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Journal articles on the topic 'PMEPA1'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Rakhmatullina, Aigul R., Mariya A. Zolotykh, Yuliya V. Filina, et al. "In Vitro Analysis of PMEPA1 Upregulation in Mesenchymal Stem Cells Induced by Prostate Cancer Cells." International Journal of Molecular Sciences 26, no. 13 (2025): 6223. https://doi.org/10.3390/ijms26136223.

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Isoforms of prostate transmembrane protein, androgen induced 1 (PMEPA1), are regulated either by TGF-beta or AR activation and provide negative loop-regulation of these signaling pathways. High levels of PMEPA1 protein have been observed in various tumor types, including prostate, bladder, colorectal cancers, and glioblastoma. Direct oncogenic role of PMEPA1 in hepatocellular carcinoma has been recently shown on an animal model. New studies also indicate an upregulation of PMEPA1 in tumor-associated immune and stromal cells; however, its specific role in tumor stromal cells remains largely une

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2

Sharad, Shashwat, ZsÃ£Â³fia Sztupinszki, Zoltan Szallasi, et al. "PMEPA1 gene isoforms to indicate disease progression in solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): e16580-e16580. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e16580.

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e16580 Background: Dysfuncitons of androgen and TGF-β signaling play important roles in prostate tumorigenesis. PMEPA1 gene has been defined as an androgen and TGF-β responsive gene which inhibits androgen and TGF-β signaling via negative feed-back loops. Our previous data has established that PMEPA1 distinct isoforms ( PMEPA1-a and PMEPA1-b) with disparities within N-terminus protein sequences navigate different androgen/TGF-β signaling regulations. In this study, the roles of PMEPA1 isoforms in disease progressions were investigated in solid tumors of prostate (CaP), breast, lung and colon.

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3

Ji, Jianxiong, Kaikai Ding, Tao Luo, et al. "PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1." Oncogene 39, no. 5 (2019): 1125–39. http://dx.doi.org/10.1038/s41388-019-1050-9.

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Abstract The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane protein, prostate transmembrane protein, androgen induced 1 (PMEPA1) with large tumor suppressor kinase 1 (LATS1). We show that PMEPA1 is upregulated in primary human gliomas. The PMEPA1 isoform PMEPA1a was predominantly expressed in glioma specimens and cell lines, and ectopic expression of the protein promoted glioma growth and invasion in vitro and in an ort

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4

Li, Jing, and Wei-min Kong. "PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer." Journal of Immunology Research 2022 (April 20, 2022): 1–11. http://dx.doi.org/10.1155/2022/4510462.

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Emerging studies have demonstrated that Prostate transmembrane protein androgen induced 1 (PMEPA1) plays crucial roles in the carcinogenesis of many developing human tumors. However, the clinical significance of PMEPA1 expression in cervical cancer (CC) and its contribution to cancer immunity have not been investigated. In this study, we identified PMEPA1 as a survival-related gene in CC based on TCGA datasets. Univariate and multivariate analysis showed that PMEPA1 expression was an independent predictor for overall survival in CC patients. We could observe a strong negative correlation betwe

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5

Sharad, Shashwat, Zsófia M. Sztupinszki, Yongmei Chen та ін. "Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer". Cancers 11, № 12 (2019): 1995. http://dx.doi.org/10.3390/cancers11121995.

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Dysfunctions of androgen/TGF-β signaling play important roles in prostate tumorigenesis. Prostate Transmembrane Protein Androgen Induced 1 (PMEPA1) inhibits androgen and TGF-β signaling via a negative feedback loop. The loss of PMEPA1 confers resistance to androgen signaling inhibitors and promotes bone metastasis. Conflicting reports on the expression and biological functions of PMEPA1 in prostate and other cancers propelled us to investigate isoform specific functions in prostate cancer (PCa). One hundred and twenty laser capture micro-dissection matched normal prostate and prostate tumor ti

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6

Spahn, Martin, Eugenio Zoni, Markus Krebs, et al. "miR-221 to modulate tumor growth in vivo and as a regulator of TGF." Journal of Clinical Oncology 35, no. 15_suppl (2017): e23008-e23008. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23008.

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e23008 Background: Despite the advances in cancer therapy, when Prostate Cancer (PCa) progress to castration resistant phase, patients develop incurable bone metastases. Understanding the processes that regulate homing and survival of metastatic cancer cells in the bone is crucial for the identification of new therapies. TGF-β signaling plays a major role in bone remodeling and according to the “vicious cycle hypothesis” is a master regulator of maintenance of prostate cancer cells in lytic bone lesions. microRNAs (miRs) are a class of small non-coding RNAs that regulates many biological proce

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7

Piqué-Gili, Marta, Carmen Andreu-Oller, Roser Pinyol та ін. "Abstract PR02: PMEPA1 has an oncogenic role in the context of TGF-β signaling in hepatocellular carcinoma". Clinical Cancer Research 28, № 17_Supplement (2022): PR02. http://dx.doi.org/10.1158/1557-3265.liverca22-pr02.

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Abstract Background: Transforming growth factor β (TGFβ) has a dual role in cancer, including hepatocellular carcinoma (HCC). It acts as a tumor suppressor in early stages of hepatocarcinogenesis, but promotes epithelial-to-mesenchymal transition, angiogenesis and immunosuppression in advanced stages. PMEPA1 (prostate transmembrane protein androgen induced 1) negatively regulates TGFβ signaling by interacting with SMAD proteins, and has been shown to promote TGFβ oncogenic effects in other cancers. Thus, we aimed to explore the role of PMEPA1 in HCC pathogenesis. Methods: We analyzed transcrip

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8

Piqué-Gili, Marta, Carmen Andreu-Oller, Roser Pinyol та ін. "Abstract 840: PMEPA1 is an oncogene linked to TGF-β signaling in hepatocellular carcinoma". Cancer Research 82, № 12_Supplement (2022): 840. http://dx.doi.org/10.1158/1538-7445.am2022-840.

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Abstract Background: Transforming growth factor β (TGFβ) has a dual role in cancer, including hepatocellular carcinoma (HCC). It acts as a tumor suppressor in early stages of hepatocarcinogenesis, but promotes epithelial-to-mesenchymal transition, angiogenesis and immunosuppression in advanced stages. PMEPA1 (prostate transmembrane protein androgen induced 1), a direct target gene of the TGFβ pathway that negatively regulates TGFβ signaling by interacting with SMAD proteins, has been shown to promote TGFβ oncogenic effects in other cancers and we decided to explore its role in HCC pathogenesis

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9

Sharad, Shashwat, and Hua Li. "Abstract A006: Loss of PMEPA1 gene isoform facilitates the development of hormone and radiation therapies resistance in prostate cancer cells." Cancer Research 83, no. 11_Supplement (2023): A006. http://dx.doi.org/10.1158/1538-7445.prca2023-a006.

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Abstract Introduction: Nearly all the patients receiving hormone treatment eventually progress into castration resistance stage. In addition, approximately 30% to 40% of patients receiving radiation treatment will develop resistance. The aberrant alterations of androgen receptor (AR) and transforming growth factor-β (TGF-β) signaling play critical roles in such processes. Our studies identified five PMEPA1 (Prostate Transmembrane Protein Androgen Induced 1) gene isoforms in prostate cancer cells. PMEPA1-b isoform was androgen responsive and inhibited androgen signaling. In contrast, PMEPA1 iso

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10

Sharad, Shashwat, Albert Dobi, Shiv Srivastava, Alagarsamy Srinivasan, and Hua Li. "PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer." Biomolecules 10, no. 9 (2020): 1221. http://dx.doi.org/10.3390/biom10091221.

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The identification of prostate transmembrane protein androgen induced 1 (PMEPA1), an androgen responsive gene, came initially from the studies of androgen regulatory gene networks in prostate cancer. It was soon followed by the documentation of the expression and functional analysis of transmembrane prostate androgen-induced protein (TMEPAI)/PMEPA1 in other solid tumors including renal, colon, breast, lung, and ovarian cancers. Further elucidation of PMEPA1 gene expression and sequence analysis revealed the presence of five isoforms with distinct extracellular domains (isoforms a, b, c, d, and

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11

Almutairi, Farooq M. "MicroRNA-19a-3p Regulates Abdominal Aneurysm Development and Progression via Direct Interaction with PMEPA1." Journal of Pioneering Medical Science 13, no. 5 (2024): 52–55. http://dx.doi.org/10.61091/jpms202413509.

