Relevant bibliographies by topics / Points aberrants

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Points aberrants'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Points aberrants.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Points aberrants"

1

Huot, Guy. "L’effet des points aberrants dans la désaisonnalisation." Articles 57, no. 3 (January 21, 2009): 407–22. http://dx.doi.org/10.7202/600992ar.

Full text
Abstract:
ABSTRACT This article is devoted to an improved estimation of the seasonal factors in the X-11-ARIMA method given the presence of outliers in the unadjusted series. The series are modelled by an ARIMA process and the outliers are identified relative to the fitted values of the model. They are then replaced by their corresponding function values. A good replacement of the outliers improves both the performance of the ARIMA model fitted to the modified series and the revisions to the seasonal factors, especially the latter.
APA, Harvard, Vancouver, ISO, and other styles
2

Ye Qingwei, Wang Dandan, and Zhou Yu. "Aberrant Point Clustering and Elimination of Vibration Signal." INTERNATIONAL JOURNAL ON Advances in Information Sciences and Service Sciences 5, no. 6 (March 31, 2013): 110–18. http://dx.doi.org/10.4156/aiss.vol5.issue6.14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Shao, Hai-peng, Juan Yin, Wen-hao Yu, and Qiu-ling Wang. "Aberrant Driving Behaviours on Risk Involvement among Drivers in China." Journal of Advanced Transportation 2020 (June 29, 2020): 1–8. http://dx.doi.org/10.1155/2020/8878711.

Full text
Abstract:
The purpose of this study is to validate the version of Driver Behaviour Questionnaire (DBQ) by considering distractions, fatigue, and drunk driving, the main reasons for accidents in China, as independent parts of violations and errors and further explore the effects of demographic/driving variables and all factors on risk involvement (accident involvement and penalized points). 241 drivers filled in a self-completion questionnaire with 28 items conducted in Xi’an in August 2018. Exploratory factor analysis confirmed a five-factor structure, including violations, distracted driving, errors, drunk driving, and fatigued driving. The frequency of aberrant driving behaviours indicated that distractions were the most prevalent behaviours followed by fatigue. The results showed that drivers with lower education and longer annual mileages were positive with accident involvement while there was no significance in penalized points. Violations and distractions were important factors causing both accidents and penalized points. Therefore, it is effective to reduce accident involvement by establishing educational training and related laws or installing intelligent monitor vehicle equipment to warn drivers to improve safety.
APA, Harvard, Vancouver, ISO, and other styles
4

Theofani, Efthymia, Spyridon Alexis, Paul Costeas, Christos Andriopoulos, Georgia Feleskoura, Panagiotis Zikos, Anthi Aktypi, Alexandros Spyridonidis, and Konstantina Nika. "Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling." Blood Advances 2, no. 8 (April 18, 2018): 877–82. http://dx.doi.org/10.1182/bloodadvances.2017015321.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Hawke, Lindsey, Mackenzie L. Bowman, Man-Chiu Poon, Mary-Frances Scully, Georges-Etienne Rivard, and Paula D. James. "Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism." Blood 128, no. 4 (July 28, 2016): 584–93. http://dx.doi.org/10.1182/blood-2015-10-678052.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Siwaponanan, Panjaree, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton, et al. "Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients." Blood 129, no. 23 (June 8, 2017): 3087–99. http://dx.doi.org/10.1182/blood-2016-07-730135.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Manara, Elena, Emma Baron, Claudia Tregnago, Sanja Aveic, Valeria Bisio, Silvia Bresolin, Riccardo Masetti, Franco Locatelli, Giuseppe Basso, and Martina Pigazzi. "MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia." Blood 124, no. 2 (July 10, 2014): 263–72. http://dx.doi.org/10.1182/blood-2013-09-525741.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Pellagatti, Andrea, Richard N. Armstrong, Violetta Steeples, Eshita Sharma, Emmanouela Repapi, Shalini Singh, Andrea Sanchi, et al. "Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations." Blood 132, no. 12 (September 20, 2018): 1225–40. http://dx.doi.org/10.1182/blood-2018-04-843771.

