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Journal articles on the topic 'Polyion complex micelles (PIC)'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Chen, Fan, and Martina H. Stenzel. "Polyion Complex Micelles for Protein Delivery." Australian Journal of Chemistry 71, no. 10 (2018): 768. http://dx.doi.org/10.1071/ch18219.

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Proteins are ubiquitous in life and next to water, they are the most abundant compounds found in human bodies. Proteins have very specific roles in the body and depending on their function, they are for example classified as enzymes, antibodies or transport proteins. Recently, therapeutic proteins have made an impact in the drug market. However, some proteins can be subject to quick hydrolytic degradation or denaturation depending on the environment and therefore require a protective layer. A range of strategies are available to encapsulate and deliver proteins, but techniques based on polyelectrolyte complex formation stand out owing to their ease of formulation. Depending on their isoelectric point, proteins are charged and can condense with oppositely charged polymers. Using block copolymers with a neutral block and a charged block results in the formation of polyion complex (PIC) micelles when mixed with the oppositely charged protein. The neutral block stabilises the charged protein–polymer core, leading to nanoparticles. The types of micelles are also known under the names interpolyelectrolyte complex, complex coacervate core micelles, and block ionomer complexes. In this article, we discuss the formation of PIC micelles and their stability. Strategies to enhance the stability such as supercharging the protein or crosslinking the PIC micelles are discussed.

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2

Chen, Fan, Radhika Raveendran, Cheng Cao, Robert Chapman, and Martina H. Stenzel. "Correlation between polymer architecture and polyion complex micelle stability with proteins in spheroid cancer models as seen by light-sheet microscopy." Polymer Chemistry 10, no. 10 (2019): 1221–30. http://dx.doi.org/10.1039/c8py01565a.

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3

Miyazaki, Takuya, Satoshi Uchida, Yuji Miyahara, Akira Matsumoto, and Horacio Cabral. "Development of Flexible Polycation-Based mRNA Delivery Systems for In Vivo Applications." Materials Proceedings 4, no. 1 (November 12, 2020): 5. http://dx.doi.org/10.3390/iocn2020-07857.

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mRNA is a promising therapeutic nucleic acid, although effective delivery systems are required for its broad application. Polyion complex (PIC) micelles loading mRNA via polyion complexation with block catiomers are emerging as promising carriers for mRNA delivery, but the PIC stability has been limited so far. Controlling the binding of polycations to mRNA could affect the micelle stability. Nevertheless, the impact of binding affinity between polycations and mRNA on the function of mRNA-loaded PIC micelles (mRNA/m) remains unknown. Herein, we review our recent orthogonal approaches controlling the stiffness and the valency of polycations to improve the performance of mRNA/m toward enhancing stability and delivery efficiency. Thus, block catiomers with contrasting flexibility were developed to prepare mRNA/m. The flexible catiomer stabilized mRNA/m against enzymatic attack and polyanion exchange compared to the rigid catiomer, promoting protein translation in vitro and in vivo, and prolonged mRNA bioavailability in blood after systemic injection. Based on these observations, we also developed flexible catiomers with different valencies. The guanidinated catiomer stabilized mRNA/m compared to the aminated catiomers, facilitating intracellular delivery and eventual gene expression. Our findings indicate the importance of controlling the polymer binding to mRNA for developing flexible polycation-based systems directed to in vivo applications.

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Lopez-Blanco, Roi, Marcos Fernandez-Villamarin, Sorel Jatunov, Ramon Novoa-Carballal, and Eduardo Fernandez-Megia. "Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles." Polymer Chemistry 10, no. 34 (2019): 4709–17. http://dx.doi.org/10.1039/c9py00727j.

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Dendritic-polysaccharide PIC micelles represent promising delivery systems where dendritic rigidity and polysaccharide stiffness synchronize to determine the stability of the micelles, their kinetics of intracellular drug release, and cytotoxicity.