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Background: Abdominal aneurysm (AA) is a fatal disease with high mortality rates. The therapeutic approaches and roles of microRNAs (miRNAs) and messenger RNA (mRNA) in the treatment of AA have previously been explored. Objective: The aim of the study was to investigate the influence of microRNA-19a-3p on PMEPA1 in the moderation of AA development and advancement. Materials and Methods: Quantitative Real Time-PCR was utilized to analyze the expression of microRNA-19a-3p and PMEPA1 in expanded vascular smooth muscle cells (VSMCs). Gene expression was modulated through cell transfection, either

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12

Wen, Fei, Shangyu Yang, WeiWen Cai, Mengyuan Zhao, Long Qin, and Zuoyi Jiao. "Exploring the role of PMEPA1 in gastric cancer." Molecular and Cellular Probes 72 (December 2023): 101931. http://dx.doi.org/10.1016/j.mcp.2023.101931.

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13

Khatib, Tala O., Brian A. Pedro, Christina M. Knippler, et al. "Abstract 1271: PMEPA1 acts as a switch to modulate cooperative cellular invasion and drive NSCLC tumor progression." Cancer Research 84, no. 6_Supplement (2024): 1271. http://dx.doi.org/10.1158/1538-7445.am2024-1271.

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Abstract Metastatic disease drives cancer patient mortality. One primary mode of metastasis is collective invasion, whereby cohesive groups of cells invade into the adjacent stroma while maintaining cell-cell contacts. Importantly, these cellular packs harbor genetically and phenotypically heterogeneous subpopulations that cooperate to drive invasion. To deconstruct how phenotypic cellular heterogeneity facilitates distinct molecular profiles within a single tumor, we established the technique Spatiotemporal Cellular and Genomic Analysis (SaGA). SaGA is an image-guided approach that optically

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14

Kakumani, Pavan Kumar, Tanit Guitart, Francois Houle, et al. "CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma." Oncogene 40, no. 18 (2021): 3231–44. http://dx.doi.org/10.1038/s41388-021-01767-9.

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15

Stone, Louise. "TGF-β signalling regulator PMEPA1 halts metastases to bone". Nature Reviews Urology 12, № 7 (2015): 362. http://dx.doi.org/10.1038/nrurol.2015.136.

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16

Blee, Alexandra M., та Haojie Huang. "PMEPA1 guards against TGF-β-mediated prostate cancer bone metastasis". Asian Journal of Urology 3, № 1 (2016): 1–3. http://dx.doi.org/10.1016/j.ajur.2015.11.002.

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17

Andreu-Oller, Carmen, Marta Piqué-Gili, Marina Barcena-Varela, et al. "PMEPA1: an oncogene in hepatocellular carcinoma linked to TGF-beta signaling." Journal of Hepatology 77 (July 2022): S45—S46. http://dx.doi.org/10.1016/s0168-8278(22)00501-3.

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18

Fournier, Pierrick G. J., Patricia Juárez, Guanglong Jiang та ін. "The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone". Cancer Cell 27, № 6 (2015): 809–21. http://dx.doi.org/10.1016/j.ccell.2015.04.009.

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19

Link, Andrea S., Svitlana Kurinna, Steven Havlicek, et al. "Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling." Molecular Neurobiology 53, no. 6 (2015): 4210–25. http://dx.doi.org/10.1007/s12035-015-9363-3.

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20

Quetglas, I. M., D. Sia, Y. Jiao та ін. "TGF-β oncogenic pathway in HCC: PMEPA1 as a biomarker of treatment response". Journal of Hepatology 66, № 1 (2017): S466. http://dx.doi.org/10.1016/s0168-8278(17)31318-1.

