Academic literature on the topic 'PlxnA1'

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Journal articles on the topic "PlxnA1"

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Zhang, Xiaoli, Shuai Shao, and Lang Li. "Characterization of Class-3 Semaphorin Receptors, Neuropilins and Plexins, as Therapeutic Targets in a Pan-Cancer Study." Cancers 12, no. 7 (2020): 1816. http://dx.doi.org/10.3390/cancers12071816.

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Class-3 semaphorins (SEMA3s), initially characterized as axon guidance cues, have been recognized as key regulators for immune responses, angiogenesis, tumorigenesis and drug responses. The functions of SEMA3s are attributed to the activation of downstream signaling cascades mainly mediated by cell surface receptors neuropilins (NRPs) and plexins (PLXNs), yet their roles in human cancers are not completely understood. Here, we provided a detailed pan-cancer analysis of NRPs and PLXNs in their expression, and association with key signal transducers, patient survival, tumor microenvironment (TME
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Kuroiwa, A., F. Suto, H. Fujisawa, and Y. Matsuda. "Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster." Cytogenetic and Genome Research 92, no. 1-2 (2001): 127–29. http://dx.doi.org/10.1159/000056882.

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Miyamoto, Yuji, Fotios Loupakis, Wu Zhang, et al. "Genetic variations in semaphorin/neuropilin signaling to predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) receiving bevacizumab-based chemotherapy." Journal of Clinical Oncology 35, no. 15_suppl (2017): 11608. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.11608.

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11608 Background: Neuropilin ( NRP) is known to be an important VEGF co-receptor that acts as a key mediator of angiogenesis. Its ligands, semaphorins ( SEMA), compete with VEGF for NRP binding and can themselves have angiogenic activity. Plexins are also receptors of SEMAs, and have the GTPase activating proteins (GAPs) domain for RAS. NRPs are shown to signal through RAS pathways. We aimed to evaluate whether single nucleotide polymorphisms (SNPs) of genes involved in the SEMA/NRPpathways predict clinical outcome in bevacizumab-treated mCRC pts. Methods: Associations between nine SNPs in 7 g
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Park, Sangwook, Ji-Eun Oh, and Hyun-Seok Jin. "Recapitulation of the Genetic Association of PLXNA2 with Bone Density and Osteoporosis via In Vitro Experiments Using a Korean Female Cohort." Journal of Medical Imaging and Health Informatics 10, no. 6 (2020): 1418–22. http://dx.doi.org/10.1166/jmihi.2020.3064.

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Osteoporosis is a bone disorder in which the imbalance of osteoclasts and osteoblasts leads to bone-destructive diseases especially among elderly women. Several factors, including genetic and environmental factors, contribute to the pathogenesis of these diseases. Bone mineral density (BMD) is a robust factor that influences osteoporosis; the development of osteoporosis in the elderly is estimated based on the BMD. Our previous microarray assay using murine preosteoblast cells revealed that Plexin A2 is associated with the differentiation and mineralization of bone-forming osteoblasts via bone
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Oleari, Roberto, Alessia Caramello, Sara Campinoti, et al. "PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons." Development 146, no. 21 (2019): dev176461. http://dx.doi.org/10.1242/dev.176461.

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Dormon, Katherine, Elda S. Latif, Matthew Bashton, et al. "A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse." Blood 126, no. 23 (2015): 2619. http://dx.doi.org/10.1182/blood.v126.23.2619.2619.

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Abstract Although paediatric acute lymphoblastic leukaemia (ALL) has a favourable prognosis, a number of cases will invariably relapse. One of the major problems associated with relapse is drug resistance, in particular to glucocorticoids, the mainstay of ALL treatment. Examining the underlying mechanisms is complicated by clonal heterogeneity within a patient and the potential impact of the leukaemic niche. To address mechanisms of drug resistance in a patient-relevant setting, we performed a genome-wide in vivo CRISPR screen in primary ALL material. To that end, we took advantage of primogra
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Wang, Laidi, Wenshuang Liang, Shasha Wang, et al. "Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation." PLOS ONE 15, no. 7 (2020): e0236069. http://dx.doi.org/10.1371/journal.pone.0236069.

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Kotan, Leman D., Emregul Isik, Ihsan Turan, et al. "Prevalence and associated phenotypes of PLXNA1 variants in normosmic and anosmic idiopathic hypogonadotropic hypogonadism." Clinical Genetics 95, no. 2 (2018): 320–24. http://dx.doi.org/10.1111/cge.13482.

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Park, Kaylee, Laurie E. Seltzer, Emily Tuttle, Ghayda M. Mirzaa, and Alex R. Paciorkowski. "PLXNA1 developmental encephalopathy with syndromic features: A case report and review of the literature." American Journal of Medical Genetics Part A 173, no. 7 (2017): 1951–54. http://dx.doi.org/10.1002/ajmg.a.38236.

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Wang, Wei-Wei, Zhi-Hua Zhao, Li Wang, et al. "MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway." EBioMedicine 46 (August 2019): 66–78. http://dx.doi.org/10.1016/j.ebiom.2019.07.050.

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Dissertations / Theses on the topic "PlxnA1"

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Pignata, Aurora. "Study of the spatio-temporal dynamics of guidance receptors during commissural axon navigation in the spinal cord." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1286/document.

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Les commissures forment un ensemble de connexions nerveuses assurant la communication entre les neurones de chaque hémi partie du système nerveux central des bilatériens. Au cours du développement embryonnaire, les axones des neurones commissuraux sont guidés au travers de la ligne médiane délimitant ces deux parties. Plusieurs sources de signaux de guidage attractifs et répulsifs agissent de concert pour organiser les trajectoires de ces axones. Dans la moelle épinière, les axones commissuraux traversent la ligne médiane dans un territoire ventral, la plaque du plancher (PP). Au cours de la t
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Favrot, Clémentine. "Développement d’une thérapie ciblée anticancéreuse dirigée contre le couple SEMA3E/PLXND1." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1094.

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Les protéines Sémaphorines et leurs récepteurs Plexines jouent un rôle primordial dans le réseau de signalisation cellulaire. Initialement découvertes pour leur rôle dans le guidage axonal, il fut rapidement mis en lumière qu'elles étaient également impliquées dans le développement du système cardiovasculaire, dans la tumorigénèse et le fonctionnement du système immunitaire, démontrant les multiples facettes de ces protéines. Parmi ces couples de ligands et de récepteurs, la Sémaphorine 3E et son récepteur Plexine D1 représentent des cibles d'intérêt pour les thérapies anti-cancéreuses. La Sém
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Stahl, Immanuel Georg [Verfasser], Juliane [Akademischer Betreuer] [Gutachter] Winkelmann, and Bernhard [Gutachter] Haslinger. "Genetische Varianten in PLXNA4 bei Morbus Parkinson / Immanuel Georg Stahl ; Gutachter: Juliane Winkelmann, Bernhard Haslinger ; Betreuer: Juliane Winkelmann." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1135724849/34.

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Book chapters on the topic "PlxnA1"

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"PLXN." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_101850.

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"Plx1." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102996.

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"PLXN." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_4640.

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"Plx1." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_13055.

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