Full text
Abstract:
Key Points RNA-seq analysis of CD34+ cells identifies novel aberrantly spliced genes and dysregulated pathways in splicing factor mutant MDS. Aberrantly spliced isoforms predict MDS survival and implicate dysregulation of focal adhesion and exosomes as drivers of poor survival.
APA, Harvard, Vancouver, ISO, and other styles
9

Kamijo, Hiroaki, Tomomitsu Miyagaki, Naomi Shishido-Takahashi, Rina Nakajima, Tomonori Oka, Hiraku Suga, Makoto Sugaya, and Shinichi Sato. "Aberrant CD137 ligand expression induced by GATA6 overexpression promotes tumor progression in cutaneous T-cell lymphoma." Blood 132, no. 18 (November 1, 2018): 1922–35. http://dx.doi.org/10.1182/blood-2018-04-845834.

Full text
Abstract:
Key Points Overexpression of GATA6 induces aberrant CD137L expression on tumor cells of CTCL. CD137-CD137L interactions promote cell proliferation and migration in CTCL cells, representing potential therapeutic targets.
APA, Harvard, Vancouver, ISO, and other styles
10

Hilcenko, Christine, Paul J. Simpson, Andrew J. Finch, Frank R. Bowler, Mark J. Churcher, Li Jin, Len C. Packman, et al. "Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia." Blood 121, no. 6 (February 7, 2013): 1028–38. http://dx.doi.org/10.1182/blood-2012-10-461491.

Full text
Abstract:
Key Points Crystal structure of human USB1 identifies it as a member of the LigT-like superfamily of 2H phosphoesterases. USB1 protects spliceosomal U6 small nuclear RNA from aberrant 3′ oligoadenylation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Points aberrants"

1

Mariadassou, Mahendra. "Robustesse des arbres phylogénétiques." Phd thesis, Université Paris Sud - Paris XI, 2009. http://tel.archives-ouvertes.fr/tel-00472052.

Full text
Abstract:
La théorie synthétique de l'évolution a largement diffusé dans tous les domaines de la biologie, notamment grâce aux arbres phylogénétiques. S'ils ont une utilité évidente en génomique comparative, ils n'en sont pas moins utilisés dans de nombreux autres domaines allant de l'étude de la biodiversité à l'épidémiologie en passant par les sciences forensiques. Les arbres phylogénétiques sont non seulement une charactérisation efficace mais aussi un outil puissant pour étudier l'évolution. Cependant, toute utilisation d'arbre dans une étude suppose que l'arbre ait été correctement estimé, tant au niveau de la topologie que des autres paramètres, alors que cette estimation est un problème statistique compliqué et encore très ouvert. On admet généralement qu'on ne peut faire de bonne estimation sans les quatre pré-requis que sont (1) le choix d'un ou plusieurs gènes pertinents pour la question étudiée, (2) une quantité suffisante de données pour s'assurer une bonne précision d'estimation, (3) une méthode de reconstruction efficace qui s'appuie sur une modélisation fine de l'évolution pour minimiser les biais de reconstruction, (4) un bon échantillonnage de taxons. Nous nous intéressons dans cette thèse à quatre thèmes étroitement liés à l'un ou l'autre de ces pré-requis. Dans la première partie, nous utilisons des inégalités de concentration pour étudier le lien entre précision d'estimation et quantité de données. Nous proposons ensuite une méthode basée sur des extensions de Edgeworth pour tester la congruence phylogénétique d'un nouveau gène avec ses prédécesseurs. Dans la deuxième partie, nous proposons deux méthodes, inspirées des analyses de sensibilités, pour détecter les sites et taxons aberrants. Ces points aberrants peuvent nuire à la robustesse des estimateurs et nous montrons sur des exemples comment quelques observations aberrantes seulement suffisent à drastiquement modifier les estimateurs. Nous discutons les implications de ces résultats et montrons comment augmenter la robustesse de l'estimateur de l'arbre en présence d'observations aberrantes.
APA, Harvard, Vancouver, ISO, and other styles
2

Le, Goïc Gaëtan. "Qualité géométrique & aspect des surfaces : approches locales et globales." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00777746.

