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Journal articles on the topic 'Play Novel: Silent Hill'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Ward, Caleb. "Substances in Play." Screen Bodies 10, no. 1 (2025): 107–14. https://doi.org/10.3167/screen.2025.100109.

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Abstract This article examines Timothy Crick's notion of the game body, thinking beyond the visuality that defines cinematic “film body,” an embodied subject–object that mediates the sensation of a film to the viewer. Examining Silent Hill 2, a game that resists legibility and indexicality, this article argues that the “game body” is mediated through substances. Silent Hill 2’s uncanny appeal to place memory demonstrates that there is an ontological distinction between the player's body and the game body, requiring a degree of translation to the experience of sensing virtual space. The player'

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2

Sinoimeri, Lea. "“Ill-Told Ill-Heard”: Aurality and Reading in." Samuel Beckett Today / Aujourd'hui 24, no. 1 (2012): 321–34. http://dx.doi.org/10.1163/18757405-024001022.

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This paper investigates the question of aurality in Beckett's narrative and radiophonic works of the early sixties. It focuses on and its English translation , considered here as a central work in Beckett's intermedial practice of hybridisation between genres and media. At the cross-roads between a novel and a radio play, between written and spoken word, enacts the performance of the reader as a silent listener. Corporality and language overlap in the text as the novel builds up the metaphor of the human body as a medium.

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Torres, Adrian Gabriel. "Enjoy the Silence: Nearly Half of Human tRNA Genes Are Silent." Bioinformatics and Biology Insights 13 (January 2019): 117793221986845. http://dx.doi.org/10.1177/1177932219868454.

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Transfer RNAs (tRNAs) are key components of the translation machinery. They read codons on messenger RNAs (mRNAs) and deliver the appropriate amino acid to the ribosome for protein synthesis. The human genome encodes more than 500 tRNA genes but their individual contribution to the cellular tRNA pool is unclear. In recent years, novel methods were developed to improve the quantification of tRNA gene expression, most of which rely on next-generation sequencing such as small RNA-Seq applied to tRNAs (tRNA-Seq). In a previous study, we presented a bioinformatics strategy to analyse tRNA-Seq datas

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Raha, Oindrila, B. N. Sarkar, P. Veerraju, Lucy Pramanik, and V. R. Rao. "Identification of novel single nucleotide polymorphism (SNP) in DPB1 gene in ethnic population from West Bengal." Genetika 43, no. 1 (2011): 205–8. http://dx.doi.org/10.2298/gensr1101205r.

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HLA-DP antigens present peptides to CD4+ T cells and play an important role in autoimmune diseases and parasitic infections. We have sequenced HLA-DPB1 exon-2 from the ethnic populations in West Bengal, India and report a novel single nucleotide polymorphism (SNP) - rs111221466. The rs111221466 SNP induced silent mutation from CGA (Arg) to TGA (Stop Codon) and showed a frequency of 83.24%. In conventional sense, the frequency of novel SNP is very high. We have sequenced HLA-DPB1 exon-2 from a Bengali Population in West Bengal, India. HLA-DP antigens present peptides to CD4+ T cells and play an

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A, Raja Mohammed. "Ecology in Lakshmi Saravanakumar's novel ‘Kanagan’." International Research Journal of Tamil 4, S-7 (2022): 20–25. http://dx.doi.org/10.34256/irjt22s74.

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The primary cause of deforestation is Man and also, he is the first to suffer from deforestation. The study is set to illustrate this under the title ‘Ecology in the Kanagan novel’. The novel sets out to explain who is responsible for deforestation and why they are doing it. The destruction of elephants at the instigation of big bosses also highlights the irresponsibility of forest officials who do not see them. The novel also reveals that the hill people, ‘Pali’, are being blamed for the ongoing deforestation and killing of elephants for their selfish ends. Along with these, the medical team

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6

Martimort, David, and Salvatore Piccolo. "The Strategic Value of Quantity Forcing Contracts." American Economic Journal: Microeconomics 2, no. 1 (2010): 204–29. http://dx.doi.org/10.1257/mic.2.1.204.

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We explore the strategic value of quantity forcing contracts in a manufacturer-retailer environment under both adverse selection and moral hazard. Manufacturers dealing with (exclusive) competing retailers may prefer to leave contracts silent on retail prices, whenever other aspects of the retailers' activity remain nonverifiable. Two effects are at play when moving from retail price maintenance to quantity forcing. First, restricting screening possibilities may increase retailers' rent. Second, such a restriction affects downstream competition. This latter effect may justify using quantity fo

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Guo, Xiaopeng, Weiqiang Liang, Chunxia Ma, Yuanli Zhao, and Bing Xing. "TMET-04. METABOLOMICS ANALYSIS IN FUNCTIONING AND SILENT CORTICOTROPH ADENOMAS USING A TWO-DIMENSIONAL NANOMATERIAL HIGH-THROUGHPUT PLATFORM." Neuro-Oncology 26, Supplement_8 (2024): viii288. http://dx.doi.org/10.1093/neuonc/noae165.1142.

