Dissertations / Theses on the topic 'Poetry and medicine'

This thesis investigates the use of medical terminology in the expression of religious selfhood in the late sixteenth and early seventeenth centuries. Concentrating on the period between 1590 and 1640, I examine how the diffusion of medical learning and its key vocabularies into wider cultural contexts offered writers new ways in which to interpret the body’s functions in relation to religious doctrine. Focusing on the physiology of the humoral system and the physical and religious ‘passions’, I explore how an increased use of medical terminology can support or problematize the individual’s relationship with their own body and the religious doctrine to which they adhere. Through extensive use of primary medical and religious texts, I show that knowledge of medical terminology is employed with greater specificity than has previously been considered, evidencing a lively correspondence of ideas for writers working towards a systematic understanding of the religious significance of the body.

During my time at Harvard Medical School (HMS), I have been fortunate enough to be able to continue pursuing a unique passion of mine. Spoken word poetry is a passion that falls far from the traditional medical school curriculum. In this paper, however, I will argue that this need not be the case. I will argue that spoken word poetry has an important role to play in the education and professional development of physicians and other health care providers. First, I will present a brief history of spoken word poetry. My intent here is to orient my audience, composed mostly of academic physicians, to this rich and fascinating genre of performance art. Next, I will provide an overview of how poetry and other forms of creative writing are already being used to help train more well-rounded, humanistic physicians. I will describe how the inclusion of spoken word poetry in particular has the potential to enhance these initiatives in unique and powerful ways. Finally, I will present an original curriculum made up of four contiguous spoken word poetry workshops specifically geared towards medical students and physicians. This course will be designed in the spirit of month-long electives at my home institution and at many other medical schools. It is my hope that through this project, I might help academic physicians gain a greater appreciation for the unconventional art form that is spoken word poetry and for the role it might play in advancing our profession, our relationships to patients, and ultimately our patients’ outcomes.

Thesis (M.A.)--Indiana University, 2009.
Department of Philosophy, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Peg Brand, James Capshew, Richard Gunderman, Jane E. Schultz. Includes vitae. Includes bibliographical references (leaves 117-122).

Thesis (Ph. D.)--University of Oregon, 2003.
Typescript. Includes vita and abstract. Includes bibliographical references (leaves 263-277). Also available for download via the World Wide Web; free to University of Oregon users.

The period spanning from the late 1850s to the mid-1860s frames a historical moment in Victorian England when lactation and breastfeeding came under intense public scrutiny in both medical and creative writing. While popular domestic author Isabella Beeton wrote on the dangers that an unwary mother’s milk represented for her child and herself in her serial publication, Mrs. Beeton’s Book of Household Management (1859-1861), prominent physicians C.H.F. Routh and William Acton launched a public dispute in medical journals contesting the physiological and moral dangers that the fallen wet nurse posed for the middle-class household (1859). Meanwhile, the medical community catalogued the bizarre long-term physical and dispositional side-effects of an infant’s consumption of “bad milk” – among them, syphilis, swearing, sexual immorality, and death (Matus 161-162). But it is not only medical writers who were latching on to the breastfeeding debate as a means of voicing social and political concerns of the day; recent literary critics have gestured towards the troubling manifestations of lactation in popular mid-century novels like Charles Dickens’s Dombey and Son (1848) and George Eliot’s Adam Bede (1859) as entry points into Victorian anxieties about classed and gendered embodiment. This project stipulates that the mid-century preoccupation with managing women’s milk represents an intersection of two overlapping cultural paradigms pertaining to female expression: a cultural devaluation of female physiological expression as unconscious if not dangerous leakage, and a deprecation of female linguistic and poetic expression as an analogously unmeditated and potentially disruptive kind of communication. Mid-century manuals, articles, and novels offered public voice to a number of existing anxieties surrounding breastfeeding which accompanied the mid-nineteenth century, a historical moment at the cusp of a waning popularity in wet nursing and at the advent and rise of patented infant formula. This project stipulates that at least three female poets of the mid-nineteenth century employ lactation imagery in their works as a means of recasting a cultural devaluation of female expression – inventing a new critical terminology of feminine poetic signifiers that uses the symbolic medium of breastmilk as its ink. Informed by the medical and cultural context of the High Victorian age, I explore how poets Elizabeth Barrett Browning (1806-1861), Christina Rossetti (1830-1894), and Augusta Webster (1837-1894) not only participate in the preoccupation with unstable bodies and fluids, but capitalize on female leakage in an elaborate rhetorical strategy that embarks on a new embodied female poetics. Barrett Browning’s Aurora Leigh, Rossetti’s “Goblin Market,” and Webster’s Mother and Daughter all enlist the lactating and feeding breast in a series of elaborate metaphors of female identity construction, literary expression, and poetic voice.

