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Journal articles on the topic 'Polygodial'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Lunde, Christopher S., and Isao Kubo. "Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae." Antimicrobial Agents and Chemotherapy 44, no. 7 (2000): 1943–53. http://dx.doi.org/10.1128/aac.44.7.1943-1953.2000.

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ABSTRACT The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae. In an acidification assay, polygodial completely suppressed the glucose-induced decrease in external pH at 3.13 μg/ml, the same as the fungicidal concentration. Acidification occurs primarily through the proton-pumping action of the plasma membrane ATPase, Pma1p. Surprisingly, this ATPase was not directly inhibited by polygodial. In contrast, the two other membrane-bound ATPases in yeast were found to be susceptible to the compound. The mitochondrial AT

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2

Kipanga, Purity N., Liesbeth Demuyser, Johannes Vrijdag, et al. "Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae." International Journal of Molecular Sciences 22, no. 11 (2021): 5756. http://dx.doi.org/10.3390/ijms22115756.

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Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains that were hypersensitive and 47 that were highly resistant to polygodial treatment. Among the hypersensitive strains, an enrichment was found for genes required for vacuolar acidification, amino acid biosynthesis, nucleosome mobilization, the transcr

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3

Marín, Víctor, Cecilia Villegas, Ayorinde Víctor Ogundele, et al. "Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway." Molecules 30, no. 7 (2025): 1555. https://doi.org/10.3390/molecules30071555.

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Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relevant pathways for identifying anti-inflammatory molecules. In this study, polygodial and isotadeonal, two drimane sesquiterpene dialdehydes, were isolated from Drimys winteri, a medicinal tree of the Mapuche people in Chile. Isotadeonal, or epi-polygodial, was obtained from polygodial by epimerization in basic media (60% yield, Na2CO3, r/t, 24 h). Both sesquite

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4

Kutney, James P., Yong-Huang Chen, and Steven J. Rettig. "The chemistry of thujone. XVIII Homothujone and its derivatives." Canadian Journal of Chemistry 74, no. 5 (1996): 666–76. http://dx.doi.org/10.1139/v96-072.

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The monoterpene thujone (1) is ring expanded regioselectively to provide homothujone (4) in order to explore its potential as a chiral starting material. Stereoselective Robinson annulation of homothujone provides an enone intermediate (5), further derivatization of which was undertaken to furnish functionalized naphthalenones useful for synthesis of the antifeedant (−)-polygodial and the ambergris fragrance (−)-Ambrox®. Key words: thujone, homothujone, synthesis, naphthalenones, polygodial, Ambrox.

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5

Kubo, Isao, Ken'ichi Fujita, and Sang Hwa Lee. "Antifungal Mechanism of Polygodial." Journal of Agricultural and Food Chemistry 49, no. 3 (2001): 1607–11. http://dx.doi.org/10.1021/jf000136g.

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6

Kubo, Isao, and Makoto Taniguchi. "Polygodial, an Antifungal Potentiator." Journal of Natural Products 51, no. 1 (1988): 22–29. http://dx.doi.org/10.1021/np50055a002.

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7

Kubo, Isao, Ken-ichi Fujita, Sang Hwa Lee, and Tae Joung Ha. "Antibacterial activity of polygodial." Phytotherapy Research 19, no. 12 (2005): 1013–17. http://dx.doi.org/10.1002/ptr.1777.

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8

Kutney, James P., Krystyna Piotrowska, Yong-Huang Chen, Kwok-Ping Norman Cheng, Zhenyong Gao, and Steven J. Rettig. "The chemistry of thujone. XV. A versatile route to antifeedants of the polygodial family." Canadian Journal of Chemistry 68, no. 10 (1990): 1698–708. http://dx.doi.org/10.1139/v90-264.

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Utilizing thujone-derived intermediates, efficient routes to the natural polygodial family of antifeedants as well as novel analogues within this family are described. One of the key features of this study involves the insertion of an oxygen function into a tertiary carbon center adjacent to a cyclopropane ring system thus providing convenient intermediates for subsequent elaboration. An interesting ring expansion of five-membered to six-membered ring systems by means of tri-n-butyltin hydride is also described. Keywords: antifeedants, polygodial, thujone.

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9

Asakawa, Yoshinori, Masako Sekita, and Toshihiro Hashimoto. "Biotransformation of Bicyclic Sesqui- and Diterpene 1,2-dials and Their Derivatives by the Fungus, Aspergillus niger." Natural Product Communications 13, no. 8 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300802.

