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Dissertations / Theses on the topic 'Poly-L-co-D'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Boix, Garriga Ester. "Biodegradable Poly(D,L-lactide) and Poly(D,L-lactide-co-glycolide) Nanoparticles for Photodynamic Therapy." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/368179.

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Aquesta tesi aprofundeix en l'estudi de les nanopartícules de poli-(D, L-làctid-co-glicòlid) (PLGA) o poli-(D, L-làctid) (PLA) i les seves nanopartícules homòlogues recobertes amb polietilenglicol (PEG) com a sistemes de vehiculització per fotosensibilitzadors emprats en teràpia fotodinàmica. En primer lloc s'ha investigat la influència de la matriu polimèrica i del recobriment superficial amb PEG sobre les característiques fisicoquímiques, fotofísiques i fotobiològiques de suspensions amb un fotosensibilitzador atrapat físicament. El recobriment amb PEG confereix una major estabilitat a les

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2

Eyovge, Gokcen. "Preparation And Characterization Of Poly(d,l-lactide-co-glycolide) Microspheres For Controlled Release Of Anticancer Drugs." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606382/index.pdf.

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Breast cancer is the most frequent type of cancer seen in woman. Chemotherapy is one of the most important treatments for breast cancer. However, systemic toxicity, drug resistance and unstable kinetics of the drug in the blood are serious problems of chemotherapy. The use of biodegradable polymers for controlled release of anticancer drugs has gained popularity in recent years. Controlled release of anticancer drugs from polymeric carriers has some advantages such as improvement in the efficiency of treatment, reduction in systemic toxicity and prevention of the drug resistance that is develo

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3

Albarki, Mohammed Abdulhussein Handooz. "Evaluation of poly D, L lactic-co-glycolic acid (PLGA) nanoparticle uptake pathways across the nasal mucosa." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6905.

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The nasal mucosa provides a non-invasive route for drug administration to the systemic circulation and potentially directly to the CNS. Nanoparticles made from biodegradable polymers, including PLGA, are of great interest for use in drug delivery systems due to their relative safety and ease of surface modification. Owing to their small size, nanoparticles may provide enhanced targeting and transport through the nasal mucosa. An improved understanding of the mechanisms and pathways of nanoparticle transfer across the nasal mucosa is needed to design effective new nasal delivery systems. This s

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4

Wittmar, Matthias. "Charge modified, comb-like graft polyesters for drug delivery and DNA vaccination synthesis and characterization of poly(vinyl dialkylaminoalkylcarbamate-co-vinyl acetate-co-vinyl alcohol)-graft-poly(D,L-lactide-co-glycolide)s /." [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0075/.

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5

Albarki, Mohammed Abdulhussein Handooz. "In vitro assessment of the transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) nanoparticles across the nasal mucosa." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/2034.

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The nasal mucosa provides a rapid, noninvasive route for drug administration to the systemic circulation and even potentially to the CNS. Nanoparticles made from the biodegradable polymer, PLGA, are of great interest for use in drug delivery systems due to PLGA’s relative safety and ease of surface modification. Nanoparticles may provide improved targeting and transport through the nasal mucosa. However, the optimal nanoparticle sizes and surface properties for intranasal delivery are unknown. In this study, we prepared PLGA nanoparticles within a size range of 50-70 nm containing the lipophil

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6

Duvvuri, Sridhar Mitra Ashim K. "Development and characterization of poly (D, L-lactide-co-glycolide) based sustained release formulation of ganciclovir in treatment of cytomegalovirus retinitis." Diss., UMK access, 2005.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2005.<br>"A dissertation in pharmaceutical science and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed Mar. 12, 2007; title from "catalog record" of the print edition. Includes bibliographical references (leaves 138-147). Online version of the print edition.

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7

Yang, Zhijie. "Development and characterisation of bioactive, bioresorbable α-tricalcium phosphate/ poly(D,L-lactide-co-glycolide) nanocomposite for bone substitution and fixation". Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611836.

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8

Pipes, Toni M. "CHARACTERIZING THE REPRODUCIBILITY OF THE PROPERTIES OF ELECTROSPUN POLY(D,L-LACTIDE-CO-GLYCOLIDE) SCAFFOLDS FOR TISSUE-ENGINEERED BLOOD VESSEL MIMICS." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1194.

