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Dissertations / Theses on the topic 'Pleiotropy'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Rodríguez, Pérez Juan Antonio 1985. "Testing two evolutionary theories of ageing by using public genome-wide data." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/565860.

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Old age comes coupled with frailty and disease and, thus, the ageing of the World’s population have spurred the interest on the causes and mechanisms of senescence. Senescence has long been a mystery, with no single universally accepted theory accounting for its ultimate evolutionary causes (if indeed these causes exist). Perhaps two of the most popular evolutionary explanations proposed so far are the Mutation Accumulation Theory of Senescence proposed by Peter Medawar in 1951 and the Antagonistic Pleiotropy Theory of Senescence, suggested by George C. Williams in 1957. The large amount of da

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2

Trochet, Holly. "Simple Bayesian approaches to modelling pleiotropy in genetic association data." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:a1e3d606-ef39-4ef7-981e-088d6703c04f.

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Genome-wide association studies (GWAS) have become one of the most common types of genetic studies, due to their success at finding markers associated with diseases and other traits of interest. With thousands of these studies performed in the last decade, a variety of methods have been developed to meta-analyze their results to search for variants that affect multiple traits. This thesis introduces one such method, based on approximate Bayes factors (ABFs), which relies only on effect size estimates and standard errors from GWAS. Through application to simulated data as well as three differen

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3

Giaimo, S. "THE PLEIOTROPY THEORY OF AGEING: CONCEPTUAL, METHODOLOGICAL AND EMPIRICAL ISSUES." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155520.

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This thesis discusses the pleiotropy theory of ageing in evolutionary biology in some of its most important aspects. In short, the theory says that natural selection fosters the early-life survival and reproductive performances of an organism even if this would necessarily impose a cost on later-life survivorship and reproduction thereby leading to the evolution of that peculiar pattern of age-correlated decline in biological functioning that characterizes ageing. The theory predicts that the level of external/environmental mortality should positively correlate with the rate of ageing in a pop

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4

Xinmin, Li. "Experimental studies of pleiotropy at the Adh locus of Drosophila melanogaster." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276173.

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5

Butson, Melissa B. "Implications of Pleiotropy for Clinical Genetic Testing: Assessing the Patient Perspective." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1333112935.

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6

Alzoubi, Deya [Verfasser]. "Pleiotropy and Epistasis in constraint-based models of microbial metabolism / Deya Alzoubi." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1188017624/34.

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7

Ramkumar, Charusheila. "Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/634.

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In response to telomere shortening, oxidative stress, DNA damage or aberrant activation of oncogenes, normal somatic cells exit the cell cycle and enter an irreversible growth arrest termed senescence. The limited proliferative capacity imposed by senescence on cells impedes the accumulation of mutations necessary for tumorigenesis and prevents proliferation of cells at risk of neoplastic transformation. Opposite to the tumor suppressor function, accumulation of senescent cells in adult organisms is thought to contribute to aging by depleting the renewal capacity of tissues and stem/progenitor

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8

Brunel, Montaner Helena. "Genetic association analysis of complex diseases through information theoretic metrics and linear pleiotropy." Doctoral thesis, Universitat Politècnica de Catalunya, 2013. http://hdl.handle.net/10803/134362.

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The main goal of this thesis was to help in the identification of genetic variants that are responsible for complex traits, combining both linear and nonlinear approaches. First, two one-locus approaches were proposed. The first one defined and characterized a novel nonlinear test of genetic association, based on the mutual information measure. This test takes into account the genetic structure of the population. It was applied to the GAW17 dataset and compared to the standard linear test of association. Since the solution of the GAW17 simulation model was known, this study served to characte

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9

Utsunomiya, Yuri Tani. "Sobre a origem e dispersão da mutação do gene PLAG1 em bovinos." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152438.

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MARULLO, Letizia. "Dissection of pleiotropic effects in genome-wide association studies of phenotypes related to cardiometabolic health." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2388968.

