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Dissertations / Theses on the topic 'Platelets; Thrombocytopenia'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Joutsi-Korhonen, Lotta. "Autoimmune thrombocytopenia : detection of platelet-associated IgG, reticulated platelets and platelet Fcg[gamma] receptor polymorphism in thrombocytopenic patients." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/joutsi-korhonen/.

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2

Desborough, Michael J. R. "Desmopressin for treatment of thrombocytopenia or platelet dysfunction." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:4de19720-328a-4d01-9153-02dec6202aff.

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The objective of the work presented in this thesis was to explore the role of potential alternatives to platelet transfusions and specifically to investigate whether desmopressin could be used for treatment of thrombocytopenia or platelet dysfunction. Patients with thrombocytopenia or platelet dysfunction are often treated with platelet transfusions to treat or prevent bleeding. However the evidence for the efficacy of platelet transfusion is limited and there is some evidence of harm. I have focused on thrombocytopenic patients with haematological malignancies or critically ill patients, who

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3

Lundin, Ann-Sofie. "QUALITY OF TACSI PLATELETS AND THEIR EFFECT ON THROMBOCYTOPENIA PATIENTS." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126714.

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<p> </p><p><strong>Conclusion:</strong>Medical treatment may have a role in platelet count after transfusion. Since the TACSI platelets passed the quality requirements, and the vast majority of patients platelet count increased after TACSI platelet transfusion, the TACSI platelets will replace the old method to produce platelets at the Uppsala University hospital.</p><p> </p><p> </p><p><strong>Methods:</strong> A new approach that pools 8 buffy coats (TACSI platelets) that were separated into 2 units instead of 4-6 buffy coats pooled to 1 unit was investigated in this study. After the platelet

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4

Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

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Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because

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5

Rose, Leburn. "A computer based model for the simulation of platelet dosage size and platelet dosage interval in patients with stable thrombocytopenia." Thesis, London South Bank University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288172.

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6

Allen, David L. "A study of the Human Platelet Antigen 1a (HPA-1a) antibody response in neonatal alloimmune thrombocytopenia (NAIT)." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:44a10539-de5d-44dc-9c51-5f43cf3c3a82.

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Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal alloantibodies against fetal platelet antigens inherited from the father and which are absent from maternal platelets. In Caucasians, antibodies against the Leu33 (HPA-1a) polymorphism of integrin β3 (part of the platelet αIIbβ3 complex) account for >70% of cases. Antenatal screening for these antibodies does not currently take place in the UK, partly because of the absence of sensitive, predictive tests. We hypothesized that the poor sensitivity and predictive abilities of current assays are due to the use of β3 in an inappropr

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7

Rabbolini, David John. "Genotyping and experimental modelling of inherited thrombocytopenias." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18144.

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Inherited thrombocytopenia’s (IT) are characterised by low platelet counts and bleeding tendencies in affected individuals. Diagnosis of IT is important to guide treatment, inform prognosis and provide genetic counseling. Unfortunately, standard testing methods that interrogate platelet function and structure lack sensitivity, specificity and standardisation. This thesis developed and employed a next generation sequencing (NGS) platform for the diagnosis of IT and explored mechanisms underpinning IT through laboratory investigation of novel variants detected through this method. NGS was perfor

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8

Simões, Cátia Isabel da Cruz Pires Martins. "Trombocitopénia imuno-mediada na clínica de animais de companhia." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2008. http://hdl.handle.net/10400.5/1493.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Na clínica veterinária onde decorreu o estágio, a trombocitopénia é um sinal laboratorial encontrado com alguma frequência em cães e gatos apresentados para consulta veterinária devido a alguma alteração do estado hígido. A trombocitopénia pode ser secundária a diversos mecanismos, embora nesta dissertação se realcem os fenómenos de diminuição da contagem de plaquetas devidos a destruição imuno-mediada. Esta última caracteriza-se pela redução da contagem de plaquetas por unidade de volume de sangue acompanhada pela redução do v

