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Journal articles on the topic 'PMNC'

Author: Grafiati

Published: 4 May 2024

Last updated: 31 July 2025

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1

Wickström, Erik, Karin Persson-Waller, Helena Lindmark-Månsson, Karin Östensson, and Åse Sternesjö. "Relationship between somatic cell count, polymorphonuclear leucocyte count and quality parameters in bovine bulk tank milk." Journal of Dairy Research 76, no. 2 (2009): 195–201. http://dx.doi.org/10.1017/s0022029909003926.

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The somatic cell count (SCC) in bovine bulk tank milk is presently used as an indicator of raw milk quality, reflecting the udder health status of the herd. During mastitis, SCC increases, mostly owing to an influx of polymorphonuclear leucocytes (PMN) from blood into milk, with a concomitant change in milk composition. Bulk tank milk samples were categorized according to their SCC, as well as polymorphonuclear leucocyte count (PMNC), to study relationships between SCC, PMNC and various raw milk quality traits, i.e. contents of total protein, whey protein, casein, fat and lactose, casein numbe

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Miyamoto, Koji, Michael Lange, George McKinley, et al. "Effects of Sho-Saiko-To on Production of Prostaglandin E2 (PGE2), Leukotriene B4 (LTB4) and Superoxide from Peripheral Monocytes and Polymorphonuclear Cells Isolated from HIV Infected Individuals." American Journal of Chinese Medicine 24, no. 01 (1996): 1–10. http://dx.doi.org/10.1142/s0192415x96000025.

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The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE2 from monocytes, LTB4 and superoxide from polymorphonuclear cells (PMNC) in HIY infected individuals were studied. SST inhibited the production of PGE2 from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB4 when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on th

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Ilham, Ainun Isnaeni, Arni Irawaty Djais, Asdar Gani, Sri Oktawati, Dian Setiawati, and Surijana Mappangara. "Effectiveness of calcium carbonate from non-cultivated pearl oyster shells (Pinctada Maxima) in socket preservation." Acta Marisiensis - Seria Medica 71, no. 1 (2025): 73–77. https://doi.org/10.2478/amma-2025-0006.

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Abstract Introduction: One of the marine biota that can be used as an alternative for bone regeneration is the non-cultivated pearl oyster shell (Pinctada maxima). Calcium carbonate found in the Nacre layer has biocompatible, biodegradable, and osteogenic properties, thereby encouraging bone formation. Objective: to investigate the impact of calcium carbonate derived from Pinctada maxima non-cultivated (PMNC) on socket preservation, focusing on RANKL expression. Method: Using experimental laboratory research tests and clinical trials with a post-test only control group design. Mandibular right

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Weiss, Mauricio Andrade, and Adriano Vilela Sampaio. "Políticas monetárias não convencionais nos EUA: análise empírica do período 2007-2019." Revista de Economia 43, no. 80 (2022): 241. http://dx.doi.org/10.5380/re.v43i80.75974.

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O objetivo do presente artigo é analisar a eficácia das políticas monetárias não convencionais (PMNC) adotadas nos EUA após a crise de 2008, considerando sua capacidade de criar condições acomodatícias nos mercados financeiros e promover o emprego, sem prejudicar a estabilidade de preços. A hipótese a ser testada é de que em uma situação de alta instabilidade e baixas taxas de juros, os instrumentos não convencionais se mostraram eficazes diante dos objetivos propostos. Foram empregados testes de causalidade de Granger para avaliar a relação entre os instrumentos de PMNC e os objetivos interme

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Aiboud, Kada. "politiques monétaires non conventionnelles et la relance économique : étude de la politique de l’assouplissement quantitatif en Algérie." les cahiers du cread 39, no. 4 (2024): 175–203. http://dx.doi.org/10.4314/cread.v39i4.7.

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Le présent article traite des politiques monétaires non conventionnelles (PMNC) mises en œuvre par la Fed et la BCE, entre 2008 et 2014, face à la récession économique et la déflation engendrées par la crise financière de 2008. Il consiste à rendre compte, en suivant une approche descriptive fondée sur l'examen de nombreuses études sur les PMNC, des mesures d'assouplissement monétaires traditionnelles servant, d’une part, à influencer les conditions de financement dans les banques et les marchés financiers et, d’autre part, à favoriser la demande globale et à stimuler l'activité économique. Ce

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Löppönen, Pekka, Sina Hulkkonen, and Jorma Ryhänen. "Proximal Median Nerve Compression in the Differential Diagnosis of Carpal Tunnel Syndrome." Journal of Clinical Medicine 11, no. 14 (2022): 3988. http://dx.doi.org/10.3390/jcm11143988.

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Carpal tunnel syndrome (CTS) is the most common median nerve compression neuropathy. Its symptoms and clinical presentation are well known. However, symptoms at median nerve distribution can also be caused by a proximal problem. Pronator syndrome (PS) and anterior interosseous nerve syndrome (AINS) with their typical characteristics have been thought to explain proximal median nerve problems. Still, the literature on proximal median nerve compressions (PMNCs) is conflicting, making this classic split too simple. This review clarifies that PMNCs should be understood as a spectrum of mild to sev

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Reyna, Sara M., Puntip Tantiwong, Eugenio Cersosimo, Ralph A. DeFronzo, Apiradee Sriwijitkamol, and Nicolas Musi. "Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects." Journal of Diabetes Research 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/107805.

