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Journal articles on the topic 'Polyhexanide'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Piątkowska, Elżbieta, Justyna Paleczny, Karolina Dydak, and Krzysztof Letachowicz. "Antimicrobial activity of hemodialysis catheter lock solutions in relation to other compounds with antiseptic properties." PLOS ONE 16, no. 10 (2021): e0258148. http://dx.doi.org/10.1371/journal.pone.0258148.

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Proper protection of vascular access after haemodialysis is one of the key measures for the prevention of catheter-related infections. Various substances with bactericidal and anticoagulant properties are used to fill catheters, but due to the unsatisfactory clinical effects and occurrence of adverse reactions, the search for new substances is still ongoing. In the present paper, we compared the in vitro antimicrobial activity of solutions used for tunnelled catheter locking (taurolidine, trisodium citrate) and solutions of substances that could potentially be used for this purpose (sodium bic

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Wattanaploy, Saruta, Kusuma Chinaroonchai, Nantaporn Namviriyachote, and Pornprom Muangman. "Randomized Controlled Trial of Polyhexanide/Betaine Gel Versus Silver Sulfadiazine for Partial-Thickness Burn Treatment." International Journal of Lower Extremity Wounds 16, no. 1 (2017): 45–50. http://dx.doi.org/10.1177/1534734617690949.

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Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within

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Khabadze, Zurab, Yulia Generalova, and Oleg Mordanov. "Effect of a Polyhexanide-Based Antiseptic Composition on Dentin Microhardness and Mechanical Properties: An In Vitro Study." Materials 18, no. 12 (2025): 2900. https://doi.org/10.3390/ma18122900.

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The effect of root canal irrigants on the mechanical properties of dentin is crucial in endodontic treatment planning. While antiseptics such as sodium hypochlorite and EDTA are widely used, their potential to weaken dentin structure remains a concern. Polyhexanide-based formulations may offer a safer alternative. To assess the impact of a polyhexanide-based antiseptic composition, compared to standard irrigants, on the microhardness, Young’s modulus, and elastic deformation energy of dentin. Sixty extracted human teeth were sectioned and polished to prepare dentin samples. Baseline measuremen

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Khabadze, Z. S., D. S. Nazarova, A. A. Kulikova, Yu A. Generalova, E. S. Shilyaeva, and A. P. Kotelnikova. "Polyhexanide as a new antiseptic composition for a dentist." Endodontics Today 19, no. 4 (2021): 306–9. http://dx.doi.org/10.36377/1683-2981-2021-19-4-306-309.

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Aim. To assess systematically the available scientific evidence about clinical response of using polyhexanide as an antiseptic agent in medicine and dentistry. The properties of polyhexanide – excellent antimicrobial activity, chemical stability and low toxicity – have been studied.

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Núñez-Moral, M., E. Sánchez-Álvarez, I. González-Díaz, et al. "Exit-Site Infection of Peritoneal Catheter is Reduced by the Use of Polyhexanide. Results of a Prospective Randomized Trial." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 34, no. 3 (2014): 271–77. http://dx.doi.org/10.3747/pdi.2012.00109.

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BackgroundOne of the most common and severe complications affecting peritoneal dialysis (PD) patients is exit-site infection of the peritoneal catheter; it is therefore of vital importance to prevent it. This complication has a negative impact on the success of the technique. In spite of this, there are no clear guidelines concerning how to take care of the exit site. The objective of this study was to assess the efficacy of polyhexanide in preventing exit-site infection over a 12-month period.MethodsWe designed a single-center, prospective, open-labeled, randomized controlled clinical trial w

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Kulikova, A. A., Z. S. Khabadze, Yu A. Generalova, R. f. Mokhamed El-Khala, D. A. Nazarova, and Ya A. Yollybayev. "Application of polyhexanide as a new highly effective antiseptic composition." NEW ARMENIAN MEDICAL JOURNAL, no. 1 (2022): 58–63. http://dx.doi.org/10.56936/18290825-2022.16.1-58.