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Abstract Functioning pituitary corticotroph adenomas (CAs) originated from T-PIT lineage with an ACTH-positive staining cause Cushing’s Disease. However, silent CAs (SCAs) baring the same histological features present clinically non-functioning with more aggressive courses. Metabolites within the tumor microenvironment play critical roles in regulating tumor behaviors and responses to therapy. Understanding their distribution and concentration provides valuable insights for diagnosis and treatment. This study investigated metabolite patterns in functioning and silent CAs. We developed a novel

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8

Kulakevych, L. "The genre features of Maik Yohansen’s “The Adventures of MacLayston, Harry Rupert, and Others” as a first Ukrainian print series." Studia Philologica 1, no. 14 (2020): 100–106. http://dx.doi.org/10.28925/2311-2425.2020.1415.

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The article considers the research results of Maik Yohansen’s “The Adventures of MacLayston, Harry Rupert, and Others”. The work is adventurous with the inherent intricate storylines, fast-paced events, exotics, ect. in this genre. The universal element of the novel is the travels. The novel was published in separate editions by the author’s plan, and it gives reason to determine this work as a first Ukrainian print series (a feuilleton novel, a novel with a sequel). The article states the defining feature of an artistic text is its intermedia, that manifests in the orientation at the methods

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9

Windharto, Antonius Wisnu Yoga. "Nationalism and Familyhood: the Struggle against Authoritarian Government as Seen in Leila Chudori�s Laut Bercerita." Indonesian Journal of English Language Studies (IJELS) 4, no. 2 (2019): 63–68. http://dx.doi.org/10.24071/ijels.v4i2.2304.

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Social injustice is the reason why people protest against the government. The activists seek to find the equality from the government. As the result, some of activists were abducted and killed by the soldiers. The activists are not the group of people who hate the country. Most of them are nationalists, and they cannot keep silent in seeing the injustice in front of their eyes. The family of the activists also play important role in shaping the activists. The connection between the members of family is important in shaping their nationalism. Laut Bercerita is a novel which talks about national

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10

Pinar, Alex. "Russian Literature in Japanese Film: Cross-cultural Adaptations in the Silent Era." Nuevas Poligrafías. Revista de Teoría Literaria y Literatura Comparada, no. 8 (September 20, 2023): 59–76. http://dx.doi.org/10.22201/ffyl.29544076.2023.8.1893.

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Since the beginning of the film industry in Japan, many short films and movies based on Western literary works were made, especially during the 1910s and 1920s. Several of those films were based on fashionable Russian literary works that had been staged in Shingeki (new drama) theaters. This study examines the adaptations of Russian literature produced from the early 1910s until the end of the silent-film era in the 1930s, focusing specifically on films based on Tolstoy’s novel Resurrection, the drama The Living Corpse, and Gorky’s play The Lower Depths. It is shown that the early adaptations,

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11

Issaka, Charity Azumi, Confidence Gbolo Sanka, and Portia Siaw Oppong. "Interrogating The Discourse of Power and Its Resistance in Nawal El Sadaawi’s God Dies by The Nile." Language Circle: Journal of Language and Literature 17, no. 2 (2023): 242–54. http://dx.doi.org/10.15294/lc.v17i2.42520.

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This paper employs Foucault’s theory on Discourse, Power and Knowledge to highlight the powers shaping the Egyptian woman in God Dies by the Nile. The paper also uses the feminist theory in identifying the ways that the Egyptian woman uses to resist the discourse of power in the narrative. The paper therefore focuses on the power dynamics in the novel. Thus questions addressed in this paper include: how the discourses of family, society and religion are generated in the novel; how patriarchy shapes the discourse of power in the narrative and the subtle means used by women to resist and play ou

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Issaka, Charity Azumi, Cofidence Gbolo Sanka, and Elvis Resque. "INTERROGATING THE DISCOURSE OF POWER AND ITS RESISTANCE IN NAWAL EL SADAAWI’S GOD DIES BY THE NILE." International Journal of Humanity Studies (IJHS) 6, no. 2 (2023): 194–212. http://dx.doi.org/10.24071/ijhs.v6i2.5433.

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This paper employs Foucault’s theory on Discourse, Power, and Knowledge to highlight the powers shaping the Egyptian woman in God Dies by the Nile. The paper also uses the feminist theory in identifying the ways that the Egyptian woman uses to resist the discourse of power in the narrative. The paper, therefore, focuses on the power dynamics in the novel. Thus questions addressed in this paper include: how the discourses of family, society, and religion are generated in the novel; how patriarchy shapes the discourse of power in the narrative, and the subtle means used by women to resist and pl

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Priyadharshini, V., R. Ayyasamy, and C. Kathirvelu. "Bioefficacy of ethiprole + pymetrozine against the white-backed planthopper Sogatella furcifera (Howard), in rice (ADT – 46)." Journal of Applied and Natural Science 14, no. 1 (2022): 73–82. http://dx.doi.org/10.31018/jans.v14i1.3185.

