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Journal articles on the topic 'Pleural fluid lymphocyte count'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Verma, Akash, Rucha S. Dagaonkar, Dominic Marshall, John Abisheganaden, and R. W. Light. "Differentiating Malignant from Tubercular Pleural Effusion by Cancer Ratio Plus (Cancer Ratio: Pleural Lymphocyte Count)." Canadian Respiratory Journal 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7348239.

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Background. We performed prospective validation of the cancer ratio (serum LDH : pleural ADA ratio), previously reported as predictive of malignant effusion retrospectively, and assessed the effect of combining it with “pleural lymphocyte count” in diagnosing malignant pleural effusion (MPE).Methods. Prospective cohort study of patients hospitalized with lymphocyte predominant exudative pleural effusion in 2015.Results. 118 patients, 84 (71.2%) having MPE and 34 (28.8%) having tuberculous pleural effusion (TPE), were analysed. In multivariate logistic regression analysis, cancer ratio, serum L

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Singgih, Venny, Ketut Suryana, Ida Ayu Jasminarti Dwi Kusumawardani, Ni Wayan Candrawati, I. Gede Ketut Sajinadiyasa, and Ida Bagus Ngurah Rai. "Role of pleural fluid interleukin-6, neutrophil-lymphocyte ratio, and monocyte-lymphocyte ratio in distinguishing tuberculous and malignant pleural effusions." International Journal of Advances in Medicine 8, no. 4 (2021): 492. http://dx.doi.org/10.18203/2349-3933.ijam20211046.

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Background: Pleural effusion is caused by various disease, including tuberculosis infection and malignancy. To determine the etiology, immunologic parameters are needed to distinguish tuberculous and malignant pleural effusions, including pleural fluid interleukin-6 (IL-6), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR).Methods: This was a cross-sectional study, conducted at Sanglah General Hospital in Denpasar from March 2020 to September 2020. Pleural fluid IL-6 and leucocyte differential count were measured from subjects with tuberculous and malignant pleural effusio

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International, Journal of Medical Science and Innovative Research (IJMSIR). "A Cross Sectional Study to Determine The Efficacy of Serum LDH: Pleural Fluid Ada Ratio As A Biomarker of Malignant Pleural Effusion in IRD, SMS Medical College, Jaipur." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 4 (2024): 151–58. https://doi.org/10.5281/zenodo.15422923.

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<strong>Abstract</strong> <strong>Introduction</strong>: The malignant pleural effusion is one of the most common causes of exudative pleural effusion. There is no accurate and commonly accepted biochemical marker of MPE, hence using common parameters two ratio serum LDH: pleural fluid ADA (cancer ratio) and cancer ratio: pleural fluid lymphocyte count (cancer ratio plus) derived and their efficacy in identification of MPE is studied. <strong>Methods</strong>: 60 undiagnosed pleural effusion patients were studied in a hospital based cross sectional observational analytical study. The values of

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Popowicz, Natalia, Hui Min Cheah, Cynthia Gregory, et al. "Neutrophil-to-lymphocyte ratio in malignant pleural fluid: Prognostic significance." PLOS ONE 16, no. 4 (2021): e0250628. http://dx.doi.org/10.1371/journal.pone.0250628.

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Predicting survival of patients with malignant pleural effusions (MPEs) is notoriously difficult. A robust prognostic marker can guide clinical decision making. The neutrophil-to-lymphocyte ratio (NLR) in blood has been shown to predict survival in many cancers. Pleural fluid bathes the malignant pleural tissues, thus the NLR of the pleural fluid may reflect more closely the local tumour environment. The objective of this study was to explore the prognostic significance of pleural effusion NLR for MPE. We analysed matched effusion and blood from 117 patients with malignant and 24 with benign p

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Chaturvedi, Shweta, Gajendra Nath Gupta, Mansi Faujdar, Rohit Jain, and Rateesh Sareen. "Body fluid analysis by 'Automated' Sysmex XN 1000 – The way ahead." International Journal of Clinicopathological Correlation 8, no. 1 (2024): 22–28. http://dx.doi.org/10.56501/intjclinicopatholcorrel.v8i1.1075.

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Body fluids are those excreted or secreted from the body. In the laboratory, the use of the term “body fluids” designates a category that excludes blood and urine. Determining the etiologic cause of fluid accumulation in various body cavities (i.e., joints, chest, and abdomen) is critical for proper treatment of various disorders. To evaluate the correlation and agreement of leucocyte and erythrocyte count in body fluids among Improved Neubauer Chamber and automated method using Sysmex XN-1000 body fluid module. A total of 500 routinely collected body fluid samples (CSF, ascitic fluid, pericar

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Agarwal, Abhishek, Ahbab Hussain, Rajendra Prasad, Anand Verma, Amitabh Banka, and Tasleem Raza. "The advantage of PCR for MTB in comparison to ADA in diagnosing tubercular pleural effusion." International Journal of Advances in Medicine 5, no. 1 (2018): 131. http://dx.doi.org/10.18203/2349-3933.ijam20180071.

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Background: Tuberculosis continues to be an important health problem globally. The bacteriological confirmation of diagnosis in extrapulmonary tuberculosis patients is more difficult because most of the cases of extrapulmonary tuberculosis are paucibacillary in nature. In this study we have compared the pleural fluid ADA levels with PCR for MTB in pleural fluid to confirm the diagnosis of tuberculosis in the pleural fluid.Methods: The study was done over two years and a total of 106 patients with a clinico-radiological diagnosis of pleural effusion were enrolled for the study. The pleural flui

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Meryem, Fettah, Mimouni Mohamed, Alaoui Othmane, Mahmoudi Abdelhalim, Khattala Khalid, and Bouabdallah Youssef. "Recurrent Idiopathic Chylothorax in Children: A Case Report." SAS Journal of Surgery 10, no. 05 (2024): 616–21. http://dx.doi.org/10.36347/sasjs.2024.v10i05.021.