This research explores the experience of participation in a pilot program that integrated poetry and photography for a group of seven adults living with severe and persistent mental illness. Data was gathered in the form of written, visual and verbal responses generated through a semistructured, qualitative focus group that took the week after the end of the pilot program. The data was categorized and coded using a analytical procedure based on Photovoice, a participatory action research model that seeks to empower research participants by providing them with cameras to document and share issues of importance to their lives. Analysis of the data resulted in the emergence of six overarching themes: 1) The group experience 2) Self vs. other 3) Accomplishment and challenge 4) Confinement vs. freedom 5) Observing vs. Being observed/new perspectives and 6) Memories recalled. These themes were examined against existing literature about the use of photography and poetry in therapy, arts-based and group therapy treatments of severe and persistent mental illness, and the use of participatory and artsbased research in mental health. The findings of this research emphasize the rich possibilities for incorporating linked language/written and visual interventions in the treatment of severe and persistent mental illness, as the two offer complementary but distinct opportunities for healing, growth and self-expression. Moreover, this study demonstrates the importance of including mental health clients as participants in qualitative research regarding their perceptions of treatment, and the fundamentally empowering experience of being viewed and treated as experts on their own lives.

This thesis explores the significance of John Keats's medical Notebook, and his time at Guy's Hospital (October 1815 – March 1817), for the poet's career. As a primary contribution, it offers a new transcription of Keats's medical Notebook (Appendix 1). The transcription reproduces Keats's text and indicates the layout of his notes, but is neither a facsimile, nor a new edition: the visual form of Keats's notes is not reproduced, nor do I offer critical annotations; commentary follows in subsequent chapters. The achievements, limitations and influence of the only edition of Keats's medical Notebook — Maurice Buxton Forman's from 1934 — are the subject of the first chapter, which also considers accounts of Keats's medical career in Keats biography and criticism. Chapter two focuses on the poems Keats wrote while at Guy's to show that the two aspects of his life — medicine and poetry — were mutually influential. Chapter three considers Keats's medical notes in comparison to a fellow-student's, indicating how some characteristics of Keats's note-taking prefigure aspects of his mature poetry. Chapter four finds Endymion suffused with medical knowledge and imagery, and argues that this was a vital aspect of the poem's depiction of passion. Chapter five suggests that the publication of Keats's 1820 volume was greatly influenced by questions of health, medicine, and disease; concerns reflected by the poems in it, which also reveal the extent of Keats's continued awareness of, and interest in, contemporary medical thought. In sum, the thesis argues that the origins of Keats's poetic achievement can be traced in his medical Notebook and ‘hospital' poems, and that the ability to infuse his poetry with medical knowledge was a vital component of Keats's poetic power and achievement.

La Medicina de pecat és un extens tractat en vers de Ramon Llull concebut per a la direcció espiritual dels cristians pecadors que, mitjançant la pràctica d’exercicis devocionals i doctrinals, volen purificar la seva ànima i encaminar-se a la via de salut eterna. L’estructura de l’obra està integrada per diferents parts i capítols que constitueixen unitats formals i de sentit, les quals poden ser llegides per separat. Aquesta característica va donar lloc, des de ben aviat, a una doble transmissió del text: la del tractat com a conjunt compost per diverses parts i la d’unitats parcials del text que han estat desvinculades de la macroestructura i difoses com a opuscles autònoms. Aquesta tesi doctoral té l’objectiu d’oferir un estudi del conjunt de la tradició de la Medicina de pecat, una reconstrucció del text basada en l’anàlisi ecdòtica de tota la tradició i una interpretació del tractat en vers que tingui en compte la posició que ocupa aquest text en el marc de la producció lul·liana i en relació amb el conjunt d’estratègies desenvolupades per l’autor per tal de promoure el seu programa intel·lectual i els seus projectes missionals d’una manera eficaç. Amb aquest propòsit, s’han ordenat i analitzat totes les dades textuals i històriques conegudes que fan referència a la composició i a la transmissió de la Medicina de pecat i s’ha preparat una edició crítica del text complet de l’obra, la primera que té en compte tota la tradició manuscrita conservada i que respon a uns criteris filològics objectius.
The Medicina de pecat is a long treatise in verse by Ramon Llull that was conceived as a spiritual guide for Christian sinners who, through the practice of devotional and doctrinal exercises, want to purify their soul and find their way towards eternal salvation. The structure of this work consists of different parts and chapters that constitute formal and meaningful units, which are susceptible to being read separately from the main piece. Soon this feature caused the text to be disseminated in two different ways: on the one hand, the treatise as a piece consisting of different parts; and, on the other hand, some text units that were disassociated from the macro-structure and disseminated as independent opuscules. This doctoral thesis aims to offer a study of the whole tradition of the Medicina de pecat, a reconstruction of the text based on an ecdotic analysis of all its tradition, and an interpretation of the versed treatise in which two main aspects are considered: the position of the work regarding Ramon Llull’s oeuvre and the strategies carried out by Llull to effectively promote his intellectual programme and his missionary projects. To the purpose of this study, all textual and historical extant-data regarding the composition and the dissemination of the Medicina de pecat have been sorted and analysed, and a critical edition of the complete text has been prepared, which is the first one that takes into account the entire textual tradition preserved and that is based on philological objective criteria.