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Microbial biotransformation of naturally occurring pungent sesquiterpene 1,2-dials, polygodial and cinnamodial, and a diterpene 1,2-dial, sacculatal as well as their tetrahydro derivatives was carried out by using Aspergillus niger. The pungent polygodial and sacculatal are toxic against A. niger not to produce any metabolites while A. niger biotransformed cinnamodial to the lactonized products in small amount. On the other hands, the dihydroxy derivatives of the former two dialdehydes were bioconverted by the same fungus to give hydroxy-, oxo-, carboxylic- and epoxy-products. The stereostruct

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10

Cahill, Patrick L., Javier Atalah, Andrew I. Selwood, and Jeanne M. Kuhajek. "Metamorphosis of the invasive ascidianCiona savignyi: environmental variables and chemical exposure." PeerJ 4 (February 25, 2016): e1739. http://dx.doi.org/10.7717/peerj.1739.

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In this study, the effects of environmental variables on larval metamorphosis of the solitary ascidianCiona savignyiwere investigated in a laboratory setting. The progression of metamorphic changes were tracked under various temperature, photoperiod, substrate, larval density, and vessel size regimes. Metamorphosis was maximised at 18 °C, 12:12 h subdued light:dark, smooth polystyrene substrate, and 10 larvae mL−1in a twelve-well tissue culture plate. Eliminating the air-water interface by filling culture vessels to capacity further increased the proportion of metamorphosed larvae; 87 ± 5% of

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11

Montenegro, Iván, Rolando Pazmiño, Ileana Araque, et al. "Antimicrobial Activity of Drimanic Sesquiterpene Compounds from Drimys winteri against Multiresistant Microorganisms." Molecules 29, no. 12 (2024): 2844. http://dx.doi.org/10.3390/molecules29122844.

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In this work, a group of ten sesquiterpene drimanes, including polygodial (1), isopolygodial (2), and drimenol (3) obtained from the bark of Drimys winteri F. and seven synthetic derivatives, were tested in vitro against a unique panel of bacteria, fungi, and oomycetes with standardized procedures against bacterial strains K. pneumoniae, S. tiphy, E. avium, and E. coli. The minimum inhibitory concentrations and bactericidal activities were evaluated using standardized protocols. Polygodial (1) was the most active compound, with MBC 8 μg/mL and MIC 16 μg/mL in E. avium; MBC 16 μg/mL and MIC 32

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12

Asakawa, Yoshinori, Agnieszka Ludwiczuk, Liva Harinantenaina, et al. "Distribution of Drimane Sesquiterpenoids and Tocopherols in Liverworts, Ferns and Higher Plants: Polygonaceae, Canellaceae and Winteraceae Species." Natural Product Communications 7, no. 6 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700601.

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The liverwort, Porella vernicosa complex produces a very hot tasting polygodial, a drimane-type sesquiterpene dialdehyde. The same compound has been isolated from two ferns, Thelypteris hispidula and Blechnum fluviatile, as well as from the higher plants Polygonum hydropiper, P. hydropiper f purpurascens (Polygonaceae), Cinnamosma, Caspicodendron, Canella and Warburgia species (Canellaceae), and Pseudowintera colorata, Tasmannia lanceolata, Drimys and Zygogynum species (Winteraceae). In addition, the liverworts and higher plants which elaborate polygodial and its related pungent drimane dials

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13

Al-Asmari, Fahad, Saleha Akter, Ram Mereddy, and Yasmina Sultanbawa. "Investigating the Efficacy of Tasmannia lanceolata Extract in Inactivating Fungi and Prolonging the Shelf Life of Date Fruit." Foods 11, no. 17 (2022): 2631. http://dx.doi.org/10.3390/foods11172631.

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Date palm (Phoenix dactylifera L.) is one of the world’s oldest cultivated plants. Post-harvest losses of date palm due to fungal contamination reached up to 50% of the total production. This study aimed to investigate the potential of the extract of Tasmanian pepper leaf (TPL) and the non-thermal treatment of photosensitization mediated by curcumin in reducing the fungal contamination and enhancing the shelf life of date palm. In the in vivo storage study, the dates were treated with three different concentrations of TPL extract 12.5, 25, and 50 µg/mL and stored at 30 °C. The findings obtaine

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14

Moreno-Osorio, Luis, Manuel Cortés, Verónica Armstrong, María Bailén, and Azucena González-Coloma. "Antifeedant Activity of Some Polygodial Derivatives." Zeitschrift für Naturforschung C 63, no. 3-4 (2008): 215–20. http://dx.doi.org/10.1515/znc-2008-3-410.

