Academic literature on the topic 'Polyketides'

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Journal articles on the topic "Polyketides"

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Witzig, Reto M., and Christof Sparr. "Synthesis of Enantioenriched Tetra-ortho-3,3′-substituted Biaryls by Small-Molecule-Catalyzed Noncanonical Polyketide Cyclizations." Synlett 31, no. 01 (2019): 13–20. http://dx.doi.org/10.1055/s-0039-1690215.

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The arene-forming aldol condensation is a fundamental reaction in the biosynthesis of aromatic polyketides. Precisely controlled by the polyketide synthases, the highly reactive poly-β-carbonyl substrates are diverged into numerous aromatic natural products by selective cyclization reactions; a fascinating biosynthetic strategy that sparked our interest to investigate atroposelective aldol condensations. In this Account, we contextualize and highlight the ability of small-molecule catalysts to selectively convert noncanonical hexacarbonyl substrates in a double arene-forming aldol condensation
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Wang, Li, Hui Lu, and Yuanying Jiang. "Natural Polyketides Act as Promising Antifungal Agents." Biomolecules 13, no. 11 (2023): 1572. http://dx.doi.org/10.3390/biom13111572.

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Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is an urgent imperative to develop novel antifungal medications for clinical application. This comprehensive review provides a summary of the antifungal properties and mechanisms exhibited by natural polyketides, encompassing macrolide polyethers, polyether polyketides, xanthone polyketides, linear polyketides, hybrid polyketide non-ribosomal peptides
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Risdian, Chandra, Tjandrawati Mozef, and Joachim Wink. "Biosynthesis of Polyketides in Streptomyces." Microorganisms 7, no. 5 (2019): 124. http://dx.doi.org/10.3390/microorganisms7050124.

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Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks, and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of the polyketides producers. Some examples of polyketides produced by Streptomyces are ra
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Yang, Dongsoo, Hyunmin Eun, and Cindy Pricilia Surya Prabowo. "Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides." International Journal of Molecular Sciences 24, no. 10 (2023): 8923. http://dx.doi.org/10.3390/ijms24108923.

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Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antibiotics and anticancer agents. Most aromatic polyketides are produced from soil bacteria or plants, which are difficult to engineer and grow slowly in industrial settings. To this end, metabolic engineering and synthetic biology have been employed to efficiently engineer heterologous model microorgan
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Klopries, Stephan, Uschi Sundermann, and Frank Schulz. "Quantification ofN-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis." Beilstein Journal of Organic Chemistry 9 (April 5, 2013): 664–74. http://dx.doi.org/10.3762/bjoc.9.75.

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Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes. Individual malonic acid derivatives are typically required to be activated as coenzyme A-thioesters prior to their enzyme-catalyzed transfer onto the polyketide synthase. Control over the selection of malonic acid building blocks promises great potential for the experimental alteration of polyketide structure and bioactivity. One requirement for this endeavor is the supplem
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Rodríguez-Berríos, Raúl R., Agnes M. Ríos-Delgado, Amanda P. Perdomo-Lizardo, et al. "Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region." Antibiotics 12, no. 7 (2023): 1087. http://dx.doi.org/10.3390/antibiotics12071087.

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The Caribbean region is a hotspot of biodiversity (i.e., algae, sponges, corals, mollusks, microorganisms, cyanobacteria, and dinoflagellates) that produces secondary metabolites such as polyketides and polypropionates. Polyketides are a diverse class of natural products synthesized by organisms through a biosynthetic pathway catalyzed by polyketide synthase (PKS). This group of compounds is subdivided into fatty acids, aromatics, and polypropionates such as macrolides, and linear and cyclic polyethers. Researchers have studied the Caribbean region to find natural products and focused on isola
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Sayari, Mohammad, Aria Dolatabadian, Mohamed El-Shetehy, Pawanpuneet Kaur Rehal, and Fouad Daayf. "Genome-Based Analysis of Verticillium Polyketide Synthase Gene Clusters." Biology 11, no. 9 (2022): 1252. http://dx.doi.org/10.3390/biology11091252.

