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Journal articles on the topic 'Poly-ic'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Packard, Amy E. B., Jason C. Hedges, Frances R. Bahjat, et al. "Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury." Journal of Cerebral Blood Flow & Metabolism 32, no. 2 (2011): 242–47. http://dx.doi.org/10.1038/jcbfm.2011.160.

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Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is

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2

Lee, Li-Ting, Sheng-Ping He, and Chih-Feng Huang. "Enhancement of Crystallization Behaviors in Quaternary Composites Containing Biodegradable Polymer by Supramolecular Inclusion Complex." Crystals 10, no. 12 (2020): 1137. http://dx.doi.org/10.3390/cryst10121137.

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Novel multi-component composites composed of the biodegradable polymer poly(ethylene adipate) (PEA), the water-soluble polymer poly(ethylene oxide) (PEO), poly(vinyl acetate) (PVAc), and a supramolecular-like inclusion complex (IC) made by α-cyclodextrin (α-CD) and poly(ε-caprolactone) (PCL) (coded as PCL–CD–IC) are discussed in this work. The PCL–CD–IC was used to increase the crystallization rate of the miscible PEA/PEO/PVAc ternary blend that crystalized slower than neat PEA. Higher resolution SEM and TEM images displayed that PCL–CD–IC did not assemble notably in the quaternary composites.

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3

Lauterbach, Henning, Barbara Bathke, Stefanie Gilles та ін. "Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC". Journal of Experimental Medicine 207, № 12 (2010): 2703–17. http://dx.doi.org/10.1084/jem.20092720.

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Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-λ, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation factor 88), Rig-like helicases, or lymphocytes. Upon poly IC injection in vivo, the IFN-λ production by

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Luo, Xuelian, Dawei Ling, Ting Li, Chao Wan, Chuyu Zhang та Zishu Pan. "Classical swine fever virus Ernsglycoprotein antagonizes induction of interferon-β by double-stranded RNA". Canadian Journal of Microbiology 55, № 6 (2009): 698–704. http://dx.doi.org/10.1139/w09-013.

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Classical swine fever virus (CSFV) is capable of counteracting innate cellular antiviral responses by inhibiting type I interferon (IFN)-α/β induction. A function associated with CSFV Npro, with respect to the inhibition of IFN-β production, has been clearly elucidated. In this study, we explored the role of CSFV Ernsin IFN-β induction by exogenous double-stranded (ds) RNA. Synthetic dsRNA (poly (IC)) was used as an exogenous stimulus to trigger IFN-β induction. CSFV Ernsinhibited IFN-β promoter-driven luciferase activity induced by poly (IC) in different cell lines, and the inhibitory effect

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5

Padalko, Elizaveta, Dieter Nuyens, Armando De Palma, et al. "The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis." Antimicrobial Agents and Chemotherapy 48, no. 1 (2004): 267–74. http://dx.doi.org/10.1128/aac.48.1.267-274.2004.

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ABSTRACT Viral replication, as well as an immunopathological component, is assumed to be involved in coxsackie B virus-induced myocarditis. We evaluated the efficacy of the interferon inducer Ampligen on coxsackie B3 virus-induced myocarditis in C3H/HeNHsd mice. The efficacy of Ampligen was compared with that of the interferon inducer poly(inosinic acid)-poly(cytidylic acid) [poly(IC)], alpha interferon 2b (INTRON A), and pegylated alpha interferon 2b (PEG-INTRON-α-2b). Ampligen at 20 mg/kg of body weight/day was able to reduce the severity of virus-induced myocarditis, as assessed by morphome

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6

Ruggli, Nicolas, Jon-Duri Tratschin, Matthias Schweizer, Kenneth C. McCullough, Martin A. Hofmann, and Artur Summerfield. "Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro." Journal of Virology 77, no. 13 (2003): 7645–54. http://dx.doi.org/10.1128/jvi.77.13.7645-7654.2003.

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ABSTRACT Classical swine fever virus (CSFV) replicates efficiently in cell lines and monocytic cells, including macrophages (MΦ), without causing a cytopathic effect or inducing interferon (IFN) secretion. In the present study, the capacity of CSFV to interfere with cellular antiviral activity was investigated. When the porcine kidney cell line SK-6 was infected with CSFV, there was a 100-fold increased capacity to resist to apoptosis induced by polyinosinic-polycytidylic acid [poly(IC)], a synthetic double-stranded RNA. In MΦ, the virus infection inhibited poly(IC)-induced alpha/beta IFN (typ

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7

Martins, Karen AO, Sina Bavari, and Andres M. Salazar. "Vaccine adjuvant uses of poly-IC and derivatives." Expert Review of Vaccines 14, no. 3 (2014): 447–59. http://dx.doi.org/10.1586/14760584.2015.966085.