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In the past seven years, Genome-Wide Association Studies (GWAS) have identified hundreds of variants associated with cardiometabolic quantitative traits and diseases. Many genetic loci appear to harbour variants associated with multiple phenotypes (cross-phenotype associations, CP). CP associations highlight that phenotypes may share common underlying genetic mechanisms that might, or might not, be consistent with epidemiological expectations and, therefore, add complexity to the relationships between human phenotypes. Pleiotropy occurs when the same genetic causal element affects more than o

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11

Cisneros, Caballero Angel Fernando, and Caballero Angel Fernando Cisneros. "The role of structural pleiotropy in the retention of protein complexes after gene duplication." Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/37529.

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La duplication de gènes est l’un des plus importants mécanismes évolutifs pour la génération de diversité fonctionelle. Lorsqu’un gène est dupliqué, la nouvelle copie partage toutes ses fonctions avec la copie ancestrale car elles encodent pour des protéines identiques. Donc, les deux protéines, appelées paralogues, auront le même réseau d’interactions physiques protéine-protéine. Cependant, dans le cas de la duplication des gènes qui codent des protéines qui interagissent avec elles-mêmes (homomères), la nouvelle protéine interagira aussi avec la copie ancestrale, ce qui introduit une nouvell

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Duarte, Nubia Esteban. "Análise multivariada no mapeamento genético de traços quantitativos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-01032013-184306/.

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Em pesquisa Genômica é de grande interesse o mapeamento de genes que controlam traços ou fenótipos quantitativos. Metodologias estatsticas para identicar genes que tenham efeitos sobre um unico traço são bem conhecidas na literatura e têm sido exaustivamente aplicadas no mapeamento genético de muitas doenças. Porem, na pratica, diferentes traços são correlacionados, como é o caso de hipertensão e obesidade, possivelmente, devido a aço de genes comuns envolvidos na sua regulação. Nestes casos, por meio de tecnicas estatísticas multivariadas, que exploram a estrutura de covariância entre os traç

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13

Rostant, Wayne Geoffrey. "Sex-specific effects of DDT resistance in flies." Thesis, University of Exeter, 2012. http://hdl.handle.net/10871/10521.

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In D. melanogaster, resistance to DDT is conferred by the upregulation of a cytochrome P450 enzyme, CYP6G1. Resistant flies have tandemly duplicated Cyp6g1 alleles that possess the LTR (Long Terminal Repeat) of an Accord retrotransposon inserted in the cis-regulatory region, 291bp upstream of the transcription start site. This DDT resistance allele (DDT-R) has been shown to have pleiotropic fitness benefits for female flies in at least one genetic background and with evidence of sexually antagonistic selection at this locus. In this thesis, I first review the role of transposable elements in c

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14

Chen, Daidi. "Genetic studies on pleiotropic polyoxin resistant mutants of Bipolaris maydis." Kyoto University, 2018. http://hdl.handle.net/2433/232359.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21158号<br>農博第2284号<br>新制||農||1060(附属図書館)<br>学位論文||H30||N5132(農学部図書室)<br>京都大学大学院農学研究科地域環境科学専攻<br>(主査)教授田中千尋, 教授本田与一, 教授宮川恒<br>学位規則第4条第1項該当

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15

ZEH, DAVID WAYNE. "ECOLOGICAL FACTORS, PLEIOTROPY, AND THE EVOLUTION OF SEXUAL DIMORPHISM IN CHERNETID PSEUDOSCORPIONS (PHORESY, QUANTITATIVE GENETICS, SEXUAL SELECTION)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183995.

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The determinants of sexual dimorphism in a family of false scorpions (Pseudoscorpionida, Chernetidae) were investigated experimentally and with a literature analysis of comparative morphometric and habitat data. Species vary in the extent to which males and females differ in size of the conspicuous, prehensile pedipalps. Patterns within the Chernetidae suggest that dimorphism is a highly variable condition, relatively unconstrained by phylogenetic influences. The evolution of species with enlarged male pedipalps appears to be associated with a change from nonpairing to pairing sperm transfer b

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Rocha, Felipe Bastos 1981. "Plasticidade fenotípica em Drosophila mediopunctata : não-linearidade e correlações com valor médio." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316966.

