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Journal articles on the topic 'Podophyllin'

Author: Grafiati
Published: 12 December 2022
Last updated: 27 February 2023

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1

Dolezal, James F. "Podophyllum resin and podophyllin." Journal of the American Academy of Dermatology 12, no. 4 (April 1985): 728–30. http://dx.doi.org/10.1016/s0190-9622(85)80174-2.

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2

&NA;. "Podophyllin." Reactions Weekly &NA;, no. 1400 (May 2012): 34. http://dx.doi.org/10.2165/00128415-201214000-00128.

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3

&NA;. "Podophyllin." Reactions Weekly &NA;, no. 407 (June 1992): 10. http://dx.doi.org/10.2165/00128415-199204070-00037.

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&NA;. "Podophyllin." Reactions Weekly &NA;, no. 929 (November 2002): 10. http://dx.doi.org/10.2165/00128415-200209290-00035.

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&NA;. "Podophyllin." Reactions Weekly &NA;, no. 331 (December 1990): 10. http://dx.doi.org/10.2165/00128415-199003310-00053.

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6

&NA;. "Podophyllin." Reactions Weekly &NA;, no. 509 (July 1994): 10. http://dx.doi.org/10.2165/00128415-199405090-00050.

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7

&NA;. "Podophyllin." Reactions Weekly &NA;, no. 1350 (May 2011): 38. http://dx.doi.org/10.2165/00128415-201113500-00131.

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8

Miller, Robert A. "Podophyllin." International Journal of Dermatology 24, no. 1 (January 1985): 491–98. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05535.x.

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9

Miller, Robert A. "Podophyllin." International Journal of Dermatology 24, no. 8 (October 1985): 491–98. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05827.x.

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10

&NA;. "Podophyllin poisoning." Reactions Weekly &NA;, no. 325 (November 1990): 11. http://dx.doi.org/10.2165/00128415-199003250-00052.

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11

Lassus, Allan. "PODOPHYLLIN/PODOPHYLLOTOXIN." Lancet 330, no. 8572 (December 1987): 1395. http://dx.doi.org/10.1016/s0140-6736(87)91283-9.

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12

Altaha, Lama. "Evaluation of podophyllin and Trichloroacetic acid for the treatment of genital warts in Iraqi female patients." AL-Kindy College Medical Journal 18, no. 1 (May 5, 2022): 65–67. http://dx.doi.org/10.47723/kcmj.v18i1.276.

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Background: human paillomavirus infections (genital warts) are the most frequent sexually transmitted viral infections. a wide range of treatment options is available with different efficacy. Objective: To evaluate the efficacy of podophyllin, trichloracetic acid (TCA) in the treatment of genital warts and side effects of them. Subjects and methods: a total of sixty patients with genital warts were randomly selected, 30 in each group, in the Department of Dermatology, medical city for a Duration of 11 months from January 2009 to December 2009 treated with 35 % podophyllin in the tincture of benzoin or 50% TCA) .Forty-eight patients were followed up for three months. Results: warts cleared in 63% and 70% of the patients after treatment with podophyllin and TCA respectively within 3 months. Soreness happened in 6 patients with podophyllin and in 9 patients with TCA. small ulcers happened in 1 patient by podophyllin and 2 patients with TCA. pain was in 5 patients treated by podophyllin and in 6 patients treated by TCA. erythema was noticed in 10 patients treated by podophyllin and in 11 patients treated by TCA. Conclusion: there was a higher clearance rate with TCA and earlier response. The occurrence of adverse reactions is little more with TCA
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13

Mohanty, K. C. "The Cost Effectiveness of Treatment of Genital Warts with Podophyllotoxin." International Journal of STD & AIDS 5, no. 4 (July 1994): 253–56. http://dx.doi.org/10.1177/095646249400500405.

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The cost effectiveness of 25% podophyllin resin and 0.5% podophyllotoxin solution in the treatment of genital warts in Genitourinary Medicine Clinic attenders was studied. Although the average treatment cost for a course of podophyllotoxin was more than that for podophyllin resin (£20.75 v. £14.95 respectively) the overall cure rate with podophyllotoxin was 66% as opposed to 34.6% with podophyllin. When the costing of secondary treatment options was considered the cost per patient cured of warts with podophyllin resin was £27.15 compared with £25.73 for podophyllotoxin solution (not significant).
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14

Oliveira, Acary Souza Bulle, Leandro Cortoni Calia, Beatriz Hitomi Kiyomoto, Eliane Focaccia Póvoa, Beny Schmidt, and Alberto Alain Gabbai. "Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case." Arquivos de Neuro-Psiquiatria 54, no. 2 (June 1996): 288–92. http://dx.doi.org/10.1590/s0004-282x1996000200017.