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8

Longhi, M. Paula, Christine Trumpfheller, Juliana Idoyaga, et al. "Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant." Journal of Experimental Medicine 206, no. 7 (2009): 1589–602. http://dx.doi.org/10.1084/jem.20090247.

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Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4+ T cell responses to a dendritic cell (DC)–targeted HIV gag protein vaccine in mice. To identify mechanisms for adjuvant action in the intact animal and the polyclonal T cell repertoire, we found poly IC to be the most effective inducer of type I interferon (IFN), which was produced by DEC-205+ DCs, monocytes, and stromal cells. Antibody blocking or deletion of type I IFN receptor showed that IFN was essential for DC maturation and develo

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9

Stevenson, H. C., G. A. Dekaban, P. J. Miller, C. Benyajati, and M. L. Pearson. "Analysis of human blood monocyte activation at the level of gene expression. Expression of alpha interferon genes during activation of human monocytes by poly IC/LC and muramyl dipeptide." Journal of Experimental Medicine 161, no. 3 (1985): 503–13. http://dx.doi.org/10.1084/jem.161.3.503.

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Human monocytes were activated to secrete alpha interferon (IFN-alpha) by poly IC/LC but not by other monocyte activators, such as muramyl dipeptide (MDP). In contrast, monocytes were activated to secrete fibroblast growth factor (FGF) release by MDP but not by poly IC/LC. The amount of total RNA present in unactivated and activated human monocytes was similar. Using two 32P-labeled cDNA probes (pLM001 and HuIFN-alpha 2) for human IFN-alpha genes in hybridization studies, we analyzed messenger RNA species from this gene family in activated human monocytes. After activation with poly IC/LC, two

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10

Caskey, Marina, François Lefebvre, Abdelali Filali-Mouhim, et al. "Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans." Journal of Experimental Medicine 208, no. 12 (2011): 2357–66. http://dx.doi.org/10.1084/jem.20111171.

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Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized with poly-l-lysine [poly ICLC]), an agonist for toll-like receptor (TLR) 3, and the cytosolic RNA helicase MDA-5. Transcriptional analysis of blood samples from eight volunteers, after subcutaneous administration of poly

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11

Koizumi, A., L. Hasegawa, K. E. Rodgers, D. Ellefson, R. L. Walford, and T. Imamura. "Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities." Biochemical and Biophysical Research Communications 138, no. 1 (1986): 246–53. http://dx.doi.org/10.1016/0006-291x(86)90272-x.

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12

Liu, Qiang, Tadaatsu Imaizumi, Tomomi Aizawa, et al. "Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells." Kidney and Blood Pressure Research 44, no. 1 (2019): 62–71. http://dx.doi.org/10.1159/000498837.

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Background/Aims: Dysregulation of interleukin-6 (IL-6) production in residual renal cells may play a pivotal role in the development of glomerulonephritis (GN). Given that Toll-like receptor 3 (TLR3) signaling has been implicated in the pathogenesis of some forms of GN, we examined activated TLR3-mediated IL-6 signaling in cultured normal human glomerular endothelial cells (GECs). Methods: We treated GECs with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, and analyzed the expression of IL-6 and the cytosolic viral RNA sensors retinoic acid-inducible gene-I (RIG-I

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13

Khan, I., G. G. Spencer, S. E. Samson, P. Crine, G. Boileau, and A. K. Grover. "Abundance of sarcoplasmic reticulum calcium pump isoforms in stomach and cardiac muscles." Biochemical Journal 268, no. 2 (1990): 415–19. http://dx.doi.org/10.1042/bj2680415.