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Polyketides are structurally diverse and physiologically active secondary metabolites produced by many organisms, including fungi. The biosynthesis of polyketides from acyl-CoA thioesters is catalyzed by polyketide synthases, PKSs. Polyketides play roles including in cell protection against oxidative stress, non-constitutive (toxic) roles in cell membranes, and promoting the survival of the host organisms. The genus Verticillium comprises many species that affect a wide range of organisms including plants, insects, and other fungi. Many are known as causal agents of Verticillium wilt diseases
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Komaki, Hisayuki, and Tomohiko Tamura. "Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849T." Fermentation 9, no. 11 (2023): 924. http://dx.doi.org/10.3390/fermentation9110924.

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Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has the potential to produce diverse polyketides and nonribosomal peptides. Here, we sequenced the whole genome of S. cellostaticus NBRC 12849T and surveyed polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) gene clusters in the genome. The genome encoded 12 PKS, one NRPS and eight hybrid PKS/NRPS gene clusters. Among the 21 gene
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Pfeifer, Blaine A., and Chaitan Khosla. "Biosynthesis of Polyketides in Heterologous Hosts." Microbiology and Molecular Biology Reviews 65, no. 1 (2001): 106–18. http://dx.doi.org/10.1128/mmbr.65.1.106-118.2001.

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SUMMARY Polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases. A principal limitation for fundamental biochemical studies of these modular megasynthases, as well as for their applications in biotechnology, is the challenge associated with manipulating the natural microorganism that produces a polyketide of interest. To ameliorate this limitation, over the past decade several g
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Zhang, Wenjun, and Joyce Liu. "Recent Advances in Understanding and Engineering Polyketide Synthesis." F1000Research 5 (February 23, 2016): 208. http://dx.doi.org/10.12688/f1000research.7326.1.

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Polyketides are a diverse group of natural products that form the basis of many important drugs. The engineering of the polyketide synthase (PKS) enzymes responsible for the formation of these compounds has long been considered to have great potential for producing new bioactive molecules. Recent advances in this field have contributed to the understanding of this powerful and complex enzymatic machinery, particularly with regard to domain activity and engineering, unique building block formation and incorporation, and programming rules and limitations. New developments in tools for in vitro b
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Dissertations / Theses on the topic "Polyketides"

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Wang, Siyuan. "Engineering of polyketide biosynthetic pathways for bioactive molecules." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4684.

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Polyketides are a large group of structurally diverse natural products that have shown a variety of biological activities. These molecules are synthesized by polyketide synthases (PKSs). PKSs are classified into three types based on their sequence, primary structure, and catalytic mechanism. Because of the bioactivities of polyketide natural products, this study is focused on the engineering of PKS pathways for efficient production of useful bioactive molecules or structural modification to create new molecules for drug development. One goal of this research is to create an efficient method to
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Hager, Dominik. "From nucleosides to alkaloids and polyketides." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-153975.

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This dissertation describes the synthetic work on several natural products including nucleosides, alkaloids, and polyketides. The first and main part of this thesis focuses on the total synthesis of the nucleoside antibiotics herbicidin C and its hydrolysis product aureonuclemycin. Due to their diverse biological activity, the herbicidins are considered as promising herbicides for agricultural application. In cooperation with Bayer CropScience AG, a flexible and efficient access to the herbicidins was developed and the challenges and successes of this synthesis are described in detail. More s
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Zhang, Wenjun. "Engineered biosynthesis of bacterial aromatic polyketides." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1905657321&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Macpherson, Gordon R. "Biosynthesis of polyketides produced by marine microbes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ66668.pdf.

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Iqbal, Zafar. "Biosynthetic studies of strobilurin & mupirocin polyketides." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535223.

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Loughran, Mark Stephen. "The biosynthesis of erythromycin." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307943.

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Tam, Wan-ting, and 譚韻婷. "Characterization of polyketide synthases in penicillium marneffei." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/197137.

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Penicillium marneffei is a thermal dimorphic fungus that causes systemic mycosis in HIV-positive patients. The fungus displays unique phenotypic properties, including the yellow and black pigments on its conidia as well as the secretion of a diffusible red pigment during growth in mycelial phase. However, all these pigments have not been characterized. Investigation into the pigment production of the fungus can provide insights into the functions of the respective pigment to the fungus as well as their roles in fungal pathogenesis. This study reports the identification and characterization
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König, Ariane. "Genes for macrolide formation in rapamycin biosynthesis from Streptomyces hygroscopicus." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264158.

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Hill, Alison Margaret. "The biosynthesis of aspyrone." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319492.