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A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity.
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15

Hellberg, Dan, Tove Svarrer, Staffan Nilsson, and Jack Valentin. "Self-Treatment of Female External Genital Warts with 0.5% Podophyllotoxin Cream (Condyline®) vs Weekly Applications of 20% Podophyllin Solution." International Journal of STD & AIDS 6, no. 4 (July 1995): 257–61. http://dx.doi.org/10.1177/095646249500600407.

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Summary: Sixty women with genital warts were randomly allocated to treatment with either weekly application of 20% podophyllin solution or self-treatment with 0.5% podophyllotoxin cream twice daily for three days in weekly intervals. After a maximum of 4 treatment cycles a final assessment was carried out after 3 months. Primary clearance after termination of treatment was 82% for podophyllotoxin and 59% for podophyllin solution. After excluding relapses at the 3-month follow-up, final clearance for podophyllotoxin (71%) was significantly better ( P < 0.05) than that for podophyllin solution (48%). The total frequency of warts eradicated was 94% with podophyllotoxin and 74% with podophyllin solution ( P < 0.001). Local adverse effects were generally mild or moderate. Podophyllotoxin cream provides a mode of easy application for women with external genital warts and had in this study a significantly better effect than podophyllin solution.
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16

Jantaravinid, Jiraporn, Sukhum Jiamton, Chatchawan Srisawat, Bhoom Suktitipat, and Napatara Tirawanchai. "Expression Pattern of Genes in Condyloma Acuminata Treated with Clinacanthus nutans Lindau Cream versus Podophyllin." Evidence-Based Complementary and Alternative Medicine 2021 (September 17, 2021): 1–9. http://dx.doi.org/10.1155/2021/5579520.

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Clinacanthus nutans Lindua (C. nutans), a strong antiviral traditional medicine, can be used to treat condyloma acuminata (CA) caused by the human papillomavirus (HPV). However, its molecular mechanism for CA elimination is unknown. Herein, we conducted a randomized clinical trial to evaluate the effectiveness of C. nutans and its molecular mechanism compared with podophyllin, the gold standard treatment. Using a randomized block design, six patients were treated with C. nutans and podophyllin for four weeks. Efficacy of drugs was assessed by size reduction of the warts and HPV viral load quantification using droplet digital PCR. The gene expression profiling of CA was analyzed using NanoString Technology. After the podophyllin and C. nutans treatments, CA lesion sizes were reduced to 97.0% and 84.4% clearance, and the HPV viral loads were reduced by 74.0% and 46.6%, respectively. The gene expression pattern of immune profiling showed that 23 genes (i.e., HLA-DPB, CCL3, CXCL2, CXCR2, and OSM) were significantly differentially expressed by podophyllin, whereas 2 genes (IFNL1 and IRF2) were remarkably expressed by C. nutans. In inflammatory profiling, 108 genes (i.e., CXCL2, IL8, and STAT3) were highly expressed by podophyllin, but none of genes were observed to change expression by C. nutans. These results suggested that podophyllin may reduce the HPV infection through a mechanism related to proinflammatory response. In addition, C. nutans was found to suppress the HPV infection through mechanism related to the activation of immune response. This study shows novel therapeutic mechanisms of podophyllin and C. nutans. It is suggested that C. nutans might be used as an alternative treatment for CA treatment.
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17

Holdright, Diana R., and Marjan Jahangiri. "Accidental Poisoning with Podophyllin." Human & Experimental Toxicology 9, no. 1 (January 1990): 55–56. http://dx.doi.org/10.1177/096032719000900113.

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Podophyllin is available without prescription and is commonly used in the topical treatment of warts. We describe a case of accidental ingestion of podophyllin, mistaken for cough linctus, and its resultant toxicity.
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18

McClean, Hugo, and Siobhan Shann. "A cross-sectional survey of treatment choices for anogenital warts." International Journal of STD & AIDS 16, no. 3 (March 1, 2005): 212–16. http://dx.doi.org/10.1258/0956462053420130.

