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Dissertations / Theses on the topic 'Platelets'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

MacMillan, L. J. M. "Receptor mechanisms common to platelets and platelet progenitor cells." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233116.

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2

Box, Clare Louise. "Interactions between platelets and platelet derived microvesicles in inflamation." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5818/.

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Atherosclerosis is a chronic inflammatory disease, characterised by infiltration of leukocytes and accumulation of fatty deposits in the artery wall. Early events in this disease process include recruitment of platelets to the artery wall, which in turn aid in leukocyte recruitment. However, upon activation platelets release microvesicles (PMV), we are interested in whether PMV have a role in enhancing leukocyte recruitment. We demonstrated using whole blood that upon activation, platelets form aggregates with monocytes and neutrophils. The data suggests that upon platelet activation, PMV may

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3

Taha, Mariam. "Bacterial Contamination of Platelet Concentrates: Role of Biofilm Formation and Manufacturing Process." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35192.

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Bacterial contamination of platelet concentrates (PCs) poses the highest transfusion-associated infectious risk with skin flora, such as Staphylococcus epidermidis and Staphylococcus capitis, being the predominant contaminants. These bacteria are able to form surface-attached aggregates or biofilms, which are present in the skin of healthy blood donors and can subsequently be isolated from contaminated PCs. Disinfection of the venipuncture area before donation with a combination of 2% chlorhexidine-gluconate and 70% isopropanol is used at Canadian Blood Services. However, not all bacteria a

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4

Hayman, Melissa Anne. "Genomic influences on platelet function." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/36221.

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The study of platelet messenger and micro-RNAs is of increasing interest owing to the fact that platelets contain the machinery to splice and translate mRNA into proteins in response to inhibitory or activating signals. However, the relatively small size (roughly 4000-5000 transcripts) and short half-life of the platelet transcriptome makes this a technically challenging aspect of platelet biology to investigate. The aims of these thesis investigations were therefore to optimise protocols for the isolation of platelets for downstream RNA analyses and function testing, to investigate the functi

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5

Hamali, Hassan A. A. "Regulation of the procoagulant activity of platelets and platelet-derived microparticles." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10046.

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Procoagulant microparticles (MPs) in the circulation are increasingly recognized as playing a role in haemostasis and inflammation and may prove useful biomarkers for clinical studies. Platelets are known to generate MPs in response to stimulation, and platelet-derived MPs (PDMPs) form the majority of the MPs found in the normal circulation and can be elevated in a number of disease states. The current study has focused on the procoagulant activity of platelets and PDMPs following stimulation with the collagen-mimetic peptide CRP-XL. Their activity in accelerating thrombin generation can be ac

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6

Murphy, Christine Therese. "Mechanisms of stimulus-response coupling in platelet-activating factor stimulated platelets." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304999.

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7

Arunima, Ghosh. "Role of CD36 in Platelet Function." Cleveland State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=csu1199991110.

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8

Hamad, Osama A. "Crosstalk Between Activated Platelets and the Complement System." Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123681.

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Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. To study the platelet-induced complement activation we developed a system in which platelets were activated by thrombin receptor activating peptide (TRAP) in platelet rich plasma (PRP) or whole blood anti-coagulated using the specific thrombin inhibitor, lepirudin. TRAP-activated platelets induced a fluid-phase complement activation measured as generation of C3a and sC5b-9, triggered by released chondroitin sulphate-A (CS-A) which intera

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9

Battram, Anthony Matthew. "The role and regulation of Rasa3 in platelets and platelet cell models." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702741.

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Upon vascular insult, platelets are recruited to the site of injury, are activated, and form a haemostatic plug to prevent bleeding. However, inappropriate platelet activation can lead to the formation of occluding thrombi in arteries and veins in a process known as thrombosis. The GTPase Rap1 plays a critical role in platelet activation by regulating the affinity state of the fibrinogen receptor, integrin allbb3. The aim of this thesis was to ascertain the role and regulation of a Rap1-targeting GTPase-activating protein (GAP), Rasa3 (previously GAP1lP4BP), in platelet signal transduction and

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10

Eriksson, Andreas. "Platelet Adhesion to Proteins in Microplates : Applications in Experimental and Clinical Research." Doctoral thesis, Linköping : Department of Medical and Health Sciences, Linköping University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11733.

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11

Cicmil, Milenko. "Platelet endothelial cell adhesion in molecule -1 (PECAM-1/CD31) signalling in platelets." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270922.