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Rabbit stomach smooth muscle contains mRNA for an internal Ca2+ pump identical in sequence to that reported for rabbit uterus [Lytton, Zarain-Herzberg, Periasamy & MacLennan (198) J. Biol. Chem. 264, 7059-7065]. This is an alternatively spliced form (Is) of the cardiac muscle sarcoplasmic reticulum Ca2+ pump (Ic). The splicing results in replacement of the last 4 amino acids (Ala-Ile-Leu-Glu) present in Ic by 49 amino acids and by a different 3′-non-coding region. Using cDNA probes against the conserved and the alternatively spliced regions, we determined that poly(A+) RNA isolated from ra

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14

Komal, Asma, Mamoona Noreen, and Attalla F. El-Kott. "TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review." Immunologic Research 69, no. 4 (2021): 312–22. http://dx.doi.org/10.1007/s12026-021-09203-6.

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15

Umetsu, Hidenori, Shojiro Watanabe, Tadaatsu Imaizumi, et al. "Interleukin-6 via Toll-Like Receptor 3 Signaling Attenuates the Expression of Proinflammatory Chemokines in Human Podocytes." Kidney and Blood Pressure Research 46, no. 2 (2021): 207–18. http://dx.doi.org/10.1159/000514589.

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<b><i>Background:</i></b> Although toll-like receptor 3 (TLR3) signaling is involved in the development of certain chronic kidney diseases, the specific molecular mechanisms underlying inflammatory reactions via activation of TLR3 signaling in human podocytes remain unclear. Interleukin (IL)-6 is a pleiotropic cytokine associated with innate and adaptive immune responses; however, little is known about the implication of IL-6 via the activation of regional TLR3 signaling in the inflammatory reactions in human podocytes. <b><i>Methods:</i></b> We

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16

Xu, Xiao-bo, Qing Li, and Cheng-dong Xiong. "Crystallization behavior of poly(p-dioxanone) with cyclodextrin complex and nucleation mechanism discussion." RSC Advances 6, no. 90 (2016): 87169–78. http://dx.doi.org/10.1039/c6ra18845a.

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In the interest of improving the crystallization rate of poly(p-dioxanone) (PPDO), an inclusion complex (IC) based on β-cyclodextrin (β-CD) and polyglycolide (PGA) serving as a green nucleating agent for PPDO was achieved by a solution technique.

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17

Natarajan, Chandramohan, Song-Yi Yao, and Subramaniam Sriram. "TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair." PLOS ONE 11, no. 3 (2016): e0152163. http://dx.doi.org/10.1371/journal.pone.0152163.

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18

Schweizer, Matthias, and Ernst Peterhans. "Noncytopathic Bovine Viral Diarrhea Virus Inhibits Double-Stranded RNA-Induced Apoptosis and Interferon Synthesis." Journal of Virology 75, no. 10 (2001): 4692–98. http://dx.doi.org/10.1128/jvi.75.10.4692-4698.2001.

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ABSTRACT Bovine viral diarrhea virus (BVDV), a pestivirus of theFlaviviridae family, is an economically important cattle pathogen with a worldwide distribution. Both noncytopathic (ncp) and cytopathic (cp) biotypes of BVDV can be isolated from persistently infected cattle suffering from the lethal mucosal disease. The cp biotype correlates with the production of the NS3 nonstructural protein, which in the corresponding ncp biotype is present in its uncleaved form, NS23. Previously, we have shown that cp but not ncp BVDV induces the formation of α/β interferons in bovine macrophages. In this st

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19

Zhong, Jian, and John M. Kyriakis. "Germinal Center Kinase Is Required for Optimal Jun N-Terminal Kinase Activation by Toll-Like Receptor Agonists and Is Regulated by the Ubiquitin Proteasome System and Agonist-Induced, TRAF6-Dependent Stabilization." Molecular and Cellular Biology 24, no. 20 (2004): 9165–75. http://dx.doi.org/10.1128/mcb.24.20.9165-9175.2004.

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ABSTRACT Germinal center kinase (GCK), a member of the Ste20 family, selectively activates the Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases. Here, we show that endogenous GCK is activated by polyinosine-polycytidine [poly(IC)] and lipopolysaccharides (LPS), lipid A, interleukin-1 (IL-1), and engagement of CD40, all agonists that require TRAF6 for JNK activation. RNA interference experiments indicate that GCK is required for the maximal activation of JNK by LPS, lipid A, poly(IC), and, to a lesser extent, IL-1 and engagement of CD40. GCK is ubiquitinated in situ and st

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20

Matsudai, Tomoko, Mamoru Terauchi, Makoto Yoshimi, Norio Yasuhara, Yukihiro Ushiku, and Akio Nakagawa. "Evaluation of 0.3µm Poly-Silicon CMOS Circuits for Intelligent Power IC Application." Japanese Journal of Applied Physics 37, Part 1, No. 3B (1998): 1103–6. http://dx.doi.org/10.1143/jjap.37.1103.