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Orientador: Louis Bernard Klaczko<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-22T03:22:48Z (GMT). No. of bitstreams: 1 Rocha_FelipeBastos_D.pdf: 4246569 bytes, checksum: 8297db94661890abb9ddc71ef0280318 (MD5) Previous issue date: 2013<br>Resumo: Apesar de descrever a dinâmica populacional da variação genética, a teoria da genética de populações não descreve como a interação entre genótipos e os ambientes onde estes se desenvolvem gera distribuições fenotípicas. As normas de reação representam uma possível estratégia p

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Sikkink, Kristin. "Experimental Evolution of Phenotypic Plasticity for Stress Resistance in the Nematode Caenorhabditis remanei." Thesis, University of Oregon, 2014. http://hdl.handle.net/1794/18425.

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Many organisms can acclimate to new environments through phenotypic plasticity, a complex trait that can be heritable, be subject to selection, and evolve. However, the rate and genetic basis of plasticity evolution remain largely unknown. Experimentally evolved populations of the nematode Caenorhabditis remanei were created by selecting for stress resistance under different environmental conditions. This resource was used to address key questions about how phenotypic plasticity evolves and what the genetic basis of plasticity is. Here, I highlight ways in which a fuller understanding of the e

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18

Sztepanacz, Jacqueline L. P. "The Genetic Limits to Trait Evolution for a Suite of Sexually Selected Male Cuticular Hydrocarbons in Drosophila Serrata." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20385.

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Directional selection is prevalent in nature yet phenotypes tend to remain relatively constant, suggesting a limit to trait evolution. The genetic basis of evolutionary limits in unmanipulated populations, however, is generally not known. Given widespread pleiotropy, opposing selection on a focal trait may arise from the effects of the underlying alleles on other fitness components, generating net stabilizing selection on trait genetic variance and thus limiting evolution. Here, I look for the signature of stabilizing selection for a suite of cuticular hydrocarbons (CHCs) in Drosophila serrata

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19

Pinto, Luis Fernando Batista. "Ocorrência de interações QTL x Sexo, de epistasias e de QTLs pleiotrópicos em aves (Gallus gallus)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-15062007-093204/.

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Este estudo teve por objetivo mapear QTLs para características de desempenho e de carcaça em Gallus gallus . Foram estudadas 350 aves F2 oriundas de um cruzamento, na primeira geração, de machos de corte da linhagem TT com fêmeas de postura da linhagem CC. O peso vivo com 1, 35 e 42 dias de idade; o ganho de peso, o consumo de ração e a conversão alimentar de 35 a 41 dias de idade; os pesos dos pulmões, fígado, coração, moela, peito, coxas (peso de coxas e sobre-coxas), carcaça (sem vísceras, pés e cabeça), carcaça residual (peso da carcaça sem peito, asas e coxas), asas, cabeça, pés e gordura

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20

Bloss, Cinnamon Sue. "APOE genotype and cognitive functioning in school-aged children a risk factor for decreased cognitive reserve or an example of antagonistic pleiotropy? /." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3258531.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2007.<br>Title from first page of PDF file (viewed May 30, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 116-127).

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21

Andrade, Melina Teixeira. "Epistasia e parâmentros genéticos em ambientes com e sem estresse hídrico em milho." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-17082017-153104/.

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Em estudos recentes, a epistasia tem sido detectada no controle genético de caracteres quantitativos em diversas espécies. Dado o grande número de locos controlando um único caráter, é evidente que ocorram interações inter-alélicas, além de pleiotropia, que resulta do controle de mais de um caráter por um mesmo loco. Também tem sido reportada a presença de epistasia pleiotrópica em animais, que basicamente resulta do efeito da epistasia sobre locos pleiotrópicos ou sobre múltiplos caracteres, afetando a correlação genética entre esses. Desse modo, o objetivo desta pesquisa foi a análise genéti

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22

Arora, Gaurav S. "Comparative analysis of apoptotic function between humans, chimpanzees and macaques." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44914.