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The nymphs and adults of white-backed planthoppers (Sogatella furcifera, Howard) remove plant sap resulting in yield loss. Indiscriminate use of insecticides, results in the development of resistance by insects and ill effects on the environment opening the new era of chemicals with novel modes of action with good bioefficacy, higher selectivity, low mammalian toxicity and safety to the environment. Therefore, the introduction of newer insecticide molecules with alternate modes of action will play a serious role in pest management programs. Hence, an experiment was conducted to evaluate the bi

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Eram Jamil, Humaira Afzal, Saima Bibi, and Farwa. "INTERPLAY OF COERCION AND CONSENT IN A DOLL’S HOUSE." Inception - Journal of Languages and Literature 1, no. 1 (2021): 21–30. http://dx.doi.org/10.36755/ijll.v1i1.22.

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The paper aims to examine the interplay of consent and coercion in the play A Doll’s House through the perspective of Althusser’s theory the ideological state apparatus and oppressive state apparatus. The problem of research is to find the systematic exploitation of women through ideological tool and oppressive tool by men. The research is qualitative based and content analysis is used as tool in this research. The objectives of the research are to explore the use of consent and coercion by male on the female and to examine the interplay of consent and coercion tools as systematic exploitation

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Eram Jamil, Humaira Afzal, Saima BiBi, and Farwa. "INTERPLAY OF COERCION AND CONSENT IN A DOLL’S HOUSE." Inception - Journal of Languages and Literature 1, no. 1 (2021): 21–30. http://dx.doi.org/10.36755/ijll.v1i1.13.

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The paper aims to examine the interplay of consent and coercion in the play A Doll’s House through the perspective of Althusser’s theory the ideological state apparatus and oppressive state apparatus. The problem of research is to find the systematic exploitation of women through the ideological tool and oppressive tools by men. The research is qualitatively based and content analysis is used as tool in this research. The objectives of the research are to explore the use of consent and coercion by male on female and to examine the interplay of consent and coercion tools as systematic exploitat

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16

Rose Putri Safana, Iftinan. "Wokewashing and Greenwashing: The Silent Architects of Eco-apartheid in Mbue’s How Beautiful We Were." ELS Journal on Interdisciplinary Studies in Humanities 8, no. 1 (2025): 8–20. https://doi.org/10.34050/els-jish.v8i1.42803.

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A positive image is very necessary for a company to promote its values and be accepted in society. However, if the positive image narrated is contrary to reality, then the case can be categorized as green-washing, if it concerns the environment, and woke-washing, if it concerns social welfare. Furthermore, literary works as a mirror of society have room to represent green-washing and woke-washing, one of which is in the novel How Beautiful We Were by Mbue. In the novel, green-washing and woke-washing are not just image manipulation for profit but also play a major role in perpetuating eco-apar

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Eissa, Mostafa Essam. "The Silent Scream of Skin Cells: A Brief Review of Slow Electrical Signaling in the Epithelium." Yemen Journal of Medicine 04, no. 01 (2025): 95–104. https://doi.org/10.63475/yjm.v4i1.0039.

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Epithelial cells, lining the skin and internal organs, play a crucial role as protective barriers and regulators of substance transport. Traditionally, these cells were not considered to employ electrical signaling for communication. However, recent investigations have unveiled that epithelial cells generate slow electrical signals, termed the "silent scream," in response to injury, thus challenging conventional views of intercellular communication. A recent experimental investigation provided compelling evidence for this phenomenon, demonstrating the ability of these cells to transmit electri

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Eissa, Mostafa Essam Ahmed Mostafa. "The Silent Scream of Skin Cells: A Brief Review of Slow Electrical Signaling in the Epithelium." Yemen Journal of Medicine 4, no. 1 (2025): 95–1043333333333333333333. https://doi.org/10.63475/yjm.v4i1.0039.

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Epithelial cells, lining the skin and internal organs, play a crucial role as protective barriers and regulators of substance transport. Traditionally, these cells were not considered to employ electrical signaling for communication. However, recent investigations have unveiled that epithelial cells generate slow electrical signals, termed the "silent scream," in response to injury, thus challenging conventional views of intercellular communication. A recent experimental investigation provided compelling evidence for this phenomenon, demonstrating the ability of these cells to transmit electri

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19

Cladel, Nancy M., Xuwen Peng, Neil Christensen, and Jiafen Hu. "The rabbit papillomavirus model: a valuable tool to study viral–host interactions." Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1773 (2019): 20180294. http://dx.doi.org/10.1098/rstb.2018.0294.

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Cottontail rabbit papillomavirus (CRPV) was the first DNA virus shown to be tumorigenic. The virus has since been renamed and is officially known as Sylvilagus floridanus papillomavirus 1 (SfPV1). Since its inception as a surrogate preclinical model for high-risk human papillomavirus (HPV) infections, the SfPV1/rabbit model has been widely used to study viral–host interactions and has played a pivotal role in the successful development of three prophylactic virus-like particle vaccines. In this review, we will focus on the use of the model to gain a better understanding of viral pathogenesis,

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20

Kurian, Alwin M., Munachimso J. Onuorah, and Habib M. Ammari. "Optimizing Coverage in Wireless Sensor Networks: A Binary Ant Colony Algorithm with Hill Climbing." Applied Sciences 14, no. 3 (2024): 960. http://dx.doi.org/10.3390/app14030960.

