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Dissertations / Theses on the topic 'Polyketides'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wang, Siyuan. "Engineering of polyketide biosynthetic pathways for bioactive molecules." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4684.

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Polyketides are a large group of structurally diverse natural products that have shown a variety of biological activities. These molecules are synthesized by polyketide synthases (PKSs). PKSs are classified into three types based on their sequence, primary structure, and catalytic mechanism. Because of the bioactivities of polyketide natural products, this study is focused on the engineering of PKS pathways for efficient production of useful bioactive molecules or structural modification to create new molecules for drug development. One goal of this research is to create an efficient method to

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2

Hager, Dominik. "From nucleosides to alkaloids and polyketides." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-153975.

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This dissertation describes the synthetic work on several natural products including nucleosides, alkaloids, and polyketides. The first and main part of this thesis focuses on the total synthesis of the nucleoside antibiotics herbicidin C and its hydrolysis product aureonuclemycin. Due to their diverse biological activity, the herbicidins are considered as promising herbicides for agricultural application. In cooperation with Bayer CropScience AG, a flexible and efficient access to the herbicidins was developed and the challenges and successes of this synthesis are described in detail. More s

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3

Zhang, Wenjun. "Engineered biosynthesis of bacterial aromatic polyketides." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1905657321&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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4

Macpherson, Gordon R. "Biosynthesis of polyketides produced by marine microbes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ66668.pdf.

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5

Iqbal, Zafar. "Biosynthetic studies of strobilurin & mupirocin polyketides." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535223.

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6

Loughran, Mark Stephen. "The biosynthesis of erythromycin." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307943.

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7

Tam, Wan-ting, and 譚韻婷. "Characterization of polyketide synthases in penicillium marneffei." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/197137.

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Penicillium marneffei is a thermal dimorphic fungus that causes systemic mycosis in HIV-positive patients. The fungus displays unique phenotypic properties, including the yellow and black pigments on its conidia as well as the secretion of a diffusible red pigment during growth in mycelial phase. However, all these pigments have not been characterized. Investigation into the pigment production of the fungus can provide insights into the functions of the respective pigment to the fungus as well as their roles in fungal pathogenesis. This study reports the identification and characterization

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8

KoÌˆnig, Ariane. "Genes for macrolide formation in rapamycin biosynthesis from Streptomyces hygroscopicus." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264158.

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9

Hill, Alison Margaret. "The biosynthesis of aspyrone." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319492.

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10

He, Weiguo. "Biochemical analysis of polyketide synthases domains and modules." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318326.

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11

Findlay, A. D. "Total synthesis and structural assignment of antimitotic polyketides." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599022.

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The first part of this dissertation describes the revised stereochemical assignment of the cytotoxic marine macrolide dolastain 19, isolated from the sea hare <i>Dolabella auricularia, </i>which was proposed and subsequently validated by completion of the first total synthesis. Based upon molecular modelling and common biogenetic considerations, four of the twelve stereocentres of the originally proposed structure 50 were inverted in configuration. The carbon backbone 56 of this stereochemically reassigned 14-membered macrolide 54 was assembled using an asymmetric vinylogous Mukaiyama aldol re

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12

Lou, Samuel. "Stereochemical Control of Polyketides through Asymmetric Aldol Reaction." Master's thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/37095.

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Polyketides are a group of complex natural products that can inhibit the growth of bacteria, viruses, fungi, and tumor cells. Most polyketides are very difficult to extract from bacteria. Therefore, numerous syntheses of polyketide-related synthons have been attempted. <p> However, controlling the stereochemistry of the polyketide poses the most challenging task for researchers. The aim of this report is to discuss control of the stereochemistry of the polyketide-related synthons in asymmetric aldol reactions. Several important methodologies for stereochemical control in the aldol reac

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13

Ackrill, Thomas. "Synthetic and biosynthetic studies on polyketides and diarylheptanoids." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682231.

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This thesis describes the synthesis of putative intermediates to investigate the biosynthesis of the polyketide bacillaene and the development of a novel cyclisation reaction and its application towards the total synthesis of calyxin I. Chapter one describes the design and synthesis of a variety of analogues required for the investigation of the biosynthesis of bacillaene, a natural product isolated from extracts of Bacillus subtilis Chapter two describes the development of a new cyclisation reaction using y,δ-unsaturated alcohols with a pendant phenol and an electrophile. After much investiga

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14

Jacobs, Adam. "Aspyrone biosynthesis." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241064.

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15

Bhatia, Mohamed. "Synthetic studies towards the solanapyrones." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365966.