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9

Simões, Cátia Isabel da Cruz Pires Martins. "Trombocitopénia imuno-mediada na clínica de animais de companhia." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2009. http://hdl.handle.net/10400.5/931.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Na clínica veterinária onde decorreu o estágio, a trombocitopénia é um sinal laboratorial encontrado com alguma frequência em cães e gatos apresentados para consulta veterinária devido a alguma alteração do estado hígido. A trombocitopénia pode ser secundária a diversos mecanismos, embora nesta dissertação se realcem os fenómenos de diminuição da contagem de plaquetas devidos a destruição imuno-mediada. Esta última caracteriza-se pela redução da contagem de plaquetas por unidade de volume de sangue acompanhada pela redução do volume

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10

Bennett, Cavan. "Cytokine receptor-like factor 3 (CRLF3) : a novel regulator of platelet biogenesis and potential drug target for thrombocythaemia." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277068.

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Thrombocythaemia is defined as a circulating platelet count above 450x10$^9$/L in humans. The major cause of thrombocythaemia is reactive $(secondary)$ thrombocythaemia which occurs secondary to many conditions such as infection, cancer and inflammation. However, acquired clonal mutations in mainly Janus Kinas 2 $(JAK2)$, CALR and MPL cause essential thrombocythaemia $(ET)$. ET is a rare disease that leads to an increased risk of cardiovascular thrombotic events. Current treatment of ET uses combination of low dose aspirin to decrease platelet function and cytoreductive agents to decrease thro

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11

Caboz, Mariana. "Clínica de animais de companhia." Master's thesis, Universidade de Évora, 2013. http://hdl.handle.net/10174/18390.

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estágio na área da Clínica de Animais de Companhia, assim como os casos acompanhados, e, ainda, uma breve monografia relativa ao tema “Trombocitopenia imunomediada”. Os canídeos foram a espécie mais representativa durante o período de estágio (58%) e a área com maior valor representativo foi a Patologia Médica (71,8%). A trombocitopenia imunomediada (TIM) é a manifestação de um distúrbio de hipersensibilidade, na qual anticorpos são direcionados contra as plaquetas levando à sua fagocitose e destruição pelos macrófagos. A sua prevalência pode chegar até 1% dos animais hospitalizados, sendo mai

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12

Oliveira, Samantha Carlos de. "Trombocitopenia induzida por heparina: aspectos clínicos e laboratoriais." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-04112008-155406/.

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A trombocitopenia induzida por heparina (TIH) é uma síndrome imunohematológica mediada por um anticorpo que causa ativação plaquetária na presença de heparina, induz à agregação plaquetária e pode estar associada a graves e paradoxais complicações trombóticas e morte. A freqüência de TIH nos pacientes que recebem heparina por mais de cinco dias é de 1% a 5%, e está relacionada a vários fatores. Este é um estudo pioneiro no Brasil, que objetivou avaliar aqui a freqüência de TIH nos pacientes em uso de heparina, a relação ao gênero, ao tipo de heparina e a associação do genótipo da FcRIIa de rec

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13

Watts, Timothy Lloyd. "The role of impaired megakaryocytopoiesis in thrombocytopenia in preterm babies." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270477.

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14

Wenger, Martin. "Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura /." [S.l : s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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15

Bouwmans, Eva Lamberta Antonia. "Human platelet antigen-1a presentation and antibody generation." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610311.

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16

Hickman, DaShawn Antwane. "Platelet-inspired Nanomedicine for the Hemostatic Management of Bleeding Complications in Thrombocytopenia and Trauma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1537017099431262.

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17

Crossley, Alison Rachel. "Immunological parameters in immune thrombocytopenic purpura and the effects of alpha interferon therapy." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308323.

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18

Donada, Alessandro. "Physiopathological mechanisms of two congenical platelet disorders : filaminopathy-A and ANKRD26-related - Thrombocytopenia 5THC2." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/DONADA_Alessandro_2_complete_2018.zip.

