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Dissertations / Theses on the topic 'Poly(glutamate de benzyle)'

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Published: 4 June 2021

Last updated: 4 February 2022

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1

Jacobs, Jaco. "Poly(N-vinylpyrrolidone) - Poly(γ-benzyl-L-glutamate) conjugates". Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20369.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The combination of natural and synthetic polymers allow for the synthesis of advanced hybrid copolymers. These hybrid copolymers have applications in biomedical areas, one such area being in drug delivery systems (DDS). In this study, a modular approach was used to prepare amphiphilic block copolymers with the ability to self-assemble into three dimensional structures. Reversible addition-fragmentation chain transfer (RAFT) was the synthetic tool used to mediate the polymerization of N-vinylpyrrolidone. RAFT is a versatile

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2

Martinez, Barbosa Maria Elisa. "Synthèse de dérivés du poly(L-glutamate de γ-benzyle) : préparation et caractérisation de nanoparticules mutlifonctionnelles". Paris 11, 2006. http://www.theses.fr/2006PA114835.

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Conférer simultanément de multiples fonctionnalités à des vecteurs nanoparticulaires polymères représente un objectif pharmacotechnique majeur dans le domaine de la vectorisation. Dans ce travail de recherche, quatre dérivés du poly (L-glutamate de γ-benzyle) possédant chacun une fonctionnalité spécifique ont été synthétisés par polymérisation anionique d'ouverture du cycle du γ-BLG-NCA: le poly(L-glutamate de γ-benzyle)-cyclodextrine, le poly(L-glutamate de γ--benzyle)-benzylamine, le poly (L-glutamate de γ-benzyle)-poly(éthylène glycol) et le poly (L-glutamate de γ-benzyle)-biotine. Les prop

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3

Taylor, castillo An Young. "Nanoparticules à base de poly(L-glutamate de γ-benzyle) pour l’interception et la destruction des cellules tumorales circulantes dans la circulation sanguine". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS245.

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En dépit de progrès considérables, le cancer reste l'une des principales causes de morbidité et de mortalité dans le monde. Actuellement, 90% des décès liés au cancer sont causés par la propagation de cellules cancéreuses vers des organes distants. Une fois implantées et disséminées, les métastases sont beaucoup plus difficiles à détruire par les moyens de la chimiothérapie.A la suite d’un processus d’intravasation, certaines cellules tumorales s’échappent de la tumeur primaire et empruntent les systèmes circulatoires avant d’être ensuite extravasées, puis distribuées et finalement disséminées

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4

Segura, Sanchez Freimar. "Nanoparticules multifonctionnelles de poly (L-glutamate de γ-benzyle) conçues pour être aisément décorées par des ligands de reconnaissance par la mise en oeuvre du système biotine-avidine". Paris 11, 2009. http://www.theses.fr/2009PA114827.

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Une mini famille constituée de copolymères possédant en commun un bloc poly (L-glutamate de γ-benzyle) hydrophobe mais portant chacun diverses fonctionnalités utiles à la vectorisation a été synthétisée. La capacité de ces copolymères à s'auto assembler et former des nanoparticules et à s'auto associer et conférer simultanément différentes fonctionnalités aux nanoparticules a été établie par les techniques de la physico-chimie. De plus, afin de pouvoir introduire des ligands de reconnaissance à la surface des particules, il a été fait appel au système biotine-avidine et l'efficacité de la bion

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5

Miguel, Martínez de Aragón Laura de. "Nanoparticules multifonctionnelles de PBLG destinées au ciblage et à la délivrance d’anticancéreux aux tissus osseux." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114829/document.

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Des nanoparticules multifonctionnelles polymères, préparées par auto-assemblage de plusieurs dérivés du poly (L-glutamate de gamma-benzyle) (PBLG), ont été conçues afin d’assurer le ciblage des tissus osseux et la libération contrôlée de molécules actives. Des propriétés d'attachement aux tissus osseux leur ont été conférées par la présentation en surface de différents ligands ostéotropes, l'alendronate et l' acide poly(glutamique), seuls ou en combinaison. Leur affinité pour les tissus osseux a été évaluée in vivo ainsi que leur distribution fine dans ces tissus. Par ailleurs, des propriétés

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6

Niehoff, Ansgar [Verfasser], and H. [Akademischer Betreuer] Menzel. "Funktionalisiertes Poly(gamma-benzyl-L-glutamat) als vielseitige Plattform für Stäbchen-Knäuel-Blockcopolymere und thermoreversible Gele / Ansgar Niehoff ; Betreuer: H. Menzel." Braunschweig : Technische Universität Braunschweig, 2012. http://d-nb.info/1175824054/34.