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Wireless sensor networks (WSNs) play a vital role in various fields, but ensuring optimal coverage poses a significant challenge due to the limited energy resources that constrain sensor nodes. To address this issue, this paper presents a novel approach that combines the binary ant colony algorithm (BACA), a variant of ant colony optimization (ACO), with other search optimization algorithms, such as hill climbing (HC) and simulated annealing (SA). The BACA is employed to generate an initial solution by emulating the foraging behavior of ants and the pheromone trails they leave behind in their

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Seidl, Bernhard, Katrin Rehak, Christoph Bueschl, et al. "Gramiketides, Novel Polyketide Derivatives of Fusarium Graminearum, Are Produced during the Infection of Wheat." Journal of Fungi 8, no. 10 (2022): 1030. http://dx.doi.org/10.3390/jof8101030.

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The plant pathogen Fusarium graminearum is a proficient producer of mycotoxins and other in part still unknown secondary metabolites, some of which might act as virulence factors on wheat. The PKS15 gene is expressed only in planta, so far hampering the identification of an associated metabolite. Here we combined the activation of silent gene clusters by chromatin manipulation (kmt6) with blocking the metabolic flow into the competing biosynthesis of the two major mycotoxins deoxynivalenol and zearalenone. Using an untargeted metabolomics approach, two closely related metabolites were found in

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Ropero, Paloma, Fernando Ataúlfo González, Jorge M. Nieto та ін. "C>A substitution in NT 46 of the 3’ UTR region (the α complex protected region) of the alpha-1 globin gene: a non-deletional mutation or polymorphism?" Journal of Clinical Pathology 73, № 1 (2019): 14–16. http://dx.doi.org/10.1136/jclinpath-2019-206004.

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AimsUntranslated regions (UTRs) play an important role in post-transcriptional regulation of gene expression, including by modulating messenger RNA (mRNA) transport out of the nucleus, translation efficiency, subcellular localisation and stability. Any mutation in this region could alter the stability of mRNA and thereby affect protein synthesis. We analysed if a mutation located in the α complex protected region of the α1 globin gene could cause non-deletional α-thalassaemia by affecting post-transcriptional stability (mRNA stability).MethodsA total of 14 patients without anaemia, normal or s

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Hazarika, Lima. "Molecular docking analysis of arjunolic acid from Terminalia arjuna with a coronary artery disease target APOE4." Bioinformation 17, no. 11 (2021): 949–58. http://dx.doi.org/10.6026/97320630017949.

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Apo lipoprotein-E (APOE) encoded by APOE gene, is a plasma glycoprotein of 34.15 kDa and has a significant genetic association in coronary artery disease (CAD) progression. The silent epidemic of different cardiovascular diseases including CAD challenges novel therapeutic alternatives to prevent to treat chronic conditions of the disease and its associated complications. It is believed that natural phyto compounds and extracts have been a potential source of treating health conditions and have been practiced since several decades. The aim of the study is to identify phyto compounds having sign

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Cohen-Kfir, Einav, Hanna Artsi, Avi Levin, et al. "Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor." Endocrinology 152, no. 12 (2011): 4514–24. http://dx.doi.org/10.1210/en.2011-1128.

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Sirt1, the mammalian ortholog of the yeast Sir2 (silent information regulator 2), was shown to play an important role in metabolism and in age-associated diseases, but its role in skeletal homeostasis and osteoporosis has yet not been studied. Using 129/Sv mice with a germline mutation in the Sirt1 gene, we demonstrate that Sirt1 haplo-insufficient (Sirt1+/−) female mice exhibit a significant reduction in bone mass characterized by decreased bone formation and increased marrow adipogenesis. Importantly, we identify Sost, encoding for sclerostin, a critical inhibitor of bone formation, as a nov

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निरौला Niroula, यज्ञेश्वर Yagyeshwar. "कालो पहाड उपन्यासमा पहिचान र वर्चस्व (Identity and Dominance in the Novel Kalo Pahad (Black Hill))". Bouddhik Abhiyan (बौद्धिक अभियान) 8, № 01 (2023): 82–97. http://dx.doi.org/10.3126/bdkan.v8i01.57794.