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Polygodial (1) and its derivatives acetal 2 (propylene) and 3 (ethylene) were prepared and their antifeedant activity and toxic effects evaluated on several insect species with different feeding ecologies (Spodoptera littoralis, Leptinotarsa decemlineata, Myzus persicae and Rhopalosiphum padi) along with that of polygonone (4). We also tested their selective cytotoxic effects on insect-derived (Spodoptera frugiperda ovarian Sf9 cells) and mammalian Chinese hamster ovary (CHO) cells. The antifeedant activity of these compounds was consistent with the proposed mode of action for antifeedant drim

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15

Razmilic, Iván, José López, and Jorge Sierra. "An Alternative Partial Synthesis of (-)-Polygodial." Synthetic Communications 17, no. 1 (1987): 95–103. http://dx.doi.org/10.1080/00397918708063908.

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16

Cahill, P. L., and J. M. Kuhajek. "Polygodial: a contact active antifouling biocide." Biofouling 30, no. 9 (2014): 1035–43. http://dx.doi.org/10.1080/08927014.2014.966305.

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17

Just, Jeremy, Timothy B. Jordan, Brett Paull, Alex C. Bissember, and Jason A. Smith. "Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis." Organic & Biomolecular Chemistry 13, no. 46 (2015): 11200–11207. http://dx.doi.org/10.1039/c5ob01573a.

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Polygodial, was efficiently extracted and isolated in gram-scale quantities (3.3% w/w) from Tasmannia lanceolata (Tasmanian native pepper) using a pressurised hot water extraction (PHWE) technique that utilises an unmodified household espresso machine.

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18

Cullmann, Frank, and Hans Becker. "Sesquiterpenoids from the Liverwort Porella canariensis." Zeitschrift für Naturforschung C 54, no. 3-4 (1999): 151–55. http://dx.doi.org/10.1515/znc-1999-3-402.

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From the liverwort Porella canariensis, collected in Madeira, Portugal, nine pinguisanes, four drimanes, including the pungent polygodial, two germacranes, and two aromadendranes were isolated. The major compounds were the arom adendrane ent-cyclocolorenone and the nor-pinguisane norpinguisone. Three hydrocarbons were isolated by low temperature column chrom atography. One germacrane and one pinguisane proved to be new natural products.

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19

Wilson, M. D., R. C. Menary, and D. C. Close. "Plant nutrition, growth and polygodial production ofTasmannia lanceolata." Acta Horticulturae, no. 1125 (October 2016): 377–82. http://dx.doi.org/10.17660/actahortic.2016.1125.49.

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20

Kubo, Isao, and Masaki Himejima. "Anethole, a synergist of polygodial against filamentous microorganisms." Journal of Agricultural and Food Chemistry 39, no. 12 (1991): 2290–92. http://dx.doi.org/10.1021/jf00012a040.

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21

Santos, Vagner Rodrigues, Livia SâmaraFranciele De Souza Pinto, Bruno César De Borges, and Isao Kubo. "DRUG ENHANCEMENT, SYNERGISM AND ANTIFUNGAL ACTIVITY OF MICONAZOLE ASSOCIATED POLYGODIAL AGAINST CANDIDA ALBICANS." International Journal of Research -GRANTHAALAYAH 5, no. 11 (2017): 95–101. http://dx.doi.org/10.29121/granthaalayah.v5.i11.2017.2332.

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Miconazole has low toxicity, however, there is a high incidence resistance of Candida sp. In the search for new drugs or improve existing ones, the originating products of medicinal plants has been the target of constant studies. The aim of this work was to verifyinvitrosynergismand antifungal activity of miconazole associated with poligodial. Miconazole (MCZ) and Poligodial (P) were dissolved in dimethylsulfoxide (DMSO) 1% done successive dilutions of each product ranging from 25mg to 0,19mg/mL (Polygodial)(10-1 to 10-9mg / ml); 14mg to 0,10mg/mL (miconazole). Antifungal test were based by CL

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22

Purushotham, N., E. E. Jones, J. Monk, and H. J. Ridgway. "Antimicrobial potential of bacterial endophytes that inhabit New Zealands medicinal plant Pseudowintera colorata." New Zealand Plant Protection 68 (January 8, 2015): 444. http://dx.doi.org/10.30843/nzpp.2015.68.5851.