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21

ZHOU, Q., E. CHEN, L. CHEN, et al. "Sensitivity of drug-resistant mutants of hepatitis B virus to poly-IC." Acta virologica 58, no. 04 (2014): 348–55. http://dx.doi.org/10.4149/av_2014_04_348.

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22

Ali, B., R. L. Walford, and T. Imamura. "Influence of aging and poly IC treatment on xenobiolic metabolism in mice." Life Sciences 37, no. 15 (1985): 1387–93. http://dx.doi.org/10.1016/0024-3205(85)90077-3.

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23

Hewson, Christopher A., Alice Jardine, Michael R. Edwards, Vasile Laza-Stanca, and Sebastian L. Johnston. "Toll-Like Receptor 3 Is Induced by and Mediates Antiviral Activity against Rhinovirus Infection of Human Bronchial Epithelial Cells." Journal of Virology 79, no. 19 (2005): 12273–79. http://dx.doi.org/10.1128/jvi.79.19.12273-12279.2005.

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ABSTRACT Rhinoviruses (RV) are the major cause of the common cold and acute exacerbations of asthma and chronic obstructive pulmonary disease. Toll-like receptors (TLRs) are a conserved family of receptors that recognize and respond to a variety of pathogen-associated molecular patterns. TLR3 recognizes double-stranded RNA, an important intermediate of many viral life cycles (including RV). The importance of TLR3 in host responses to virus infection is not known. Using BEAS-2B (a human bronchial epithelial cell-line), we demonstrated that RV replication increased the expression of TLR3 mRNA an

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Sava, I., B. Schulz, S. Zhu, and M. Bruma. "Synthesis and characterization of new silicon-containing poly(arylene-1,3,4-oxadiazole)s." High Performance Polymers 7, no. 4 (1995): 493–501. http://dx.doi.org/10.1088/0954-0083/7/4/011.

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New silicon-containing aromatic polyhydrazides were synthesized by low-temperature solution polycondensation reaction of bis(p-chlorocarbonylphenyl)diphenylsilane with various aromatic dihydrazides, or of bis(p-carbohydrazidophenyl)diphenylsilane with diacid chlorides. The corresponding poly(arylene-1,3,4-oxadiazole)s wvere prepared by thermal cyclodehydration in the solid state. The cyclization process takes place at temperatures in the range of 250-300 IC. The resulting silicon-containing poly(arylene-1,3,4-oxadiazole)s are soluble in common organic solvents and have good film-forming abilit

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Aurilio, Gaetano, Alessia Cimadamore, Matteo Santoni, et al. "New Frontiers in Prostate Cancer Treatment: Are We Ready for Drug Combinations with Novel Agents?" Cells 9, no. 6 (2020): 1522. http://dx.doi.org/10.3390/cells9061522.

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Medical treatment for metastatic castration-resistant prostate cancer (mCRPC) patients has progressively been evolving from a nonspecific clinical approach to genomics-oriented therapies. The scientific community is in fact increasingly focusing on developing DNA damage repair (DDR) defect-driven novel molecules, both as single-agent therapy and in combined treatment strategies. Accordingly, research is under way into combined drug therapies targeting different pathways, e.g. androgen receptor signaling (ARS) and poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) enzymes, immune check

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26

Hori, A. "Poly IC evokes fever through induction of cyclooxygenase-2 in brain endothelial cells." Neuroscience Research 38 (2000): S167. http://dx.doi.org/10.1016/s0168-0102(00)81848-9.

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27

Rydberg, M., and U. Smith. "Long-term stability and electrical properties of compensation doped poly-Si IC-resistors." IEEE Transactions on Electron Devices 47, no. 2 (2000): 417–26. http://dx.doi.org/10.1109/16.822289.

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28

Naviaux, Robert K., Zarazuela Zolkipli, Lin Wang, et al. "Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model." PLoS ONE 8, no. 3 (2013): e57380. http://dx.doi.org/10.1371/journal.pone.0057380.