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Currently, antiseptics are used at all stages of surgical treatment. Currently, the search continues for antiseptics that have effective properties in suppressing pathological microflora and as safe as possible in relation to tissues. One of the promising antiseptic solutions is a solution based on polyhexanide. The aim of this work was to study the available reports on the effectiveness of the polyhexanide solution, its safety, and experience of use. To assess the effectiveness of using a polyhexonide solution as an antiseptic, a search was made for publications in the scientific databases “P

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A, Caniglia. "Treatment of Difficult Lesions with Rigenase® and Polyhexanide: Case Series." Angiology & Vascular Surgery 8, no. 1 (2023): 1–3. http://dx.doi.org/10.24966/avs-7397/100104.

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The present study aims to evaluate the efficacy and tolerability of Rigenase® and polyhexanide in the treatment of difficult lesions at risk of infection. Rigenase® is a specific wheat extract with antioxidant properties that promote tissue regeneration. Polyhexanide is a latest generation antiseptic that does not give antimicrobial resistance either in vitro or in vivo.

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Lorenz, M. B., P. Gkogkolou, R. Köck, and T. Goerge. "MRSA decolonisation using polyhexanide 0.1 % with application where necessary of systemic antibiotics." Phlebologie 46, no. 02 (2017): 98–104. http://dx.doi.org/10.12687/phleb2350-2-2017.

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SummaryBackground: Increasing infections and drug resistances lead to new treatment concepts in terms of MRSA decolonisation. An antibiotic-free decolonisation treatment with topical antiseptics is of great clinical interest. We investigated the effectiveness of MRSA decolonisation therapy using the topical antiseptic agent polyhexanide 0.1 %. If needed, a systemic antibiotic was added in case of hospitalisation, abscess formation, chronic wounds and others.Patients and methods: 63 patients were introduced to our outpatient clinic within a period of record of 15 months. 42 (66.7 %) of them wer

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Bagnyuk, N. A., O. A. Nazarchuk, Y. M. Babina, R. M. Chornopyshchuk, and A. V. Kulyk. "Antimicrobial activity of antiseptics in the prevention of postoperative infectious complications." Biomedical and Biosocial Anthropology, no. 40 (November 27, 2021): 33–36. http://dx.doi.org/10.31393/bba40-2020-05.

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Recently, among hospital strains of microorganisms, an increase in the number of antiseptic-resistant strains of opportunistic pathogens has been registered, which significantly affects the effectiveness of these drugs. It is important to study their antimicrobial efficacy to justify rational use. The aim is to conduct a comparative study of the antimicrobial efficacy of antiseptics of decamethoxine, chlorhexidine, polyhexanide. During study we examined the antimicrobial activity against 186 clinical strains of microorganisms (Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aerugin

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Maglione, Barbara. "In vitro Evaluationof the Antimi- crobial Activity of a Topical Skin Preparation Containing 0.1% Polyhexanide vs a Topical Skin Prepa-ration Containing 1% Silver Sulfadiazine." Clinical Dermatology and Therapy 6, no. 2 (2021): 1–7. http://dx.doi.org/10.24966/cdt-8771/100055.

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Aim: The effective in vitro antibacterial activity on Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aeruginosa), Klebsiella pneumoniae (K.pneumoniae),Escherichia coli (E.Coli) and the combination of S.aureus and K. pneumonia of a topical cream based on 0.1% polyhexanidewas compared to a topical cream based on 1% silver sulfadiazine.A topical cream containing 0,1% gentamicin was used as a positive control and a white blank topical cream was used as negative control. Materials and Methods: The in vitro antibacterial activities were determined by agar well-diffusion assay. Two-way A

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Gumenyuk, S. E., O. A. Kachanova, D. I. Ushmarov, et al. "Comprehensive Assessment of the Efficacy of Chitosan-Based Wound Dressings in Combination With Various Antiseptics." Innovative Medicine of Kuban, no. 2 (April 29, 2024): 78–86. http://dx.doi.org/10.35401/2541-9897-2024-9-2-78-86.