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Les thrombopénies héréditaires sont une classe de maladies hématologiques congénitaux affectant principalement la lignée mégacaryocytaire. Elle s’accompagnant d'une diminution du nombre de plaquettes. Près de 50 gènes différents ont été associés à des thrombopénies héréditaires, et d'énormes différences existent entre chaque maladie, en ce qui concerne la manifestation clinique et la pathobiologie. Mes recherches ont porté sur deux thrombopénies héréditaires différentes: Filaminopathie A et THC2. La première maladie est un syndrome X-linked, associé à des mutations dans le gène FLNA (Filamine

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19

Aghabeigi, N. "Identification and characterisation of anti-platelet antibodies in ITP patients." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5265.

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20

Stegner, David [Verfasser], and Bernhard [Akademischer Betreuer] Nieswandt. "Novel Aspects of Platelet Signaling and of the Pathogenesis of Immune Thrombocytopenia / David Stegner ; Betreuer: Bernhard Nieswandt." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1160876819/34.

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21

Barbosa, Alzira Maria de Castro. "Chronic immune thrombocytopenic purpura and infection Helicobacter pylori: platelet response to the bacteria elimination of treatment." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16378.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The Chronic Immune Thrombocytopenic Purpura (ITPc) is a condition caused by autoimmune response resulting awareness of platelets by self antiplatelet antibodies, causing lysis of platelets. Infection with H. pylori has been shown to likely factor for the development of PTIc, with possible platelet response relationship in PTIc after treatment of bacterial eradication. The objective was to evaluate possible effects of eradication of Helicobacter pylori in the number of platelets of patients with PTIC patients at the University Hos

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22

FALESCHINI, MICHELA. "DEVELOPMENT OF FUNCTIONAL ASSAYS TO DETERMINE THE PATHOGENIC VARIANTS OBTAINED BY NEXT GENERATION SEQUENCING IN INHERITED THROMBOCYTOPENIAS." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908004.

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Inherited thrombocytopenias (IT) are a heterogeneous group of diseases characterized by platelet count lower than 150x109/L. They are clinically and genetically heterogeneous diseases, with mutations in at least 30 causative. However, these genes account for approximately 50% of the IT patients, suggesting that novel forms are still to be characterized. For this reason, in collaboration with Medical Genetic Unit of Policlinico Sant’Orsola Malpighi in Bologna and the department of General Medicine 3 , IRCCS San Matteo in Pavia, our laboratory is applying the Next Generation Sequencing (NGS) tec

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23

Kimmerle, Sabine. "Rapid determination of Anti-Heparin/Platelet factor 4 antibody titers in the diagnosis of Heparin-induced Thrombocytopenia$cSabine Kimmerle." Bern : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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24

Souza, Evandro de Oliveira. "Avaliação funcional das plaquetas em pacientes com cirrose e sua relação com o risco de sangramento após ligadura elástica de varizes esofagianas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-16112017-081301/.

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Introdução: O sangramento por queda de escara é uma complicação potencialmente letal da ligadura elástica (LE) de varizes de esôfago. Os fatores relacionados a esse evento são pouco explorados na literatura, porém a coagulopatia, principalmente a plaquetopenia, do paciente com cirrose poderia estar implicada. O número e a função plaquetária têm particular relevância na manutenção da hemostasia, uma vez que a geração de trombina depende fortemente desses parâmetros. Entretanto, dados demonstram a preservação da função plaquetária como consequência de mecanismos compensatórios representados, pri

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25

Estcourt, Lise Jane. "Risk factors for haemorrhage in patients with haematological malignancies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4efbd9b1-62e5-4536-a5ee-df5eea4620d0.

