Log in

Relevant bibliographies by topics / Polychromatophilic red blood cells / Journal articles

To see the other types of publications on this topic, follow the link: Polychromatophilic red blood cells.

Journal articles on the topic 'Polychromatophilic red blood cells'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Polychromatophilic red blood cells.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Bhattacherjee, Ananya. "Avian Erythrocytes and Agranulocytes - a Review." Science Reviews. Biology 2, no. 2 (2023): 21–29. http://dx.doi.org/10.57098/scirevs.biology.2.2.2.

Full text

Abstract:

This study reports on the morphology of red blood cells and agranulocytes in various types of birds, such as rheas, emus, ostriches, chickens, and geese. Though all of them have the typical avian similarity in blood cells, yet there are some differences. Along with normal and mature erythrocytes, lymphocytes, and monocytes, the present study also focuses on rubricytes, reticulocytes, poikilocytes, polychromatophilic erythrocytes, reactive lymphocytes, pleomorphic monocyte nuclei, etc.

APA, Harvard, Vancouver, ISO, and other styles

2

Kolesnik, Evgeniy, M. Derho, and Maksim Rebezov. "Functional morpho-densitometric parameters of chromatin of the nucleus and cytoplasm of erythroblasts and red blood cells of birds in postembryonic ontogenesis." Agrarian Bulletin of the 24, no. 01 (2024): 59–85. http://dx.doi.org/10.32417/1997-4868-2024-24-01-59-85.

Full text

Abstract:

Abstract. The purpose is to characterize the development of the synthetic activity of polychromatophilic erythroblasts and erythrocytes, in particular the status of the hemoglobin-synthesized function of avian erythroid cells in early postembryonic ontogenesis. Methods. The experimental part of the study was carried out in the conditions poultry farm of “Chebarkul’skaya ptitsa” (Chebarkul district of the Chelyabinsk region, Russia). The whole blood of Hubbard ISA F15 broiler chickens of four age groups (n = 40) was studied: group I – 1-day-old chicks; II – 7-day-old chickens; III – 23-day-old

APA, Harvard, Vancouver, ISO, and other styles

3

Kolesnik, Evgeniy A., Marina A. Derkho, and Maksim B. Rebezov. "Functional morpho-densitometric parameters of chromatin of the nucleus and cytoplasm of erythroblasts and red blood cells of birds in postembryonic ontogenesis." Agrarian Bulletin of the Urals 24, no. 01 (2024): 59–85. https://doi.org/10.32417/1997-4868-2024-24-01-59-85.

Full text

Abstract:

<em><strong>Abstract.</strong></em> The purpose is to characterize the development of the synthetic activity of polychromatophilic erythroblastsand erythrocytes, in particular the status of the hemoglobin-synthesized function of avian erythroid cellsin early postembryonic ontogenesis. <em><strong>Methods.</strong></em> The experimental part of the study was carried out in the conditionspoultry farm of “Chebarkul’skaya ptitsa” (Chebarkul district of the Chelyabinsk region, Russia). The wholeblood of Hubbard ISA F15 broiler chickens of four age groups (n=40) was studied: group

APA, Harvard, Vancouver, ISO, and other styles

4

Soldatov, A. A., V. N. Rychkova, T. A. Kukhareva, and A. G. Rokotova. "Cellular Composition of Erythroid Forms in the Blood and Head Kidney of the Golden Grey Mullet (<i>Chelon auratus</i> Risso, 1810) during the Annual Cycle." Российский физиологический журнал им И М Сеченова 109, no. 7 (2023): 990–1001. http://dx.doi.org/10.31857/s0869813923070130.

Full text

Abstract:

The changes in the number of erythrocytes in the blood and the production of erythrocytes by the hematopoietic tissue of the golden grey mullet (Chelon auratus Risso, 1810) during the annual cycle were studied. Catching and delivery of fish to the aquarium was carried out monthly. The content of immature erythroid forms was determined: erythroblasts, basophilic and polychromatophilic normoblasts, in the head kidney (pronephros) and circulating blood. It has been established that the processes of erythropoiesis in the hematopoietic tissue of the golden grey mullet proceed irregularly. The activ

APA, Harvard, Vancouver, ISO, and other styles

5

Hedayanti, Noor, and Arif Wahyudi. "Review of Physiological Aspects of Erythropoiesis: A Narrative Literature Review." Sriwijaya Journal of Internal Medicine 1, no. 1 (2023): 19–25. http://dx.doi.org/10.59345/sjim.v1i1.20.