Projektet har utvecklats i interdisciplinärt samarbete mellan Jenny Wiklund och KTH, Akademiska Sjukhuset i Uppsala, Uppsala Universitet, Karolinska Institutet, Kungl. Konsthögskolan, Aarhus Arkitektskole, och curator Jan Åman. Projektet har utvecklats skulpturalt vid Kungl. Konsthögskolan. Förstudier har genomförts vid Karolinska Universitetssjukhuset. I finalstudien kombineras studier vid Uppsala Akademiska Sjukhuset, Bild- och Funktionsmedicinskt centrum/Röntgen i tredimensionell visualisering av medicinsk bild med studier i klinisk anatomi vid Uppsala Universitet, för att förenas i skulptural gestaltning och iscensättning. R1 Reaktorhallen iscensätts som ett platsspecifikt monumentalverk. Den fysiska installationen i rummet bildar en temporal kappa om utställningskapitlen i avhandlingsutställningen som handlar om kropp och hjärna. Utställningen berättar om en specifik tidpunkt, utan minne och proprioception. Här finns ingen historia och ingen framtid. Genom utställningen skapas en förståelse för sambanden mellan teoretiskt tänkande och visuell gestaltning. Det är forskning genom konstnärlig och arkitektonisk precision med referenser till konst, arkitektur, medicin och medicinsk teknik. Referenserna är från verkliga objekt i verkliga rum, specifika verk från specifika konstnärer och genom auskultering vid flertalet expertpresentationer, där människor genom närvaro förmedlat sin kunskap. Arkitektur är spatial konstruktion av identitet, här i utställningsform som temporal visuell spatial-estetisk poetik. Formen på framläggningen av avhandlingen är vald efter det huvudsakliga ämnet som utreds, minnet, och dess temporala omskapande av rummet vid varje specifik tidpunkt det framkallas. Det visuella intrycket kommer före alla andra beskrivningar, i logik med den händelse som föregick doktorandprojektets ämne, en minnesförlust, där upplevelsen av rummet kom före språket, kroppen före hjärnan, intränade minnen i form av siffror före en självbiografi.
The project was developed in co-operation between Jenny Wiklund and KTH, Uppsala University Hospital, Uppsala University, Karolinska Institute, Royal Institute of Art, Aarhus School of Architecture, and curator Jan Åman. The project was developed sculpturally at the Royal Institute of Art. Preliminary studies of medicine were made at Karolinska University Hospital. The final study combines studies at Uppsala University Hospital of three-dimensional visualization of medical imaging with studies of clinical anatomy at Uppsala University, to be amalgamated to a sculptural interpretation and production. R1, the Reactor Hall, is staged as a site-specific monumental artistic work. The installation provides a temporary coat around the chapters of the dissertation exhibition, dealing with body and brain. The exhibition tells us about a specific moment, there is no memory, nor proprioception. There is no history, nor future. Through the exhibition an understanding of the connection between theoretical thinking and visual interpretation emerges. It is research by artistic and architectonic precision with references to art, architecture, medicine and medical technique. References come from concrete objects in concrete rooms, from specific artistic work of individual artists and from auscultating a number of expert presentations, where people by presence conveyed their knowledge. Architecture is a spatial construction of identity, here in the form of an exhibition as temporary visual spatial-aesthetic poetic theory. The form of the dissertation was chosen due to the main subject investigated, memory, and its temporary reshaping of the room at each specific point of time it is aroused. The visual impression come before all other descriptions, logical to the event that preceded the subject of the project, a loss of memory, when the experience of the room came before the language, the body before the brain, trained memories in the form of figures before an autobiography.