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5

Yang, Wenqian, Takuya Miyazaki, Taehun Hong, and Horacio Cabral. "Effect of PEG-Polycation Chain Flexibility on siRNA Loaded Polyion Complex Micelles Assembly and Performance." Materials Proceedings 4, no. 1 (November 12, 2020): 88. http://dx.doi.org/10.3390/iocn2020-07985.

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RNA interference (RNAi) has emerged as a promising therapeutic approach for the treatment of a wide range of disorders. Small interfering RNAs (siRNAs), i.e., non-coding double-stranded RNA molecules, have been mainly used for RNAi. Because siRNA is susceptible to enzymatic degradation and is rapidly cleared from the bloodstream, the success of RNAi is strongly related to the design of efficient delivery technologies. Among auspicious carriers for siRNA, polymeric micelles self-assembled by polyion complexation between block ionomers and siRNA have attracted much attention due to their well-defined size, efficient complexation and potential for delivery in vivo. In this regard, we have recently demonstrated that the polycation flexibility influences the complexation with single stranded RNA molecules, affecting the delivery capability of the resulting micelles. On the other hand, the effects of the catiomer flexibility on micelles loading double stranded siRNA remains unknown. Thus, herein, we studied the effects of the polycation backbone flexibility on siRNA-loaded polyion complex (PIC) micelles by using complementary block copolymers, i.e., the relatively flexible poly(ethylene glycol)-poly(glycidylbutylamine) (PEG-PGBA) and the more rigid PEG-poly(L-lysine) (PEG-PLL). By mixing these polymers with siRNA at different N/P ratios, we found that PEG-PGBA effectively promoted self-assembly of PIC micelles at lower N/P ratios and lower siRNA concentrations than PEG-PLL. Computational studies of siRNA binding with polycations and PEG-polycations further supported the favorable binding process of flexible polycations with siRNA. The micelles based on PEG-PGBA were stable in physiological conditions and promoted effective intracellular delivery of siRNA for efficient gene knockdown. Our results indicate the importance of polycation flexibility for the assembly of PIC micelles with siRNA, and its potential for developing innovative carrier systems.

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6

Nakamura, Noriko, Yuki Mochida, Kazuko Toh, Shigeto Fukushima, Horacio Cabral, and Yasutaka Anraku. "Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application." Polymers 13, no. 1 (December 22, 2020): 5. http://dx.doi.org/10.3390/polym13010005.

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Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.

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7

Molina, Emilie, Mélody Mathonnat, Jason Richard, Patrick Lacroix-Desmazes, Martin In, Philippe Dieudonné, Thomas Cacciaguerra, Corine Gérardin, and Nathalie Marcotte. "pH-mediated control over the mesostructure of ordered mesoporous materials templated by polyion complex micelles." Beilstein Journal of Nanotechnology 10 (January 11, 2019): 144–56. http://dx.doi.org/10.3762/bjnano.10.14.

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Ordered mesoporous silica materials were prepared under different pH conditions by using a silicon alkoxide as a silica source and polyion complex (PIC) micelles as the structure-directing agents. PIC micelles were formed by complexation between a weak polyacid-containing double-hydrophilic block copolymer, poly(ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA), and a weak polybase, oligochitosan-type polyamine. As both the micellization process and the rate of silica condensation are highly dependent on pH, the properties of silica mesostructures can be modulated by changing the pH of the reaction medium. Varying the materials synthesis pH from 4.5 to 7.9 led to 2D-hexagonal, wormlike or lamellar mesostructures, with a varying degree of order. The chemical composition of the as-synthesized hybrid organic/inorganic materials was also found to vary with pH. The structure variations were discussed based on the extent of electrostatic complexing bonds between acrylate and amino functions and on the silica condensation rate as a function of pH.

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8

Yuan, Xiaofei, Yuichi Yamasaki, Atsushi Harada, and Kazunori Kataoka. "Characterization of stable lysozyme-entrapped polyion complex (PIC) micelles with crosslinked core by glutaraldehyde." Polymer 46, no. 18 (August 2005): 7749–58. http://dx.doi.org/10.1016/j.polymer.2005.02.121.

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9

Kim, Dongwook, Hideki Matsuoka, and Yoshiyuki Saruwatari. "Formation of Sulfobetaine-Containing Entirely Ionic PIC (Polyion Complex) Micelles and Their Temperature Responsivity." Langmuir 36, no. 34 (August 2, 2020): 10130–37. http://dx.doi.org/10.1021/acs.langmuir.0c01577.

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10

Yusa, Shin-ichi. "Polyion Complex (PIC) Flower-shaped Nano-micelles formed from Anionic Triblock and Cationic Diblock Copolymers." Nanotechnology: Nanomedicine&Nanobiotechnology 1, no. 1 (December 17, 2014): 1–7. http://dx.doi.org/10.24966/ntmb-2044/100001.

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11

Jang, Woo Dong, Nobuhiro Nishiyama, and Kazunori Kataoka. "Preparation of Naphthalocyanine Dendrimer Loaded Polyion Complex Micelle for Photodynamic Therapy." Key Engineering Materials 342-343 (July 2007): 465–68. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.465.

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A naphthalocyanine dendrimer (DNPcZn) was synthesized as a potential candidate of photosensitizer for photodynamic therapy. DNPcZn exhibited strong Q band absorption around 780 nm, a useful wavelength for high tissue penetration. A polyion complex (PIC) micelle (DNPcZn/m) system was formed via an electrostatic interaction of anionic DNPcZn and poly(ethylene glycol)-poly(L-lysine) block copolymers (PEG-b-PLL).

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12

Birault, Albane, Emilie Molina, Carole Carcel, John Bartlett, Nathalie Marcotte, Guillaume Toquer, Patrick Lacroix-Desmazes, Corine Gerardin, and Michel Wong Chi Man. "Synthesis of lamellar mesostructured phenylene-bridged periodic mesoporous organosilicas (PMO) templated by polyion complex (PIC) micelles." Journal of Sol-Gel Science and Technology 89, no. 1 (May 8, 2018): 189–95. http://dx.doi.org/10.1007/s10971-018-4667-1.

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13

Ohno, Sayaka, Kazuhiko Ishihara, and Shin-ichi Yusa. "Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water." Langmuir 32, no. 16 (April 12, 2016): 3945–53. http://dx.doi.org/10.1021/acs.langmuir.6b00637.

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14

Kim, Dongwook, Hideki Matsuoka, Shin-ichi Yusa, and Yoshiyuki Saruwatari. "Collapse Behavior of Polyion Complex (PIC) Micelles upon Salt Addition and Reforming Behavior by Dialysis and Its Temperature Responsivity." Langmuir 36, no. 51 (December 16, 2020): 15485–92. http://dx.doi.org/10.1021/acs.langmuir.0c02456.

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15

Nakahata, Rina, and Shin-ichi Yusa. "Preparation of Water-soluble Polyion Complex (PIC) Micelles Covered with Amphoteric Random Copolymer Shells with Pendant Sulfonate and Quaternary Amino Groups." Polymers 10, no. 2 (February 19, 2018): 205. http://dx.doi.org/10.3390/polym10020205.

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16

Oishi, Motoi, Tetsuya Hayama, Yoshitsugu Akiyama, Seiji Takae, Atsushi Harada, Yuichi Yamasaki, Fumi Nagatsugi, Shigeki Sasaki, Yukio Nagasaki, and Kazunori Kataoka. "Supramolecular Assemblies for the Cytoplasmic Delivery of Antisense Oligodeoxynucleotide: Polyion Complex (PIC) Micelles Based on Poly(ethylene glycol)-SS-Oligodeoxynucleotide Conjugate." Biomacromolecules 6, no. 5 (September 2005): 2449–54. http://dx.doi.org/10.1021/bm050370l.

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17

Warnant, J., N. Marcotte, J. Reboul, G. Layrac, A. Aqil, C. Jerôme, D. A. Lerner, and C. Gérardin. "Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines." Analytical and Bioanalytical Chemistry 403, no. 5 (March 28, 2012): 1395–404. http://dx.doi.org/10.1007/s00216-012-5947-1.

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18

Insua, Ignacio, Andrew Wilkinson, and Francisco Fernandez-Trillo. "Polyion complex (PIC) particles: Preparation and biomedical applications." European Polymer Journal 81 (August 2016): 198–215. http://dx.doi.org/10.1016/j.eurpolymj.2016.06.003.

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19

Uto, Tomofumi, Takami Akagi, Mitsuru Akashi, and Masanori Baba. "Induction of Potent Adaptive Immunity by the Novel Polyion Complex Nanoparticles." Clinical and Vaccine Immunology 22, no. 5 (March 25, 2015): 578–85. http://dx.doi.org/10.1128/cvi.00080-15.

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ABSTRACTThe development of effective and simple methods of vaccine preparation is desired for the prophylaxis and treatment of a variety of infectious diseases and cancers. We have created novel polyion complex (PIC) nanoparticles (NPs) composed of amphiphilic anionic biodegradable poly(γ-glutamic acid) (γ-PGA) and cationic polymers as a vaccine adjuvant. PIC NPs can be prepared by mixing γ-PGA-graft-l-phenylalanine ethylester (γ-PGA-Phe) polymer with cationic polymer in phosphate-buffered saline. We examined the efficacy of PIC NPs for antigen delivery and immunostimulatory activityin vitroandin vivo. PIC NPs enhanced the uptake of ovalbumin (OVA) by dendritic cells (DCs) and subsequently induced DC maturation. The immunization of mice with OVA-carrying PIC NPs induced potent and antigen-specific cellular and humoral immunity. Since PIC NPs can be created with water-soluble anionic γ-PGA-Phe and a cationic polymer by simple mixing in the absence of any organic solvents, PIC NPs may have potential as a novel candidate for an effective antigen carrier and vaccine adjuvant.

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20

Yessine, Marie-Andrée, Marie-Hélène Dufresne, Christian Meier, Hans-Ulrich Petereit, and Jean-Christophe Leroux. "Proton-Actuated Membrane-Destabilizing Polyion Complex Micelles." Bioconjugate Chemistry 18, no. 3 (May 2007): 1010–14. http://dx.doi.org/10.1021/bc060159m.

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21

Insua, Ignacio, Evangelos Liamas, Zhenyu Zhang, Anna F. A. Peacock, Anne Marie Krachler, and Francisco Fernandez-Trillo. "Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers." Polymer Chemistry 7, no. 15 (2016): 2684–90. http://dx.doi.org/10.1039/c6py00146g.

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Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targetingPseudomonas aeruginosa's elastase.

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22

Nguyen, Vo Thu An, Marie-Claire De Pauw-Gillet, Olivier Sandre, and Mario Gauthier. "Biocompatible Polyion Complex Micelles Synthesized from Arborescent Polymers." Langmuir 32, no. 50 (December 7, 2016): 13482–92. http://dx.doi.org/10.1021/acs.langmuir.6b03683.

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23

Mignani, Serge, Xiangyang Shi, Maria Zablocka, and Jean-Pierre Majoral. "Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles." Biomacromolecules 22, no. 2 (January 11, 2021): 262–74. http://dx.doi.org/10.1021/acs.biomac.0c01645.

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24

Jiang, Yanyan, Hongxu Lu, Fan Chen, Manuela Callari, Mohammad Pourgholami, David L. Morris, and Martina H. Stenzel. "PEGylated Albumin-Based Polyion Complex Micelles for Protein Delivery." Biomacromolecules 17, no. 3 (February 9, 2016): 808–17. http://dx.doi.org/10.1021/acs.biomac.5b01537.

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25

Chen, Jinjin, Jianxun Ding, Ying Zhang, Chunsheng Xiao, Xiuli Zhuang, and Xuesi Chen. "Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery." Polymer Chemistry 6, no. 3 (2015): 397–405. http://dx.doi.org/10.1039/c4py01149j.