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Medicinal plants are valued for the naturally bioactive compounds they produce International research has demonstrated that these plants contain endophytic microorganisms that through close interaction with the plants physiology contribute to the production of host metabolites either directly or via involvement in biochemical pathways Some endophytes can produce bioactive compounds that are either the same or similar to those originating from their host plants Pseudowintera colorata (horopito or NZ pepper tree) an endemic New Zealand plant used in traditional Maori medicine (rongo257;) is reco

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23

Inocente, Nguyen, Manwill, et al. "Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (Cinnamosma sp.) Extracts and Drimane-Type Sesquiterpenes against Aedes aegypti Mosquitoes." Insects 10, no. 11 (2019): 373. http://dx.doi.org/10.3390/insects10110373.

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The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus Cinnamosma (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of Cinnamosma sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito Aedes aegypti. We show that the bark and root extracts, which contain a higher abundance of drimane

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24

Umehara, Eric, Rayssa A. Cajas, Gabriel B. Conceição, et al. "In Vitro and In Vivo Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from Drimys brasiliensis Branches." Molecules 30, no. 2 (2025): 267. https://doi.org/10.3390/molecules30020267.

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In the present study, the hexane extract from branches of Drimys brasiliensis (Winteraceae) displayed potent activity against Schistosoma mansoni parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition to the previously reported bioactive sesquiterpene 3,6-epidioxy-bisabola-1,10-diene, two chemically related drimane sesquiterpenes—polygodial (1) and 9-deoxymuzigadial (2). The anti-S. mansoni effects for compounds 1 and 2 were determined in vitro, with compound 1 demonstrating significant potency (EC50 value of 10 μM for both male and female

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25

Marín, Víctor, Bryan Bart, Nicole Cortez, et al. "Drimane Sesquiterpene Aldehydes Control Candida Yeast Isolated from Candidemia in Chilean Patients." International Journal of Molecular Sciences 23, no. 19 (2022): 11753. http://dx.doi.org/10.3390/ijms231911753.

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Drimys winteri J.R. (Winteraceae) produce drimane sesquiterpenoids with activity against Candida yeast. In this work, drimenol, polygodial (1), isotadeonal (2), and a new drimane α,β-unsaturated 1,4-dialdehyde, named winterdial (4), were purified from barks of D. winteri. The oxidation of drimenol produced the monoaldehyde drimenal (3). These four aldehyde sesquiterpenoids were evaluated against six Candida species isolated from candidemia patients in Chilean hospitals. Results showed that 1 displays fungistatic activity against all yeasts (3.75 to 15.0 µg/mL), but irritant effects on eyes and

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26

Vagner, Rodrigues Santos, Sâmara Franciele de Souza Pinto Livia, César de Borges Araújo e. Ribeiro Bruno, and IsaoKubo. "DRUG ENHANCEMENT, SYNERGISM AND ANTIFUNGAL ACTIVITY OF MICONAZOLE ASSOCIATED POLYGODIAL AGAINST CANDIDA ALBICANS." International Journal of Research - Granthaalayah 5, no. 11 (2017): 95–101. https://doi.org/10.5281/zenodo.1068235.

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Miconazole has low toxicity, however, there is a high incidence resistance of <em>Candida</em> sp. In the search for new drugs or improve existing ones, the originating products of medicinal plants has been the target of constant studies. The aim of this work was to verify<em>in vitro</em>synergism and antifungal activity of miconazole associated with poligodial. Miconazole (MCZ) and Poligodial (P) were dissolved in dimethylsulfoxide (DMSO) 1% done successive dilutions of each product ranging from 25mg to 0,19mg/mL (Polygodial)(10<sup>-1</sup> to 10<sup>-9</sup>mg / ml); 14mg to 0,10mg/mL (mic

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27

Read, Chris, and Robert Menary. "Leaf Extract and Polygodial Yield inTasmannla lanceolata(Poir.) A.C.Smith." Journal of Essential Oil Research 13, no. 5 (2001): 348–50. http://dx.doi.org/10.1080/10412905.2001.9712229.

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28

TANIGUCHI, Makoto, Yoshihisa YANO, Etsuo TADA, et al. "Mode of action of polygodial. An antifungal sesquiterpene dialdehyde." Agricultural and Biological Chemistry 52, no. 6 (1988): 1409–14. http://dx.doi.org/10.1271/bbb1961.52.1409.

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29

Taniguchi, Makoto, Yoshihisa Yano, Etsuo Tada, et al. "Mode of Action of Polygodial, an Antifungal Sesquiterpene Dialdehyde." Agricultural and Biological Chemistry 52, no. 6 (1988): 1409–14. http://dx.doi.org/10.1080/00021369.1988.10868863.

