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Journal articles on the topic 'Pleural fluid Cytology'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

López-Córdova, Frida, Hugo Vega-Huerta, Gisella Luisa Elena Maquen-Niño, Jaime Cáceres-Pizarro, Ivan Adrianzén-Olano, and Oscar Benito-Pacheco. "Construction of a New Data Set of Pleural Fluid Cytological Images for Research." International Journal of Online and Biomedical Engineering (iJOE) 21, no. 07 (2025): 138–51. https://doi.org/10.3991/ijoe.v21i07.54323.

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The limited availability of standardized datasets has hindered the implementation of artificial intelligence (AI) models in serous fluid cytology, particularly in pleural fluid analysis. In this paper, we present the construction of a dataset of pleural fluid cytology images. The objective is to generate a dataset of pleural fluid cytologic images validated by two pathologists and classified into five categories for cell diagnosis, which will be used to train AI models. As a methodology, the images represent pleural fluid cytology samples that have been prepared through medical procedures and

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2

Ferguson, John, Michal Kazimir, Michael Gailey, Frank Moore, and Earl Schott. "Predictive Value of Pleural Cytology in the Diagnosis of Complicated Parapneumonic Effusions and Empyema Thoracis." Pulmonary Medicine 2020 (May 21, 2020): 1–5. http://dx.doi.org/10.1155/2020/7175451.

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Introduction. Complicated parapneumonic effusions (CPE) are distinguished from uncomplicated parapneumonic effusions (UPE) by the ability to resolve without drainage. Determinants include pleural pH, pleural glucose, and pleural LDH, along with microbiologic cultures. Inflammation mediated by neutrophil chemotactic cytokines leads to fibrinous loculation of an effusion, and the degree of this inflammation may lead to a CPE. One role of the pathologist is to evaluate for the presence of malignancy in a pleural effusion; however, the ability of the pathologist to distinguish a CPE from UPE has n

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Arnawan, Herdi, Nikmatia Latief, and Muhammad Ilyas. "Kesesuaian computed tomography scan-base scoring system dengan hasil sitologi cairan pleura dalam membedakan efusi pleura maligna dan benigna." Jurnal Biomedik:JBM 14, no. 1 (2022): 23. http://dx.doi.org/10.35790/jbm.v14i1.34137.

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Abstract: The research aims at assessing the congruity CT scan-base scoring system according to Porcel and the pleural fluid cytology result in distinguishing the malignant from benign pleural effusions. The research used the diagnostic test by assessing the congruity CT scan-base scoring system according to Porcel with pleural fluid cytology result in distinguishing the malignant from benign pleural effusions through the Chi-square test and assessing the sensitivity and specificity of the pleural effusion score. The research result indicates that there are 71 samples with the pleural effusion

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Auliya, Husnul, Roza Kurniati, and Fauzar. "Diagnosis and Management of Malignant Pleural Effusion: A Narrative Literature Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 12 (2022): 2449–56. http://dx.doi.org/10.37275/bsm.v6i12.624.

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Malignant pleural effusion (MPE) is defined as an effusion that occurs in association with malignancy, as evidenced by the finding of malignant cells on pleural fluid cytology or pleural biopsy. The pathophysiology of MPE is not yet clear, but several hypotheses have been developed to explain the mechanism of MPE. Accumulation of effusion in the pleural cavity occurs due to increased vascular permeability due to the inflammatory reaction caused by the infiltration of cancer cells in the parietal and/or visceral pleura. Other possible mechanisms are the direct invasion of the tumor adjacent to

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Liz Maria Joseph, Sheeja Sainulabdeen, Deepa Sujatha, and Sankar Sundaram. "Diagnostic utility of cytospin in comparison to cell block in peritoneal and pleural fluid cytology." Asian Journal of Medical Sciences 13, no. 11 (2022): 254–59. http://dx.doi.org/10.3126/ajms.v13i11.44526.

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Background: Fluid cytology plays an important role in delineating benign from malignant effusions, tumor staging, and also in diagnosing recurrences. Various methods are used in cytology for the preparation of smears. As the accurate diagnosis of the fluids aids in clinical decisions, the method of preparation of cytology smears, it is very important. Cytospin preparation of smears is one of the methods which provide higher cellular yield with better preservation of cellular morphology and is less time consuming. On the other hand, cell block method gives superior architectural details and pro

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Pal, Subrata, Kingshuk Bose, Abhishek Sharma, and Mrinal Sikder. "Microfilaria in pleural fluid cytology: A rare finding." Journal of Laboratory Physicians 9, no. 02 (2017): 143–44. http://dx.doi.org/10.4103/0974-2727.199638.

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AbstractLymphatic filariasis is endemic in India and Southeast Asia. Detection of microfilaria is infrequently reported during cytological evaluation of various lesions or body cavity fluids. Presence of microfilaria in pleural fluid cytology is very rare finding even in endemic areas. Few cases of accidental finding of microfilaria have been reported in association with malignant pleural effusion. But pleural effusion of filarial origin is extremely rare manifestation. Here we report a classical case of microfilaria in pleural fluid cytology.