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Chylothorax is a rare disease (1-2% of pleural effusions), with a prevalence between 1/8600 and 1/15,000 births. It is characterized by the presence of chyle in the pleural cavity. Three categories of chylothorax are known: congenital, idiopathic or traumatic (usually postoperative) chylothorax. We report the observation of a 3-year-old child with idiopathic chylothorax revealed by respiratory symptoms, with pleural effusion and ipsilateral lung collapse on chest x-ray and CT. Cytology and chemical analysis of pleural fluid showed exudative fluid with a chyous appearance, high cell count (2800

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8

Ganesan, Natesh, Prasanth Gururaj, and Gangadharan Vadivelu. "Cholesterol pleurisy: a rare complication of tuberculosis." International Journal of Research in Medical Sciences 10, no. 11 (2022): 2689. http://dx.doi.org/10.18203/2320-6012.ijrms20222884.

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Pseudochylothorax (PCT) is a rare form of pleural effusion and is characterized by high cholesterol content and milky pleural fluid. Common causes include tuberculosis, rheumatoid arthritis, paragonimiasis, echinococcosis and neoplasia. A 27-year-old male presented with breathlessness for past 3 years aggravated for past 2 months, swelling in perianal region for 6 months with history of treatment for pulmonary tuberculosis with recurrent left pleural effusion for which intercostal drain (ICD) was inserted. Blood investigations showed elevated total leukocyte count and ESR. Radiological investi

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Garcia-Zamalloa, Alberto, Diego Vicente, Rafael Arnay, et al. "Diagnostic accuracy of adenosine deaminase for pleural tuberculosis in a low prevalence setting: A machine learning approach within a 7-year prospective multi-center study." PLOS ONE 16, no. 11 (2021): e0259203. http://dx.doi.org/10.1371/journal.pone.0259203.

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Objective To analyze the performance of adenosine deaminase in pleural fluid combined with other parameters routinely measured in clinical practice and assisted by machine learning algorithms for the diagnosis of pleural tuberculosis in a low prevalence setting, and secondly, to identify effusions that are non-tuberculous and most likely malignant. Patients and methods We prospectively analyzed 230 consecutive patients diagnosed with lymphocytic exudative pleural effusion from March 2013 to June 2020. Diagnosis according to the composite reference standard was achieved in all cases. Pre-test p

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Patel, Bhavesh H., Kathryn H. Melamed, Holly Wilhalme, et al. "Implications of Pleural Fluid Composition in Persistent Pleural Effusion following Orthotopic Liver Transplant." Medical Sciences 11, no. 1 (2023): 24. http://dx.doi.org/10.3390/medsci11010024.

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Persistent pleural effusions (PPEf) represent a known complication of orthotopic liver transplant (OLT). However, their clinical relevance is not well described. We evaluated the clinical, biochemical, and cellular characteristics of post-OLT PPEf and assessed their relationship with longitudinal outcomes. We performed a retrospective cohort study of OLT recipients between 2006 and 2015. Included patients had post-OLT PPEf, defined by effusion persisting >30 days after OLT and available pleural fluid analysis. PPEf were classified as transudates or exudates (ExudLight) by Light’s criteria.

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Ahmed, Jamal Uddin, Mohammad Delwar Hossain, Farhana Afroz, Muhammad Abdur Rahim, and AKM Musa. "Role of Pleural Biopsy in the Etiological Diagnosis of Exudative Pleural Effusion." Bangladesh Critical Care Journal 5, no. 1 (2017): 33–36. http://dx.doi.org/10.3329/bccj.v5i1.32540.

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Purpose: Exudative pleural effusion usually indicates an underlying pulmonary pathology. Sometimes etiological diagnosis of exudative pleural effusion is difficult despite cytological, biochemical and microbiological tests. Aim of present study was to make an etiological diagnosis of exudative pleural effusion by pleural biopsy.Methods: This cross-sectional observational study was performed from January 2012 to December 2014 in the Department of Internal Medicine & Pulmonology of BIRDEM General Hospital, Dhaka, Bangladesh. A total of 51 patients with exudative pleural effusion in whom the

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Kurmi, Roshan, Anand Chaurasiya, Sudhakar Jha, and Sanjay Kumar Sah. "A Study of Tuberculous Pleural Effusion in Province 2, Southern Nepal." Med Phoenix 8, no. 2 (2023): 61–65. http://dx.doi.org/10.3126/medphoenix.v8i2.61508.

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Introduction: Tuberculosis (TB) is a major public health problem in developing countries. Tuberculous pleural effusion is the second most common form of extrapulmonary tuberculosis (TB) (after lymphatic involvement) and is the most common cause of pleural effusion in areas where TB is endemic. The aim of this study is to depict the pattern of the Tuberculous Pleural Effusion (TPE) with its clinical presentation and diagnosis along with the different laboratory parameters of the TB patients at a tertiary care center of the Southern Nepal. Materials and Methods: A prospective hospital based cros

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Manish, Kumar Bhaskar, Kumar Sunil, Prakash Jaiswal Chand, Kumar Shah Pawan, and Gupta Aashish. "Diagnostic accuracy of exudative pleural fluid cytology with the correlation of gene xpert in Tuberculosis." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 487–95. https://doi.org/10.5281/zenodo.14593209.