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Background. Exercise has an anti-inflammatory effect against, and immune cells play critical roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD). Thus, the goal of this study was to determine whether exercise improves insulin sensitivity in insulin-resistant subjects by downregulating proinflammatory signaling in immune cells.Methods. Seventeen lean, 8 obese nondiabetic, and 11 obese type 2 diabetic individuals underwent an aerobic exercise program for 15 days and an insulin clamp before and after exercise. Peripheral mononuclear cells (PMNC) were obtaine

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Keizer-Garritsen, Jenneke J., Connie Brouwer, Lambert H. J. Lambooy, et al. "Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 1 (2003): 86–93. http://dx.doi.org/10.1258/000456303321016222.

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Background: Monitoring 6-thiopurine S-methyltransferase (TPMT; EC 2.1.1.67) activity is especially important when patients are treated with 6-thiopurine drugs, since severe bone marrow toxicity may be induced if patients have deficient TPMT activity. Methods: We have developed a method based on high-performance liquid chromatography (HPLC) for the measurement of TPMT activity in various cell types: erythrocytes (RBC), human peripheral blood mononuclear cells (pMNC) and human malignant lymphoblasts (Molt-F4). The enzymatic activity is measured by the amount of 6-methylmercaptopurine formed, usi

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Wood, Paul, Jayesh Desai, Kelly Waldeck, et al. "ATRT-17. A phase II study of continuous low dose panobinostat in paediatric patients with malignant rhabdoid tumours and atypical teratoid rhabdoid tumours." Neuro-Oncology 24, Supplement_1 (2022): i6—i7. http://dx.doi.org/10.1093/neuonc/noac079.016.

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Abstract BACKGROUND: Panobinostat treatment has been shown to terminally differentiate malignant rhabdoid tumours (MRT) and atypical teratoid rhabdoid tumours (ATRT) in pre-clinical models. We report results of the open label, phase II study of oral panobinostat in patients with newly diagnosed or relapsed MRT/ATRT. AIMS: To assess the anti-tumour activity of low dose, continuous oral panobinostat as well as its associated toxicities. To assess the biological activity of low dose panobinostat by measuring histone H4 acetylation status in peripheral mononuclear cells (PMNC), and differentiation

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Wood, Paul, Jayesh Desai, Kelly Waldeck, et al. "ATRT-08. A PHASE II STUDY OF CONTINUOUS LOW DOSE PANOBINOSTAT IN PAEDIATRIC PATIENTS WITH MALIGNANT RHABDOID TUMORS/ATYPICAL TERATOID RHABDOID TUMORS." Neuro-Oncology 22, Supplement_3 (2020): iii277. http://dx.doi.org/10.1093/neuonc/noaa222.008.

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Abstract BACKGROUND Panobinostat treatment has been shown to terminally differentiate malignant rhabdoid tumor (MRT)/atypical teratoid rhabdoid tumors (ATRT) in pre-clinical models. This is an open label, phase II study of panobinostat in patients with newly diagnosed or relapsed MRT/ATRT. AIMS: To assess the anti-tumor activity of low dose, continuous panobinostat, its associated toxicities, the biological activity of low dose panobinostat by measuring histone acetylation status in peripheral mononuclear cells (PMNC), and markers of differentiation in fresh tumor tissue specimens. METHODS Fol

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Diaz, Daphne, Gregory N. Prado, Patricia Neuman, et al. "Aldosterone Stimulates a Degranulation Response in Human Neutrophils: Role of Protein Disulfide Isomerase." Blood 120, no. 21 (2012): 1034. http://dx.doi.org/10.1182/blood.v120.21.1034.1034.

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Abstract Abstract 1034 There is growing evidence for an important role of aldosterone (ALDO) in inflammatory responses in addition to its well-described effects on sodium homeostasis via activation of the mineralocorticoid receptor (MR). We studied the effects of ALDO on activation of ex vivo human polymorphonuclear leukocytes (PMNC). We isolated untouched circulating human PMNC by immunomagnetic isolation following density gradient sedimentation with PolymorphPrep from otherwise healthy subjects. Flow cytometric analyses showed greater than 97% of PMNC were positive for myeloid-neutrophil mar

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Ramos-Rivera, Arelys, Alicia Rivera, Enrique D. Machado-Fiallo, Josue A. Benabe-Carlo, Gregory N. Prado та Jose R. Romero. "Aldosterone Stimulates Neutrophils Leading To Increased β-Glucuronidase, Protein Disulfide Isomerase and Myeloperoxidase Secretion". Blood 122, № 21 (2013): 2271. http://dx.doi.org/10.1182/blood.v122.21.2271.2271.

