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Journal articles on the topic 'PLM'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ngoc My, Tran Thi. "ISOLATING THE MONOKARYON COLLECTION OF Pleurotus spp." Vietnam Journal of Science and Technology 55, no. 1A (2018): 73. http://dx.doi.org/10.15625/2525-2518/55/1a/12384.

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Pleurotus spp. is one of the most important cultivated mushrooms in the world by their nutrition and medicinal property. In Vietnam, although many Pleurotus species are popularly cultivated, but most of them are imported. These strains are easily degenerated when they are cultivated in large scale, because they are difficult to adapt to the environment of Vietnam. This research aims to construct the monokaryon collection of Pleurotus spp. with details of taxonomy, genetic diversity, cultivating traits, monokaryotic mating types focused on Pleurotus strains with the high yield, genetic stable a

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Yu, Xi, Haiqing Zhang, Abdelaziz Bouras, Yacine Ouzrout, and Aicha Sekhari. "Multi-Criteria Decision Making for PLM Maturity Analysis based on an Integrated Fuzzy AHP and VIKOR Methodology." Journal of Advanced Manufacturing Systems 17, no. 02 (2018): 155–79. http://dx.doi.org/10.1142/s0219686718500105.

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A wide range of product lifecycle management (PLM) maturity models are proposed to assess the relative position of companies on their road to complete PLM implementation. However, it is a tough job for the company to dynamically evaluate the gradual process of PLM maturity by using existing values and accurately make decisions of improving PLM maturity by selecting the optimum alternative. A fuzzy PLM components maturity model (PCMA) is presented to build the internal logical relationship between maturity levels and existing values that can automatically predict the unknown PLM maturity levels

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Conlon, Jo. "From PLM 1.0 to PLM 2.0: the evolving role of product lifecycle management (PLM) in the textile and apparel industries." Journal of Fashion Marketing and Management: An International Journal 24, no. 4 (2020): 533–53. http://dx.doi.org/10.1108/jfmm-12-2017-0143.

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PurposeProduct lifecycle management (PLM) is an enterprise-wide strategy gaining prominence across manufacturing. The fashion industry is a late adopter of PLM, yet within global fashion and textile organisations PLM is now becoming a mainstream approach to optimize core processes. This literature review analyses the latest academic research to establish a broad basis of understanding of PLM in the sector and identify potential future research directions.Design/methodology/approachA systematic literature review was conducted to investigate the current state and main perspectives of research on

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Sidorycheva, Elizaveta E., Vladimir A. Sidorychev, Ivan P. Efimov, and German V. Dmitrienko. "METHODS OF ECAD AND PDM/PLM SYSTEM INTEGRATION FOR THE AVIATION INSTRUMENT-MAKING ENTERPRISES." Автоматизация процессов управления 2, no. 68 (2022): 129–36. http://dx.doi.org/10.35752/1991-2927-2022-2-68-129-136.

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Throughout the life cycle of a product, a large amount of information is accumulated, the management of which is an extremely important and complex task. This task is solved by means of project data management systems PDM / PLM-systems (Product Data Management / Product Lifecycle Management). These systems provide an access to data on the product by various attributes and navigation based on its hierarchical structure. They also maintain information links between the product components and their describing documentation. The article discusses the challenges of modern enterprises of the aviatio

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Haller, Herbert, and Evi Held-Föhn. "654 Investigation of Germ Patency of a Polylactic Acid-based Membrane for the Treatment of Burns." Journal of Burn Care & Research 41, Supplement_1 (2020): S173. http://dx.doi.org/10.1093/jbcr/iraa024.273.

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Abstract Introduction Infections are a very serious complication during the treatment of burns. To avoid such infections, burn care dressings and skin substitutes should be impermeable to germs. Polylactic membranes (PLM) are based on polylactic acid (PLA) and as an elastic membrane it mimics the natural skin. They are indicated for superficial (2a°) and deep dermal/partial thickness (2b°) skin loss diseases like burns. While being permeable to oxygen and water vapor, they provide a physical barrier for microorganisms. The infection rate of the PLM in burns was about 2,9% on average and was pu

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Legout, A., and E. W. Biersack. "PLM." ACM SIGMETRICS Performance Evaluation Review 28, no. 1 (2000): 13–22. http://dx.doi.org/10.1145/345063.339340.

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С.И., Дегтярев, та Васильев Д.Н. "АНАЛИЗ РАЗВИТИЯ PLM-СИСТЕМ". ИННОВАЦИОННЫЕ НАУЧНЫЕ ИССЛЕДОВАНИЯ 4-3(6) (23 травня 2021): 28–34. https://doi.org/10.5281/zenodo.4782110.

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PLM-система представляет собой определенного рода деятельность в сфере бизнеса, связанную с эффективным управлением продуктов компании на протяжении всего их жизненного цикла, от этапа идеи и до момента его утилизации. PLM-система объединяет в себе многочисленные этапы производства, предоставляя абсолютно всю информацию о выпускаемом компанией изделии. В статье рассматриваются PLM-системы, формулируется определение, их основные цели и задачи, обозначаются области применения, описывается поэтапное развитие PLM-систем, начиная с 1970-х годов 20 века.