Full text
Abstract:
Parmi tous les leviers à disposition des entreprises, la prise en compte de la perception par les clients est aujourd'hui centrale, dès la conception des produits. En effet, le consommateur est aujourd'hui mieux informé et attentif à ce qu'il perçoit de la qualité d'un produit et cette perception lui permet d'établir une valeur d'estime de la qualité esthétique des produits, mais aussi de ses fonctionnalités techniques. La méthodologie de l'analyse de la qualité d'aspect des surfaces est donc un enjeu essentiel pour l'industrie. Deux approches de la fonctionnalité des surfaces sont proposées afin de formaliser la méthodologie de détection, et d'apporter aux experts des critères objectifs d'évaluation des anomalies. La première approche proposée est basée sur la métrologie des surfaces. Elle consiste à analyser les topographies mesurées pour lier la fonction aspect aux caractéristiques géométriques extraites. Une approche multi-échelle basée sur la Décomposition Modale Discrète est mise en oeuvre afin de séparer efficacement les différents ordres de variations géométriques d'une surface, et ainsi d'isoler les anomalies d'aspect. D'autre part, cette méthode permet la mise en oeuvre du calcul des courbures sur une surface de façon simplifiée et robuste. On montre que cet attribut géométrique apporte une information supplémentaire et pertinente en lien avec la fonction aspect. Enfin, ces travaux ont mis en évidence l'importance de la qualité des données sources pour analyser l'aspect, et particulièrement deux difficultés d'ordre métrologiques, liées à la présence de points aberrants (hautes fréquences) et de variations géométriques non intrinsèques aux surfaces, générées par le moyen de mesure (basses fréquences). Une méthode innovante d'identification des points aberrants dédiée à la métrologie des surfaces et basée sur une approche statistique multi-échelle est proposée. La problématique des variations géométriques liées aux tables de positionnement du moyen de mesure est traitée au moyen de la Décomposition Modale, et un protocole pour corriger ces variations est présenté. La seconde approche, plus globale, est basée sur l'interaction entre les surfaces et l'environnement lumineux. L'objet de cette approche de l'analyse de l'aspect est d'apporter une aide aux experts pour mieux détecter les anomalies. Les travaux présentés sont basés sur la technique Polynomial Texture Mappings et consistent à modéliser la réflectance en chaque point des surfaces afin de simuler le rendu visuel sous un éclairage quelconque, à la manière de ce que font les opérateurs en analyse sensorielle pour faciliter la détection. Un dispositif d'aide à l'inspection des surfaces basé sur ce principe est présenté. Enfin, une approche industrielle est proposée afin de montrer comment ces 2 axes de recherche peuvent être complémentaires dans le cadre d'une méthodologie globale, industrielle, de l'analyse de la qualité d'aspect de surfaces.
APA, Harvard, Vancouver, ISO, and other styles
3

Lee, Philseok. "Detecting Aberrant Responding on Unidimensional Pairwise Preference Tests: An Application of based on the Zinnes Griggs Ideal Point IRT Model." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4527.

Full text
Abstract:
This study investigated the efficacy of the lz person fit statistic for detecting aberrant responding with unidimensional pairwise preference (UPP) measures, constructed and scored based on the Zinnes-Griggs (ZG, 1974) IRT model, which has been used for a variety of recent noncognitive testing applications. Because UPP measures are used to collect both "self-" and "other-" reports, I explored the capability of lz to detect two of the most common and potentially detrimental response sets, namely fake good and random responding. The effectiveness of lz was studied using empirical and theoretical critical values for classification, along with test length, test information, the type of statement parameters, and the percentage of items answered aberrantly (20%, 50%, 100%). We found that lz was ineffective in detecting fake good responding, with power approaching zero in the 100% aberrance conditions. However, lz was highly effective in detecting random responding, with power approaching 1.0 in long-test, high information conditions, and there was no diminution in efficacy when using marginal maximum likelihood estimates of statement parameters in place of the true values. Although using empirical critical values for classification provided slightly higher power and more accurate Type I error rates, theoretical critical values, corresponding to a standard normal distribution, provided nearly as good results.
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Points aberrants"

1

Hamera, Judith. Unfinished Business. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199348589.001.0001.