Full text

Abstract:

Erythropoiesis is the development of red blood cells. Within the confines of the bone marrow, erythroid progenitor cells proliferate and differentiate into large nucleated proerythroblasts, which are committed to producing cells of the erythroid series. This literature review aimed to describe the physiology of erythropoiesis and its application in medical science. All stages of erythroid development are referred to as the erythron. Proerythroblasts, which possess ribosomes and can produce proteins, differentiate through several forms between erythroblasts while synthesizing hemoglobin and pro

APA, Harvard, Vancouver, ISO, and other styles

6

Soldatov, A. A. "MONOCYCLICITY IN THE FUNCTIONING OF THE ERYTHROID GERM OF HEMATOPOIESIS IN TELEOSTEAN FISH, FOR EXAMPLE OF <i>Platichthys flesus</i> (LINNAEUS, 1758)." Доклады Российской академии наук. Науки о жизни 512, no. 1 (2023): 495–99. http://dx.doi.org/10.31857/s2686738923600395.

Full text

Abstract:

The erythron state was studied in the flounder-gloss (Platichthys flesus, Linnaeus, 1758) during the annual cycle. The number of erythrocytes in the blood and the content of immature erythroid forms were determined: basophilic and polychromatophilic normoblasts in the head kidney (pronephros) and bloodstream. The proliferative activity of cells was judged by the inclusion of 3H-thymidine in immature erythrocytes of circulating blood. It has been showed that the processes of erythropoiesis in the hematopoietic tissue of the flounder-gloss proceed irregularly. The active production of erythroid

APA, Harvard, Vancouver, ISO, and other styles

7

Karmanova, E. E., A. V. Chernikov, A. M. Usacheva та V. I. Bruskov. "Radio-mitigation properties of α-lipoic acid when used alone and in combination with metformin or ethylmethylhydroxypyridine succinate (mexidol) in mice after exposure to X-ray radiation". Биофизика 68, № 4 (2023): 761–69. http://dx.doi.org/10.31857/s0006302923040178.

Full text

Abstract:

This study explored the radio-mitigation properties of α-lipoic acid and combination of α-lipoic acid with metformin and mexidol in animals during the process of X-ray irradiation. The results of the micronucleus test for measuring radiation-induced DNA damage of polychromatophilic red blood cells in the bone marrow of mice showed that α-lipoic acid has gene-protective and radio-mitigation properties in vivo. A study on the survival rate of the lethal dose-irradiated mice within 30 days confirmed that α-lipoic acid has radio-mitigation properties. The radio-mitigation effect of α-lipoic acid i

APA, Harvard, Vancouver, ISO, and other styles

8

Soldatov, A. A., I. A. Parfyonova, T. A. Kukhareva, N. E. Shalagina, and V. N. Rychkova. "Characteristics of erythron of the head kidney and circulating blood of the flounder gloss (<i>Platichthys flesus</i>) during the annual cycle." Biologiâ vnutrennih vod 17, no. 5 (2024): 820–27. https://doi.org/10.31857/s0320965224050138.

Full text

Abstract:

The erythron composition of the head kidney (pronephros) and circulating blood in the cold-loving flounder-gloss (Platichthys flesus L., 1758) during the annual cycle was studied. The erythron of pronephros was mainly represented by erythroblasts (EB) and basophilic normoblasts (BN). The content of polychromatophilic normoblasts (PN) was low (less than 2%). The maximum size of the erythroid germ of hematopoiesis in the pronephros was noted during the post-spawning period (April–July). It accounted for up to 17% of the cellular mass of the prints. BN and PN, which were not capable of proliferat

APA, Harvard, Vancouver, ISO, and other styles

9

Чшиев, Т. В. "The modifying impact of melaxen on the genotoxic effects of chronic cadmium intoxication in rats." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 9(218) (September 30, 2020): 105–6. http://dx.doi.org/10.25557/2073-7998.2020.09.105-106.

Full text

Abstract:

С использованием микроядерного теста было показано протекторное влияние мелаксена (10 мг/кг) при хронической экспериментальной интоксикации кадмием (0,3 мг/кг) в крови крыс, p<0,001. Исследуемый лекарственный препарат продемонстрировал способность снижать ожидаемое число микроядер и полихроматофильных эритроцитов (ПХЭ), индуцированных кадмием при двухнедельной и месячной экспозиции. При хроническом внутрижелудочном введении мелаксена не зафиксирован рост числа микроядер и ПХЭ по сравнению с контролем, p>0,05. Using the micronucleus test, the protective effect of melaxen (10 mg / kg) was

APA, Harvard, Vancouver, ISO, and other styles

10

Kolesnik, Evgeniy A., Marina A. Derkho, and Maksim B. Rebezov. "Forms of degeneration of blood cells, their physiological and clinical significance, mechanisms of formation, shadows of cells in blood smears of birds." Agrarian science 378, no. 1 (2024): 65–74. https://doi.org/10.32634/0869-8155-2024-378-1-65-74.