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12

Edwards, Rebecca Susan. "Synthesis of graphene platelets." Thesis, Durham University, 2015. http://etheses.dur.ac.uk/11132/.

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Graphene, a single-layer of graphite, is frequently termed a ‘wonder material’ due to the wide range of extraordinary properties it possesses and the potential it has for uses in a broad variety of different applications. Key to the realisation of graphene’s use in applications is the ability to produce large scale quantities of graphene with consistent quality, which remains a challenge to the field. The aim of this thesis was to investigate the synthesis of graphene via a number of different methodologies in order to develop novel techniques that are suitable to scale and that provide graphe

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13

Joutsi-Korhonen, Lotta. "Autoimmune thrombocytopenia : detection of platelet-associated IgG, reticulated platelets and platelet Fcg[gamma] receptor polymorphism in thrombocytopenic patients." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/joutsi-korhonen/.

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14

Bunescu, Andreia. "Cellular markers indicating activation of the hemostatic system : studies on platelets and leukocytes in peripheral human blood /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-759-2/.

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15

Tohidi-Esfahani, Ibrahim. "Molecular profiling and characterisation of the procoagulant platelet subpopulation." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29642.

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Platelets play a major role in thrombotic disorders, with current antiplatelet agents limited by bleeding complications. The procoagulant platelet, implicated in thrombosis, has little role in haemostasis and specifically targeting it could improve thrombotic outcomes. This work aimed to develop a method to isolate procoagulant platelets, interrogate the transcriptome to identify key biological pathways for the formation of the subpopulation, and evaluate the pathways in downstream experiments. RNA-sequencing of healthy donor platelets identified >1000 genes differentially expressed between

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16

VISMARA, MAURO. "Blood platelets and cancer: the involvement of platelet-derived extracellular vesicles in tumour progression." Doctoral thesis, Università degli studi di Pavia, 2021. http://hdl.handle.net/11571/1425254.

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In addition to their roles in haemostasis and thrombosis, blood platelets have been extensively implicated in the progression of cancer. During metastasis, circulating tumour cells (CTCs) induce platelet activation and aggregation, that are exploited to increase cancer dissemination though multiple mechanisms [1, 2]. Platelet-derived extracellular vesicles (PEVs) are shed from platelet membrane in response to extracellular stimuli and carry important biological signals to recipient cells. In vitro, cancer cells induce the release of PEVs and, accordingly, cancer patients display increased lev

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17

Ledent-Semple, Elisabeth. "A study of factors influencing the quality of blood products during preparation, storage and filtration /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med667s.pdf.

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18

McGrath, Brianna. "A mechanobiological investigation of platelets." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28299.

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To investigate the mechanical behavior of platelets in response to an applied force, the deformation capacity of the membrane, as quantified by membrane progression into a borosilicate glass micropipette of defined internal diameter, is probed using a controlled range of negative pressure (0--7 cm H2O). In real-time, murine platelet membranes fail to demonstrate viscoelastic effects, but maintain an average linear deformation behavior (n = 11 platelets). Along with published deformation data using human platelets, a novel constitutive model generates a set of optimized material constants that

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19

Law, Robert. "PDE3A signalling in blood platelets." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13761.

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Cyclic 3’, 5’ adenosine monophosphate (cAMP) signalling downstream of prostacyclin (PGI₂) is a key inhibitory pathway in blood platelets. This pathway is dynamically regulated by phosphodiesterase 3A (PDE3A), which hydrolyses cAMP into metabolically inactive AMP. Although PDE3A is an established drug target in anti-platelet therapies, the molecular mechanisms that underlie its function in platelets remain unclear. Therefore, the major aim of this study was to further explore PDE3A signalling in human platelets. Using a combination of cell fractionation and immunoblotting we identified two PDE3

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20

MacKenzie, Amanda Barbara. "Ion channels in human platelets." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627035.

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21

Stott, Andrew James. "Studies on human blood platelets." Thesis, University of Warwick, 1990. http://wrap.warwick.ac.uk/57766/.

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This project was undertaken to increase the understanding of platelet function, with paticular emphasis on abnormal platelets in diabetes mellitus, and improving the quality of platelet concentrates for transfusion. {1} Potential platelet antagonists, including PGE1, verapamil, insulin and hirudin, were added to platelet concentrates in an attempt to improve the recovery and shelf-life of the concentrate. Each "preservative" caused some improvement in platelet concentrate quality, as measured by functional tests, and radio-immunoassay for the platelet activation marker, B- thromboglobulin. The

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22

Tatsis, A. "Hydraulic conveying of metallic platelets." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/46749.