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Background: A pressing issue in modern purulent surgery is the growing number of microbial strains resistant to antibiotics. One of the strategies to address this issue is to develop novel wound dressings (WD) with incorporation of antiseptics that can prevent or reduce infection without conventional antibiotics.Objective: To compare the efficacy of chitosan-based WD with immobilized antiseptics and their combinations in in vitro and in vivo experiments.Materials and methods: We conducted a multistage randomized controlled in vitro and in vivo study investigating samples of chitosan-based WD w

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Raditya, I. Nyoman Yuda, K. G. Mulyadi Ridia, I. G. N. Wien Aryana, Ni Nengah Dwi Fatmawati, and I. Ketut Suyasa. "Differences in Decreasing Bacteria Colonization Wound Irrigation using 0.9% Nacl Compared with Wound Irrigation using Active Ingredients Polyhexanide 0.1% and 0.1% Betaine in Open Fractures of Long Bone." Open Access Macedonian Journal of Medical Sciences 11, B (2023): 514–18. http://dx.doi.org/10.3889/oamjms.2023.11599.

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BACKGROUND: An open fracture is an emergency case that must be treated quickly to prevent infection. The use of an irrigation solution containing 0.1% of the antimicrobial polyhexanide and 0.1% of the surfactant betaine has been associated with more satisfactory wound healing. AIM: This study was comparing irrigation with polyhexanide 0.1% and betaine 0.1% (P + B) in reducing bacterial colonization of open fractures compared to using 0.9% natrium chloride (NaCl) solution. METHODS: This study uses a pre- and post-control group design. Sampling was carried out in the operation room of the emerge

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Kilo, Juliane, Julia Dumfarth, Daniel Höfer, and Michael Grimm. "Successful Treatment of Driveline Infection with Vacuum-Assisted Closure Therapy and Instillation Therapy." Thoracic and Cardiovascular Surgeon Reports 09, no. 01 (2020): e29-e32. http://dx.doi.org/10.1055/s-0040-1713731.

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Abstract Background Driveline infection is a serious complication in left ventricular assist device (LVAD) patients. We report the case of a patient who was successfully treated by combining instillation and vacuum-assisted closure (VAC) therapy. Case Description A 65-year-old LVAD patient presented with recurrent driveline infection. Local therapy with VAC therapy in combination with instillation of polyhexanide was performed for 2 weeks. The patient remains free from infection for twelve months by now. Conclusion This case is the first to present the combination of polyhexanide instillation

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Kautz, O., H. Schumann, F. Degerbeck, L. Venemalm, and T. Jakob. "Severe anaphylaxis to the antiseptic polyhexanide." Allergy 65, no. 8 (2010): 1068–70. http://dx.doi.org/10.1111/j.1398-9995.2009.02299.x.

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Falciglia, Maria Domenica, Roberta Palladino, Barbara Maglione, and Giulia Schiavo. "In Vitro Antimicrobial Activity Evaluation of a Novel Fitostimoline® Plus Spray Formulation." International Journal of Microbiology 2021 (September 2, 2021): 1–7. http://dx.doi.org/10.1155/2021/1114853.

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Wound contaminants are the main cause of healing delay and infection in both chronic and acute wounds; for this reason, the microbial infection management in wound healing is one of the most important components for an effective standard of care. The wound contaminants are most likely to originate from the environment and from the surrounding skin lesion, and to date, the most frequent bacteria isolated are Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In order to counteract and control these contaminants, the standard care includes topical antiseptic agents. The mo

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Nazarchuk, O. A., P. S. Rusak, R. M. Chornopyshchuk, et al. "Properties of the antimicrobial activity of polyhexanide drugs against the dominant pathogens of wound infection in Ukraine: modern realities." Paediatric Surgery. Ukraine, no. 3(84) (September 28, 2024): 12–21. https://doi.org/10.15574/ps.2024.3(84).1221.