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Humans and chimpanzees differ in a number of phenotypic traits chief among them being a larger sized human brain and an increased propensity for cancer in humans. Apoptosis or programmed cell death plays a role during brain development and disease progression to cancer. Results from my study, based on gene expression analysis, suggest that the apoptotic function may be generally reduced in humans relative to chimpanzees. In this thesis, I test the hypothesis that the apoptotic function is generally reduced in humans relative to chimpanzees by gene expression and experimental data. The experime

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23

Simmons, Michael. "Identifying Genetic Pleiotropy through a Literature-wide Association Study (LitWAS) and a Phenotype Association Study (PheWAS) in the Age-related Eye Disease Study 2 (AREDS2)." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623630.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Genetic association studies simplify genotype‐phenotype relationship investigation by considering only the presence of a given polymorphism and the presence or absence of a given downstream phenotype. Although such associations do not indicate causation, collections of phenotypes sharing association with a single genetic polymorphism may provide valuable mechanistic insights. In this thesis we explore such genetic pleiotropy with Deep

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Aldasoro, Alex-Ander. "Post-GWAS Investigations for discovering pleiotropic gene effects in cardiovascular diseases." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0247/document.

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Les maladies cardiovasculaires (MCV) sont d’une étiologie complexe et elles sont soumises à de nombreux facteurs environnementaux ainsi que génétiques. Malgré les succès obtenus, pendant la dernière décennie, et pour réduire la mortalité CV il est nécessaire l’identification de nouveaux biomarqueurs en utilisant des approches différentes. Cette thèse propose une approche intégrative pour découvrir de nouvelles associations génétiques associés avec les MCV. Nous avons d’abord réuni les résultats existants grâce à des GWAS précédents, puis nous avons recherché la pléiotropie de ces gènes et nous

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Peltier, Emilien. "Étude des causes génétiques de la plasticité phénotypique par une approche de cartographie de QTLs : cas de la levure oenologique Saccharomyces cerevisiae." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0945/document.

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La levure S. cerevisiae est la seule espèce capable de terminer la fermentation alcoolique du jus de raisin qui est l’étape principale de la vinification. A cause de la forte variabilité technologique retrouvée chez cette espèce, des travaux de sélection sont réalisés dans le but d’utiliser des levains performants pour l’industrie. Ces souches montrent des différences importantes à la fois dans leurs cinétiques fermentaires et leur bilans en métabolites, ce qui impacte la qualité des vins. La réponse phénotypique des levures varie également de manière considérable et non homogène face aux vari

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Broc, Camilo. "Variable selection for data aggregated from different sources with group of variable structure." Thesis, Pau, 2019. http://www.theses.fr/2019PAUU3048.

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Durant les dernières décennies, la quantité de données disponibles en génétique a consi-dérablement augmenté. D’une part, une amélioration des technologies de séquençage demolécules a permis de réduire fortement le coût d’extraction du génome humain. D’autrepart, des consortiums internationaux d’institutions ont permis la mise en commun de lacollecte de données sur de larges populations. Cette quantité de données nous permetd’espérer mieux comprendre les mécanismes régissant le fonctionnement de nos cellules.Dans ce contexte, l’épidémiologie génétique est un domaine cherchant à déterminer lare

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Sabadin, Priscilla Karen. "Mapeamento de QTL's e base genética da correlação entre caracteres em uma população de milho tropical." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-11072008-163229/.