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16

Schicker, Susanna Heidi. "Synthesis of intermediates for chalcone and 6-MSA biosynthesis." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336910.

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17

Less, Simon. "Biosynthetic studies on tetronasin." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364530.

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18

Marimo, Patience. "Steps Towards Deciphering the Post-Polyketide Synthase Tailoring Steps in the Phoslactomycin Biosynthesis Pathway." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2408.

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Phoslactomycins (PLMs) are a group of natural products belonging to a polyketides class. These polyketides are synthesized by sequential reaction catalyzed by a collection of enzymes activities called polyketide synthases. A polyketide is a large class of diverse compounds that are characterized by more than two carbonyl groups connected by single intervening carbon atoms. In other words, a polyketide is a polymer whose monomer is a ketide. The PLMs are also known as phosphazomycins or phospholines. These compounds were isolated based on antifungal and antitumor activities. This array of promi

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19

Oldfield, Mark F. "Biosynthesis of fungal polyketides : compactin and 6-methylsalicylic acid." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261336.

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20

McGaw, Oliver. "Studies towards the novel synthesis of benzoisochromane quinone polyketides." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/58538/.

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Granaticin is a structurally unique member of the benzoisochromane quinone (BIQ) family of antibiotics. The molecule and its derivative exhibit a sugar moiety fusted to the naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic attachment of this substituent is currently unknown. This project aimed to devise a novel and elegant synthesis towards the granaticin aglycone and other benzoisochromane quinone natural compounds with the long term aim of discerning the mechanism of glycosylation. This thesis shows a

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21

Yin, Sen [Verfasser]. "Biosynthesis of fungal alkyl citrates and polyketides / Sen Yin." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2020. http://d-nb.info/1220422126/34.

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22

Stössel, Daniel. "Chemistry of 1,3,5-tris (trimethylsiloxy) -1-methoxyhexa-1,3,5-triene." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75352.

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The title compound was synthesized and its chemistry studied for the first time. It reacts with carbon electrophiles initially at its $ epsilon$-position. The condensation with aliphatic imidazolides or similar acylating agents furnished methyl 6-alkyl-2,4-dihydroxy benzoates in a 5C + 1C fashion. Reaction with aromatic imidazolides, also in a 5C + 1C manner, gave unsymmetrical biphenyls with the 2-carbomethoxy-3,5-dihydroxyphenyl moiety. A regiocontrolled synthesis of naphthalene derivatives was developed by reaction with the appropriate 1,3,5-tris-electrophiles in a 5C + 5C fashion.

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23

Bhogal, Pamela. "The incorporation of substrate analogues and proposed intermediates into tetraketide products by 6-methylsalicylic acid synthase." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307098.

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24

Donlevy, Philip James. "The biosynthesis of pseudomonic acid." Thesis, University of Bristol, 1996. http://hdl.handle.net/1983/981be1e9-5a9a-4c42-ab3f-055a64319aad.

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25

Razzak, Mina. "Synthetic studies of bioactive polyketides : the saliniketals, pelorusides and bafilomycins." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/252198.

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26

Zormpaides, Vassilios. "The utilisation of oils in Saccharopolyspora erythraea cultures producing polyketides." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367757.

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27

Le, Sann Christine. "Enantioselective synthesis of N-Acetylcysteamine thioester putative intermediates to polyketides." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340274.

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28

Bayazeed, Abrar Ahmad Ali. "Studies towards the total synthesis of DEM30355/A and related polyketides." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3746.

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DEM30355/A 1 is a novel bioactive natural product polyketide isolated from an Amycolatopsis bacteria. 1 shows antibacterial activity against several pathogenic Gram positive bacteria, including methicillin-resistant Staphylococcus aureus. Thus we have explored the total synthesis of 1 and a number of related polyketide natural products (Figure 1). Figure 1: Structure of DEM30355A 1. In our first attempts towards the synthesis of target molecule 1 we examined several synthetic routes towards a key intermediate 2. These routes included: (a) the synthesis of Wittig product 3, followed by an unsuc

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29

Chen, Hao Harrison Paul H. M. "A biomimetic decarboxylative condensation on a glycoluril scaffold and biosynthesis of streptolydigin." *McMaster only, 2004.

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30

Westaway, Susan Marie. "Squalestatin biosynthesis : synthesis and incorporation of assembly intermediates." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296602.

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31

Crump, Matthew Philip. "NMR studies on type II polyketide acyl carrier proteins." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294958.