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The treatment of acute and chronic wounds with critical colonization by wound pathogens remains a serious problem, which is becoming more and more threatening every year due to the global problem of antibiotic resistance. Aim - to study the antimicrobial activity of modern antiseptic Polyhexanide and antimicrobial biomaterials based on it against most common pathogens of wound infections. Materials and methods. Antimicrobial activity of polyhexanide solution were studied against MLS -resistant clinical isolates of S. aureus, MDR- strains of E. coli, clinical XDR-isolates of K. pneumoniae, P. a

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De Decker, Ignace, Dries Janssens, Kimberly De Mey, et al. "Assessing antibacterial efficacy of a polyhexanide hydrogel versus alginate-based wound dressing in burns." Journal of Wound Care 33, no. 5 (2024): 335–47. http://dx.doi.org/10.12968/jowc.2024.33.5.335.

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Objective: Burn injuries pose a heightened risk of infection, which is primarily responsible for increased morbidity and mortality. Factors such as extensive skin damage and compromised immunity exacerbate this vulnerability. Pseudomonas aeruginosa and Staphylococcus aureus are frequently identified in burns, with Gram-negative Pseudomonas aeruginosa often resistant to antibacterial agents. While Flaminal, an alginate-based wound dressing (Flen Health, Belgium), aids wound healing, its antibacterial effects are limited compared with 1% silver sulfadiazine (1% SSD). In contrast, Prontosan Wound

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Nydrioti, Eleni, Benilde Saramago, and Ana Paula Serro. "Polyhexanide and chlorhexidine loaded chitosan wound dressings." Annals of Medicine 53, sup1 (2021): S119. http://dx.doi.org/10.1080/07853890.2021.1896112.

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Szkołuda, Patrycja, and Tomasz M. Karpiński. "Polyhexanide (PHMB) – properties and applications in medicine." European Journal of Biological Research 10, no. 3 (2020): 225–31. https://doi.org/10.5281/zenodo.3956819.

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Polyhexamethylene biguanide (PHMB) is one of the many antiseptics available in the medicine. It stands out from the others with its numerous advantages. It has a low toxicity factor, chemical stability, and bactericidal effect on most microorganisms. PHMB is used in many areas of medicine, veterinary medicine, gastronomy, and industry. The application of polyhexanide in the treatment of chronic wounds allows for fast regeneration and reduced time of wound treatment and hospitalization. According to the Recommendations of the Polish Wound Treatment Society, PHMB is recommended in treatment of c

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Khabadze, Zurab, Yulia Generalova, Alena Kulikova, et al. "Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment." Dentistry Journal 11, no. 3 (2023): 65. http://dx.doi.org/10.3390/dj11030065.

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Background:chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment. Methods: the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases. Results: the number of literary sources that were identified during the li

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Strobel, Rahel M., Marja Leonhardt, Frank Förster, et al. "The impact of surgical site infection—a cost analysis." Langenbeck's Archives of Surgery 407, no. 2 (2021): 819–28. http://dx.doi.org/10.1007/s00423-021-02346-y.

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Abstract Purpose Surgical site infection (SSI) occurs in up to 25% of patients after elective laparotomy. We aimed to determine the effect of SSI on healthcare costs and patients’ quality of life. Methods In this post hoc analysis based on the RECIPE trial, we studied a 30-day postoperative outcome of SSI in a single-center, prospective randomized controlled trial comparing subcutaneous wound irrigation with 0.04% polyhexanide to 0.9% saline after elective laparotomy. Total medical costs were analyzed accurately per patient with the tool of our corporate controlling team which is based on diag

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Khabadze, Z. S., Yu A. Generalova, Yu A. Taptun, L. A. Kozhevnikova, F. Ya Gadzhiev, and M. Yu Dashtieva. "The effect of the irrigation solutions on dentin organic components: Pilot study." Endodontics Today 22, no. 1 (2024): 19–24. http://dx.doi.org/10.36377/et-0011.