Full text
Abstract:
Unfinished Business argues that Michael Jackson and Detroit, both as material entities with specific histories and as representations with uncanny persistence, have something valuable to teach us about three decades of structural economic transition in the United States, and particularly about the changing nature of work and capitalism between the mid-1980s and 2016. They teach us about the racialization and aesthetics of these changes, how they operate as structures of feeling and representations as well as shifts in the dominant mode of production, and about how industrialization’s successor mode, financialization, uses imagery both very similar to and very different from that of its predecessor. The book uses the methods of performance studies to advance three major points. First, figural economies of tropes, dance and theater conventions, and actual performances shape and reflect the ways structural economic change in the United States between the mid-1980s and 2016 congeals into public spectacles, circulates through a wide variety of media, and offers “lessons” to be learned about normative and aberrant relations to capital in transitional times. Second, Michael Jackson and Detroit illuminate the operations of these figural economies with special clarity. Third, Jackson’s and Detroit’s figural potential resides in their capacities to both complicate and bring fictive coherence to the intertwining of race, work, and capital in this period. Sites examined include Jackson’s performances, media coverage of his life, plays featuring Detroit, plans for the city’s postindustrial revitalization, and Detroit installations the Heidelberg Project and Mobile Homestead.
APA, Harvard, Vancouver, ISO, and other styles
2

Nakamura, Tomohiro, and Stuart A. Lipton. Neurodegenerative Diseases as Protein Misfolding Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0002.

Full text
Abstract:
Neurodegenerative diseases (NDDs) often represent disorders of protein folding. Rather than large aggregates, recent evidence suggests that soluble oligomers of misfolded proteins are the most neurotoxic species. Emerging evidence points to small, soluble oligomers of misfolded proteins as the cause of synaptic dysfunction and loss, the major pathological correlate to disease progression in many NDDs including Alzheimer’s disease. The protein quality control machinery of the cell, which includes molecular chaperones as found in the endoplasmic reticulum (ER), the ubiquitin-proteasome system (UPS), and various forms of autophagy, can counterbalance the accumulation of misfolded proteins to some extent. Their ability to eliminate the neurotoxic effects of misfolded proteins, however, declines with age. A plausible explanation for the age-dependent deterioration of the quality control machinery involves compromise of these systems by excessive generation of reactive oxygen species (ROS), such as superoxide anion (O2-), and reactive nitrogen species (RNS), such as nitric oxide (NO). The resulting redox stress contributes to the accumulation of misfolded proteins. Here, we focus on aberrantly increased generation of NO-related species since this process appears to accelerate the manifestation of key neuropathological features, including protein misfolding. We review the chemical mechanisms of posttranslational modification by RNS such as protein S-nitrosylation of critical cysteine thiol groups and nitration of tyrosine residues, showing how they contribute to the pathogenesis of NDDs.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Points aberrants"

1

Eden, Tim. "Acute lymphoblastic leukaemia." In Oxford Textbook of Medicine, 4229–33. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.220303.

Full text
Abstract:
Genetic changes in key progenitor cells in acute lymphoblastic leukaemia (ALL) are typically either point mutations or (more frequently) translocation of proto-oncogenes to active promoter sites, with such genetic rearrangements leading to aberrant protein production. In most childhood disease the first genetic events arise in utero...
APA, Harvard, Vancouver, ISO, and other styles
2

Battersby, Paul. "Changing Patterns of Social Connection across Interventions: Unravelling Aberrant Globalisation." In Rethinking Humanitarian Intervention in the 21st Century, 94–114. Edinburgh University Press, 2017. http://dx.doi.org/10.3366/edinburgh/9781474423816.003.0005.

Full text
Abstract:
International armed interventions in intrastate conflicts are planned with the expectation that order will be restored through the controlled application of limited military force. This persuasive orthodoxy, Paul Battersby argues in his Chapter Changing Patterns of Social Connection across Interventions: Unravelling Aberrant Globalisation, endures despite the erratic course of foreign interventions in the Middle East over the past two decades. Notions of order, equilibrium or stasis imply systemic balances that, where disturbed, can be restored through counteraction. Yet, while we can gather abundant conflict data, observe events from different vantage points, correlate variables and calibrate possibilities, the calculation of future trajectories of conflict events remains an imprecise and hazardous exercise. Thus, to anticipate only positive change from the rapid assertion of overwhelming military power into faraway places is to downplay the threads of happenings, decisions, ideas and beliefs that shape the subjective realities of global security. Globalisation is aberrant in its complexity, and global dynamics do not yield simple choices between binary opposites of order and disorder, control or chaos. The search for a more nuanced understanding of security leads inescapably towards the analysis of global patterns of connection and organisation that generate and sustain multiscalar supply chains of violence.
APA, Harvard, Vancouver, ISO, and other styles
3