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This was a cross-sectional survey that collected data relating to management of anogenital warts (AGW) during a single-patient visit only at genitourinary medicine clinics. Single-agent use of cryotherapy, podophyllotoxin and trichloroacetic acid (TCA) were the most common treatment modalities, accounting for over two-thirds of all modalities used. Podophyllin, alone or in combination with other agents, was used for about 20% of first-line treatments. Podophyllin was included in about 15% of all treatment modalities. Guidelines for the management of AGW continue to recommend the use of podophyllin, but this may need to be modified in the light of recent publications. Podophyllin, TCA, podophyllotoxin or combinations of these agents are commonly used to treat keratinized warts. About 11% of all treatments involved a combination of two or more agents.
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19

GRAY, J. "Podophyllin and mutagenesis." Journal of the European Academy of Dermatology and Venereology 11 (September 1998): S39. http://dx.doi.org/10.1016/s0926-9959(98)94685-2.

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20

Bargman, Howard. "Podophyllin and Pregnancy." International Journal of Dermatology 32, no. 9 (September 1993): 691. http://dx.doi.org/10.1111/j.1365-4362.1993.tb04033.x.

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21

Ling, Mark. "Podophyllin and Pregnancy." International Journal of Dermatology 32, no. 9 (September 1993): 691. http://dx.doi.org/10.1111/j.1365-4362.1993.tb04034.x.

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22

Maatouk, Ismaël. "History of Podophyllin." JAMA Dermatology 152, no. 10 (October 1, 2016): 1105. http://dx.doi.org/10.1001/jamadermatol.2015.6301.

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23

Wardropper, Alison, and Paul Woolley. "Treatment of Anogenital Warts in Genitourinary Clinics in England and Wales." International Journal of STD & AIDS 3, no. 6 (November 1992): 439–41. http://dx.doi.org/10.1177/095646249200300609.

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A questionnaire on the treatment of anogenital warts was sent to 150 consultants in genitourinary medicine, 78 (52%) were returned completed. A wide range of treatments were used; podophyllin was the commonest first line treatment of multiple penile (60.3%), perianal (57.7%) and vulval (61.5%) warts. Cryotherapy was a popular choice for intrameatal warts (65.3%), small numbers of vulval warts (33.3%) and as second line therapy for penile (35.9%) and perianal (33.3%) warts. Vaginal warts were treated with podophyllin (39.7%) or cryotherapy (29.5%). Various combinations of podophyllin, trichloroacetic acid and cryotherapy were used (2.6%–24.3%) although there is no evidence this offers benefit over single therapy. Podophyllin is frequently used despite side effects, a poor clearance rate and in vaginal warts, difficult access. Initial therapy with more time-consuming procedures such as cryotherapy or electrocautery may be of benefit to selected patients.
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24

Jiamton, Sukhum, Pattriya Chanyachailert, Yanisorn Nanchaipruek, Nuttagarn Jantanapornchai, Poramin Patthamalai, Pichaya Limphoka, Ya-Nin Nokdhes, and Jiraporn Jantaravinid. "Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata." Evidence-Based Complementary and Alternative Medicine 2022 (June 23, 2022): 1–6. http://dx.doi.org/10.1155/2022/1577716.

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Human papillomavirus (HPV) infection causes condyloma acuminata (CA). Podophyllin is the standard treatment. Clinacanthus nutans Lindau (C. nutans), a medicinal plant, has potent anti-inflammatory and antiviral effects. C. nutans cream is widely used in Thailand to treat the herpes simplex virus. We proposed that C. nutans might also induce CA clearance. There are no studies of C. nutans treatment of CA. This randomized controlled trial at Siriraj Hospital, Thailand, was conducted between January 2018 and December 2019. CA samples were obtained from 10 men with at least two CAs 1 centimeter apart. Each wart was randomized to a 4-week treatment with either C. nutans or podophyllin. The participants were 24 to 72 years old. Most HPV types were low-risk HPVs (HPV 11, HPV 6). Median CA clearance with podophyllin was a 97% CA clearance with podophyllin and 82% with C. nutans. C. nutans may be an alternative treatment for CA.
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25

Usman, N., K. Udayashankar, S. Subramanian, and S. P. Thyagarajan. "Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study." International Journal of STD & AIDS 7, no. 1 (January 1, 1996): 55–56. http://dx.doi.org/10.1258/0956462961917078.