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7

Stern, Maria [Verfasser], and Henning [Akademischer Betreuer] Menzel. "Synthese und Charakterisierung von speziellen makromolekularen Architekturen basierend auf Poly(gamma-benzyl-L-glutamat) als stäbchenförmiges Modellpolymer / Maria Stern ; Betreuer: Henning Menzel." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175822353/34.

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8

Thorpe, Sandra Denise. "Preparation and characterization of sodium poly(aL-glutamate)/poly(pyrrole)/poly(ethylene oxide) polymeric blends for a responsive peptide drug delivery system." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2004. http://digitalcommons.auctr.edu/dissertations/1703.

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Blends of sodium poly(a,L-glutamate) (MW 49K), poly(pyrrole) and poly(ethylene oxide) (MW lOOK) were prepared by a solution-blending process. A series of blend compositions were studied and characterized to determine optimal parameters and conditions necessary for the encapsulation and stability of the peptide portion of this ternary system. The retaining of the conformational structure of the peptide is important for its activity in a delivery system. Results derived from Infrared Spectroscopy (lR) indicated that the helical conformation of the peptide was maintained. The solid-state morpholo

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9

Crespo, Janaina da Silva. "Estudo da estrutura e dinâmica de copolímeros em bloco poli(estireno)-b-poli(y-benzil-L-glutamato) por espalhamento de luz e de nêutrons." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/86204.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Quimica.<br>Made available in DSpace on 2012-10-21T04:41:04Z (GMT). No. of bitstreams: 0<br>Neste trabalho, foi realizada a síntese e a caracterização de copolímeros dibloco do tipo flexível-rígido formados pelo poli(estireno)-b-poli(g-benzil-L-glutamato) (PS-b-PBLG). A parte flexível foi constituída pelo PS, e a parte rígida pelo peptídio PBLG. Esse peptídeo apresenta uma estrutura secundária de a-hélice, que garante a rigidez desse bloco. O bloco de PS foi sinteti

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10

Denker, Elsa. "Développement et évolution des cellules neurosensorielles chez les cnidaires : apports de l’étude de la nématogenèse de la méduse de Clytia hemisphaerica." Paris 6, 2008. http://www.theses.fr/2008PA066034.

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Les cnidaires sont un groupe-clé pour étudier l’origine et l’évolution des cellules nerveuses. Des marqueurs neuronaux de Bilateria sont exprimés dans le bulbe tentaculaire de la méduse de Clytia hemisphaerica, spécialisé dans la production massive de cellules neurosensorielles, les nématocytes. La dynamique de la nématogenèse du bulbe a été étudiée ; les stades de différenciation y sont répartis selon un gradient proximo-distal, corrélé à un étagement de profils d’expression de gènes. La capacité d’autonomie du bulbe in vitro en fera un modèle expérimental performant pour réaliser des études

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11

Casajus, Hubert. "Étude de la polymérisation enzymatique de la malolactonates en présence de lipases." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S090/document.

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Les polyesters aliphatiques, comme le poly(acide malique) et ses dérivés, sont une famille de polymères aux propriétés de bio(comptabilité) et de bio(dégradabilité) remarquables, qui en font des candidats de choix pour l'élaboration de systèmes de vectorisation de principes actifs. Généralement, ces polymères sont synthétisés via des réactions de polymérisation utilisant des amorceurs, voir des catalyseurs, organiques, organométalliques ou métalliques. La présence de ces molécules, même à l'état de traces, peut être à l'origine d'une toxicité non souhaitée. Par conséquent, l'utilisation de bio

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12

Whitton, Gregory. "Synthesis of Arborescent Copolymers Based on Poly(γ-benzyl L-glutamate)". Thesis, 2013. http://hdl.handle.net/10012/7469.

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The synthesis of arborescent poly(gamma-benzyl L-glutamate) (PBG) molecules was achieved through successive grafting reactions of linear PBG chains. These linear PBG building blocks were obtained by the ring-opening polymerization of gamma-benzyl L-glutamic acid N-carboxyanhydride initiated with n-hexylamine. Cleavage of a fraction of the benzyl ester groups on a linear PBG substrate, followed by coupling with linear PBG side chains via standard peptide coupling techniques, yielded a comb-branched or generation zero (G0) arborescent PBG. Further cycles of partial deprotection and grafting reac

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13

Soto, Carissa M. "Monodisperse benzyl -ester derivatives of poly(α, L-glutamate) and poly(α, L-aspartate) modeling nature's delicate state of matter". 2000. https://scholarworks.umass.edu/dissertations/AAI9960791.