Avhandlingen består av utställning med tillhörande text. Textdelen publiceras i DiVA samtidigt som utställningen är öppen.

QC 20170907

Dissertação(mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Curso de Pós-Graduação em Ciências da Saúde
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A exposição à poeira do algodão na indústria têxtil está relacionada a doenças respiratórias ocupacionais. O objetivo primário deste estudo foi investigar a relação entre a presença de sintomas respiratórios (tais como tosse e expectoração crônicas) e exposição atual (não-cumulativa) à poeira do algodão. Para tanto, realizamos um estudo epidemiológico transversal em três indústrias têxteis de grande porte, localizadas na cidade de Brusque (SC) equipadas com sistema de ar condicionado e exaustão para diminuir a exposição à poeira do algodão. A intensidade da exposição à poeira do algodão, nestas três indústrias, foi examinada através de um analisador de particulado do ar ambiente (HIAC-ROYCOâ-E.U.A.). Um total de 601 trabalhadores foram selecionados aleatoriamente para responder questionário auto-aplicável, validado, desenvolvido pela Sociedade Americana do Tórax (ATS-DLD-78). O índice de resposta foi 85,8%. Em algumas áreas, foram encontradas concentrações 1,5-5,0 vezes superiores àquelas permitidas; Setenta e um porcento dos participantes estavam expostos a concentrações superiores às permitidas pelas normas técnicas americanas. As características demográficas dos trabalhadores expostos, exceto pela presença de exposição, foram similares às dos não-expostos, predominando adultos jovens (idade média de 37,3 vs. 36,9 anos, respectivamente), do sexo masculino (84,5 vs. 76,6%, respectivamente) e não-fumantes (69,0 % vs. 73,1%). O tempo de trabalho nas indústrias não diferiu entre os dois grupos. Mais da metade dos participantes (57,5%) relatou algum sintoma respiratório. Os sintomas mais freqüentemente relatados foram, tosse com expectoração persistentes, dispnéia aos esforços, crises de sibilos e sibilos alguma vez no passado. Estes sintomas foram significativamente mais freqüentes nos trabalhadores fumantes, expostos ou não e nos não-fumantes expostos do que nos não fumantes não-expostos. Após controlar para idade, tabagismo, e relato de asma alguma vez no passado, os resultados da análise [odds ratios de prevalência (95% IC)] mostraram que trabalhadores expostos à poeira de algodão tiveram uma chance maior de relatar tosse com expectoração persistentes [1,8 (1,1 - 3,1)] na tabela IX e dispnéia aos esforços [2,2 (1,3 - 3,6)] na tabela IX ,mas não sibilos alguma vez no passado e crises de sibilos, do que os trabalhadores não-expostos. Asma alguma vez no passado foi o principal fator associado a todos os sintomas respiratórios analisados. Os resultados mostraram que a exposição a níveis de poeira do algodão acima dos limites de tolerância permitidos, está associado com um aumento da prevalência de sintomas respiratórios, especialmente tosse com expectoração crônicas e dispnéia aos esforços.

This thesis is the first sustained study of the poet John Clare and his relationship to health. It considers health as an under-explored physical and mental state evoked across his poetry and prose that has heretofore been overshadowed by a critical preoccupation with his supposed madness. Under the banner of the Medical Humanities, I angle a critical lens on Clare and health beyond biographical readings of his mental deterioration and onto his written responses to the medical, cultural, and social understandings of health by which he was surrounded. Specifically, I argue that Clare articulates both his comprehension and also experience of health through poetic form. I take a thematic approach to the reach of Clare's works composed between 1804-1864, and focus on what I argue to be the most predominant 'forms' that health takes across his poetics: voice, breath, and place. The chapters unfold the poet's engagement with eighteenth- and nineteenth-century medical contexts such as nosology and theories of insanity, speech and elocution, climatic and atmospheric medicine, phrenology, and botany, in order to consider how the local formal techniques of his poems (metre and prosody, rhyme and other sonic devices, caesura, enjambment, and line-endings) shape and re-work the ideas of mental and physical health that these contexts put forward. Throughout the thesis I bring together formal and historical methodologies with modern phenomenological and cultural theories in order to draw out how Clare's exploration of health is both facilitated by the thinking of his own period, and also speaks to current research into health and illness as subjective experiences. Ultimately, I read health across Clare's poetry at the level of form in order to reveal how health inspires a textual mode that defies determinacy and unsettles distinctions between the healthy and the pathological. This thesis is the first sustained study of the poet John Clare and his relationship to health. It considers health as an under-explored physical and mental state evoked across his poetry and prose that has heretofore been overshadowed by a critical preoccupation with his supposed madness. Under the banner of the Medical Humanities, I angle a critical lens on Clare and health beyond biographical readings of his mental deterioration and onto his written responses to the medical, cultural, and social understandings of health by which he was surrounded. Specifically, I argue that Clare articulates both his comprehension and also experience of health through poetic form. I take a thematic approach to the reach of Clare's works composed between 1804-1864, and focus on what I argue to be the most predominant 'forms' that health takes across his poetics: voice, breath, and place. The chapters unfold the poet's engagement with eighteenth- and nineteenth-century medical contexts such as nosology and theories of insanity, speech and elocution, climatic and atmospheric medicine, phrenology, and botany, in order to consider how the local formal techniques of his poems (metre and prosody, rhyme and other sonic devices, caesura, enjambment, and line-endings) shape and re-work the ideas of mental and physical health that these contexts put forward. Throughout the thesis I bring together formal and historical methodologies with modern phenomenological and cultural theories in order to draw out how Clare's exploration of health is both facilitated by the thinking of his own period, and also speaks to current research into health and illness as subjective experiences. Ultimately, I read health across Clare's poetry at the level of form in order to reveal how health inspires a textual mode that defies determinacy and unsettles distinctions between the healthy and the pathological.