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Allama, Amr M., Dalia H. Abou-Elela, and Islam M. Ibrahim. "Pleural and serum markers for diagnosis of malignant pleural effusion." Asian Cardiovascular and Thoracic Annals 28, no. 9 (2020): 560–65. http://dx.doi.org/10.1177/0218492320948311.

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Background Differentiation between benign and malignant exudative pleural effusion remains a clinical challenge. Recently, several markers have been reported to increase the diagnostic accuracy of malignant pleural effusion, with controversial results. Methods Patients with exudative pleural effusion were divided into 2 groups: a malignant pleural effusion group (39 patients) diagnosed by malignant cells in pleural fluid cytology or by malignant infiltration of the pleura on pleural biopsy, and a benign pleural effusion group (51 patients) with neither malignant cells in pleural fluid cytology

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Bhattacharya, Somnath, Tapan D. Bairagya, Anirban Das, Abhijit Mandal, and Sibes K. Das. "Closed Pleural Biopsy is Still Useful in the Evaluation of Malignant Pleural Effusion." Journal of Laboratory Physicians 4, no. 01 (2012): 035–38. http://dx.doi.org/10.4103/0974-2727.98669.

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ABSTRACT Background: Pleural fluid cytology for malignant cells is the easiest way to diagnose malignant pleural effusion with good sensitivity and specificity. With the introduction of medical thoracoscopy, the use of closed pleural biopsy for the diagnosis of cytology negative malignant pleural effusion is gradually decreasing. However use of thoracoscopy is limited due to its high cost and procedure related complications. Aims: The aim was to assess the usefulness of closed pleural biopsy in the diagnosis of malignant pleural effusion. Materials and Methods: Sixty-six patients of pleural ef

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Prabhudesai, Rutuja, Ashish Deshmukh, Sunil Jadhav, Hafiz Deshmukh, and Shivprasad Kasat. "Pleural Fluid Cytology as a Means of Diagnosing Malignant Pleural Effusions." International Journal of Science and Research (IJSR) 14, no. 1 (2025): 330–31. https://doi.org/10.21275/sr25107123723.

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10

Dermawan, Josephine Kam Tai, and Maria Luisa Policarpio-Nicolas. "Malignancies in Pleural, Peritoneal, and Pericardial Effusions." Archives of Pathology & Laboratory Medicine 144, no. 9 (2020): 1086–91. http://dx.doi.org/10.5858/arpa.2019-0429-oa.

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Context.— The incidence and types of malignancies in effusion cytology are largely limited to studies performed in the 1970s through the 1990s. Objective.— To examine how the incidence of different types of malignancies in effusions has changed with time. Design.— A computerized search for fluid cytology from 2000 through 2016 (database included age, gender, cytologic diagnosis, and type of malignancy) was performed, and all cases were reviewed. Results.— Of 30 085 effusion specimens, 3285 (11%) were positive for malignancy (2175 pleural, 955 peritoneal, and 155 pericardial). Of those, 1023 (3

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Kavya, Dr Bollam, Dr Mohd Soheb Sadath Ansari, Dr Sara Ahmed, and Dr K. Ramesh Kumar. "A Study of Serum to Pleural Fluid Albumin Gradient in Differentiation of Exudative and Transudative Pleural Effusion in Comparison to Light’s Criteria." SAS Journal of Medicine 10, no. 05 (2024): 385–89. http://dx.doi.org/10.36347/sasjm.2024.v10i05.019.

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Pleural effusion is the accumulation of fluid between the parietal and visceral pleura called the pleural cavity. It can occur by itself or can be the result of surrounding parenchymal diseases like infection, malignancy or inflammatory conditions. Pleural effusion is one of the major causes of pulmonary mortality and morbidity. Both the visceral and the parietal pleura play an important role in fluid homeostasis in the pleural space. Pleural effusions develop when there is excess hydrostatic pressure in the pulmonary capillaries, when fluid removal is impaired by compromised lymphatic drainag

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12

Hoffmann, Heather, Ellen Schlette, Jeffrey Actor, and L. Jeffrey Medeiros. "Pleural Posttransplantation Lymphoproliferative Disorder Following Liver Transplantation." Archives of Pathology & Laboratory Medicine 125, no. 3 (2001): 419–23. http://dx.doi.org/10.5858/2001-125-0419-ppldfl.

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Abstract A case of posttransplantation lymphoproliferative disorder (PTLD) involving the pleura is reported. The patient was a 57-year-old man who underwent liver transplantation 2 years prior to the development of PTLD. The PTLD was pleural-based and was first detected by radiologic studies as a pleural effusion. Transbronchial biopsy and cytologic examination of 2 pleural fluid specimens were nondiagnostic. Subsequent open-wedge biopsy revealed a monomorphic PTLD, composed of large immunoblasts with plasmacytoid differentiation. Immunohistochemical studies demonstrated B-cell lineage with ex

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Antony, V. B., S. W. Godbey, S. L. Kunkel, et al. "Recruitment of inflammatory cells to the pleural space. Chemotactic cytokines, IL-8, and monocyte chemotactic peptide-1 in human pleural fluids." Journal of Immunology 151, no. 12 (1993): 7216–23. http://dx.doi.org/10.4049/jimmunol.151.12.7216.