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Abstract Aldosterone (ALDO) has been shown to play an important role in inflammatory responses in addition to its well described effects on sodium homeostasis via activation of the mineralocorticoid receptor (MR). However, its effects on polymorphonuclear leukocytes (PMNC) are not well described. We isolated untouched circulating human PMNC by immunomagnetic isolation following density gradient sedimentation with PolymorphPrep from otherwise healthy subjects. Flow cytometric analyses showed greater than 97% of PMNC were positive for the myeloid-neutrophil markers, CD45, CD16 and CD66b. We show

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Al Mutoki, Sabah Mohammed Mlkat, Baydaa Abul Hassan Khalaf Al Ghzawi, Samir M. Abdul Amohsin, and Emad Abbas Jaffar Al-Mulla. "Raman shift of silicon rubber-nano titania PMNC." Epitoanyag - Journal of Silicate Based and Composite Materials 69, no. 1 (2017): 20–23. http://dx.doi.org/10.14382/epitoanyag-jsbcm.2017.4.

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Bahramnia, Hamed, Hamidreza Mohammadian Semnani, Ali Habibolahzadeh, and Hassan Abdoos. "Epoxy/polyurethane nanocomposite coatings for anti-erosion/wear applications: A review." Journal of Composite Materials 54, no. 22 (2020): 3189–203. http://dx.doi.org/10.1177/0021998320908299.

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Offshore pipelines are vulnerable against erosion/wear deterioration mechanisms that can be controlled through the use of proper surface coatings, such as polymer matrix nano-composite (PMNC) coatings that are well-known for their ease of production, availability and applicability. Epoxy, as a versatile rigid and brittle resin and polyurethane with proper chemical/mechanical properties, are potential candidates to make the matrix of these composites. A combination of these polymers can also enhance the mechanical behaviors, glass transition temperature and flexibility. In addition, the desired

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Schmidt-Lucke, Caroline, Felicitas Escher, Sophie Van Linthout, et al. "Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy." Mediators of Inflammation 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/308185.

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Introduction. Mesenchymal stromal cells (MSC) have immunomodulatory features. The aim of this study was to investigate the migration and homing potential of endogenous circulating MSC in virus negative inflammatory cardiomyopathy (CMi).Methods. In 29 patients withn=23or withoutn=6CMi undergoing endomyocardial biopsies (EMB), transcardiac gradients (TCGs) of circulating MSC were measured by flow cytometry from blood simultaneously sampled from aorta and coronary sinus. The presence of MSC in EMB, cardiac inflammation, and SDF-1αmRNA expression were detected via immunohistochemistry and real-tim

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Marković, Maja D., Sanja I. Šešlija, Vesna V. Panić, and Pavle M. Spasojević. "Dual responsive hybrid hydrogels for controlled release of local anesthetic." Procesna tehnika 33, no. 2 (2022): 18. http://dx.doi.org/10.24094/ptc.021.33.2.18.

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Inteligent hydrogels, such as pH sensitive hydrogels based on poly(methacrylic acid) (PMAA) are widely used for targeted drug delivery. Still, PMAA lack of good mechanical properties often limits its application. In order to overcome this limitation nanocellulose (NC) was extracted from wood waste material and then added to PMAA because NC is biocompatible, non-toxic and has excellent mechanical properties. Further, carboxymethyl cellulose (CMC) (cellulose derivate widely used for controlled release of drugs) was added. CMC can stabilize magnetite nanoparticles (MN) which is then also added. M

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Archuadze, Shorena, Elena Mikhailova, Elena Parovichnikova, Sergei Kulikov, and Valeri Savchenko. "IL-12 Producing Capacity of Cultivated Dendritic Cells of Aplastic Anemia Patients during Disease Manifestation and Immunosuppressive Treatment." Blood 110, no. 11 (2007): 4084. http://dx.doi.org/10.1182/blood.v110.11.4084.4084.

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Abstract Dendritic cells (DCs) play principal role in the induction of antigen-specific T-cell immune response and in the development of antigen-specific self-tolerance. Moreover, they promote either Th1 or Th2 polarization of naive lymphocytes by production of immunoregulatory cytokines (IL-12 and IL-10). AA is characterized by increased Th1/Th2 ratio and by Th1 mediated antigen-specific suppression of hematopoiesis. DCs might be responsible for the activation of T-clone in AA patients. However, functional characteristics such as IL-12 production by DC in AA patients have not been studies yet

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Al-Mutoki, Sabah Mohammed Mlkat, Ahmad Ghanim Wadday, Ali Abdulabbas Abdullah, Baydaa Abdul-Hassan Khalaf Al-Ghzawi, and Emad A. Jaffar Al-Mulla. "Effect of nanoTiO 2 dopant on electrical properties of SR8100/nanoTiO 2 PMNC." Results in Physics 6 (2016): 551–53. http://dx.doi.org/10.1016/j.rinp.2015.12.006.

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Eskinazi, Daniel P., John J. Perna, Abby G. Ershow, and R. Clifford Mihail. "Depressed PMNC Blastogenic Response in Patients with Cancer of the Head and Neck." Laryngoscope 99, no. 2 (1989): 151???157. http://dx.doi.org/10.1288/00005537-198902000-00006.