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Haematological malignancies and their treatment lead to prolonged periods of severe thrombocytopenia (platelet count ≤ 50 x 10<sup>9</sup>/l). Despite the use of prophylactic platelet transfusions, haemorrhage remains an important complication during this thrombocytopenic period. Within a 30 day period up to 70% of patients have clinically significant haemorrhage (World Health Organization (WHO) grade 2 or above bleeding) and up to 10% have severe or life-threatening haemorrhage (WHO grade 3 or 4 bleeding). Hence our current management of these patients to prevent haemorrhage is sub-optimal. T

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26

Mak, Stefanie Alexandra [Verfasser], Reinhard [Akademischer Betreuer] Nießner, Peter B. [Gutachter] Luppa, and Reinhard [Gutachter] Nießner. "Incorporation of platelet glycoprotein receptors into lipid bilayer nanodiscs for the detection of autoantibodies in autoimmune thrombocytopenia / Stefanie Alexandra Mak ; Gutachter: Peter B. Luppa, Reinhard Nießner ; Betreuer: Reinhard Nießner." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1202922740/34.

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27

Pilebro, Lappalainen Ida. "A new quick method for screening of HPA-1 based on fluorescence conjugated antibodies." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356042.

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Human platelet antigens (HPA) is located on the platelet surface and they are inherited both from the mother and the father. If a mother who is homozygous for HPA-1b carries a child who has inherited HPA-1a from the father, the mother is in danger to form antibodies against HPA-1a on the fetal platelet. This may cause the child to suffer from neonatal alloimmune thrombocytopenia (NAIT) that could lead to death. This can be prevented by platelet transfusion. EVA Biosensor Technology is a new method for detection of HPA-1 that is currently only approved for scientific research. The aim of this s

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28

Boullu, Lois. "Étude d’équations à retard appliquées à la régulation de la production de plaquettes sanguines." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1239/document.

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L’objectif de cette thèse est d’étudier, à l’aide de modèles mathématiques, le mécanisme de régulation qui permet au corps de maintenir une quantité optimale de plaquettes sanguines. Le premier chapitre présente le contexte biologique et mathématique. Dans un second chapitre, un modèle pour la mégacaryopoïèse est introduit qui suppose une régulation ponctuelle par le nombre de plaquettes du taux de différentiation des cellules souches vers la lignée mégacaryocytaire et du nombre de plaquettes produites par mégacaryocyte. Nous montrons que la dynamique de ce modèle est régie par une équation di

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29

Ghelardi, Isis Raquel. "O uso do agente hemostático a base de quitosana no controle hemorrágico pós-exodontias realizadas em portadores de trombocitopenias." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-28042014-162848/.

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Introdução: Trombocitopenia é a redução dos níveis plaquetários ocasionada por diversas condições, como hepatopatias e a Trombocitopenia Imune (TI), por exemplo. A redução de plaquetas na hepatopatia pode ocorrer devido à deficiência medular por hipovitaminose, aumento do consumo celular e hiperesplenismo e/ou devido à coagulação intravascular disseminada. Na Trombocitopenia Imune, a redução plaquetária ocorre tanto por maior destruição destas células quanto por diminuição medular de sua produção. Portadores de trombocitopenia podem apresentar achados orais como petéquias e/ou equimoses e sang

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30

Sandrock, Kirstin, Ralf Knöfler, Andreas Greinacher, et al. "Novel Mutation in Bernard-Soulier Syndrome." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136606.

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Background: Bernard-Soulier syndrome (BSS) is a severe congenital bleeding disorder characterized by thrombocytopenia, thrombocytopathy and decreased platelet adhesion. BSS results from genetic alterations of the glycoprotein (GP) Ib/IX/V complex. Methods: We report on a patient demonstrating typical BSS phenotype (thrombocytopenia with giant platelets, bleeding symptoms). However, BSS was not diagnosed until he reached the age of 39 years. Results: Flow cytometry of the patient’s platelets revealed absence of GPIb/IX/V receptor surface expression. In addition, immunofluorescence analysis of p

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31

Sandrock, Kirstin, Ralf Knöfler, Andreas Greinacher, et al. "Novel Mutation in Bernard-Soulier Syndrome." Karger, 2010. https://tud.qucosa.de/id/qucosa%3A27717.