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29

Arribillaga, Laura, Iciar Echeverria, Viriginia Belsue, et al. "Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens." Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000704. http://dx.doi.org/10.1136/jitc-2020-000704.

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BackgroundIn vivo targeting of human papillomavirus (HPV) derived antigens to dendritic cells might constitute an efficient immunotherapeutic strategy against cervical cancer. In previous works, we have shown that the extra domain A from murine fibronectin (mEDA) can be used to target antigens to toll-like receptor 4 (TLR4) expressing dendritic cells and induce strong antigen-specific immune responses. In the present study, we have produced a bivalent therapeutic vaccine candidate consisting of the human EDA (hEDA) fused to E7 proteins from HPV16 and HPV18 (hEDA-HPVE7-16/18) and evaluate its p

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Zhang, Li, Weijun Zhen та Yufang Zhou. "Structure and properties of poly(lactic acid)/poly(lactic acid)-α-cyclodextrin inclusion compound composites". Journal of Polymer Engineering 37, № 9 (2017): 897–909. http://dx.doi.org/10.1515/polyeng-2016-0088.

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Abstract Poly(lactic acid) (PLA) was synthesized using a green catalyst, nano-zinc oxide (ZnO). The optimum synthesis conditions of PLA were as follows: a stoichiometric amount of 0.5 wt% of nano-ZnO, polymerization time of 14 h, and polymerization temperature of 170°C. Gel permeation chromatography results showed that the weight-average molecular weight (Mw) of PLA was 13,072 g/mol with a polydispersity index (PDI) of 1.7. Furthermore, PLA-α-cyclodextrin inclusion compounds (PLA-CD-ICs) were prepared by ultrasonic co-precipitation techniques. X-ray diffraction analysis and Fourier transform i

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Sultan, Hussein, Juan Wu, Valentyna I. Fesenkova, et al. "Poly-IC enhances the effectiveness of cancer immunotherapy by promoting T cell tumor infiltration." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e001224. http://dx.doi.org/10.1136/jitc-2020-001224.

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BackgroundImmunotherapies, such as immune checkpoint inhibitors and adoptive cell therapies, have revolutionized cancer treatment and resulted in complete and durable responses in some patients. Unfortunately, most immunotherapy treated patients still fail to respond. Absence of T cell infiltration to the tumor site is one of the major obstacles limiting immunotherapy efficacy against solid tumors. Thus, the development of strategies that enhance T cell infiltration and broaden the antitumor efficacy of immunotherapies is greatly needed.MethodsWe used mouse tumor models, genetically deficient

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Gouda, MH, Abdelaziz H. Konsowa, Hassan A. Farag, Noha A. Elessawy, Tamer M. Tamer, and Mohamed S. Mohy Eldin. "Novel nanocomposite membranes based on cross-linked eco-friendly polymers doped with sulfated titania nanotubes for direct methanol fuel cell application." Nanomaterials and Nanotechnology 10 (January 1, 2020): 184798042096436. http://dx.doi.org/10.1177/1847980420964368.

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Developing low cost and highly active fuel cell is one of the high-priority research directions for fuel cell commercialization, whereas durable electrodes and electrolyte membranes are keys for its optimization. Herein, a novel nanocomposite electrolyte membranes for direct methanol fuel cell were prepared from eco-friendly polymer blend composed of poly(vinyl alcohol) (PVA) and iota carrageenan (IC). Sulfated titania (SO4TiO2) nanotubes are synthesized by impregnation–calcination method and incorporated as doping agents into the polymer matrix with different percentage ranged between 1 wt% a

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Zhao, Yunying, Zheng He, Qiang Zhang, et al. "880 nm NIR-Triggered Organic Small Molecular-Based Nanoparticles for Photothermal Therapy of Tumor." Nanomaterials 11, no. 3 (2021): 773. http://dx.doi.org/10.3390/nano11030773.

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Photothermal therapy (PTT) has received constant attention as an efficient cancer therapy method due to locally selective treatment, which is not affected by the tumor microenvironment. In this study, a novel 880 nm near-infrared (NIR) laser-triggered photothermal agent (PTA), 3TT-IC-4Cl, was used for PTT of a tumor in deep tissue. Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (β-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothe

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Wang, Yan, Jia Yuan, Dongfang Dai, et al. "Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1." Acta Biochimica et Biophysica Sinica 50, no. 9 (2018): 862–68. http://dx.doi.org/10.1093/abbs/gmy082.