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES.
Whole-body extracts and proteins of mites are used for the diagnosis of allergic diseases in humans and animals. The objective of the present study was to evaluate the biological activity of commercial Dermatophagoides farinae and Blomia tropicalis allergenic extracts in dogs with atopic dermatitis and to identify the allergens present in these extracts by serological assays. For this purpose, 26 dogs were submitted to skin tests using commercial mite extracts (ALK-Abell? or FDA Allergenic) and skin reactions were evaluated after 15 min. Allergenic proteins present in the D. farinae and B. tropicalis extracts were identified by immunoblotting using sera from allergic animals and anti-dog IgE conjugate. The results showed that 0.95 and 1.68 BU/mL of the commercial D. farinae and B. tropicalis extracts (ALK-Abell?), respectively, are necessary to provoke a papule measuring 14 mm in diameter in susceptible animals. Immunoblotting analysis of antigens present in the D. farinae extract (FDA Allergenic) using sera from 10 allergic animals showed that 80% of the sera recognized a band of approximately 102 kDa, 80% two bands of 52 to 76 kDa, 70% two bands larger than 225 kDa, 50% one band of approximately 76 kDa, 50% one band of approximately 225 kDa, 40% one band of 31 to 38 kDa, and 20% one band of 12 to 17 kDa. Immunoblotting of antigens of the B. tropicalis extract (FDA Allergenic) showed that 50% of the sera recognized two bands of 52 to 76 kDa. These results demonstrate the importance of the two house dust mite species for the pathogenesis of canine atopic dermatitis in Brazil. In addition, the results indicate allergens that should be present in allergenic extracts used for diagnosis and allergenspecific immunotherapy.
CUNHA, Victor do Espirito Santo. Estudo da atividade biol?gica de extratos de corpo total de ?caros da poeira domiciliar em c?es com dermatite at?pica e identifica??o sorol?gica de al?rgenos. 2010. 49p Tese (Doutorado em Ci?ncias Veterin?rias, Sanidade Animal). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2010. Extratos de corpo total e prote?nas de ?caros s?o utilizados para diagn?stico de doen?as al?rgicas em seres humanos e animais. O objetivo do presente trabalho foi determinar a atividade biol?gica de extratos alerg?nicos comerciais de Dermatophagoides farinae e Blomia tropicalis em c?es com dermatitite at?pica e identificar sorologicamente al?rgenos presentes nesses extratos. Para tanto, 26 c?es foram testados intradermicamente com extratos comerciais de ?caros (ALK-ABELL? ou FDA Allergenic) e as rea??es cut?neas avaliadas ap?s 15 minutos. Prote?nas alerg?nicas presentes nos extratos de D. farinae e B. tropicalis foram identificadas por ?immunoblotting? utilizando-se soros dos animais al?rgicos e conjugado anti-IgE canina. Os resultados obtidos mostraram que, para provocar uma p?pula com 14 mm de di?metro nos animais sens?veis, s?o necess?rios 0,95 BU/mL e 1,68 BU/mL de extratos comerciais de D. farinae e B. tropicalis (ALK-ABELL?), respectivamente. A an?lise por ?immunoblotting? dos ant?genos presentes no extrato de D. farinae (FDA Allergenic), utilizando soros de dez animais al?rgicos, mostrou que 80% dos soros reconhecem uma banda com peso molecular de aproximadamente 102 kDa; 80% duas bandas entre 52 e 76 kDa; 70% duas bandas acima de 225 kDa; 50% uma banda com aproximadamente 76 kDa; 50% uma banda com aproximadamente 225 kDa; 40% uma banda entre 31 e 38 kDa; e 20% uma banda entre 12 e 17 kDa. A an?lise por ?immunoblotting? dos ant?genos do extrato de B. tropicalis (FDA Allergenic) mostrou que 50% dos soros reconhecem duas bandas com pesos moleculares entre 52 e 76 kDa. Esses resultados demonstram a import?ncia dessas duas esp?cies de ?caros da poeira domiciliar na patog?nese da dermatite at?pica canina no Brasil, assim como indicam al?rgenos que devem estar presentes nos extratos alerg?nicos utilizados para diagn?stico e imunoterapia al?rgeno-espec?fica.