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Background: Bernard-Soulier syndrome (BSS) is a severe congenital bleeding disorder characterized by thrombocytopenia, thrombocytopathy and decreased platelet adhesion. BSS results from genetic alterations of the glycoprotein (GP) Ib/IX/V complex. Methods: We report on a patient demonstrating typical BSS phenotype (thrombocytopenia with giant platelets, bleeding symptoms). However, BSS was not diagnosed until he reached the age of 39 years. Results: Flow cytometry of the patient’s platelets revealed absence of GPIb/IX/V receptor surface expression. In addition, immunofluorescence analysis of p

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32

Bätzel, Carolin. "Verbesserung der medizinischen Versorgung und des Outcomes sehr kleiner und leichter Frühgeborener durch klinisches Benchmarking." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15454.

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In der vorliegenden Arbeit wurde anhand der im Rahmen des Vermont-Oxford-Neonatal-Networks erhobenen Daten an der Berliner Klinik für Neonatologie der Charité Campus Mitte und der Abteilung für neonatologische Intensivmedizin der Universitätskinderklinik in Innsbruck ein Benchmarking-Projekt für die Jahre 1997 bis 2001 durchgeführt. Nach der Analyse des Outcomes wurde eine Analyse der externen Evidenz anhand von Literatursuche in PubMed und der Cochrane Datenbank für systematische Reviews durchgeführt. Danach wurde ein Fragebogen entworfen, der gezielt Handlungsstrategien und -richtlinien bezü

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33

Adenwalla, Nazneen. "Analysis of platelets during malaria infection, and their interaction with Plasmodium-infected erythrocytes." Master's thesis, 2017. http://hdl.handle.net/1885/136517.

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Malaria is an infectious disease caused by Plasmodium parasites, transmitted by the female Anopheles mosquito. Malaria can cause mild symptoms as well as more severe complications which may lead to death. Annually, there are half a million deaths worldwide with millions more newly infected with malaria. Although antimalarials exist, due to the prevalence of drug resistance, novel, more effective treatments are needed to combat malaria by aiding the host immune response. One of the earliest signs of a malarial infection is a decrease in the concentration

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34

"Platelet antibodies in immune thrombocytopenia (with special studies on frequencies of platelet-specific antigens in the Chinese)." Chinese University of Hong Kong, 1988. http://library.cuhk.edu.hk/record=b5886642.

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35

Mott, Patrick Joseph. "Anti-CD44 and Anti-platelet Antibodies have Similar but Distinct Effects in the Treatment of a Mouse Model of Arthritis." Thesis, 2012. http://hdl.handle.net/1807/33465.

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Rheumatoid Arthritis (RA) is an autoimmune disease characterized by inflammation and eventual destruction of the synovial joints. The role of platelets in the pathophysiology of arthritis has only recently been established. Because antibodies to CD44 can deplete platelets, we hypothesized that these antibodies might be effective in arthritis through a platelet-depletion mechanism. We examined the K/BxN passive transfer mouse model of arthritis and found that most antibodies against CD44 were capable of depleting platelets. However, anti-CD44 treatment is effective when administered during deve

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36

Lang, Sean. "Pathogenesis of Fetal and Neonatal Immune Thrombocytopenia: Role of Anti-Beta3 Integrin Antibodies in Vascular Injury and Angiogenesis." Thesis, 2012. http://hdl.handle.net/1807/42891.

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Fetal and neonatal immune thrombocytopenia (FNIT) is a severe bleeding disorder which results from fetal platelet destruction by maternal antibodies against platelet antigens, including GPIIbIIIa (αIIbβ3 integrin) and GPIbα. β3 integrin is also expressed by angiogenic endothelial cells (ECs) and is required for angiogenesis. Therefore, we investigated whether anti-β3 antibodies in FNIT cross-react with blood vessels of the fetus/neonate and contribute to pathogenesis. Antibodies to GPIbα were used as controls. To mimic human FNIT, β3 integrin- or GPIbα-deficient female mice were immunized with

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37

Katsman, Yulia. "Improved Mouse Models for the Study of Treatment Modalities using Sulfur-containing Small-molecular-Weight Molecules for Passive Immune-mediated Thrombocytopenia." Thesis, 2009. http://hdl.handle.net/1807/18786.