Hall, John A. "The Problem with Communism." In The Importance of Being Civil. Princeton University Press, 2013. http://dx.doi.org/10.23943/princeton/9780691153261.003.0009.

Full text
Abstract:
This chapter examines communism. Communism in premodern circumstances was extremely rare. It requires a very considerable break in normal societal relations in order to institutionalize it. Conquest certainly creates a break of this sort, and it is this that explains the Jesuit communist communities in Paraguay quite as much as it does Sparta. Equally, millenarian expectations of religious charisma more generally so disrupt the normal as to induce social experimentation. The general point is reinforced by the aberrant case of early Iranian communism. Here the sharing of women was suggested by a ruler, Kavadh I, who was keen to discipline his nobility; once the idea had been put into practice and the nobility weakened, its ideology then came to be adopted by Mazdak, the leader of a peasant revolt.
APA, Harvard, Vancouver, ISO, and other styles
4

Groves, Jason. "Epilogue: Dilapidated." In The Geological Unconscious, 115–38. Fordham University Press, 2020. http://dx.doi.org/10.5422/fordham/9780823288106.003.0006.

Full text
Abstract:
The conclusion reflects on the shifting relations between writing and stone as mediated by a common dilapidation. It reviews how aberrant stones and an unreliable Earth both trouble the novellas and novels considered in this book and perturb the ability of narrative to render a well-plotted world to the breaking point. To test the robustness of these claims the conclusion turns to the lapidary forms of the epigram and epigraph to explore how the shifting valence of stone and the lapidary might index planetary change. Walter Benjamin’s 1939 commentary on Bertolt Brecht’s War Primer epigrams, and in particular on a line written in chalk, offers a primer for commentary in the generalized state of war that is known as the Anthropocene, while also providing a vastly expanded set of coordinates for that commentary.
APA, Harvard, Vancouver, ISO, and other styles
5

Doleys, Daniel M., and Nicholas D. Doleys. "No Way That’s My Drug Screen." In Psychological and Psychiatric Issues in Patients with Chronic Pain, edited by Daniel M. Doleys and Nicholas D. Doleys, 147–56. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197544631.003.0017.

Full text
Abstract:
In the process of treating patients with for chronic pain with opioid type medications, the use of urine drug screens (UDS) is considered the standard of care. The frequency with which a UDS is obtained varies across different guidelines and states/medical boards. It is often associated with dosage, risk for aberrant drug behavior assessment, and ongoing compliance. Most clinicians will obtain a UDS two to four times per year, unless the circumstances require otherwise. In general, the point-of care UDS lacks the sensitivity and specificity of confirmatory testing. The prescribing clinician should (i) be familiar with various types of testing, (ii) create a relationship the testing lab performing the confirmatory testing, and (iii) acquire basic interpretation skills. Clinical decisions should be postponed pending the results of confirmatory testing. False positives, and false negatives, do occur. It behooves the clinician to have “all their ducks in row” before confronting the patient and to accurately document the consultation and decision-making process. In some instances, discontinuation of therapy may be necessary and appropriate. Other cases may be subject to remediation.
APA, Harvard, Vancouver, ISO, and other styles
6

Böckenförde, Ernst-Wolfgang, Mirjam Künkler, and Tine Stein. "Remarks on the Relationship between State and Religion in Hegel [1982]." In Religion, Law, and Democracy, 199–219. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198818632.003.0010.