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26

Lee, Yan, and Kazunori Kataoka. "Biosignal-sensitive polyion complex micelles for the delivery of biopharmaceuticals." Soft Matter 5, no. 20 (2009): 3810. http://dx.doi.org/10.1039/b909934d.

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27

Usui, Tomohiko, Kenji Sugisaki, Shiro Amano, Woo-Dong Jang, Nobuhiro Nishiyama, and Kazunori Kataoka. "New Drug Delivery for Corneal Neovascularization Using Polyion Complex Micelles." Cornea 24, Supplement 1 (November 2005): S39—S42. http://dx.doi.org/10.1097/01.ico.0000178738.29459.59.

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28

Nakai, Keita, Midori Nishiuchi, Masamichi Inoue, Kazuhiko Ishihara, Yusuke Sanada, Kazuo Sakurai, and Shin-ichi Yusa. "Preparation and Characterization of Polyion Complex Micelles with Phosphobetaine Shells." Langmuir 29, no. 31 (July 24, 2013): 9651–61. http://dx.doi.org/10.1021/la401063b.

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29

Stapert, Hendrik R., Nobuhiro Nishiyama, Dong-Lin Jiang, Takuzo Aida, and Kazunori Kataoka. "Polyion Complex Micelles Encapsulating Light-Harvesting Ionic Dendrimer Zinc Porphyrins." Langmuir 16, no. 21 (October 2000): 8182–88. http://dx.doi.org/10.1021/la000423e.

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30

Chen, Jinjin, Ying Zhang, Jianxun Ding, Chunsheng Xiao, Xiuli Zhuang, and Xuesi Chen. "pH-sensitive polyion complex micelles for tunable intracellular drug delivery." Journal of Controlled Release 213 (September 2015): e55. http://dx.doi.org/10.1016/j.jconrel.2015.05.090.

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31

Luo, Yali, Airong Wang, Jinfang Yuan, and Qingyu Gao. "Preparation, characterization and drug release behavior of polyion complex micelles." International Journal of Pharmaceutics 374, no. 1-2 (June 2009): 139–44. http://dx.doi.org/10.1016/j.ijpharm.2009.03.019.

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32

Zheng, Ruyi, Zheng Wu, Yun Yan, Jide Wang, and Jianbin Huang. "Suppressing singlet oxygen formation from 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin using polyion complex micelles." RSC Advances 5, no. 22 (2015): 17253–56. http://dx.doi.org/10.1039/c4ra16259e.

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33

Nguyen, Vo, Marie-Claire De Pauw-Gillet, Mario Gauthier, and Olivier Sandre. "Magnetic Polyion Complex Micelles for Cell Toxicity Induced by Radiofrequency Magnetic Field Hyperthermia." Nanomaterials 8, no. 12 (December 6, 2018): 1014. http://dx.doi.org/10.3390/nano8121014.

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Magnetic nanoparticles (MNPs) of magnetite (Fe3O4) were prepared using a polystyrene-graft-poly(2-vinylpyridine) copolymer (denoted G0PS-g-P2VP or G1) as template. These MNPs were subjected to self-assembly with a poly(acrylic acid)-block-poly(2-hydroxyethyl acrylate) double-hydrophilic block copolymer (DHBC), PAA-b-PHEA, to form water-dispersible magnetic polyion complex (MPIC) micelles. Large Fe3O4 crystallites were visualized by transmission electron microscopy (TEM) and magnetic suspensions of MPIC micelles exhibited improved colloidal stability in aqueous environments over a wide pH and ionic strength range. Biological cells incubated for 48 h with MPIC micelles at the highest concentration (1250 µg of Fe3O4 per mL) had a cell viability of 91%, as compared with 51% when incubated with bare (unprotected) MNPs. Cell internalization, visualized by confocal laser scanning microscopy (CLSM) and TEM, exhibited strong dependence on the MPIC micelle concentration and incubation time, as also evidenced by fluorescence-activated cell sorting (FACS). The usefulness of MPIC micelles for cellular radiofrequency magnetic field hyperthermia (MFH) was also confirmed, as the MPIC micelles showed a dual dose-dependent effect (concentration and duration of magnetic field exposure) on the viability of L929 mouse fibroblasts and U87 human glioblastoma epithelial cells.

