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Relevant bibliographies by topics / Pluripotent Stem Cells (PSCs)

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Academic literature on the topic 'Pluripotent Stem Cells (PSCs)'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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Journal articles on the topic "Pluripotent Stem Cells (PSCs)"

1

Samruan, Worawalan, Nathalie Beaujean, and Marielle Afanassieff. "Pluripotent Stem Cells for Transgenesis in the Rabbit: A Utopia?" Applied Sciences 10, no. 24 (2020): 8861. http://dx.doi.org/10.3390/app10248861.

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Pluripotent stem cells (PSCs) possess the following two main properties: self-renewal and pluripotency. Self-renewal is defined as the ability to proliferate in an undifferentiated state and pluripotency as the capacity to differentiate into cells of the three germ layers, i.e., ectoderm, mesoderm, and endoderm. PSCs are derived from early embryos as embryonic stem cells (ESCs) or are produced by reprogramming somatic cells into induced pluripotent stem cells (iPSCs). In mice, PSCs can be stabilized into two states of pluripotency, namely naive and primed. Naive and primed PSCs notably differ

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Leyendecker Junior, Alessander. "TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells". Stem Cells International 2018 (2 липня 2018): 1–13. http://dx.doi.org/10.1155/2018/7878201.

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Due to their potential for tissue engineering applications and ability to modulate the immune system and reduce inflammation, mesenchymal stem cells (MSCs) have been explored as a promising option for the treatment of chronic diseases and injuries. However, there are problems associated with the use of this type of cell that limit their applications. Several studies have been exploring the possibility to produce mesenchymal stem cells from pluripotent stem cells (PSCs). The aim of these studies is to generate MSCs with advantageous characteristics of both PSCs and MSCs. However, there are stil

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Fu, Xuemei, Shouhai Wu, Bo Li, Yang Xu, and Jingfeng Liu. "Functions of p53 in pluripotent stem cells." Protein & Cell 11, no. 1 (2019): 71–78. http://dx.doi.org/10.1007/s13238-019-00665-x.

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Abstract Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body, and thus hold great promise for regenerative medicine. To achieve their clinical potential, it is critical for PSCs to maintain genomic stability during the extended proliferation. The critical tumor suppressor p53 is required to maintain genomic stability of mammalian cells. In response to DNA damage or oncogenic stress, p53 plays multiple roles in maintaining genomic stability of somatic cells by inducing cell cycle arrest, apoptosis, and sen

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Abu-Dawud, R., N. Graffmann, S. Ferber, W. Wruck, and J. Adjaye. "Pluripotent stem cells: induction and self-renewal." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1750 (2018): 20170213. http://dx.doi.org/10.1098/rstb.2017.0213.

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Pluripotent stem cells (PSCs) lie at the heart of modern regenerative medicine due to their properties of unlimited self-renewal in vitro and their ability to differentiate into cell types representative of the three embryonic germ layers—mesoderm, ectoderm and endoderm. The derivation of induced PSCs bypasses ethical concerns associated with the use of human embryonic stem cells and also enables personalized cell-based therapies. To exploit their regenerative potential, it is essential to have a firm understanding of the molecular processes associated with their induction from somatic cells.

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Wang, Xuepeng, and Qiang Wu. "The Divergent Pluripotent States in Mouse and Human Cells." Genes 13, no. 8 (2022): 1459. http://dx.doi.org/10.3390/genes13081459.

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Pluripotent stem cells (PSCs), which can self-renew and give rise to all cell types in all three germ layers, have great potential in regenerative medicine. Recent studies have shown that PSCs can have three distinct but interrelated pluripotent states: naive, formative, and primed. The PSCs of each state are derived from different stages of the early developing embryo and can be maintained in culture by different molecular mechanisms. In this review, we summarize the current understanding on features of the three pluripotent states and review the underlying molecular mechanisms of maintaining

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Pei, Yangli, Liang Yue, Wei Zhang, Jinzhu Xiang, Zhu Ma, and Jianyong Han. "Murine pluripotent stem cells that escape differentiation inside teratomas maintain pluripotency." PeerJ 6 (January 4, 2018): e4177. http://dx.doi.org/10.7717/peerj.4177.

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Background Pluripotent stem cells (PSCs) offer immense potential as a source for regenerative therapies. The teratoma assay is widely used in the field of stem cells and regenerative medicine, but the cell composition of teratoma is still elusive. Methods We utilized PSCs expressing enhanced green fluorescent protein (EGFP) under the control of the Pou5f1 promoter to study the persistence of potential pluripotent cells during teratoma formation in vivo. OCT4-MES (mouse embryonic stem cells) were isolated from the blastocysts of 3.5-day OCT4-EGFP mice (transgenic mice express EGFP cDNA under th

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Nishimura, Ken, Aya Fukuda, and Koji Hisatake. "Mechanisms of the Metabolic Shift during Somatic Cell Reprogramming." International Journal of Molecular Sciences 20, no. 9 (2019): 2254. http://dx.doi.org/10.3390/ijms20092254.