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32

Goode, Ann Marie Liles Mark Russell. "Polyketide synthase pathway discovery from soil metagenomic libraries." Auburn, Ala., 2009. http://hdl.handle.net/10415/1805.

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33

Yan, John Kam. "Functional Separation of Multimodular Type I PKS Polypeptides by Utilizing Matched Docking Domains From a Heterologous PKS System." PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/135.

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Bacterial type I modular polyketide synthases (PKS) are large multifunctional enzyme systems responsible for the biosynthesis of complex polyketide natural products such as erythromycin, pikromycin, and borrelidin. Type I systems are comprised of a loading module which generally selects an appropriate acyl group starter unit, and multiple discrete extension modules, responsible for each single round of acyl group incorporation into the final polyketide core structure. These modules can exist naturally as either single discrete polypeptides, such as modules 5 and 6 from the pikromycin PKS (PikA

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34

Stevens, David Cole. "Developing Heterologous Expression Platforms for the Production of Polyketides from Microbial Hosts." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20220.

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Bacterial polyketides possess an enormous range of chemical diversity and biological function. Many polyketides such as tetracycline, epothilone, and rapamycin have been developed into key clinical pharmaceuticals in a broad range of therapeutic areas. Sequencing of bacterial genomes has shown that there are many more polyketide biosynthetic pathways than there are polyketides isolated from standard cultivation techniques. These genetically encoded polyketide natural products from cultivatable and uncultivatable bacteria represent one of the greatest remaining untapped reservoirs of new natur

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35

Shang, Shiying. "A unified synthetic approach to polyketides having both skeletal and stereochemical diversity /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528359411&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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36

Harris, Jonathan Peter. "The biosynthesis of ochratoxin A and other structurally related polyketides by Aspergillus ochraceus." Thesis, Imperial College London, 1996. http://hdl.handle.net/10044/1/7972.

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37

Koopmans, Kyra Romy Mariette Verfasser], Frank [Gutachter] Schuz, and Robert [Gutachter] [Kourist. "Extension of nascent polyketides / Kyra Romy Mariette Koopmans. Gutachter: Frank Schuz ; Robert Kourist." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/111232674X/34.

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38

Koopmans, Kyra Romy Mariette [Verfasser], Frank Gutachter] Schuz, and Robert [Gutachter] [Kourist. "Extension of nascent polyketides / Kyra Romy Mariette Koopmans. Gutachter: Frank Schuz ; Robert Kourist." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/111232674X/34.

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39

Chang, Shuh-Kuen. "Studies toward the total synthesis of amphidinol 3." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150261354.

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40

Hariprakasha, H. K. "Synthesis Of Natural Products Based On Cyclohexadienes." Thesis, Indian Institute of Science, 1996. https://etd.iisc.ac.in/handle/2005/118.

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The thesis entitled "Synthesis of Natural Products Based on Cyclohexadienes" consists of two chapters. Chapter 1 is divided into two parts. Part I gives a brief introduction to the structure, synthesis, biosynthesis and biological activities of some naturally occurring phthalides (eg. mycophenolic acid 1, zinniol2, phthalides 3 & 4). A general strategy for the preparation of highly substituted phthalides is also described. Cycloaddition of 1,s-dimethoxycoclohexa-1, 4-diene with dimethylacetylenedicarboxylate(DMAD) followed by an Alder-Rickert reaction gave the diester 5 which upon hydrolysis

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41

Hariprakasha, H. K. "Synthesis Of Natural Products Based On Cyclohexadienes." Thesis, Indian Institute of Science, 1996. http://hdl.handle.net/2005/118.

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The thesis entitled "Synthesis of Natural Products Based on Cyclohexadienes" consists of two chapters. Chapter 1 is divided into two parts. Part I gives a brief introduction to the structure, synthesis, biosynthesis and biological activities of some naturally occurring phthalides (eg. mycophenolic acid 1, zinniol2, phthalides 3 & 4). A general strategy for the preparation of highly substituted phthalides is also described. Cycloaddition of 1,s-dimethoxycoclohexa-1, 4-diene with dimethylacetylenedicarboxylate(DMAD) followed by an Alder-Rickert reaction gave the diester 5 which upon hydrolysis w

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42

Eichenberger, Michael [Verfasser], Beatrix [Akademischer Betreuer] Süß, Heribert [Akademischer Betreuer] Warzecha, and Michael [Akademischer Betreuer] Næsby. "Biosynthesis of plant polyketides in yeast / Michael Eichenberger ; Beatrix Süß, Heribert Warzecha, Michael Næsby." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2019. http://d-nb.info/1182537529/34.

