Relevant bibliographies by topics / PLSCR1[Phospholipide Scramblase]

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  2. Dissertations / Theses

Academic literature on the topic 'PLSCR1[Phospholipide Scramblase]'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "PLSCR1[Phospholipide Scramblase]"

1

Zhou, Quansheng, Ji Zhao, Therese Wiedmer, and Peter J. Sims. "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1." Blood 99, no. 11 (2002): 4030–38. http://dx.doi.org/10.1182/blood-2001-12-0271.

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Phospholipid scramblase 1 (PLSCR1) is an endofacial plasma membrane protein proposed to participate in transbilayer movement of phosphatidylserine and other phospholipids. In addition to its putative role in the reorganization of plasma membrane phospholipids, PLSCR1 is a substrate of intracellular kinases that imply its possible participation in diverse signaling pathways underlying proliferation, differentiation, or apoptosis. Because PLSCR1 is prominently expressed in a variety of blood cells, we evaluated PLSCR activity in platelets and erythrocytes, and cytokine-dependent growth of hemato
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Zhou, Quansheng, Ji Zhao, Fahad Al-Zoghaibi та ін. "Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α". Blood 95, № 8 (2000): 2593–99. http://dx.doi.org/10.1182/blood.v95.8.2593.

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Abstract Interferons (IFNs) mediate their diverse biologic activities through induction of the expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated genes has been well characterized, most of the molecular and cellular events underlying the constellation of biologic responses to the IFNs remain unresolved. This study showed that the newly identified PLSCR1 gene for phospholipid scramblase, previously implicated in remodeling of plasma membrane phospholipids, is regulated at the transcriptional level by IFN-. Analysis of 5′ flanking genomic sequence in repo
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3

Zhou, Quansheng, Ji Zhao, Fahad Al-Zoghaibi та ін. "Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α". Blood 95, № 8 (2000): 2593–99. http://dx.doi.org/10.1182/blood.v95.8.2593.008k32_2593_2599.

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Interferons (IFNs) mediate their diverse biologic activities through induction of the expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated genes has been well characterized, most of the molecular and cellular events underlying the constellation of biologic responses to the IFNs remain unresolved. This study showed that the newly identified PLSCR1 gene for phospholipid scramblase, previously implicated in remodeling of plasma membrane phospholipids, is regulated at the transcriptional level by IFN-. Analysis of 5′ flanking genomic sequence in reporter cons
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4

Benhamou, M. "Scrambling des phospholipides et Phospholipid Scramblase 1 (PLSCR1) dans les mastocytes activés." Revue Française d'Allergologie 57, no. 5 (2017): 389–95. http://dx.doi.org/10.1016/j.reval.2017.02.235.

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5

Li, Youjun, Kenneth Rogulski, Quansheng Zhou, Peter J. Sims, and Edward V. Prochownik. "The Negative c-Myc Target Onzin Affects Proliferation and Apoptosis via Its Obligate Interaction with Phospholipid Scramblase I." Molecular and Cellular Biology 26, no. 9 (2006): 3401–13. http://dx.doi.org/10.1128/mcb.26.9.3401-3413.2006.

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ABSTRACT Onzin, the product of a negatively c-Myc-regulated target gene, is highly expressed in myeloid cells. As a result of its interaction with and activation of Akt1 and Mdm2, onzin down-regulates p53. The apoptotic sensitivity of several cell lines is thus directly related to onzin levels. We have conducted a search for additional onzin-interacting proteins and identified phospholipid scramblase 1 (PLSCR1), an endofacial membrane protein, which is proposed to mediate the bidirectional movement of plasma membrane phospholipids during proliferation and apoptosis. PLSCR1 interacts with the s
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6

Dong, Beihua, Quansheng Zhou, Ji Zhao, et al. "Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon." Journal of Virology 78, no. 17 (2004): 8983–93. http://dx.doi.org/10.1128/jvi.78.17.8983-8993.2004.

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ABSTRACT Phospholipid scramblase 1 (PLSCR1) is an interferon (IFN)- and growth factor-inducible, calcium-binding protein that either inserts into the plasma membrane or binds DNA in the nucleus depending on its state of palmyitoylation. In certain hematopoietic cells, PLSCR1 is required for normal maturation and terminal differentiation from progenitor cells as regulated by select growth factors, where it promotes recruitment and activation of Src kinases. PLSCR1 is a substrate of Src (and Abl) kinases, and transcription of the PLSCR1 gene is regulated by the same growth factor receptor pathwa
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7

Wiedmer, Therese, and Peter Sims. "Unraveling the Mysteries of Phospholipid Scrambling." Thrombosis and Haemostasis 86, no. 07 (2001): 266–75. http://dx.doi.org/10.1055/s-0037-1616224.

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SummaryPlasma membrane phospholipid asymmetry is maintained by an aminophospholipid translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) from outer to inner membrane leaflet. Cell activation or injury leads to redistribution of all major lipid classes within the plasma membrane, resulting in surface exposure of PS and PE. Cell surface-exposed PS can serve as receptor sites for coagulation enzyme complexes, and contributes to cell clearance by the reticuloendothelial system. The mechanism(s) by which this PL ”scrambling” occurs is poorly understood. A protein ca
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8

Zhao, Ke-Wen, Xi Li, Qian Zhao та ін. "Protein kinase Cδ mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation". Blood 104, № 12 (2004): 3731–38. http://dx.doi.org/10.1182/blood-2004-04-1630.