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23

Chang, Karin. "Platelets and Serotonin in Migraine." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1279586929.

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24

Kremer, Hovinga Johanna Anna. "Malondialdehyd fomation by blood platelets /." Bern, 1990. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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25

Hille, Laura [Verfasser], and Dietmar [Akademischer Betreuer] Trenk. "Intrinsic properties of reticulated platelets." Freiburg : Universität, 2020. http://d-nb.info/122441652X/34.

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26

Bhavaraju, Kamala. "MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/92746.

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Molecular and Cellular Physiology<br>Ph.D.<br>Cardiovascular diseases are a major cause of mortality and morbidity in the developed countries. Anti-platelet therapy is a cornerstone treatment for patients with cardiovascular diseases. Patients are routinely managed with a combination therapy consisting of aspirin and clopidogrel. Aspirin inhibits cyclooxygenase 1 (COX 1) a crucial intermediate enzyme involved in thromboxane biosynthesis. Clopidogrel on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet a

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27

Milovanovic, Micha. "Platelets : with special reference to platelet density subpopulations, stable coronary heart disease and atrial fibrillation." Doctoral thesis, Linköpings universitet, Hälsa, Aktivitet, Vård (HAV), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62630.

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The current thesis was divided into two parts. Basic platelet research is the topic of the first section. The subsequent clinical part examines platelet reactivity in stable angina pectoris (AP) and in atrial fibrillation. Platelet heterogeneity was investigated in the first section (papers 1 and 2). The cells were separated according to density using linear Percoll™ (a density medium) gradients. The latter contained EDTA, prostaglandin E1 and theophylline to prevent platelet in vitro activity. The platelet population was then divided into density subpopulations (n = 16 - 20). Membrane attache

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28

Forsyth, Sara. "The effect of exercise on the concentration of platelets in a platelet rich plasma preparation." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40420.

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Traumatic tendon injuries and tendinopathy are common problems in sports medicine practice. The active population seeks minimally invasive treatments that speed healing time. New strategies, such as platelet-rich plasma (PRP) therapies, may achieve this. The use of PRP in sports medicine has been stimulated by the advancing knowledge regarding the role of growth factors (GF) in tissue repair. GF concentration is thought to increase linearly with platelet concentration (Eppley et al., 2004). Several studies are emerging with favourable outcomes in injection of PRP into the area of injury (Ko

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29

Sink, Carolyn A. "Canine Platelet Concentrates: An In Vitro Study to Effectively Provide a Source of Functional Platelets." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/31620.

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This study monitored the storage lesion of 15 units of canine platelet concentrates harvested by differential centrifugation. Canine platelet concentrates were stored at 20-24Â° C in a platelet rotator for a total of 9 days; the storage lesion of three second generation platelet storage containers was compared. The battery of in vitro tests used to monitor the storage lesion were selected from previous studies performed with human platelet concentrates separated by differential centrifugation. Based on these tests, canine platelet concentrates exhibited a storage lesion similar to human pla

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30

Bienz, Denise Edith. "Human blood platelets : the role of glycoproteins in the platelet interaction with thrombin and collagen /." [S.l.] : [s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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31

Bateson, E. A. J. "Cryopreservation of platelets : investigation of factors affecting recovery and function of frozen and thawed platelets." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233520.

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32

Truss, Nicola Jane. "The effect of vascular cells on platelets and an assessment of platelet activity in clinical settings." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511338.

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33

Li, Melissa. "Microfluidic system for thrombosis under multiple shear rates and platelet therapies." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52154.

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Thrombosis is the pathological formation of platelet aggregates that cause stroke and heart attack\textemdash the leading causes of death in developed nations. Determining effective dosages for platelet therapies (e.g. aspirin, Integrilin, and Plavix) to prevent thrombosis is a persistent medical challenge (studies estimate up to 45% of patients exhibit insufficient responses to these drugs) and recent studies have implicated pathological flow conditions of high shear rates and stenosis morphology as primary factors. However, there are currently no diagnostic instruments able to recapitulate

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34

Vanags, Daina M. "Adrenergic and serotonergic potentiation of platelet aggregation /." Title page, summary and contents only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phv217.pdf.

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35

Sayeur, Mathieu. "Mechanical Modeling of Human Platelets Membrane." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32876.