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INTRODUCTION. Tooth decay and its complications are prevalent dental issues among adults. Endodontic treatment is the standard of care for complicated caries, specifically pulpitis and periodontitis. Endodontic irrigants, which are placed in the root canal lumen for a specific duration, can affect the intracanal dentin structure (organic and inorganic substances) in various ways. The use of polyhexanide-based antiseptic products in endodontics is a promising idea to overcome microbial resistance and minimize microbial-related endodontic treatment failures.AIM. The aim of this study is to inves

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Dammaschke, Till, Nina Jung, Inga Harks, and Edgar Schafer. "The effect of different root canal medicaments on the elimination of Enterococcus faecalis ex vivo." European Journal of Dentistry 07, no. 04 (2013): 442–48. http://dx.doi.org/10.4103/1305-7456.120683.

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ABSTRACT Objective: The aim of this study was to evaluate the antimicrobial effect of chlorhexidine gel (CHX-G) 2%, chlorhexidine powder (CHX-P) 1%, povidone-iodine (PVP-I), polyhexanide and camphorated-and-mentholated chlorophenol (ChKM) ex vivo. Materials and Methods: For every medicament group 10 root segments (15 mm long) of extracted human teeth were prepared to ISO-size 45 and sterilized (n = 50). The root segments were then inoculated with Enterococcus faecalis and aerobically incubated at 37°C. After 1 week, ten root canals were filled with one of the medicaments, respectively and aero

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Khabadze, Z. S., Yu A. Generalova, and A. A. Kulikova. "The investigation of endodontic irrigants and polyhexanide-based solution action on smear layer." Endodontics Today 22, no. 3 (2024): 199–205. http://dx.doi.org/10.36377/et-0034.

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AIM. The effect of irrigants on the smear layer on the intracanalicular dentin surface is one of the important issues in endodontics. The objective of this article is to determine the effect of different concentrations of polyhexanide-based solutions and standard irrigants on the smear layer using scanning electron microscopy (SEM).MATERIALS AND METHODS. The present study was conducted on 42 extracted teeth (third molars, first and second premolars) with formed apices that had been extracted for orthodontic indications. The teeth were decoronated and samples were prepared. In order to create a

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Fabry, Werner Hugo Karl, Hans-Jürgen Kock, and Winfried Vahlensieck. "Activity of the Antiseptic Polyhexanide Against Gram-Negative Bacteria." Microbial Drug Resistance 20, no. 2 (2014): 138–43. http://dx.doi.org/10.1089/mdr.2013.0113.

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Krasowski, Grzegorz, Paweł Migdał, Marta Woroszyło, et al. "The Assessment of Activity of Antiseptic Agents against Biofilm of Staphylococcus aureus Measured with the Use of Processed Microscopic Images." International Journal of Molecular Sciences 23, no. 21 (2022): 13524. http://dx.doi.org/10.3390/ijms232113524.

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Staphylococcal biofilms are major causative factors of non-healing wound infections. Their treatment algorithms recommend the use of locally applied antiseptic agents to counteract the spread of infection. The efficacy of antiseptics against biofilm is assessed in vitro by a set of standard quantitative and semi-quantitative methods. The development of software for image processing additionally allowed for the obtainment of quantitative data from microscopic images of biofilm dyed with propidium iodine and SYTO-9 reagents, differentiating dead cells from live ones. In this work, the method of

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Wild, Thomas, Maria Bruckner, Martina Payrich, Christoph Schwarz, Thomas Eberlein, and Anneke Andriessen. "Eradication of Methicillin-Resistant Staphylococcus aureus in Pressure Ulcers Comparing a Polyhexanide-Containing Cellulose Dressing with Polyhexanide Swabs in a Prospective Randomized Study." Advances in Skin & Wound Care 25, no. 1 (2012): 17–22. http://dx.doi.org/10.1097/01.asw.0000410686.14363.ea.