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Etienne, M. C., J. L. Lagrange, O. Dassonville, et al. "Population study of dihydropyrimidine dehydrogenase in cancer patients." Journal of Clinical Oncology 12, no. 11 (1994): 2248–53. http://dx.doi.org/10.1200/jco.1994.12.11.2248.

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PURPOSE We conducted a prospective study on a large set of cancer patients in an attempt to evaluate the incidence of complete or partial dihydropyrimidine dehydrogenase (DPD) deficiency as found in peripheral mononuclear cells (PMNC). PATIENTS AND METHODS One hundred eighty-five unselected consecutive cancer patients were included. The population consisted of 152 men (mean age, 62.1 years; range, 35 to 90) and 33 women (mean age, 59.2 years; range, 36 to 77). Sixty-eight were head and neck patients treated by a 5-day continuous infusion of fluorouracil (FU; starting dose, 1 g/m2/d, with dose

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Wang, Shuai, Zewei Sun, Wenting Zhao та ін. "CD97/ADGRE5 Inhibits LPS Induced NF-κB Activation through PPAR-γUpregulation in Macrophages". Mediators of Inflammation 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1605948.

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CD97/ADGRE5 protein is predominantly expressed on leukocytes and belongs to the EGF-TM7 receptors family. It mediates granulocytes accumulation in the inflammatory tissues and is involved in firm adhesion of PMNC on activated endothelial cells. There have not been any studies exploring the role of CD97 in LPS induced NF-κB activation in macrophages. Therefore, we first measured the CD97 expression in LPS treated human primary macrophages and subsequently analyzed the levels of inflammatory factor TNF-αand transcription factor NF-κB in these macrophages that have been manipulated with either CD

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Freeh, Daniel M., and Mehmet Sarikaya. "Polymorphic Transition in Biogenic Calcium Carbonate: Nacre/Prismatic Interface in Abalone Shell." Microscopy and Microanalysis 3, S2 (1997): 753–54. http://dx.doi.org/10.1017/s1431927600010655.

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The research in biological hard tissues offers lessons for biomimetic (structure and processing) strategies, such as for the synthesis of hierarchical architectures tailored for specific engineering applications. These biocomposites, i.e., biogenic materials in which the major phase is an inorganic component associated with macromolecules (proteins and polysaccharides), include bones, dentin, sea-urchin skeletal units, bacterial and algal particles and molluscan shells. Here, a summary is given from a recent TEM study of the interfacial region of nacreous and prismatic sections of red abalone

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Gentile, D., A. Patel, and D. Skoner. "Association between Second-Hand Smoke Exposure (SSE) and enhanced peripheral blood mononuclear cell (PMNC) IL-13 production during infancy." Journal of Allergy and Clinical Immunology 115, no. 2 (2005): S116. http://dx.doi.org/10.1016/j.jaci.2004.12.475.

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ElKarim, Rihab, Carl Granert, Lars Lindquist, Hans Link, and Moiz Bakhiet. "Levels of Gamma Interferon and Interleukin-4 Are Inversely Related to the Levels of Their Corresponding Autoantibodies in Patients with Lower Respiratory Tract Infection." Infection and Immunity 67, no. 6 (1999): 3051–54. http://dx.doi.org/10.1128/iai.67.6.3051-3054.1999.

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ABSTRACT To study the involvement of cytokines and their corresponding autoantibodies (Aabs) in inflammatory mechanisms in patients with lower respiratory tract infections, blood samples were taken from patients at the time of admission to the hospital and before treatment. Cell-released capturing enzyme-linked immunosorbent assay was used to measure the levels of gamma interferon (IFN-γ) and interleukin-4 (IL-4) produced spontaneously by peripheral mononuclear cells (PMNC). ELISA was used to measure Aabs to these cytokines in sera. The levels of both cytokines were inversely related to the le

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Lima, Péricles Souza, and Fernando de Morais. "COMPARTIMENTAÇÃO GEOMORFOLÓGICA DO EXOCARSTE DE NATIVIDADE E CHAPADA DA NATIVIDADE – TO." Caminhos de Geografia 24, no. 91 (2023): 346–65. http://dx.doi.org/10.14393/rcg249161623.

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O sudeste do Tocantins caracteriza-se, dentre outros aspectos geográficos, pela presença de um carste bem desenvolvido, o que motivou a realização da compartimentação geomorfológica do relevo cárstico localizado nos municípios de Natividade e Chapada da Natividade. Neste sentido, este artigo objetivou tecer considerações sobre a influência dos fatores endógenos e exógenos na configuração da paisagem, enquanto eram definidas cada porção do relevo. Para tanto, com o auxílio das imagens dos satélites ALOS/Palsar, Sentinel 2A e da carta topográfica (SC.23-Y-C-IV), foram feitos mapas da rede de dre

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Tiwari, U. P., B. Turano, and R. Jha. "Nutritional characteristics and in vitro digestibility by near-infrared spectroscopy of local and hybrid napiergrass varieties grown in rain-fed and irrigated conditions." Animal Production Science 54, no. 10 (2014): 1775. http://dx.doi.org/10.1071/an14289.