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Tang, Siqi, Jiang Yan, Jing Zhang, et al. "Fabrication of Low Cost and Low Temperature Poly-Silicon Nanowire Sensor Arrays for Monolithic Three-Dimensional Integrated Circuits Applications." Nanomaterials 10, no. 12 (2020): 2488. http://dx.doi.org/10.3390/nano10122488.

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In this paper, the poly-Si nanowire (NW) field-effect transistor (FET) sensor arrays were fabricated by adopting low-temperature annealing (600 °C/30 s) and feasible spacer image transfer (SIT) processes for future monolithic three-dimensional integrated circuits (3D-ICs) applications. Compared with other fabrication methods of poly-Si NW sensors, the SIT process exhibits the characteristics of highly uniform poly-Si NW arrays with well-controlled morphology (about 25 nm in width and 35 nm in length). Conventional metal silicide and implantation techniques were introduced to reduce the parasit

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Lewis, Nathan, Krishna Shenai, and Ernest L. Hall. "TEM analysis of TiSi2 on Si and polysilicon." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 886–87. http://dx.doi.org/10.1017/s0424820100106491.

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TiSi2, when deposited on poly-Si and Si, exhibits very low sheet resistance ana can be easily integrated into existing device and IC fabrication environments. However, the high temperature process stability of TiSi2 is rather limited. The silicide must be able to withstand processing temperatures in the 800°C-1000°C range for the fabrication of many high voltage devices and integrated circuits. In the present investigation the high temperature stability of the TiSi2 structures were examined using TEH on both planar and cross-sectional specimens.The starting materials in this study were <100

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Li, Shun, Qi Jun Yu, Jiang Xiong Wei, and Zi Yun Wen. "Synthesis and Dispersibility of Polycarboxylate Copolymers with Poly(ethylene oxide) Side Chain." Advanced Materials Research 250-253 (May 2011): 401–4. http://dx.doi.org/10.4028/www.scientific.net/amr.250-253.401.

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Polycarboxylate copolymers (PCs) with poly(ethylene oxide) (PEO) side chain were synthesized using first an esterification reaction technique and second a free radical polymerization in aqueous solution. The resultant PCs have been characterized by Fourier transform infrared (FTIR) spectrum and gel permeation chromatography (GPC). The molecular structural parameters of PCs were determined from GPC and ion chromatography (IC). The dispersibility of PCs having different degree of polymerization (DP) of PEO side chain was investigated in cementitious system. Also, the mechanism of dispersion was

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Lin, Jer-Yi, Po-Yi Kuo, Ko-Li Lin, Chun-Chieh Chin, and Tien-Sheng Chao. "Junctionless Poly-Si Nanowire Transistors With Low-Temperature Trimming Process for Monolithic 3-D IC Application." IEEE Transactions on Electron Devices 63, no. 12 (2016): 4998–5003. http://dx.doi.org/10.1109/ted.2016.2615805.

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Li, Yang, Xu-Lin Xu, Dan Zhao, et al. "TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia." CNS Neuroscience & Therapeutics 21, no. 11 (2015): 905–13. http://dx.doi.org/10.1111/cns.12469.

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Huang, C., W. Jiang, and C. Chen. "Nano silica removal from IC wastewater by pre-coagulation and microfiltration." Water Science and Technology 50, no. 12 (2004): 133–38. http://dx.doi.org/10.2166/wst.2004.0705.

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Microfiltration (MF) coupled with pretreatment by coagulation was adopted in the treatment of chemical mechanical polishing (CMP) wastewater from IC manufacturing plants, containing high concentrations of silica. Poly-aluminium chloride (PACl) was the coagulant, while the cationic polyacrylamide (PAA) was the flocculant aid. Preliminary tests were performed with the raw CMP wastewater in order to determine the optimal coagulation condition for subsequent microfiltration. Analysis of the particle size distribution shows that nearly all silica particles were enlarged from nano scale to at least

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Wang, Chunhua, Jinbiao Lu, Weixin Du, et al. "Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection." Vaccine 37, no. 32 (2019): 4477–84. http://dx.doi.org/10.1016/j.vaccine.2019.06.078.

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Larouche, Annie, Patrick Berube, Philippe Sarret, and Sylvain Grignon. "Subacute H2O2, but not poly(IC), upregulates dopamine D2 receptors in retinoic acid differentiated SH-SY5Y neuroblastoma." Synapse 62, no. 1 (2007): 70–73. http://dx.doi.org/10.1002/syn.20458.