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30

Gonçalves, Giulia Elisa G., Thiago R. Morais, João Henrique G. Lago, and Luciano Caseli. "Incorporation of polygodial in Langmuir films of selected lipids." Thin Solid Films 669 (January 2019): 19–28. http://dx.doi.org/10.1016/j.tsf.2018.10.025.

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31

Dasari, Subramanyam, Angela Lincy Prem Antony Samy, Parnal Narvekar, et al. "Polygodial analog induces apoptosis in LNCaP prostate cancer cells." European Journal of Pharmacology 828 (June 2018): 154–62. http://dx.doi.org/10.1016/j.ejphar.2018.03.029.

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32

Forsby, A., M. Nathanson, H. Hasanvan, and E. Walum. "Polygodial Inhibits Carbachol-induced Muscarinic Acetylcholine Receptor Signal Transduction." Toxicology in Vitro 12, no. 5 (1998): 585. http://dx.doi.org/10.1016/s0887-2333(98)00041-1.

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33

Gerard, P. J., N. B. Perry, L. D. Ruf, and L. M. Foster. "Antifeedant and insecticidal activity of compounds fromPseudowintera colorata(Winteraceae) on the webbing clothes moth,Tineola bisselliella(Lepidoptera: Tineidae) and the Australian carpet beetle,Anthrenocerus australis(Coleoptera: Dermestidae)." Bulletin of Entomological Research 83, no. 4 (1993): 547–52. http://dx.doi.org/10.1017/s0007485300039973.

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AbstractExtracts of the leaves of the New Zealand native treePseudowintera colorata(Raoul) showed insecticidal and antifeedant activity against the webbing clothes moth,Tineola bisselliella(Hummel), and antifeedant activity against the Australian carpet beetle,Anthrenocerus australis(Hope). Assay-directed fractionation showed that two sesquiterpene dialdehydes, polygodial and 9-deoxymuzigadial, were responsible for these activities. Both compounds had similar antifeedant and insecticidal activity at rates from 3 to 0.4 mg/g wool in bioassays.

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34

Muñoz, Orlando M., Juan D. Maya, Jorge Ferreira, et al. "Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity." Zeitschrift für Naturforschung C 68, no. 5-6 (2013): 198–202. http://dx.doi.org/10.1515/znc-2013-5-605.

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The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 μg/mL) was purifi ed and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T. cruzi with IC50 values of 27.9 and 25.1 μM, respectively.

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35

Kubo, I. "ANETHOLE, A SYNERGIST OF POLYGODIAL AND WARBURGANAL AGAINST CANDIDA ALBICANS." Acta Horticulturae, no. 332 (August 1993): 191–98. http://dx.doi.org/10.17660/actahortic.1993.332.25.

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36

Gerard, P. J., L. D. Ruf, N. B. Perry, and L. B. Foster. "Insecticidal properties of the terpenoids polygodial, 9-deoxymuzigadial and azadirachtin." Proceedings of the New Zealand Plant Protection Conference 45 (January 8, 1992): 239–42. http://dx.doi.org/10.30843/nzpp.1992.45.11269.

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37

Taniguchi, Makoto, Yoshihisa Yano, Kazuhiko Motoba, et al. "Polygodial-induced Sensitivity to Rifampicin and Actinomycin D ofSaccharomyces cerevisiae." Agricultural and Biological Chemistry 52, no. 7 (1988): 1881–83. http://dx.doi.org/10.1080/00021369.1988.10868929.

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38

Mendes, Gilboé L., Adair R. S. Santos, Angela Malheiros, Valdir Cechinel Filho, Rosendo A. Yunes, and João B. Calixto. "Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial." Journal of Pharmacology and Experimental Therapeutics 292, no. 1 (2000): 164–72. https://doi.org/10.1016/s0022-3565(24)35273-5.

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39

Muñoz-Concha, Diego, Hermine Vogel, Rosendo Yunes, Iván Razmilic, Louisiane Bresciani, and Angela Malheiros. "Presence of polygodial and drimenol in Drimys populations from Chile." Biochemical Systematics and Ecology 35, no. 7 (2007): 434–38. http://dx.doi.org/10.1016/j.bse.2006.10.019.

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40

Andres, M. I., A. Forsby, and E. Walum. "Polygodial-induced noradrenaline release in human neuroblastoma SH-SY5Y cells." Toxicology in Vitro 11, no. 5 (1997): 509–11. http://dx.doi.org/10.1016/s0887-2333(97)00038-6.