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In an effort to help understand the mechanical properties of human platelets, their deformations were measured using micropipette experiments over an aspiration pressure range of 1-5 cmH2O, in steps of 1 cmH2O. The experiments confirmed the previously reported linear relationship between deformation and pressure. The experimental results were used to determine the material constants of a thin-axisymmetric shell model based on a strain-energy constitutive relation to describe the platelet deformations under aspiration. The model was successful in capturing the experimental deformations. It also

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36

Inamdar, Vaishali Vijay. "FUNCTIONAL PROTEIN TYROSINE PHOSPHATASES IN PLATELETS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/473257.

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Biomedical Sciences<br>Ph.D.<br>Platelets are small anucleate cells in blood that are derived from megakaryocytes and their primary function is to prevent bleeding. Upon vascular injury, the sub-endothelial collagen gets exposed to which platelets bind and aggregate eventually forming a platelet plug. There are several receptors on platelet surface that can be divided into two broad categories; the immune-receptor tyrosine-based activation motif (ITAM) and the G protein-coupled receptors (GPCRs). The role of several protein tyrosine kinases (PTKs) downstream of ITAM and GPCRs has been extensiv

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37

Samiei, Mitra. "Characterization of protein kinases in platelets." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/NQ46416.pdf.

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38

Nyarko, Kwasi Agyepong. "Bovine platelets, activation and signaling mechanisms." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58308.pdf.

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39

Comfurius, Paul. "Phospholipid flip-flop in activated platelets." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5515.

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40

Ding, Y.-A. "Angiotensin II receptors in human platelets." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372369.

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41

Grunkemeier, John M. "Effect of adhesion proteins and surface chemistry on the procoagulant state of adherent platelets /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8087.

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42

Lisiak, Karolina. "The role of platelets in the activation of TAFI in model thrombi." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24805.

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43

Coimbra, Leila Santana. "Influência de drogas antiplaquetárias na reparação da doença periodontal experimental em ratos /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/95389.

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Orientador: Luís Carlos Spolidorio<br>Banca: Joni Augusto Cirelli<br>Banca: Raquel Fernanda Gerlach<br>Resumo: O objetivo deste trabalho foi avaliar o efeito da administracao da aspirina (Asp), do clopidogrel (Clo) e da ticlopidina (Tic) sobre o processo de reparacao dos tecidos periodontais apos inducao experimental de periodontite em ratos. Primeiramente avaliou-se a acao destas drogas sobre a expressao das citocinas pro-inflamatorias: TNF-α, IL-6 e TXA2 no tecido gengival de 25 ratos subdivididos em 5 grupos (n=5), 15 dias apos a instalacao da ligadura ao redor do primeiro molar inferior. P

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44

Hartley, Paul Steven. "Factors affecting the viability of human platelets." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/24685.

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Human platelets die in vitro in a caspase-independent manner with features of necrosis. Little is known about the factors affecting the mode of platelet death nor how death is brought about. This thesis aimed to generate novel tools for the discrimination of live from dead platelets and to evaluate the role of autophagy, temperature and sugar metabolism in the demise of platelets in vitro. Three dyes, 10-nonyl acridine orange, calcein and FM 4-64 were found to be useful for the evaluation of platelet viability. It was found that during in vitro storage dead platelets formed metalloproteinase-d

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45

Kamath, Sridhar. "A study of platelets in atrial fibrillation." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270055.

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46

Zagai, Ulrika. "Platelets and eosinophils in lung tissue remodelling /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-841-X/.

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47

Webb, Rachel J. "Characterisation of P2-receptors on human platelets." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342989.

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48

Marshall, Stuart J. "GPIb-mediated tyrosine phosphorylation in human platelets." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275467.

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49

Fulkerson, Zachary Bennett. "LYSOPHOSPHATIDIC ACID PRODUCTION AND SIGNALING IN PLATELETS." UKnowledge, 2011. http://uknowledge.uky.edu/physiology_etds/1.

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Lysophosphatidic acid (LPA) belongs to a class of extracellular lipid signaling molecules. In the vasculature, LPA may regulate platelet activation and modulate endothelial and smooth muscle cell function. LPA has therefore been proposed as a mediator of cardiovascular disease. The bulk of circulating LPA is produced from plasma lysophosphatidylcholine (LPC) by autotaxin (ATX), a secreted lysophospholipase D (lysoPLD). Early studies suggest that some of the production of circulating LPA is platelet-dependent. ATX possesses an N-terminal somatomedin B-like domain suggesting the hypothesis that

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50

Peters, Mark John. "The role of platelets in acute inflammation." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271069.

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