Full text

Abstract:

<strong>ABSTRACT</strong><strong><em>Relevance.</em> </strong>An overview is presented of the patterns of appearance, physiological and clinical significance of shadowsof cells, a comparative experimental cytomorphological analysis using the example of polychromatophilic erythroblasts(<em>PolyErythro</em>), shadows of erythroblast (<em>ShadErythro</em>) and undifferentiated shadows cells of in peripheral blood smears ofchickens <em>Gallus gallus</em> L.<em><strong>Methods.</strong></em> The studied individuals were divided into four groups (n=40) depending on the age of the chickens(<em>Postem

APA, Harvard, Vancouver, ISO, and other styles

11

Fedonenko, Olena, Nataliіa Yesipova, and Tetyana Sharamok. "The Accumulation of Heavy Metals and Cytometric Characteristics Features of Red Blood Cells in Different Ages of Carp Fish from Zaporozhian Reservoir." International Letters of Natural Sciences 53 (April 2016): 72–79. http://dx.doi.org/10.18052/www.scipress.com/ilns.53.72.

Full text

Abstract:

The research was held in terms of Zaporozhian Reservoir (Ukraine) from 2014 till 2015 year. It was established that prussian carp (Carassius gibelio Bloch, 1782) and roach (Rutilus rutilus Linnaeus, 1758) underyearlings accumulate essential elements more extensively, especially zinc, comparing to adults ones. The species characteristic of heavy metals accumulation in the carp fish body was observed. The intensity level of erythropoiesis occurrence was higher in young fish of both species of carp fish. The specific features of cytometric characteristics of fish erythrocytes were identified: the

APA, Harvard, Vancouver, ISO, and other styles

12

Fedonenko, Olena, Nataliіa Yesipova, and Tetyana Sharamok. "The Accumulation of Heavy Metals and Cytometric Characteristics Features of Red Blood Cells in Different Ages of Carp Fish from Zaporozhian Reservoir." International Letters of Natural Sciences 53 (April 1, 2016): 72–79. http://dx.doi.org/10.56431/p-29j097.

Full text

Abstract:

The research was held in terms of Zaporozhian Reservoir (Ukraine) from 2014 till 2015 year. It was established that prussian carp (Carassius gibelio Bloch, 1782) and roach (Rutilus rutilus Linnaeus, 1758) underyearlings accumulate essential elements more extensively, especially zinc, comparing to adults ones. The species characteristic of heavy metals accumulation in the carp fish body was observed. The intensity level of erythropoiesis occurrence was higher in young fish of both species of carp fish. The specific features of cytometric characteristics of fish erythrocytes were identified: the

APA, Harvard, Vancouver, ISO, and other styles

13

B., Afolabi Olakunle, O. I. Oloyede, and Oladimeji Tugbobo. "Effect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration." Journal of Phytopharmacology 3, no. 4 (2014): 238–41. http://dx.doi.org/10.31254/phyto.2014.3403.

Full text

Abstract:

Phytomedicine is a subject that is now gaining relevance worldwide aiding treatment for diseases that were once incurable among folks in which genotoxicity is a prominent one. The present study was designed to examine the ability of Talinum triangulare (water leaf) to protect the genomic integrity of swiss albino rat from lead-induced chromosomal damage in the bone marrow red blood cells. 20 eight week old rats were divided into five groups with group 1 as the negative control and group 2 is the positive control and the other groups, all treated by gavage once per day with a single dose of 2.5

APA, Harvard, Vancouver, ISO, and other styles

14

Kolesnik, Evgeny Anatolyevich, and Marina Arkadyevna Derkho. "Characterizing the morphophysiology problems of blood cells of chickens' neonatal ontogenesis. Report I. The features of postembryonic hematopoiesis, differences in approaches and problems of morphofunctional blood analysis (review)." Agro-Industrial Complex of Russia 26, no. 4 (2019): 637–43. https://doi.org/10.5281/zenodo.4385556.

Full text

Abstract:

A review of the complex of differences between the algorithms of scientific schools in morphology and morphofunctional analysis of chickens’ peripheral blood of postnatal ontogenesis is presented. The hematopoiesis features of broiler chickens <em>Gallus gallus</em> (L.) at their early ontogenesis period after birth are characterized. The classification and causes of differences in the nomenclature of the formed elements of chickens’ blood are discussed in comparison with mammals. <em><strong>Keywords:</strong></em> blood morphology, erythroblasts, erythropoiesis, hemocytopoiesis,

APA, Harvard, Vancouver, ISO, and other styles

15

Kolesnik, Evgeny Anatolyevich, and Marina Arkadyevna Derkho. "Characterizing the morphophysiology problems of blood cells of chickens' neonatal ontogenesis. Report II. Characterizing the differential morphophysiological markers of chickens' blood cells." Agro-Industrial Complex of Russia 26, no. 4 (2019): 644–52. https://doi.org/10.5281/zenodo.4385940.

Full text

Abstract:

The morphofunctional characteristic of the peripheral blood cell ensemble of broiler chickens <em>Gallus gallus</em> (L.) of early postnatal ontogenesis is presented. It is based on the analysis of high-resolution color micrographs made with light-optical microscopy. The work is a practical result to continue the comprehensive study of the morphophysiology of the blood cells of broiler chickens in the early period of ontogenesis after birth. <em><strong>Keywords</strong></em>: blood morphology, erythroblasts, erythropoiesis, mitosis, hemocytopoiesis, heterophiles, eosinophils, basophils, lymph

APA, Harvard, Vancouver, ISO, and other styles

16

Rodrigues, François, Giulia Hardouin, Sara El Hoss, et al. "Vexas Syndrome Is a New Cause of p53-Mediated Erythroblastopenia." Blood 144, Supplement 1 (2024): 36. https://doi.org/10.1182/blood-2024-208122.

