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Journal articles on the topic 'PLEX'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Hammet, Fleur, Khalid Mahmood, Thomas R. Green, et al. "Hi-Plex2: a simple and robust approach to targeted sequencing-based genetic screening." BioTechniques 67, no. 3 (2019): 118–22. http://dx.doi.org/10.2144/btn-2019-0026.

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We have previously reported Hi-Plex, a multiplex PCR methodology for building targeted DNA sequencing libraries that offers a low-cost protocol compatible with high-throughput processing. Here, we detail an improved protocol, Hi-Plex2, that more effectively enables the robust construction of small-to-medium panel-size libraries while maintaining low cost, simplicity and accuracy benefits of the Hi-Plex platform. Hi-Plex2 was applied to three panels, comprising 291, 740 and 1193 amplicons, targeting genes associated with risk for breast and/or colon cancer. We show substantial reduction of off-

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2

Subramanyam, Meena, Tatiana Plavina, Bhupendra O. Khatri, Robert J. Fox, and Susan E. Goelz. "The effect of plasma exchange on serum anti-JC virus antibodies." Multiple Sclerosis Journal 19, no. 7 (2012): 912–19. http://dx.doi.org/10.1177/1352458512467502.

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Objective: Natalizumab, a highly effective treatment for multiple sclerosis (MS) and Crohn’s disease, is associated with progressive multifocal leukoencephalopathy (PML). Upon suspicion or diagnosis of PML, plasma exchange (PLEX) is performed to remove natalizumab from the circulation, allowing immune reconstitution of the central nervous system. Since PLEX may also remove other circulating antibodies, we examined the effects of PLEX on serum immunoglobulin (IgG) and anti–JC virus (JCV) antibody levels in MS patients with and without PML. Methods: Serum samples from 12 natalizumab-treated pati

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3

Malapati, Sindhu, Sunny R. K. Singh, Rohit Kumar, Jason Mouabbi, and Tarik Hadid. "Plasma Exchange in Thrombotic Microangiopathy: Is It Time Sensitive?" Blood 134, Supplement_1 (2019): 2353. http://dx.doi.org/10.1182/blood-2019-129375.

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Background: Thrombotic microangiopathy (TMA) has myriad causes with only subtle differences at presentation. Thrombotic thrombocytopenic purpura is one of the etiologies, and traditional teaching is that initiation of treatment with plasmapheresis (PLEX) is time sensitive allowing mitigation of the otherwise high morbidity and mortality of this condition. If TTP is suspected, PLEX is frequently initiated prior to availability of confirmatory lab tests. In contradiction to this, a recent publication by Liu et al (Blood 2017) found that early initiation of PLEX was not associated with improved i

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4

Valente, Guido, Giuseppina Nicotra, Marisa Arrondini, et al. "Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression." Analytical Cellular Pathology 31, no. 6 (2009): 423–36. http://dx.doi.org/10.1155/2009/151392.

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Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progression.Methods: The expression and distribution of Plex-B1 and Met were investigated by immunohistochemistry and immunofluorescence in 50 human neoplasias originating in the breast and ovary, and correlated

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5

Bonnan, Mickael, Rudy Valentino, Stéphane Debeugny, et al. "Short delay to initiate plasma exchange is the strongest predictor of outcome in severe attacks of NMO spectrum disorders." Journal of Neurology, Neurosurgery & Psychiatry 89, no. 4 (2017): 346–51. http://dx.doi.org/10.1136/jnnp-2017-316286.

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IntroductionSevere attacks of neuromyelitis optica spectrum disorder (NMO-SD) are improved by plasma exchange (PLEX) given as an adjunctive therapy. Initial studies failed to demonstrate a delay of PLEX treatment influenced clinical outcome; however PLEX was always used late. We examine the clinical consequences of delay in PLEX initiation on severe optic neuritis and spinal cord attacks in NMO-SD.MethodsAll of our patients who suffered attacks of NMO-SD, treated in our centre by PLEX, were retrospectively considered for inclusion. Primary outcome was defined as complete improvement. Secondary

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6

Bonnan, Mickael, and Philippe Cabre. "Plasma Exchange in Severe Attacks of Neuromyelitis Optica." Multiple Sclerosis International 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/787630.

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Background. Neuromyelitis optica (NMO) attacks are poorly controlled by steroids and evolve in stepwise neurological impairments. Assuming the strong humoral response underlying NMO attacks, plasma exchange (PLEX) is an appropriate technique in severe NMO attacks.Objective. Presenting an up-to-date review of the literature of PLEX in NMO.Methods. We summarize the rationale of PLEX in relation with the physiology of NMO, the main technical aspects, and the available studies.Results. PLEX in severe attacks from myelitis or optic neuritis are associated with a better outcome, depending on PLEX de

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7

Vennegoor, A., T. Rispens, BW Van Oosten, et al. "Application of serum natalizumab levels during plasma exchange in MS patients with progressive multifocal leukoencephalopathy." Multiple Sclerosis Journal 21, no. 4 (2014): 481–84. http://dx.doi.org/10.1177/1352458514541507.