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An autoimplantation technique was adopted in the treatment of 50 cases of anogenital warts and was compared with the conventionally used podophyllin regimen in a matched group of 50 patients. They were assessed with 15 untreated subjects in a control group for the rate of clinical cure after 6 weeks, recurrence after 1 year follow up and for humoral and cell mediated immune responses before and after treatment. In the podophyllin group, 70% of patients were cured after 6 weeks while in autoimplantation, only 44% of patients were cured, and none in the control group had natural remission of warts without any treatment. After 1 year all the cured cases (100%) that completed follow up had recurrence of warts with podophyllin treatment, while none had recurrence of lesions in the autoimplantation group. Results of the humoral and cell mediated immune (CMI) response studies revealed that autoimplantation technique significantly augmented both humoral and CMI responses while there was no significant change in the immune status after podophyllin treatment (P>0.001).
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26

Oriel, J. D. "Podophyllin--the early days." Sexually Transmitted Infections 73, no. 4 (August 1, 1997): 290. http://dx.doi.org/10.1136/sti.73.4.290.

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27

&NA;. "Cantharidin/petrolatum/podophyllin/salicylic acid." Reactions Weekly &NA;, no. 1212 (July 2008): 10. http://dx.doi.org/10.2165/00128415-200812120-00030.

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28

Rothenborg, Hans W. "Podophyllin treatment of anogenital warts." Journal of the European Academy of Dermatology and Venereology 4, no. 2 (July 28, 2006): 188–89. http://dx.doi.org/10.1111/j.1468-3083.1995.tb00327.x.

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29

Maiti, H., and K. R. Haye. "TOPICAL PODOPHYLLIN FOR GENITAL WARTS." Lancet 330, no. 8562 (October 1987): 795–96. http://dx.doi.org/10.1016/s0140-6736(87)92523-2.

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30

Marcus, Jeffrey, and Charles Camisa. "Podophyllin Therapy for Condyloma Acuminatum." International Journal of Dermatology 29, no. 10 (December 1990): 693–98. http://dx.doi.org/10.1111/j.1365-4362.1990.tb03770.x.

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31

Leitner, J., F. Hofbauer, and M. Ackerl. "Vergiftung mit Podophyllin-haltiger Warzentinktur." DMW - Deutsche Medizinische Wochenschrift 127, no. 28/29 (July 2002): 1516–20. http://dx.doi.org/10.1055/s-2002-32755.

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32

Rothenborg, H. "Podophyllin treatment of anogenital warts." Journal of the European Academy of Dermatology and Venereology 4, no. 2 (April 1995): 188–89. http://dx.doi.org/10.1016/0926-9959(95)93812-z.

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33

O'Mahony, S., C. Keohane, J. Jacobs, D. O'Riordain, and M. Whelton. "Neuropathy due to podophyllin intoxication." Journal of Neurology 237, no. 2 (April 1990): 110–12. http://dx.doi.org/10.1007/bf00314673.

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34

BENNETT, RICHARD G., and WILLIAM J. GRIST. "Nasal Papillomas: Successful Treatment With Podophyllin." Southern Medical Journal 78, no. 2 (February 1985): 224–25. http://dx.doi.org/10.1097/00007611-198502000-00036.

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35

Gorin, F., D. Kindall, and M. Seyd. "Dorsal radiculopathy resulting from podophyllin toxicity." Neurology 39, no. 4 (April 1, 1989): 607. http://dx.doi.org/10.1212/wnl.39.4.607.

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36

Reynolds, M., M. Murphy, M. A. Waugh, and C. J. N. Lacey. "An Audit of Treatment of Genital Warts: Opening the Feedback Loop." International Journal of STD & AIDS 4, no. 4 (July 1993): 226–31. http://dx.doi.org/10.1177/095646249300400410.

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An audit of the treatment of patients (100 men and 90 women) presenting with a first episode of anogenital warts to the Genitourinary Medicine Department at Leeds General Infirmary was performed. Treatment of patients was monitored for a period of 6 months from the time of presentation. The management of patients with genital warts lacked a clearly defined strategy and treatment was unselective and poorly monitored. Excluding patients who defaulted, at follow-up 44 (44%) men and 36 (38%) women still had genital warts at 3 months. Of those patients clear of warts at 3 months, the mean time to remission for men and women was 7.1 and 8.3 weeks respectively. Podophyllin 25% in tincture of benzoin was by far the predominant therapeutic modality used. A total of 96 (96%) men and 76 (84%) women received treatment with podophyllin. Both male and female patients had a mean of 5 treatments with podophyllin 25% (range 1–19 and 1–12 respectively). Physical methods of treatment i.e. cryotherapy and electrocautery, were underutilized, both as primary therapies and when topical agents had failed. Patients saw an average of 3 (range 1–7) doctors over the course of their treatment. Patients with warts affecting 2 or more sites, male patients with anal/perianal warts, and female patients with cervical and vaginal warts had higher failure rates from treatment at 3 months. On the basis of these findings, specific treatment protocols for the management of anogenital warts have been devised.
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37