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Abstract Pleural effusions secondary to various diseases are associated with the presence of different inflammatory cells. The role of selective chemotactic cytokines in the recruitment of phagocytes to the pleural space is unclear. IL-8 and monocyte chemotactic peptide-1 (MCP-1) are recently described cytokines that are chemotactic for neutrophils and monocytes, respectively. We prospectively studied 63 patients, using strictly defined criteria for their selection. IL-8 concentrations were elevated in both empyema fluid (9.15 +/- 0.89 ng/ml) and parapneumonic effusions (4.7 +/- 0.697 ng/ml) w

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Yang, C. T., M. H. Lee, R. S. Lan, and J. K. Chen. "Telomerase activity in pleural effusions: diagnostic significance." Journal of Clinical Oncology 16, no. 2 (1998): 567–73. http://dx.doi.org/10.1200/jco.1998.16.2.567.

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PURPOSE To determine the diagnostic value of pleural fluid telomerase activity in distinguishing a malignant from a nonmalignant pleurol effusion in a cohort of patients undergoing thoracentesis. PATIENTS AND METHODS Using a polymerase chain reaction (PCR)-based assay, telomerase activity was examined in the pleural fluid cells obtained from 144 consecutive, unselected patients. According to the final diagnosis achieved, these patients were classified into three groups: group I consisted of 70 malignant pleural effusions diagnosed by either fluid cytology or pleural biopsy, group II consisted

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Park, Hong Sik, Yosep Chong, Yujin Lee, et al. "Deep Learning-Based Computational Cytopathologic Diagnosis of Metastatic Breast Carcinoma in Pleural Fluid." Cells 12, no. 14 (2023): 1847. http://dx.doi.org/10.3390/cells12141847.

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A Pleural effusion cytology is vital for treating metastatic breast cancer; however, concerns have arisen regarding the low accuracy and inter-observer variability in cytologic diagnosis. Although artificial intelligence-based image analysis has shown promise in cytopathology research, its application in diagnosing breast cancer in pleural fluid remains unexplored. To overcome these limitations, we evaluate the diagnostic accuracy of an artificial intelligence-based model using a large collection of cytopathological slides, to detect the malignant pleural effusion cytology associated with brea

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Yan, Lei, Prih Rohra, Lin Cheng, and Paolo Gattuso. "Pleural Effusion in Pulmonary and Extrapulmonary Blastomycosis." Acta Cytologica 64, no. 3 (2019): 241–47. http://dx.doi.org/10.1159/000500973.

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Objective: Pleural effusion secondary to blastomycosis infection is an uncommon clinical manifestation of the disease. We undertook a retrospective study to assess the incidence and involvement of pleural effusion in patients with blastomycosis infection. Study Design: Institutional cytology and surgical pathology records were searched from December 1995 to October 2017 for cases of blastomycosis. The cytologic, surgical pathology, and clinical pertinent information was reviewed in detail. Results: A total of 77 cases of blastomycosis infection were recorded, with a male-to-female ratio of 1.7

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Visavadiya, Riya Satishbhai, Dimple Hardikbhai Darad, Mohmadovesh Mohmadyunus Panchbhaiya, and Alaukika Naranbhai Rathwa. "Application of The International System for Reporting Serous Fluid Cytopathology (TIS) on Reporting Various Body Fluids: A Study from a Tertiary Care Hospital of Western India." Annals of Pathology and Laboratory Medicine 11, no. 9 (2024): A245–251. https://doi.org/10.21276/apalm.3378.

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Background: Serous effusion is the accumulation of fluid in body cavities due to various causes, with malignancies being one of the important contributors. The various sites from which fluid can be sent for analysis include the pleural, peritoneal, and pericardial cavities. Materials and Methods: This was a retrospective observational study. A total of 114 fluids were studied. All received body fluid samples sent to the cytopathology section of the pathology department, including pleural and peritoneal fluids, were examined, excluding sputum and broncho-alveolar lavage fluid. Wherever availabl

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Das, Anirban, and Abhishek Pratap. "Primary Malignant Neuroendocrine Tumour of Pleura: First Case Report." Case Reports in Oncological Medicine 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/5462380.

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Metastatic tumours of pleura are the most common malignant tumours causing malignant pleural effusion. Lungs are the most common primary sites. Primary pleural tumours are rarely seen and diffuse malignant mesothelioma is the most common malignant tumour of pleura. Primary malignant neuroendocrine tumour of pleura is not reported in the literature. Here, we report a rare case of primary malignant neuroendocrine tumour of pleura in a fifty-two-year-old, nonsmoker female who presented with right-sided pleural effusion and ipsilateral, dull aching chest pain. Clinical presentations of inflammator

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19

Suneja, Priya, Anju Khairwa, and Nadeem Tanveer. "Convention Smears of Pleural Effusion Cytology Revealing Metastatic Clear Cell Carcinoma of Endometrium: A Rare Case Report and Review of Literature." Journal of Cytology 42, no. 2 (2025): 104–8. https://doi.org/10.4103/joc.joc_98_24.