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<strong>Background:</strong> Pleural fluid is categorised as either transudate or exudate based on modified Light’s criteria.  Pleural effusion is classified as an exudative effusion if at least one of the criteria is met. Pleural fluid protein/serum protein ratio of greater than 0.5. Pleural fluid lactate dehydrogenase (LDH)/serum LDH ratio of greater than 0.6. Pleural fluid lactate dehydrogenase (LDH) is greater than 2/3rd of the upper limit of normal value for serum lactate dehydrogenase (LDH). <strong>Materials and Methods</strong>: A prospective study was conducted ov

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Jain, Anant, Anusha Devarajan, Hussein Assallum, Ramin Malekan, Gregg M. Lanier, and Oleg Epelbaum. "Characteristics of early pleural effusions after orthotopic heart transplantation: comparison with coronary artery bypass graft surgery." Pleura and Peritoneum 6, no. 4 (2021): 161–65. http://dx.doi.org/10.1515/pp-2021-0143.

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Abstract Objectives Pleural effusions appearing within the first 30 postoperative days following coronary artery bypass grafting (CABG) are classified as early and believed to be directly related to the surgery. The characteristics of such effusions are well-described. Orthotopic heart transplantation is also known to be complicated by pleural effusions; however, their characteristics have not been systematically reported. We assessed the features of early postoperative pleural effusions after heart transplantation and compared them to those of early effusions following CABG. Methods We retros

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Swamy, GG, TMV Prasada Rao, P. Sunitha, and S. Madhuravani. "Role of pleural fluid analysis in establishing the diagnosis of pleural effusion Experience in College of Medical Sciences-Teaching Hospital, Bharatpur, Nepal." Journal of College of Medical Sciences-Nepal 6, no. 4 (2012): 36–45. http://dx.doi.org/10.3126/jcmsn.v6i4.6724.

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Aspiration of serous cavities is a simple and relatively non-invasive technique to achieve a diagnosis. The information provided by body fluid analysis serves several functions; it is a complete diagnostic modality which aims at pointing out the etiology of effusion as well as in certain cases, a means of prognostication of the disease process. The diagnostic performance of the cytological study of the fluid may be attributable to the fact that the cell population present in sediment. Thus, this study was aimed to assess the role of pleural fluid analysis in establishing the cause of pleural e

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Shagdaleev, R. F., E. A. Toneev, A. A. Martynov, M. A. Belova, and A. D. Teryagova. "Prognostic model and calculator for assessing the risk of prolonged pleural effusion after lobectomy." Pirogov Russian Journal of Surgery, no. 6 (June 2, 2025): 26. https://doi.org/10.17116/hirurgia202506126.

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Objective. To develop a nomogram and risk assessment calculator for prolonged pleural effusion after lobectomy for lung cancer. Material and methods. The study was conducted at the Thoracic Oncology Surgery Department of the Ulyanovsk Regional Oncology Dispensary. Patients who underwent lobectomy between January 1, 2022 and January 1, 2024 were included (database registration state No. 2024622456). There were 78 patients including 48 ones without prolonged pleural effusion (PPE) and 30 ones with this complication. After statistical analysis, data bootstrapping and logistic regression calibrati

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Shaheduzzaman, AKM, Devendra Nath Sarkar, Md Ferdous Wahid, et al. "Role of pleural biopsy in diagnosis of unilateral pleural effusion:study of 50 cases in Rangpur Medical College & Hospital, Rangpur." Bangladesh Journal of Medicine 27, no. 2 (2016): 62–67. http://dx.doi.org/10.3329/bjmed.v27i2.29051.

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Background: Pleural effusion remains the most common manifestation of pleural pathology. Sometime it is difficult to differentiate between tuberculous and malignant pleural effusion on routine cytological and biochemical examination. So pleural biopsy is an important tool for evaluating undiagnosed pleural effusion.Aim: To find out the role of pleural biopsy in the diagnosis of unilateral pleural effusion.Methods: This observational study was conducted in the Indoor patient department of Medicine in Rangpur Medical College Hospital from 01.01.2014 to 30.06.2014. All patients having unilateral

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González, Alejandra, Mariano Fielli, Adrián Ceccato, and Carlos Luna. "Score for Differentiating Pleural Tuberculosis from Malignant Effusion." Medical Sciences 7, no. 3 (2019): 36. http://dx.doi.org/10.3390/medsci7030036.

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Differential diagnosis of lymphocytic pleural effusions between tuberculous (TBE) and malignant (ME) effusion is usually difficult in daily practice. Our aim was to develop a score to differentiate TBE from ME effusions. A cohort of 138 consecutive patients with pleural effusion was prospectively studied from May 2014 through June 2017. Glucose, lactate dehydrogenase (LDH), proteins, white cell count, lactic acid, and pH in the pleural fluid were measured. Pleural effusions other than lymphocytic, patients with a final diagnosis other than tuberculosis or malignancy, and patients who met Light

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Wirk, Baldeep. "Massive Pleural Effusions and Anasarca After Allogeneic Hematopoietic Cell Transplantation." Blood 116, no. 21 (2010): 4556. http://dx.doi.org/10.1182/blood.v116.21.4556.4556.