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Background: Asthma is a chronic disease of the airways, characterized by bronchial inflammation and hyperresponsiveness, which affects approximately 300 million people around the world. The increase in the prevalence of asthma in recent years has been associated with an increase in vitamin D deficiency. About 1 billion people in the world have insufficient levels of vitamin D due to many factors such as reduced outdoor activities, sunscreens use and a diet low in vitamin D. In addition, many studies suggest that vitamin D deficiency has a direct effect on lung function, leading to changes in the structure of the airways and in the inflammatory process. Objectives: To evaluate the effect of vitamin D deficiency at different life stages in a murine model of allergic airways disease house dust mite (HDM) induced on inflammation and lung function. Methods: Female BALB / c mice were placed in a diet replete or deficient in vitamin D at three-week old. At 8 weeks, females were mated with males on a diet replete in vitamin D. At birth, pups were cross-fostered to assess the effects of vitamin D deficiency at different stages of life, in utero (Vit D -/+), postnatal (Vit D +/-) and whole-life (Vit D - / -) compared to the control group whole-life vitamin D replete (Vit D + / +). At 8 weeks of age, mice of both sexes were challenged for 10 consecutive days intranasally with either HDM extract or saline solution after mild anesthesia. The animals were anesthetized for lung function test and then submitted to euthanasia for bronchoalveolar lavage (BAL) and lung tissue removal 24 hours after the last intranasal challenge. The total BAL cell count and collagen quantification of lung tissue homogenized were evaluated. Results: Vitamin D deficiency did not affect HDM-induced inflammation, which was characterized by BAL eosinophilia. Vitamin D deficiency at any life stage (in utero, postnatal and all life) caused impairment of lung function, increased tissue damping and tissue elastance, being particularly observed in females. On the other hand, the asthma HDM-induced decreased airway distensibility, but only in females and vitamin D do not altered this response. Conclusion: Our results suggest that vitamin D and HDM have different mechanisms that influence in the development of allergic lung disease and furthermore the effects appear to be sex-specific.
Introdu??o: A asma ? uma doen?a cr?nica das vias a?reas, caracterizada por inflama??o e hiperresponsividade br?nquica, que atinge aproximadamente 300 milh?es de pessoas ao redor do mundo. O aumento da preval?ncia da asma nos ?ltimos anos tem sido associado ao aumento da defici?ncia de vitamina D. Cerca de 1 bilh?o de pessoas no mundo apresenta n?veis insuficientes de vitamina D em fun??o de diversos fatores, tais como a redu??o de atividades ao ar livre, uso de protetor solar e dieta pobre em vitamina D. Al?m disso, estudos sugerem que a defici?ncia de vitamina D possui um efeito direto na fun??o pulmonar, causando altera??es na estrutura das vias a?reas e no processo inflamat?rio. Objetivo: Avaliar o efeito da defici?ncia de vitamina D em diferentes est?gios da vida de camundongos com asma induzida por ?caro domiciliar (house dust mite; HDM) sobre a inflama??o e fun??o pulmonar. M?todos: Camundongos BALB/c f?meas receberam dieta rica ou deficiente em vitamina D a partir da terceira semana de vida. Com 8 semanas de vida, as f?meas foram acasaladas com machos em dieta rica em vitamina D. Ao nascimento foi realizado o cross-fostering (ado??o cruzada) com a prole para que fosse poss?vel avaliar o efeito da defici?ncia de vitamina D em diferentes est?gios da vida, in utero (Vit D -/+), p?s-natal (Vit D +/-) e durante toda a vida (Vit D -/-), em compara??o ao grupo controle, que recebeu dieta rica em vitamina D durante toda a vida (Vit D +/+). Com 8 semanas de vida, camundongos de ambos os sexos foram desafiados por 10 dias consecutivos por via intranasal, com extrato de HDM ou apenas solu??o salina. Os animais foram anestesiados para a realiza??o do teste de fun??o pulmonar e ent?o submetidos a eutan?sia para a realiza??o do lavado broncoalveolar (LBA) e retirada do tecido pulmonar, 24 horas ap?s o ?ltimo desafio intranasal. Foi avaliada a contagem total de c?lulas do LBA e quantifica??o de col?geno no homogeneizado de tecido pulmonar. Resultados: A defici?ncia de vitamina D n?o afetou a inflama??o induzida por HDM, que foi caracterizada por eosinofilia no LBA. A defici?ncia de vitamina D em qualquer fase da vida dos camundongos (in utero, p?s-natal e durante toda a vida) causou uma piora na fun??o pulmonar, aumentando o tissue damping e tissue elastance, sendo observado particularmente em f?meas. Por outro lado, a asma induzida por HDM diminuiu a distensibilidade das vias a?reas apenas em f?meas e a vitamina D n?o alterou essa resposta. Conclus?o: Nossos resultados sugerem que a vitamina D e HDM possuem diferentes mecanismos que influenciam no desenvolvimento da doen?a pulmonar al?rgica e, al?m disso, os efeitos parecem ser dependentes do sexo.