Full text

Abstract:

Introduction: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a recently identified autoinflammatory disorder caused by somatic mutations in the UBA1 gene, resulting in a deep but cytoplasmic-restricted ubiquitylation defect1. VEXAS is characterized by a macrocytic anaemia despite inflammation, which is not fully understood. We hypothesized that UBA1-mutated erythroblasts could generate pathological red cells responsible for the anaemia and contributing to systemic inflammation through impaired erythrophagocytosis. Thus, we characterized red cells and erythroblasts in VEXAS

APA, Harvard, Vancouver, ISO, and other styles

17

De Franceschi, Lucia, Luisa Ronzoni, Achille Iolascon та ін. "Pharmacological Inhibition of K-Cl Cotransport Alters In Vitro Maturation of Normal and β-Thalassemic Human Erythroid Progenitors." Blood 106, № 11 (2005): 3819. http://dx.doi.org/10.1182/blood.v106.11.3819.3819.

Full text

Abstract:

Abstract The K-Cl cotransporter family (KCC) plays a crucial role in cell volume regulation, and KCC1 and KCC3 have been reported to participate in cell growth events (Shen MR, PNAS98, 2001; Shen MR JBC278, 2003). Expression of KCC1, KCC3 and KCC4 has been reported in erythroid cells. In β-thalassemic red blood cells (RBCs), K-Cl cotransport activity is abnormally activated and contributes to red cell loss of water and K. This study evaluated the gene expression of two KCC gene products and the effects of the KCC inhibitor [(dihydroindoenyl)oxy]alkanoic acid (DIOA) on in vitro liquid-culture e

APA, Harvard, Vancouver, ISO, and other styles

18

Yurchenko, Valentina V., Lyudmila V. Akhaltseva, Mariya A. Konyashkina, and Nadezda A. Yurtseva. "Evaluation of the cytogenetic activity of the food dye Azorubine in a micronucleus test in mice." Hygiene and sanitation 102, no. 6 (2023): 580–83. http://dx.doi.org/10.47470/0016-9900-2023-102-6-580-583.

Full text

Abstract:

Introduction. Azorubine E122 (Carmoisine, Food Red 3) monoazo dye is used in the manufacture of desserts, caramels, sweets, marmalades, ice cream, alcoholic and non-alcoholic drinks, etc. The safety assessment of food additives includes the study of genotoxic potential. At the same time, for substances with a high or a small but long-term exposure (including food additives), in vivo tests are required. Materials and methods. The genotoxic activity of aqueous solutions of synthetic food azo dyes E122 Azorubin was studied by the micronuclear method on bone marrow cells in mice (males, hybr

APA, Harvard, Vancouver, ISO, and other styles

19

Pimentel, Harold, Marilyn Parra, Jie Li, et al. "A Dynamic Alternative Splicing Program Regulates Gene Expression In A Differentiation Stage-Specific Manner During Terminal Erythropoiesis." Blood 122, no. 21 (2013): 3413. http://dx.doi.org/10.1182/blood.v122.21.3413.3413.

Full text

Abstract:

Abstract Spatio-temporal regulation of switches in alternative pre-mRNA splicing modulate exon usage, critically remodeling the transcriptome during development and differentiation of many tissues, while aberrant regulation of alternative splicing disrupts these processes and plays a role in numerous human diseases. Recently, the discovery of splicing factor mutations in myelodysplasia has increased interest in splicing regulation in hematology. Previously, a functionally critical erythroid splicing switch in protein 4.1 pre-mRNA has been reported, in which activation of alternative exon 16 sp

APA, Harvard, Vancouver, ISO, and other styles

20

Webb, Dylan C., Cesar Colorado-Jimenez, Maly Fenelus, et al. "Deep Learning-Driven 24-Hour Mortality Risk Assessment through Peripheral Blood Smear Morphology in Hospitalized Cancer Patients." Blood 144, Supplement 1 (2024): 4992. https://doi.org/10.1182/blood-2024-208716.

Full text

Abstract:

Introduction: Mortality in cancer pateints is often preceded by catastrophic hematologic and inflammatory syndromes such as the systemic inflammatory response syndrome/sepsis, disseminated intravascular coagulation (DIC), microangiopathic hemolytic anemia, hemophagocytic lymphohistiocytosis, and cytokine release syndrome. These conditions alter peripheral blood cells, causing changes in the morphology of red blood cells (RBC), white blood cells (WBC) and platelets in peripheral blood smears (PBS). We hypothesize that attention-based deep learning models using PBS feature embeddings can predict

APA, Harvard, Vancouver, ISO, and other styles

21

Shaukat, Farah, Zeba Singh, and Hira Latif. "Dehydrated Hereditary Stomatocytosis: A Rare Inherited Hemolytic Anemia." Blood 138, Supplement 1 (2021): 4148. http://dx.doi.org/10.1182/blood-2021-150968.