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प्रजापति तिमिल्सिनाका ‘अनेरुवा’, ‘विधवा वासना’ र ‘कालो पहाड’ उपन्यास र ‘चिठी’ प्रबन्ध सङ्ग्रह प्रकाशित छन् । उनका उपन्यास सामाजिक यथार्थवाद तथा मनोविज्ञानमा आधारित छन् । यस लेखमा सीमान्तीयताका आधारमा प्रजापति तिमिल्सिना लिखित ‘कालो पहाड’ उपन्यासमा रहेको प्रमुख चरित्र माइलालाई केन्द्र बनाएर यसै पात्रको पहिचान तथा सीमान्त अवस्थालाई अध्ययन गरिएको छ । सीमान्तीयताको आधारमा साहित्यको सांस्कृतिक अध्ययन र ऐतिहासिक पुनव्र्याख्या गर्ने प्रचलन दोस्रो विश्वयुद्धपछि सुरु भएको र सन् असीको दशकदेखि सवाल्टर्न अध्ययनका रूपमा चलेको हो । दोस्रो विश्वयुद्धपछिको विश्वमा हरेक मानव समाजसम्बद्ध विषय क्षेत्रलाई हेर्ने

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Dr.Ameer, Ahmad Khan. "The Colourful Conciliation in Alice Walker's The Color Purple." Global Journal of Arts Humanity and Social Sciences 2, no. 4 (2022): 219–22. https://doi.org/10.5281/zenodo.6480873.

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<em>The Color Purple</em> is a rewriting of the powerful patriarchal order existed in the Afro-American community. The age old struggle for liberation and assertion of individuality as a human being is a terrible battle waged by the Black community in the colonized communities, particularly in the White dominated societies. The coloured people are always an object of ill-treatment and sexual harassment. Even the evangelical people also misused the natives. But the Harlem Renaissance opened new vistas for counter propaganda. Many glittering literary luminaries from the Black community emerged a

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Pandey, Manisha, Hira Choudhury, Azila Abdul-Aziz, et al. "Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent Update on Potential Investigation." Pharmaceutics 13, no. 1 (2020): 1. http://dx.doi.org/10.3390/pharmaceutics13010001.

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The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially if immunodeficient. Globally, there are 1.5 million new cases and forty thousand visual impairment cases reported yearly. The Herpetic Eye Disease Study recommends topical antiviral as the front-line therapy for HSV keratitis. Ironically, topical eye solutions undergo rapid nasolacrimal clearance, w

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Kangwa, Muma I. M., Bailey Robin, Nyalazi I. M. Jessie, et al. "Myocilin Mutations in a Zambian Population Attending Selected Referral Eye Health Facilities." Global Academic Journal of Medical Sciences 4, no. 3 (2022): 45–55. http://dx.doi.org/10.36348/gajms.2022.v04i02.003.

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Purpose: Research has shown that primary open-angle glaucoma (POAG) in Zambia has an earlier age of onset and is more clinically severe than in Europe and the United States of America. Mutations of Myocilin have been reported to be associated with POAG in multiple populations. We therefore, investigated the role of myocilin gene mutations in Primary Open Angle Glaucoma in a Zambian population. Methods: The unrelated POAG patients and unaffected controls seen at the University Teaching Hospitals Eye Hospital, Kitwe Teaching Eye Hospital and Lusaka Eye Hospital were recruited for this study. Gla

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Hall, Barry G. "Selection, adaptation, and bacterial operons." Genome 31, no. 1 (1989): 265–71. http://dx.doi.org/10.1139/g89-044.

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Bacteria are especially useful as systems to study the molecular basis of adaptive evolution. Selection for novel metabolic capabilities has allowed us to study the evolutionary potential of organisms and has shown that there are three major "strategies" for the evolution of new metabolic functions. (i) Regulatory mutations may allow a gene to be expressed under unusual conditions. If the product ofthat gene is already active toward a novel resource, then a regulatory mutation alone may confer a new metabolic capability. (ii) Structural gene mutations may alter the catalytic properties of enzy

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Dhaliwal, Salwinder Singh, Vivek Sharma, Arvind Kumar Shukla, et al. "Biofortification—A Frontier Novel Approach to Enrich Micronutrients in Field Crops to Encounter the Nutritional Security." Molecules 27, no. 4 (2022): 1340. http://dx.doi.org/10.3390/molecules27041340.

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Globally, many developing countries are facing silent epidemics of nutritional deficiencies in human beings and animals. The lack of diversity in diet, i.e., cereal-based crops deficient in mineral nutrients is an additional threat to nutritional quality. The present review accounts for the significance of biofortification as a process to enhance the productivity of crops and also an agricultural solution to address the issues of nutritional security. In this endeavor, different innovative and specific biofortification approaches have been discussed for nutrient enrichment of field crops inclu

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Alshuaibi, Aseel, Muhammad Waqas Arshad, and Mohammed Maayah. "A Hybrid Genetic Algorithm and Hidden Markov Model-Based Hashing Technique for Robust Data Security." Journal of Cyber Security and Risk Auditing 2025, no. 3 (2025): 42–56. https://doi.org/10.63180/jcsra.thestap.2025.3.6.

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The growing dependence on technology to store, process, and transmit data across interconnected systems has significantly elevated the need for robust data security. Modern computer systems emphasize the critical principles of authentication and data integrity. With the rise in cyber threats, the importance of securing data transactions against unauthorized or unintentional modifications has become more apparent than ever. As computers continue to play an increasingly vital role in daily operations, managing and safeguarding data alterations is essential. To address these challenges, businesse

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Fukuda, Yosuke, Kaho Akimoto, Tetsuya Homma, et al. "Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach." Journal of Clinical Medicine 9, no. 8 (2020): 2623. http://dx.doi.org/10.3390/jcm9082623.