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Biosynthesis of monodisperse poly(α,L-aspartic acid) and optimization of poly(α,L-glutamic acid) production have been accomplished. Protein design having as ultimate goal the synthesis of monodisperse benzyl-ester derivatives of α-helical polypeptides by genetic engineering has been performed. This comprises design of a monomeric DNA cassette, cloning, multimerization, ligation into an expression vector, and expression of the target gene followed by purification of the resultant protein. Advantages of such techniques include control of molecular size, composition, sequence and stereochemistry

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14

Li, Shu-ting, та 李書廷. "Aggregation induced emission enhancement in relation to the secondary structures of poly(γ-benzyl-L-glutamate) containing fluorescent tetraphenylthiophene moiety". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/52579614275986135825.

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碩士<br>國立中山大學<br>材料與光電科學學系研究所<br>100<br>In this study, tetraphenylthiophenen (TP) with aggregation-induced emission enhancement (AIEE) property is served as terminal and central fluorophores of poly(γ-benzyl-L-glutamate) (PBLG)-based polymers of TP1PBLG and TP2PBLG, respectively, to probe for the relationship between the secondary structure (α-helix) of polypeptides and the ALEE-operative fluorescence (FL). Intermolecular aggregation of the central TP unit in the di-substituted TP2PBLG is sterically blocked by the large α-helical PBLG chains, which lead to the reduced AIEE-oriented FL. On the c

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15

Yu, Michael Seungju. "Smectic ordering of rod-like polymers owing to monodispersity of chain length: Synthesis and characterization of benzyl and (4-hexadecyloxy)benzyl esters of monodisperse derivatives of poly(alpha,L-glutamate)." 1998. https://scholarworks.umass.edu/dissertations/AAI9909234.

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Two types of monodisperse rod-like polymers, poly($\gamma$-benzyl $\alpha$,L-glutamate) (PBLG) and poly($\gamma$-4-(hexadecyloxy)benzyl $\alpha$,L-glutamate) with backbone sequences of have been prepared by chemical modification of monodisperse poly($\alpha$,L-glutamic acid) (PLGA) that was synthesized by recombinant DNA biosynthesis techniques. The monodisperse PLGA () was produced in Escherichia coli as a fusion to mouse dihydrofolate reductase and purified to homogeneity by metal affinity chromatography, CNBr digestion and ion-exchange chromatography.$$\rm GluAsp(Glu\sb{17}Asp)\sb{x}GluGlu\

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16

Hsu, Chih-Ching, та 許芝菁. "Phase Behavior of Poly(γ-alkyl-L-glutamate)s". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/23811097999412466892.

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碩士<br>國立中山大學<br>材料科學研究所<br>90<br>Thermal behavior and molecular packing of a series of α-helical poly(L-glutamates), with n-alkyl side chain of various lengths (m(number of carbons in the alkyl group) = 1, 2, 6, 12,18), were studied by means of differential scanning calorimetry, polarizing light microscopy and X-ray diffraction. For polymers of m = 1 and 2, There is a pseudohexagonal structure below ca. 130 oC and above this temperature the stable phase is the hexagonal columnar phase. There exists a layered structure in the polymer of m = 6, as well as a solvent induced hexagonal columnar s

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17

Guan-JhongDing та 丁冠中. "Preparation and characterization of waterbased poly(urethane) / poly(γ-glutamate) / tricalcium phosphate composite scaffolds". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75139432402043325729.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>98<br>Novel porous composite scaffolds for bone tissue engineering were prepared from water-based polyurethane (WPU), tricalcium phosphate (TCP) and poly(γ-glutamate) (γ-PGA). γ-PGA modified commercially available pellethane exhibit a smaller contact angle, and higher water absorption value than the pellethane without γ-PGA. In vitro platelet adhesion studies indicated that the addition of γ-PGA into pellethane leads to a reduction in platelet adhesion and activation. Results indicated that NCO/OH=1.8 and DMPA=6wt% of water-based polyurethane(WPU) had superior ten

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18

Tseng, Wei-Yu, та 曾偉雨. "Adsorption of copper ions by poly-γ-glutamate-formed apatites". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/56237907903213268210.

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碩士<br>國立雲林科技大學<br>化學工程與材料工程系碩士班<br>100<br>In this study, poly-γ-glutamate-apatite (PGA-AP) particles were prepared for the adsorption of copper ions. They were synthesized by coprecipitation between calcium nitrate and diammonium phosphate in poly-γ-glutamate (PGA) solution with different feed ratios of PGA to calcium nitrate and diammonium phosphate. The theoretical weight ratios of poly γ-glutamate to apatite (PGA/AP) for PGA-AP particles are 1:20 (G1H20), 1:40 (G1H40) and 1:60 (G1H60). The PGA-AP particles were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffracto

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19

Lee, Tsung-Han, and 李宗翰. "Preparation and characterization of cross-linked gamma-poly glutamate/gelatin hydrogel." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/hmh62p.