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41

Maslivetc, Vladimir, Breana Laguera, Sunena Chandra, et al. "Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets." International Journal of Molecular Sciences 22, no. 20 (2021): 11256. http://dx.doi.org/10.3390/ijms222011256.

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In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- and γ,δ-unsaturated ester analogues of polygodial and ophiobolin A, compounds capable of pyrrolylation of primary amines and demonstrating double-digit micromolar antiproliferative potencies in cancer cells. In the current work, we synthesized dimeric and trimeric variants of such compounds in an effort to discover compounds that could crosslink biological primary amine containing targets. We showed that such compounds retain th

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42

Paz, Cristian, Gerardo Cárcamo, Mario Silva, José Becerra, Homero Urrutia, and Katherine Sossa. "Drimendiol, A Drimane Sesquiterpene with Quorum Sensing Inhibition Activity." Natural Product Communications 8, no. 2 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800201.

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Quorum sensing (QS) is a regulatory mechanism that enables bacteria to make collective decisions such as an increase in virulence factors and biofilm production. Inhibitors of QS are important research tools in the discovery of new potential anti-bacterial agents. Polygodial, drimenol and drimendiol are drimane sesquiterpenoids isolated from Drimys winteri, a Chilean native tree. Their QS activity, when tested on Chromobacterium violaceum ATCC 12472, showed that drimendiol is an inhibitor of QS, decreasing violaceine production in C. violaceum and decreasing biofilm formation of Pseudomonas sy

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Alves, Tânia Maria de Almeida, Fabiane Lacerda Ribeiro, Helmut Kloos, and Carlos Leomar Zani. "Polygodial, the fungitoxic component from the Brazilian medicinal plant Polygonum punctatum." Memórias do Instituto Oswaldo Cruz 96, no. 6 (2001): 831–33. http://dx.doi.org/10.1590/s0074-02762001000600016.

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TANIGUCHI, Makoto, Yoshihisa YANO, Kazuhiko MOTOBA, et al. "Polygodial-induced sensitivity to rifampicin and actinomycin D of Saccharomyces cerevisiae." Agricultural and Biological Chemistry 52, no. 7 (1988): 1881–83. http://dx.doi.org/10.1271/bbb1961.52.1881.

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Banthorpe, Derek V., Charles J. W. Brooks, Jacqueline T. Brown, Graham J. Lappin, and George S. Morris. "Synthesis and accumulation of polygodial by tissue cultures of Polygonum hydropiper." Phytochemistry 28, no. 6 (1989): 1631–33. http://dx.doi.org/10.1016/s0031-9422(00)97814-2.

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Mori, Kenji, and Hidenori Watanabe. "Synthesis of both the enantiomers of polygodial, an insect antifeedant sesouiterpene." Tetrahedron 42, no. 1 (1986): 273–81. http://dx.doi.org/10.1016/s0040-4020(01)87428-7.

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Forsby, Anna, and Erik Walum. "Polygodial induces inositol phosphate turnover in human neuroblastoma SH-SY5Y cells." Neuroscience Letters 217, no. 1 (1996): 50–54. http://dx.doi.org/10.1016/0304-3940(96)13028-7.

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van Beek, Teris A., Nicole van Dam, Aede De Groot, Threes A. M. Geelen, and Linus H. W. van der Plas. "Determination of the sesquiterpene dialdehyde polygodial by high-pressure liquid chromatography." Phytochemical Analysis 5, no. 1 (1994): 19–23. http://dx.doi.org/10.1002/pca.2800050106.

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Hagendoorn, Marc J. M., Threes A. M. Geelen, Teris A. Beek, Diaan C. L. Jamar, Frans A. A. Tetteroo, and Linus H. W. Plas. "Occurrence of polygodial in plant organs and tissue culture of Polygonum hydropiper." Physiologia Plantarum 92, no. 4 (1994): 595–600. http://dx.doi.org/10.1111/j.1399-3054.1994.tb03028.x.

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Hagendoorn, Marc J. M., Threes A. M. Geelen, Teris A. van Beek, Diaan C. L. Jamar, Fans A. A. Tetteroo, and Linus H. W. van der Plas. "Occurrence of polygodial in plant organs and tissue culture of Polygonum hydropiper." Physiologia Plantarum 92, no. 4 (1994): 595–600. http://dx.doi.org/10.1034/j.1399-3054.1994.920408.x.

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