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Abstract Conventional fluid cytology is a simple and efficient diagnostic modality that plays an imperative role in the workup of serous cavity effusion fluids. Endometrial carcinoma with pleural metastases is quite uncommon, and isolated cases without lung parenchymal involvement are even more uncommon. Herein, we present a case of a 60-year-old female diagnosed with high-grade endometrioid carcinoma with clear cell change, who presented with right-sided pleural effusion, which turned out to be positive for metastatic carcinoma without the involvement of lung parenchyma, making it a rare pres

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Hanifa, Novia, Restu Farizki, James P. Simanjuntak, and Agraini Agraini. "Association of C-Reactive Protein (CRP) Test Results with The Decision on Cytological Examination of Pleural Effusion Fluid." Proceeding International Conference Health Polytechnic of Jambi 2 (November 30, 2023): 133–38. http://dx.doi.org/10.35910/icohpj.v2i0.717.

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Background: Pleural effusion is an abnormal collection of fluid within the pleural lining resulting from a disturbance in the balance affecting the inflow and outflow from the area. Pleural fluid is associated with various medical diseases such as heart failure, pneumonia, and malignancy. Rapid and accurate diagnosis remains a major clinical challenge in patients with suspected pleural infection. As clinical data may be elusive, measurement of biomarkers in pleural fluid can estimate the likelihood of infection, and C-reactive protein (CRP) is the biomarker of choice for detecting inflammatory

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Dhakad, Sapna, Amit Niranjan, Neeraj Pancholi, and Reema Bhushan. "Study of Pleural Fluid Cytology in a Tertiary Care Hospital." International Journal of Science and Research (IJSR) 12, no. 9 (2023): 1358–60. http://dx.doi.org/10.21275/sr23912170211.

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S.P., Vengada Krishnaraj, Gayathri S. Mohan, Vinod Kumar V, and Sridhar R. "Diagnostic Value of Flexible Thoracoscopy in Undiagnosed Cases of Exudative Pleural Effusion." Journal of Evidence Based Medicine and Healthcare 7, no. 47 (2020): 2783–86. http://dx.doi.org/10.18410/jebmh/2020/571.

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BACKGROUND The diagnostic yield of thoracoscopy is 95 %, of pleural fluid cytology it is 62 % and of closed pleural biopsy is 44 %, in malignant effusion. We wanted to study the diagnostic utility of flexible thoracoscopy in undiagnosed exudative pleural effusion and compare the thoracoscopy findings with the histopathology results. METHODS The study was conducted in the Department of Respiratory Medicine, Government Stanley Medical College, Chennai, from January 2019 to January 2020. 40 patients were enrolled in this longitudinal observational study with moderate to massive effusion and were

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Uddin, Kazi Shihab, Md Mahbub Rashid Sarker, Md Abdur Razzaque, and Md Zulfikar Ali. "Pleural fluid cytology, biochemistry and adenosine deminase level study in differentiating tubercular and non tubercular causes of pleural effusion." KYAMC Journal 9, no. 1 (2018): 28–31. http://dx.doi.org/10.3329/kyamcj.v9i1.36620.

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Background: Adenosine deaminase (ADA) level in pleural fluid study has gained popularity for quick diagnosis and treatment of tuberculous pleural effusion in tuberculosis burden countries. Studies have confirmed high sensitivity and specificity across the world. Pleural fluid cytology, biochemistry and malignant cell examinations are already in use and widely available.Objectives: Diagnostic approach to quickly differentiate between tubercular and non tubercular pleural effusions by analyzing cytology, biochemistry and ADA level.Materials & Methods: This study was carried out on 85 patient

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Haefliger, Simon, Julien Rebetez, Paul J. Buser, Stefan Dirnhofer, and Lukas Bubendorf. "Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon." Acta Cytologica 64, no. 3 (2019): 274–78. http://dx.doi.org/10.1159/000502711.

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Emperipolesis is a biological process defined by the presence of an intact cell within the cytoplasm of another cell. In pleural fluid cytology, the phenomenon is very rare but has already been described in B-cell lymphoma. Here, we report the first case of a T-cell lymphoma diagnosed on a pleural fluid exhibiting extensive emperipolesis of tumor cells by mesothelial cells. Additionally, in order to evaluate the prevalence of emperipolesis in lymphocyte rich pleural effusion cytology, we reviewed cases from our archive, including cases with lymphoma and cases with reactive T-lymphocyte rich ef

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Prasad, Dinesh, and Sachin Baleviya. "A rare case of primary pulmonary Hodgkin’s lymphoma." International Surgery Journal 7, no. 8 (2020): 2751. http://dx.doi.org/10.18203/2349-2902.isj20203270.