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Napiergrass can produce large amounts of biomass and its nutritive value has a significant effect on its effectiveness for animal production. However, temperature and drought stress limit its productivity. Drought-tolerant pearl millet × napiergrass hybrid (PMN) varieties were developed and produce high biomass yields. The nutritional content and digestibility of PMN is not well known, which limits its use in animal feeding. It was hypothesised that PMN hybrids are more drought tolerant and have higher nutritive value than napiergrass varieties. Four napiergrass varieties (Bana grass, Mott, MB

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Iqbal, Shazia Sarwat, Muhammad Jamaluddin, and Maria Saleem Mudassir. "Transformation of PMDC to PMC." ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE 25, no. 3 (2020): 122–23. http://dx.doi.org/10.58397/ashkmdc.v25i3.362.

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In Pakistan, medical professions are controlled and regulated by a body for proper function. Initially, it was Pakistan Medical and Dental Council (PMDC) but now it has become Pakistan Medical Commission (PMC). The Pakistan Medical Council Ordinance 1962 established the present-day Pakistan Medical and Dental Council as a statutory body in 1962 and all provincial councils were dissolved then. Three amendments were passed after the establishment of PMDC known as (Amendment)Act in 1973, 1999, and 20121. Now the PMC was established on 24th September 2020 for the regulation and control of the medi

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Ishikawa, K., S. Sadahiro, T. Suzuki, H. Makuuchi, and C. Murayama. "562 Dihydropyrimidine dehydrogenase (DPD) activity in peripheral mononuclear cells (PMNC-DPD) during long-term treatment with oral uracll/tegafur (UFT) as postoperative adjuvant chemotherapy for colorectal cancer (CRC)." European Journal of Cancer Supplements 1, no. 5 (2003): S170. http://dx.doi.org/10.1016/s1359-6349(03)90594-5.

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Tuan, Dang Anh, Ngo Vo Thien Nhan, Pham Vu Nhat Uyen, Bui Thi Hong Loan, Jan Masak, and Tran Ngoc Dang. "Inhibitory effects of trans-cinnamaldehyde on candida spp. Biofilm and planktonic form compared to nystatin: A comparative analysis." Tạp chí Nghiên cứu Y học 173, no. 12E13 (2023): 167–75. http://dx.doi.org/10.52852/tcncyh.v173i12e13.2178.

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Trans-Cinnamaldehyde, an α, β-unsaturated aromatic aldehyde, was a derivative of Cinnamonnum obtusifolium - Lauraceae; its bioavailability allows it to be used in the treatment of fungal infections as Candida species causing opportunistic fungal infections are common today. Antibiotic resistance in fungi is often due to their ability to form biofilm. Therefore, new substances with antibiofilm were being investigated as alternative treatment. Representatives of Candida spp. were used to determine the MIC, MBIC50, MBIC80, MBIC100, and MFC of trans-Cinnamaldehyde compared to Nystatin which is use

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Abdelsalam, Mostafa, Mona M. Tawfik, Alaa Habib, et al. "Occult hepatitis C virus infection among Egyptian hemodialysis patients and its potential effect on anemia management." Egyptian Journal of Internal Medicine 31, no. 4 (2019): 783–89. http://dx.doi.org/10.4103/ejim.ejim_94_19.

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Abstract Background Hepatitis C virus (HCV) infection is still a main health problem in hemodialysis (HD) patients. The prevalence of occult hepatitis C infection (OCI) in HD patients may be underestimated, and its possible influence on anemia management has not been studied. We aimed to determine the existence of OCI in Egyptian HD patients as well as its possible effect on anemia management. Patients and methods This cross-sectional multicenter study included 98 HCV-negative HD patients (negative for both anti-HCV antibody and HCV-RNA), 43 anti-HCV-positive HD patients, and 10 volunteer peop

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Korbling, M., YO Huh, A. Durett, et al. "Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy- 1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease." Blood 86, no. 7 (1995): 2842–48. http://dx.doi.org/10.1182/blood.v86.7.2842.2842.

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Abstract Apheresis-derived hematopoietic progenitor cells have recently been used for allogeneic transplantation. Forty-one normal donors were studied to assess the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) (12 micrograms/kg/d) on the peripheralization of hematopoietic progenitor cells and lymphoid subsets. The white blood cell, polymorphonuclear cell (PMNC), and lymphocyte concentrations at the peak of rhG-CSF effect in the donor's peripheral blood (PB) exceeded baseline by 6.4-, 8.0-, and 2.2-fold, respectively. Corresponding concentrations of PB CD34+ cell

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Korbling, M., YO Huh, A. Durett, et al. "Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy- 1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease." Blood 86, no. 7 (1995): 2842–48. http://dx.doi.org/10.1182/blood.v86.7.2842.bloodjournal8672842.