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Os caracteres quantitativos normalmente têm elevada importância agronômica e econômica, sendo geralmente os mais importantes nos programas de melhoramento das mais diversas espécies, como é o caso do milho (Zea mays L.). Dentre os vários caracteres considerados, destaca-se a produção de grãos e seus componentes. Dessa forma, o objeto de estudo do presente trabalho foi mapear QTL´s relacionados à vários caracteres de importância agronômica, estimar seus efeitos genéticos e entender as causas da correlação genética (pleiotropia ou ligação), em uma população de milho tropical. Para tanto, foi uti

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Potey, Camille. "Intérêt des approches pléiotropes dans l'ischémie cérébrale : modulation pharmacologique par l'atorvastatine." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S014/document.

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L’accident vasculaire cérébral ischémique reste un problème majeur de santé publique, contre lequel l’arsenal thérapeutique reste très limité. L’atorvastatine (AT), utilisée en prévention cardiovasculaire, possède des effets pléiotropes lui conférant un pouvoir protecteur dans l’AVC. Les objectifs de cette thèse étaient d’évaluer et de caractériser les effets neuro- et vasculoprotecteurs de l’AT dans l’ischémie cérébrale, et la part jouée par le récepteur nucléaire PPARα. Des souris C57BL/6J sauvages et KO-PPARα ont été soumises à ischémie-reperfusion (I/R) cérébrale. Elles étaient traitées pa

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Delcourt, Matthieu. "The Quantitative Genetics of Good Genes: Fitness, Male Display, and Female Preference." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20311.

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The ultimate goal of my thesis is to develop a better understanding of the contribution of indirect benefits (i.e. good genes) to the evolution of female mate preferences. It is genetic variance in, and genetic correlations (covariances) among, male sexual displays, female preferences for them, and fitness that in part determine the degree to which females preferring certain male displays over others will gain an indirect benefit by having higher fitness offspring. Recent advances in quantitative genetic theory provide the mathematical means for quantifying the strength of indirect selection f

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Oget, Claire. "Effet pléiotrope de la mutation R96C dans le gène SOCS2 chez la brebis laitière." Thesis, Toulouse, INPT, 2019. http://www.theses.fr/2019INPT0100.

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Les mammites représentent un gros fardeau pour l'industrie laitière en raison de l'altération de la qualité du lait et de l'augmentation du coût de production. En plus des mesures d'hygiène mises en oeuvre, la sélection en faveur d'une plus grande immunité contre les infections mammaires et de la résistance aux mammites est considérée et implémentée dans les programmes d'amélioration de plusieurs races laitières. Cependant,la résistance aux mammites est un caractère complexe dont les bases biologiques de détermination génétique restent peu connues. Depuis une dizaine d'années, le décryptage de

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Eggebrecht, Lisa [Verfasser]. "Oral anticoagulation therapy – Clinical application and pleiotropic effects on the cardiovascular system = Therapie mit oralen Antikoagulanzien - klinische Anwendung und pleiotrope Effekte auf das kardiovaskuläre System / Lisa Eggebrecht." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1214251129/34.

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Kangas-Kontio, T. (Tiia). "Genetic background of HDL-cholesterol and atherosclerosis:linkage and case-control studies in the Northern Finnish population." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295812.

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Abstract Coronary heart disease (CHD), a manifestation of atherosclerosis, is the leading single cause of death in Finland. CHD is affected by numerous genetic and environmental factors, their combined effects and interactions between them. Low HDL-cholesterol (HDL-C) is an independent risk factor for atherosclerosis and the most common dyslipidemia associated with early onset CHD, but the mechanisms regulating HDL-C levels and protecting from atherosclerosis are still not completely understood. Adiponectin is a hormone that is secreted by adipose tissue and has several anti-atherosclerotic ef

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Qi, Qin. "An integrative approach to understanding the fitness cost of rifampicin resistance in Pseudomonas aeruginosa." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6a82bd64-3b3f-444b-b379-62f01f681594.