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Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. To test the efficacy of novel sulfur compounds as alternative treatments for ITP, we used a mouse model of passive immune thrombocytopenia (PIT). Using this model, the platelet nadir could not be maintained, with platelet counts rising after day 4, despite daily anti-platelet antibody administration. We examined reticulated platelet counts by flow cytometry, and found increased thrombopoiesis in the bone marrow to be at least partially responsible for this platelet reboun

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38

Nogueira, Joana Inês Garcia. "O Impacto da Erradicação de Helicobacter pylori em Doentes com Trombocitopenia Imune." Master's thesis, 2018. http://hdl.handle.net/10316/82392.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: A infeção por Helicobacter pylori (Hp) é uma causa secundária de trombocitopenia imune (TI) cuja abordagem terapêutica inclui a pesquisa desta bactéria e a respetiva erradicação. As taxas de resposta a este tratamento rondam os 50%, mas apresentam uma variabilidade geográfica. Este estudo investiga se os pacientes com TI associada à infeção por Hp (TI-Hp+) da região Centro de Portugal beneficiam desta modalidade terapêutica.Metodologia: Foram estudados retrospetivamente 28 adultos com TI-Hp+, co

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39

LIN, YI-LING, and 林怡伶. "Autoantibodies to platelet antigens in patients with autoimmune thrombocytopenia." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/22235255292001229280.

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40

Vaughan, Jenifer Leigh. "Reticulated platelet fraction levels in HIV infected individuals with thrombocytopenia." Thesis, 2011. http://hdl.handle.net/10539/8985.

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MMed, Haematology. University of the Witwatersrand, Faculty of Health Sciences<br>Thrombocytopenia is common among individuals infected with HIV, with a wide range of possible causes. It often necessitates the performance of a bone marrow investigation in order to assess megakaryocyte activity and to exclude the presence of bone marrow infiltration. Unfortunately, meaningful interpretation of the bone marrow findings is often hampered by the frequent co-existence of multiple potential pathogenic processes. For example, megakaryocyte numbers are often well preserved (even in the presence of mar

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Jahangiri, Anila. "Molecular mechanisms that control platelet receptors in people with thrombocytopenia." Master's thesis, 2022. http://hdl.handle.net/1885/274377.

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Platelet receptors are fundamental to the haemostatic properties of platelets. GPIb alpha binds VWF, and GPVI binds collagen, subsequently activating intracellular signalling cascades that culminate in platelet aggregation and clot formation. Pathological shedding of platelet receptors GPVI and GPIb alpha may contribute to platelet dysfunction and increased bleeding risk. Such changes are demonstrated in case reports of patients with acquired autoimmune diseases such as immune thrombocytopenia (ITP) where antibodies target platelets. A single-center, observational analysis was conducted among

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REN, JIN-JIN, and 任晶晶. "Investigations of anti-platelet antibodies in idiopathic thrombocytopenic purpura patients." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/35002976605057943157.

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Peprah, M. A. (Koranteng). "Platelet count trends in pregnant women who have pre-eclampsia with thrombocytopenia." Thesis, 2016. http://hdl.handle.net/10539/22571.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Master of Medicine in Obstetrics and Gynaecology MMed (O&G) Johannesburg, May 2016<br>Background Pre-eclampsia can result in abnormal platelet function and count. Due to lack of resources and the subsequent over burden of specimens sent to our National Health Laboratory Services (NHLS), these results may not be obtained on time. Obstetricians and anaesthetists therefore make assumptions about platelet count in pre-eclamptic women – a common assu

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Stegner, David. "Novel Aspects of Platelet Signaling and of the Pathogenesis of Immune Thrombocytopenia." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-87980.

