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Dissertations / Theses on the topic 'PLM for biomedical imaging'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Liu, Xiaojing. "Optical Coherence Photoacoustic Microscopy (OC-PAM) for Multimodal Imaging." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/3189.

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Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are suitable for being combined to achieve multimodal imaging. In this dissertation, an optical coh

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2

Pham, Cong Cuong. "Multi-utilisation de données complexes et hétérogènes : application au domaine du PLM pour l’imagerie biomédicale." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2365/document.

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L’émergence des technologies de l’information et de la communication (TIC) au début des années 1990, notamment internet, a permis de produire facilement des données et de les diffuser au reste du monde. L’essor des bases de données, le développement des outils applicatifs et la réduction des coûts de stockage ont conduit à l’augmentation quasi exponentielle des quantités de données au sein de l’entreprise. Plus les données sont volumineuses, plus la quantité d’interrelations entre données augmente. Le grand nombre de corrélations (visibles ou cachées) entre données rend les données plus entrel

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3

Huo, Donglai. "Quantitative Image Quality Evaluation of Fast Magnetic Resonance Imaging." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1155913518.

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4

Miao, Jun. "Optimization of Fast MR Imaging Technologies using the Case-PDM to Quantitatively Assess Image Quality." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1346966179.

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5

Luo, Yuan. "Novel Biomedical Imaging Systems." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193907.

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The overall purpose of the dissertation is to design and develop novel optical imaging systems that require minimal or no mechanical scanning to reduce the acquisition time for extracting image data from biological tissue samples. Two imaging modalities have been focused upon: a parallel optical coherence tomography (POCT) system and a volume holographic imaging system (VHIS). Optical coherence tomography (OCT) is a coherent imaging technique, which shows great promise in biomedical applications. A POCT system is a novel technology that replaces mechanically transverse scanning in the lateral

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6

Cole, Mary Janet. "Fluorescence lifetime imaging for biomedical applications." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393718.

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7

Meah, Christopher James. "Developing plenoptic technology for biomedical imaging." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7697/.

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Plenoptic imaging is an exciting research field since, by introducing a microlens array into the optical train of a traditional camera, directional information about incoming light rays is stored on the sensor. Whereas traditional cameras discard this information, plenoptic imaging takes advantage of this increase in angular resolution to provide a method of snapshot 3D capture. With a plenoptic dataset, the ability to extend depth of field and refocus digitally, post-acquisition, is of key benefit to bioluminescence tomography. Due to low light imaging conditions, large apertures are required

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8

Percival, Sarah Jane. "Functionalised silica nanoparticles for biomedical imaging." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44837.

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Magnetic resonance imaging is one of the most widely used diagnostic techniques in the clinic as it affords many of the attributes sought from a non-invasive imaging modality. The main limitation of MRI is its inherent insensitivity, and as a result only large-scale abnormalities can be detected from a scan. With an increasing demand for earlier cancer diagnosis there has been a move towards imaging the molecular biomarkers that are present from the beginning of the disease process. This thesis describes the development of highly fluorinated, silica nanoparticles to actively target cancer cell

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9

Huang, Jiwei. "Multispectral Imaging of Skin Oxygenation." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098.

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10

McPheeters, Matthew Thomas. "Imaging Corneal Nerve Activity." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1626615737894263.

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11

Steuwe, Christian. "Nonlinear photonics in biomedical imaging and plasmonics." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708016.

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12

Fairbairn, Natasha. "Imaging of plasmonic nanoparticles for biomedical applications." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/353976/.

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Plasmonic nanoparticles show potential for numerous different biomedical applications, including diagnostic applications such as targeted labelling and therapeutic applications such as drug delivery and therapeutic hyperthermia. In order to support the development of these applications, imaging techniques are required for imaging and characterising nanoparticles both in isolation and in the cellular environment. The work presented in this thesis relates to the use and development of two different optical techniques for imaging and measuring the localised surface plasmon resonance of plasmonic

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13

Amor, Rumelo. "Nonlinear and interference techniques for biomedical imaging." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24918.

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Optical microscopy has long been an established tool in the biomedical sciences, being the preferred choice in the study of single cells and tissue sections. The realisation of the confocal laser scanning microscope in the 1980s led to major advances in the way optical microscopy is implemented, paving the way for the use of interference techniques such as 4Pi microscopy to increase the optical resolution, and for nonlinear microscopy techniques such as two-photon microscopy, which allows deeper penetration and the imaging of live specimens as a consequence of reduced photo-bleaching, and cohe

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14

Sharkey-Toppen, Travis P. "Imaging Iron and Atherosclerosis by Magnetic Resonance Imaging." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429796182.

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15

Liu, Yehe. "System and Process Optimization for Biomedical Optical Imaging." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case162556700760192.

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16

Shen, Litao. "Diffusion tensor imaging application." Thesis, Purdue University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1602902.

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<p> Central nervous system (CNS) related conditions and diseases like mild traumatic brain injury (mTBI) and multiple sclerosis (MS) affect people’s life quality, yet there is no single test for the diagnosis of these diseases or conditions. Patients may need to wait for years until they are diagnosed correctly to get the correct treatment, which is often too late. Thus, there is a strong need to develop some techniques to aid the diagnosis of CNS-related conditions and diseases. The conventional MRI can reveal the structure of the brain but cannot detect the difference between the heal

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17

Levesque, Ives. "Magnetization transfer imaging of multiple sclerosis." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79030.

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Magnetization transfer (MT) imaging is a magnetic resonance imaging techniqu ewhich permits indirect observation of the macromolecular component of biological tissue. Semi-quantitative implementations such as magnetization transfer ratio (MTR) imaging are very useful in the study of neuro-degenerative diseases, despite the relatively limited information provided by such single measurement methods. Quantitative techniques provide estimated measures of model parameters that more accurately describe the MT process. This thesis presents the application of quantitative MT imaging in a cross-

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18

Cai, Hongmin. "Quality enhancement and segmentation for biomedical images." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39380130.

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19

Cai, Hongmin, and 蔡宏民. "Quality enhancement and segmentation for biomedical images." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39380130.

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20

Qin, Ruogu. "Intraoperative Imaging Platform." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1322617803.

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21

Tayyab, Muhammad. "Segmentation and Contrasting in Different Biomedical Imaging Applications." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00747430.

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Advancement in Image Acquisition Equipment and progress in Image Processing Methods have brought the mathematicians and computer scientists into areas which are of huge importance for physicians and biologists. Early diagnosis of diseases like blindness, cancer and digestive problems have been areas of interest in medicine. Development of Laser Photon Microscopy and other advanced equipment already provides a good idea of very interesting characteristics of the object being viewed. Still certain images are not suitable to extract sufficient information out of that image. Image Processing metho

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22

Pérez, Rosas Juan Miguel. "Imaging cytometry technology for environmental and biomedical applications." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/669608.

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Early detection of microorganisms in environmental and biomedical applications is critical for the effective response to potential pathogenic treats. Most traditional methods and instrumentation for the analysis of these samples are becoming obsolete due to the fact that they are time-consuming and have long response times. Modern solutions are limited to high-end centralized facilities and specialized trained personnel, given their high-cost and complexity. There is thus a clear need to develop and introduce low-cost, easy to use, high-performance devices capable of rapidly identifying and qu

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23

Amrania, Hemmel. "Ultrafast Mid-Infrared Spectroscopic Imaging with Biomedical Applications." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526408.

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24

Jin, Jiefu, and 金介夫. "Functional lanthanide-based nanoprobes for biomedical imaging applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47752579.

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Lanthanide-doped upconversion nanoparticles (UCNPs) are perceived as promising novel near-infrared (NIR) bioimaging agents characterised by high contrast and high penetration depth. However, the interactions between charged UCNPs and mammalian cells have not been thoroughly studied and the corresponding intracellular uptake pathways remain unclear. Herein, my research work involved the use of hydrothermal method and ligand exchange approach to prepare UCNP-PVP, UCNP-PEI, and UCNP-PAA. These polymer-coated UCNPs demonstrated good water dispersibility, the similar size distribution as

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25

Wang, Fangjing. "Biomedical Imaging of Stem Cells Using Reporter Genes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999.