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Abstract Abstract 4556 A 37 year old male with T cell acute lymphoblastic leukemia with normal cytogenetics 46XY in second complete remission (CR2) after 8 cycles of HyperCVAD and 4 cycles of salvage nelarabine underwent myeloablative conditioning with cyclophosphamide TBI for a matched related donor allogeneic stem cell transplant from his brother. His day+100 bone marrow biopsy showed CR2 and was 100% donor. His post transplant course was unremarkable until he relapsed d+162. The immunosuppression was tapered off rapidly and 2 cycles of nelarabine and a donor lymphocyte infusion (1×107 CD3 c

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Desai, Vishal K., and Rashmi S. Arora. "Profile of exudative pleural effusion in the region of Bhuj people." International Journal of Advances in Medicine 5, no. 4 (2018): 1057. http://dx.doi.org/10.18203/2349-3933.ijam20183147.

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Background: Exudative pleural effusions are a common diagnostic problem in clinical practice, as the list of causes is quite exhaustive, although sometimes they can be inferred from the clinical picture. In the West the most common cause is Para pneumonic effusions followed by malignancy, while in India it is tubercular effusion followed by malignant effusion. Despite the availability of various tests, there is a need for deﬁning the best diagnostic and cost-effective approach to quickly diagnose and treat exudative pleural effusions. The objectives are to conduct a clinical and etiological st

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Dayanand, Prasad, Kumar Rajnish, Kumar Sunil, Kumari Sarbil, and Krishna Sahay Yogesh. "Investigation of Adenosine Deaminase Activity in Tuberculosis Pleural Effusion." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 1100–1104. https://doi.org/10.5281/zenodo.11284845.

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<strong>Background:</strong> Adenosine deaminase is an enzyme found in T lymphocytes that increases in the pleural fluid due to the cell-mediated immune response towards mycobacterium. In this study, the role of adenosine deaminase activity as a biomarker is assessed for the diagnosis of tubercular pleural effusion. <strong>Methods:</strong> 200 participants are studied in this study at BMIMS, Bihar, India. They were divided into two groups, the control group and the group with diagnosis of tuberculosis. Blood samples and pleural effusion were evaluated for haemoglobin levels, t

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Kankananarachchi, I., K. K. S. Priyankara, K. K. K. Lakman, K. Withanaarachchi, and P. K. G. Gunathilaka. "Two Cases of Congenital Chylethorax: A Successful Story of Medical Management." Case Reports in Pediatrics 2021 (August 7, 2021): 1–4. http://dx.doi.org/10.1155/2021/6634326.

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Congenital chylothorax (CC) is one of the most common causes of pleural effusions in neonates. Associated ipsilateral pulmonary aplasia in CC results in neonatal respiratory distress. Here, we report 2 cases of CC who were managed in the Teaching Hospital Karapitiya, Sri Lanka, between 2017 and 2019. Both babies were males who presented with respiratory distress within a few hours of birth. Their antenatal ultrasound scans failed to detect CC. Chest radiographs showed left-sided pleural effusions. Pleural fluid was milky yellowish suggestive of chylothorax, and the analysis revealed elevated t

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Pietro Sartorelli, Sveva Indini, Francesco Bianchi, et al. "Cytological analysis of bronchoalveolar lavage fluid in asbestos-exposed workers: BALF features in asbestos exposed workers." La Medicina del Lavoro 111, no. 5 (2020): 379–87. https://doi.org/10.23749/mdl.v111i5.9170.

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Background: Asbestos-related lung diseases are a group of heterogeneous disorders with different pathogenesis and prognosis. Very few studies investigated the BALF cell profile of asbestos exposed workers. The existence of a relationship between bronchoalveolar lavage fluid (BALF) cellular pattern and specific diagnosis and/or asbestos exposure biomarkers would allow the identification of effect biomarkers useful in the follow up of asbestos-exposed workers and in the diagnosis of asbestos-related diseases. Objectives: To assess BALF cell profile in formerly asbestos-exposed workers and its re

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Porkka, Kimmo, Michele Baccarani, Andreas Hochhaus, et al. "Occurrence, Management, and Outcomes In Patients with Pleural Effusion During Dasatinib Treatment for Chronic-Phase Chronic Myeloid Leukemia (CML-CP) In the First-Line Setting: Analysis of the DASISION Trial." Blood 116, no. 21 (2010): 2282. http://dx.doi.org/10.1182/blood.v116.21.2282.2282.

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Abstract Abstract 2282 Background: The Phase 3 DASISION trial comparing dasatinib 100 mg once daily with imatinib 400 mg once daily as initial treatment in patients (pts) with newly diagnosed CML-CP has demonstrated superior efficacy and favorable safety of dasatinib after a minimum of 12 months of follow-up (Kantarjian, H, et al. N Engl J Med 2010;362:2260). While fluid retention was more frequent with imatinib than with dasatinib, pleural effusion was seen only with dasatinib. Here, we provide a detailed analysis of pts experiencing pleural effusion, a clinically relevant adverse drug reacti

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Tabe, Yoko, Hiroyuki Takemura, Konobu Kimura, et al. "Novel Flowcytometry-Based Approach for Detection of Tumor Cells in Body Fluid Using Automated Hematology Analyzer." Blood 126, no. 23 (2015): 5600. http://dx.doi.org/10.1182/blood.v126.23.5600.5600.