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Lee, Sang-Il, Kwang-Yeol Ryu, and Min-Seok Song. "Process Improvement for PDM/PLM Systems by Using Process Mining." Transactions of the Society of CAD/CAM Engineers 17, no. 4 (2012): 294–302. http://dx.doi.org/10.7315/cadcam.2012.294.

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Ghatge, Mohini S., and Kevin A. Reynolds. "The plmS2-Encoded Cytochrome P450 Monooxygenase Mediates Hydroxylation of Phoslactomycin B in Streptomyces sp. Strain HK803." Journal of Bacteriology 187, no. 23 (2005): 7970–76. http://dx.doi.org/10.1128/jb.187.23.7970-7976.2005.

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ABSTRACT Streptomyces sp. strain HK803 produces six analogues of phoslactomycin (Plm A through Plm F). With the exception of Plm B, these analogues contain a C-18 hydroxyl substituent esterified with a range of short-alkyl-chain carboxylic acids. Deletion of the plmS 2 open reading frame (ORF), showing high sequence similarity to bacterial cytochrome P450 monooxygenases (CYPs), from the Plm biosynthetic gene cluster has previously resulted in an NP1 mutant producing only Plm B (N. Palaniappan, B. S. Kim, Y. Sekiyama, H. Osada, and K. A. Reynolds, J. Biol. Chem. 278:35552-35557, 2003). Herein,

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Brookhart, Gary L., Michael D. Tomalski, Karim C. Lounes, Piet Meijer, Cornelis Kluft, and Klaus-Peter Radtke. "Recombinant Plasmin from Lemna: Purification, Characterization and In Vitro Comparison with Human Plasma-Derived Plasmin." Blood 108, no. 11 (2006): 4001. http://dx.doi.org/10.1182/blood.v108.11.4001.4001.

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Abstract Background: The fibrinolytic enzyme plasmin has gained renewed interest as a direct thrombolytic agent. Local delivery of plasmin via catheter into thrombi, combined with the efficient neutralization of plasmin that may escape from the clot by its inhibitors α2-antiplasmin (α2-AP) and α2-macroglobulin may provide safe and effective removal of pathologic blood clots. Objective: To overcome the potential for pathogen contamination associated with plasmin prepared from pooled human plasma, we have generated recombinant plasmin (r-PLM) from transgenic Lemna plants and compared its biologi

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Tulloch, Lindsay B., Jacqueline Howie, Krzysztof J. Wypijewski, et al. "The Inhibitory Effect of Phospholemman on the Sodium Pump Requires Its Palmitoylation." Journal of Biological Chemistry 286, no. 41 (2011): 36020–31. http://dx.doi.org/10.1074/jbc.m111.282145.

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Phospholemman (PLM), the principal sarcolemmal substrate for protein kinases A and C in the heart, regulates the cardiac sodium pump. We investigated post-translational modifications of PLM additional to phosphorylation in adult rat ventricular myocytes (ARVM). LC-MS/MS of tryptically digested PLM immunoprecipitated from ARVM identified cysteine 40 as palmitoylated in some peptides, but no information was obtained regarding the palmitoylation status of cysteine 42. PLM palmitoylation was confirmed by immunoprecipitating PLM from ARVM loaded with [3H]palmitic acid and immunoblotting following s

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Song, Jianliang, Xue-Qian Zhang, JuFang Wang, et al. "Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+-K+-ATPase." American Journal of Physiology-Heart and Circulatory Physiology 295, no. 4 (2008): H1615—H1625. http://dx.doi.org/10.1152/ajpheart.00287.2008.

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Phospholemman (PLM) regulates cardiac Na+/Ca2+ exchanger (NCX1) and Na+-K+-ATPase in cardiac myocytes. PLM, when phosphorylated at Ser68, disinhibits Na+-K+-ATPase but inhibits NCX1. PLM regulates cardiac contractility by modulating Na+-K+-ATPase and/or NCX1. In this study, we first demonstrated that adult mouse cardiac myocytes cultured for 48 h had normal surface membrane areas, t-tubules, and NCX1 and sarco(endo)plasmic reticulum Ca2+-ATPase levels, and retained near normal contractility, but α1-subunit of Na+-K+-ATPase was slightly decreased. Differences in contractility between myocytes i

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Bhattarai, Mohan, Gerardo Morell, and Ram S. Katiyar. "Rare Earth Doped Lead Zirconate Titanate Thin Films for Memory and Power Device Applications." ECS Meeting Abstracts MA2023-01, no. 30 (2023): 1817. http://dx.doi.org/10.1149/ma2023-01301817mtgabs.

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We fabricated thin films of (PbZr0.53Ti0.47)O3 (PZT) and (PbZr0.53Ti0.47)0.90(LaxSc1-x)0.10O3 where; x= 0, 0.2, 0.4, 0.6 and 0.8 denoted as [abbr. PL10x] PL0, PL2, PL4, PL6, and PL8 respectively on the LSMO buffer layer (bottom electrode) by using a PLD technique. The X-ray diffraction peaks show a single-phase perovskite structure of thin films with a preferred (100) orientation that coincides with the MgO and has tetragonal phase symmetry (P4mm). Pt electrodes were deposited at the top of thin films as top electrodes. We achieved higher dielectric permittivity (ε’) for PL0 and PL6 compared t

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DUPONT, DIDIER, and REMY GRAPPIN. "ELISA for differential quantitation of plasmin and plasminogen in cheese." Journal of Dairy Research 65, no. 4 (1998): 643–51. http://dx.doi.org/10.1017/s0022029998003173.

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Bovine plasmin (PLM) and its precursor plasminogen (PLG) are present in cheese, in which the proteinase is thought to play a significant role in proteolysis during ripening. PLM in cheese is usually assayed by enzymic techniques and concentrations are generally expressed as activities. In order to determine absolute concentrations of PLM and PLG in cheese, we have applied an ELISA previously developed for the differential determination of PLM and PLG in milk. The assay used two monoclonal antibodies, one specific for PLG and the other cross reacting with PLM and PLG. PLM concentration was obta

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Ogiwara, Kenichi, Keiji Nogami, Katsumi Nishiya, Nobuyuki Tsujii, and Midori Shima. "Procoagulant Activity of Antifibrinolytic Agents; A Novel Hemostatic Mechanism of Tranexamic Acid and Epsilon-Aminocaproic Acid." Blood 116, no. 21 (2010): 1151. http://dx.doi.org/10.1182/blood.v116.21.1151.1151.

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Abstract Abstract 1151 Tranexamic acid (TA) and epsilon-aminocaproic acid (EACA) of lysine analogs have been clinically used as antifibrinolytic agents. These hemostatic mechanism is that TA/EACA bind to lysine-binding sites (LBS) of plasmin (Plm)/plasminogen (Plg) and competitively prevents Plm/Plg from binding to fibrin(ogen), resulting in inhibition of Plm-induced fibrin(ogen) degradation. TA/EACA cause a conformational change of (Glu-)Plg by LBS binding, however, resulting in paradoxical promotion of Plg activation by Plg activators (PA). It has been known in vitro that TA/EACA promote Plm

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Möllhoff, Nicholas, and Denis Ehrl. "53 Use of Polylactic-acid-membrane in Split-thickness Skin Graft Donor Sites: A Prospective, Comparative, Randomized Study." Journal of Burn Care & Research 43, Supplement_1 (2022): S36—S37. http://dx.doi.org/10.1093/jbcr/irac012.056.

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Abstract Introduction Polyurethane film (PU) dressings are commonly applied for coverage of split-thickness skin graft (SSG) donor sites, while previous studies have suggested reduced morbidity using a polylactic acid membrane (PLM). To further investigate the optimal treatment approach, the presented study compared outcome of donor sites in patients receiving either PLM or PU. Methods This randomized clinical trial allocated patients requiring SSG to receive either PLM or PU at the donor-site. Primary endpoint was difference in donor site scar appearance between groups 3 months postoperativel

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Wognum, Nel, and Amy Trappey. "PLM challenges." Advanced Engineering Informatics 22, no. 4 (2008): 419–20. http://dx.doi.org/10.1016/j.aei.2008.07.007.

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Han, Fei, Julie Bossuyt, Jody L. Martin, Sanda Despa, and Donald M. Bers. "Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase." American Journal of Physiology-Cell Physiology 299, no. 6 (2010): C1363—C1369. http://dx.doi.org/10.1152/ajpcell.00027.2010.

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Phospholemman (PLM) is a major target for phosphorylation mediated by both PKA (at Ser68) and PKC (at both Ser63 and Ser68) in the heart. In intact cardiac myocytes, PLM associates with and inhibits Na+-K+-ATPase (NKA), mainly by reducing its affinity for internal Na+. The inhibition is relieved upon PLM phosphorylation by PKA or PKC. The aim here was to distinguish the role of the Ser63 and Ser68 PLM phosphorylation sites in mediating kinase-induced modulation of NKA function. We expressed wild-type (WT) PLM and S63A, S68A, and AA (Ser63 and Ser68 to alanine double mutant) PLM mutants in HeLa

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Peng, Wei Ping, Yan Ting Huang, Zhao Liu, Jing Li, and Rong Gao. "Applied-Information Technology with a Method of PLM Software in Component Library Development and Management Based on the Cloud Platform." Advanced Materials Research 1046 (October 2014): 485–91. http://dx.doi.org/10.4028/www.scientific.net/amr.1046.485.

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Aiming at the PLM component library system, this paper studied the characteristic and requirement of the development of the PLM component. The main goal of this research include: deploying PLM component library using open source project OpenStack and KVM; studying the component communication method under heterogeneous environments on the basis of distributing framework model Remote Method Invocation (RMI); designing PLM soft component’s facet and interface; putting forward the steps of developing the distributed PLM component based on EJB technology (include Session Bean, Entity Bean, Message

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Reis, Justin, Lianqin Zhang, Steve Cala, et al. "Expression of phospholemman and its association with Na+-K+-ATPase in skeletal muscle: effects of aging and exercise training." Journal of Applied Physiology 99, no. 4 (2005): 1508–15. http://dx.doi.org/10.1152/japplphysiol.00375.2005.

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Phospholemman (PLM) is a recently identified accessory protein of the Na+-K+-ATPase (NKA), with a high level of expression in skeletal muscle. The objectives of this study are to characterize the PLM in skeletal muscle and to test the hypothesis that, as an accessory protein of NKA, expression of PLM and its association with the α-subunits of NKA is regulated during aging and with exercise training. PLM was characterized in skeletal muscle of 6- and 16-mo-old sedentary middle-aged rats (Ms), and the effects of aging and exercise training were studied in Ms, 29-mo-old sedentary senescent, and 2

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Jia, Xiao Liang, Jun Hao Geng, and Li Jiang Huang. "Research on PLM-Oriented Collaboration Digital Process Planning Technology." Advanced Materials Research 156-157 (October 2010): 694–99. http://dx.doi.org/10.4028/www.scientific.net/amr.156-157.694.

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In order to solve problems of long product development cycle, low collaborative work efficiency in complex product manufacturing firm, the approach of PLM-oriented collaboration digital process planning is put forward. The state of arts on PLM-oriented collaboration process planning and business requirements in complex product manufacturing firms are analyzed. The advantages and needs of PLM-oriented collaboration process planning workflow in complex product manufacturing firm are described in detail. Technology architecture on PLM-oriented collaboration digital process planning is founded als

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Manoharan, Palanikumar, Tatiana L. Radzyukevich, Hesamedin Hakim Javadi та ін. "Phospholemman is not required for the acute stimulation of Na+-K+-ATPase α2-activity during skeletal muscle fatigue". American Journal of Physiology-Cell Physiology 309, № 12 (2015): C813—C822. http://dx.doi.org/10.1152/ajpcell.00205.2015.

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The Na+-K+-ATPase α2-isoform in skeletal muscle is rapidly stimulated during muscle use and plays a critical role in fatigue resistance. The acute mechanisms that stimulate α2-activity are not completely known. This study examines whether phosphorylation of phospholemman (PLM/FXYD1), a regulatory subunit of Na+-K+-ATPase, plays a role in the acute stimulation of α2 in working muscles. Mice lacking PLM (PLM KO) have a normal content of the α2-subunit and show normal exercise capacity, in contrast to the greatly reduced exercise capacity of mice that lack α2 in the skeletal muscles. Nerve-evoked

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Bell, James R., Erika Kennington, William Fuller, et al. "Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 2 (2008): H613—H621. http://dx.doi.org/10.1152/ajpheart.01332.2007.

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Phospholemman (PLM, FXYD1), abundantly expressed in the heart, is the primary cardiac sarcolemmal substrate for PKA and PKC. Evidence supports the hypothesis that PLM is part of the cardiac Na-K pump complex and provides the link between kinase activity and pump modulation. PLM has also been proposed to modulate Na/Ca exchanger activity and may be involved in cell volume regulation. This study characterized the phenotype of the PLM knockout (KO) mouse heart to further our understanding of PLM function in the heart. PLM KO mice were bred on a congenic C57/BL6 background. In vivo conductance cat

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Wang, JuFang, Erhe Gao, Jianliang Song та ін. "Phospholemman and β-adrenergic stimulation in the heart". American Journal of Physiology-Heart and Circulatory Physiology 298, № 3 (2010): H807—H815. http://dx.doi.org/10.1152/ajpheart.00877.2009.

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Phosphorylation at serine 68 of phospholemman (PLM) in response to β-adrenergic stimulation results in simultaneous inhibition of cardiac Na+/Ca2+ exchanger NCX1 and relief of inhibition of Na+-K+-ATPase. The role of PLM in mediating β-adrenergic effects on in vivo cardiac function was investigated with congenic PLM-knockout (KO) mice. Echocardiography showed similar ejection fraction between wild-type (WT) and PLM-KO hearts. Cardiac catheterization demonstrated higher baseline contractility (+dP/d t) but similar relaxation (−dP/d t) in PLM-KO mice. In response to isoproterenol (Iso), maximal

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Al-Sagheer, Adham, Mohamed Abd El-Hack, Mahmoud Alagawany, et al. "Paulownia Leaves as A New Feed Resource: Chemical Composition and Effects on Growth, Carcasses, Digestibility, Blood Biochemistry, and Intestinal Bacterial Populations of Growing Rabbits." Animals 9, no. 3 (2019): 95. http://dx.doi.org/10.3390/ani9030095.

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This experiment was conducted to study the effects of paulownia leaf meal (PLM) as a nontraditional feed on the growth, carcasses, digestibility, blood chemistry, and intestinal microbiota of growing rabbits. Sixty rabbits (5-weeks old) were randomly allotted to three dietary treatments containing three amounts of PLM (0%, 15%, and 30%). The results showed that PLM has a higher content of ether extract, organic matter, methionine, tyrosine, histidine, manganese, and zinc than alfalfa hay. Body weight gain decreased when 30% PLM was provided. The best feed conversion ratio was recorded in the r

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Zhang, Xue-Qian, Anwer Qureshi, Jianliang Song, et al. "Phospholemman modulates Na+/Ca2+exchange in adult rat cardiac myocytes." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 1 (2003): H225—H233. http://dx.doi.org/10.1152/ajpheart.00698.2002.

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Previous studies have shown that overexpression of phospholemman (PLM) affected contractile function and Ca2+ homeostasis in adult rat myocytes. We tested the hypothesis that PLM modulated Na+/Ca2+exchanger (NCX1) activity. PLM was overexpressed in adult rat myocytes by adenovirus-mediated gene transfer. After 72 h, the half-time of relaxation from caffeine-induced contracture, an estimate of forward NCX1 activity, was prolonged 1.8-fold ( P < 0.003) in myocytes overexpressing PLM compared with control myocytes overexpressing green fluorescent protein alone. Reverse NCX1 current (3 Na+ out:

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Morelli, Frank. "Digital Twin-Konzeption in der Automobilindustrie: Einsatzpotenziale der Blockchain-Technologie." Anwendungen und Konzepte der Wirtschaftsinformatik, no. 8 (December 20, 2018): 13. http://dx.doi.org/10.26034/lu.akwi.2018.3220.

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Digital Twins stehen stellvertretend für innovative IT-Konzepte, die gegenwärtig im Sinne der digitalen Transformation Branchen wie den Automobilbau revolutionieren. Ihr jeweiliges Ziel liegt in der vollständigen Abbildung aller relevanten Charakteristika eines Produkts und damit in einem verbesserten Produktdatenmanagement (PDM). Aus dynamischer Perspektive sind beim Management des Produktlebenszyklus (PLM) verschiedene Phasen zu differenzieren. Bereits bei der Elektrik/Elektronik (E/E)-Entwicklung im Fahrzeugbau muss eine Vielzahl an Informationen zwischen unterschiedlichen (internen und ext

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Wanichawan, Pimthanya, Kjetil Hodne, Tandekile Lubelwana Hafver, et al. "Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)." Biochemical Journal 473, no. 15 (2016): 2413–23. http://dx.doi.org/10.1042/bcj20160465.

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NCX1 (Na+/Ca2+ exchanger 1) is an important regulator of intracellular Ca2+ and a potential therapeutic target for brain ischaemia and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1 activity. However, although several studies have demonstrated that binding of phosphorylated PLM (pSer68-PLM) leads to NCX1 inhibition, other studies have failed to demonstrate a functional interaction of these proteins. In the present study, we aimed to analyse the biological function of the pSer68-PLM–

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Rossman, Matthew J., H. Jonathan Groot, Ryan S. Garten, Melissa A. H. Witman, and Russell S. Richardson. "Vascular function assessed by passive leg movement and flow-mediated dilation: initial evidence of construct validity." American Journal of Physiology-Heart and Circulatory Physiology 311, no. 5 (2016): H1277—H1286. http://dx.doi.org/10.1152/ajpheart.00421.2016.

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The vasodilatory response to passive leg movement (PLM) appears to provide a novel, noninvasive assessment of vascular function. However, PLM has yet to be compared with the established noninvasive assessment of vascular health, flow-mediated dilation (FMD). Therefore, as an initial evaluation of the construct validity of PLM and upright seated and supine PLM as well as brachial (BA) and superficial femoral (SFA) artery FMDs were performed in 10 young (22 ± 1) and 30 old (73 ± 2) subjects. During upright seated PLM, the peak change in leg blood flow (ΔLBF) and leg vascular conductance (ΔLVC) w

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Draghici, George. "Infrastructure for Integrated Collaborative Product Development in Distributed Environment." Applied Mechanics and Materials 760 (May 2015): 9–14. http://dx.doi.org/10.4028/www.scientific.net/amm.760.9.

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The tools used for collaborative product design is based on PLM solutions, integrating BOM, CAD, CAE, CAPP, CAM and PDM software. The PLM platforms are distributed in virtual project team of partners. Currently, the integrated collaborative and distributed product design and manufacture can be supported by the cloud technology, given advances in Cloud Computing. The objective of our research is to develop an infrastructure for integrated collaborative and distributed product design and manufacturing, including software applications, CNC machine tools, additive manufacturing machines etc., disp

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Ghatge, Mohini S., Nadaraj Palaniappan, Ma'moun M. Alhamadsheh, Jessica DiBari, and Kevin A. Reynolds. "Application of a Newly Identified and Characterized 18-O-Acyltransferase in Chemoenzymatic Synthesis of Selected Natural and Nonnatural Bioactive Derivatives of Phoslactomycins." Applied and Environmental Microbiology 75, no. 11 (2009): 3469–76. http://dx.doi.org/10.1128/aem.02590-08.

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ABSTRACT Phoslactomycins (PLMs) and related leustroducsins (LSNs) have been isolated from a variety of bacteria based on antifungal, anticancer, and other biological assays. Streptomyces sp. strain HK 803 produces five PLM analogs (PLM A and PLMs C to F) in which the C-18 hydroxyl substituent is esterified with a range of branched, short-alkyl-chain carboxylic acids. The proposed pathway intermediate, PLM G, in which the hydroxyl residue is not esterified has not been observed at any significant level in fermentation, and the only route to this potentially useful intermediate has been an enzym

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Zhang, Xue-Qian, J. Randall Moorman, Belinda A. Ahlers, et al. "Phospholemman overexpression inhibits Na+-K+-ATPase in adult rat cardiac myocytes: relevance to decreased Na+ pump activity in postinfarction myocytes." Journal of Applied Physiology 100, no. 1 (2006): 212–20. http://dx.doi.org/10.1152/japplphysiol.00757.2005.

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Messenger RNA levels of phospholemman (PLM), a member of the FXYD family of small single-span membrane proteins with putative ion-transport regulatory properties, were increased in postmyocardial infarction (MI) rat myocytes. We tested the hypothesis that the previously observed reduction in Na+-K+-ATPase activity in MI rat myocytes was due to PLM overexpression. In rat hearts harvested 3 and 7 days post-MI, PLM protein expression was increased by two- and fourfold, respectively. To simulate increased PLM expression post-MI, PLM was overexpressed in normal adult rat myocytes by adenovirus-medi

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Tucker, Amy L., Jianliang Song, Xue-Qian Zhang, et al. "Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: role of Na+/Ca2+ exchange." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 5 (2006): H2199—H2209. http://dx.doi.org/10.1152/ajpheart.01181.2005.

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Phospholemman (PLM) regulates contractility and Ca2+ homeostasis in cardiac myocytes. We characterized excitation-contraction coupling in myocytes isolated from PLM-deficient mice backbred to a pure congenic C57BL/6 background. Cell length, cell width, and whole cell capacitance were not different between wild-type and PLM-null myocytes. Compared with wild-type myocytes, Western blots indicated total absence of PLM but no changes in Na+/Ca2+ exchanger, sarcoplasmic reticulum (SR) Ca2+-ATPase, α1-subunit of Na+-K+-ATPase, and calsequestrin levels in PLM-null myocytes. At 5 mM extracellular Ca2+

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Zhang, Xue-Qian, JuFang Wang, Lois L. Carl, Jianliang Song, Belinda A. Ahlers, and Joseph Y. Cheung. "Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain." American Journal of Physiology-Cell Physiology 296, no. 4 (2009): C911—C921. http://dx.doi.org/10.1152/ajpcell.00196.2008.

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Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser68, PLM inhibits cardiac Na+/Ca2+ exchanger (NCX1). We previously demonstrated that the cytoplasmic tail of PLM interacts with the proximal intracellular loop (residues 218–358), but not the transmembrane (residues 1–217 and 765–938) or Ca2+-binding (residues 371–508) domains, of NCX1. In this study, we used intact Na+/Ca2+ exchanger with various deletions in the intracellular loop to map the interaction sites with PLM. We first demonstrated by Western blotting and confocal immunofluores

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Rangan, Ravi M., Steve M. Rohde, Russell Peak, Bipin Chadha, and Plamen Bliznakov. "Streamlining Product Lifecycle Processes: A Survey of Product Lifecycle Management Implementations, Directions, and Challenges." Journal of Computing and Information Science in Engineering 5, no. 3 (2005): 227–37. http://dx.doi.org/10.1115/1.2031270.

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The past three decades have seen phenomenal growth in investments in the area of product lifecycle management (PLM) as companies exploit opportunities in streamlining product lifecycle processes, and fully harnessing their data assets. These processes span all product lifecycle phases from requirements definition, systems design/ analysis, and simulation, detailed design, manufacturing planning, production planning, quality management, customer support, in-service management, and end-of-life recycling. Initiatives ranging from process re-engineering, enterprise-level change management, standar

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Mendel, Alan F. "Why Care About PLM?" Mechanical Engineering 133, no. 03 (2011): 42–43. http://dx.doi.org/10.1115/1.2011-mar-5.

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This article studies the role of product lifecycle management (PLM) in industrial engineering. The basic concepts of PLM—product data management, engineering change management, and product structure management—were also discussed. PLM provides data and management capabilities to reduce the non-value-added tasks required of engineers. It also increases engineering productivity, provides insight into engineering efforts, and improves product quality and customer satisfaction. Companies are receiving significant value and return from their PLM investments. Many companies begin implementing PLM by

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Gecevska, Valentina, Franc Cus, Polenakovic Radmil, and Paolo Chabert. "Process of innovation in product lifecycle management business strategy." Perspectives of Innovations, Economics and Business 9, no. 3 (2011): 53–56. https://doi.org/10.15208/pieb.2011.41.

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  This article proposes a scenario of Product Lifecycle Management (PLM), as a innovative business strategy based on the analysis of business drivers, industry requirements, limit of current solution, and recent state-of-the-art review in the domain related to PLM. Potential industrial impact of the developed PLM technology solutions is analyzed. It is hoped that the proposed PLM technology solutions will form the frontier basis for further research, development, and application of PLM systems to quickly adapt to the dynamic changing market for industry companies to pursue the most advanc

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Lansbery, Kristan L., Lauren C. Burcea, Margaretta L. Mendenhall, and Robert W. Mercer. "Cytoplasmic targeting signals mediate delivery of phospholemman to the plasma membrane." American Journal of Physiology-Cell Physiology 290, no. 5 (2006): C1275—C1286. http://dx.doi.org/10.1152/ajpcell.00110.2005.