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A 46 years old male presented with fever, chest pain, dry cough, weight loss, and breathlessness over the preceding 3 months. CT scans of thorax revealed diffuse sclerosis with multiple ill-defined small erosion and pleural thickening of the right lung with bulky lymph node in a subcarinal region measuring approximately 13.5×11×27.5 mm and 20×5 mm soft tissue parenchymal lesion in a right apical zone. Examination of pleural fluid cytology was not diagnostic. Bronchoscopic fluid cytology was also not contributory. Hilar and pre aortic lymph node biopsies showed only reactive change. Video-assis

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Stanzel, Franz. "Thorakozentese als erstes Diagnostikverfahren zur Stratifizierung von Pleuraergüssen bei Patienten mit Verdacht auf eine metastasierte Tumorerkrankung." Kompass Pneumologie 7, no. 2 (2019): 92–93. http://dx.doi.org/10.1159/000496998.

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Background: Thoracentesis with cytological examination of pleural fluid is the initial test of choice for evaluation of pleural effusions in patients with suspected malignant pleural effusion (MPE). There is limited data on the sensitivity of thoracentesis stratified by tumor type. A better understanding of stratified sensitivities is of clinical interest, and may guide early and appropriate referral for pleural biopsy. Objective: The primary objective was sensitivity of thoracentesis with pleural fluid cytology stratified by tumor type. Methods: This is a retrospective cohort study of consecu

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Arnold, David T., Duneesha De Fonseka, Siobhan Perry, et al. "Investigating unilateral pleural effusions: the role of cytology." European Respiratory Journal 52, no. 5 (2018): 1801254. http://dx.doi.org/10.1183/13993003.01254-2018.

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The vast majority of undiagnosed unilateral pleural effusions have fluid sent for cytological analysis. Despite widespread use, there is uncertainty about its sensitivity to diagnose malignant pleural effusions (MPEs). Our aim was to ascertain the utility of cytology using a large prospective cohort.Consecutive patients presenting with an undiagnosed unilateral pleural effusion were recruited to this UK-based study. All had pleural fluid sent for cytological analysis. Cytological sensitivity was based on the final diagnosis at 12 months, confirmed by two consultants.Over 8 years, 921 patients

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Singh, Jyoti, Alok Mohan, Kamna Gupta, Medha Jain, and Anupam Varshney. "CATEGORIZATION OF PLEURAL EFFUSION SPECIMEN ON THE BASIS OF THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY: AN INSTITUTIONAL EXPERIENCE." International Journal of Advanced Research 12, no. 11 (2024): 1437–42. https://doi.org/10.21474/ijar01/19960.

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Background:The International System for Reporting Serous Fluid Cytology (ISRSFC) has been proposed to systemize serous fluid cytopathology reporting and to guide for further clinical management. The present study focused on assessing the feasibility of utilizing ISRSFC reporting categories for pleural fluids, estimating the risk of malignancy (ROM) of each category. Methods: Samples of Pleural effusion sent to cytopathology lab in our institution were evaluated. Cases were categorized into one of the five categories proposed by ISRSFC: Non-diagnostic (ND), Negative for malignancy (NFM), Atypia

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Yasar, Arafath Shaik, and suryakala Dadeboyina. "Study of Etiology of Pleural Effusion in Andhra Pradesh Population." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 826–29. https://doi.org/10.5281/zenodo.11222123.

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<strong>Background:</strong>  Pleural effusion is an excessive accumulation of fluid in the pleural space. It can be a diagnostic dilemma for clinicians because of the multiple etiologies of lung, pleura or systemic disorders.<strong>Material and Methods: </strong>95 patients with newly diagnosed pleural effusion based on Chest – x-ray PA view we’re studied . 20 ml of pleural fluid was aspirated and sent for biochemical, microbiological, and pathological analysis. Echocardiography, USG abdomen, and biopsy of the pleura were carried out in the same patients whose etiology

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Khalbuss, Walid E., Shveta Hooda, and Manon Auger. "Cytomorphology of Boerhaave's syndrome: A critical value in cytology." CytoJournal 10 (April 30, 2013): 8. http://dx.doi.org/10.4103/1742-6413.111811.

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Spontaneous esophageal perforation into the pleural cavity (Boerhaave's syndrome) is a rare life-threatening condition, which requires early diagnosis and urgent management. The diagnosis of such critical condition in many cases is delayed because of atypical clinical presentation, resulting in increased morbidity and mortality. Cytological examination of pleural fluid can provide early, fast and accurate diagnosis of such critical condition and help in better and early management of this disease. We describe a case of an 81-year-old female with esophageal perforation who presented with a left

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Supriya, Siddavatam, MB Lekha, and YA Manjunatha. "Cytomorphological study of body fluids- An attempt to know its role in diagnosis." Panacea Journal of Medical Sciences 14, no. 2 (2024): 415–19. http://dx.doi.org/10.18231/j.pjms.2024.074.