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Apheresis-derived hematopoietic progenitor cells have recently been used for allogeneic transplantation. Forty-one normal donors were studied to assess the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) (12 micrograms/kg/d) on the peripheralization of hematopoietic progenitor cells and lymphoid subsets. The white blood cell, polymorphonuclear cell (PMNC), and lymphocyte concentrations at the peak of rhG-CSF effect in the donor's peripheral blood (PB) exceeded baseline by 6.4-, 8.0-, and 2.2-fold, respectively. Corresponding concentrations of PB CD34+ cells and pri

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Slavutskaya, M., I. Lebedeva, M. Omelchenko, E. Abdullina, and S. Karelin. "EEG correlates of impaired anticipation processes in the early stages of schizophrenia." European Psychiatry 65, S1 (2022): S315—S316. http://dx.doi.org/10.1192/j.eurpsy.2022.804.

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Introduction An impairment of anticipation processes is considered as a common deficiency in schizophrenia (Kveraga et al., 2007), however its neural mechanisms remain poorly understood. Objectives The aim of the study was to analyze CNV-like slow negative waves during the pre-target stimuli waiting period in patients with the first episode of the disease. Methods 32-channels EEGs during “Go / No go delay” saccadic paradigm have been recorded in 16 young male patients with illness duration less than 2 years and 18 age and sex matched healthy subjects. The delay period between fixation and targ

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S. Kashan, Jenan,, and Saad M. Ali. "3D Model of Bone Scaffolds Based on the Mechanical Behaviour for a Hybrid Nano Bio-composites." journal of Mechanical Engineering 17, no. 2 (2020): 45–67. http://dx.doi.org/10.24191/jmeche.v17i2.15300.

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Ceramic/polymer Nano composites in the view of possessing design uniqueness and property combinations have gained a great attention and reported to be the materials of the 21st century that are not found in conventional composites. In the present work, an attempt has been made to study, develop and improve the bio-mechanic for a designed and fabricated Ceramic/polymer bio-composite for a human natural bone repair and replacement in the case of complex fracture and bone diseases by adding the Nano fillers ceramic particles to the Polymer Matrix Nano composites (PMNC) for fabricated a hybrid Tit

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Lipton, Brian P., Abraham P. Bautista, Joseph B. Delcarpio, and Kathleen H. McDonough. "Effects of endotoxin on neutrophil-mediated I/R injury in isolated perfused rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 2 (2001): H802—H811. http://dx.doi.org/10.1152/ajpheart.2001.280.2.h802.

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With the use of a syngeneic model, we demonstrate that rat polymorphonuclear neutrophils (PMNs) exacerbate ischemia-reperfusion injury in the isolated rat heart. However, PMNs (19 × 106cells) from lipopolysaccharide (LPS)-treated rats (LPS-PMNs; 100 mg/kg administered 7 h before exsanguination) induce less reperfusion injury in the isolated heart. Average recovery of left ventricular developed pressure after 20 min of ischemia and 60 min of reperfusion was 51 ± 4% in hearts receiving PMNs from saline-treated control rats (saline-PMNs) versus 78 ± 2% in hearts receiving LPS-PMNs. Ischemic heart

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Hannon, Connor, Patrick L. Quinn, Stephanie Iacono, et al. "The impact of a pancreatic cancer multi-disciplinary clinic on patient-centric outcomes." Journal of Clinical Oncology 42, no. 3_suppl (2024): 641. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.641.

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641 Background: A one-day multi-disciplinary clinic allows for a comprehensive evaluation of patients in a single-visit format. This study aims to evaluate the impact of a one-day pancreatic cancer multi-disciplinary clinic (PMDC) on patient-centric outcomes. Methods: Patients with pancreatic cancer who were seen at The Ohio State University PMDC from January 2021 to March 2023 were identified. Patient-centric outcomes were evaluated including time from diagnosis to first evaluation and treatment, number of supportive care referrals completed, and number of physical trips to the medical center

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Collins, Thomas, Daniel Hickman, Danuksha K. Amarasena, and Anand Pillai. "Pedal medial artery calcification score as a prognostic marker for the success of surgical intervention in diabetic foot disease." Practical Diabetes 41, no. 4 (2024): 22–26. http://dx.doi.org/10.1002/pdi.2519.

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AbstractAims: This study aimed to investigate for a causal link between severity of pedal medial artery calcification (pMAC) and the success of surgical interventions in the treatment of diabetic foot ulceration (DFU). Our secondary aim was to compare pMAC and traditional vascular studies used in the preoperative assessment for surgical interventions in DFU.Methods: A single‐centre, retrospective observational study was performed for patients undergoing debridement or amputation for DFU between October 2019 and March 2023. Patient pMAC scores were calculated using the Ferraresi classification.

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Lawrence, MB, LV McIntire, and SG Eskin. "Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion." Blood 70, no. 5 (1987): 1284–90. http://dx.doi.org/10.1182/blood.v70.5.1284.1284.

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Abstract The effect of flow on the adhesion of polymorphonuclear leukocytes (PMNL) to vascular endothelium was investigated using a parallel plate chamber with a well-defined flow field. Washed PMNL were perfused over a monolayer of primary human umbilical vein endothelial cells (HUVEC) pretreated with formyl-methionyl-leucyl-phenylalanine (FMLP, 1 X 10(-7) mol/L) for five minutes. In other experiments HUVEC were pretreated with interleukin 1 (IL1,2 U/mL) for four hours. PMNL adhesion to stimulated and control HUVEC was measured over a physiologic range of wall shear stresses. PMNL adhesion to

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Lawrence, MB, LV McIntire, and SG Eskin. "Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion." Blood 70, no. 5 (1987): 1284–90. http://dx.doi.org/10.1182/blood.v70.5.1284.bloodjournal7051284.