Full text

Abstract:

Abstract Background: Dehydrated hereditary stomatocytosis (DHSt), also known as hereditary xerocytosis, is a rare congenital hemolytic anemia with an autosomal dominant inheritance. It is often misdiagnosed for other hemolytic conditions, such as hereditary spherocytosis. Herein, we present the case of a young female presenting with hemolytic anemia, who was found to have a mutation in PIEZO1 gene and was subsequently diagnosed with DHSt. Case Presentation: A 39-year-old woman of Asian origin presented to the hematology clinic for evaluation of anemia diagnosed on blood work performed by prima

APA, Harvard, Vancouver, ISO, and other styles

22

Brindley, Elena C., Emily Hartman, Julien Papoin, et al. "RASA3 Deficiency Contributes to Anemia By Multiple Mechanisms." Blood 130, Suppl_1 (2017): 920. http://dx.doi.org/10.1182/blood.v130.suppl_1.920.920.

Full text

Abstract:

Abstract RASA3, a Ras GTPase activating protein, is critical to vertebrate erythropoiesis and megakaryopoiesis. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a G125V mutation in Rasa3 that leads to profound bone marrow failure with characteristics of aplastic anemia. The phenotype is cyclic, and mice alternate between periods of crisis and remission. Our previous studies demonstrated that this mutation in Rasa3 causes defects in several aspects of erythropoiesis, including a significant delay of erythroid differentiation at the polychromatophili

APA, Harvard, Vancouver, ISO, and other styles

23

Wang, Daren, Wei Zhang, Theodosia A. Kalfa, Punam Malik, and Dao Pan. "High Level Production of a Lysosomal Enzyme from HSC-Derived Erythroid Cells for Therapeutic Correction of Hurler Syndrome in Mice." Blood 112, no. 11 (2008): 2355. http://dx.doi.org/10.1182/blood.v112.11.2355.2355.

Full text

Abstract:

Abstract Proviral integration into hematopoietic stem cells (HSC) by lentivirus vector (LV)- mediated gene transfer can provide the benefit of life-long therapeutic effect, yet it can also bring the risk of insertional oncogenesis. Restricting transgene expression to late erythroblasts and red blood cells (RBC) may reduce the risk of activating oncogenes in HSC and its offspring in all lineages. In this study, we sought to evaluate the feasibility of redirecting a fraction of robust protein-synthesis machinery in maturing erythroid cells for production of alpha-L-iduronidase (IDUA), the lysoso

APA, Harvard, Vancouver, ISO, and other styles

24

Dulmovits, Brian M., Yue Zhao, Luanne L. Peters, and Lionel Blanc. "RASA3 Is Involved in Cell Cycle Progression, Hemoglobinization and Generation of Reactive Oxygen Species during Mammalian Erythropoiesis." Blood 126, no. 23 (2015): 3328. http://dx.doi.org/10.1182/blood.v126.23.3328.3328.

Full text

Abstract:

Abstract RASA3, a Ras GTPase activating protein, is critical to vertebrate erythropoiesis and megakaryopoiesis. Defective RASA3 in zebrafish and mice results in severe anemia and thrombocytopenia. Indeed, in the mouse model scat (severe combined anemia and thrombocytopenia), a G125V mutation in Rasa3 leads to profound bone marrow failure with characteristics of aplastic anemia. The phenotype is cyclic, and mice alternate between periods of crisis and remission. Previous studies showed that this mutation in Rasa3 causes severely delayed erythroid differentiation at the polychromatophilic stage

APA, Harvard, Vancouver, ISO, and other styles

25

Soni, Shivani, Shashi Bala, Babette Gwynn, Kenneth E. Sahr, Luanne L. Peters, and Manjit Hanspal. "Emp Null Mice Are Non-Viable and Exhibit Erythroid Differentiation Defect." Blood 106, no. 11 (2005): 806. http://dx.doi.org/10.1182/blood.v106.11.806.806.

Full text

Abstract:

Abstract Emp, erythroblast macrophage protein, was originally detected in erythroblasts and macrophages, which form erythroblastic islands during erythropoiesis in the human bone marrow. The physical contact between erythroblasts and macrophages was suggested to promote the terminal maturation of erythroblasts, leading to their enucleation in vitro. To evaluate the function of Emp in vivo, we employed gene targeting studies to develop an Emp(−/−) mouse model. Mouse embryonic stem cells containing a gene-trap insertion in Emp were obtained from BayGenomics. Insertion of the gene-trap vector int

APA, Harvard, Vancouver, ISO, and other styles

26

Camprecióos, Geníis, Xin Zhang, Valentina D'Escamard, et al. "Metabolic Pathways Control Normal and Beta-Thalassemic Erythroid Cell Maturation." Blood 120, no. 21 (2012): 369. http://dx.doi.org/10.1182/blood.v120.21.369.369.