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碩士<br>國立臺北科技大學<br>化學工程研究所<br>101<br>The healing of wounds on skin is accelerated under a proper humid environment than a dry one. Nevertheless, immoderate free radicals will lead to excessive inflammation reactions and retard the healing processes. The motivation of this study is to prepare a cross-linked composite hydrogel with combining the advantages of gelation gelatin, humidifying γ-poly glutamate (γ-PGA) and antioxidative proanthocyanidins (OPCs). The natural polymer made hydrogel is proposed to be applied as a wound dressing. In this research, the hydrogel wound dressing was prepared by

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20

Jie, Liao Shi, та 廖士傑. "Developement of γ-Poly-Glutamate Copper and the Relative Bioavailability in Chicks". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/29684112096101786449.

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碩士<br>國立嘉義大學<br>動物科學系研究所<br>99<br>The purpose of this study is to develop the organic γ-poly-glutamate -copper compound (γ-PGA-Cu) by chelating γ-poly-glutamic acid (γ-PGA) with Cu(II) ion and compare the relative bioavailability with copper sulfate (CuSO4‧5H2O), commercial organic copper (Bioplex® Cu) and microbial copper (Micro-Cu) in chickens. Different concentration of Cu(II) ion (10 mM, 20 mM, 50mM, 100mM and 200mM) was added into a γ-PGA solution (12.5 μM) to form different ratio of γ-PGA-Cu compounds to estimate the binding capability of γ-PGA with Cu2+. The ratio of binding Cu2+ in γ-P

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21

Wu, Hui-Chun, та 吳蕙均. "Characteristics of poly (γ-methyl l-glutamate)/poly (vinylidene fluoride) piezoelectric fiber composites via near-field electrospinning process". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/e3ms36.

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碩士<br>國立中山大學<br>機械與機電工程學系研究所<br>102<br>In this study, the technology of near-field electrospinning (NFES) is developed to collect orderly poly (γ-methyl L –glutamate) (PMLG)/poly (vinylidene fluoride) (PVDF) fiber composites with enhanced piezoelectricity. PMLG solution was blended with PVDF solution uniformly to prepare PMLG/PVDF solution (30.68 wt%). When the droplet of polymer blend overcame the surface tension of PMLG/PVDF solution to form Taylor cone at high electric field of 1×107-1.6×107 V/m, a PMLG/PVDF piezoelectric fiber (diameter=17.25-7.62 µm) was spun from the tip of Taylor cone a

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22

Chen, Chien-Lin, та 陳建霖. "Preparation and characterization ofpoly-γ-glutamate-formed hydroxyapatite/waterbased poly(urethane) composite scaffolds". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/13402203497680041957.

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碩士<br>國立雲林科技大學<br>化學工程與材料工程研究所<br>99<br>In this study, poly-γ-glutamate-hydroxyapatite (PGA-HA) particles were synthesized by a co-precipitation method. Then, a series of PGA-HA/water-based polyurethane composite films and scaffolds with different amounts of PGA-HA particles were fabricated. The content of PGA-HA in the composite films and scaffolds was 0~43 wt% and 0~67 wt%, respectively. The results of wide-angle X-ray diffraction and energy dispersive X-ray spectroscopy (EDS) confirmed that the synthesized calcium phosphate was in the form of HA with the ratio of Ca/P = 1.67. The particle s

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23

Chia-SuiChen та 陳佳穗. "Poly-γ-glutamate Microneedles for Treatment of Atopic Dermatitis-like Skin Lesion in Nc/Nga mice". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/2r972u.

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24

Man-ChunChuang and 莊曼君. "Delivery of antigen-loaded chitosan/hyaluronic acid nanoparticles using poly-gamma-glutamate microneedles for transcutaneous immunization." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/we3qd6.

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Ciou, Fong-Yi, та 邱鳳逸. "Study of polypeptide poly (γ-methyl l-glutamate) by near-fieldelectrospinning and electrospray technology for cell proliferation". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/5emtp9.

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碩士<br>國立中山大學<br>機械與機電工程學系研究所<br>103<br>The formation and application of fibers and films based on the near-field electrospinning (NFES) and electrospray (ESP) technology are investigated in this research. The poly [ (γ-methyl l-glutamate) , PMLG] was used as based material and then the Poly [ (ethylene oxide), PEO] and surfactant were mixed with PMLG to fabricate PMLG solution with 21.05 wt% concentration. Next, with the NFES and ESP processes, the high voltage electric field and numerical control (NC) controller (movement speed: 60 mm/sec, path spacing: 250, 500, 750 μm) were controlled to ma

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