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Abstract Introduction: Nucleated cells differential analysis of body fluid (BF) samples is important diagnostic tool for several diseases including cancer metastasis. Detection of tumor cells in BF requires the manual morphological scanning of slides by the cytopathologists, which is time-consuming, labor-intensive and not always reliable because of a relatively low overall sensitivity rates (ranging 40-90%) with the higher false-negative rates for lymphomas and mesotheliomas. This study aimed to develop the scattergram gating analysis for detection of tumor cells in BF using the automated hem

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Raznatovska, О. М., V. I. Petrenko, O. S. Shalmin, et al. "Difficulties in Diagnosing of Pancreatic Cancer in HIV Infection with Generalised Lymphadenopathy: Tuberculosis, Non-Tuberculosis Mycobacterial Infection or Metastases (Clinical Case)." Tuberculosis, Lung Diseases, HIV Infection, no. 1 (February 29, 2024): 78–85. http://dx.doi.org/10.30978/tb2024-1-78.

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Our observation of the pancreatic cancer diagnosing difficulties in a patient with HIV infection with generalised lymphadenopathy is presented. The patient’s HIV infection was diagnosed 8 months before hospitalisation, he did not receive antiretroviral therapy. He came to the doctor already in a serious condition, when severe intoxication syndrome, weight loss, abdominal pain radiating to the lower back and diarrhea were noted. The patient was hospitalised in a serious condition, where he spent 42 days. The patient had severe immunosuppression since hospitalisation time (CD4+ lymphocyte count

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Lucivero, G., G. Pierucci, and L. Bonomo. "Lymphocyte subsets in peripheral blood and pleural fluid." European Respiratory Journal 1, no. 4 (1988): 337–40. http://dx.doi.org/10.1183/09031936.93.01040337.

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We have examined the distribution of B and T lymphocytes, T-cells with helper/inducer (T4+) or suppressor/cytotoxic (T8+) phenotypes and a subset of cells with natural killer (NK) activity and positive for the Leu 7 (HNK-1) surface antigen in peripheral blood and in lymphocyte-rich pleural effusions of patients with tuberculosis or malignancies (mesothelioma and lung cancer with pleural metastasis). In individual patients, the percentages of T lymphocytes were uniformly higher in pleural effusions than in peripheral blood; however, lower percentages of B lymphocytes and cells positive for the

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Bose, Indraneel, Jaydip Deb, Shilpi Adhikary, and Dibyendu Saha. "Diagnostic accuracy of combined pleural fluid adenosine deaminase and lymphocyte-to-neutrophil ratio versus CBNAAT/TrueNat in suspected tubercular pleural effusion patients." Journal of Association of Chest Physicians 13, no. 2 (2025): 47–50. https://doi.org/10.4103/jacp.jacp_19_24.

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Background: Although rapid cartridge- and chip-based assays such as CBNAAT and TrueNat provide precise and timely diagnosis of tubercular pleural effusion, their sensitivity in immunocompetent individuals remains lower than that of other pleural fluid markers. In a high-tuberculosis (TB)-prevalence regions, markedly elevated pleural fluid adenosine deaminase (ADA) combined with strong clinical suspicion can justify treatment initiation. In low-prevalence areas, ADA retains a high negative predictive value (NPV) but its positive predictive value declines. By contrast, the combined use of pleura

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Haefliger, Simon, Julien Rebetez, Paul J. Buser, Stefan Dirnhofer, and Lukas Bubendorf. "Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon." Acta Cytologica 64, no. 3 (2019): 274–78. http://dx.doi.org/10.1159/000502711.

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Emperipolesis is a biological process defined by the presence of an intact cell within the cytoplasm of another cell. In pleural fluid cytology, the phenomenon is very rare but has already been described in B-cell lymphoma. Here, we report the first case of a T-cell lymphoma diagnosed on a pleural fluid exhibiting extensive emperipolesis of tumor cells by mesothelial cells. Additionally, in order to evaluate the prevalence of emperipolesis in lymphocyte rich pleural effusion cytology, we reviewed cases from our archive, including cases with lymphoma and cases with reactive T-lymphocyte rich ef

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Barnes, P. F., S. D. Mistry, C. L. Cooper, C. Pirmez, T. H. Rea, and R. L. Modlin. "Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis." Journal of Immunology 142, no. 4 (1989): 1114–19. http://dx.doi.org/10.4049/jimmunol.142.4.1114.

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Abstract The study of T lymphocytes from pleural fluid and tissue of patients with tuberculous pleuritis provides an opportunity to evaluate the human immune response to infection at the site of disease activity. Therefore, we investigated the phenotype and function of CD4+ pleural fluid cells from patients with tuberculous pleuritis. Pleural fluid was enriched with CD4+CDw29+ T lymphocytes, which are thought to represent "memory" T cells. Immunoperoxidase staining of pleural tissue confirmed the predominance of CD4+CDw29+ T lymphocytes at the site of disease activity. CD4+ subpopulations were

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Malempati, Uma D., and Kusuma K. Medooru. "Evaluation of adenosine deaminase activity in serum and pleural fluid of pulmonary tuberculosis patients with pleural effusion." International Journal of Research in Medical Sciences 6, no. 10 (2018): 3358. http://dx.doi.org/10.18203/2320-6012.ijrms20184046.

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Background: In endemic regions, a high adenosine deaminase (ADA) activity in lymphocyte predominant exudate is a valuable adjunct in diagnostic evaluation and treatment initiation in tuberculous pleural effusion. Tuberculosis is highly endemic in India, requiring prompt diagnosis, effective treatment and control of the disease. The present study was aimed to evaluate the serum and pleural fluid ADA activities in pulmonary tuberculosis patients with pleural effusion.Methods: This study includes a total of 240 subjects; 40 pulmonary tuberculosis patients (PTB), 40 PTB with pleural effusion (PE),

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Chalamalasetty, Sai Pooja, Preetam Acharya, Thomas Antony, Anand Ramakrishna, and Himani Kotian. "The Use of “Cancer Ratio” in Differentiating Malignant and Tuberculous Pleural Effusions: Protocol for a Prospective Observational Study." JMIR Research Protocols 13 (December 23, 2024): e56592. https://doi.org/10.2196/56592.