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Progressive multifocal leukoencephalopathy (PML) is a severe complication of natalizumab treatment. Restoring immune function by plasmapheresis/immunoadsorption (PLEX/IA) is important for the outcome of PML. We report on four multiple sclerosis (MS) patients whom developed PML during natalizumab treatment, in whom we measured serum natalizumab concentrations before and during PLEX. Depending on the serum natalizumab concentration at the time of PML diagnosis, the number of PLEX treatments necessary to reach subtherapeutic serum natalizumab concentrations is variable. Measuring serum natalizuma

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8

Skorupka, Nic, Andrei Miclea, Katarzyna Aleksandra Jalowiec, et al. "Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis." Transfusion Medicine and Hemotherapy 46, no. 6 (2019): 417–22. http://dx.doi.org/10.1159/000504027.

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Introduction: In acute inflammatory optic neuritis (ON) as a typical onset of multiple sclerosis (MS), only few studies have investigated plasma exchange (PLEX) as a sequential treatment after insufficient response to high-dose intravenous glucocorticosteroids. Therefore, we aimed to investigate treatment outcome on visual acuity (VA) with PLEX in patients with steroid-refractory ON. Methods: In our retrospective monocentric study, medical records were screened for patients with acute ON as their first relapse with sequential MS diagnosis or with an established MS diagnosis from the Bern Unive

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9

Bomback, Andrew S., and Gerald B. Appel. "ANCA-associated GN—to PLEX or not to PLEX?" Nature Reviews Nephrology 9, no. 8 (2013): 436–38. http://dx.doi.org/10.1038/nrneph.2013.126.

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10

Komalasari, Ema, Winiati P. Rahayu, and Siti Nurjanah. "Evaluation of multiplex SYBR green real-time PCR assay for detection of pathogenic Escherichia coli." International Journal of Engineering & Technology 9, no. 2 (2020): 448. http://dx.doi.org/10.14419/ijet.v9i2.30389.

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Pathogenic Escherichia coli (E. coli) has been implicated in a wide range of disease causing infections. It is essential to generate a method for detecting and differentiating each pathotype of E. coli which is more quickly and efficiently by using less reagent. This study aimed to evaluate a SYBR Green multiplex real-time PCR method for detecting four types of pathogenic E. coli. Two of multiplex real-time PCR system, 6-plex and 3-plex, were set to detect six different virulence factors from ETEC, EPEC, EHEC, and EIEC and evaluate the melting curves and specificity compared to simplex method.

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11

Tyler, Kenneth L., and Timothy L. Vollmer. "To PLEX or not to PLEX in natalizumab-associated PML." Neurology 88, no. 12 (2017): 1108–9. http://dx.doi.org/10.1212/wnl.0000000000003747.

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12

Berberich, Amanda, Ahmed Ziada, and Robert A. Hegele. "To PLEX or not to PLEX: Managing Hypertriglyceridemia-associated Pancreatitis." Atherosclerosis Supplements 32 (June 2018): 148. http://dx.doi.org/10.1016/j.atherosclerosissup.2018.04.452.

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13

Abboud, Hesham, Alex Petrak, Maureen Mealy, Sarana Sasidharan, Laila Siddique, and Michael Levy. "Treatment of acute relapses in neuromyelitis optica: Steroids alone versus steroids plus plasma exchange." Multiple Sclerosis Journal 22, no. 2 (2015): 185–92. http://dx.doi.org/10.1177/1352458515581438.

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Background: Although adding plasma exchange (PLEX) to steroids in severe neuromyelitis optica (NMO) attacks is common practice in steroid-resistant cases, the benefit of this strategy has not been previously quantified. Objective: The objective of this paper is to compare the efficacy of high-dose intravenous methylprednisolone (IVMP) versus IVMP+PLEX in treatment of acute NMO relapses. Methods: We conducted a retrospective review of the last 83 NMO admissions to the Johns Hopkins Hospital treated with IVMP alone versus IVMP+PLEX (for steroid-resistant cases). Extended Disability Status Scale

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14

Joshi, Sweccha, Anna Segarra-Fas, Jeroen Peters, Han Zuilhof, Teris A. van Beek, and Michel W. F. Nielen. "Multiplex surface plasmon resonance biosensing and its transferability towards imaging nanoplasmonics for detection of mycotoxins in barley." Analyst 141, no. 4 (2016): 1307–18. http://dx.doi.org/10.1039/c5an02512e.

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15

Vlachopanos, Georgios, Argyrios Georgalis, and Harikleia Gakiopoulou. "Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis." Journal of Transplantation 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/639628.

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Background. Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival. A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX). We reviewed published studies to assess the role of PLEX on treatment of rFSGS in adults.Methods. Eligible manuscripts compared PLEX or variants with conventional care for inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and re

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16

Veltri, Lauren Westfall, Aaron Cumpston, Alexandra Shillingburg, et al. "Cost and Efficacy of Upfront Plerixafor Versus a “Just-in-Time” (JIT) Approach in Hematopoietic Progenitor Cell (HPC) Mobilization." Blood 124, no. 21 (2014): 1127. http://dx.doi.org/10.1182/blood.v124.21.1127.1127.

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Abstract HPC mobilization with plerixafor (Plex) plus G-CSF (G+P) results in superior CD34+ cell yield, when compared to mobilization with G-CSF alone in patients with myeloma and lymphoid malignancies. However, Plex-based approaches are associated with high mobilization costs. To circumvent higher costs, several institutions use a so-called JIT approach, where Plex is only administered to patients likely to fail mobilization with G-CSF alone. Whether such a JIT-Plex approach is cost effective has not been confirmed to date. We present here, a single institution comparative analysis of 137 pat

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17

Legault, Daniel J., and Mark R. Boelkins. "Successful Treatment of aHUS Recurrence and Arrest of Plasma Exchange Resistant TMA Post-Renal Transplantation with the Terminal Complement Inhibitor Eculizumab." Blood 114, no. 22 (2009): 2421. http://dx.doi.org/10.1182/blood.v114.22.2421.2421.

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Abstract Abstract 2421 Poster Board II-398 Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and acute renal failure (ARF). The prognosis for aHUS is poor as 25% of patients die during acute phases of the disease and 50% progress to end stage renal disease (ESRD). A high percentage of patients with aHUS experience recurrence and graft failure following renal transplantation. This report summarizes the successful use of a terminal complement inhibitor as a treatment for aHUS following

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18

Furlan, JC, D. Barth, C. Barnett, and V. Bril. "Cost-minimization analysis comparing intravenous immunoglobulin (IVIg) with plasma exchange (PLEX) in the management of patients with myasthenia gravis: different perspectives for different payers." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 42, S1 (2015): S18. http://dx.doi.org/10.1017/cjn.2015.100.

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Introduction: A cost-minimization analysis (CMA) was performed comparing IVIg and PLEX in the management of patients with exacerbation of myasthenia gravis (MG). Methods: This study combines Ontario-based health costing data with clinical data from a randomized clinical trial where patients with moderate/severe MG received either IVIg or PLEX. The CMA was undertaken under the perspective of a public health care insurer and under the perspective of a tertiary hospital payer. Results: The IVIg group (n=32) was comparable with the PLEX group (n=38) regarding demographics, disease characteristics

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19

Ramot, Yuval, Shlomo Nedvetzki, Sefi Rosenfeld, Noam Emanuel, and Abraham Nyska. "Toxicity and Safety Study of D-PLEX100 in a Sternal Surgical Defect in New Zealand White Rabbits." Toxicologic Pathology 47, no. 4 (2019): 504–14. http://dx.doi.org/10.1177/0192623319837887.

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Bacterial infections are a common complication after surgical procedures. Therefore, local delivery of antibiotics has been developed, including the use of biodegradable polymers. A newly developed product for prevention of surgical site infections is a polymer–lipid encapsulation matrix loaded with doxycycline, named D-PLEX100 (D-PLEX). We evaluated the toxicity and safety of D-PLEX using a sternal surgical defect model in rabbits. D-PLEX was tested with three different concentrations of doxycycline in comparison to sham-operated control after administration into the sternal surgical defect a

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20

McGinnis, Eric, Spencer D. Martin, and Tyler W. Smith. "Rapid Turnaround ADAMTS13 Testing Is Likely to Improve Diagnosis of Thrombotic Thrombocytopenic Purpura and Avoid Unnecessary Plasma Exchange." Blood 136, Supplement 1 (2020): 5–6. http://dx.doi.org/10.1182/blood-2020-140135.

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Introduction: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy (TMA) resulting from severe ADAMTS13 deficiency, which is generally treated with therapeutic plasma exchange (PLEX). Although ADAMTS13 activity is often assayed to differentiate TTP from TMAs not requiring PLEX, technical and logistical constraints often limit rapid turnaround of results, with PLEX initiated based on clinical suspicion of TTP while awaiting ADAMTS13 activity results. We estimated the potential reduction in plasma product use if rapid turnaround ADAMTS13 activity testing wer

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Griffiths, James C., Ray A. Matulka, and Ronan Power. "Acute and Subchronic Toxicity Studies on Sel-Plex®, a Standardized, Registered High-selenium Yeast." International Journal of Toxicology 25, no. 6 (2006): 465–76. http://dx.doi.org/10.1080/10915810600959626.

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Selenium has been recognized as an essential nutrient for human health; however, its bioavailability is primarily dependent upon the type of selenium, elemental versus organic. In geographic areas low in selenium, there is the potential for animals (including humans) to become selenium deficient and this potential deficiency can be remedied by consumption of exogenous selenium, including selenium-enriched yeast ( Saccharomyces cerevisiae) that contains high levels of organic selenium (e.g., selenized yeast). The present studies were conducted to investigate potential oral toxicity of a unique

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22

McClosky, Benjamin, Anthony Simms, and Illya V. Hicks. "Co-2-plex polynomials." Journal of Combinatorial Optimization 22, no. 4 (2010): 640–50. http://dx.doi.org/10.1007/s10878-010-9313-y.

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23

Zaidi, Gulrukh Z., Juliana A. Rosentsveyg, Katayoun F. Fomani, James P. Louie, and Seth J. Koenig. "Reversal of Severe Multiorgan Failure Associated With Sickle Cell Crisis Using Plasma Exchange: A Case Series." Journal of Intensive Care Medicine 35, no. 2 (2019): 140–48. http://dx.doi.org/10.1177/0885066619874041.

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Objective: Red blood cell exchange (RBCE) is the standard of care for patients with sickle cell disease (SCD) who present with severe vaso-occlusive crisis (VOC). However, subsets of these critically ill patients have progressive multiorgan failure (MOF) despite RBCE therapy. The purpose of this case series is to describe the use of plasma exchange (PLEX) for the treatment of SCD-related MOF that is refractory to RBCE. Methods: A retrospective case review of patients with severe MOF from sickle cell crisis unresponsive to RBCE who underwent PLEX in a 14-bed adult medical intensive care unit (I

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Ikeda, Kristin M., Donald H. Lee, J. Alexander Fraser, Seyed Mirsattari, and Sarah A. Morrow. "Plasma Exchange in a Patient with Tumefactive, Corticosteroid-Resistant Multiple Sclerosis." International Journal of MS Care 17, no. 5 (2015): 231–35. http://dx.doi.org/10.7224/1537-2073.2014-078.

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Tumefactive multiple sclerosis (MS) is an aggressive form of MS that can be difficult to treat with standard therapies. In severe MS relapses, plasma exchange (PLEX) has shown some benefit, but reports of its use in patients with tumefactive MS are limited. This article describes the successful use of PLEX in a patient with tumefactive MS. A 46-year-old right-handed woman with a recent diagnosis of MS presented with drowsiness, dysarthria, horizontal nystagmus, and quadriparesis. Her brain magnetic resonance images demonstrated multiple tumefactive demyelinating lesions in the medulla, bilater

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Gross, Ann Marie, Paulina Berdos, and Jack Ballantyne. "Y-STR Concordance Study Between Y-Plex?5, Y-Plex?6, Y-Plex?12, Powerplex�Y, Y-Filer?, MPI, and MPII." Journal of Forensic Sciences 51, no. 6 (2006): 1423–28. http://dx.doi.org/10.1111/j.1556-4029.2006.00289.x.

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Bakhsh, Shireen, Chia Wei Teoh, Elizabeth A. Harvey, and Damien G. Noone. "Single Pass Albumin Dialysis and Plasma Exchange for Copper Toxicity in Acute Wilson Disease." Case Reports in Nephrology and Dialysis 9, no. 2 (2019): 55–63. http://dx.doi.org/10.1159/000500104.

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Background: Wilson disease (WD) is a disorder of copper metabolism that results in accumulation of copper in tissues. In acute WD, patients present with fulminant hepatic failure, encephalopathy, and hemolytic anemia due to copper release from necrotic hepatocytes. Many will require life-saving liver transplantation. Extracorporeal liver support systems can provide a bridge to transplantation for critically ill patients. We report our experience with 2 patients for whom we used a combination of plasma exchange (PLEX) and single pass albumin dialysis (SPAD), or SPAD alone as a bridge to liver t

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Landi, Doriana, Nicola De Rossi, Sara Zagaglia, et al. "No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML." Neurology 88, no. 12 (2017): 1144–52. http://dx.doi.org/10.1212/wnl.0000000000003740.

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Objective:To examine retrospectively the effects of plasmapheresis (PLEX) on the survival and clinical outcomes of patients with multiple sclerosis (MS) and natalizumab (NTZ)–associated progressive multifocal leukoencephalopathy (PML).Methods:The medical literature was searched for the terms natalizumab and progressive multifocal leukoencephalopathy. A total of 193 international and 34 Italian NTZ-PML cases were included. Clinical outcome was determined by comparing the patients' clinical status at PML diagnosis with status after PML resolution. The effects on survival and clinical outcome of

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Griffiths, James C., Ray A. Matulka, and Ronan Power. "Genotoxicity Studies on Sel-Plex®, a Standardized, Registered High-Selenium Yeast." International Journal of Toxicology 25, no. 6 (2006): 477–85. http://dx.doi.org/10.1080/10915810600959667.

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Selenium, recognized as an essential nutrient for human health, is a component of proteins and enzymes required for various biological functions and is currently being used as a feed supplement for livestock in geographical areas that are naturally low in selenium. Selenium is structurally similar to sulfur, replacing the sulfur atom in stoichiometric amounts and thus functions through an association with proteins, termed selenoproteins. In geographic areas low in selenium, there is the potential for animals (including humans) to become selenium deficient and this potential deficiency can be r

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Putta, Aakash, Hafeez Shaka, Shristi Upadhyay Banskota, et al. "Therapeutic Plasma Exchange (PLEX) in Thrombotic Microangiopathy (TMA): Experiences of an Inner-City Hospital over a Decade." Blood 134, Supplement_1 (2019): 3691. http://dx.doi.org/10.1182/blood-2019-124265.

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Introduction: There are multiple mechanisms of occurrence of TMA. Some of the etiologies are associated with high morbidity and mortality, but there are very subtle differences in presentation. A high index of suspicion is recommended for thrombotic thrombocytopenic purpura (TTP) due to the time sensitive nature of treatment initiation and poor outcomes associated with delay in treatment. Due to this, treatment with PLEX is often initiated empirically before diagnostic test results are available. We aim to report the management and outcomes of TMA along with the predictive value of the PLASMIC

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Krolevets, A. A., N. I. Myachikova, O. V. Binkovskaya, S. G. Glotova, and E. M. Mamaeva. "Nanostructured selenium-containing amino acids: properties and applications in the production of functional foods." Tovaroved prodovolstvennykh tovarov (Commodity specialist of food products), no. 6 (May 20, 2021): 406–17. http://dx.doi.org/10.33920/igt-01-2106-01.

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The paper presents the properties of nanostructured Sel-Plex; self-organization and particle sizes are determined using the NTA method. It is shown that the average size of nanocapsules does not significantly depend on the nature of the shell and is 217–245 nm. It is proposed to use nanostructured Sel-Plex as a selenium-containing preparation in the production of marmalade and bakery products.

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McClosky, Benjamin, John D. Arellano, and Illya V. Hicks. "Co-2-plex vertex partitions." Journal of Combinatorial Optimization 30, no. 3 (2013): 729–46. http://dx.doi.org/10.1007/s10878-013-9664-2.

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Papeix, C., R. Depaz, A. Tourbah, B. Stankoff, and C. Lubetzki. "Dramatic worsening following plasma exchange in severe post-natalizumab withdrawal multiple sclerosis relapse." Multiple Sclerosis Journal 17, no. 12 (2011): 1520–22. http://dx.doi.org/10.1177/1352458511411064.

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We report the case of a young woman with multiple sclerosis who discontinued natalizumab twice and experienced a severe relapse following each natalizumab withdrawal. The first relapse was successfully treated by intravenous methylprednisolone (IVMP). In contrast the second relapse was unresponsive to IVMP. Subsequent treatment by plasma exchanges (PLEX) was followed by a dramatic neurological worsening. This case suggests that PLEX after natalizumab discontinuation may increase relapse severity.

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Taherian, Mehran, Maryam Aghighi, and Melissa Petras. "Opsoclonus Myoclonus Ataxia Syndrome With Anti–Glutamic Acid Decarboxylase Antibody Positive: Response to Plasma Exchange." American Journal of Clinical Pathology 152, Supplement_1 (2019): S153. http://dx.doi.org/10.1093/ajcp/aqz131.005.

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Abstract Objectives Opsoclonus myoclonus syndrome (OMS) is a very rare neurological disorder of probably autoimmune origin. Glutamic acid decarboxylase antibody (GAD-Ab) is one of many antibodies that have been associated with OMS. Common treatments include intravenous immunoglobulin (IVIG) and corticosteroids. To our knowledge, this is the fourth case of GAD-Ab-positive OMS reported and the first one responsive to plasma exchange (PLEX). Clinical Presentation The patient is a 77-year-old male who presented with new-onset tremors and gait disorder. He had been diagnosed with OMS and positive G

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Bilgin, E., E. Duran, E. Erkantarci Levent, et al. "POS0255 IMPACT OF PLASMA EXCHANGE (PLEX) IN SEVERE ANCA-ASSOCIATED VASCULITIS (AAV): A REAL-LIFE DATA FROM A PROSPECTIVE COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 350.1–350. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3169.