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Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), hold a huge promise for regenerative medicine, drug development, and disease modeling. PSCs have unique metabolic features that are akin to those of cancer cells, in which glycolysis predominates to produce energy as well as building blocks for cellular components. Recent studies indicate that the unique metabolism in PSCs is not a mere consequence of their preference for a low oxygen environment, but is an active process for maintaining self-renewal and pluripotency, possibly in pr

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Ávila-González, Daniela, Mikel Ángel Gidi-Grenat, Guadalupe García-López, et al. "Pluripotent Stem Cells as a Model for Human Embryogenesis." Cells 12, no. 8 (2023): 1192. http://dx.doi.org/10.3390/cells12081192.

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Pluripotent stem cells (PSCs; embryonic stem cells and induced pluripotent stem cells) can recapitulate critical aspects of the early stages of embryonic development; therefore, they became a powerful tool for the in vitro study of molecular mechanisms that underlie blastocyst formation, implantation, the spectrum of pluripotency and the beginning of gastrulation, among other processes. Traditionally, PSCs were studied in 2D cultures or monolayers, without considering the spatial organization of a developing embryo. However, recent research demonstrated that PSCs can form 3D structures that si

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Ivanova, Julia S., and Olga G. Lyublinskaya. "Redox Homeostasis and Regulation in Pluripotent Stem Cells: Uniqueness or Versatility?" International Journal of Molecular Sciences 22, no. 20 (2021): 10946. http://dx.doi.org/10.3390/ijms222010946.

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Pluripotent stem cells (PSCs) hold great potential both in studies on developmental biology and clinical practice. Mitochondrial metabolism that encompasses pathways that generate ATP and produce ROS significantly differs between PSCs and somatic cells. Correspondingly, for quite a long time it was believed that the redox homeostasis in PSCs is also highly specific due to the hypoxic niche of their origin—within the pre-implantation blastocyst. However, recent research showed that redox parameters of cultivated PSCs have much in common with that of their differentiated progeny cells. Moreover,

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Rosa, Alessandro, and Monica Ballarino. "Long Noncoding RNA Regulation of Pluripotency." Stem Cells International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/1797692.

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Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chroma

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Dissertations / Theses on the topic "Pluripotent Stem Cells (PSCs)"

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Lee, Yee-ki Carol, and 李綺琪. "Pluripotent stem cells for cardiac regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46918462.

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Sarkar, Debarchana. "Retinal differentiation of pluripotent stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50712706.

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The retina is an internal photosensitive neural tunic which absorbs light and prevents it from reflecting back. The light receptors and neurons of the retina are initial processor of visual information. Various anomalies of the retina such as retinitis pigmentosa, cone-rod dystrophy to retinal degenerative diseases cause severe loss of vision since they affect photoreceptors directly or indirectly. Conventional therapies have never been fully successful in restoring vision in such diseases. However current research in stem cell therapies has shown remarkable potential. In this project, induce

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Sartori, Chiara. "Generation of ovine induced pluripotent stem cells." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6491.

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Embryonic stem cells (ESCs) are pluripotent cells derived from the early embryo and are able to differentiate into cells belonging to the three germ layers. They are a valuable tool in research and for clinical use, but their applications are limited by ethical and technical issues. In 2006 a breakthrough report described the generation of induced pluripotent stem cells (iPSCs). IPSCs are ESC-like cells generated from somatic cells by forcing the ectopic expression of specific transcription factors. This circumvents the ethical issues about the use of embryos in research and provides multiple

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Sun, Bowen. "Genomic imprinting in mouse pluripotent stem cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609478.

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Fynes, K. "Oxygen controlled processing of pluripotent stem cells." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1450000/.

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A major challenge facing the development of effective cell therapies is the efficient differentiation of pluripotent stem cells (PSCs) into pure populations. This is caused, in part, by the heterogeneous presence of functionally distinct subpopulations in undifferentiated PSCs. These can exhibit variable developmental potential, suggesting that there will be a heterogeneous response to differentiation cues, and a low yield of the target cell type. The importance of recapitulating the in vivo stem cell niche during stem cell process development is now widely acknowledged, and thus, manipulation

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Veiga, Bruno Rafael Assis da. "Induced pluripotent stem cells: tradução e terminologia." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10636.