Full text

Abstract:

Abstract Abstract 369 Erythroid cell maturation requires the integration of erythropoietin receptor (EpoR)-mediated signaling pathways and transcriptional programs of erythroid cell proliferation and differentiation largely orchestrated by GATA-1 and its transcriptional partners. Although red blood cells (RBC) purely rely on glycolysis for energy production, and metabolic processes specifically autophagy have been implicated in erythroid maturation, the potential involvement of metabolic pathways in the control of erythroid cell production is not known. Foxo3 transcription factor is a direct t

APA, Harvard, Vancouver, ISO, and other styles

27

Oikonomidou, Paraskevi Rea, Ping La, Ritama Gupta та ін. "Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS". Blood 128, № 22 (2016): 2439. http://dx.doi.org/10.1182/blood.v128.22.2439.2439.

Full text

Abstract:

Abstract The current treatment of β-thalassemia only partially mitigates the phenotype of the disease, making the need for novel therapeutic agents imperative. The investigational drug Luspatercept (ACE-536) is a ligand trap that contains the modified extracellular domain of activin receptor IIB (ACVR2B) and induces red blood cell production in an erythropoietin independent fashion. ACE-536 binds with high affinity to members of the transforming growth factor (TGF) β superfamily and therefore alters activin/GDF signaling through the intracellular SMAD complex. In search of the specific ligands

APA, Harvard, Vancouver, ISO, and other styles

28

Schneider, Rebekka K., Marie E. McConkey, Lisa P. Chu, and Benjamin L. Ebert. "Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency." Blood 124, no. 21 (2014): 1892. http://dx.doi.org/10.1182/blood.v124.21.1892.1892.

Full text

Abstract:

Abstract The 5q-syndrome is a subtype of myelodysplastic syndrome (MDS) with a defined clinical phenotype associated with heterozygous deletion of Chromosome 5q. The RPS14 gene was identified as a critical gene for the erythroid phenotype of the 5q- syndrome using an RNA interference screen. We generated a murine model for conditional, heterozygous inactivation of Rps14 in the bone marrow to investigate the biological basis of del(5q) MDS. To explore the role of Rps14 on hematopoietic stem cell (HSC) function and erythroid differentiation, we generated a mouse model in which Rps14 exons 2-4 ar

APA, Harvard, Vancouver, ISO, and other styles

29

Li, Huihui, Jing Liu, Jianhua Zhang, et al. "Apo-Transferrin Injections Reduce Transferrin Receptor 1 Concentration on Erythroid Precursors and Reverse Ineffective Erythropoiesis In Splenectomized Beta-Thalassemic Mice." Blood 116, no. 21 (2010): 4283. http://dx.doi.org/10.1182/blood.v116.21.4283.4283.

Full text

Abstract:

Abstract Abstract 4283 Beta-thalassemia results from a mutation in the beta-globin gene which leads to ineffective erythropoiesis (IE), shortened red blood cell (RBC) survival, and anemia requiring varying degrees of transfusion-dependence. Our previous data demonstrate that thalassemic (Hbbth1/th1) mice treated with apo-transferrin have more circulating RBCs, each with lower mean corpuscular hemoglobin (MCH), increased hemoglobin, and reversal of splenomegaly. These results suggest that anemia in beta-thalassemia is a consequence of excess intracellular heme in developing erythroblasts. Becau

APA, Harvard, Vancouver, ISO, and other styles

30

Pan, Dao, Theodosia A. Kalfa, Daren Wang, et al. "Change in Expressional Profile of KCl Cotransporter Genes during Human Erythroid Differentiation." Blood 110, no. 11 (2007): 1709. http://dx.doi.org/10.1182/blood.v110.11.1709.1709.

Full text

Abstract:

Abstract Maintenance of cell volume by regulated cation transport is a fundamental cellular process. The KCl cotransporter (KCC) contributes to red blood cell (RBC) volume regulation, especially in reticulocytes. Erythroid K-Cl cotransport activity is increased in sickle cells (SS RBC) and contribute to SS RBC dehydration, which potentiates sickling. Three cation cotransporter genes, SLC12A4 (KCC1), SLC12A6 (KCC3) and SLC12A7 (KCC4), and several splicing variants, mediate KCC activity in non-neuronal tissues. To determine which KCC isoform(s) predominates in human RBC we examined the quantitat

APA, Harvard, Vancouver, ISO, and other styles

31

Sosnina, S. F., A. M. Yurkin, P. V. Okatenko, S. A. Rogacheva, E. A. Gruzdeva, and M. E. Sokolnikov. "Leukemia risk and rate of radiation dose accumulation. Part 2: Comparative analysis of leukocytic indices and dynamics of peripheral blood values in relation to external gamma-exposure dose." Radiatsionnaya Gygiena = Radiation Hygiene 13, no. 2 (2020): 75–88. http://dx.doi.org/10.21514/1998-426x-2020-13-2-75-88.