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The effect of flow on the adhesion of polymorphonuclear leukocytes (PMNL) to vascular endothelium was investigated using a parallel plate chamber with a well-defined flow field. Washed PMNL were perfused over a monolayer of primary human umbilical vein endothelial cells (HUVEC) pretreated with formyl-methionyl-leucyl-phenylalanine (FMLP, 1 X 10(-7) mol/L) for five minutes. In other experiments HUVEC were pretreated with interleukin 1 (IL1,2 U/mL) for four hours. PMNL adhesion to stimulated and control HUVEC was measured over a physiologic range of wall shear stresses. PMNL adhesion to nylon-co

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Minamino, T., M. Kitakaze, K. Node, et al. "Adenosine inhibits leukocyte-induced vasoconstriction." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 6 (1996): H2622—H2628. http://dx.doi.org/10.1152/ajpheart.1996.271.6.h2622.

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Polymorphonuclear leukocytes (PMNs) can induce endothelium-dependent constriction of vascular rings. Because adenosine inhibits the function of PMNs, we examined the effects of adenosine on the PMN-induced coronary vasoconstriction. We measured changes in the isometric tension of isolated rings of canine coronary arteries suspended in an organ chamber filled with Krebs-Henseleit solution after the addition of autologous PMNs. N-formyl-L-methionyl-leucyl-phenylalanine (FMLP)-stimulated PMNs increased the tension of the coronary artery with the endothelium in a concentration-dependent manner. Tr

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Bass, D. A., P. Olbrantz, P. Szejda, M. C. Seeds, and C. E. McCall. "Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection." Journal of Immunology 136, no. 3 (1986): 860–66. http://dx.doi.org/10.4049/jimmunol.136.3.860.

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Abstract Stimulated human polymorphonuclear leukocytes (PMNL) have a marked increase in oxidative metabolism, producing reduced oxygen species (e.g., H2O2) that mediate bacterial killing. Previously, quantitation of metabolic responses of PMNL from patients with acute infections employed assays that measure mean activity of the entire PMNL population; such studies reported a modest and highly variable increase in oxidative metabolic responses of such "toxic" PMNL compared with normal cells. To assess metabolic capability of PMNL from 51 patients with acute bacterial infection, we employed a qu

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Patel, Roshal R., Rose Parisi, Vivek Verma, et al. "Association between Prior Malignancy Exclusion Criteria and Age Disparities in Cancer Clinical Trials." Cancers 14, no. 4 (2022): 1048. http://dx.doi.org/10.3390/cancers14041048.

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Prior malignancy exclusion criteria (PMEC) are often utilized in cancer clinical trials; however, the incidence of PMEC and the association of PMEC with trial participant age disparities remain poorly understood. This study aimed to identify age disparities in oncologic randomized clinical trials as a result of PMEC. Using a comprehensive collection of modern phase III cancer clinical trials obtained via ClinicalTrials.gov, we assessed the incidence and covariates associated with trials excluding patients with prior cancers within 5+ years from registration (PMEC-5). Using the National Cancer

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Ren, Yunjia, Li Hua, Xiuping Meng, et al. "Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced byE. coli." Mediators of Inflammation 2016 (2016): 1–17. http://dx.doi.org/10.1155/2016/3296307.

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IL-17 is a proinflammatory cytokine produced by various immune cells. Polymorphonuclear neutrophils (PMNs) are the first line of defense in bacterial infection and express surface Toll-like receptor 9 (sTLR9). To study the relationship of sTLR9 and IL-17 in PMNs during bacterial infection, we infected mice withE. coliintraperitoneally to establish a septic peritonitis model for studying the PMNs response in peritoneal cavity. We found that PMNs and some of “giant cells” were massively accumulated in the peritoneal cavity of mice with fatal septic peritonitis induced byE. coli. Kinetically, the

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van Spriel, Annemiek B., Jeanette H. W. Leusen, Marjolein van Egmond, et al. "Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated neutrophil cytotoxicity and immunologic synapse formation." Blood 97, no. 8 (2001): 2478–86. http://dx.doi.org/10.1182/blood.v97.8.2478.

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Abstract Receptors for human immunoglobulin (Ig)G and IgA initiate potent cytolysis of antibody (Ab)-coated targets by polymorphonuclear leukocytes (PMNs). Mac-1 (complement receptor type 3, CD11b/CD18) has previously been implicated in receptor cooperation with Fc receptors (FcRs). The role of Mac-1 in FcR-mediated lysis of tumor cells was characterized by studying normal human PMNs, Mac-1–deficient mouse PMNs, and mouse PMNs transgenic for human FcR. All PMNs efficiently phagocytosed Ab-coated particles. However, antibody-dependent cellular cytotoxicity (ADCC) was abrogated in Mac-1−/− PMNs

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Lawrence, MB, CW Smith, SG Eskin, and LV McIntire. "Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium." Blood 75, no. 1 (1990): 227–37. http://dx.doi.org/10.1182/blood.v75.1.227.227.