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Quiñones-Vico, María I., Ana Fernández-González, Elena Pérez-Castejón, Trinidad Montero-Vílchez, and Salvador Arias-Santiago. "Cytotoxicity and Epidermal Barrier Function Evaluation of Common Antiseptics for Clinical Use in an Artificial Autologous Skin Model." Journal of Clinical Medicine 10, no. 4 (2021): 642. http://dx.doi.org/10.3390/jcm10040642.

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Bioengineered artificial skin substitutes (BASS) are the main treatment used in addition to autografts when skin injuries involve a large body surface area. Antiseptic/antibiotic treatment is necessary to prevent infections in the BASS implant area. This study aims to evaluate the effect of antiseptics and antibiotics on cell viability, structural integrity, and epidermal barrier function in BASS based on hyaluronic acid during a 28 day follow-up period. Keratinocytes (KTs) and dermal fibroblasts (DFs) were isolated from skin samples and used to establish BASS. The following antibiotic/antisep

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Schug, Angela R., Anissa D. Scholtzek, John Turnidge, Marita Meurer, Stefan Schwarz, and Andrea T. Feßler. "Development of Quality Control Ranges for Biocide Susceptibility Testing." Pathogens 11, no. 2 (2022): 223. http://dx.doi.org/10.3390/pathogens11020223.

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Every laboratory test needs validation by quality controls. For biocide susceptibility testing (BST), neither quality control (QC) strains nor QC ranges applicable to these strains are currently available. As QC strains, four well-defined laboratory reference strains (Staphylococcus aureus ATCC® 6538, Enterococcus hirae ATCC® 10541, Escherichia coli ATCC® 10536 and Pseudomonas aeruginosa ATCC® 15442), which have been used previously for biocide efficacy testing, were selected. In an interlaboratory trial with eleven participating laboratories, BST QC ranges should be developed for the aforemen

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Uygur, Fatih, Mustafa Özyurt, Rahmi Evinç, Tugrul Hosbul, Bahattin Çeliköz, and Tuncer Haznedaroglu. "Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats." Open Medicine 3, no. 4 (2008): 417–21. http://dx.doi.org/10.2478/s11536-008-0042-x.

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AbstractPseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on experimental burn wounds in in rats contaiminated with P. aeruginosa.

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Zurab, Z. S., Yu A. Generalova, A. A. Kulikova, et al. "Analysis of the chemical interaction of polyhexanide with endodontic irrigants." Endodontics Today 22, no. 4 (2024): 319–34. https://doi.org/10.36377/et-0051.

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INTRODUCTION. Chronic apical periodontitis (CAP) poses significant challenges in endodontics due to microbial resistance and inadequate disinfection protocols. Polyhexanide (PHMB) is a promising irrigant due to its antimicrobial properties. However, its interactions with other commonly used endodontic irrigants require further investigation to establish effective and safe clinical protocols. AIM. To evaluate the chemical interactions of PHMB with sodium hypochlorite (NaOCl), hydrogen peroxide (H2O2), EDTA, and chlorhexidine and identify optimal irrigation protocols.MATERIALS AND METHODS. The s

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Röhner, Eric, Paula Hoff, Tobias Winkler, et al. "Polyhexanide and hydrogen peroxide inhibit proteoglycan synthesis of human chondrocytes." Journal of Histotechnology 34, no. 1 (2011): 35–39. http://dx.doi.org/10.1179/014788811x12949268296121.

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Firdessa, Rebuma, Liam Good, Maria Cecilia Amstalden, et al. "Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB)." PLOS Neglected Tropical Diseases 9, no. 10 (2015): e0004041. http://dx.doi.org/10.1371/journal.pntd.0004041.

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Ristau, Tina, Bernd Kirchhof, and Sascha Fauser. "Antisepsis with polyhexanide is effective against endophthalmitis after intravitreal injections." Acta Ophthalmologica 92, no. 6 (2014): e494-e496. http://dx.doi.org/10.1111/aos.12347.

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Guiomar, António Jorge, and Ana M. Urbano. "Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review." Membranes 12, no. 12 (2022): 1281. http://dx.doi.org/10.3390/membranes12121281.