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The prevalence of asthma has increased worldwide. Asthma exacerbations triggered by upper respiratory tract viral infections remain a major clinical problem and account for hospital admissions and time lost from work. Virus-induced asthma exacerbations cause airway inflammation, resulting in worsening asthma and deterioration in the patients’ quality of life, which may require systemic corticosteroid therapy. Despite recent advances in understanding the cellular and molecular mechanisms underlying asthma exacerbations, current therapeutic modalities are inadequate for complete prevention and t

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Quaratino, S., G. Murison, R. E. Knyba, A. Verhoef, and M. Londei. "Human CD4- CD8- alpha beta+ T cells express a functional T cell receptor and can be activated by superantigens." Journal of Immunology 147, no. 10 (1991): 3319–23. http://dx.doi.org/10.4049/jimmunol.147.10.3319.

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Abstract The CD4 and CD8 molecules play an important role in the stimulation of T cells and in the process of thymic education. Most mature T cells express the alpha beta TCR and either CD4 or CD8; however, there is a small population of alpha beta+ TCR T cells that lack both CD4 and CD8. Little is known of the biology of the CD4- CD8- (double-negative) alpha beta+ TCR T cells or the nature of the Ag to which they may respond. These cells not only represent a novel population of T cells but also provide useful biologic tools to study the roles that CD4 and CD8 play in T cell activation. In thi

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Md. Zubair Al Mahmud. "From Silence to Speech: A Study of Shashi Deshpande’s That Long Silence." Creative Launcher 7, no. 5 (2022): 86–99. http://dx.doi.org/10.53032/tcl.2022.7.5.07.

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In That Long Silence, Deshpande portrays the life of Jaya, an educated, married writer. As a writer, she should be able to use her thinking and analytical skills to show the problems and contradictions in society in her writing. However, this does not happen for several reasons. She has to surrender to family and societal pressures. Not being able to say or write what she feels like saying or writing, she is forced to write what patriarchal society wants to read or hear. Even though she is educated, she remains silent against the injustices that have befallen her. Not only Jaya but also the ot

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Babita and Krishna Chaudhary Dr. "Existential Dilemmas and Patriarchal Oppression: Female Perspectives in Anuradha Roy's An Atlas of Impossible Longing." Sarcouncil Journal of Education and Sociology 4, no. 1 (2025): 6–11. https://doi.org/10.5281/zenodo.14796131.

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Women have internalized their subjugation, often perceiving suffering at the hands of men as their inevitable fate. Their existence is often reduced to fulfilling prescribed roles—as mothers, wives, daughters, or sisters—defined solely by duties and responsibilities imposed by societal norms. Within this framework, women experience a profound loss of individual identity, their personhood overshadowed by the roles they are expected to play. The roots of patriarchy run so deep that dismantling it is a monumental task, one that will require years of collective effort. However, literat

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Geiger, S., S. Gillner, and H. A. Mallot. "Global versus Local Cues for Route Finding in Virtual Environments." Perception 26, no. 1_suppl (1997): 155. http://dx.doi.org/10.1068/v970326.

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Motivated by the results of Gillner and Mallot (1996 Perception25 Supplement, 93) implying that local views are basic elements for a spatial representation, we studied the role of global versus local landmarks using a route-finding task. Our hypotheses were: (i) A global navigation strategy relying on allocentric movement decisions is used, eg “go from this place towards the chapel on the hill”, or (ii) a local navigation strategy based on view—movement associations is used, eg “at the red building go right”. We performed an experiment in a computer graphics town based on a hexagonal grid stru

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Anwer, Qurat ul Ain, and Amna Zahid Chaudhary. "Intersectional Experiences of Rural Women: Analyzing Impact of Gender and Class in Aysha Baqir’s Beyond the Fields." Bulletin of Business and Economics (BBE) 13, no. 2 (2024): 215–25. http://dx.doi.org/10.61506/01.00318.

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The present study aims to analyze the impact of gender and class on rural women. The study focuses on intersectional experiences of female characters. In Beyond the Fields (2019), Baqir reveals how multiple layers of oppression intersect and shape identities of female characters and how these females, Zara, Tara, and Amma, resist and navigate the situations. The purpose of this research is to investigate the various struggles, self-determination, and fortitude demonstrated by rural women in the novel. The present study is descriptive in nature. Close reading and text-based analysis methods are

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Herbrechter, Robin, Nadine Hube, Raoul Buchholz, and Andreas Reiner. "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data." Cellular and Molecular Life Sciences 78, no. 14 (2021): 5605–30. http://dx.doi.org/10.1007/s00018-021-03865-z.