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21

Zhang, Lei, Xue Wang, Chong Lai, Honghe Zhang та Maode Lai. "PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancer". Journal of Cellular and Molecular Medicine 23, № 5 (2019): 3603–15. http://dx.doi.org/10.1111/jcmm.14261.

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22

Funakubo, Noboru, Xianghe Xu, Toshio Kukita, Seiji Nakamura, Hiroshi Miyamoto, and Akiko Kukita. "Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis." Journal of Cellular Physiology 233, no. 4 (2017): 3105–18. http://dx.doi.org/10.1002/jcp.26147.

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23

FENG, SUJUAN, XUHUI ZHU, BOHAN FAN, DAWEI XIE, TAO LI, and XIAODONG ZHANG. "miR-19a-3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion." Molecular Medicine Reports 13, no. 5 (2016): 4030–38. http://dx.doi.org/10.3892/mmr.2016.5033.

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24

Sharad, Shashwat, Hua Li, Michael C. Haffner, et al. "Abstract B6: Epigenetic regulation of the androgen receptor regulator PMEPA1 in prostate cancer cells." Cancer Research 72, no. 4 Supplement (2012): B6. http://dx.doi.org/10.1158/1538-7445.prca2012-b6.

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25

Wang, Bin, Jun-Long Zhong, Hui-Zi Li, et al. "Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer." Life Sciences 277 (July 2021): 119452. http://dx.doi.org/10.1016/j.lfs.2021.119452.

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26

Li, Hua, Ahmed A. Mohamed, Shashwat Sharad, et al. "Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN." Oncotarget 6, no. 17 (2015): 15137–49. http://dx.doi.org/10.18632/oncotarget.3526.

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27

Nie, Zhi, Chunyan Wang, Zhongmei Zhou, Ceshi Chen, Rong Liu, and Dianhua Wang. "Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression." Acta Biochimica et Biophysica Sinica 48, no. 2 (2016): 194–201. http://dx.doi.org/10.1093/abbs/gmv130.

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28

Raymundo, Eliza, Li Hongyun, Linda Xu, et al. "PMEPA1-AR DEGRADATION PATHWAY: A NEW MECHANISM FOR THE REGULATION OF ANDROGEN RECEPTOR IN PROSTATE CANCER." Journal of Urology 181, no. 4S (2009): 510. http://dx.doi.org/10.1016/s0022-5347(09)61440-3.

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29

Dijkstra, Johannes M., and David B. Alexander. "The “NF-ĸB interacting long noncoding RNA” (NKILA) transcript is antisense to cancer-associated gene PMEPA1." F1000Research 4 (April 22, 2015): 96. http://dx.doi.org/10.12688/f1000research.6400.1.

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This correspondence concerns a recent publication inCancer Cellby Liu et al.1 who analyzed a long noncoding RNA (lncRNA) that they designated “NKILA”. Liu et al. found thatNKILA(1) is upregulated by immunostimulants, (2) has a promoter with an NF-ĸB binding motif, (3) can bind to the p65 protein of the NF-ĸB transcription factor and then interfere with phosphorylation of IĸBα, and (4) negatively affects functions that involve NF-ĸB pathways. And, importantly, they found that (5) lowNKILAexpression in breast cancers is associated with poor patient prognosis. However, they entirely failed to men

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30

Rae, Fiona K., John D. Hooper, David L. Nicol, and Judith A. Clements. "Characterization of a novel gene,STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors." Molecular Carcinogenesis 32, no. 1 (2001): 44–53. http://dx.doi.org/10.1002/mc.1063.

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31

Xu, Linda L., Naga Shanmugam, Takehiko Segawa, et al. "A Novel Androgen-Regulated Gene, PMEPA1, Located on Chromosome 20q13 Exhibits High Level Expression in Prostate." Genomics 66, no. 3 (2000): 257–63. http://dx.doi.org/10.1006/geno.2000.6214.

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32

Xu, Linda L., Naga Shanmugam, Takehiko Segawa, et al. "A Novel Androgen-Regulated Gene, PMEPA1, Located on Chromosome 20q13 Exhibits High Level Expression in Prostate." Genomics 70, no. 3 (2000): 407. http://dx.doi.org/10.1006/geno.2000.6458.