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The prevalence of chronic, non-healing skin wounds in the general population, most notably diabetic foot ulcers, venous leg ulcers and pressure ulcers, is approximately 2% and is expected to increase, driven mostly by the aging population and the steady rise in obesity and diabetes. Non-healing wounds often become infected, increasing the risk of life-threatening complications, which poses a significant socioeconomic burden. Aiming at the improved management of infected wounds, a variety of wound dressings that incorporate antimicrobials (AMDs), namely polyhexanide (poly(hexamethylene biguanid

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Yao, Chenghao, Jingyang Lin, and Shuai Zhang. "Polyhexanide derivatives-reinforced silver-polytetrafluoroethylene coatings for enhanced antibacterial properties." Next Materials 8 (July 2025): 100541. https://doi.org/10.1016/j.nxmate.2025.100541.

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Dudek, Bartłomiej, Malwina Brożyna, Michał Karoluk, et al. "In Vitro and In Vivo Translational Insights into the Intraoperative Use of Antiseptics and Lavage Solutions Against Microorganisms Causing Orthopedic Infections." International Journal of Molecular Sciences 25, no. 23 (2024): 12720. http://dx.doi.org/10.3390/ijms252312720.

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The growing antibiotic resistance of microorganisms causing postoperative infections following orthopedic surgeries underscores the urgent need for localized antiseptic and lavage delivery systems to enhance infection control. This study evaluates the in vitro effectiveness of antiseptic and lavage solutions—including polyhexanide, povidone–iodine, low-concentrated hypochlorite, Ringer’s solution, and saline—against Staphylococcus epidermidis, Staphylococcus aureus MRSA, Cutibacterium acnes, Corynebacterium amycolatum, Pseudomonas aeruginosa, and Candida albicans. Using microplate models (Mini

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Dydak, Karolina, Adam Junka, Agata Dydak, et al. "In Vitro Efficacy of Bacterial Cellulose Dressings Chemisorbed with Antiseptics against Biofilm Formed by Pathogens Isolated from Chronic Wounds." International Journal of Molecular Sciences 22, no. 8 (2021): 3996. http://dx.doi.org/10.3390/ijms22083996.

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Local administration of antiseptics is required to prevent and fight against biofilm-based infections of chronic wounds. One of the methods used for delivering antiseptics to infected wounds is the application of dressings chemisorbed with antimicrobials. Dressings made of bacterial cellulose (BC) display several features, making them suitable for such a purpose. This work aimed to compare the activity of commonly used antiseptic molecules: octenidine, polyhexanide, povidone-iodine, chlorhexidine, ethacridine lactate, and hypochlorous solutions and to evaluate their usefulness as active substa

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Jones, Lyndon, Deborah Jones, and Mark Houlford. "Clinical comparison of three polyhexanide-preserved multi-purpose contact lens solutions." Contact Lens and Anterior Eye 20, no. 1 (1997): 23–30. http://dx.doi.org/10.1016/s1367-0484(97)80032-x.

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Zanchin, Túlio Neutzling, Cássio Battisti Serafini, Francine Silva Brandão, and José Augusto da Costa Nery. "Polyhexanide 0.2% in treatment of trophic foot ulcers in leprosy - preliminary study." Anais Brasileiros de Dermatologia 93, no. 1 (2018): 145–47. http://dx.doi.org/10.1590/abd1806-4841.20186655.

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Schunter, Jo Ana, Benedikt Stöcker, and Randolf Brehler. "A Case of Severe Anaphylaxis to Polyhexanide: Cross-Reactivity between Biguanide Antiseptics." International Archives of Allergy and Immunology 173, no. 4 (2017): 233–36. http://dx.doi.org/10.1159/000478700.