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AbstractIonotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR diversity and to provide context-dependent regulation. Earlier work on isoform identification has focused on the analysis of cloned transcripts, mostly from rodents. We here set out to obtain a systematic overview of iGluR splicing and editing in human brain based on RNA-Seq data. Using data from two large-scale transcriptome studies, we established a workflow for the de novo identification and quantificatio

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Saxena, Sanjai, Laurent Dufossé, Sunil K. Deshmukh, Hemraj Chhipa, and Manish Kumar Gupta. "Endophytic Fungi: A Treasure Trove of Antifungal Metabolites." Microorganisms 12, no. 9 (2024): 1903. http://dx.doi.org/10.3390/microorganisms12091903.

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Emerging and reemerging fungal infections are very common in nosocomial and non-nosocomial settings in people having poor immunogenic profiles either due to hematopoietic stem cell transplants or are using immunomodulators to treat chronic inflammatory disease or autoimmune disorders, undergoing cancer therapy or suffering from an immune weakening disease like HIV. The refractory behavior of opportunistic fungi has necessitated the discovery of unconventional antifungals. The emergence of black fungus infection during COVID-19 also triggered the antifungal discovery program. Natural products a

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Lanfranco, Fabio, Jörg Gromoll, Sigrid von Eckardstein, Eva M. Herding, Eberhard Nieschlag, and Manuela Simoni. "Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism." European Journal of Endocrinology 153, no. 6 (2005): 845–52. http://dx.doi.org/10.1530/eje.1.02031.

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Objective: To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH). Methods: In a retrospective study we analyzed the GnRHR and the GPR54 genes of 45 IHH patients and 50 controls. Genomic DNA was amplified by PCR to obtain partially overlapping amplicons encompassing the exon–intron boundaries of the GnRHR and GPR54 genes and analyzed by single-stranded conformation polymorphism gel electrophoresis and/or DNA sequencing. Results: One heterozy

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Vincent, I. E., C. P. Carrasco, B. Herrmann, et al. "Dendritic Cells Harbor Infectious Porcine CircovirusType 2 in the Absence of Apparent Cell Modulation or Replication of theVirus." Journal of Virology 77, no. 24 (2003): 13288–300. http://dx.doi.org/10.1128/jvi.77.24.13288-13300.2003.

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ABSTRACT Dendritic cells (DCs) play crucial roles in innate and adaptive immune responses, rendering them critical targets for virus infections. Porcine circovirus type 2 (PCV2) is associated with the development of postweaning multisystemic wasting syndrome (PMWS) in piglets. We demonstrate here that 80 to 90% of monocyte-derived and bone marrow-derived DCs interact with PCV2 similar to the early stages of an infection. There was no evidence for virus replication, but the virus did persist in DCs without loss of infectivity nor the induction of cell death. This could reflect an abortive infec

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Wongsantichon, Jantana, and Albert J. Ketterman. "An intersubunit lock-and-key ‘Clasp’ motif in the dimer interface of Delta class glutathione transferase." Biochemical Journal 394, no. 1 (2006): 135–44. http://dx.doi.org/10.1042/bj20050915.

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Structural investigations of a GST (glutathione transferase), adGSTD4-4, from the malaria vector Anopheles dirus show a novel lock-and-key ‘Clasp’ motif in the dimer interface of the Delta class enzyme. This motif also appears to be highly conserved across several insect GST classes, but differs from a previously reported mammalian lock-and-key motif. The aromatic ‘key’ residue not only inserts into a hydrophobic pocket, the ‘lock’, of the neighbouring subunit, but also acts as part of the ‘lock’ for the other subunit ‘key’. The ‘key’ residues from both subunits show aromatic ring stacking wit

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La Salvia, Sabrina, Luca Musante, Joanne Lannigan, Joseph Christopher Gigliotti, Thu H. Le, and Uta Erdbrügger. "T cell-derived extracellular vesicles are elevated in essential HTN." American Journal of Physiology-Renal Physiology 319, no. 5 (2020): F868—F875. http://dx.doi.org/10.1152/ajprenal.00433.2020.

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Extracellular vesicles (EVs) are novel mediators of cell-to-cell communication and appear to mediate the pathogenesis of hypertension (HTN). However, the mechanisms underlying the involvement of EVs in HTN remain unclear. The adaptive and innate immune systems play an important role affecting the kidney and vasculature in animal models of HTN. Evolving evidence shows that immune cell-derived EVs can modulate the immune system in a paracrine fashion and therefore may mediate the effects of inflammation in the pathogenesis of HTN. Therefore, we aimed to understand if specific subtypes of leukocy

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Sun, Zhengrong, Gaowei Ren, Xin Cui, Weiqiang Zhou, Chao Liu, and Qiang Ruan. "Genetic Diversity of HPV-16E6,E7, andL1Genes in Women With Cervical Lesions in Liaoning Province, China." International Journal of Gynecologic Cancer 21, no. 3 (2011): 551–58. http://dx.doi.org/10.1097/igc.0b013e3182112023.