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33

Zhu, Lu, Jing Jing, Shuaiqi Qin, et al. "miR-130a-3p regulates steroid hormone synthesis in goat ovarian granulosa cells by targeting the PMEPA1 gene." Theriogenology 165 (April 2021): 92–98. http://dx.doi.org/10.1016/j.theriogenology.2021.02.012.

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34

Li, Hongyun, Linda L. Xu, Katsuaki Masuda, et al. "A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells." Journal of Biological Chemistry 283, no. 43 (2008): 28988–95. http://dx.doi.org/10.1074/jbc.m710528200.

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35

Puteri, Meidi U., Yukihide Watanabe, Bantari W. K. Wardhani, Riezki Amalia, Mohammed Abdelaziz, and Mitsuyasu Kato. "PMEPA1/TMEPAI isoforms function via its PY and Smad‐interaction motifs for tumorigenic activities of breast cancer cells." Genes to Cells 25, no. 6 (2020): 375–90. http://dx.doi.org/10.1111/gtc.12766.

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36

Cardillo, M. R., and F. Di Silverio. "Prostate — Specific G Protein Couple Receptor Genes and STAG1/PMEPA1 in Peripheral Blood from Patients with Prostatic Cancer." International Journal of Immunopathology and Pharmacology 19, no. 4 (2006): 871–78. http://dx.doi.org/10.1177/039463200601900416.

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37

Koido, Masaru, Junko Sakurai, Satomi Tsukahara, Yuri Tani та Akihiro Tomida. "PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors". Biochemical and Biophysical Research Communications 479, № 4 (2016): 615–21. http://dx.doi.org/10.1016/j.bbrc.2016.09.166.

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38

Wang, Peng, Haiyang Zhang, Zilian Cui, Xunbo Jin, and Dong Zhang. "Mir-612 Inhibits Proliferation and Invasion of Urothelial Carcinoma of Bladder Cells through Activating Hippo Pathway via Targeting PMEPA1." Oncologie 23, no. 2 (2021): 259–68. http://dx.doi.org/10.32604/oncologie.2021.015503.

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39

Amalia, Riezki, Mohammed Abdelaziz, Meidi Utami Puteri та ін. "TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells". Cellular Signalling 59 (липень 2019): 24–33. http://dx.doi.org/10.1016/j.cellsig.2019.03.016.

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40

Haque, Md Anwarul, Mohammed Abdelaziz, Meidi Utami Puteri, et al. "PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells." Cancers 13, no. 19 (2021): 4934. http://dx.doi.org/10.3390/cancers13194934.

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Transmembrane prostate androgen-induced protein (TMEPAI), also known as PMEPA1, is highly expressed in many types of cancer and promotes oncogenic abilities. However, the mechanisms whereby TMEPAI facilitates tumorigenesis are not fully understood. We previously established TMEPAI-knockout (KO) cells from human triple-negative breast cancer (TNBC) cell lines and found that TMEPAI-KO cells showed reduced tumorigenic abilities. Here, we report that TMEPAI-KO cells upregulated the expression of pleckstrin homology (PH) domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) and suppressed A

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41

Sun, Yingjie, Yuheng Tang, Qi Qi, et al. "101 Machine Learning Algorithms for Mining Esophageal Squamous Cell Carcinoma Neoantigen Prognostic Models in Single-Cell Data." International Journal of Molecular Sciences 26, no. 7 (2025): 3373. https://doi.org/10.3390/ijms26073373.

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Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the digestive tract, characterized by a high recurrence rate and inadequate immunotherapy options. We analyzed mutation data of ESCC from public databases and employed 10 machine learning algorithms to generate 101 algorithm combinations. Based on the optimal range determined by the concordance index, we randomly selected one combination from the best-performing algorithms to construct a prognostic model consisting of five genes (DLX5, MAGEA4, PMEPA1, RCN1, and TIMP1). By validating the correlation betw

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42

Abdelaziz, Mohammed, Yukihide Watanabe, and Mitsuyasu Kato. "PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth." Journal of Biochemistry 165, no. 5 (2019): 411–14. http://dx.doi.org/10.1093/jb/mvz022.