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“Blood vessel mimics” (BVMs) are tissue-engineered constructs that serve as in vitro preclinical testing models for intravascular devices. The Cal Poly Tissue Engineering lab specifically uses BVMs to test the cellular response to stent implantation. PLGA scaffolds are electrospun in-house using the current “Standard Protocol” and used as the framework for these constructs. The performance of BVMs greatly depends on material and mechanical properties of the scaffolds. It is desirable to create BVMs with reproducible properties so that they can be consistent models that ultimately generate more

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9

Monteiro, Adriana Cristina Motta de Menezes. "Sintese e caracterização de dispositivos de poli (L-co- D, L acido latico) : estudo da degradação in vitro e in vivo." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263894.

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Orientador: Eliana Aparecida de Rezende Duek<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica<br>Made available in DSpace on 2018-08-14T11:38:37Z (GMT). No. of bitstreams: 1 Monteiro_AdrianaCristinaMottadeMenezes_D.pdf: 5297587 bytes, checksum: 9519d7cb25184a92ad96f65a3461d54a (MD5) Previous issue date: 2007<br>Resumo: Dispositivos bioreabsorvíveis têm sido intensivamente estudados para aplicações em ortopedia e traumatologia, no reparo de fraturas ósseas provenientes principalmente de traumas. O poli (L-co-D, L ácido láctico), PLDLA, na relação 70:30

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10

Weidenauer, Uwe. "Feasibility study for the microencapsulation of Pamidronate-disodium using D, L-Poly(lactide-co-glycolide acid-glucose): evaluation of different techniques and devices /." Marburg : Görich & Weiershäuser, 2000. http://www.gbv.de/dms/bs/toc/327657766.pdf.

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11

Gomes, Dos Santos Ana-Lucia. "Caractérisation et évaluation de microsphères de poly(D,L-acide lactique-co-glycolique)encapsulant un complexe (oligonucléotide antisens/polymère cationique) en vue d'une administration oculaire." Paris 11, 2005. http://www.theses.fr/2005PA114820.

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L'objectif de cette thèse a été la conception et l'évaluation d'un système d'administration intraoculaire d'oligonucléotides antisens. Cette forme pharmaceutique est constituée de microsphères de poly(D,L-acide lactique-co-glycolique) (PLGA) encapsulant des nanocomplexes oligonucléotides phosphorothioate anti-TGFβ-2/polyéthylèneimine. Les complexes préparés dans l'Hépès/NaCl ont montré une structure particulière de type «cœur couronne». In vitro, les complexes ont montré une capacité d'inhibition du TGFβ-2 aux niveau de l'ARNm et de l'expression de la protéine. In vivo, ces complexes ont été v

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12

Pena, Tiffany Richelle. "Preparation and Characterization of Electrospun Poly(D,L-lactide-co-glycolide) Scaffolds for Vascular Tissue Engineering and the Advancement of an In Vitro Blood Vessel Mimic." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/152.

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PREPARATION AND CHARACTERIZATION OF ELECTROSPUN POLY(D,L-LACTIDE-CO-GLYCOLIDE) SCAFFFOLDS FOR VASCULAR TISSUE ENGINEERING AND THE ADVANCEMENT OF AN IN VITRO BLOOD VESSEL MIMIC Tiffany Richelle Peña Currently, an estimated 1 in every 3 adult Americans are affected by one or more cardiovascular complications. The most common complication is coronary artery disease, specifically atherosclerosis. Outcomes of balloon angioplasty treatments have been significantly improved with the addition of drug eluting stents to the process. Although both bare metal and drug eluting stents have greatly increa

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Ocal, Yigit. "Development And Characterization Of Cortisone Derivative Drugcarrying Polymeric Microspheres." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612914/index.pdf.

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In this study, it is aimed to develop an injectable controlled release system of PCL and P(L,DL)LA microspheres loaded with TA and/or Ral for local treatment of rheumatoid arthritis which will avoid from systemic side effects of traditional administration and eliminate problems caused by direct local injections. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder that most commonly causes inflammation and tissue damage in joints and tendon sheaths. Current strategies for the disease are mainly towards relieving symptoms and increasing mobility. The microsphere form drug deliv

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Patel, Deven Chandrakant. "PREPARATION AND CHARACTERIZATION OF ELECTROSPUN POLY (D,L-LACTIDE-CO-GLYCOLIDE) SCAFFOLDS FOR VASCULAR TISSUE ENGINEERING AND THE ADVANCEMENT OF AN IN VITRO BLOOD BRAIN BARRIER MODEL." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/824.

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Developing an in vitro Blood Brain Barrier model that will replicate the physiological, anatomical, and functional characteristics of the native BBB has gained significant attention. Such a model would enable prediction of the penetration of CNS targeting drug candidates across the BBB, allow pre-screening and optimization strategies to be developed for new drugs and gene delivery formulations, and permit research groups to further understand how a dysfunctional BBB is involved in the pathogenesis of several neurological diseases. The Tissue Engineering laboratory at the California Polytechni

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15

Lazaro, Lourdes Marcela Yataco. "Quantificação de fármacos antituberculose em nanofibras por eletroforese capilar." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-06122017-103332/.

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Apesar de ser uma das doenças infecciosas mais antigas e bem conhecidas, a tuberculose (TB) permanece como a segunda maior causa de morte após a síndrome da imunodeficiência adquirida. A TB é uma doença infecciosa e transmissível, causada pela bactéria Mycobacterium tuberculosis (Mtb), que afeta prioritariamente os pulmões, embora possa acometer outros órgãos e sistemas. O presente trabalho teve como objetivo desenvolver nanofibras e nanoesferas de poli (D,L-láctico co-glicólico) (PLGA) contendo os Insumos Farmacêuticos Ativos (IFAs), rifampicina e isoniazida; caracterizá-las físico quimicamen

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Demetci, Demet. "Preparation And Evaluation Of Polymer Based Microcarriers For Hydrophobic Anti-cancer Drugs." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/2/12609041/index.pdf.

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Chemotherapy is one of the most important treatments for cancer. However, systemic toxicity, drug resistance and unstable kinetics of the drug in the blood are serious problems of chemotherapy. The use of biodegradable polymers for controlled release of anticancer drugs has gained popularity in recent years. Controlled release of drugs from polymeric carriers has some advantages such as improvement in the efficiency of treatment, reduction in systemic toxicity and prevention of the drug resistance that is developed by the cancer cells. In this study, poly(D,L-lactide-co-glycolide) microparti

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17

Castillo, Yvette S. "DESIGN OF EXPERIMENTATION TO SYSTEMATICALLY DETERMINE THE INTERACTION BETWEEN ELECTROSPINNING VARIABLES AND TO OPTIMIZE THE FIBER DIAMETER OF ELECTROSPUN POLY (D,L-LACTIDE-CO-GLYCOLIDE) SCAFFOLDS FOR TISSUE ENGINEERED CONSTRUCTS." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/780.

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Cardiac disease causes approximately a third of the deaths in the United States. Furthermore, most of these deaths are due to a condition termed atherosclerosis, which is a buildup of plaque in the coronary arteries, leading to occlusion of normal blood flow to the cardiac muscle. Among the methods to treat the condition, stents are devices that are used to restore normal blood flow in the atherosclerotic arteries. Before advancement can be made to these devices and changes can be tested in live models, a reliable testing method that mimics the environment of the native blood vessel is needed.

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18

Baydemir, Tuncay. "Investigations On The Properties And Drug Releases Of Biodegradable Polymer Coatings On Metal Substrates As Drug Carriers." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611140/index.pdf.

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The use of various biodegradable polymers for the improvement of different controlled and long-lasting drug release systems is an active research area in recent years. The application of different metal prostheses, especially titanium based ones, to the human body is also very common. A most important disadvantage of these prostheses is the risk of infection at the application areas that necessitates the removing of the prosthesis with a second surgical operation and reapplication of it after recovery. One of the best ways to solve this problem is to render metal prostheses infection free with

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19

Kim, NaJung. "Rationale design of polymeric siRNA delivery systems." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1237.

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Regulation of gene expression using small interfering RNA (siRNA) is a promising strategy for research and treatment of numerous diseases. However, siRNA cannot easily cross the cell membrane due to its inherent instability, large molecular weight and anionic nature. For this reason, a carrier that protects, delivers and unloads siRNA is required for successful gene silencing. The goal of this research was to develop a potential siRNA delivery system for in vitro and in vivo applications using cationic polymers, chitosan and polyethylenimine (PEI), poly(ethylene glycol) (PEG), mannose, and pol

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Barauna, Grazielle dos Santos. "Obtençao e caracterização de membranas de PLDLA em aplicação como protese para regeneração nervosa periferica." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263844.

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Orientador: Eliana Aparecida de Resende Duek<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica<br>Made available in DSpace on 2018-08-09T22:07:51Z (GMT). No. of bitstreams: 1 Barauna_GrazielledosSantos_M.pdf: 1217156 bytes, checksum: ded7e97c7818fe0c3d87cb97d8c8f8aa (MD5) Previous issue date: 2007<br>Mestrado<br>Materiais e Processos de Fabricação<br>Mestre em Engenharia Mecânica

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Silva, Katia Fernanda. "Cultura de osteoblastos sobre arcabouço da blenda de PCL/PLGA : estudo in vitro e in vivo." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263835.