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IntroductionHigh-risk human papillomaviruses (HPVs) play a cardinal role in the etiology of cervical cancer. The most prevalent type, HPV-16, shows intratypic sequence variants that are known to differ in oncogenic potential and geographic distribution. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV-16 are associated with risk of viral persistence and progression.MethodsThis study was designed to analyze sequence variations inE6,E7, andL1genes of HPV-16 in patients with cervical lesion to identify the most prevalent and novel HPV-16 variants in northern China.ResultsOur

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Hu, Guangzhen, Thomas E. Witzig, and Mamta Gupta. "A Novel STAT3 mutation Associated with Diffuse Large B Cell Lymphoma Deregulates STAT3 Signaling." Blood 120, no. 21 (2012): 2690. http://dx.doi.org/10.1182/blood.v120.21.2690.2690.

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Abstract Abstract 2690 Diffuse large B cell lymphoma (DLBCL) is the most common type of adult non-Hodgkin lymphoma. Aberrant gene expression and mutations are involved in the pathogenesis of DLBCL and may have prognostic and therapeutic relevance. We have shown that STAT3 (by immunohistochemistry) is constitutively activated in approximately 50% of new untreated DLBCL cases. To investigate whether genetic mutations play a role in the activation of JAK2/STAT3 signaling pathway in DLBCL, we sequenced the coding regions of the JAK2 gene and found no novel missense mutations. Since we did not find

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Mahgoub, Bayan, Weikun Xiao, and Reginald Hill. "Abstract 2349: Investigating the effect of ECM stiffness on macrophage-derived exosome secretion and PDAC organoid progression." Cancer Research 83, no. 7_Supplement (2023): 2349. http://dx.doi.org/10.1158/1538-7445.am2023-2349.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of only 11%. Current treatments that mostly target the cancer cells themselves, have not been able to significantly improve survival rates, meaning there is an urgent need for novel therapies. PDAC is unique among solid tumors because it exhibits extensive desmoplasia that is characterized by an abundance of extracellular matrix (ECM) components. In recent years, an increasing body of work has shown that cancer tissue is stiffer than normal tissue by a factor of 3 or more. This change in ECM stiffness has been shown to

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Wan, Youzhong, Michael S. Lawrence, Lili Wang, et al. "Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1." Blood 118, no. 21 (2011): 463. http://dx.doi.org/10.1182/blood.v118.21.463.463.

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Abstract Abstract 463 The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering new therapeutic targets and biomarkers. We therefore performed DNA sequencing of 91 CLL samples with matched germline, consisting of 88 exomes and 3 genomes. Samples were collected from patients displaying a range of characteristics representing the broad clinical spectrum of CLL. Li

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Murray, Katherine C., Marilee J. Stephens, Michelle Rank, Jessica D'Amico, Monica A. Gorassini, and David J. Bennett. "Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors." Journal of Neurophysiology 106, no. 2 (2011): 925–43. http://dx.doi.org/10.1152/jn.01011.2010.

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Sensory afferent transmission and associated spinal reflexes are normally inhibited by serotonin (5-HT) derived from the brain stem. Spinal cord injury (SCI) that eliminates this 5-HT innervation leads to a disinhibition of sensory transmission and a consequent emergence of unusually long polysynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons. These EPSPs play a critical role in triggering long polysynaptic reflexes (LPRs) that initiate muscles spasms. In the present study we examined which 5-HT receptors modulate the EPSPs and whether these receptors adapt to a loss of 5-HT af

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Smith, Victoria, Dana Maslovat, Neil M. Drummond, Joëlle Hajj, Alexandra Leguerrier, and Anthony N. Carlsen. "High-intensity transcranial magnetic stimulation reveals differential cortical contributions to prepared responses." Journal of Neurophysiology 121, no. 5 (2019): 1809–21. http://dx.doi.org/10.1152/jn.00510.2018.

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Corticospinal output pathways have typically been considered to be the primary driver for voluntary movements of the hand/forearm; however, more recently, reticulospinal drive has also been implicated in the production of these movements. Although both pathways may play a role, the reticulospinal tract is thought to have stronger connections to flexor muscles than to extensors. Similarly, movements involuntarily triggered via a startling acoustic stimulus (SAS) are believed to receive greater reticular input than voluntary movements. To investigate a differential role of reticulospinal drive d

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Liu, Wenju, Chao Du, Liangkang Nan, et al. "Influence of Estrus on Dairy Cow Milk Exosomal miRNAs and Their Role in Hormone Secretion by Granulosa Cells." International Journal of Molecular Sciences 24, no. 11 (2023): 9608. http://dx.doi.org/10.3390/ijms24119608.

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Estrus is crucial for cow fertility in modern dairy farms, but almost 50% of cows do not show the behavioral signs of estrus due to silent estrus and lack of suitable and high-accuracy methods to detect estrus. MiRNA and exosomes play essential roles in reproductive function and may be developed as novel biomarkers in estrus detection. Thus, we analyzed the miRNA expression patterns in milk exosomes during estrus and the effect of milk exosomes on hormone secretion in cultured bovine granulosa cells in vitro. We found that the number of exosomes and the exosome protein concentration in estrous

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