Canine atopic dermatitis (CAD) is a common dermatosis, defined as a genetic-based disease, which predisposes to cutaneous inflammation and pruritus, mediated by class IgE immunoglobulins directed against specific antigens in most cases. Clinical diagnosis may be later complemented by skin allergic and/or serological tests (ELISA). The aim of these tests is to identify possible allergens in order to enable the clinicians to select candidate antigens for allergen specific immunotherapy. This work aimed to identify the sensitization profile of 58 dogs with atopic dermatitis diagnosis. All animals were submitted to intradermic test (IDT) and screened for the presence of antibodies against different allergens using a serologic test. House dust mites are described as the most frequent allergens in all continents. However, the positivity to C. dactylon is not commonly described and may be characteristic for the region. With this work it was possible to identify the main allergens involved in the immunologic response of atopic dogs residing in Rio Grande do Sul, pointing to the importance to include C. dactylon in screening tests for allergy.
A dermatite atópica canina (DAC) é uma dermatose comum, definida como uma doença de cunho genético que predispõe à inflamação e ao prurido cutâneo, mediada por imunoglobulinas da classe IgE dirigidas contra antígenos específicos na maior parte dos casos. O diagnóstico da DAC é clínico e pode ser posteriormente complementado por testes alérgicos cutâneos e/ou sorológicos. O objetivo desses testes é identificar possíveis alérgenos e, com isso, possibilitar ao clínico a seleção de antígenos candidatos para a imunoterapia alérgeno-específica. No presente trabalho buscou-se identificar o perfil de sensibilização de 58 cães diagnosticados com dermatite atópica. Todos os animais foram submetidos ao teste intradérmico (TID) e à detecção de anticorpos específicos para diferentes alérgenos através de teste sorológico (ELISA). Os ácaros domiciliares são descritos como os alérgenos mais frequentes em todos os continentes. Entretanto, a positividade ao C. dactylon não é usualmente descrita e pode ser característica da região. Com esse trabalho foi possível identificar os principais alérgenos envolvidos na resposta imunológica de cães atópicos residentes no Rio Grande do Sul, ressaltando-se a importância da inclusão do extrato de C. dactylon em testes alérgicos.

This thesis and its corresponding art installation, Lessons from Ziggy, attempts to deconstruct the variables prevalent within several complex systems, analyze their transformations, and propose a methodology for reasserting the soap box within the display pedestal. In this text, there are several key and specific examples of the transformation of various signifiers (i.e. media-bred fear’s transformation into a political tactic of surveillance, contemporary freneticism’s transformation into complacency, and community’s transformation into nationalism as a state weapon). In this essay, all of these concepts are contextualized within the exponential growth of new technologies. That is to say, all of these semiotic developments must be framed within the post-Internet sphere.