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Body fluid cytology is a routinely performed procedure. It is simple, cost-effective and acts as a first-line investigation in the evaluation of effusions. The inflow and outflow of fluid in the potential spaces of pleural, peritoneal and pericardial cavities is governed by starling forces. In case of tumors, study of effusion cytology helps in the diagnosis and staging process. To study cytomorphology of various body fluids and know their role in diagnosis.The present study is a retrospective descriptive study of 100 cases of various body fluids such as pleural, peritoneal, cerebrospinal and

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Shaik, Imam H., Bindu Gandrapu, Fernando Gonzalez-Ibarra, David Flores, Jyoti Matta, and Amer K. Syed. "Silicone Breast Implants: A Rare Cause of Pleural Effusion." Case Reports in Pulmonology 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/652918.

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Pleural effusions are one of the rarest complications reported in patients with silicone gel filled breast implants. The silicone implants have potential to provoke chronic inflammation of pleura and subsequent pulmonary complications such as pleural effusion. Herein, we report a 44-year-old female who presented with left sided pleural effusion, six weeks after a silicone breast implantation surgery. The most common infectious, inflammatory, and malignant causes of pleural effusion were excluded with pleural fluid cytology and cultures. With recurrent effusion in the setting of recent surgery,

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Pew ND, Hye AQM A, Bari MZJ, et al. "Histomorphological Spectrum of Pleural Biopsy Specimen of Exudative Pleural Effusion in a Tertiary Care Hospital in Bangladesh." Journal of Sylhet Women’s Medical College 12, Number 01 (2022): 36–41. http://dx.doi.org/10.47648/jswmc2022v1201-05.

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Background: The commonest manifestation of pleural pathology is pleural effusion. Most of the time, in spite of routine biochemical and cytological examination of pleural fluid we can’t evaluate the etiology of pleural effusion. Aim: Aim of present study was to make an etiological diagnosis of exudative pleural effusion by pleural biopsy and histopathological examination. Study design and setting: Fifty consecutive patients of pleural effusion were selected from the outpatient and indoor department of a tertiary medical college hospital in Sylhet. It was a prospective and observational study.

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Cohen, Samuel E., Jaime Betancourt, and Guy W. Soo Hoo. "Pleural Uptake Patterns in F18Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) Scans Improve the Identification of Malignant Pleural Effusions." Journal of Clinical Medicine 12, no. 22 (2023): 6977. http://dx.doi.org/10.3390/jcm12226977.

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Background: The confirmation of malignant pleural effusions (MPE) requires an invasive procedure. Diagnosis can be difficult and may require repeated thoracentesis or biopsies. F18Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) can characterize the extent of malignant involvement in areas of increased uptake. Patterns of uptake in the pleura may be sufficient to obviate the need for further invasive procedures. Methods: This is a retrospective review of patients with confirmed malignancy and suspected MPE. Patients who underwent diagnostic thoracentesis with cytology and contemporane

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NDUKWE, CO, ME CHIEMEKA, CC NDUKWE, and CO UKAH. "A Correlation between the Cytology and Histology of Serous Effusions at a Teaching Hospital in South-East Nigeria." Orient J Med 34, no. 3-4 (2022): 65–73. https://doi.org/10.5281/zenodo.6815524.

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<strong>ABSTRACT</strong> <strong>Background:</strong>  Cytological evaluation of body fluids is an important diagnostic test for various malignant and benign conditions. <strong>Objectives</strong>: Our study aims to analyse the various body fluids received in our department over a ten-year period. It also seeks to determine the accuracy and significance of specimen volumes of fluid cytology specimens in diagnosing malignancy in a resource-poor setting. <strong>Methodology:</strong> This is a retrospective study carried out in the Department of Anatomic Pathology of a teaching hospital i

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Anand, Kartik, Shashank Cingam, and Prakash Peddi. "Recurrent Malignant Melanoma Presenting as Isolated Pleural Metastases in a Patient with Chronic Lymphocytic Leukemia." Case Reports in Oncology 10, no. 1 (2017): 86–90. http://dx.doi.org/10.1159/000455827.

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Isolated pleural metastasis with pleural effusion is a rare occurrence in malignant melanoma. We report an unusual case of a patient with chronic lymphocytic leukemia (CLL) and recurrent pleural effusions. The pleural fluid cytology and immunohistochemistry profile were consistent with the diagnosis of CLL. However, chemotherapy with pentostatin, cyclophosphamide, and rituximab did not result in any meaningful clinical response. A video-assisted thoracoscopic surgery and biopsy of the affected nodular parietal layer of the pleura were consistent with malignant melanoma. Our case underlines the

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Grigoruk, O. G., A. F. Lazarev, and L. M. Bazulina. "Diagnostic value of cytologic investigation of cell count differential of pleural fluid." PULMONOLOGIYA, no. 3 (June 28, 2007): 66–71. http://dx.doi.org/10.18093/0869-0189-2007-0-3-66-71.

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The cell count differential of pleural fluid sample is of great importance for estimation of the nature of pleural effusion. In the present article, we compared the efficiencies of routine cytology method with light microscopy, cytological examination with centrifuge Cytospin-4 and immunocytochemical methods. We have studied cytological samples from 1597 patients, with pleural effusion. Effusions associated with malignancies were reported in 22.7 % of patients including carcinomatosis (74.6 %), primary tumors of pleura (21.5 %), effusions associated with non epithelial malignancies (3.9 %). Be

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Akhtar, Kafil, Gowthami Nagendhran, Anjum Ara, and Masheera Akhtar. "Lymphoma presenting as the first finding in pleural fluid cytology: A rare cytologic presentation." IP Archives of Cytology and Histopathology Research 8, no. 4 (2024): 250–52. http://dx.doi.org/10.18231/j.achr.2023.056.

