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Relevant bibliographies by topics / Polygenic traits / Dissertations / Theses

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Dissertations / Theses on the topic 'Polygenic traits'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Lango, Allen Hana. "The role of common genetic variation in model polygenic and monogenic traits." Thesis, University of Exeter, 2010. http://hdl.handle.net/10871/11714.

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The aim of this thesis is to explore the role of common genetic variation, identified through genome-wide association (GWA) studies, in human traits and diseases, using height as a model polygenic trait, type 2 diabetes as a model common polygenic disease, and maturity onset diabetes of the young (MODY) as a model monogenic disease. The wave of the initial GWA studies, such as the Wellcome Trust Case-Control Consortium (WTCCC) study of seven common diseases, substantially increased the number of common variants associated with a range of different multifactorial traits and diseases. The initia

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2

Rakitsch, Barbara [Verfasser], and Karsten [Akademischer Betreuer] Borgwardt. "Modeling the polygenic architecture of complex traits / Barbara Rakitsch ; Betreuer: Karsten Borgwardt." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197057099/34.

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3

Riffo, Francisco Cubillios. "multi-parent crosses reveal the complex genetic architecture of polygenic traits in yeast." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537694.

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4

Merwood, Andrew. "Exploring the aetiology of ADHD : rater effects, co-occurring traits and polygenic scores." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/exploring-the-aetiology-of-adhd(e7a5d527-95e0-4b47-bc20-05dc23e835b2).html.

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The precise aetiology of attention-deficit/hyperactivity disorder (ADHD) and its association with co-occurring traits remains unclear. Accordingly, the overarching aim of this thesis was to address several ambiguities surrounding the causes and correlates of ADHD. The first of these ambiguities concerns rater effects in twin studies. This was addressed by examining parent, teacher and child self-ratings of ADHD symptoms obtained concurrently using population-based twin data. Results revealed significantly lower heritability for self-ratings than for parent or teacher ratings of ADHD symptoms,

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5

Chan, Ying Leong. "Leveraging genetic association data to investigate the polygenic architecture of human traits and diseases." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11372.

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Many human traits and diseases have a polygenic architecture, where phenotype is partially determined by variation in many genes. These complex traits or diseases can be highly heritable and genome-wide association studies (GWAS) have been relatively successful in the identification of associated variants. However, these variants typically do not account for most of the heritability and thus, the genetic architecture remains uncertain.

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6

Miyake, Takeshi. "STATISTICAL GENETIC EVALUATION OF ANIMALS FOR QUANTITATIVE TRAITS UNDER POLYGENIC MODEL AND MIXED INHERITANCE MODEL." Kyoto University, 1999. http://hdl.handle.net/2433/181392.

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7

Krapohl, Eva Maria Laura. "Multi-variable approaches to polygenic trait prediction." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/multivariable-approaches-to-polygenic-trait-prediction(1e69a4a3-f89b-4646-980e-02031d5c23d3).html.

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Robust evidence for the polygenicity and genetic correlations of complex traits across the phenome suggests both the necessity of polygenic instruments and the value of multi-trait prediction models. This thesis used multi-variable approaches in four papers and along two main threads: Multi-variable approaches to trait prediction A primary goal of polygenic scores, which aggregate effects of trait-associated variants discovered in genome-wide association studies (GWAS), is to estimate individual-specific genetic propensities to predict trait variation. This is typically achieved using one poly

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8

Reavey, Caitlin Teresa. "Analysis of Transcription Activation Distance as a Polygenic Trait in Saccharomyces cerevisiae." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11202.

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Much of the eukaryotic transcriptional machinery is conserved from yeast to human. However, the distance over which transcriptional activation can occur differs between Saccharomyces cerevisiae and metazoans. In S. cerevisiae, the upstream activating sequence (UAS) is generally found within 300 base pairs of the transcription start site; when the UAS is moved too far away, activation no longer occurs. In contrast, metazoan enhancers can activate from as far as 100 kilobases from the start site. In past work, our lab identified five genes that, when mutant, allow transcription activation to

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9

Muiños, Gimeno Margarita. "Analysis of genetic variation in microrna-mediated regulation and the susceptibility to anxiety disorders." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7192.

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We have investigated genetic variation in microRNA-mediated regulation as a susceptibility factor for anxiety disorders following two different approaches. We first studied two isoforms of the candidate gene NTRK3 by re-sequencing its different 3'UTRs in patients with Panic (PD) and Obsessive Compulsive disorders (OCD) as well as controls. Two rare variants that altered microRNA-mediated regulation were identified in PD. Conversely, association of a common SNP with OCD hoarding subtype was found. Moreover, we have also studied a possible involvement of microRNAs in anxiety disorders. Consequen

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10

Cantet, Mélissa. "Variation phénotypique de la résistance quantitative à Phytophthora capsici dans la diversité naturelle du piment, et diversité moléculaire et profil d'évolution du QTL majeur Pc5.1." Electronic Thesis or Diss., Montpellier, SupAgro, 2013. http://www.theses.fr/2013NSAM0006.