The following is a collection of original poetry. The manuscript consists of an introduction explaining influences and style, and four chapters of poems categorized by subject matter: object/nature, writing/creativity, relationships, and family/figures. INDEX WORDS: Poetry, Poem

This thesis discusses Lorenzo de' Medici's era and literary work. In the first part, Lorenzo's personage is introduced and put into historical and cultural context. Given its importance for social changes, a separate chapter is dedicated to humanism and its eminent personalities. Neoplatonism and Lorenzo's patronage and cultural activities are also mentioned. The second part of the thesis is dedicated to Lorenzo de' Medici's own literary work, paying particular attention to his comical poems inspired by rustic life, especially some of his carnival chants (canti carnascialechi) and the poem Nencia da Barberino, which are then analyzed. In the conclusion, this study briefly deals with the controversy caused by the connection between Lorenzo's poetry and his government. Keywords: Lorenzo de' Medici, humanism, Neoplatonism, volgare, patronage, comical and realistic poetry, carnival chants.

In my dissertation, I argue that the medical milieu of the 13th century contributed to shape vernacular secular culture. I demonstrate how the historical and scientific contexts of the Italian peninsula, from the Sicilian school of Frederick II and Manfred to the communal realities of Bologna and Florence, testify to the active reception of the works of Aristotle, Galen, and their Arabic and Western commentators in poetic circles. I show how the Italian 13th century was informed by a high degree of intellectual and scientific knowledge, and how the far-reaching penetration of medical sources connects an emerging vernacular culture to the intricacy of urban networks. "Of Poets and Physicians" addresses the following questions: what is the contribution of medical literature to Italian poetry of the 13th century? How can the reception of Aristotelian and Galenic physiological theories help us illuminate the way Medieval literature produced its tropes? Why should we consider these cultural and intellectual environments as productive frames of thought for poetical writings? My dissertation addresses these questions in three macro-chapters. In the first chapter (On Fluid Memory), I argue that under the patronage and influence of Frederick II and Manfred, the reception of Aristotle’s physiology of the soul informed the tropes of the memory image of the lady engraved into the heart, used by Giacomo da Lentini and the other vernacular poets at court. In the second chapter (Minding the Brain), I study the influence of Galen and Arabic Galenism on the intellectual circles of the second half of the 13th century. I argue that the influence of the Bolognese Galenism of Taddeo Alderotti informed a great part of Guinizzelli’s poetry, not only with respect to the phenomenology of love, but also in his views on nobility and natural determinism. In the third chapter (All Things Natural), I combine the Aristotelian discourse on ethics and the Galenic question of temperamental determinism. I analyze how the scientific background on the relationship between bodily balance and the functions of the soul is discussed in Taddeo Alderotti’s translation of an epitome of Aristotelian ethics, and how these debates are reframed in the poetry of Guido Cavalcanti, Dante Alighieri, and Cino da Pistoia, by virtue of the relationship between love and reason. While contextualizing the uses of medical thought in the poetical production of philosophical and poetic authors, I demonstrate how the active reception of scientific theories testifies to the high degree and pervasiveness of medical education in the intellectual circles of the 13th century.

The doctoral thesis The World of Italian Comic-Realistic Poetry maps in a mostly chronological order the type of Italian poetry that is often referred to as 'giocosa' or 'comico- realistica' - in Czech translation, this best corresponds to 'poezie komicko-realistická'. The principal themes and individual topoi within the genre are analysed one by one, and examples are introduced to demonstrate the propositions related to the existence, characteristics and quality of the genre and the comic contained therein. The introduction is followed by an analysis of comic-realistic poetry of the first period which saw its heyday, namely, the first half of the 14th century, roughly comprising the years 1280- 1340. Following an analysis of sonnets by Rustico di Filippi, who is considered the emblematic founder of the genre in Italy, various topics are gradually analysed such as Bakhtinian reversal in values and seeming protest against the world, poverty and money, woman and anti-stilnovismo in sonnets of a great number of poets of the time, the most typical of them being Cecco Angiolieri. Topics with a more realistic background are also included, religious and political sonnets in particular. The issue of autobiography or pseudo- autobiography in comic-realistic texts is also covered in detail. Based on the...

This qualitative study uses narrative inquiry (Connelly & Clandinin, 1988, 1990, 2001) and self-study to investigate ways to further understand and facilitate the integration of holistic philosophies of education with media literacy pedagogies. As founder and director of the Youth Media Literacy Project and a self-titled Imagitator (one who agitates imagination), I have spent over 10 years teaching media literacy in various high schools, universities, and community centres across North America. This study will focus on my own personal practical knowledge (Connelly & Clandinin, 1982) as a culture jammer, educator and cancer survivor to illustrate my original vision of a ‘holistic media literacy pedagogy’. This research reflects on the emergence and impact of holistic media literacy in my personal and professional life and also draws from relevant interdisciplinary literature to challenge and synthesize current insights and theories of media literacy, holistic education and culture jamming.