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Mestrado em Tradução Especializada<br>Nos dias de hoje existe uma controvérsia enorme em torno do uso de células estaminais provenientes do cordão umbilical e das células estaminais de fetos. Esta é uma controvérsia com a qual os cientistas têm lidado todos os dias. Agora existe um tipo células em tudo semelhante às células estaminais, no entanto, estas não provêm de células estaminais de fetos ou do cordão umbilical, mas sim de células maduras – células da pele. De forma a conciliar a necessidade de realizar um projeto de tradução especializada com a vontade de divulgar um tema tão important

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Zhang, Yuelin, and 張月林. "Mesenchymal stem cells derived from pluripotent stem cells for cardiovascular repair and regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196438.

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Despite major advances in pharmacological and surgical treatments of cardiovascular diseases (CVDs), clinical outcomes of patients with severe CVDs remain very poor. Most of medication and interventions currently available are only playing roles of preventing further damage to myocardium, declining the risk of on-going cardiovascular events, lifting the cardiac pumping efficiency and lower early mortality rates, none of these treatments can regenerate or repair damaged cardiac tissue or restore heart function. As a result, several new strategies have been explored to overcome limitations of cu

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Kardel, Melanie Dawn. "Analysis of hematopoiesis from human pluripotent stem cells." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33333.

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Human embryonic stem (ES) or induced pluripotent stem (iPS) cells have the potential ability to generate all of the cell types in the body. If their differentiation into relevant cell types of interest can be effectively controlled, they are attractive for developmental studies, disease modelling, drug testing, and advancing regenerative medicine. The generation of hematopoietic cells from human ES/iPS cells has been reported, but is highly variable and often inefficient. My specific objective in this thesis was to more fully characterize the process whereby hematopoietic cells are generated f

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Adams, William James. "Human Vascular Endothelium from Induced Pluripotent Stem Cells." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10816.

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The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-der

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Henry, Marianne Patricia. "The genomic health of human pluripotent stem cells." Thesis, Brunel University, 2018. http://bura.brunel.ac.uk/handle/2438/17081.

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Human pluripotent stem cells are increasingly used for cell-based regenerative therapies worldwide, with the use of embryonic and induced pluripotent stem cells as potential treatments for a range of debilitating and chronic conditions. However, with the level of chromosomal aneuploidies the cells may generate in culture, their safety for therapeutic use could be in question. This study aimed to develop sensitive and high-throughput assays for the detection and quantification of human pluripotent stem cell aneuploidies, to assess any changes in their positioning in nuclei, as well as investiga

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Books on the topic "Pluripotent Stem Cells (PSCs)"

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Lakshmipathy, Uma, and Mohan C. Vemuri, eds. Pluripotent Stem Cells. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-348-0.

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W, Rosales Derek, and Mullen Quentin N, eds. Pluripotent stem cells. Nova Science Publishers, 2009.

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Lakshmipathy, Uma, Chad C. MacArthur, Mahalakshmi Sridharan, and Rene H. Quintanilla. Human Pluripotent Stem Cells. John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119394372.

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Schwartz, Philip H., and Robin L. Wesselschmidt, eds. Human Pluripotent Stem Cells. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-201-4.

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Yildirim, Sibel. Induced Pluripotent Stem Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-2206-8.

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Rugg-Gunn, Peter, ed. Human Naïve Pluripotent Stem Cells. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1908-7.

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Nagy, Andras, and Kursad Turksen, eds. Induced Pluripotent Stem (iPS) Cells. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2119-6.

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Turksen, Kursad, and Andras Nagy, eds. Induced Pluripotent Stem (iPS) Cells. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3055-5.

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Hescheler, Jürgen, and Erhard Hofer, eds. Adult and Pluripotent Stem Cells. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8657-7.

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Sullivan, Patrick J. Induced stem cells. Nova Science, 2011.

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Book chapters on the topic "Pluripotent Stem Cells (PSCs)"

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Yildirim, Sibel. "Pluripotent Cells." In SpringerBriefs in Stem Cells. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-2206-8_2.

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Sakamoto, Tatsunori, Koji Nishimura, Hiroe Ohnishi, and Takehiro Iki. "Pluripotent Stem Cells." In Regenerative Medicine for the Inner Ear. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54862-1_31.

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Azizi, Hossein, Akbar Hajizadeh Moghaddam, and Thomas Skutella. "Pluripotent Stem Cells." In Stem-Cell Nanoengineering. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118540640.ch2.

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Im, Gun-Il. "Pluripotent Stem Cells: Embryonic/Fetal Stem Cells and Induced Pluripotent Stem Cells." In Orthobiologics. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84744-9_30.

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Price, Jack. "Induced Pluripotent Stem Cells." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_7013.

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van Mil, Alain, Klaus Neef, Geerthe M. Balk, Jan Willem Buikema, Joost P. G. Sluijter, and Pieter A. F. M. Doevendans. "Induced Pluripotent Stem Cells." In Clinical Cardiogenetics. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45457-9_26.