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L'utilisation de variétés présentant des résistances quantitatives polygéniques est une pratique respectueuse de l'environnement et potentiellement durable pour lutter contre les bioagresseurs. Les résistances quantitatives sont cependant mal connues et encore peu exploitées. Via l'étude de l'interaction Capsicum spp. / Phytophthora capsici, les objectifs sont de (i) caractériser la diversité naturelle de l'hôte pour le phénotype quantitatif de résistance, (ii) décrire la diversité au QTL Pc5.1, déterminant majeur de la résistance, conservé chez les géniteurs et efficace à large spectre, et (i

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11

Morra, Erica, and Lisa Zenker. "Chapter 1: In Search of Innate Leadership : Discovering, Evaluating and Understanding Innateness." Thesis, Linnéuniversitetet, Institutionen för organisation och entreprenörskap (OE), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34622.

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Every individual is born with different natural competencies that can be honed by both voluntary and involuntary environmental stimuli. The response our genotype decides to make, if any, towards those stimuli, determines how well our competencies develop. Each person’s coding and variations of genes will result in unique qualities in their phenotype, or physical structure. As a result, a person has various traits that are displayed through their behavior. DNA is genetically shown to express itself through traits by up to 75%. This leaves a sort of buffer of around 25%. This region is available

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12

Cantet, Mélissa. "Variation phénotypique de la résistance quantitative à Phytophthora capsici dans la diversité naturelle du piment, et diversité moléculaire et profil d'évolution du QTL majeur Pc5.1." Thesis, Montpellier, SupAgro, 2013. http://www.theses.fr/2013NSAM0006.

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L'utilisation de variétés présentant des résistances quantitatives polygéniques est une pratique respectueuse de l'environnement et potentiellement durable pour lutter contre les bioagresseurs. Les résistances quantitatives sont cependant mal connues et encore peu exploitées. Via l'étude de l'interaction Capsicum spp. / Phytophthora capsici, les objectifs sont de (i) caractériser la diversité naturelle de l'hôte pour le phénotype quantitatif de résistance, (ii) décrire la diversité au QTL Pc5.1, déterminant majeur de la résistance, conservé chez les géniteurs et efficace à large spectre, et (i

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13

Barthélémy, Clément. "Adaptation génétique et détection de la sélection dans le cadre d'évolutions expérimentales." Thesis, La Rochelle, 2020. http://www.theses.fr/2020LAROS013.

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L'adaptation est un concept au cœur de la théorie de l'évolution par sélection naturelle. Elle désigne à la fois le processus qui permet l'ajustement des caractères phénotypiques d'un être vivant aux conditions environnementales extérieures et l'état résultant de ce processus. Dans ce cadre, l'adaptation génétique représente l'ensemble des déterminants moléculaires de l'adaptation, c'est-à-dire l'ensemble des mécanismes permettant l'adaptation des espèces à l'échelle moléculaire. Pour étudier les procédés évolutifs à l'œuvre durant l'adaptation on peut étudier l'évolution d'une population expé

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14

Bae, Harold Taehyun. "Understanding the genetic basis of complex polygenic traits through Bayesian model selection of multiple genetic models and network modeling of family-based genetic data." Thesis, 2014. https://hdl.handle.net/2144/15337.

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The global aim of this dissertation is to develop advanced statistical modeling to understand the genetic basis of complex polygenic traits. In order to achieve this goal, this dissertation focuses on the development of (i) a novel methodology to detect genetic variants with different inheritance patterns formulated as a Bayesian model selection problem, (ii) integration of genetic data and non-genetic data to dissect the genotype-phenotype associations using Bayesian networks with family-based data, and (iii) an efficient technique to model the family-based data in the Bayesian framework. I

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15

Satagopan, Jaya Madhangi. "A Markov Chain Monte Carlo approach to detect polygene loci for complex traits." 1995. http://catalog.hathitrust.org/api/volumes/oclc/34486719.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1995.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 135-145).

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16

(13991187), Joseph W. Daley. "Mixed model methods for quantitative trait loci estimation in crosses between outbred lines." Thesis, 2003. https://figshare.com/articles/thesis/Mixed_model_methods_for_quantitative_trait_loci_estimation_in_crosses_between_outbred_lines/21376767.

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<p>Methodology is developed for Quantitative Trait Loci (QTL) analysis in F<sub>2</sub> and backcross designed experiments between outbred lines using a mixed model framework through the modification of segment mapping techniques. Alleles are modelled in the F<sub>1</sub> and parental generations allowing the estimation of individual additive allele effects while accounting for QTL segregation within lines as well as differences in mean QTL effects between lines.</p> <p>Initially the theory, called F<sub>1</sub> origin mapping, is developed for a single trait scenario involving possible multip

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17

Payne, Pavel. "Role genetické variance ve speciaci." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312776.

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Sympatric speciation has received much attention both empirically and theoretically. However, the contribution of sympatric speciation to biodiversity remains unclear. One piece missing from the speciation puzzle is the plausibility of sympatric ecological divergence of species through adaptation in polygenic traits. I consider an environment consisting of two niches, where one value of the trait is advantageous in only one niche, and vice versa. The selection regime is described by a trade-off in viabilities between the niches. These polygenic traits can, and often do, involve epistatic inter

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18

Gillis, Robert Francis Fraser. "Finding genetic elements that head to the autistic phenotype." Thèse, 2007. http://hdl.handle.net/1866/7622.

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