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He, Weiguo. "Biochemical analysis of polyketide synthases domains and modules." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318326.

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Books on the topic "Polyketides"

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Rimando, Agnes M., and Scott R. Baerson, eds. Polyketides. American Chemical Society, 2007. http://dx.doi.org/10.1021/bk-2007-0955.

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J, Leeper F., and Vederas J. C, eds. Biosynthesis: Polyketides and vitamins. Springer, 1998.

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service), ScienceDirect (Online, ed. Complex enzymes in microbial natural product biosynthesis: Polyketides, aminocoumarins and carbohydrates. Academic, 2009.

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O'Hagan, David. The polyketide metabolites. E. Horwood, 1991.

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1957-, Rimando Agnes M., Baerson Scott R, and American Chemical Society. Division of Agricultural and Food Chemistry., eds. Polyketides: Biosynthesis, biological activity, and genetic engineering. American Chemical Society, 2007.

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Rohr, Jürgen, ed. Bioorganic Chemistry Deoxysugars, Polyketides and Related Classes: Synthesis, Biosynthesis, Enzymes. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/bfb0119233.

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service), ScienceDirect (Online, ed. Complex enzymes in microbial natural product biosynthesis: Overview articles and peptides. Elsevier, 2009.

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O'Hagan, David. The polyketide metabolites. Ellis Horwood, 1991.

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Evans, Bradley S., ed. Nonribosomal Peptide and Polyketide Biosynthesis. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3375-4.

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Ho, Stephen. Studies in Polyketide Total Synthesis. [publisher not identified], 2014.

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Book chapters on the topic "Polyketides"

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Schwarzbauer, Jan, and Branimir Jovančićević. "Polyketides." In From Biomolecules to Chemofossils. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-25075-5_4.

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Herbert, R. B. "Polyketides." In The Biosynthesis of Secondary Metabolites. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-010-9132-9_3.

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Seigler, David S. "Polyketides." In Plant Secondary Metabolism. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4913-0_5.

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Schaefers, Françoise, Tobias A. M. Gulder, Cyril Bressy, et al. "Polyketides." In From Biosynthesis to Total Synthesis. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781118754085.ch2.

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Ziani, Borhane Eddine Cherif, Abidi Mohamed, Chaima Ziani, and Liza Saher. "Polyketides." In Natural Secondary Metabolites. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18587-8_7.

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Contigli, Christiane, Marcelo Siqueira Valle, Sílvia Catarina Salgado Oloris, Lúcia Pinheiro Santos Pimenta, and Jacqueline Aparecida Takahashi. "Polyketides from Fungi." In Natural Secondary Metabolites. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18587-8_17.

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Simpson, Thomas J., and Russell J. Cox. "Polyketides in Fungi." In Natural Products in Chemical Biology. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118391815.ch6.

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Cox, Russell J., Elizabeth Skellam, and Katherine Williams. "Biosynthesis of Fungal Polyketides." In Physiology and Genetics. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71740-1_13.

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Schuemann, Julia, and Christian Hertweck. "Biosynthesis of Fungal Polyketides." In Physiology and Genetics. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00286-1_16.

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Shen, Ben. "Biosynthesis of Aromatic Polyketides." In Biosynthesis. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-48146-x_1.

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Conference papers on the topic "Polyketides"

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Lee, TH, SW Wang, YL Chen, and TY Shih. "Bioactive polyketides from a marine green alga-derived fungus Aspergillus sp. NTU967." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399858.

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Poteshkina, K. I., and A. M. Stenkova. "DEVELOPMENT OF A TEST SYSTEM FOR SCREENING BACTERIA PRODUCING BIOLOGICALLY ACTIVE NONRIBOSOMAL PEPTIDES AND POLYKETIDES." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-360.

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An important direction in science and medicine is the study of biologically active compounds produced by marine microorganisms, due to which there is a search for new promising drugs. This study is aimed at screening a collection of marine microorganisms obtained from invertebrates from the Vostok Bay of Primorsky Krai for the presence of biochemical gene clusters of nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS).
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Chang, FR, DY Yang, YB Cheng, and YC Wu. "Polyketides and Anti-inflammatory Activities of the Endophytic Fungus Aspergillus ochraceopetaliformis Isolated from Anthurium brownii." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608096.