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This work summarizes the results of studies on three major aspects of platelet signaling and of the pathogenesis of immune thrombocytopenia. Therefore, this thesis is divided into three parts. i) Platelet activation and subsequent thrombus formation at sites of vascular injury is crucial for normal hemostasis, but it can also trigger myocardial infarction and stroke. The initial capture of flowing platelets to the injured vessel wall is mediated by the interaction of the glycoprotein (GP) Ib-V-IX complex with von Willebrand factor (vWF) immobilized on the exposed subendothelial extracellular m

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Trottier, Jessica. "Expansion des mégacaryocytes par HoxB4 pour accélérer la reconstitution plaquettaire." Thèse, 2014. http://hdl.handle.net/1866/12266.

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La greffe de cellules souches hématopoïétiques est parfois le seul traitement efficace contre les cancers hématologiques ainsi que plusieurs autres désordres reliés au système hématopoïétique. La greffe autologue est souvent le traitement de choix pour les patients atteints de lymphome ou de myélome. Dans ce cas, les cellules souches hématopoïétiques (CSH) du patient sont récoltées et congelées. Le patient subit ensuite des traitements de chimiothérapie et/ou radiothérapie qui éliminent les cellules malignes, mais détruisent aussi son système hématopoïétique. Ce dernier sera ensuite rec

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Chihara, Ray K. "Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation." Thesis, 2014. http://hdl.handle.net/1805/5280.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Solid organ transplantation is limited by available donor allografts. Pig to human transplantation, xenotransplantation, could potentially solve this problem if physiologic and immunologic incompatibilities are overcome. Genetic modifications of pigs have proven valuable in the study of xenotransplantation by improving pig to human compatibility. More genetic targets must be identified for clinical success. First, this study examines platelet homeostasis incompatibilities leading to acute thrombocytopenia in liver xenotransplanta

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Li, June. "Anti-GPIbα Mediated Platelet Desialylation and Activation: A Novel Fc-independent Platelet Clearance Mechanism and Potential Therapeutic and Diagnostic Target in ITP". Thesis, 2014. http://hdl.handle.net/1807/65570.

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Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests antibody-mediated platelet destruction occurs in the spleen via Fcγ receptors (FcγR). However, it has been demonstrated that anti-GPIbα-mediated ITP is often refractory to therapies targeting FcγR pathways. Utilizing a panel of murine monoclonal antibodies (mAbs) against murine and human GPIIbIIIa and GPIbα, it was found that anti-GPIbα induces not only platelet activation to a much greater extent than anti-GPIIbIIIa antibodi

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Webster, Michelle. "Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by anti-platelet GPIIbIIIa versus GPIbalpha antibodies." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450530&T=F.

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Chen, Bo-Rung, and 陳柏榮. "The investigation of thrombocytopenia caused by Agkistin, a platelet glycoprotein Ib inhibitor with C-type lectin-like structure." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/59767739772180533470.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>105<br>Platelets act as an indispensable role in hemostasis. Abnormal activation of platelets may lead to formation of threatening thrombus under pathological conditions. Myocardial infarction and ischemic stroke are in high lethal rates each year. Therefore, several antiplatelet agents are indicated for preventing abnormal thrombus formation in daily life or after coronary surgery. However, current anti-platelet agents have the risk of bleeding. For safety issue, thrombus prevention with lower bleeding risk is the concerning issue of new generation antiplatelet agent

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Lindsey, Nigel J., M. Behrendt, M. Hamidpour, L. J. Partridge, and B. Griffiths. "The isolation and characterisation of antiplatelet antibodies." 2006. http://hdl.handle.net/10454/2839.

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No<br>The isolation and characterisation of antiplatelet antibodies in autoimmune thrombocytopenia purpura patients (ITP) is described. Autoimmune thrombocytopenia purpura is an autoimmune disease, clinically defined by low platelet counts, normal or increased megakaryocytopoiesis and antiplatelet antibodies in serum. This study used phage display to isolate Fab antiplatelet antibodies to study the structure-function relationships of pathogenic antibodies in ITP. Out of six randomly selected colonies, four colonies reacted strongly with whole platelets in enzyme-linked immunosorbent assay (ELI

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