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Rusiecka-Ziółkowska, Jolanta, Aneta Hill-Bator, Elżbieta Piątkowska, Małgorzata Mimier-Janczak, Kaja Bator, and Marta Misiuk-Hojło. "The eye wipes with polyhexanide (HexaClean) in preoperative prophylaxis of cataract surgery." Ophthalmology Journal 8 (February 20, 2023): 38–45. http://dx.doi.org/10.5603/oj.2023.0009.

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Andersen, Litti, Marianne Bertelsen, Vicki Buitenhuis, et al. "Maintenance of indwelling urinary catheters with a novel polyhexanide-based solution: user experience." British Journal of Nursing 29, no. 18 (2020): S18—S28. http://dx.doi.org/10.12968/bjon.2020.29.18.s18.

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Background: Catheter-associated urinary tract infection (CAUTI) can significantly affect patients' quality of life and increase healthcare costs. Aims: This study aimed to capture patients' and nurses' experience of catheter maintenance using a polyhexanide-based solution (PS) in everyday practice. Methods: Retrospective analysis of data was collected for a product evaluation. PS was used twice a week for five weeks. Findings: The study included 42 patients, 30 (71%) men and 12 women (29%). After five weeks of rinsing catheters with PS, nine patients reported no or decreased frequency of CAUTI

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Röhner, Eric, Carsten Perka, Kristin Andreas, Andrej M. Kielbassa, Georg Matziolis, and Nicole Pischon. "Comparable Effects of Polyhexanide and Chlorhexidine on Cell Viability of Primary Human Chondrocytes." CYTOLOGIA 76, no. 4 (2011): 475–82. http://dx.doi.org/10.1508/cytologia.76.475.

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Kock, Hans-Jürgen, Dirk Ernst, Frank Jethon, and Werner Fabry. "In-vitro analysis of the effect of gentamicin and polyhexanide on bone tissue." International Orthopaedics 37, no. 4 (2013): 761–67. http://dx.doi.org/10.1007/s00264-013-1786-8.

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Goertz, O., C. Abels, U. Knie, et al. "Clinical Safety and Efficacy of a Novel Thermoreversible Polyhexanide-Preserved Wound Covering Gel." European Surgical Research 44, no. 2 (2010): 96–101. http://dx.doi.org/10.1159/000276303.

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Fabry, W., C. Reimer, T. Azem, C. Aepinus, H. J. Kock, and W. Vahlensieck. "Activity of the antiseptic polyhexanide against meticillin-susceptible and meticillin-resistant Staphylococcus aureus." Journal of Global Antimicrobial Resistance 1, no. 4 (2013): 195–99. http://dx.doi.org/10.1016/j.jgar.2013.05.007.

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Vaz, Luís M., Rita Branco, Paula V. Morais, and António Jorge Guiomar. "Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings." Membranes 13, no. 11 (2023): 877. http://dx.doi.org/10.3390/membranes13110877.

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Wound infection is a common complication of chronic wounds. It can impair healing, which may not occur without external help. Antimicrobial dressings (AMDs) are a type of external help to infected chronic wounds. In this study, highly porous membranes made of only chitosan and containing the antiseptic polyhexanide (poly(hexamethylene biguanide); PHMB) were prepared by cryogelation, aiming to be used in AMDs. These membranes exhibited a water swelling capacity of 748%, a water drop penetration time of 11 s in a dry membrane and a water vapor transmission rate of 34,400 g H2O/m2/24 h when in co

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Fabry, W., and H. J. Kock. "In-vitro activity of polyhexanide alone and in combination with antibiotics against Staphylococcus aureus." Journal of Hospital Infection 86, no. 1 (2014): 68–72. http://dx.doi.org/10.1016/j.jhin.2013.10.002.

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Neeff, Hannes P., Mueller S. Anna, Philipp A. Holzner, Guido Wolff-Vorbeck, Ulrich T. Hopt, and Frank Makowiec. "Mo1765 Effect of Polyhexanide on the Incidence of Surgical Site Infections After Colorectal Surgery." Gastroenterology 150, no. 4 (2016): S1244. http://dx.doi.org/10.1016/s0016-5085(16)34202-0.

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