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Antibiotic resistance in bacteria is acquired through spontaneous chromosomal mutations or horizontal gene transfer. In the absence of antibiotics, resistant mutants generally show reduced fitness due to compromised growth rate, competitive ability and virulence compared to their antibiotic-sensitive ancestors. The focus of my research is to dissect the molecular underpinnings of the variations in the fitness cost of chromosomal antibiotic resistance using a systems-level approach. From an evolutionary perspective, my research aims are to understand how the fitness cost influences adaptation i

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Sharples, Edward John. "Pleiotropic effects of erythropoietin." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2351.

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The haematopoietic growth factor Erythropoietin (EPO) is essential for the survival of erythroid progenitors to maturation and differentiation. It has been recognised that the EPO signalling pathway is also present in other tissues including the brain and vasculature, and is integral to the physiological response to ischaemia. Exogenous EPO was found to improve the outcome in animal models of stroke. The primary aim of this thesis was to examine whether erythropoietin was protective in a model of acute kidney injury, and to determine the mechanism by which EPO exerted this effect. In vitro exp

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Lage, Hermann. "Atypische pleiotrope Zytostatikaresistenz (Multidrug-Resistenz) humaner Tumorzellen." Doctoral thesis, [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963803921.

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MacDonald, Simon T. "Mechanisms of cardiac pleiotrophy in cited 2 dificiency." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490109.

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How can a single gene defect present with a varied phenotype- Cited2 gene deletion in the mouse results in pleiotropic, penetrant and variable cardiovascula malformations, laterality defects, adrenal agenesis, neural tube defects and fused cranial ganglia. CITED2 acts as a transcriptional co-activator, and as transcriptional repressor of PHFIA. Loss of Cited2 has been shown to be associated with increased levels of Vegf-a, a HIFIA target, and reduced levels of the key left-right patteming genes Nodal, Pitxlc, Leftyl in the left lateral piate mesoderm, and Pitx2c in the heart.

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Althof, Eva. "Sekundäre Pflanzenstoffe - Adaptation oder Pleiotropie?" [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-59020.

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Bürstel, Ingmar. "Die pleiotrope Maturation der sauerstofftoleranten [NiFe]-Hydrogenasen aus Ralstonia eutropha." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16730.

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Hydrogenasen sind komplexe Enzyme, die die reversible Oxidation von molekularem Wasserstoff zu Protonen und Elektronen katalysieren. Diese Enzyme erlauben ihrem Wirtsorganismus das Wachstum unter chemolithoautotrophen Bedingungen. Der Modellorganismus Ralstonia eutropha besitzt drei gut charakterisierte Hydrogenasen der [NiFe]-Klasse, die sich durch ihre Sauerstofftoleranz auszeichnen. Ihr aktives Zentrum besteht aus einer komplexen prosthetischen Gruppe, welche aus einem Nickel- und einem Eisenatom besteht. Letzteres koordiniert drei diatomare Liganden, zwei Cyanide und ein CO. Die Synthese d

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Martynoga, Ben. "Foxg1 : a pleiotropic regulator of telencephalic development." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29250.

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This thesis focuses on the role of the forkhead box factor Foxg1 in the development of the vertebrate telencephalon. Mice mutant for <i>Foxg1</i> exhibit multiple telencephalic defects demonstrative of an important pleiotropic role of rFoxg1 in telencephalic organogenesis. Severe hypoplasia of the null mutant telencephalon demonstrates that Foxg1 is required for the regulation of telencephalic growth. Experiments descried in this thesis provide the most systematic study to date of the mechanisms by which Foxg1 regulates this process. Broadly, the results demonstrate that Foxg1 is required to m

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Metz, Jesse de. "Pleiotropic responses to interferon-gamma in humans." [Amsterdam : Amsterdam : Thela-Thesis] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/56816.

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Proefschrift Universiteit van Amsterdam.<br>Ondertitel op omslag: Studies on metabolic, endocrine and immunological effects in healthy subjects and surgical patients. Met lit. opg. - Met samenvatting in het Nederlands.