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The FXYD protein family consists of several small, single-span membrane proteins that exhibit a high degree of homology. The best-known members of the family include the γ-subunit of the Na+-K+-ATPase and phospholemman (PLM), a phosphoprotein of cardiac sarcolemma. Other members of the family include corticosteroid hormone-induced factor (CHIF), mammary tumor protein of 8 kDa (Mat-8), and related to ion channels (RIC). The exact physiological roles of the FXYD proteins remain unknown. To better characterize the function of the members of the FXYD protein family, we expressed several members of

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Mr., Sagar Santu Shete Prof. Hredey Mishra. "INTRODUCTION OF PLM." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 6, no. 10 (2017): 284–87. https://doi.org/10.5281/zenodo.1012486.

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In industry, product lifecycle management (PLM) is the process of managing the entire lifecycle of a product from inception, through engineering design and manufacture, to service and disposal of manufactured products. PLM integrates people, data, processes and business systems and provides a product information backbone for companies and their extended enterprise. Product Lifecycle Management (PLM) helps you manage complex, cross-functional processes, coordinating the efforts of distributed teams to consistently and efficiently develop the best possible products. The PTC PLM software system m

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Gunpinar, Erkan, and Soonhung Han. "Interfacing heterogeneous PDM systems using the PLM Services." Advanced Engineering Informatics 22, no. 3 (2008): 307–16. http://dx.doi.org/10.1016/j.aei.2007.08.009.

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Liu, Boming, Xin Ma, Jianping Guo, et al. "Extending the wind profile beyond the surface layer by combining physical and machine learning approaches." Atmospheric Chemistry and Physics 24, no. 7 (2024): 4047–63. http://dx.doi.org/10.5194/acp-24-4047-2024.

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Abstract. Accurate estimation of the wind profile, especially in the lowest few hundred meters of the atmosphere, is of great significance for the weather, climate, and renewable energy sector. Nevertheless, the Monin–Obukhov similarity theory fails above the surface layer over a heterogeneous underlying surface, causing an unreliable wind profile to be obtained from conventional extrapolation methods. To solve this problem, we propose a novel method called the PLM-RF method that combines the power-law method (PLM) with the random forest (RF) algorithm to extend wind profiles beyond the surfac

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Nishiya, Katsumi, Keiji Nogami, Kiyotaka Okada, Osamu Matsuo, Kenichi Ogiwara, and Midori Shima. "Lysine-Binding Site-Dependent Interaction with Plasmin and Factor Va Responsible for Plasmin-Catalyzed Factor Va Inactivation." Blood 112, no. 11 (2008): 2016. http://dx.doi.org/10.1182/blood.v112.11.2016.2016.

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Abstract Plasmin (Plm), an active form of plasminogen (Plg), functions as a key enzyme in the fibrinolytic system. Furthermore, this enzyme directly inactivates various coagulation factors such as factor V (FV) and factor VIII (FVIII) by limited proteolysis, suggesting another role of Plm in the regulation of the coagulation system. We recently reported that Plm/Plg interacts with FVIII and its active form (FVIIIa), both dependently and independently of lysine-binding site (LBS) (Blood2007; 110, 522a). In this study, we attempted to localize a factor Va (FVa)-interactive region on Plm (and Plg

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Yang, Hua, and Chaogang Lou. "Plasmonic Lattice Modes with High Quality Factor in Inhomogeneous Environment." Journal of Physics: Conference Series 2597, no. 1 (2023): 012001. http://dx.doi.org/10.1088/1742-6596/2597/1/012001.

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Abstract Plasmonic lattice modes (PLM) with high quality factor is formed by periodic Au hemisphere arrays on the quartz substrates. The formation of PLM is attributed to the coupling between the localized surface plasmon resonance of Au hemispheres and the diffracted waves inside the substrates rather than the diffracted waves in the air. By changing the hemispheres’ size and the arrays’ period, the PLM wavelength is adjustable. It is also found that the refractive index of the substrates has no effect on the quality factor of PLM. As the refractive index increases, the position of the PLM wa

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ÜÇOK, Bilge, and Rüstem Barış YEŞİLAY. "Circular Economy From Product Lifecycle Management Perspective." Journal of Yaşar University 17, no. 67 (2022): 688–717. http://dx.doi.org/10.19168/jyasar.1006411.

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Ürün Yaşam Döngüsü Yönetimi (PLM), şirketlerin küresel pazarda rekabet edebilmeleri için bir ihtiyaç haline gelmiştir. PLM, en iyi kalitede üretim için en az zaman ve maliyetle işbirliği içinde çalışmanın bir gereğidir. Döngüsel ekonomi kullanımdan sonraki imha sürecinin yerine dönüşümü ve yeniden dönüşümü ifade eden bir anlayıştır. Döngüsel ekonomi kavramı hem sürdürülebilirlik hem de kârlılığını artırmak isteyen şirketler için giderek daha popüler hale gelmektedir. PLM sistemleri, döngüsel bir modele geçmek isteyen şirketler için önemli ölçüde yardım sağlayabilir. Bir PLM sistemi, bir ürünün

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Guo, Kai, Xianming Wang, Guofeng Gao, Congxin Huang, Keith S. Elmslie, and Blaise Z. Peterson. "Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels." American Journal of Physiology-Cell Physiology 299, no. 5 (2010): C1203—C1211. http://dx.doi.org/10.1152/ajpcell.00149.2010.