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Orientador: Eliana Aparecida de Rezende Duek<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica<br>Made available in DSpace on 2018-08-14T20:10:35Z (GMT). No. of bitstreams: 1 Silva_KatiaFernanda_M.pdf: 16700696 bytes, checksum: 568261b128b361204100ac55aba7640b (MD5) Previous issue date: 2008<br>Resumo: A Ciência dos Biomateriais é uma área de conhecimento multidisciplinar e está relacionada a implantes cirúrgicos e dispositivos médicos e odontológicos. Dentre as atuais aplicações dos biomateriais, a utilização de polímeros biorreabsorvíveis como

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22

Zhang, Yu. "Inverse opal scaffolds and photoacoustic microscopy for regenerative medicine." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50231.

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This research centers on the fabrication, characterization, and engineering of inverse opal scaffolds, a novel class of three-dimensional (3D) porous scaffolds made of biocompatible and biodegradable polymers, for applications in tissue engineering and regenerative medicine. The unique features of an inverse opal scaffold include a highly ordered array of pores, uniform and finely tunable pore sizes, high interconnectivity, and great reproducibility. The first part of this work focuses on the fabrication and functionalization of inverse opal scaffolds based on poly(D,L-lactic-co-glycolic acid)

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Tran, Dai Lam. "Capteur d'ADN à base d' un nouveau polymère conducteur fonctionnalisé : détection électrochimique directe de l' hybridation." Paris 7, 2003. http://www.theses.fr/2003PA077120.

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24

Plum, Georg [Verfasser]. "Freisetzungsverhalten von unterschiedlich hydrophil,hydrophoben Modellsubstanzen aus Poly-(D,L-lactid) und Poly-(D,L-Lactid)-co-PEO-co-poly-(D,L-lactid)-Mikrosphären und pharmazeutische Anwendungen / vorgelegt von Georg Plum." 2004. http://d-nb.info/97257509X/34.

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25

Schmitz, Reinhard. "Entwicklung von Herstellungsverfahren für wirkstofffreie und wirkstoffhaltige Poly (D,L-lactid-co-glycolid)-Mikropartikeln /." 1996. http://www.gbv.de/dms/bs/toc/22632141X.pdf.

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Guo, Shu-Hung, and 郭書宏. "The Morphology of Poly(D,L-lactide-co-glycolide) Films Observed by Atomic Force Microscope." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/32554499794438959916.

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碩士<br>國立宜蘭大學<br>生物機電工程學系碩士班<br>99<br>In vitro release of hydrophilic colchicine from biodegradable poly(D,L-lactide-co-glycolide) (PLGA) copolymer films was studied by applying the high-performance liquid chromatography. The results showed that the release rates of hydrophilic colchicine from various PLGA films within 28 days exhibited a fast initial release and two-stage release involving zero-order kinetics and degradation release. Atomic force microscopy (AFM) is a high-resolution imaging tool that successfully visualizes the morphology of biological molecular assemblies at nanometer-scale

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Guan, Dechi. "Preparation and characterization of paclitaxel-loaded poly(d,l-lactide-co-glycolide) microspheres for intra-articular injection." Thesis, 1999. http://hdl.handle.net/2429/9672.

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Paclitaxel has been shown to cause significant regression of existing rheumatoid arthritis and to prevent the induction of collagen-induced arthritis (CIA) in animal models. Paclitaxel suppresses arthritis because rapidly proliferating inflammatory pannus cells in the joint are susceptible to the phase-specific cytotoxic effects of paclitaxel. Intra-articular therapy using anti-inflammatory steroids is used for patients in whom rheumatoid arthritis manifests itself in only a limited number of joints. The objective of the research was to prepare and characterize paclitaxel-loaded microsph

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Wittmar, Matthias [Verfasser]. "Charge modified, comb-like graft polyesters for drug delivery and DNA vaccination : synthesis and characterization of poly(vinyl dialkylaminoalkylcarbamate-co-vinyl acetate-co-vinyl alcohol)-graft-poly(D,L-lactide-co-glycolide)s / vorgelegt von Matthias Wittmar." 2004. http://d-nb.info/972867651/34.

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Sefat, Farshid, Í. Ortega, R. McKean, et al. "An “off-the shelf” Synthetic Membrane to Simplify Regeneration of Damaged Corneas." 2014. http://hdl.handle.net/10454/11155.