Full text
Abstract:
Is and can religion be seen as a foundation of the modern state? In this article Böckenförde discusses the relationship between state and religion while reviewing Hegel’s main writings on this question. Reconstructing Hegel’s concept of the state, Böckenförde points out that for Hegel, the state is simultaneously universal and historical. It is more than the political system or government—it is the polity in general and the structured form in which the people exist. Moreover, the state is the materialization of the ethical idea as such and the manifestation of how ‘truth’ in history became reality. In Hegel’s view, ‘truth’ is ultimately God’s will in the world. Further, for Hegel, state and religion are two forms of the same substance: reason. Morality and reason are closely intertwined in Hegel. Religion is a source of morality for the people, and the state and the Church are the institutional manifestations of reason. Böckenförde shows that Hegel identifies individual conscience as the core of each person’s freedom; however, Hegel denies a right to an aberrant conscience, indicating a very limited notion of freedom. Finally, Böckenförde discusses Hegel’s philosophy in light of the state today with its separation of state and religion. Since today’s state does not consider religion as part of its foundation, in Hegel’s view it would ‘stand freely in the air’. Böckenförde concludes, contrary to Hegel, that only the democratic process and the people’s agreement on the things that cannot be voted upon can form the basis of the state.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Points aberrants"

1

Vlaisavljevich, Eli, Logan P. Janka, Keat G. Ong, and Rupak M. Rajachar. "Magnetoelastic Materials as Novel Bioactive Coatings for Bone Anchored Prostheses." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206406.

Full text
Abstract:
Enhanced fibroblast activity at the implant-soft tissue interface is a key concern to the long-term success of many implanted biomaterials. Uncontrolled fibrosis has been shown to dramatically decrease the stability, function, and lifespan of biomedical implants. Fibrosis, defined as the overgrowth of various tissues about the implant, is caused by the excess synthesis of extracellular matrix components, primarily collagen, and often leads to walling off and hardening (calcification) of tissues at the biomaterial interface (1). Fibrosis is currently a major deterrent to stable bone anchored prostheses. These bone anchored mounting systems are designed to surgically attach a prosthesis mounting post directly into a patient’s bone. The attached post protrudes from the bone through the overlying soft tissue of the amputated limb providing an external connection point for the prosthetic. Although the bone anchoring system dramatically improves prosthetic limb mechanical stability, uncontrolled fibrosis at the soft tissue-mounting post interface is a significant problem (2). The fibrosis caused from aberrant cellular growth leads to the formation of irregular skin folds that prevent proper sealing to the bone anchoring post and also serves as a site for opportunistic infection and failure of the prosthetic system.
APA, Harvard, Vancouver, ISO, and other styles
2

Reitsma, P. H., A. M. Riemens, R. M. Bertina, and E. Briít. "PROMOTOR MUTATIONS IN A PATIENT WITH HAEMOPHILIA B LEYDEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643870.

Full text
Abstract:
Haemophilia B Leyden is characterized by low levels of factor IX antigen and activity before the age of 15, whereas after puberty factor IX levels rise at a rate of about 4-5% per year. To date such a genetic variant of factor IX synthesis has been reported in two (probably related) Dutch families, in a Greek and in an American family of Armenian descent. Laboratory and clinical investigations indicate that the factor IX protein is normal but that the regulation of factor IX synthesis has come under the control of the steroid hormone testosterone. We have started to investigate the factor IX gene in a patient from a Dutch family in an attempt to explain the aberrant regulation.Southern blotting revealed no gross deletions or insertions in the factor IX gene. Therefore the promotor region of the factor IX gene was cloned and subjected to a detailed restriction enzyme analysis. This also did not indicate that significant DNA deletions or insertions had occurred. Subsequently we established the nucleotide sequence of the DNA surrounding the first exon which encompassed about 600 basepairs of the promotor region. Two deviations from previously published sequence data were recorded. Firstly, an A T change was noted in the presumed "tata" box region 20 basepairs upstream from the start site of mRNA synthesis. Secondly, at position −423 a T C change was found which lies 13 basepairs upstream from a potential alternative "tata" box.The point mutation at position −20 might well explain the failure of gene expression during the prepuberal stage of the disease. Whether the same point mutation also leads to the testosterone effects or that a second sequence variation is a prerequisite for this phenomenon remains to be established from studies on the promotor region in representatives of the Greek and American families. Eventually the introduction of chaemeric genes, containing the various promotor regions, into testosterone responsive cells should delineate the promotor sequences responsible for the variations in factor IX gene expression.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Points aberrants' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography