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Journal articles on the topic 'Pleomorphic Adenomas'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bhandari, Anuja, Shovana Karki, and Geeta Sayami. "Carcinoma ex pleomorphic adenoma of the parotid gland with cardiac metastasis." Journal of Pathology of Nepal 8, no. 2 (2018): 1422–24. http://dx.doi.org/10.3126/jpn.v8i2.20899.

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Pleomorphic adenomas are the most common neoplasms of the major salivary glands. They are also known as benign mixed tumors because of the presence of both epithelial and mesenchymal elements. In parotid gland, approximately 65%-75% of tumors are pleomorphic adenomas. In parotid gland, usually it occur lateral to the plane of facial nerve. They present in middle aged patients as well defined, solitary, painless mass and are slow growing tumors. Few subset of tumors may undergo malignant transformation.Carcinoma ex pleomorphic adenoma is a rare and aggressive malignancy that arises from primary

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2

Joshi, Sushant, HS Bhuie, and Navneet Mathur. "Pleomorphic Adenoma of Nasal Cavity: A Rare Case Report." An International Journal Clinical Rhinology 7, no. 2 (2014): 67–69. http://dx.doi.org/10.5005/jp-journals-10013-1198.

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ABSTRACT Pleomorphic adenomas are most common benign tumor of the major salivary gland, mainly found in parotid gland. Pleomorphic adenomas may also occur in the minor salivary glands of the hard and soft palate. Few cases are also diagnosed in various parts of pharynx and larynx. Intranasal pleomorphic adenomas can arise either from septum or lateral nasal wall. They are very rare entity and occasionally misdiagnosed due to their atypical histopathology. We present a rare case of pleomorphic adenoma diagnosed in middle-aged female originating from lateral wall of right nasal cavity. How to ci

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3

Nishimura, Toshiro, Mitsuru Furukawa, Ei Kawahara, and Atsuo Miwa. "Differential diagnosis of pleomorphic adenoma by immunohistochemical means." Journal of Laryngology & Otology 105, no. 12 (1991): 1057–60. http://dx.doi.org/10.1017/s0022215100118183.

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AbstractImmunohistochemical study of major salivary gland tumours was performed on 60 pleomorphic adenomas, five basal cell adenomas and 10 adenoid cystic carcinomas to determine the diagnostic value of each antigen. Immunoreactivity examined were intermediate filaments (keratin, vimentin, desmin and glial fibrillary acidic protein [GFAP]) and related substances (actin, S-100 protein and secretory component). In pleomorphic adenomas, there was positive immunoreactivity for GFAP which was not observed in normal tissue or other neoplastic tissues. Immunoreactivity of GFAP was closely related to

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4

Sohala, Karpal Singh. "Retrospective Analysis of Histopathological Reports of Salivary Gland Pleomorphic Adenomas in Tanzania." East African Health Research Journal 8, no. 2 (2024): 195–99. https://doi.org/10.24248/eahrj.v8i2.781.

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Background: Pleomorphic adenoma (PA) is the most common benign tumor representing about 80% of all salivary gland tumors. Despite this, there is limited documentation of the demographic information and pattern of PA in Tanzania. This study retrospectively determines the demographic information and the pattern of presentation of pleomorphic adenomas of the salivary gland among patients managed at a tertiary hospital in Tanzania. Methods: This was a retrospective study of histological results of salivary gland pleomorphic adenoma diagnosed between 2016 and 2021. The information gathered included

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Mouzali, Amina, Samia Lameche, Assia Slimani, and Omar Zemirli. "Pleomorphic Adenoma of the Ala Nasi: A Case Report." Clinical Medicine Insights: Ear, Nose and Throat 12 (January 2019): 117955061988656. http://dx.doi.org/10.1177/1179550619886561.

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Objectives: Pleomorphic adenomas are benign tumors that rarely involve nonsalivary glands. We report an uncommon case of ala nasi pleomorphic adenoma. We discuss the clinical and histopathologic characteristics, and review the literature on nasal pleomorphic adenoma. Method: A 20-year-old man presented with a painless slow growing lobulated mass located on the right ala nasi extending into the nasal vestibule. Results: Complete surgical excision was performed. Histologic examination found a mixed cellular component: epithelial and myoepithelial cells with chondromyxoid stroma. This was consist

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6

Das, Sanjoy, Niaz Ahmed, Mohammed Main Uddin, Mohammad Hossain Bhuiyan, Manjur E. Mahmud, and Mohammed Kamal Uddin. "Role of Fine Needle Aspiration Cytology in the Diagnosis Of Pleomorphic Adenoma With Histological Correlation." Journal of Chittagong Medical College Teachers' Association 30, no. 1 (2019): 56–60. http://dx.doi.org/10.3329/jcmcta.v30i1.62569.

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Background: Fine Needle Aspiration Cytology (FNAC) has been widely accepted as an accurate and minimally invasive diagnostic procedure in the investigations of salivary gland masses. The aim of this study was to determine the accuracy of FNAC in the diagnosis of pleomorphic adenoma. Materials and methods: A cross sectional comparative study was carried out on a total of 28 patients with salivary gland swellings who underwent preoperative FNA examination. After surgical excision of tumours, all FNAC findings were subsequently verified with histopathological examination. All the necessary and re

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DeRoche, Tom C., Aaron P. Hoschar, and Jennifer L. Hunt. "Immunohistochemical Evaluation of Androgen Receptor, HER-2/neu, and p53 in Benign Pleomorphic Adenomas." Archives of Pathology & Laboratory Medicine 132, no. 12 (2008): 1907–11. http://dx.doi.org/10.5858/132.12.1907.

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Abstract Context.—Immunohistochemical stains for androgen receptor (AR), HER-2/neu, and p53 are used as diagnostic markers associated with malignancy in several histologic types of salivary gland tumors. These markers may be useful in differentiating pleomorphic adenoma with cytologic atypia from intracapsular carcinoma ex pleomorphic adenoma (CXPA), as these tumors are often difficult to distinguish on the basis of morphology alone. Objective.—To determine whether AR, HER-2/neu, and p53 expression can be seen in entirely benign pleomorphic adenomas. Design.—Androgen receptor, HER-2/neu, and p

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8

Paudyal, P., K. Pande, A. Pradhan, R. Shah, P. Upadhyaya, and S. Thapa. "Pleomorphic adenoma of nasal septum: A case report." Journal of Pathology of Nepal 7, no. 1 (2017): 1133–35. http://dx.doi.org/10.3126/jpn.v7i1.16947.

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Pleomorphic adenomas are the most common benign tumor of the major salivary glands. Other rare sites for the occurrence of pleomorphic adenoma have been described in the larynx, pharynx, nasal cavity, lacrimal glands and trachea. We report here a case of intranasal pleomorphic adenoma arising from the nasal septum causing nasal obstruction which was clinically diagnosed as papilloma. Histopathology confirmed the diagnosis of pleomorphic adenoma.

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9

Lo, Stephen, Silvana Di Palma, Hafsa Yusuf, and Andrew W. McCombe. "Constitutive (HO-2) and inducible (HO-1) haem oxygenase in pleomorphic adenomas of the human parotid: an immunocytochemical study." Journal of Laryngology & Otology 119, no. 3 (2005): 179–83. http://dx.doi.org/10.1258/0022215053561567.

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This study examines the expression HO-1 and HO-2 isozymes in human parotid pleomorphic adenomas. They are members of the heat shock protein family, and are thought to play a role in the regulation of tumoral blood flow. Immunocytochemistry using antibodies specific for HO-1 and HO-2 were undertaken in 12 pleomorphic adenoma specimens, all sections of which contained adjacent normal salivary tissue. Normal salivary gland acini and ducts displayed significantly stronger immunoreactivity for HO-2 compared to tumour cells (p < 0.001). Expression for HO-1 was minimal in both normal salivary glan

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10

International, Journal of Medical Science and Innovative Research (IJMSIR). "Unravelling ectopic tumour pleomorphic adenoma of cheek - A Case Report." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 1 (2024): 131–35. https://doi.org/10.5281/zenodo.15369520.

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<strong>Abstract</strong> Pleomorphic adenoma is a benign tumor most commonly occurring in parotid gland. The tumour was originally believed to be “mixed” neoplastic cells derived from both duct epithelial cells and myoepithelial cells. However, it is now known to be a neoplasm of purely ectodermal cells. It affects most of the major as well as minor salivary glands. Palate is the most commonly affected minor salivary gland amongst other site followed by lips, cheeks, gingiva, floor of the mouth, and tongue. Pleomorphic Adenoma of buccal minor salivary glands is a very rare occurre

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11

Mitri, Stephanie, Joseph Yammine, and Khalil Diab. "Successful Resection of an Endobronchial Pleomorphic Adenoma Using Cryotherapy: A Case Report." International Journal of Clinical Research 2, no. 1 (2021): 17–20. http://dx.doi.org/10.38179/ijcr.v2i1.58.

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Background: Pleomorphic adenomas are very rare benign bronchial tumors. They are typically either removed surgically, or if not amenable to surgery, via therapeutic bronchoscopy. We present the first case of an endobronchial pleomorphic adenoma removed by cryotherapy. Case Report: This is the case of a 54-year-old man with a right middle lobe pleomorphic adenoma that was detected incidentally during a bronchoscopy, which was performed due to acute respiratory failure and presence of ground glass opacities on imaging. The tumor led to a chronic cough and partial right middle lobe atelectasis. I

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12

Pomianek, Malwina, Seweryn Ziajor, Artur Bednarski, et al. "Pleomorphic adenoma of the nasal cavity in a 21 – year – old patient – case report." Journal of Education, Health and Sport 69 (May 16, 2024): 49396. http://dx.doi.org/10.12775/jehs.2024.69.49396.

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Introduction and aim: Adenoma pleomorphum (multiform adenoma) is the most popular bening tumor, that originates from the salivary glands. Neoplasm develops mainly from large salivary glands and its occurrence in the nasal cavity is rare and falls mainly in the 3-6 decade of life. Only 1% of all pleomorphic adenomas develop in the nasal and sinus cavities. Despite being a benign tumor, malignant transformation can occur in 2-10% of cases. Description of the case: We report a case of a 21-year-old female ethnically Polish patient with nasal multiform adenoma with initial diagnosis, which indicat

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Gabelloni, Michela, Lorenzo Faggioni, Simona Attanasio, et al. "Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study." Diagnostics 10, no. 11 (2020): 900. http://dx.doi.org/10.3390/diagnostics10110900.

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Our purpose is to evaluate the performance of magnetic resonance (MR) radiomics analysis for differentiating between malignant and benign parotid neoplasms and, among the latter, between pleomorphic adenomas and Warthin tumors. We retrospectively evaluated 75 T2-weighted images of parotid gland lesions, of which 61 were benign tumors (32 pleomorphic adenomas, 23 Warthin tumors and 6 oncocytomas) and 14 were malignant tumors. A receiver operating characteristics (ROC) curve analysis was performed to find the threshold values for the most discriminative features and determine their sensitivity,

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14

Forde, C. T., R. Millard, and S. Ali. "Soft Palate Pleomorphic Adenoma of a Minor Salivary Gland: An Unusual Presentation." Case Reports in Otolaryngology 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/3986098.

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Approximately 10% of pleomorphic adenomas occur in the minor salivary glands with the palate being the most common site. Pleomorphic adenomas account for the majority of palatal tumours; however, minor salivary gland tumours have a higher risk of malignancy compared to tumours of the major salivary glands, so appropriate diagnostic evaluation should be prompt. We present a case of a 52-year-old man with a longstanding history of a soft palate pleomorphic adenoma which required excision under general anaesthetic via a mandibular swing approach. As well as the surgical approach to access this tu

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15

Sim, David W., Arnold G. D. Maran, and Douglas Harris. "Metastatic salivary pleomorphic adenoma." Journal of Laryngology & Otology 104, no. 1 (1990): 45–47. http://dx.doi.org/10.1017/s0022215100111776.

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AbstractPleomorphic adenomas of the salivary gland are usually regarded as benign tumours. We report a case in which a solitary pulmonary metastasis arose from a pleomorphic adenoma of the right parotid gland. The mechanism of metastasis is discussed.

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Gillenwater, Ann, Kenneth Hurr, Pat Wolf, John G. Batsakis, Helmuth Goepfert, and Adel K. El-Naggar. "Microsatellite Alterations at Chromosome 8q Loci in Pleomorphic Adenoma." Otolaryngology–Head and Neck Surgery 117, no. 5 (1997): 448–52. http://dx.doi.org/10.1016/s0194-59989770012-3.

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OBJECTIVE: To determine the extent, localization, and clinical significance of microsatellite loci alterations at sites of reported cytogenetic abnormalities in pleomorphic adenomas. BACKGROUND: Pleomorphic adenoma is a benign salivary gland tumor with a propensity for recurrence and potential for malignant conversion. Although its cause remains unclear, clonal cytogenetic abnormalities have been reported consistently. DESIGN: DNA extracted from paired normal and tumor tissue specimens from 1 patient with carcinoma ex pleomorphic adenoma and 17 patients with pleomorphic adenoma (3 contained fo

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17

Malanchuk, V. O., I. S. Brodetskyi, and M. S. Krotevych. "Application of immunohistochemical markers in diagnostics of various histological types of pleomorphic adenomas of the salivary glands." Clinical Dentistry, no. 1 (July 1, 2020): 34–42. http://dx.doi.org/10.11603/2311-9624.2020.1.11219.

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The morphological verification of tumors as a diagnostic method has been the basis for establishing the final diagnosis for a long time. According to various data, the accuracy of the diagnosis ranges from 80–85 %, depending on the type of tumor (benign or malignant) and its differentiation. With the introduction of immunohistochemical studies for the final diagnosis of tumors, the percentage of verified tumors has increased significantly. The aim of the study – determination of peculiarities of pathogenesis of various histological types of pleomorphic adenomas of the salivary glands app

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18

Sroka, Paweł, and Sławomir Okła. "Giant pleomorphic adenoma of nasal cavities and paranasal sinuses." Polski Przegląd Otorynolaryngologiczny 7, no. 1 (2018): 1–5. http://dx.doi.org/10.5604/01.3001.0012.1467.

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Pleomorphic adenoma is benign tumor of the salivary glands. It is the most common neoplazm both major and minor salivary glands. Only in 1% of cases pleomorphic adenoma occur in the sinonasal cavities. The histopalogical wiew of pleomorphic adenomas originating from small salivary glands is different in higher cellularity and lower stromal component than those from major salivary glands. It is a benign tumor but it should be treated as a clinically uncertain. Malignant transformation of pleomorphic adenoma can occur in 2-10% of cases, The aim of this study was to present he case of 37-year-old

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Agarwal, Lakshmi, Vishakha Sharma, and Lokesh Rawat. "A rare case report of metastasizing pleomorphic adenoma ?of parotid gland." IP Archives of Cytology and Histopathology Research 8, no. 4 (2024): 261–63. http://dx.doi.org/10.18231/j.achr.2023.059.

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Pleomorphic adenoma is one of the most common benign parotid gland tumors. Local recurrence can occur in 1% to 5% of cases after surgery. Metastasizing pleomorphic adenomas are very rare entity and have rarely been reported. Histologically it has benign morphology. Metastasis can occur in bone, lymph nodes, the lung, oral cavity, pharynx, skin, liver, kidney, and central nervous system. We hereby report a case of pleomorphic adenoma of the parotid gland metastasizing to lungs.

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Tejendrasingh, Thakur Rahul, and Sonawale Sanjay Kumar Laxmanrao. "Pleomorphic Adenoma of the Nasal Septum." An International Journal of Otorhinolaryngology Clinics 5, no. 3 (2013): 151–53. http://dx.doi.org/10.5005/jp-journals-10003-1132.

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ABSTRACT Pleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum. How to cite this article Tejendrasingh TR, Laxmanrao SSK. Pleomorphic Adenoma of the Nasal Septum. Int J Otorh

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Tejendrasingh, Thakur Rahul, and Sonawale Sanjay Kumar Laxmanrao. "Pleomorphic Adenoma of the Nasal Septum." An International Journal of Otorhinolaryngology Clinics 6, no. 1 (2014): 10–12. http://dx.doi.org/10.5005/aijoc-6-1-10.

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ABSTRACT Pleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum.

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Dantas Cassali, Geovanni, Angélica Cavalheiro Bertagnolli, Enio Ferreira, Karine Araújo Damasceno, Conrado de Oliveira Gamba, and Cecília Bonolo de Campos. "Canine Mammary Mixed Tumours: A Review." Veterinary Medicine International 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/274608.

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Mammary mixed tumours are the most frequent neoplasias in female dogs. In humans, mixed tumours are frequently found in the salivary glands and are known as pleomorphic adenomas. In addition to their histomorphologic similarities, mixed tumours and pleomorphic adenomas have the potential to become malignant and give rise to carcinomas in mixed tumours and carcinomas ex-pleomorphic adenoma, respectively. The factors associated with malignant transformation are still poorly known in the case of canine mixed tumours. However, this form of neoplasia tends to be associated with a better prognosis t

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Kumar, R., D. Nair, P. Pai, and P. Chaturvedi. "Laser Resection of Subglottic Pleomorphic Adenoma." International Journal of Head and Neck Surgery 1, no. 3 (2010): 175–77. http://dx.doi.org/10.5005/jp-journals-10001-1034.

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Abstract Tumors arising from the minor salivary glands in the larynx are rare. The most common tumors occurring here are adenoid cystic carcinomas.1 Among the benign tumors, pleomorphic adenoma is the most common.1 We present a case of subglottic pleomorphic adenoma which was managed by endolaryngeal endoscopic CO2 laser surgery. Laser as a primary treatment modality for the treatment of subglottic pleomorphic adenomas has not been well-described, as only one case has been reported in literature using this modality.

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Cebeci, Hakan, Mehmet Öztürk, Mehmet Sedat Durmaz, Abidin Kılınçer, Ömer Erdur, and Bahar Çolpan. "Evaluation of benign parotid gland tumors with superb microvascular imaging and shear wave elastography." Journal of Ultrasonography 20, no. 82 (2020): 185–90. http://dx.doi.org/10.15557/jou.2020.0031.

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Aim of the study: This study aimed to examine the role of superb microvascular imaging and shear wave elastography for the pre-surgical evaluation of common parotid tumors. Material and methods: This single-center prospective study included 37 patients with parotid gland lesions. After institutional review board approval, grayscale, shear wave elastography and superb microvascular imaging ultrasound examinations were performed prior to biopsy or operation. The diagnosis of the lesions was based on cytological/pathological evaluation after the ultrasound examinations. Pleomorphic adenomas and W

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Brodetskyi, I. S., V. A. Malanchuk, and V. E. Dosenko. "USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (2020): 149–54. http://dx.doi.org/10.31718/2077-1096.20.1.149.

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Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland,

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Pingarrón-Martín, Lorena, L. J. Arias-Gallo, G. Demaría-Martínez, and M. Chamorro Pons. "Remarkable Triple Pleomorphic Adenoma Affecting both Parotid and Submandibular Glands." Craniomaxillofacial Trauma & Reconstruction 8, no. 2 (2015): 129–31. http://dx.doi.org/10.1055/s-0034-1378184.

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The objective of this article is to present the first case reported in the literature of metachronous pleomorphic adenoma of bilateral parotid glands and submaxillary gland. The authors report the case of a 27-year-old female with metachronous mixed tumors in her right parotid and submandibular glands. The patient has no history of previous radiotherapy. All three lesions were diagnosed by fine-needle aspiration. The histopathologic evaluation of all three major salivary gland masses demonstrated pleomorphic adenomas, with no occult malignancy observed on serial sections. The presentation of p

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Brodetskyi, Igor S., Olena O. Dyadyk, Mykhailo S. Myroshnychenko, and Valentina I. Zaritska. "MORPHOLOGICAL CHARACTERISTICS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS (ANALYSIS OF THE SURGICAL MATERIAL)." Wiadomości Lekarskie 73, no. 11 (2020): 2339–44. http://dx.doi.org/10.36740/wlek202011103.

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The aim of the study is to reveal the morphological features of pleomorphic adenomas of the salivary glands during a comprehensive examination of the surgical material. Materials and methods: Surgical material from 30 patients with pleomorphic adenomas of the salivary glands was studied. Microspecimens stained with hematoxylin and eosin were studied, using an Olympus BX-41 microscope (Japan) with subsequent processing with the Olympus DP-soft version 3.1 software, which was used to conduct a morphometric study. By morphometry in the tumor tissue, the specific volumes of the parenchyma and stro

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Brodetskyi, Igor S., Olena O. Dyadyk, Vladislav A. Malanchuk, Mykhailo S. Myroshnychenko, and Mykhailo S. Krotevych. "IMMUNOHISTOCHEMICAL FEATURES OF THE EXPRESSION OF HUMAN PAPILLOMA VIRUS TYPE 16 IN PLEOMORPHIC ADENOMAS OF SALIVARY GLAND." Wiadomości Lekarskie 74, no. 1 (2021): 7–10. http://dx.doi.org/10.36740/wlek202101101.

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The aim is to reveal the immunohistochemical features of human papilloma virus type 16 expression in various histological variants of pleomorphic adenomas of the salivary gland. Materials and methods: The material of the study was surgical and biopsy material from 30 patients with pleomorphic adenomas of the salivary glands, among which in 15 cases mesenchymal was detected, in 10 – mixed, in 5 cases – epithelial histological variant, respectively. Immunohistochemical study was performed, using mouse monoclonal antibody to human papilloma virus type 16. Visualization was performed, using an EnV

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Kushwaha, Naveen kumar, Pradeep Jaiswal, Harish Shiva Murthy, and Pawan Kumar Dhaman. "Phenotypic plasticity in parotid tumours: insights from a surgical oncologist’s perspective." BMJ Case Reports 17, no. 12 (2024): e259115. https://doi.org/10.1136/bcr-2023-259115.

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Phenotypic plasticity refers to the ability of tumour cells to undergo molecular and phenotypic changes in response to microenvironmental stresses, genetic and epigenetic alterations, or treatment-induced selective pressures, thereby promoting tumour progression. This case report discusses a man in his 70s with pleomorphic adenoma of the parotid, where phenotypic plasticity led to the development of pleomorphic liposarcoma in the parotid through transdifferentiation. Sarcomas can arise in the parotid from pre-existing pleomorphic adenomas or de novo, with only eight reported cases of primary p

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Chow, Louis T. C., and W. H. Chow. "Co-existing pleomorphic and tubular basal cell adenomas of the parotid gland." Journal of Laryngology & Otology 111, no. 2 (1997): 182–85. http://dx.doi.org/10.1017/s0022215100136801.

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AbstractWe report a hitherto undescribed case of co-existence of a pleomorphic adenoma and a tubular basal cell adenoma affecting the superficial lobe of the left parotid gland of a 53-year-old man. The histology of the pleomorphic adenoma is also of interest in that the prominent adipose metaplasia of its myxoid stroma yielded an appearance reminiscent of myxoid lipoma. The tubular basal cell adenoma showed gross cystic change, and its solid portion consisted of closely packed tubules lined by double layers of cuboidal cells with little intervening stroma. Unlike Warthin's tumour and membrano

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Rasul, Faiz. "Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands." Journal of Islamabad Medical & Dental College 11, no. 3 (2022): 152–57. http://dx.doi.org/10.35787/jimdc.v11i3.777.

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. Background: Pleomorphic adenomas (PAs) are the most common type of salivary gland tumors (SGTs) which may undergo malignant transformation to Carcinoma ex PA (CaExPA). The purpose of this study was to determine mitotic index (MI) and expression of Ki-67 in Pleomorphic adenomas of salivary gland tumors. Methodology: This study was carried out on sixty patients of pleomorphic adenoma. Slides with specimens were stained with Hematoxylin & Eosin to count Mitotic index. Labeling Index (LI) of Ki-67 was determined immunohistochemically. Mitotic figures (MF) were counted in 10 HPF s

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Prado, Renata Falchete do, Camila Lopes Cardoso, Alberto Consolaro, and Antonio Luis Assis Taveira. "Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin." Brazilian Dental Science 17, no. 1 (2014): 23. http://dx.doi.org/10.14295/bds.2014.v17i1.944.