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yes<br>Our overall aim is to develop a synthetic off-the-shelf alternative to human amniotic membrane which is currently used for delivering cultured limbal stem cells to the cornea in patients who suffer scarring of the cornea because of the loss of limbal stem cells. We have recently reported that both cultured cells and limbal explants grow well on electrospun Poly(D,L-lactide-co-glycolide) (PLGA) (44 kg/mol) with a 50:50 ratio of lactide and glycolide and sterilized with γ-irradiation. Prior to undertaking a clinical study our immediate aim now is to achieve long term storage of the membra

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Lu, Zi-Ting, and 呂姿霆. "Use of Poly (D, L-lactic-co-glycolide) particles as an antigen-carrier to enhance immune response to LTB." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ngauju.

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碩士<br>國立屏東科技大學<br>動物疫苗科技研究所<br>105<br>Enterotoxigenic Escherichia coli (ETEC) is a major pathogen that causes serious diarrhea in young animals, thereby affecting the feed conversion rate (FCR). Serious ETEC infection may lead to death and result in significant economic losses in livestock. ETEC can produce two enterotoxins, heat-labile enterotoxin (LT) and heat-stable enterotoxin (ST). LT, an AB toxin, is an important virulence factor of ETEC. The B subunit (LTB) binds to GM1 ganglioside receptor of intestinal epidermal cells and carries the toxic subunit A (LTA) into cell, resulting in water

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Shie, Ji-Chen, and 謝季辰. "Phase Transition、Micelle Properties and Drug Release Behavior in Thermosensitive Oligomeric Monomethoxy Poly(ethylene glycol) -Poly(D,L-lactic-co-glycolic acid) (mPEG-PLGA) Diblock Copolymer Gels." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/43480225515802636322.

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碩士<br>國立臺灣科技大學<br>材料科學與工程系<br>101<br>Monomethoxy poly(ethylene glycol)-Poly(D,L-lactic-co-glycolic acid) (mPEG-PLGA) diblock copolymers with fixed mPEG length (degree of polymerization =12.50) and various PLGA lengths (degree of polymerization = 17.59 to 23.75) were synthesized. The molar ratio of DLLA and GA is 58:42 to 55:45 . Phase diagrams were determined by the tube inverting method and rheometry. The critical micelle concentrations (CMC) and micellar radius were determined by UV/Vis spectroscopy with dye solubilization and dynamic light scattering, respectively . Based on Leibler theory

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Weiland-Waibel, Andrea. "Herstellung und Charakterisierung von biodegradierbaren Mikropartikeln aus Poly(D,L-lactid-co-glycolid) und Cyclodextrin-Komplexen mit Bupivacainhydrochlorid für parenterale Depotarzeneiformen /." 1994. http://www.gbv.de/dms/bs/toc/183442113.pdf.

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Chang, Hung-Ju, and 張宏如. "Effect of Length of Polyester Segments on Phase Transition and Micelle Properties in Oligomeric Monomethoxy Poly(ethylene glycol) -Poly(D,L-lactic-co-glycolic acid) (mPEG-PLGA) Diblock Copolymers." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/mvsthj.

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碩士<br>國立臺灣科技大學<br>材料科學與工程系<br>99<br>Monomethoxy poly(ethylene glycol)-Poly(D,L-lactic-co-glycolic acid) (mPEG-PLGA) diblock copolymers with fixed mPEG length ( =550 g/mol) and various PLGA lengths (monomer number from 10 to 12) were synthesized. Phase diagrams were determined by the tube inverting method and rheometry. The critical micelle concentrations (CMC) and micellar radius were determined by UV/Vis spectroscopy with dye solubilization and dynamic light scattering, respectively. Rheometric measurement showed three phases (sol, gel and precipitate), whereas the tube inverting method two

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Tseng, Yuan Yun, and 曾元昀. "The Application of Biodegradable Poly [(d,l)-lactide-co-glycolide] Nanofibrous Membranes in the Treatment of Post-operative/ Post-traumatic Central Nervous System Infection." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/49885268189114166676.

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博士<br>長庚大學<br>機械工程學系<br>102<br>The incidence of postoperative central nervous system infection (PCNSI) is higher than 5-7%. Successful treatment of a central nervous infection requires aspiration of the pus or excision of the abscess, followed by long-term (usually 4-8 weeks) parenteral antibiotic treatment. Local antibiotic delivery using biodegradable drug-impregnated carriers is effective in treating postoperative infections, thereby reducing the toxicity associated with parenteral antibiotic treatment and the expense involved with long-term hospitalization. Firstly, We developed vancomycin

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