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Libermann, T. A., and D. Baltimore. "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor." Molecular and Cellular Biology 10, no. 5 (1990): 2327–34. http://dx.doi.org/10.1128/mcb.10.5.2327.

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The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and

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Libermann, T. A., and D. Baltimore. "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor." Molecular and Cellular Biology 10, no. 5 (1990): 2327–34. http://dx.doi.org/10.1128/mcb.10.5.2327-2334.1990.

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The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and

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Jafek, Jillian, Arvind Shakya, Pei-Yi Tai, Gerald J. Spangrude, Todd W. Kelley, and Dean Tantin. "Oct1 and Oca-B Regulate the Myeloid Leukemic Phenotype." Blood 128, no. 22 (2016): 2692. http://dx.doi.org/10.1182/blood.v128.22.2692.2692.

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Abstract Oct1, encoded by the Pou2f1 gene, is a widely expressed transcription factor that is associated with metabolic control, stress response, stem cell phenotypes and malignant transformation. Oct1 associates with a number of cofactors including the activating cofactor OCA-B encoded by Pou2af1. OCA-B is normally expressed specifically in B cells, but is misexpressed in about 30% of AML cases in myeloid cells and is a poor prognostic indicator. We observed a conserved Oct1 binding site in the promoter of Cdx2, a homeodomain transcription factor that is normally expressed solely in the gastr

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Rahimian, Sima, Marieke F. Fransen, Jan Willem Kleinovink, et al. "Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation." Journal of Controlled Release 203 (April 2015): 16–22. http://dx.doi.org/10.1016/j.jconrel.2015.02.006.

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Lappas, Martha. "KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium." REPRODUCTION 149, no. 5 (2015): 413–24. http://dx.doi.org/10.1530/rep-14-0597.

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The transcription factor Kruppel-like factor 5 (KLF5) has been shown to associate with nuclear factor kappa B (NFκB) to regulate genes involved in inflammation. However, there are no studies on the expression and regulation of KLF5 in the processes of human labour and delivery. Thus, the aims of this study were to determine the effect of i) human labour on KLF5 expression in both foetal membranes and myometrium; ii) the pro-inflammatory cytokine interleukin 1 beta (IL1β), bacterial product flagellin and the viral dsRNA analogue poly(I:C) on KLF5 expression and iii) KLF5 knockdown by siRNA in h

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Kim, Soo-Woo, Ho-Yong Choi, Sehyuk An, and Nam-Soo Kim. "Application of cascode level shifter for EMI reduction in LCD driver IC." Microelectronics International 32, no. 2 (2015): 73–80. http://dx.doi.org/10.1108/mi-11-2014-0052.

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Purpose – This paper aims to design the circuit for electromagnetic interface (EMI) reduction in liquid crystal display (LCD). Design/methodology/approach – The cascode level shifter and segmented driver circuit are applied in LCD column driver integrated circuit (IC) for EMI reduction. Cascode current mirror is used in the proposed level shifter for DC voltage biasing and reduction of the driving current which passes through the level shifter. The on-off switching currents and transient times are measured and compared between the conventional and proposed level shifters. Additionally, a segme

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Antonelli, Lis R. V., Antonio Gigliotti Rothfuchs, Ricardo Gonçalves, et al. "Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population." Journal of Clinical Investigation 120, no. 5 (2010): 1674–82. http://dx.doi.org/10.1172/jci40817.

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Nageswara Rao, K., G. Veerendra Nath, and K. Hari Kishore. "Crosstalk noise minimization in novel through silicon via structures." International Journal of Engineering & Technology 7, no. 2.8 (2018): 56. http://dx.doi.org/10.14419/ijet.v7i2.8.10325.

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In recent trends, through silicon via (TSV) is essential Technologies for 3-D IC integration because of its short interconnects length and high interconnect density. Beyond the existing structure of TSV, this paper provides a novel structure to investigate the crosstalk effect and same is simulated by using a SPICE simulator and 3-D field solver. The structure of the TSV comprises of copper surrounding by insulating liner, and silicon substrate. In existing structures, silicon dioxide (Sio2) is used as insulating liner because of its material compatibility with silicon substrate. Several resea

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