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Background Differentiating between tuberculosis and malignancy as the cause of an exudative lymphocyte predominant pleural effusion is difficult due to similarities in the cellular and biochemical characteristics of the pleural fluid in both conditions. Microbiological tests in tubercular pleural effusions have a poor diagnostic yield, and the long turnaround time for results prevents an early diagnosis. The diagnosis of malignant pleural effusion (MPE) is hampered by a variable yield of pleural fluid cytology and closed pleural biopsy and the fact that thoracoscopy may not be readily availabl

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Goseva, Zlatica, Biserka Jovkovska Kaeva, Angelko Gjorcev, et al. "Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Etiology." Open Access Macedonian Journal of Medical Sciences 4, no. 1 (2015): 50–53. http://dx.doi.org/10.3889/oamjms.2016.009.

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BACKGROUND: The proportion of T and B lymphocytes in pleural fluids and blood may point to the presence of local immunological phenomena in pleural disorders.AIM: Aim of study was to evaluate the lymphocyte phenotype and the ratio between helper (CD4+) and cytotoxic/suppressor (CD8+) lymphocytes in malignant and non-malignant effusions.MATERIAL AND METHODS: We studied 48 patients with pleural effusions. First group had 18 patients with tuberculosis pleural effusions; second group had 20 patients with malignant pleural fluids, third group had 10 patients with transudates and 30 healthy controls

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Paul, Susanta Kumar, Shamim Ahmed, Rajashish Chakrabortty, et al. "Usefulness of pleural fluid cholesterol in the diagnosis of tuberculous pleural effusion." International Journal of Research in Medical Sciences 11, no. 9 (2023): 3195–200. http://dx.doi.org/10.18203/2320-6012.ijrms20232767.

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Background: Tuberculous pleural effusion (TPE) is the most common etiology of exudative pleural effusion in high tuberculosis burden countries like Bangladesh. The usefulness of pleural fluid cholesterol for the diagnosis of TPE is not evaluated yet. This study aimed to assess the usefulness of pleural fluid cholesterol for the diagnosis of TPE. Methods: This cross-sectional study was conducted at the department of respiratory medicine at Bangabandhu Sheikh Mujib medical university. A total of thirty-five TPE was included in this study. Pleural fluid aspiration followed by cytological (total c

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Kavya, Dr Bollam, Dr Mohd Soheb Sadath Ansari, Dr Sara Ahmed, and Dr K. Ramesh Kumar. "A Study of Serum to Pleural Fluid Albumin Gradient in Differentiation of Exudative and Transudative Pleural Effusion in Comparison to Light’s Criteria." SAS Journal of Medicine 10, no. 05 (2024): 385–89. http://dx.doi.org/10.36347/sasjm.2024.v10i05.019.

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Pleural effusion is the accumulation of fluid between the parietal and visceral pleura called the pleural cavity. It can occur by itself or can be the result of surrounding parenchymal diseases like infection, malignancy or inflammatory conditions. Pleural effusion is one of the major causes of pulmonary mortality and morbidity. Both the visceral and the parietal pleura play an important role in fluid homeostasis in the pleural space. Pleural effusions develop when there is excess hydrostatic pressure in the pulmonary capillaries, when fluid removal is impaired by compromised lymphatic drainag

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Zoia, Andrea, Linda A. Slater, Jane Heller, David J. Connolly, and David B. Church. "A new approach to pleural effusion in cats: Markers for distinguishing transudates from exudates." Journal of Feline Medicine and Surgery 11, no. 10 (2009): 847–55. http://dx.doi.org/10.1016/j.jfms.2009.04.005.

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Classification of pleural effusion (PE) is central to diagnosis. Traditional veterinary classification has distinguished between transudates, modified transudates and exudates. In human medicine PEs are divided into only two categories: transudates and exudates. The aim of this study was to evaluate, in 20 cats presented with PE, paired samples of serum and pleural fluid for the following parameters: Light's criteria (pleural fluid lactate dehydrogenase concentration (LDHp), pleural fluid/serum LDH ratio, pleural fluid/serum total protein ratio (TPr)), pleural fluid total protein, pleural flui

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Yoon, Sumi, and Hye Ryoun Kim. "Analytical performance of the digital morphology analyzer Sysmex DI-60 for body fluid cell differential counts." PLOS ONE 18, no. 7 (2023): e0288551. http://dx.doi.org/10.1371/journal.pone.0288551.

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Background Sysmex DI-60 (Sysmex, Kobe, Japan) is a digital morphology (DM) analyzer widely used in clinical laboratories and supports body fluid (BF) applications. We evaluated analytical performance of DI-60 compared with XN-350 (Sysmex) and manual counting for BF cell differential counts. Methods A total of 213 BF samples were collected (47 cerebrospinal fluid [CSF], 80 pleural fluid, and 86 ascites samples). The analytical performance of DI-60 for BF cell differential counts was evaluated based on sensitivity, specificity, accuracy, and agreement. BF cell differential counts obtained by DI-

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Sadiq, Hina, Nasim Akhtar, Sana Virk, Kazim Abbas Virk, Abeer Zafar, and Lubna Meraj. "CD 4 count stratification and its accuracy in predicting the HIV-Tuberculosis co-infection." Infectious Diseases Journal of Pakistan 33, no. 2 (2024): 63–68. http://dx.doi.org/10.61529/idjp.v33i2.296.