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Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in leukemic cell differentiation. We show that all-trans retinoic acid (ATRA), an effective differentiation-inducing agent of acute promyelocytic leukemic (APL) cells, can elevate PLSCR1 expression in ATRA-sensitive APL cells NB4 and HL60, but not in maturation-resistant NB4-LR1 cel
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9

SUZUKI, ERIKO, OLGA AMENGUAL, TATSUYA ATSUMI, et al. "Increased Expression of Phospholipid Scramblase 1 in Monocytes from Patients with Systemic Lupus Erythematosus." Journal of Rheumatology 37, no. 8 (2010): 1639–45. http://dx.doi.org/10.3899/jrheum.091420.

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Objective.A high incidence of thromboembolic events has been reported in patients with systemic lupus erythematosus (SLE). Phosphatidylserine (PS) is normally sequestered in the inner leaflet of cell membranes. Externalization of PS during cell activation is mediated by phospholipid scramblase 1 (PLSCR1) and has a central role in promoting blood coagulation. We investigated the underlying pathogenic status of thrombophilia in SLE by analyzing PLSCR1 expression on monocytes from patients with SLE.Methods.Sixty patients with SLE were evaluated. Twenty-three patients had antiphospholipid syndrome
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10

Chen, Yan, Bao-An Chen, and Qing-long Guo. "Wogonoside Exerts Anti-Leukemia of AML Cells Via Restricting Phospholipid Scramblase 1 Gene Expression and Promoting Its Translocation Into Nuclear." Blood 118, no. 21 (2011): 4282. http://dx.doi.org/10.1182/blood.v118.21.4282.4282.

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Abstract Abstract 4282 Objective: To evaluate the antileukemic effect of wogonoside and reveal the underlying mechanism. Method: In this study trypan blue dye exclusion assay, MTT assay, and soft agar colony formation assay were used to analysis growth inhibition of wogonoside the on AML (acute human promyelocytic) cell lines. Propidium iodide (PI)-staining and cell cycle-regulatory proteins detecting by western blots were applied to exam whether wogonoside could induce cell cycle arrest. Then a series of experiment were used to assess the ability of wogonoside to overcome the AML associated d
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Dissertations / Theses on the topic "PLSCR1[Phospholipide Scramblase]"

1

Kassas-Guediri, Asma. "Caractérisation du rôle de la Phospholipide Scramblase 1 (PLSCR1) dans l'activation mastocytaire et les réactions allergiques IgE-dépendantes." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC135.

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Les mastocytes (MC) sont les acteurs principaux des réactions allergiques d'hypersensibilité de type I par la libération de médiateurs pro-inflammatoires suite à leur activation via le récepteur de haute affinité pour les immunoglobulines de classe E (RFcc1). Le laboratoire a identifié la Phospholipide Scramblase 1 (PLSCRI) comme un nouvel effecteur moléculaire de la signalisation du RFcsI. La PLSCR1 amplifie la dégranulation et la production de VEGF du MC par son implication dans la voie initiée par la tyrosine kinase Lyn. De plus, la PLSCR1 est associée à Lyn et Syk et est fortement phosphor
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2

Amir-Moazami, Omid. "La phospholipide scramblase 1 (PLSCR1) : un nouvel effecteur de la signalisation du récepteur de haute affinité aux immunoglobulines de type E." Paris 6, 2007. http://www.theses.fr/2007PA066278.

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Les mastocytes sont les sentinelles du système immunitaire , et jouent un rôle majeur dans les allergies ou réaction d’hyper-sensibilité de type I. Ces cellules expriment le RFceI constitué de 4 chaïnes : , b et 2 g comportant chacune un domaine ITAM. L’agrégation du RFceI par IgE+Ag induit la phosphorylation des domaines ITAM permettant l’initiation de 2 voies de signalisation dépendantes de Lyn et de Fyn. Ces voies sont régulées par des kinases et des phosphatases et mènent à la libération de médiateurs pro-inflammatoires et de cytokines. Dans ce contexte, il a été montré que la PLSCR1 est
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3

Bunjobpol, Wilawan. "Functional analysis of the interaction of HPV 16 E6 with phospholipid scramblase-1 (PLSCR1)." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511917.

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4

Chen, Chun Yu, and 陳俊宇. "Mechanism of phospholipid scramblase 1 (PLSCR1) involved in colorectal cancer tumorigenesis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/80217156696342615468.

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博士<br>長庚大學<br>生物醫學研究所<br>102<br>Phospholipid Scramblase 1 (PLSCR1) has been demonstrated overexpression in tissues of colorectal cancer. The purpose of this study is to examine the mechanism of PLSCR1 in CRC tumorigenesis. We compared the expression of PLSCR1, Src, Shc, Ras, Erk and cyclin D1 between colorectal carcinoma and adjacent normal mucosa by western blot. Totally, 22 pairs of tissues were observed that Src, Shc and cyclin D1 are significant up-regulated in colorectal carcinoma compare with normal tissue. PLSCR1 monoclonal antibody (PLSCR1 mAb) that binds to residues 1-30 of PLSCR1 rep
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