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Abstract The CD11/CD18 family of glycoproteins has been identified as a mediator of a number of adhesive interactions crucial to inflammatory responses. Using a monoclonal antibody (MoAb) against CD18 (TS1/18), the role of these molecules in polymorphonuclear neutrophil (PMNL) adhesion to cultured primary human umbilical vein endothelial cells (HUVEC) was examined under venous flow conditions. Incubation of PMNL with TS1/18 (anti-CD18) did not inhibit PMNL adhesion to interleukin-1 (IL-1)- treated HUVEC at 2.0 dynes/cm2 (TS1/18-treated 305 +/- 58 PMNL/mm2 v 334 +/- 63 PMNL/mm2 on control). Fur

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Lawrence, MB, CW Smith, SG Eskin, and LV McIntire. "Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium." Blood 75, no. 1 (1990): 227–37. http://dx.doi.org/10.1182/blood.v75.1.227.bloodjournal751227.

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The CD11/CD18 family of glycoproteins has been identified as a mediator of a number of adhesive interactions crucial to inflammatory responses. Using a monoclonal antibody (MoAb) against CD18 (TS1/18), the role of these molecules in polymorphonuclear neutrophil (PMNL) adhesion to cultured primary human umbilical vein endothelial cells (HUVEC) was examined under venous flow conditions. Incubation of PMNL with TS1/18 (anti-CD18) did not inhibit PMNL adhesion to interleukin-1 (IL-1)- treated HUVEC at 2.0 dynes/cm2 (TS1/18-treated 305 +/- 58 PMNL/mm2 v 334 +/- 63 PMNL/mm2 on control). Furthermore,

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Sykulev, Yuri, Nadia Anikeeva, and Dimitry Gakamsky. "The role of peptide-MHC ligand density in stimulating T-cell receptor signaling (58.21)." Journal of Immunology 188, no. 1_Supplement (2012): 58.21. http://dx.doi.org/10.4049/jimmunol.188.supp.58.21.

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Abstract Cell surface MHC proteins form clusters on the cell membrane. The MHC density within clusters could affect recognition of noncognate (self) and cognate peptide-MHC (pMHC) ligands and influence the kinetics of TCR-mediate signaling and quality of T cell responses. To evaluate the role of density, orientation and valency of pMHC ligands we utilized different scaffolds to assemble pMHC oligomers modeling MHC clusters. We systematically investigated how these parameters influence the binding of the pMHC oligomers to live CD8+ cytotoxic T lymphocytes (CTL) and the kinetics of TCR-mediated

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Cho, Kyung-Jin, Even Walseng, Satoshi Ishido, and Paul A. Roche. "Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells." Proceedings of the National Academy of Sciences 112, no. 33 (2015): 10449–54. http://dx.doi.org/10.1073/pnas.1507981112.

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MHC class II (MHC-II)-dependent antigen presentation by antigen-presenting cells (APCs) is carefully controlled to achieve specificity of immune responses; the regulated assembly and degradation of antigenic peptide–MHC-II complexes (pMHC-II) is one aspect of such control. In this study, we have examined the role of ubiquitination in regulating pMHC-II biosynthesis, endocytosis, recycling, and turnover in APCs. By using APCs obtained from MHC-II ubiquitination mutant mice, we find that whereas ubiquitination does not affect pMHC-II formation in dendritic cells (DCs), it does promote the subseq

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Cacchillo, David A., and John D. Walters. "Effect of Ciprofloxacin on Killing of Actinobacillus actinomycetemcomitans by Polymorphonuclear Leukocytes." Antimicrobial Agents and Chemotherapy 46, no. 6 (2002): 1980–84. http://dx.doi.org/10.1128/aac.46.6.1980-1984.2002.

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ABSTRACT Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing A. actinomycetemcomitans than control PMNs. Isolated human PMNs were loaded by brief incubation with 0.5 μg of ciprofloxacin/ml. Opsonized bacteria (ATCC 43718) were incubated at 37°C with control and ciprofloxacin-loaded PMNs and in the presence and absence of 0.5 μg of

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Jin, Yutong, Brian Dixon, Lyndon Jones, and Maud Gorbet. "The Differential Reactive Oxygen Species Production of Tear Neutrophils in Response to Various Stimuli In Vitro." International Journal of Molecular Sciences 22, no. 23 (2021): 12899. http://dx.doi.org/10.3390/ijms222312899.

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A large number of polymorphonuclear neutrophils (PMNs) invade the ocular surface during prolonged eye closure (sleep); these leukocytes are commonly referred as tear PMNs. PMNs contribute to homeostasis and possess an arsenal of inflammatory mediators to protect against pathogens and foreign materials. This study examined the ability of tear PMNs to generate reactive oxygen species (ROS), an essential killing mechanism for PMNs which can lead to oxidative stress and imbalance. Cells were collected after sleep from healthy participants using a gentle eye wash. ROS production in stimulated (phor

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