Singh, Ajeet, Ritul Choudhary, and Satyaki Ganguly. "Podophyllin in dermatology: Revisiting a historical drug." Indian Dermatology Online Journal 13, no. 1 (2022): 167. http://dx.doi.org/10.4103/idoj.idoj_225_21.

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38

Kumar, Manish, Arumugasamy Shanmugham, Sivaprakasam Prabha, Bethou Adhisivam, Parameswaran Narayanan, and Niranjan Biswal. "Permanent Neurological Sequelae Following Accidental Podophyllin Ingestion." Journal of Child Neurology 27, no. 2 (September 12, 2011): 209–10. http://dx.doi.org/10.1177/0883073811415682.

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39

Sholohov, Galina, and Edsel Ing. "Topical podophyllin as a cause of keratopathy." Canadian Journal of Ophthalmology 47, no. 6 (December 2012): e47-e48. http://dx.doi.org/10.1016/j.jcjo.2012.04.018.

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40

Givens, Melissa L., and Wilfredo Rivera. "Genital burns from home use of podophyllin." Burns 31, no. 3 (May 2005): 394–95. http://dx.doi.org/10.1016/j.burns.2004.10.020.

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41

Sundharam, J. A. "Is podophyllin safe for use in pregnancy?" Archives of Dermatology 125, no. 7 (July 1, 1989): 1000–1001. http://dx.doi.org/10.1001/archderm.125.7.1000.

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42

Sanchez, Miguel. "Treatment of Oral Hairy Leukoplakia With Podophyllin." Archives of Dermatology 128, no. 12 (December 1, 1992): 1659. http://dx.doi.org/10.1001/archderm.1992.04530010095028.

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43

Sanchez, M. "Treatment of oral hairy leukoplakia with podophyllin." Archives of Dermatology 128, no. 12 (December 1, 1992): 1659. http://dx.doi.org/10.1001/archderm.128.12.1659.

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44

Sundharam, J. A. "Is Podophyllin Safe for Use in Pregnancy?" Archives of Dermatology 125, no. 7 (July 1, 1989): 1000. http://dx.doi.org/10.1001/archderm.1989.01670190134022.

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45

&NA;. "Podophyllin should not be used in patch testing,." Reactions Weekly &NA;, no. 485 (January 1994): 5. http://dx.doi.org/10.2165/00128415-199404850-00016.

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46

&NA;. "Electrodesiccation has greater efficacy than cryotherapy and podophyllin." Inpharma Weekly &NA;, no. 730 (March 1990): 13. http://dx.doi.org/10.2165/00128413-199007300-00030.

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47

von Krogh, G. "Podophyllin office therapy against condyloma should be abandoned." Sexually Transmitted Infections 77, no. 6 (December 1, 2001): 409–12. http://dx.doi.org/10.1136/sti.77.6.409.

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48

Bargman, Howard. "Is Podophyllin Safe for Use in Pregnancy?-Reply." Archives of Dermatology 125, no. 7 (July 1, 1989): 1001. http://dx.doi.org/10.1001/archderm.1989.01670190135023.

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49

Douglas, J. M., L. J. Eron, F. N. Judson, M. Rogers, M. B. Alder, E. Taylor, D. Tanner, and E. Peets. "A Randomized Trial of Combination Therapy with Intralesional Interferon 2b and Podophyllin Versus Podophyllin Alone for the Therapy of Anogenital Warts." Journal of Infectious Diseases 162, no. 1 (July 1, 1990): 52–59. http://dx.doi.org/10.1093/infdis/162.1.52.

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50

Sharquie, Khalifa E., Adil A. Noaimi, and Wesal K. Al-Janabi. "Podophyllin (10%) Ointment: A New Therapeutic Modality for Psoriasis." Journal of Cosmetics, Dermatological Sciences and Applications 03, no. 04 (2013): 243–49. http://dx.doi.org/10.4236/jcdsa.2013.34037.

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