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43

Cadou, Romain F. "Studies in cyclic ether synthesis : Part one: Domino cyclisations to cyclic ethers -- Part two: Synthetic studies towards neopeltolide." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/1025.

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Tetrahydrofuran (THF) and tetrahydropyran (THP) rings are commonly found in a wide range of natural products and biologically active compounds. In total synthesis, the formation of THF/THP motifs is often the key step but existing methods often involve numerous steps and low overall efficiencies. Part one of this thesis details the development of a practical method for the synthesis of THF rings by the controlled mono-addition/cyclisation of organolithium species to C2-symmetric diepoxides (Scheme A-1). This method can also be applied to the synthesis of bis-THF rings from triepoxides and has

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44

Vanga, Raghava Reddy. "Studies toward the synthesis and structural elucidation of chamuvarinin." Thesis, University of St Andrews, 2009. http://hdl.handle.net/10023/953.

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Chamuvarinin (22) is a unique annoanceaeous acetogenin isolated from the roots of Senegalese medicinal plant Uvaria chamae by Laurens and co-workers in 2004. It displays highly potent cytotoxicity towards the cervical cancer cell lines (KB 3-1, IC₅₀= 0.8 nM). Structurally, chamuvarinin is the first reported acetogenin to contain an adjacently linked bis-THF-THP ring system spanning the C15-C28 carbon backbone. However, initial efforts to assign the relative and absolute configuration within this stereochemical array, on the basis of ¹H and ¹³C NMR analysis, provided only partial information pe

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45

Ellerbrock, Pascal [Verfasser], and Dirk [Akademischer Betreuer] Trauner. "Biomimetic synthesis of polyketides : dibefurin and epicolactone and synthetic studies toward gracilin terpenoids / Pascal Ellerbrock. Betreuer: Dirk Trauner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1090785569/34.

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46

Ali, Ahmed Faisal Ahmed Ismail [Verfasser], Frank [Akademischer Betreuer] Schulz, and Alfred [Akademischer Betreuer] Wittinghofer. "Fermentation and biological profiling of non-natural polyketides / Ahmed Faisal Ahmed Ismail Ali. Gutachter: Frank Schulz ; Alfred Wittinghofer." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1095884786/34.

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47

Cummings, Matthew. "Harnessing synthetic biology for the bioprospecting and engineering of aromatic polyketide synthases." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/harnessing-synthetic-biology-for-the-bioprospecting-and-engineering-of-aromatic-polyketide-synthases(e2317dbb-c1b7-4e6e-83d5-03a1453848b2).html.

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Antimicrobial resistant microorganisms are predicted to pose an existential threat to humanity inside of the next 3 decades. Characterisation of novel acting antimicrobial small molecules from microorganisms has historically counteracted this evolutionary arms race, however the bountiful source of pharmaceutically relevant bioactive specialised metabolites discovered in the Golden era of drug discovery has long since dried up. The clinicians' arsenal of useful antimicrobials is diminishing, and a fresh perspective on specialised metabolite discovery is necessary. This call to action is being a

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48

Prince, Emily Katherine. "Chemically-mediated interactions in the plankton:." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22701.

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Thesis (Ph. D.)--Biology, Georgia Institute of Technology, 2008.<br>Committee Chair: Kubanek, Julia; Committee Member: Hay, Mark; Committee Member: Jiang, Lin; Committee Member: Pavia, Henrik; Committee Member: Snell, Terry.

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Hager, Dominik [Verfasser]. "From Nucleosides to Alkaloids and Polyketides: Total Synthesis of Herbicidin C and Studies Toward Stephadiamine and Divergolides / Dominik Hager." München : Verlag Dr. Hut, 2013. http://d-nb.info/1031843728/34.

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50

Nybo, Stephen Eric. "ISOLATION AND ELUCIDATION OF THE CHRYSOMYCIN BIOSYNTHETIC GENE CLUSTER AND ALTERING THE GLYCOSYLATION PATTERNS OF TETRACENOMYCINS AND MITHRAMYCIN-PATHWAY MOLECULES." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/812.

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Natural products occupy a central role as the majority of currently used antibiotic and anticancer agents. Among these are type-II polyketide synthase (PKS)-derived molecules, or polyketides, which are produced by many representatives of the genus Streptomyces. Some type-II polyketides, such as the tetracyclines and the anthracycline doxorubicin, are currently employed as therapeutics. However, several polyketide molecules exhibit promising biological activity, but due to toxic side effects or solubility concerns, remain undeveloped as drugs. Gilvocarcin V (GV) (topoisomerase II inhibitor) has

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