Full text

Abstract:

The results of a retrospective analysis of leukocytic indices and dynamics of peripheral blood values in relation to external gamma-exposure dose among the personnel of the first atomic production facility in Russia were presented. The study was performed on the basis of the database “Leukemia in the cohort of workers of the Mayak Production Association employed in 1948-1958”. The database contains hematological, clinical and dosimetry information on the two groups of workers: the study group includes individuals with leukemia as the cause of death (n=84); control group includes personnel with

APA, Harvard, Vancouver, ISO, and other styles

32

Wong, Wendy, Jason Merker, Christine Nguyen, William Berquist, Bertil Glader, and Magali J. Fontaine. "Cold Agglutinin Syndrome in Post-Liver Transplant Patients on Tacrolimus." Blood 108, no. 11 (2006): 967. http://dx.doi.org/10.1182/blood.v108.11.967.967.

Full text

Abstract:

Abstract Following liver transplantation, patients require immunosuppressive medications to prevent graft rejection. However, these drugs can have significant side effects including severe anemia. Tacrolimus is now commonly used in pediatrics patients after liver transplantation. Case reports indicate that tacrolimus rarely can cause microangiopathic hemolytic anemia and also hemolytic anemia due to cold reactive IgM antibodies (cold agglutinin disease). We have seen 4 patients with symptomatic cold agglutinins thought to have been triggered by tacrolimus. Four patients, 6 to 26 months post-AB

APA, Harvard, Vancouver, ISO, and other styles

33

Li, Jianping, Fuhong He, Peng Zhang, et al. "ASXL2 Is Required for Normal Hematopoiesis and Loss of asxl2 Leads to Myeloid Malignancies in Mice." Blood 128, no. 22 (2016): 1509. http://dx.doi.org/10.1182/blood.v128.22.1509.1509.

Full text

Abstract:

Abstract Somatic mutations and chromosomal translocations of genes have emerged as major drivers in a range of hematopoietic malignancies. While ASXL1 is mutated in all forms of myeloid malignancies, ASXL2 is specifically mutated in t(8;21) AML patients. ASXL1 and ASXL2 mutations are mutually exclusive in t(8;21) AML. Despite the importance of ASXL2 mutations in clinical, it's role in leukemogenesis remain unknown. In the current study, we sought to dissect the role of ASXL2 in normal hematopoiesis and to identify the molecular mechanisms by which Asxl2 loss contributes to myeloid malignancies

APA, Harvard, Vancouver, ISO, and other styles

34

Peters, Luanne L., Steven L. Ciciotte, E. Ricky Chan, et al. "Positional Cloning of the Mouse Scat Mutation Reveals a Critical Role for RASA3, a Ras GTPase Activating Protein, in Vertebrate Erythropoiesis." Blood 114, no. 22 (2009): 776. http://dx.doi.org/10.1182/blood.v114.22.776.776.

Full text

Abstract:

Abstract Abstract 776 The spontaneous recessive mutation scat (severe combined anemia and thrombocytopenia) arose on the inbred BALB/cBy (BALB) mouse strain. The phenotype of scat is cyclic. All homozygotes are severely anemic and thrombocytopenic at birth. Leukocytes are also significantly depleted (Table). Approximately 13% die during this first “crisis” episode that lasts, on average, until the 9th postnatal day. Remarkably, a spontaneous remission ensues in those surviving the neonatal crisis period wherein all peripheral blood values revert to normal. A second crisis follows, and 94% of t

APA, Harvard, Vancouver, ISO, and other styles

35

Gordon-Smith, Ted. "Red blood cells." Surgery (Oxford) 25, no. 2 (2007): 57–60. http://dx.doi.org/10.1016/j.mpsur.2006.12.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Peter Klinken, S. "Red blood cells." International Journal of Biochemistry & Cell Biology 34, no. 12 (2002): 1513–18. http://dx.doi.org/10.1016/s1357-2725(02)00087-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Rozanova, O. M., T. A. Belyakova, E. N. Smirnova, et al. "Features of the Effects of Exposure to 90–170 MeV Proton Radiation on the Blood-Forming Organs in Mice under Total Irradiation with Proton Pencil Scanning Beam Depending on the Linear Energy Transfer of Particles." Biofizika 69, no. 4 (2024): 895–905. http://dx.doi.org/10.31857/s0006302924040207.