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Background:PEXIVAS was the largest clinical trial conducted on severe AAV patients and failed to demonstrate the contribution of PLEX on the prognosis of severe AAV. This data needs to be tested with real life experiences.Objectives:The aim of this study was to explore the effects of PLEX on the prognosis of severe AAV in a real-life cohort.Methods:Hacettepe University Vasculitis Research Center (HUVAC) prospective database was established in October 2014 by registering past and newly diagnosed patients. Baseline disease characteristics, treatments and survival status were recorded. For this s

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Sellmann, Dieter, and Michael Waeber. "Übergangsmetallkomplexe mit Schwefelliganden, XVIII. Synthese und Reaktionen von [Ru(L)(PPh3)dttd]-Komplexen mit kleinen Stickstoffverbindungen L = NH3, N2H4, N2H3CH3, N2H3C6H5 sowie NO+ (dttd2- = 2,3;8,9-Dibenzo-1,4,7,10-tetrathiadecan (–2))/ Transition Metal Complexes with Sulfur Ligands, XVIII. Synthesis and Reactions of [Ru(L)(PPh3)dttd] Complexes with Small Nitrogen Compounds L = NH3, N2H4, N2H3CH3, N2H3C6H5 and NO+ (dttd2- = 2,3;8,9-Dibenzo-1,4,7,10-tetrathiadecane (–2))." Zeitschrift für Naturforschung B 41, no. 7 (1986): 877–84. http://dx.doi.org/10.1515/znb-1986-0714.

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Abstract Reaktionen von [Ru(L)(PPh3)dttd]-Komplexen mit kleinen Stickstoffverbindungen L = NH3, N2H4, N2H3CH3, N2H3C6H5 sowie NO+ (dttd2-= 2,3;8,9-Dibenzo-l,4,7,10-tetrathiadecan (—2)) Transition Metal Complexes with Sulfur Ligands, XVIII* Synthesis and Reactions of [R u(L)(PPh3)dttd] Complexes with Small Nitrogen Com pounds L = N H 3, N2H 4, N2H 3C H 3, N2H 3C6H 5 and N O + (dttd2-= 2,3;8,9-D ibenzo-l,4,7,10-tetrathiadecane (—2)) D ieter Sellmann+ Ruthenium Sulfur C om plexes, N itrogen Ligands The com plex fragment [Ru(PPh3)dttd], (dttd2-= 2,3;8,9-dibenzo-l,4,7,10-tetrath iad ecane (— 2)), c

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Lv, Pin, Hongmei Zhu, Hongfang Wang, and George Wang. "Development of a 2-Plex Luminex-Based Competitive Immunoassay to Quantify Neutralizing Antibodies Induced by Virus-Like Particles for Human Papillomavirus 16 and 18." Journal of Biomedicine and Biotechnology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/272806.

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Human papillomavirus (HPV) L1 virus-like particles (VLPs) were proven an effective vaccine candidate to prevent against HPV-16 and -18 infections. In order to evaluate the potency of our produced HPV-16 and -18 L1 VLPs-based vaccine candidates, also to quantify neutralizing antibodies induced by them, a 2-plex Luminex-based competitive immunoassay was developed. Unlike the published paper, the no-biotin conjugated neutralizing mAbs spiked normal human serum (NHS) was used for standard curve preparation, while phycoerythrin (PE) was not labeled directly to neutralizing mAbs for signaling. After

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Hassan, Hamza, Abdul Rafae, Nimra Iftikhar, et al. "Role of extra corporeal methods for light chain removal on renal recovery in multiple myeloma: A systematic review." Journal of Clinical Oncology 37, no. 15_suppl (2019): e19530-e19530. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e19530.

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e19530 Background: Renal impairment (RI) in Multiple Myeloma (MM) adversely affects the prognosis. Removing circulating free light chains via hemodialysis (HD) or plasma exchange (PLEX) along with chemotherapy can improve renal outcomes in MM. Methods: Per PRISMA guidelines a systematic search yielded 7311 articles since 2009 on 4 databases. After screening, 16 studies were included. Results: Main modalities were high cut off (HCO) HD, high flux (HF) HD, conventional HD and PLEX. N = 541 patients underwent HD/PLEX. 375/541 (69.3%) patients received HCO HD. In 2 RCTs, there was no significant d

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Pichler, Peter, Thomas Köcher, Johann Holzmann, et al. "Peptide Labeling with Isobaric Tags Yields Higher Identification Rates Using iTRAQ 4-Plex Compared to TMT 6-Plex and iTRAQ 8-Plex on LTQ Orbitrap." Analytical Chemistry 82, no. 15 (2010): 6549–58. http://dx.doi.org/10.1021/ac100890k.