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34

Chen, Yan, Yan Jiao, Yanxiu Ge, Guoxia Liu, Wei Xu, and Lingbing Li. "The Study of Tacrolimus-Loaded Polyion Complex Micelles for Oral Delivery." Journal of Biomedical Nanotechnology 13, no. 9 (December 1, 2017): 1147–57. http://dx.doi.org/10.1166/jbn.2017.2403.

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35

Wang, Chau-Hui, Wei-Ting Wang, and Ging-Ho Hsiue. "Development of polyion complex micelles for encapsulating and delivering amphotericin B." Biomaterials 30, no. 19 (July 2009): 3352–58. http://dx.doi.org/10.1016/j.biomaterials.2009.02.041.

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36

Bayó-Puxan, Núria, Marie-Hélène Dufresne, Arnaud E. Felber, Bastien Castagner, and Jean-Christophe Leroux. "Preparation of polyion complex micelles from poly(ethylene glycol)-block-polyions." Journal of Controlled Release 156, no. 2 (December 2011): 118–27. http://dx.doi.org/10.1016/j.jconrel.2011.07.027.

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37

Yuan, Jinfang, Yali Luo, and Qingyu Gao. "Self-assembled polyion complex micelles for sustained release of hydrophilic drug." Journal of Microencapsulation 28, no. 2 (January 26, 2011): 93–98. http://dx.doi.org/10.3109/02652048.2010.534823.

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38

Insua, Ignacio, Sieta Majok, Anna F. A. Peacock, Anne Marie Krachler, and Francisco Fernandez-Trillo. "Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B." European Polymer Journal 87 (February 2017): 478–86. http://dx.doi.org/10.1016/j.eurpolymj.2016.08.023.

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39

Raisin, Sophie, Marie Morille, Claire Bony, Danièle Noël, Jean-Marie Devoisselle, and Emmanuel Belamie. "Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection." Biomaterials Science 5, no. 9 (2017): 1910–21. http://dx.doi.org/10.1039/c7bm00384f.

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In this study, we demonstrate that PIC micelles readily form at physiological pH in the presence of siRNA and disassemble at a pH close to that of endosomes. Internalization of the micelles in primary MSC results in the down-regulation of Runx2.

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40

Liu, Yun, Cao Li, Hui-Yuan Wang, Xian-Zheng Zhang, and Ren-Xi Zhuo. "Synthesis of Thermo- and pH-Sensitive Polyion Complex Micelles for Fluorescent Imaging." Chemistry - A European Journal 18, no. 8 (January 16, 2012): 2297–304. http://dx.doi.org/10.1002/chem.201102704.

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41

Fernandez-Villamarin, Marcos, Ana Sousa-Herves, Silvia Porto, Noelia Guldris, José Martínez-Costas, Ricardo Riguera, and Eduardo Fernandez-Megia. "A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles." Polym. Chem. 8, no. 16 (2017): 2528–37. http://dx.doi.org/10.1039/c7py00304h.

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42

Jin, Qiao, Tongjiang Cai, and Jian Ji. "Light and pH dual responsive polyion complex micelles for efficient protein delivery." Journal of Controlled Release 213 (September 2015): e90-e91. http://dx.doi.org/10.1016/j.jconrel.2015.05.150.

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43

Boudier, Ariane, Anne Aubert-Pouëssel, Pascale Louis-Plence, Corine Gérardin, Christian Jorgensen, Jean-Marie Devoisselle, and Sylvie Bégu. "The control of dendritic cell maturation by pH-sensitive polyion complex micelles." Biomaterials 30, no. 2 (January 2009): 233–41. http://dx.doi.org/10.1016/j.biomaterials.2008.09.033.