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Takahashi, Kazutoshi, and Shinya Yamanaka. "Induced Pluripotent Stem Cells." In Regenerative Medicine. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9075-1_8.

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Fakoya, Adegbenro Omotuyi John, Adekunle Ebenezer Omole, Nihal Satyadev, and Khawaja Husnain Haider. "Induced Pluripotent Stem Cells." In Handbook of Stem Cell Therapy. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2655-6_40.

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Okita, Keisuke, Kazutoshi Takahashi, and Shinya Yamanaka. "Induced Pluripotent Stem Cells." In Regenerative Medicine. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5690-8_8.

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Zaehres, Holm. "Induced Pluripotent Stem Cells." In Essential Current Concepts in Stem Cell Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33923-4_7.

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Conference papers on the topic "Pluripotent Stem Cells (PSCs)"

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"Designing tumorigenicity tests for pluripotent stem cell (PSC)-derived cell products." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.88.

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Alsallum, A. "REPROGRAMMING OF SOMATIC CELLS INTO PLURIPOTENT STEM CELLS:." In Конференция «Перспективы применения генной терапии и биомедицинского клеточного продукта» с блоком летней школы для молодых ученых. Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр эндокринологии» Министерства здравоохранения Российской Федерации, 2022. http://dx.doi.org/10.14341/gnct-2022-43.

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Hookway, Tracy A., Doan Nguyen, Chunhui Xu, Mary B. Wagner, and Todd C. McDevitt. "Engineering cardiospheres from human pluripotent stem cells." In 2014 40th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2014. http://dx.doi.org/10.1109/nebec.2014.6972817.

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Hay, David. "Building Implantable Human Liver Tissue from Pluripotent Stem Cells." In Cells 2023. MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021016.

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Uchugonova, Aisada, Ana Batista, and Karsten König. "Fluorescence lifetime imaging of induced pluripotent stem cells." In SPIE BiOS, edited by Ammasi Periasamy, Peter T. C. So, and Karsten König. SPIE, 2014. http://dx.doi.org/10.1117/12.2037662.

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Hawkins, Finn J., Tyler A. Longmire, Laertis Ikonomou, Jeremy Song, Harald Ott, and Darrell N. Kotton. "Derivation Of Lung Progenitors From Pluripotent Stem Cells." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6534.

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OKANO, HIDEYUKI. "STRATEGIES TOWARD CNS-REGENERATION USING INDUCED PLURIPOTENT STEM CELLS." In Proceedings of the 20th International Conference. PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO., 2009. http://dx.doi.org/10.1142/9781848165632_0022.

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Wang, R., P. Agrawal, T. Schlaeger, et al. "Modeling Cystic Fibrosis (CF) with Induced Pluripotent Stem Cells." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6401.

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Holy, J., E. Perkins, and Xun Yu. "Differentiation of pluripotent stem cells on multiwalled carbon nanotubes." In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5333699.

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Wang, Xinglie, Jinqi Liao, Guanghui Yue, et al. "Induced Pluripotent Stem Cells Detection via Ensemble Yolo Network." In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9629744.

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Reports on the topic "Pluripotent Stem Cells (PSCs)"

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Ying, Mingyao. Modeling Aggressive Medulloblastoma Using Human-Induced Pluripotent Stem Cells. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada620932.

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Chernoff, Jonathan. Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada564162.

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Donohue, Henry J., Christopher Niyibizi, and Alayna Loiselle. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada606237.

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Donahue, Henry J. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581680.

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Peehl, Donna M. Identification of Epigenetic Changes in Prostate Cancer using Induced Pluripotent Stem Cells. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580354.

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Peehl, Donna. Identification of Epigenetic Changes in Prostate Cancer Using Induced Pluripotent Stem Cells. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada544181.

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Heo, Y., Y. Xu, X. Quan, Y. Seong, N. Kim, and J. Kim. CRISPR/Cas9 nuclease-mediated gene knock-in in bovine pluripotent stem cells and embryos. Cold Spring Harbor Laboratory, 2014. http://dx.doi.org/10.1101/005421.

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Setaluri, Vijayasaradhi. Differentiation of Neonatal Human-Induced Pluripotent Stem Cells to Prostate Epithelial Cells: A Model to Study Prostate Cancer Development. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada609443.

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Setaluri, Vijayasaradhi. Differentiation of Neonatal Human-Induced Pluripotent Stem Cells to Prostate Epithelial Cells: A Model to Study Prostate Cancer Development. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada583418.

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Gupta, Shweta. The Revolution of Human Organoids in Cell Biology. Natur Library, 2020. http://dx.doi.org/10.47496/nl.blog.12.

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Organoids are a new research tool derived from human pluripotent or adult stem cells or somatic cells in vitro to form small, self-organizing 3-dimensional structures that simulate many of the functions of native organs

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