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Goshua, George, Amit Gokhale, Jeanne E. Hendrickson, Christopher Tormey, and Alfred Ian Lee. "Cost Effectiveness of Rituximab As Adjunctive Therapy in Reducing Apheresis Procedures and Hospital Length of Stay in Relapsed Thrombotic Thrombocytopenic Purpura." Blood 132, Supplement 1 (2018): 3814. http://dx.doi.org/10.1182/blood-2018-99-113621.

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Abstract Introduction: Rituximab at standard dosing (375 mg/m2 weekly for 4 weeks) is effective in preventing thrombotic thrombocytopenic purpura (TTP) relapse and is recommended as a therapy of choice along with plasmapheresis (PLEX) in the UK expert-based guidelines on TTP (category IB), although it is not yet universally viewed as standard of care. There is also emerging data for low dose rituximab (100 mg weekly for 4 weeks) in the treatment of relapsing TTP with mixed data on efficacy as compared to standard dose rituximab. With this in mind, we conducted a retrospective chart review to e

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Nemati, Zabihollah, Hosain Ahmadian, Maghsoud Besharati, et al. "Assessment of Dietary Selenium and Vitamin E on Laying Performance and Quality Parameters of Fresh and Stored Eggs in Japanese Quails." Foods 9, no. 9 (2020): 1324. http://dx.doi.org/10.3390/foods9091324.

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The effect of dietary supplementation with VE and Se on the laying productive performance, immunity, and the quality parameters of fresh and stored eggs was assessed. For this study, five treatments, namely control (basal diet), control plus 30 mg of VE and 0.4 mg kg−1 sodium selenite (VE30SS), control plus 30 mg of VE and 0.4 mg kg−1 of Sel-Plex® (VE30SP), control plus 120 mg VE and 0.4 mg kg−1 Sodium selenite (VE120SS), and control plus 120 mg VE and 0.4 mg kg−1 Sel-Plex (VE120SP), were examined. There was no huge impact of VE and Se on feed consumption, FCR and egg yield rate. Quality param

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Chernykh, V. V., V. I. Konenkov, O. V. Ermakova та ін. "Сontent of cytokines and growth factors in the intraocular fluid of patients with primary open-angle glaucoma". Bulletin of Siberian Medicine 18, № 1 (2019): 257–65. http://dx.doi.org/10.20538/1682-0363-2019-1-257-265.

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Purpose. To study the content of cytokines and growth factors in the intraocular fluid of patients with developed stage of primary open-angle glaucoma (POAG).Materials and methods. 56 patients with a verified diagnosis developed stage of primary open-angle glaucomawere examined. The control group consisted of 30 patients with a diagnosis of uncomplicated cataract. A concentration of 17 cytokinesand 3 isoforms of the transforming growth factor (TGF) β was determined using a Bio-Plex Pro™ Human Cytokine 17-plex Assay and Bio-Plex Pro™ and TGFβ 3-plex Assay kit by flow-through fluorometry on a Bi

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Casal Moura, Marta, Maria V. Irazabal, Alfonso Eirin, et al. "Efficacy of Rituximab and Plasma Exchange in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis with Severe Kidney Disease." Journal of the American Society of Nephrology 31, no. 11 (2020): 2688–704. http://dx.doi.org/10.1681/asn.2019111197.

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BackgroundTreatment of patients with ANCA-associated vasculitis (AAV) and severe renal involvement is not established. We describe outcomes in response to rituximab (RTX) versus cyclophosphamide (CYC) and plasma exchange (PLEX).MethodsA retrospective cohort study of MPO- or PR3-ANCA–positive patients with AAV (MPA and GPA) and severe kidney disease (eGFR <30 ml/min per 1.73 m2). Remission, relapse, ESKD and death after remission-induction with CYC or RTX, with or without the use of PLEX, were compared.ResultsOf 467 patients with active renal involvement, 251 had severe kidney disease. Patie

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Britze, Anders, Johan Palmfeldt, Niels Gregersen, and Therese Ovesen. "44-plex cytokine profile of cholesteatoma." Acta Oto-Laryngologica 134, no. 1 (2013): 41–50. http://dx.doi.org/10.3109/00016489.2013.844360.