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Ostrowski, Stephen M. "Pleiotropic mechanisms of statin action in Alzheimer's Disease." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1190669698.

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Ahmed, F. A. W. "Pleiotropic effects of coat-colour mutants in mice." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375647.

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Ostrowski, Stephen M. "Pleiotropic Mechanisms of Statin Action in Alzheimer's Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1190669698.

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WETHERILL, YELENA B. "PLEIOTROPIC EFFECTS OF XENOESTROGEN ACTION IN PROSTATE CANCER." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1109257593.

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Pollini, Daniele. "Pleiotropic effect of MATR3 in pluripotent stem cells." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276211.

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Matrin3 (MATR3) is an RNA binding protein involved in many roles in the nucleus, such as chromatin architecture and gene expression regulation, modulating transcriptional and post-transcriptional processes as RNA splicing and mRNA stabilization. Nevertheless, some functions of MATR3 within the cells are not entirely clear. MATR3 has been associated with Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that damages motor neuron (MN) cells and leads to progressive muscle paralysis and respiratory failure. A better understanding of MATR3 activity within cell physiology could repre

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Pollini, Daniele. "Pleiotropic effect of MATR3 in pluripotent stem cells." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276211.

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Matrin3 (MATR3) is an RNA binding protein involved in many roles in the nucleus, such as chromatin architecture and gene expression regulation, modulating transcriptional and post-transcriptional processes as RNA splicing and mRNA stabilization. Nevertheless, some functions of MATR3 within the cells are not entirely clear. MATR3 has been associated with Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that damages motor neuron (MN) cells and leads to progressive muscle paralysis and respiratory failure. A better understanding of MATR3 activity within cell physiology could repre

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Lage, Hermann [Verfasser], and R. [Gutachter] Osieka. "Atypische pleiotrope Zytostatikaresistenz (Multidrug-Resistenz) humaner Tumorzellen / Hermann Lage ; Gutachter: R. Osieka." Berlin : Humboldt-Universität zu Berlin, 2001. http://d-nb.info/1207623946/34.

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Hillyard, Dianne Zoë. "The pleiotropic effect of statins on immune cell function." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/5379/.

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In this thesis, the pleiotropic effects of statins on the disruption of prenylation and membrane rafts were investigated in immune effector cells. T cells and NK cells were extracted from various groups of patients treated with statins and proliferation and cytotoxicity respectively, measured ex vivo. In a study of patients with cardiovascular disease, a 23% reduction in T cell proliferation and 43% reduction in NK cytotoxicity were observed. In a normal volunteer study where healthy subjects received simvastatin (40mg per day) for 4 weeks, a comparable reduction in T cell proliferation was no

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Lock, Daniel. "The pleiotropic effects of vitamin D promoting bowel health." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/66585/.

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Vitamin D insufficiency is seasonally endemic in populations north of the 40th parallel, and epidemiological data show an association with colorectal cancer risk and prognosis. Molecular mechanisms that underpin the relationship are not well established. Vitamin D status is shown to be associated with age-related silencing of tumour suppressors in colonic stem cells via aberrant DNA methylation, suggesting that insufficiency contributes to transformation. In this text, vitamin D’s ability to promote bowel health via modification of DNA methylation patterns has been investigated. Chronic inflam

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Quintero, Yanes Alex Armando. "Novel pleiotropic regulators of gas vesicle biogenesis in Serratia." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288405.

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Serratia sp. ATCC 39006 (S39006) is known for producing carbapenem and prodiginine antibiotics; 1-carbapen-2-em-3-carboxylic acid (car) and prodigiosin. It displays different motility mechanisms, such as swimming and swarming aided by flagellar rotation and biosurfactant production. In addition, S39006 produces gas vesicles to float in aqueous environments and enable colonization of air-liquid interfaces. Gas vesicles are thought to be constructed solely from proteins expressed from a gene cluster composed of two contiguous operons, gvpA1-gvpY and gvrA-gvrC. Prior to this study, three cognate

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