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44

Ohya, Yuichi, Shinya Takeda, Yosuke Shibata, Tatsuro Ouchi, and Atsushi Maruyama. "Preparation of Highly Stable Biodegradable Polymer Micelles by Coating with Polyion Complex." Macromolecular Chemistry and Physics 211, no. 16 (July 2, 2010): 1750–56. http://dx.doi.org/10.1002/macp.201000167.

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45

Zhang, Dandan, Jilu Li, Hongmei Xie, Aoqi Zhu, Yiting Xu, Birong Zeng, Weiang Luo, and Lizong Dai. "Polyion complex micelles formed by azobenzene‐based polymer with multi‐responsive properties." Journal of Applied Polymer Science 138, no. 24 (February 13, 2021): 50580. http://dx.doi.org/10.1002/app.50580.

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46

Liu, Ssu-Ting, Ho-Yi Tuan-Mu, Jin-Jia Hu, and Jeng-Shiung Jan. "Genipin cross-linked PEG-block-poly(l-lysine)/disulfide-based polymer complex micelles as fluorescent probes and pH-/redox-responsive drug vehicles." RSC Advances 5, no. 106 (2015): 87098–107. http://dx.doi.org/10.1039/c5ra18802d.

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47

Lall, Aastha, Arnaud Kamdem Tamo, Ingo Doench, Laurent David, Paula Nunes de Oliveira, Christian Gorzelanny, and Anayancy Osorio-Madrazo. "Nanoparticles and Colloidal Hydrogels of Chitosan–Caseinate Polyelectrolyte Complexes for Drug-Controlled Release Applications." International Journal of Molecular Sciences 21, no. 16 (August 5, 2020): 5602. http://dx.doi.org/10.3390/ijms21165602.

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Chitosan–caseinate nanoparticles were synthesized by polyelectrolyte complex (PEC) formation. Caseinate is an anionic micellar nanocolloid in aqueous solutions, which association with the polycationic chitosan yielded polyelectrolyte complexes with caseinate cores surrounded by a chitosan corona. The pre-structuration of caseinate micelles facilitates the formation of natural polyelectrolyte nanoparticles with good stability and sizes around 200 nm. Such natural nanoparticles can be loaded with molecules for applications in drug-controlled release. In the nanoparticles processing, parameters such as the chitosan degree of acetylation (DA) and molecular weight, order of addition of the polyelectrolytes chitosan (polycation) and caseinate (polyanion), and added weight ratio of polycation:polyanion were varied, which were shown to influence the structure of the polyelectrolyte association, the nanoparticle size and zeta potential. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) analyses revealed the chemical structure of hydrogel colloidal systems consisting of nanoparticles that contain chitosan and caseinate. Transmission electron microscopy (TEM) allowed further characterization of the spherical morphology of the nanoparticles. Furtherly, insulin was chosen as a model drug to study the application of the nanoparticles as a safe biodegradable nanocarrier system for drug-controlled release. An insulin entrapment efficiency of 75% was achieved in the chitosan-caseinate nanoparticles.

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Sousa-Herves, Ana, Eduardo Fernandez-Megia, and Ricardo Riguera. "Synthesis and supramolecular assembly of clicked anionic dendritic polymers into polyion complex micelles." Chemical Communications, no. 27 (2008): 3136. http://dx.doi.org/10.1039/b805208e.

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Yang, Ke Wei, Xin Ru Li, Zhuo Li Yang, Ping Zhu Li, Fei Wang, and Yan Liu. "Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate:In vitroandin vivocharacterization." Journal of Biomedical Materials Research Part A 88A, no. 1 (January 2009): 140–48. http://dx.doi.org/10.1002/jbm.a.31866.

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50

Birault, Albane, Emilie Molina, Philippe Trens, Didier Cot, Guillaume Toquer, Nathalie Marcotte, Carole Carcel, John R. Bartlett, Corine Gérardin, and Michel Wong Chi Man. "Periodic Mesoporous Organosilicas from Polyion Complex Micelles - Effect of Organic Bridge on Nanostructure." European Journal of Inorganic Chemistry 2019, no. 27 (May 31, 2019): 3157–64. http://dx.doi.org/10.1002/ejic.201900487.

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