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43

Azami, Shun, Thanh Thao Vo Nguyen, Yukihide Watanabe та Mitsuyasu Kato. "Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling". Biochemical and Biophysical Research Communications 456, № 2 (2015): 580–85. http://dx.doi.org/10.1016/j.bbrc.2014.11.107.

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44

Liu, Rong, Zhongmei Zhou, Jian Huang, and Ceshi Chen. "PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21$^{{\rm Cip1}}$ signaling pathway." Journal of Pathology 223, no. 5 (2011): 683–94. http://dx.doi.org/10.1002/path.2834.

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45

Reichling, Tim, Kathleen Heppner Goss, Daniel J. Carson, et al. "Transcriptional Profiles of Intestinal Tumors in Apc Min Mice are Unique from those of Embryonic Intestine and Identify Novel Gene Targets Dysregulated in Human Colorectal Tumors." Cancer Research 65, no. 1 (2005): 166–76. http://dx.doi.org/10.1158/0008-5472.166.65.1.

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Abstract The adenomatous polyposis coli (APC) tumor suppressor is a major regulator of the Wnt signaling pathway in normal intestinal epithelium. APC, in conjunction with AXIN and GSK-3β, forms a complex necessary for the degradation of β-catenin, thereby preventing β-catenin/T-cell factor interaction and alteration of growth-controlling genes such as c-MYC and cyclin D1. Inappropriate activation of the Wnt pathway, via Apc/APC mutation, leads to gastrointestinal tumor formation in both the mouse and human. In order to discover novel genes that may contribute to tumor progression in the gastro

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46

Agoulnik, Irina U., William E. Bingman, Manjula Nakka, et al. "Target Gene-Specific Regulation of Androgen Receptor Activity by p42/p44 Mitogen-Activated Protein Kinase." Molecular Endocrinology 22, no. 11 (2008): 2420–32. http://dx.doi.org/10.1210/me.2007-0481.

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Abstract Evidence that the androgen receptor (AR) is not only important in androgen-dependent prostate cancer, but also continues to play a role in tumors that become resistant to androgen deprivation therapies, highlights the need to find alternate means to block AR activity. AR, a hormone-activated transcription factor, and its coactivators are phosphoproteins. Thus, we sought to determine whether inhibition of specific cell signaling pathways would reduce AR function. We found that short-term inhibition of p42/p44 MAPK activity either by a MAPK kinase inhibitor, U0126, or by depletion of ki

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47

Yin, Kathleen, Jennifer R. Deuis, Zoltan Dekan, et al. "Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7." Biomedicines 8, no. 2 (2020): 37. http://dx.doi.org/10.3390/biomedicines8020037.

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Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (NaV). Here, we describe the discovery of μ-theraphotoxin-Pme1a and μ/δ-theraphotoxin-Pme2a, two novel peptides from the venom of the Gooty Ornamental tarantula Poecilotheria metallica that modulate NaV channels. Pme1a is a 35 residue peptide that inhibits NaV1.7 peak current (IC50 334 ± 114 nM) and shifts the voltage dependence of activation to more depolarised membrane potentials (V1/2 activation: Δ = +11.6 mV). Pme2a is a 33 residue peptide that delays fast inactivat

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48

Zhang, Yan, Huayun Zhu, Ning Sun, et al. "Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression." Aging 13, no. 13 (2021): 17830–46. http://dx.doi.org/10.18632/aging.203286.

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49

Li, Hua, Albert Dobi, and Shiv Srivastava. "Abstract A4: Androgen receptor (AR) degradation is controlled by the co-operation of PMEPA1 and the E3 ubiquitin ligase NEDD4-1." Cancer Research 72, no. 4 Supplement (2012): A4. http://dx.doi.org/10.1158/1538-7445.prca2012-a4.

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Yu, Hao, Juntao Zhuang, Zijian Zhou, et al. "METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway." International Journal of Biological Sciences 20, no. 4 (2024): 1471–91. http://dx.doi.org/10.7150/ijbs.86719.

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