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Background: Co-infection of HIV and TB is a significant public health concern. The relationship between increased HIV replication and low CD4+-TLC in HIV-positive patients with treatment interruptions is well documented. Moreover, TB preventive therapy is highly effective in reducing TB incidence and mortality among HIV-positive patients. The objective of this study was to stratify in terms of different ranges and see the association of CD4+ T-lymphocyte count with different presentations of TB in HIV-positive patients. Material and Methods: This observational cross-sectional study was conduct

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Hasan, Mahmudul, Md Rafiqul Islam, Abdul Matin, et al. "Laboratory Profiles of Pleural effusion Collected from Children: Experience at a Tertiary Care Hospital in Bangladesh." Journal of Shaheed Suhrawardy Medical College 5, no. 1 (2013): 26–27. http://dx.doi.org/10.3329/jssmc.v5i1.16201.

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Background: Pleural effusion occurs in many reasons. Laboratory tests are necessary to find out the causes. Objective: This study was an attempt to know the laboratory findings of pleural effusion. Methodology: This cross-sectional study of thirty (30) admitted cases with pleural effusion confirmed by chest radiography and aspiration of pleural fluid from one (1) year to twelve (12) years age of either sex were collected purposively. This study was carried out from July 2009 to February 2010 in the Department of Pediatrics at Rajshahi Medical College Hospital. All information were recorded in

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Probo, Monica, Valentina Valenti, Luigi Venco, et al. "Pleural lymphocyte-rich transudates in cats." Journal of Feline Medicine and Surgery 20, no. 8 (2017): 767–71. http://dx.doi.org/10.1177/1098612x17731045.

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Objectives Non-chylous lymphorrhagic pleural effusions are transudative effusions with a predominance of lymphocytes; however, they do not contain chylomicrons and therefore do not have the classical milky aspect of true chylous effusion. This type of effusion has been anecdotally associated with cardiac diseases in cats, but studies are lacking. The aim of this study was to investigate the association between this type of effusion and the primary disease. Methods In this study, feline non-chylous lymphorrhagic pleural effusions were retrospectively selected from the database of the authors’ i

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Souza, Mariana C., Carmen Penido, Maria F. S. Costa, and Maria Graças Henriques. "Mechanisms of T-Lymphocyte Accumulation during Experimental Pleural Infection Induced by Mycobacterium bovis BCG." Infection and Immunity 76, no. 12 (2008): 5686–93. http://dx.doi.org/10.1128/iai.00133-08.

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ABSTRACT Tuberculous pleurisy is a frequent extrapulmonary manifestation characterized by accumulation of fluid and inflammatory cells in the pleural space. Here, we investigated the mechanisms of T-lymphocyte accumulation in the pleural space by using a murine model of pleurisy induced by Mycobacterium bovis BCG. Intrathoracic (i.t.) injection of BCG (4.5 × 105 bacteria/cavity) induced accumulation of T lymphocytes in the pleural cavities of C57BL/6 mice. We observed the presence of CFU in pleural washes conducted 1, 2, 3, 7, and 15 days after pleurisy induction. Pretreatment with fucoidan in

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Irwadi, Didi, Sulina Y. Wibawa, and Hardjoeno Hardjoeno. "ANALISIS CAIRAN DARAH (TRANSUDAT) DAN SERUM CAMPURAN (EKSUDAT) DI PENDERITA DENGAN REMBESAN SELAPUT PARU (EFUSI PLEURA)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 15, no. 2 (2018): 57. http://dx.doi.org/10.24293/ijcpml.v15i2.947.

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Pleural effusion is a fluid excess into pleural cavity due to transudation or exudation processes. The fluid deposited in the cavity canthreat the patient’s life. The pleural effusion could be produced in a patient with tuberculosis, cancer, cardiac failure, renal failure orviral/bacterial infection. The study is aimed to analyze the patterns of substance in the pleural effusion fluids produced by differentdiseases. A cross sectional study was performed from June 2006 to June 2007 at Clinical Pathology Laboratory of Dr. WahidinSudirohusodo Hospital, Makassar. The fluids were tested for glucose

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Kozanlı, Fatoş, and Burcu Akkök. "Contribution of immature granulocyte level to diagnosis in pleural effusion." Turkish Journal of Thoracic and Cardiovascular Surgery 30, no. 2 (2022): 257–63. http://dx.doi.org/10.5606/tgkdc.dergisi.2022.21523.

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Background: In this study, we aimed to evaluate the diagnostic value of neutrophil and immature granulocyte levels in peripheral blood in cases with pleural effusion. Methods: Between May 2019 and May 2020, a total of 117 patients (43 males, 74 females; mean age: 63.1±18.1 years; range, 18 to 93 years) who had pleural effusion and analysis of pleural fluid were retrospectively analyzed. All patients were evaluated in terms of age, sex, presence of comorbid diseases, approach to the pleural fluid, biochemical values of peripheral blood and pleural fluid, hemogram series of peripheral blood, dia

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Salim, Ehab F., and Gaser A. Ali. "Diagnosis of pleural tuberculosis in the era of thoracoscopic surgery." Egyptian Journal of Chest Diseases and Tuberculosis 73, no. 4 (2024): 398–404. http://dx.doi.org/10.4103/ecdt.ecdt_20_24.