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We have found that phospholemman (PLM) associates with and modulates the gating of cardiac L-type calcium channels (Wang et al., Biophys J 98: 1149–1159, 2010). The short 17 amino acid extracellular NH2-terminal domain of PLM contains a highly conserved PFTYD sequence that defines it as a member of the FXYD family of ion transport regulators. Although we have learned a great deal about PLM-dependent changes in calcium channel gating, little is known regarding the molecular mechanisms underlying the observed changes. Therefore, we investigated the role of the PFTYD segment in the modulation of

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Singh, Shikha, and Subhas Chandra Misra. "Identification of barriers to PLM institutionalization in large manufacturing organizations." Business Process Management Journal 25, no. 6 (2019): 1335–56. http://dx.doi.org/10.1108/bpmj-12-2017-0367.

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Purpose The purpose of this paper is to study the barriers to institutionalize the product lifecycle management (PLM) in large manufacturing organizations. The paper explores the hurdles and identifies the causal barriers to support the organizations’ transformation into digitized firms. Design/methodology/approach The paper utilized the multi-criteria decision making technique, i.e., DEMATEL (DEcision MAking Trial and Evaluation Laboratory) method to find the causal barriers, and adopted maximum mean de-entropy (MMDE) algorithm to determine the threshold value based on the information entropy

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Araujo, Maria Auxiliadora de Paiva, Tatiana Mesquita e. Silva, Gustavo Antonio Moreira, Márcia Pradella-Hallinan, Sergio Tufik, and Acary Souza Bulle Oliveira. "Sleep disorders frequency in post-polio syndrome patients caused by periodic limb movements." Arquivos de Neuro-Psiquiatria 68, no. 1 (2010): 35–38. http://dx.doi.org/10.1590/s0004-282x2010000100008.

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Post-polio syndrome (PPS) in individuals with polio longer than 15 years is characterized by weakness and/or muscle fatigue, deficit of deglutition and breath and periodic limb movements (PLM) during sleep. We undertook a review of 99 patients with PPS, and assessed the frequency of PLM through polysomnographic recordings at our sleep disorders unit. The total number of PLM, total time of sleep (TTS), efficiency of sleep (EfS), awaking index (AI) and apnea-hypopnea index (AHI) were analyzed. Sixteen patients presented PLM in excess of 5 for the entire night. When comparing these with the group

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Elliott, M. L., E. Honeycutt, J. West, and P. Franklin. "First Report of Fusarium Wilt Caused by Fusarium oxysporum f. sp. canariensis on Canary Island Date Palm in Texas and South Carolina." Plant Disease 95, no. 3 (2011): 358. http://dx.doi.org/10.1094/pdis-11-10-0777.

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Canary Island date palm (Phoenix canariensis) is native to the Canary Islands and widely grown throughout the world as an ornamental. At a home site in Austin, TX in May 2008 and a commercial site near Charleston, SC in December 2009, declining Canary Island date palms were observed. Symptoms included individual leaves with chlorotic or necrotic leaflets on one side of the leaf blade (one-sided wilt or death) and a distinct reddish brown stripe along the petiole and rachis. Cross-sections through the petiole or rachis exhibited discoloration of internal tissue. Fusarium oxysporum was isolated

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Benziane, Boubacar, Ulrika Widegren, Sergej Pirkmajer, Jan Henriksson, Nigel K. Stepto, and Alexander V. Chibalin. "Effect of exercise and training on phospholemman phosphorylation in human skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301, no. 3 (2011): E456—E466. http://dx.doi.org/10.1152/ajpendo.00533.2010.

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Phospholemman (PLM, FXYD1) is a partner protein and regulator of the Na+-K+-ATPase (Na+-K+ pump). We explored the impact of acute and short-term training exercise on PLM physiology in human skeletal muscle. A group of moderately trained males ( n = 8) performed a 1-h acute bout of exercise by utilizing a one-legged cycling protocol. Muscle biopsies were taken from vastus lateralis at 0 and 63 min (non-exercised leg) and 30 and 60 min (exercised leg). In a group of sedentary males ( n = 9), we determined the effect of a 10-day intense aerobic cycle training on Na+-K+-ATPase subunit expression,

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Venturelli, Massimo, Gwenael Layec, Joel Trinity, Corey R. Hart, Ryan M. Broxterman, and Russell S. Richardson. "Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response." Journal of Applied Physiology 122, no. 1 (2017): 28–37. http://dx.doi.org/10.1152/japplphysiol.00806.2016.

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Passive leg movement (PLM)-induced hyperemia is a novel approach to assess vascular function, with a potential clinical role. However, in some instances, the varying chronotropic response induced by PLM has been proposed to be a potentially confounding factor. Therefore, we simplified and modified the PLM model to require just a single PLM (sPLM), an approach that may evoke a peripheral hemodynamic response, allowing a vascular function assessment, but at the same time minimizing central responses. To both characterize and assess the utility of sPLM, in 12 healthy subjects, we measured heart r

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