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Malignant hemato-lymphoid neoplasms presenting as the initial finding in pleural effusion cytology is one of the rare challenges a pathologist may encounter in practice among lymphocyte-rich effusions. Meanwhile, effusion cytology is an easily available, inexpensive diagnostic tool in our setting. Cytomorphological features provide crucial insights into the nature of the disease, which along with immunocytochemistry may help in solidifying the diagnosis. Here we present a rare case of a 17-year-old patient, who initially presented with pleural effusion that turned out to be lymphoma on cytolog

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Momin, Majed Abdul Basit. "LE (lupus erythematosus) Cell in Pleural fluid Cytology." Journal of Bangladesh College of Physicians and Surgeons 41, no. 4 (2023): 348–49. http://dx.doi.org/10.3329/jbcps.v41i4.68983.

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During the COVID-19 (coronavirus disease) pandemic, a middle-aged woman was brought to the emergency department after experiencing sudden difficulty breathing after a two-week history of fever and cough. A contrast-enhanced computerised tomography (CECT) scan revealed minimal pericardial and pleural effusions on the left side. A pleural effusion was tapped using ultrasound guidance and sent to the cytopathology laboratory. A cytological examination revealed numerous lupus erythematosus (LE) cells, resulting in a diagnosis of lupus pleuritis. J Bangladesh Coll Phys Surg 2023; 41(4): 348-349

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Manish, Kumar Bhaskar, Kumar Sunil, Prakash Jaiswal Chand, Kumar Shah Pawan, and Gupta Aashish. "Diagnostic accuracy of exudative pleural fluid cytology with the correlation of gene xpert in Tuberculosis." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 487–95. https://doi.org/10.5281/zenodo.14593209.

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<strong>Background:</strong> Pleural fluid is categorised as either transudate or exudate based on modified Light’s criteria.  Pleural effusion is classified as an exudative effusion if at least one of the criteria is met. Pleural fluid protein/serum protein ratio of greater than 0.5. Pleural fluid lactate dehydrogenase (LDH)/serum LDH ratio of greater than 0.6. Pleural fluid lactate dehydrogenase (LDH) is greater than 2/3rd of the upper limit of normal value for serum lactate dehydrogenase (LDH). <strong>Materials and Methods</strong>: A prospective study was conducted ov

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Biswas, Biswajit, SudarshanKumar Sharma, RameshwarSingh Negi, et al. "Pleural biopsy: A superior procedure than pleural fluid cytology in diagnosing pleural malignancy." Clinical Cancer Investigation Journal 4, no. 4 (2015): 530. http://dx.doi.org/10.4103/2278-0513.158457.

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MacRosty, Christina R., Amber Wright, Agathe Ceppe, Sohini Ghosh, A. Cole Burks, and Jason A. Akulian. "Pleural Fluid Resolution Is Associated with Improved Survival in Patients with Malignant Pleural Effusion." Life 13, no. 5 (2023): 1163. http://dx.doi.org/10.3390/life13051163.

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Malignant pleural effusion is associated with a poor prognosis and, while risk stratification models exist, prior studies have not evaluated pleural fluid resolution and its association with survival. We performed a retrospective review of patients diagnosed with malignant pleural effusion between 2013 and 2017, evaluating patient demographics, pleural fluid and serum composition, and procedural and treatment data using Cox regression analysis to evaluate associations with survival. In total, 123 patients were included in the study, with median survival from diagnosis being 4.8 months. Resolut

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Balakrishnan, Meera, Smiley Annie George, Anupama Arora Mallik, and Mrinmay Kumar Mallik. "Effusion Cytology of Dysgerminoma: A Case Report with Review of Literature." Annals of Pathology and Laboratory Medicine 10, no. 7 (2023): C89–93. http://dx.doi.org/10.21276/apalm.3261.

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Ovarian dysgerminoma is a rare malignant ovarian germ cell tumor (MOGT) with its peak incidence in women younger than 20 years. Peritoneal and pleural dissemination of ovarian tumors is a major prognostic parameter in ovarian malignancies. Effusion cytology of germ cell tumors are not frequently reported in the literature. We report a case of a MOGT in a 15 year old female who presented with severe painful abdominal distention and respiratory distress. Ascitic and pleural fluid cytology were positive for malignant cells which on immunocytochemistry supported the diagnosis of metastatic dysgerm

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Shreenivas, Aditya V., Massimo Cristofanilli, Sewanti Atul Limaye, et al. "Molecular profiling of body fluid cfDNA: Advancing diagnostics and therapeutic decisions." Journal of Clinical Oncology 43, no. 16_suppl (2025): 3054. https://doi.org/10.1200/jco.2025.43.16_suppl.3054.