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Glowatzki-Mullis, M. L., J. Muntwyler, and C. Gaillard. "Cost-effective parentage verification with 17-plex PCR for goats and 19-plex PCR for sheep." Animal Genetics 38, no. 1 (2007): 86–88. http://dx.doi.org/10.1111/j.1365-2052.2006.01550.x.

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Pottiez, Gwenael, Jayme Wiederin, Howard S. Fox, and Pawel Ciborowski. "Comparison of 4-plex to 8-plex iTRAQ Quantitative Measurements of Proteins in Human Plasma Samples." Journal of Proteome Research 11, no. 7 (2012): 3774–81. http://dx.doi.org/10.1021/pr300414z.

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Zhao, Xiao, Qiguan Qiu, Chang Li, et al. "Genome-based development of 15 microsatellite markers in fluorescent multiplexes for parentage testing in captive tigers." PeerJ 8 (May 6, 2020): e8939. http://dx.doi.org/10.7717/peerj.8939.

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As one of the most endangered species, tiger (Panthera tigris) inbreeding has become an urgent issue to address. Using a microsatellite (short tandem repeat, STR) identification system, paternity testing may be helpful to avoid inbreeding in captive breeding programs. In this study, we developed a genome-based identification system named tiger pedigree identification multiplex system (TPI-plex). By analyzing the entire tiger genome, 139,967 STR loci were identified and 12.76% of these displayed three to six alleles among three re-sequenced individual tiger genomes. A total of 204 candidate STR

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Chiruvolu, Neha V., Jonathan Scott, and Sam S. Yeh. "An Imperfect Marker: SLE and TTP-Like MAHA Without Low ADAMTS13." Journal of Investigative Medicine High Impact Case Reports 9 (January 2021): 232470962110297. http://dx.doi.org/10.1177/23247096211029746.

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Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal condition that can be challenging for clinicians to identify in the setting of autoimmune diseases such as systemic lupus erythematosus (SLE). This difficulty is compounded when a patient presents with all of the clinical signs of a TTP-like microangiopathy, however, with near normal ADAMTS13. This case report describes a 44-year-old female with a history of SLE who was hospitalized with acute on chronic anemia, thrombocytopenia, and altered mental status. The patient’s ADAMTS13 was mildly low; hence, she was initially treated fo

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Barnett, Carolina, Vera Bril, Moira Kapral, Abhaya V. Kulkarni, and Aileen M. Davis. "Myasthenia Gravis Impairment Index." Neurology 89, no. 23 (2017): 2357–64. http://dx.doi.org/10.1212/wnl.0000000000004676.

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Objective:To study responsiveness and meaningful change of the Myasthenia Gravis Impairment Index (MGII) and its relative efficiency compared to other measures.Methods:We enrolled 95 patients receiving prednisone, IV immunoglobulin (IVIg), or plasma exchange (PLEX) and 54 controls. Patients were assessed with the MGII and other measures—including the Quantitative Myasthenia Gravis Score, Myasthenia Gravis Composite, and Myasthenia Gravis Activities of Daily Living—at baseline and 3–4 weeks after treatment. Statistical markers of responsiveness included between-groups and within-group differenc

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Abraham, Alon, Leif E. Lovblom, and Vera Bril. "Baseline Decrement in Patients with Mild Myasthenia Gravis Predicts Immunomodulation Treatment." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, no. 6 (2019): 762–66. http://dx.doi.org/10.1017/cjn.2019.246.

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ABSTRACT:To explore whether higher degrees of electrophysiological abnormalities are associated with a more frequent exposure to a more aggressive treatment regimen, we performed a retrospective chart review of patients attending the neuromuscular clinic from June 2012 to December 2015 and included 87 patients. We compared treatment regimens during the follow-up period between patients with high and low jitter and decrement. Myasthenia gravis patients with high jitter or decrement at baseline were more frequently treated with intravenous immunoglobulins (IVIG) and/or plasma exchange (PLEX) dur

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Chen, Wenwen, Jiaying Zheng, Chang Wu, et al. "Breast Cancer Subtype Classification Using 4-Plex Droplet Digital PCR." Clinical Chemistry 65, no. 8 (2019): 1051–59. http://dx.doi.org/10.1373/clinchem.2019.302315.

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Abstract BACKGROUND Infiltrating ductal carcinoma (IDCA) is the most common form of invasive breast cancer. Immunohistochemistry (IHC) is widely used to analyze estrogen receptor 1 (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) that can help classify the tumor to guide the medical treatment. IHC examinations require experienced pathologists to provide interpretations that are subjective, thereby lowering the reproducibility of IHC-based diagnosis. In this study, we developed a 4-plex droplet digital PCR (ddPCR) for the simultaneous and quantitative analys

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