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Background Before thoracoscopic surgery, diagnosing tuberculous (TB) pleurisy was a medical challenge. Thoracoscopy is the most accurate but expensive method for TB pleurisy diagnosis. TB is common in low-income countries, where financial limitations prevent the use of thoracoscopy, motivating the search for a cheaper alternative. Patients and methods A prospective study was done from January 2019 to January 2023 to evaluate diagnostic methods for patients with exudative pleural effusions (PE) of unknown etiologies. The demographic, radiological, procedural, and histological data of exudative

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Auliya, Husnul, Roza Kurniati, and Fauzar. "Diagnosis and Management of Malignant Pleural Effusion: A Narrative Literature Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 12 (2022): 2449–56. http://dx.doi.org/10.37275/bsm.v6i12.624.

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Malignant pleural effusion (MPE) is defined as an effusion that occurs in association with malignancy, as evidenced by the finding of malignant cells on pleural fluid cytology or pleural biopsy. The pathophysiology of MPE is not yet clear, but several hypotheses have been developed to explain the mechanism of MPE. Accumulation of effusion in the pleural cavity occurs due to increased vascular permeability due to the inflammatory reaction caused by the infiltration of cancer cells in the parietal and/or visceral pleura. Other possible mechanisms are the direct invasion of the tumor adjacent to

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Agrahari, Mahendra, Kalyan Sapkota, Ranjita Singh, Prajawal Dhakal, and Joon Kumar Shrestha. "Clinical Profile of Patients with Pleural Effusion Admitted to Bharatpur Hospital." Journal of National Heart and Lung Society Nepal 2, no. 2 (2023): 72–76. http://dx.doi.org/10.3126/jnhls.v2i2.60752.

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ABSTRACT Background: Pleural effusion occurs when there is disequilibrium between the quantity of fluid entering and leaving the pleural space. The objective of the study was to investigate the association between pleural effusion and underlying medical conditions as heart failure, pneumonia, malignancies of clinical presentations and laboratory findings of all those patients admitted to Bharatpur Hospital during the period of last 1year. Methods: Retrospective data from September 2022 to September 2023 from all the cases diagnosed with pleural effusion will be taken. Altogether 12

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Carvalho, P., W. Kirk, J. Butler, and N. B. Charan. "Effects of tube thoracostomy on pleural fluid characteristics in sheep." Journal of Applied Physiology 74, no. 6 (1993): 2782–87. http://dx.doi.org/10.1152/jappl.1993.74.6.2782.

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We studied the pleural inflammatory response to tube thoracostomy by inserting an Argyle 32-Fr tube in the pleural space of 10 anesthetized sheep. An experimental pleural effusion was created by infusion of sterile normal saline (10 ml/kg) into the pleural space, and the animals were allowed to recover. Systemic blood and experimental pleural effusion (EPE) samples were obtained at time 0, 30 min, hourly for 6 h, and at 6-h intervals for a total of 48 h. EPE white cell count rose from 125 +/- 125 to 6,323 +/- 2,268/microliters (SE) at 6 h (P < 0.05) but showed marked variability at 42 and 4

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Grobbelaar, Madelein, Ronald van Toorn, and Regan Solomons. "Lumbar Cerebrospinal Fluid Evolution in Childhood Tuberculous Meningitis." Journal of Child Neurology 33, no. 11 (2018): 700–707. http://dx.doi.org/10.1177/0883073818785553.

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As early diagnosis of childhood tuberculous meningitis cannot rely on mycobacterial confirmation, clinical, cerebrospinal fluid and neuroimaging features are essential. We aimed to describe the evolution of serially analyzed lumbar cerebrospinal fluid parameters. We performed a retrospective observational study including children <13 years with suspected tuberculous meningitis at Tygerberg Hospital, Cape Town, South Africa. Cerebrospinal fluid parameters at admission and weeks 1, 2, and 3 were analyzed. Of 318 children with suspected tuberculous meningitis, 53 (17%) had “definite” tuberculo

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MUSHTAQ, AZAM, Salman AYYAZ, and SHAKEEL AHMED KHAN. "PLEURAL EFFUSION;." Professional Medical Journal 19, no. 06 (2012): 812–15. http://dx.doi.org/10.29309/tpmj/2012.19.06.2469.

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Objective: To determine the frequency of various diseases presenting with pleural effusion. Setting: Department of ChestMedicine, Nishtar Hospital, Multan. Period: March 2010 to September 2010. Material and methods: A total of 100 patients both sexes, morethan 12 years old, with clinically and radiologically confirmed pleural effusion underwent diagnostic thoracocentesis. Pleural fluid wasexamined grossly and for sugar, protein, LDH, total and differential white cell count and malignant cells. Pleural fluid culture and pleural biopsywas done in case of exudative effusion. Results: Tuberculosis

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Grigoruk, O. G., A. F. Lazarev, and L. M. Bazulina. "Diagnostic value of cytologic investigation of cell count differential of pleural fluid." PULMONOLOGIYA, no. 3 (June 28, 2007): 66–71. http://dx.doi.org/10.18093/0869-0189-2007-0-3-66-71.

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The cell count differential of pleural fluid sample is of great importance for estimation of the nature of pleural effusion. In the present article, we compared the efficiencies of routine cytology method with light microscopy, cytological examination with centrifuge Cytospin-4 and immunocytochemical methods. We have studied cytological samples from 1597 patients, with pleural effusion. Effusions associated with malignancies were reported in 22.7 % of patients including carcinomatosis (74.6 %), primary tumors of pleura (21.5 %), effusions associated with non epithelial malignancies (3.9 %). Be

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