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26

Yeo, Woon Gi. "Terahertz Spectroscopic Characterization and Imaging for Biomedical Applications." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430825935.

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27

Sandiford, Lydia Grace. "Development of novel nanomaterials for multimodal biomedical imaging." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/development-of-novel-nanomaterials-for-multimodal-biomedical-imaging(e0472af1-2c89-4b64-81b8-1bfbbfc12429).html.

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This thesis focuses on the development of novel nanomaterials for biomedical imaging using both iron oxide nanoparticles and cadmium based quantum dots, and two different coating methods. The first approach involved a coating ligand consisting of the stealth molecule polyethylene glycol, and a bisphosphonate enabling strong binding to the nanoparticle surface. This polymer conjugate was chosen in order to reduce undesirable reticuloendothelial system uptake, and hence increase blood circulation times allowing for efficient delivery of particles to specific in vivo vascular targets. The second

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28

Koh, Kevin Rongsheng. "Multimodal multispectral optical endoscopic imaging for biomedical applications." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6330.

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Optical imaging is an emerging field of clinical diagnostics that can address the growing medical need for early cancer detection and diagnosis. Various human cancers are amenable to better prognosis and patient survival if found and treated during early disease onset. Besides providing wide-field, macroscopic diagnostic information similar to existing clinical imaging techniques, optical imaging modalities have the added advantage of microscopic, high resolution cellular-level imaging from in vivo tissues in real time. This comprehensive imaging approach to cancer detection and the possibilit

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29

Schuessler, Thomas Florian. "Advances in pulmonary monitoring and thoracic imaging." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=34444.

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The high incidence of pulmonary disease in critically ill patients necessitates new and improved techniques for pulmonary monitoring and thoracic imaging. To investigate pulmonary monitoring techniques using pressure and flow signals, I developed a comprehensive computational model of subjects breathing spontaneously or with the support of an assist-ventilator. The model was used to quantitatively assess measurement techniques for dynamic intrinsic positive end-expiratory pressure (PEEP$ rm sb{i})$ and inspiratory work of breathing. The results demonstrate that some means of correction for bot

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30

Taylor, Carmen Celeste. "Imaging methodology for assessment of chronic disease." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324621.

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Thesis (Ph.D.)--University of California, San Francisco with the University of California, Berkeley, 2008.<br>Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5584. Adviser: Sharmila Majumdar.

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31

Hu, Simon. "Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: Pulse sequence development for compressed sensing rapid imaging and preclinical liver studies." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390048.

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Thesis (Ph.D.)--University of California, San Francisco with the University of California, Berkeley, 2009.<br>Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: . Adviser: Daniel B. Vigneron.

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32

Gao, Ying Gao. "Development of Quantitative Fast Imaging with Steady-State Free Precession (FISP) Techniques for High Field Preclinical Magnetic Resonance Imaging." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1475150834919997.

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33

Stefanovic, Bojana. "Functional magnetic resonance imaging of cerebral blood volume." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85650.

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This dissertation describes a novel method for quantifying venous cerebral blood volume (CBVv) changes accompanying normal functional activation and employs quantitative functional magnetic resonance imaging (fMRI) methods to study the hemodynamic and metabolic changes accompanying neuronal inhibition. An in vivo occipital lobe relaxometry study was performed first to investigate the dependence of the spin-spin relaxation time constant of tissue, T2tissue , on the refocusing interval over the range of interest and thus test the basis of the proposed CBVv method. The small decrease of th

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34

Ifediba, Marytheresa Akuigwe. "Small Interfering RNA Imaging Probes for Neurological Applications." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10675.

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Small interfering RNAs (siRNAs) have emerged as a potent new class of therapeutics that regulate gene expression through sequence-specific inhibition of mRNA translation. Clinical trials of siRNAs have highlighted the need for robust delivery and detection techniques that would enable the application of these therapeutics to increasingly complex diseases and organ systems. Here we detail the generation and evaluation of siRNA-based optical and magnetic resonance imaging (MRI) contrast agents for the treatment of neurological diseases, including ischemic stroke and glioblastoma multiforme brain

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35

Penmatsa, Madhuri Krishna. "Infrared Spectral Imaging Analysis Of Cartilage Repair Tissue." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/124100.

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Bioengineering<br>M.S.<br>Articular cartilage is a homogenous tissue that provides frictionless movement between joints while withstanding repetitive physical stress. Once degenerated as a result of osteoarthritis or an injury, it has very limited capacity for self-repair. Recent research has focused on developing many new technologies for cartilage repair. The successful application of these strategies is limited in part to lack of techniques to evaluate tissue response to interventions. Assessment of the structural and molecular changes in the primary cartilage components, proteoglycan (PG)

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36

Somoza, Eduardo A. Jr. "UTILIZATION OF FLUORESCENCE MOLECULAR IMAGING TO OPTIMIZE RADIONUCLIDE IMAGING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1338904705.

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37

Oswald, Annahita. "Coping with new Challenges in Clustering and Biomedical Imaging." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-134971.

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38

Henriksson, Tommy. "CONTRIBUTION TO QUANTITATIVE MICROWAVE IMAGING TECHNIQUES FOR BIOMEDICAL APPLICATIONS." Doctoral thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-5882.

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This dissertation presents a contribution to quantitative microwave imaging for breast tumor detection. The study made in the frame of a joint supervision Ph.D. thesis between University Paris-SUD 11 (France) and Mälardalen University (Sweden), has been conducted through two experimental microwave imaging setups, the existing 2.45 GHz planar camera (France) and the multi-frequency flexible robotic system, (Sweden), under development. In this context a 2D scalar flexible numerical tool based on a Newton-Kantorovich (NK) scheme, has been developed. Quantitative microwave imaging is a three dimen

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39

Olarte, Omar E. "Development of novel imaging tools for selected biomedical applications." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/144559.

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In the quest for better and faster images of cellular and subcellular structures, biology-oriented optical microscopes have advanced significantly in the last few decades. Novel microscopy techniques such as non-linear microscopy (NLM), including two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) microscopy, and light-sheet fluorescence microscopy (LSFM) are emerging as alternatives that overcome some the intrinsic limitations of standard microscopy systems. In this thesis I aimed to advance such techniques even more, and combine them with other photonic technologies t

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40

Kano, Angelique Lynn. "Ultrathin Single and Multi-Channel Fiberscopes for Biomedical Imaging." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/193617.

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Ultrathin fiberscopes typically have an imaging channel and an illumination channeland are available in diameters ranging from 0.5 mm to 2.5 mm. The minimum diam-eter can be reduced by combining the illumination and imaging paths into a singlefiberoptic channel. Constructing a single channel fiberscope requires a technique ofilluminating the tissue, while minimizing the Fresnel reflections and scatter withinthe common illumination and detection channel.A single channel fiberscope should image diffusely reflected light from tissue illu-minated with light filtered for the visible wavelength rang

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41

Liang, Chen. "Design of miniature microscope objective optics for biomedical imaging." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280105.

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The topic of this dissertation is on the design and construction of miniature microscope objective optics. The design of miniature microscope objective is both similar and different from conventional microscope objective. The design and construction of two miniature microscope objectives are presented in this dissertation. The first one is a high numerical aperture (NA), water-immersion objective and it is a part of a fiber confocal reflectance microscope (FCRM). The second one is a moderate NA dry objective and it is a part of a miniature microscope array (MMA). The capability, complexity and

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42

Butzer, Jochen Sieghard. "MARS-CT: Biomedical Spectral X-ray Imaging with Medipix." Thesis, University of Canterbury. Physics and Astronomy, 2009. http://hdl.handle.net/10092/3863.

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Computed Tomography is one of the most important image modalities in medical imaging nowadays. Recent developments have led to a new acquisition technique called 'dual-energy', where images are taken with different x-ray spectra. This enables for the first time spectral information in the CT dataset. Our approach was to use an energy resolving detector (Medipix) and investigate its potential in the medical imaging domain. Images are taken in different energy bins. For acquisition of the data, a CT scanner called 'Medipix All Resolution System' (MARS) scanner was constructed. It was upgraded

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43

Petrović, Nikola. "Measurement System for Microwave Imaging Towards a Biomedical Application." Doctoral thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-24878.

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Microwave imaging techniques have shown excellent capabilities in various fields such as civil engineering, nondestructive testing, industrial applications, and have in recent decades experienced strong growth as a research topic in biomedical diagnostics. Many research groups throughout the world work on prototype systems for producing images of human tissues in different biomedical applications, particularly breast tumor detection. However, the research community faces many challenges and in order to be competitive to other imaging modalities one of the means is to put emphasis on experiment

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Sparks, Hugh. "Development and biomedical application of fluorescence lifetime imaging endoscopes." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/28962.

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A flexible wide-field fluorescence lifetime imaging (FLIM) endoscope is developed for clinical applications. For remote imaging, a coherent fibre optic bundle was used which required techniques and protocols to be developed to minimise artefacts associated with dispersion and recover accurate lifetime estimates. Potentially gain switched pulsed laser diodes are better suited for the clinic than light sources used conventionally for FLIM endoscopy because they are more compact and lower in cost. By imaging ex vivo human tissue samples, it was demonstrated that gain-switched pulsed laser diodes

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45

Monfort, Tual Remy. "Non linear photonics : developments & applications in biomedical imaging." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/422862/.

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Nonlinear polarization is explored in a biological and a technological contexts. Experimental set-ups are developed and built for interrogating nonlinear polarization in biological environment. Most notably, a Coherent Anti-Stokes Raman Scattering (CARS) and Second Harmonic Generation (SHG) microscopes are implemented in the Institute for Life Sciences (IfLS) at Southampton University. CARS and SHG are nonlinear effects based on different contrasts but both are label-free−and as a consequence truly in vivo; without perturbation of the biological mechanisms in opposition to fluorescence techniq

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46

Ge, Haobo. "New functionalised carbon based nanomaterials for biomedical imaging applications." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681050.

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47

Luthman, Anna Siri Naemi. "Spectrally resolved detector arrays for multiplexed biomedical fluorescence imaging." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274904.

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The ability to resolve multiple fluorescent emissions from different biological targets in video rate applications, such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter-based imaging systems. Hyper and multispectral imaging facilitate the detection of both spatial and spectral information in a single data acquisition, however, instrumentation for spatiospectral data acquisition is typically complex, bulky and expensive. This thesis seeks to overcome these limitations by using recently commercialised compact and robust hyper/multispectral cameras bas

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48

Dorcéna, Cassandre Jenny. "Nanoparticles for Biomedical Imaging and Biomolecular Transport and Manipulation." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408915572.

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49

Ozturk, Isik Esin. "Implementation of parallel imaging techniques for lipid unaliasing and faster acquisition for improving spatial characterization of magnetic resonance spectroscopic imaging of gliomas." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3251939.

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50

Tardif, Christine. "Quantitative magnetic resonance imaging of cortical multiple sclerosis pathology." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96663.

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Immunohistochemistry (IHC) and advanced magnetic resonance imaging (MRI) studies over the last decade have corroborated that grey matter (GM) structures are extensively involved in multiple sclerosis (MS) pathology, revolutionizing the long time perception of MS as a white matter disease. Yet cortical GM lesions remain notoriously difficult to detect in vivo using MRI. The main objective of this thesis was to create a quantitative MRI acquisition and analysis framework for the study of cortical MS pathology in vivo. To achieve this, two complementary approaches were used: brain morphometry and

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