha. "Dose- and time-related platelet response with apheresis platelet concentrates and pooled platelets." Bangabandhu Sheikh Mujib Medical University Journal 10, no. 1 (2017): 44. http://dx.doi.org/10.3329/bsmmuj.v10i1.31667.

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<p>This present study was carried out to compare the post-transfusion platelet increment between the apheresis platelet concentrate (n=74) and pooled platelets (n=54). Pre- and post-transfusion platelet count of the recipient were carried out by automated hematology analyzer. In apheresis platelet concentrate group, the mean 24 hours post-transfusion platelet increment was 47 x 10<sup>9</sup>/L which was statistically significant (p&lt;0.001). On the other hand, in pooled platelets group, the mean 24 hours post–transfusions platelet count increment was 11.0 x 10<sup&gt

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Babiker, Nihad Elsadig, Hameida Alfadil Alradi Mohammed, and Maye M. Merghani. "Relation of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Sudanese Subjects at Khartoum state, 2022." Journal of Drug Delivery and Therapeutics 13, no. 2 (2023): 80–85. http://dx.doi.org/10.22270/jddt.v13i2.5948.

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No diseases are known to result from the lack of expression of ABO blood group antigens, but the susceptibility to a number of diseases has been linked with a person's ABO phenotype. A cross sectional study conducted at research laboratory of Gharb El-Niel College from May to August 2022, to estimate the relation of ABO blood group on fibrinogen levels and platelet count in apparently healthy Sudanese subjects. For the A positive blood group there was significant decreased in the fibrinogen level when compared with the B⁺, O⁺ and O⁻ blood group, and in significant differences with the AB⁺ and

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Shiney, M.D, Devasena Indla., Sridevi B.R., Padma Geetanjali M., and Paramjyothi Pitta. "Effect of Aging on Blood Components Red Blood Cells, White Blood Cells, and Platelets in the Individuals of 30 to 60 Years Age Group." International Journal of Current Pharmaceutical Review and Research 15, no. 12 (2023): 458–62. https://doi.org/10.5281/zenodo.11520700.

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Background: Aging is a progressive deteriorative change. It occurs during the adult period of life. It increasesvulnerability to challenges. With an increase in age, there is a decrease in the count of red blood cells. Accordingto different studies, the total count of white blood cells shows no correlation with age, and platelet countdecreases with age.Aims: The present study was carried out to find the significant changes in the count of Red Blood Cells, thecount of White Blood Cells, and the count of Platelets which are the blood components with advancing age bothin males and females of 30 -

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Abdon, Faris Mohamed Awad, Elias Teages Adgoy, Nahom Yacob Berhane, et al. "A descriptive cross-sectional study of Platelets count in apparently healthy Eritrean blood donors attending the National Blood Transfusion Center, Asmara, Eritrea." Chinese Journal of Medical Research 3, no. 1 (2020): 14–17. http://dx.doi.org/10.37515/cjmr.091x.3105.

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Background: Platelets are an important constituent of blood. Safety measures of blood transfusion are important for optimum health environment. To the knowledge of the researchers, there is no study that was conducted concerning Platelets count in apparently healthy Eritrean blood donors. Therefore, this study will help in establishing the reference ranges of Platelets count in them. Objectives: To measure the serum platelets levels and mean platelets volume in apparently healthy Eritrean blood donors attending the national blood bank of Eritrea. Study design: Descriptive crosssectional study.

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