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3054 Background: Effusions in cancer patients pose several critical challenges for clinicians. In known cancer patients, an effusion may signal recurrence, whereas in newly diagnosed, seemingly localized cases, it indicates a more advanced stage. In many patients the effusion may be secondary to complications of treatment or comorbidities, rather than malignant. Diagnosing malignant involvement of body fluids remains a challenge due to the limitations of conventional cytology. This study explores the potential of molecular profiling of body fluids to identify actionable molecular alterations a

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Eva Sri Ayu Tarigan. "Description Of The Results Of The Cytological Examination Of Pleural Fluid Using Giemsa Staining." MEDISTRA MEDICAL JOURNAL (MMJ) 1, no. 1 (2023): 7–12. http://dx.doi.org/10.35451/mmj.v1i1.1944.

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Many objects after being fixed and then glued with entellan or balsam become so transparent that their structure is not obvious when viewed with a microscope. To overcome this difficulty, in general, preparations are colored with dyes that can clarify their structure. Staining aims to sharpen or clarify various tissue elements, especially the cells, so that they can be distinguished and studied under a microscope. This research was conducted at the Anatomical Pathology Laboratory of Grandmed Lubuk Pakam Hospital in February 2020 - July 2020. The research design was descriptive. The population

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Domfeh, Akosua B., Laurentia Nodit, Joel F. Gradowski, and Sheldon Bastacky. "Mycobacterium kansasii Infection Diagnosed by Pleural Fluid Cytology." Acta Cytologica 51, no. 4 (2007): 627–30. http://dx.doi.org/10.1159/000325813.

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Maharjan, Sushana, Sabin Ranabhat, Mamata Tiwari, Anita Bhandari, Bidur Prasad Osti, and Puja Neopane. "Exfoliative cytology analysis from different sites of the body." Journal of Chitwan Medical College 7, no. 2 (2017): 33–39. http://dx.doi.org/10.3126/jcmc.v7i2.23674.

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Background: Cytological study of body fluids a non-invasive, simple procedure, relatively inexpensive, and helps in faster reporting that has high population acceptance. The present study aims to determine the proportion of malignant and non malignant lesions. Methods: A total of 1129 specimens of exfoliative cytology were examined during the period over five years from year January 2011 to December 2016 at Department of Pathology at Chitwan Medical College Teaching Hospital, Nepal. The fluid received was centrifuged at 3000 revolutions per minute for five minutes. Smears were made from

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Singh, Yogesh Kumar, Shubhangee Arya, Jayati Tripathi, Sonali Bandil, Shruti Singh, and Naushad Husain. "A Clinicopathological Study of Pleural Effusion at ASMC, Firozabad." International Journal of Pharmaceutical and Clinical Research 16, no. 9 (2024): 612–15. https://doi.org/10.5281/zenodo.13906450.

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<strong>Background:</strong>  Pleural effusion is an excessive accumulation of fluid in the pleural space  . Pleural effusion is not a disease entity per se rather it’s a manifestation of a complication of the pulmonary or non-pulmonary diseases. The causes of Pleural Effusion are too many. Pleural fluid analysis by cytology and cell block remain the mainstays for diagnosing etiology of pleural effusion. <strong>Objectives: </strong>This study aimed to perform cytological analysis of pleural fluid to find out its etiology and to find prevalence of these etiologies wit

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Gulyas, Miklos, Janos Fillinger, Andras D. Kaposi, and Miklos Molnar. "Use of cholesterol and soluble tumour markers CEA and syndecan-2 in pleural effusions in cases of inconclusive cytology." Journal of Clinical Pathology 72, no. 8 (2019): 529–35. http://dx.doi.org/10.1136/jclinpath-2018-205650.

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AimsIn order to improve diagnostics in pleural effusions, additional value of effusion cholesterol, carcinoembryonic antigen (CEA) and syndecan-2 assays to cytology was studied.MethodsBiomarkers were measured in effusion supernatants from 247 patients, of whom 126 had malignant pleural involvement, and their additional diagnostic efficacy to cytology was assessed.ResultsSyndecan-2 measurement, although gave detectable concentrations in all effusions with highest median value in mesotheliomas, was non-discriminative between different pathological conditions. CEA concentrations exceeding 5 ng/mL

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Toprak, M., J. Lanceta, and O. C. Rosca. "Merkel Cell Carcinoma Presenting as a Malignant Pleural Effusion Post-COVID-19 Hospitalization: a Case Report and Literature Review." American Journal of Clinical Pathology 156, Supplement_1 (2021): S38—S39. http://dx.doi.org/10.1093/ajcp/aqab191.076.

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Abstract Introduction/Objective Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine carcinoma of the skin, associated with immunosuppression, UV light exposure, and the Merkel cell polyomavirus (MCPyV). Metastatic MCC diagnosed in body fluid cytology is extremely rare. Here, we report on a case of a 65-year-old male presenting with a right pleural effusion and a remote history of MCC, unknown to us during the cytologic evaluation of the effusion. To the best of our knowledge, this is the sixth case of metastatic MCC diagnosed in body fluid cytology reported in English liter

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