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<p>The objective of this study was to investigate the distribution of b-catenin in pleomorphic adenomas and the basal cell adenomas to<strong> </strong>clarify its possible role in the etiopathogenesis of these two lesions. The expression of b-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin-embedded specimens by the avidin-biotin-peroxidase complex method in 10 pleomorphic adenomas and 2 basal cell adenomas. The specimens were analyzed taking into account intensity, distribution and association with myoepithelial cells.

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Buiret, G. "Pleomorphic adenoma of the nasal cavity." Journal of Clinical Otorhinolaryngology 3, no. 1 (2021): 01–04. http://dx.doi.org/10.31579/2692-9562/026.

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Pleomorphic adenomas represent 80% of the salivary gland’s benign tumors. They are most often found in the parotid gland or in the submandibular gland. Pleomorphic adenomas of the nasal cavity are rare, with less than fifty cases reported to date. There are no treatment or follow up guidelines. The purpose of this article is to review the cases already described in the literature and to share our clinical experience. We describe the case of a 38-year-old woman with a history of a slow growing intranasal tumor with recurrent epistaxis, obstruction, and aesthetic deformation. The pre-operative a

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Siti, Nursiah, Y.M. Rambe Andrina, and W.R. Nasution Irnanda. "Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary gland tumors." International Journal of Innovative Science and Research Technology 7, no. 6 (2022): 26–29. https://doi.org/10.5281/zenodo.6642417.

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Pleomorphic adenoma is one kind of tumor which is the most common benign tumor of major salivary gland tumors. And can occur in the minor salivary gland tissue that can be found in the nasal cavity. Intranasal pleomorphic adenomas are usually formed by the mucous glands of the nasal septum. We found the pathology result of endoscopic surgery. The purpose of this study was to demonstrate an endoscopic approach to surgery for pleomorphic adenoma of the nasal septum. A 34-year-old woman presented with complaints of nasal congestion and occasional bleeding for at least 3 years. We provide treatmen

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Akın, İstemihan, Tuğba Karagöz, Murad Mutlu, Mehmet Şahan, and Evrim Önder. "Pleomorphic Adenomas of the Parapharyngeal Space." Case Reports in Otolaryngology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/168401.

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Background.Parapharyngeal space is one of potential facial planes for neoplasms and infections and represents less than 1% of all head and neck tumours. Occurrence of the pleomorphic adenoma in the parapharyngeal space is a rarity.Case Presentation.Here, three giant pleomorphic adenomas of different sizes occupying the parapharyngeal space in three patients are reported. Extensive preoperative diagnostic workup was done in order to verify the nature and size of the tumour and the proximity to the large vessels. Review of the literature, clinical features, pathology, radiological findings, and

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Badia, Lydia, Justin N. Weir, and Anthony C. Robinson. "Heterotopic pleomorphic adenoma of the external nose." Journal of Laryngology & Otology 110, no. 4 (1996): 376–78. http://dx.doi.org/10.1017/s0022215100133675.

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AbstractPleomorphic adenomas arising from sites other than the major or minor salivary glands are uncommon. We describe a case of pleomorphic adenoma in the subcutaneous tissue of the nasomaxillary crease. An identical tumour was previously excised from the right nasal cavity. The possible aetiology of these heterotopic salivary gland tumours is discussed.

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Kapoor, V. K., and T. K. Chattopadhyay. "Treatment of pleomorphic adenomas." British Journal of Surgery 73, no. 10 (1986): 862. http://dx.doi.org/10.1002/bjs.1800731033.

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Mahamad Apandi, Nurul, Siew Chan, and Yen Toh. "Differential Expression of Mucin in Salivary Gland Tumours." Medicina 60, no. 6 (2024): 920. http://dx.doi.org/10.3390/medicina60060920.

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Background and Objectives: Mucin has been implicated via various mechanisms in the development and growth of tumour cells. However, mucin expression studies in salivary gland tumours are limited, especially with samples from minor salivary glands. This study aims to investigate and compare mucin expression in benign and malignant salivary gland tumours of minor and major salivary gland origins. Materials and Methods: Special stains were used to stain neutral mucin (Periodic acid Schiff), sialomucin (Alcian Blue) and sulfomucin (Aldehyde Fuschin) within tissues from six normal salivary glands a

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Bhardwaj, Aparna, and Sonam Rathi. "Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity." An International Journal Clinical Rhinology 9, no. 3 (2016): 146–48. http://dx.doi.org/10.5005/jp-journals-10013-1290.

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ABSTRACT Pleomorphic adenomas occurring in the nasal cavity are rarely encountered; nevertheless, there is abundance of minor seromucinous glands in that region. Most cases present with a painless, slowly progressing unilateral nasal obstruction, a nasal mass, and epistaxis. Herewith, we present an unusual case of pleomorphic adenoma arising from the lateral wall of the right nasal cavity in a 41-year-old male who complained of right nasal obstruction with no history of epistaxis. Rigid nasal endoscopy revealed a swelling continuous with right inferior concha. Computed tomography showed a well

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Bhardwaj, Aparna, and Sonam Rathi. "Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity." An International Journal Clinical Rhinology 10, no. 1 (2017): 11–13. http://dx.doi.org/10.5005/jp-journals-10013-1295.

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ABSTRACT Pleomorphic adenomas occurring in the nasal cavity are rarely encountered; nevertheless, the abundance of minor seromucinous glands in that region is seen. Most cases present with a painless, slowly progressing unilateral nasal obstruction, a nasal mass, and epistaxis. Herewith, we present an unusual case of pleomorphic adenoma arising from the lateral wall of right nasal cavity in a 41-year-old male, who complained of right nasal obstruction with no history of epistaxis. Rigid nasal endoscopy revealed a swelling continuous with right inferior concha. Computed tomography showed a well

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FAIZAL, Felice, Ankur AHUJA, and R. CHATTERJEE. "Pleomorphic Adenoma of Three Different Sites: a Consecutive Case Series." Medicina Moderna - Modern Medicine 28, no. 2 (2021): 253–56. http://dx.doi.org/10.31689/rmm.2021.28.2.253.

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Background: Pleomorphic adenomas are benign salivary gland tumors predominantly arising from the superficial lobe of the parotid gland and rarely from the small salivary glands located at various locations including parotid, lacrimal duct, lip, floor of the mouth etc. Surgical excision of the tumor mass is the treatment of choice with utmost care taken to preserve the facial nerve in cases involving the parotid gland. Case details: This case series highlights three consecutive cases of pleomorphic adenoma arising from three different locations. Conclusion: Pleomorphic adenoma is the commonest

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E, Deepika, and Dhivya K. "Pleomorphic Adenoma of The Palate – A Case Report And Review." International Journal of Contemporary Dental Research 2, no. 1 (2024): 6–13. http://dx.doi.org/10.62175/apdch2402.

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Pleomorphic Adenoma also known as mixed tumour, is one of the most common Neoplasms of the Salivary Gland. It consists of cells that can differentiate into epithelial and mesencephalic cells. The major Salivary gland that is affected by this tumor is the Parotid Gland. Among the minor salivary glands, Palate is the most frequently affected site. About 60% of all Pleomorphic Adenomas of Palates originate from this site. The majority of patients with this tumor are in the 30‟–50‟ age range. The most common manifestation of this tumor is slowly progressing asymptomatic Swelling. The diagnosis of

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Mouhamad Ezadine, Wah Sidi El Moctar, Razika Bencheikh, Mohammed Anas Benbouzid, and Leila Essakalli. "Pleomorphic adenoma of the nasal septum: A rare entity and review of literature." World Journal of Advanced Research and Reviews 25, no. 30 (2025): 291–95. https://doi.org/10.30574/wjarr.2025.25.3.0673.

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Introduction: Pleomorphic adenoma is a common benign salivary gland tumor, rarely occurring in the nasal cavity. These tumors, predominantly arising from the nasal septum, present diagnostic challenges due to their rarity and resemblance to other nasal masses. Case Report: A 58-year-old male presented with an 8-month history of left-sided nasal obstruction and occasional epistaxis. Nasal endoscopy and imaging revealed a confined nasal septal mass, confirmed as pleomorphic adenoma on histopathology. The tumor was successfully excised via endoscopic surgery. After two years of follow-up, no recu

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Arora, Archana, and Karan Sharma. "Pleomorphic adenoma of the nasal cavity- an unusual presentation." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 1 (2016): 162. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20164824.

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<p class="abstract">Pleomorphic adenomas (mixed tumors) are the most common benign tumor of the major salivary glands. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual. We report a rare case of large sized pleomorphic adenoma arising from the nasal septum. A 42-year-old man presented with a 3 month history of multiple episodes of nasal bleeding and obstruction on right side of nose. On examination we found a non-tender firm mass extending upto the nasal vestibule which bled on probing. Computed tomograp

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Rodrigues, Flávia, Débora Colares, Renata Ribeiro, Pedro Santos, and Lélia Souza. "A 14-year retrospective study on clinical and histopathological features of epithelial salivary gland neoplasms." Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 66, no. 1 (2025): 17–24. https://doi.org/10.24873/j.rpemd.2025.03.1421.

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Objectives: To investigate and describe the clinicopathological profile of pleomorphic adenoma, salivary adenoid cystic carcinoma, and mucoepidermoid carcinoma cases at a Northeast Brazilian Oral Pathology referral center. Methods: Clinical features, histopathological diagnoses, subtypes, and specific histopathological features were collected from all cases previously diagnosed as pleomorphic adenoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma between 2008 and 2021. Results: Among 9613 cases diagnosed at the service, 86 (0.75%) were salivary gland neoplasms, included in this study.

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Myroshnychenko, Mykhailo S., Igor S. Brodetskyi, Vladislav A. Malanchuk, et al. "AN INTEGRATED APPROACH TO THE MORPHOLOGICAL DIAGNOSIS OF DIFFERENT TYPES OF PLEOMORPHIC ADENOMAS OF THE SALIVARY GLAND: LONG-TERM RESEARCH RESULTS." Wiadomości Lekarskie 75, no. 7 (2022): 1673–77. http://dx.doi.org/10.36740/wlek202207111.

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The aim: To describe an integrated approach to the morphological diagnosis of different types of pleomorphic adenomas of the salivary gland. Materials and methods: Surgical and biopsy material from 30 patients with pleomorphic adenomas of epithelial, mixed and mesenchymal variants was studied using histological, immunohistochemical, genetic, morphometric and statistical methods. Results: The results of research allowed us to identify methods for determination the pleomorphic adenomas types. The first method requires an immunohistochemical reaction with a monoclonal antibody to human papillomav

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Hughes, Laura, Penelope A. McKelvie, and Alan A. McNab. "Presumed Lacrimal Gland Pleomorphic Adenoma With Extensive Ossification and Necrosis." Ophthalmic Plastic & Reconstructive Surgery 40, no. 3 (2024): e91-e94. http://dx.doi.org/10.1097/iop.0000000000002620.

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Calcification within pleomorphic adenomas of the lacrimal gland is well recognized but uncommon, being seen more readily in lacrimal gland carcinomas. Bony formation, ossification, in pleomorphic adenomas of the lacrimal glands is even rarer. Together with extensive sclerosis, or “coagulative necrosis,” ossification and necrosis should alert the clinician to the risk of malignant transformation. However, both can mimic carcinomatous change, leading to misinterpretation of malignancy in an otherwise benign lacrimal gland neoplasm. We present 2 case reports of patients with clinically presumed p

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Zarbo, Richard J., Anil R. Prasad, Joseph A. Regezi, Allen M. Gown, and Adnan T. Savera. "Salivary Gland Basal Cell and Canalicular Adenomas." Archives of Pathology & Laboratory Medicine 124, no. 3 (2000): 401–5. http://dx.doi.org/10.5858/2000-124-0401-sgbcac.

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Abstract Objective.—To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation. Design.—Immunohistochemical evaluation of 25 salivary gland basal cell and canalicular adenomas. Setting.—Archival pathology material from the files of Henry Ford Hospital, Detroit, Mich, and the University of California at San Francisco. Results.—All basal cell adenoma variants exhibit some degree of myoepithelial cell participation with periductal, epithelioid, and spindled (stromal-

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Brodetskyi, Igor S., Vladislav A. Malanchuk, Mykhailo S. Myroshnychenko, et al. "INFLUENCE OF THE PATIENT’S SEX AND AGE, VOLUMES OF THE SALIVARY GLAND AND PLEOMORPHIC ADENOMA ON THE TUMOR HISTOLOGICAL VARIANTS." Polski Merkuriusz Lekarski 51, no. 5 (2023): 475–81. http://dx.doi.org/10.36740/merkur202305105.

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Aim: The purpose of the study was to identify the influence of the patient’s sex and age, the volumes of the salivary gland and pleomorphic adenoma on the histological variants of the tumor. Materials and Methods: The study included 21 women and 9 men with pleomorphic adenomas of the salivary gland. In 15 cases, a mesenchymal variant of pleomorphic adenoma was identified, in 5 cases – an epithelial variant, in 10 cases – a mixed variant. The average age of the patients was 39.7±2.9 years. Patients with pleomorphic adenomas underwent magnetic resonance imaging using a Siemens MAGNETOM Aera 1.5T

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Chavan, Shrinivas S., KS Bhople, Jeevan N. Vedi, Prateek V. Jain, and Mangala Sonavani. "Giant Intranasal Pleomorphic Adenoma: A Rare Case Report." An International Journal Clinical Rhinology 6, no. 2 (2013): 96–99. http://dx.doi.org/10.5005/jp-journals-10013-1162.

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ABSTRACT Pleomorphic adenoma, a heterogeneous mixture of epithelial and myoepithelial cells, commonly found in major salivary glands, accounts for about 3% of benign head and neck tumors. Intranasal pleomorphic adenoma (INPA) is an extremely rare variant forming a mere 8% of all pleomorphic adenomas. Majority of these arise from the nasal septum (82-90%) with only about 8% showing attachment to the lateral nasal wall. Various theories explaining etiopathological basis of INPA have been proposed but none explains its predominance in females in 3rd to 6th decade of life. Hallmark of histopatholo

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