Full text

Abstract:

The effects on induction of cytogenetic damage to mouse bone marrow, generation of reactive oxygen species by whole blood cells, and on the thymus and spleen from exposure of mice to total-body proton radiation before and at the Bragg peak with a dose deposition of 0.1–1.5 Gy were investigated depending on the linear rate of energy loss. It was found that the level of polychromatophilic erythrocytes with micronuclei at all doses of proton radiation at the Bragg peak with the linear energy transfer 2.5 keV/μm was close to that of polychromatophilic erythrocytes with micronuclei for the correspo

APA, Harvard, Vancouver, ISO, and other styles

38

Labie, Dominique. "Red blood cells erythrophagocytosis." Hématologie 18, no. 2 (2012): 138–39. http://dx.doi.org/10.1684/hma.2012.0694.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Palermo, Gregory J., and Joseph R. Bove. "Washed Red Blood Cells." Transfusion 21, no. 6 (2009): 757–58. http://dx.doi.org/10.1111/j.1537-2995.1981.tb03957.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Maslak, P. "Packed Red Blood Cells." ASH Image Bank 2005, no. 0131 (2005): 101277. http://dx.doi.org/10.1182/ashimagebank-2005-101277.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

MRAZIK, MARY JANE, and THOMAS MRAZIK. "ADMINISTERING RED BLOOD CELLS." Nursing 20, no. 5 (1990): 132–34. http://dx.doi.org/10.1097/00152193-199005000-00038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Hampton, David A., Connor Wiles, Loïc J. Fabricant, et al. "Cryopreserved red blood cells are superior to standard liquid red blood cells." Journal of Trauma and Acute Care Surgery 77, no. 1 (2014): 20–27. http://dx.doi.org/10.1097/ta.0000000000000268.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Weiss, L., and U. Geduldig. "Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow." Blood 78, no. 4 (1991): 975–90. http://dx.doi.org/10.1182/blood.v78.4.975.975.

Full text

Abstract:

Abstract Murine hematopoietic bone marrow is heterogenous in respect to bone- lining cells, hematopoiesis, and release of blood cells. In diaphyseal femoral marrow, bone-lining cells are largely osteoblasts, indifferent endosteum, blood cells, and reticular cells. Hematopoiesis is sustained by rather differentiated progenitors, as myelocytes and polychromatophilic erythroblasts. But in sharply restricted loci within trabeculated bone in the distal medial femoral metaphysis, bone-lining cells are dominated by newly discovered fibroblastic, contractile, stromal barrier cells; activated, multilam

APA, Harvard, Vancouver, ISO, and other styles

44

Weiss, L., and U. Geduldig. "Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow." Blood 78, no. 4 (1991): 975–90. http://dx.doi.org/10.1182/blood.v78.4.975.bloodjournal784975.

Full text

Abstract:

Murine hematopoietic bone marrow is heterogenous in respect to bone- lining cells, hematopoiesis, and release of blood cells. In diaphyseal femoral marrow, bone-lining cells are largely osteoblasts, indifferent endosteum, blood cells, and reticular cells. Hematopoiesis is sustained by rather differentiated progenitors, as myelocytes and polychromatophilic erythroblasts. But in sharply restricted loci within trabeculated bone in the distal medial femoral metaphysis, bone-lining cells are dominated by newly discovered fibroblastic, contractile, stromal barrier cells; activated, multilaminar and

APA, Harvard, Vancouver, ISO, and other styles

45

Chabin, I. A., N. A. Podoplelova, and M. A. Panteleev. "Red blood cells contribution in blood coagulation." Pediatric Hematology/Oncology and Immunopathology 21, no. 3 (2022): 136–41. http://dx.doi.org/10.24287/1726-1708-2022-21-3-136-141.

Full text

Abstract:

For a long time, red blood cells have been known to have a procoagulant effect on hemostatic system. This effect was usually ascribed to either general increase of blood viscosity due to increased hematocrit value, RBCs' transport-enhancing effect on platelets adhesion under flow conditions. It is known that red blood cells can have a procoagulant effect on the hemostasis system. This effect is usually explained either by a general increase in blood viscosity due to an increase in hematocrit, or by the effect of red blood cells on the transport of platelets to the vessel wall and their further

APA, Harvard, Vancouver, ISO, and other styles

46

Melland, Cami, and Connie Hintz. "Detecting polyagglutinable red blood cells." Immunohematology 34, no. 3 (2019): 113–17. http://dx.doi.org/10.21307/immunohematology-2018-019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

T.P, Deepa, N. Sai Ahladitha Reddy, K. Jai Santhoshi, Priya M, and Lakshmi N. "Segmentation of Red Blood Cells." International Journal of Computer Sciences and Engineering 6, no. 5 (2018): 641–43. http://dx.doi.org/10.26438/ijcse/v6i5.641643.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Dexter, William W. "Clinical Colloquium – Red Blood Cells." Medicine & Science in Sports & Exercise 38, Supplement (2006): 45. http://dx.doi.org/10.1249/00005768-200605001-00122.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Glazer, James. "Clinical Colloquium – Red Blood Cells." Medicine & Science in Sports & Exercise 38, Supplement (2006): 45. http://dx.doi.org/10.1249/00005768-200605001-00123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Bouchard, Mark P. "Clinical Colloquium – Red Blood Cells." Medicine & Science in Sports & Exercise 38, Supplement (2006): 45. http://dx.doi.org/10.1249/00005768-200605001-00124.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!