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TOWNSEND, CRAIG A. "DECONSTRUCTION OF ITERATIVE POLYKETIDE SYNTHASES." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0042.

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Nassar, S., B. Liu, and L. Beerhues. "Polyketide-related biosynthesis of plant anthranoids." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399796.

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Bunzel, C., B. Liu, and L. Beerhues. "Novel dual-function type III polyketide synthase from Hypericum polyphyllum." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399659.

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Erokhin, D. V., O. D. Mikityuk, L. A. Shcherbakova, and V. G. Dzhavakhiya. "Inhibition of the biosynthesis of polyketide mycotoxins by microbial metabolites." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.065.

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6-Demethylmevinoliin, a secondary metabolite of Penicillum citrinum, is able to efficiently inhibit the biosynthesis of two polypeptide mycotoxins, aflatoxin B1 and zearalenone, by 92 and 78% of the control, respectively.
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Deaghileva, Angela. "Identification of mycotoxin-producing species of fusarium in tomato ontogenesis." In VIIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2024. https://doi.org/10.53040/gppb8.2024.12.

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The results of molecular identification of toxigenic Fusarium spp. in local tomato varieties at some vegetative phases are presented. F. oxysporum, F. verticillioides, F. proliferatum, F. avenaceum, F. equiseti, F. solani were found at different stages of tomato development. Sequences of FUM gene cluster involved in the synthesis of Fumonisin B1 and Polyketide synthase (PKS13) gene sequences involved in the synthesis of Zearalenone were revealed in some tomato varieties infected by certain toxigenic Fusarium species.
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Prediger, Patrícia, and Luiz Carlos Dias. "Synthesis of Polyketide Fragments in Order to Study the Elaiophylin Biosynthesis." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201391515128.

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Hiebl, V., D. Wang, EH Heiss, R. Mueller, AG Atanasov, and VM Dirsch. "The polyketide soraphen A exerts beneficial effects on cholesterol homeostasis in macrophages." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400099.

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Reports on the topic "Polyketides"

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Cytryn, E., Sean F. Brady, and O. Frenkel. Cutting edge culture independent pipeline for detection of novel anti-fungal plant protection compounds in suppressive soils. United States-Israel Binational Agricultural Research and Development Fund, 2022. http://dx.doi.org/10.32747/2022.8134142.bard.

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Fusarium oxysporum spp. causes Panama disease in bananas and crown and root rot in an array of vegetables and field crops, but increased regulations have restricted the use of many conventional chemical pesticides, and there are a limited number of commercially available products effective against them. The soil microbiome represents a largely untapped reservoir of secondary metabolites that can potentially antagonize fungal pathogens. However, most soil bacteria cannot be cultivated using conventional techniques and therefore most of these compounds remain unexplored. The overall goal of this
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Marimo, Patience. Steps Towards Deciphering the Post-Polyketide Synthase Tailoring Steps in the Phoslactomycin Biosynthesis Pathway. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.2405.

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Magnuson, Jon. Accelerating Polyketide Synthase Engineering for High TRY Production of Biofuels and Bioproducts - CRADA 474. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1827793.

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Backman, Tyler. Accelerating polyketide synthase engineering for high TRY production of biofuels and bioproducts: CRADA Final Report. Office of Scientific and Technical Information (OSTI), 2024. http://dx.doi.org/10.2172/2324813.

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Keasling, Jay, Tyler Backman, Robert Haushalter, et al. Final Technical Report Project Title: Accelerating polyketide synthase engineering for high TRY production of biofuels and bioproducts. Office of Scientific and Technical Information (OSTI), 2024. http://dx.doi.org/10.2172/2279068.

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Prusky, Dov, Nancy P. Keller, and Amir Sherman. global regulation of mycotoxin accumulation during pathogenicity of Penicillium expansum in postharvest fruits. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7600012.bard.

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Background to the topic- Penicilliumas a postharvest pathogen and producer of the mycotoxin PAT. Penicilliumspp. are destructive phytopathogens, capable of causing decay in many deciduous fruits, during postharvest handling and storage; and the resulting losses can amount to 10% of the stored produce and the accumulation of large amounts of the mycotoxinpatulin. The overall goal of this proposal is to identify critical host and pathogen factors that modulate P. expansummycotoxin genes and pathways which are required for PAT production and virulence. Our preliminary results indicated that gluco
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